CN107531687A - 能够实现软骨复壮的小分子 - Google Patents

能够实现软骨复壮的小分子 Download PDF

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Publication number
CN107531687A
CN107531687A CN201680024174.9A CN201680024174A CN107531687A CN 107531687 A CN107531687 A CN 107531687A CN 201680024174 A CN201680024174 A CN 201680024174A CN 107531687 A CN107531687 A CN 107531687A
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CN
China
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nhnr
alkyl
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Pending
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CN201680024174.9A
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English (en)
Chinese (zh)
Inventor
D·叶夫谢耶恩柯
B·J·万汉德尔
V·约翰
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University of California San Diego UCSD
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University of California San Diego UCSD
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Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CN107531687A publication Critical patent/CN107531687A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201680024174.9A 2015-02-27 2016-02-29 能够实现软骨复壮的小分子 Pending CN107531687A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562126010P 2015-02-27 2015-02-27
US62/126,010 2015-02-27
PCT/US2016/020126 WO2016138533A2 (en) 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation

Publications (1)

Publication Number Publication Date
CN107531687A true CN107531687A (zh) 2018-01-02

Family

ID=56789264

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680024174.9A Pending CN107531687A (zh) 2015-02-27 2016-02-29 能够实现软骨复壮的小分子

Country Status (8)

Country Link
US (2) US11072592B2 (https=)
EP (1) EP3262040A4 (https=)
JP (1) JP2018508513A (https=)
KR (1) KR20170122788A (https=)
CN (1) CN107531687A (https=)
AU (1) AU2016224975B2 (https=)
CA (1) CA2977401A1 (https=)
WO (1) WO2016138533A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112877283A (zh) * 2021-02-10 2021-06-01 安徽农业大学 一种鸡原代软骨细胞分离培养及鉴定的方法
CN114276999A (zh) * 2022-03-03 2022-04-05 中日友好医院(中日友好临床医学研究所) 黑素瘤细胞株及其制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016138533A2 (en) 2015-02-27 2016-09-01 The Regents Of The University Of California Small molecules that enable cartilage rejuvanation
EP3493803A4 (en) * 2016-08-05 2020-04-22 The Regents of The University of California GP130 MODULATORS
KR20190058494A (ko) * 2016-08-26 2019-05-29 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 모낭 줄기 세포 활성화 및 모발 성장
EP3758700B1 (en) 2018-02-28 2024-07-31 University of Southern California Compositions for modulating inflammatory and degenerative disorders
EP4511378A4 (en) * 2022-04-20 2026-03-11 Carthronix Inc GP130 Small Molecule Modulators for Signaling Channels

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WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
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CN100496493C (zh) * 2001-08-13 2009-06-10 詹森药业有限公司 2-氨基-4,5-三取代噻唑基衍生物
CN101801964A (zh) * 2007-05-22 2010-08-11 艾其林医药公司 杂芳基取代的噻唑及其作为抗病毒剂的用途
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CN102584813A (zh) * 2003-05-14 2012-07-18 Ngc药物公司 化合物及其在调节淀粉样蛋白β中的用途
US20120283268A1 (en) * 2006-04-07 2012-11-08 Anthony Giordano Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers
CN103130792A (zh) * 2011-11-30 2013-06-05 江苏正大天晴药业股份有限公司 一种2-氨基噻唑类化合物
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CN100496493C (zh) * 2001-08-13 2009-06-10 詹森药业有限公司 2-氨基-4,5-三取代噻唑基衍生物
CN102584813A (zh) * 2003-05-14 2012-07-18 Ngc药物公司 化合物及其在调节淀粉样蛋白β中的用途
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
CN101247807A (zh) * 2005-05-09 2008-08-20 艾其林医药公司 噻唑化合物及使用方法
WO2006135604A2 (en) * 2005-06-09 2006-12-21 Merck & Co., Inc. Inhibitors of checkpoint kinases
CN101263130A (zh) * 2005-09-13 2008-09-10 詹森药业有限公司 2-苯胺-4-芳基取代的噻唑衍生物
US20120283268A1 (en) * 2006-04-07 2012-11-08 Anthony Giordano Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers
CN101801964A (zh) * 2007-05-22 2010-08-11 艾其林医药公司 杂芳基取代的噻唑及其作为抗病毒剂的用途
US20110112073A1 (en) * 2008-05-15 2011-05-12 Duke University Compositions and methods relating to heat shock transcription factor activating compounds and targets thereof
CN103130792A (zh) * 2011-11-30 2013-06-05 江苏正大天晴药业股份有限公司 一种2-氨基噻唑类化合物
WO2015021191A1 (en) * 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators

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PARAMESHWAR MAKAM，等: "2-Aminothiazole derivatives as antimycobacterial agents: Synthesis, characterization, in vitro and in silico studies", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112877283A (zh) * 2021-02-10 2021-06-01 安徽农业大学 一种鸡原代软骨细胞分离培养及鉴定的方法
CN114276999A (zh) * 2022-03-03 2022-04-05 中日友好医院(中日友好临床医学研究所) 黑素瘤细胞株及其制备方法

Also Published As

Publication number Publication date
AU2016224975A1 (en) 2017-09-07
JP2018508513A (ja) 2018-03-29
EP3262040A4 (en) 2018-09-12
US20180244638A1 (en) 2018-08-30
US20190169141A1 (en) 2019-06-06
EP3262040A2 (en) 2018-01-03
AU2016224975B2 (en) 2020-10-22
CA2977401A1 (en) 2016-09-01
WO2016138533A2 (en) 2016-09-01
US11072592B2 (en) 2021-07-27
US11247974B2 (en) 2022-02-15
WO2016138533A3 (en) 2016-12-01
KR20170122788A (ko) 2017-11-06

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