CN107513069A - 手性吡咯并嘧啶化合物的制备方法 - Google Patents
手性吡咯并嘧啶化合物的制备方法 Download PDFInfo
- Publication number
- CN107513069A CN107513069A CN201610432126.5A CN201610432126A CN107513069A CN 107513069 A CN107513069 A CN 107513069A CN 201610432126 A CN201610432126 A CN 201610432126A CN 107513069 A CN107513069 A CN 107513069A
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- methyl
- reaction
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*(C)C(c1c(C)c(N)c(C)c(N)c1C(N(C)C)=O)=O Chemical compound C*(C)C(c1c(C)c(N)c(C)c(N)c1C(N(C)C)=O)=O 0.000 description 12
- GQYIAGSPAJELFY-UHFFFAOYSA-N O=C(C1)NNC11CCCCCC1 Chemical compound O=C(C1)NNC11CCCCCC1 GQYIAGSPAJELFY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610432126.5A CN107513069A (zh) | 2016-06-16 | 2016-06-16 | 手性吡咯并嘧啶化合物的制备方法 |
| US16/309,882 US10766901B2 (en) | 2016-06-16 | 2017-06-15 | Preparation method for chiral pyrrolopyrimidine compound |
| JP2018565715A JP6998896B2 (ja) | 2016-06-16 | 2017-06-15 | キラルピロロピリミジン化合物の製造方法 |
| PCT/CN2017/088421 WO2017215627A1 (zh) | 2016-06-16 | 2017-06-15 | 手性吡咯并嘧啶化合物的制备方法 |
| CN201780037151.6A CN109311892B (zh) | 2016-06-16 | 2017-06-15 | 手性吡咯并嘧啶化合物的制备方法 |
| EP17812738.7A EP3473625B1 (en) | 2016-06-16 | 2017-06-15 | Preparation method for chiral pyrrolopyrimidine compound |
| ES17812738T ES2877678T3 (es) | 2016-06-16 | 2017-06-15 | Método de preparación para un compuesto de pirrolopirimidina quiral |
| CN202010744086.4A CN111875607B (zh) | 2016-06-16 | 2017-06-15 | 手性吡咯并嘧啶化合物的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610432126.5A CN107513069A (zh) | 2016-06-16 | 2016-06-16 | 手性吡咯并嘧啶化合物的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107513069A true CN107513069A (zh) | 2017-12-26 |
Family
ID=60663390
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610432126.5A Pending CN107513069A (zh) | 2016-06-16 | 2016-06-16 | 手性吡咯并嘧啶化合物的制备方法 |
| CN202010744086.4A Active CN111875607B (zh) | 2016-06-16 | 2017-06-15 | 手性吡咯并嘧啶化合物的制备方法 |
| CN201780037151.6A Active CN109311892B (zh) | 2016-06-16 | 2017-06-15 | 手性吡咯并嘧啶化合物的制备方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010744086.4A Active CN111875607B (zh) | 2016-06-16 | 2017-06-15 | 手性吡咯并嘧啶化合物的制备方法 |
| CN201780037151.6A Active CN109311892B (zh) | 2016-06-16 | 2017-06-15 | 手性吡咯并嘧啶化合物的制备方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10766901B2 (enExample) |
| EP (1) | EP3473625B1 (enExample) |
| JP (1) | JP6998896B2 (enExample) |
| CN (3) | CN107513069A (enExample) |
| ES (1) | ES2877678T3 (enExample) |
| WO (1) | WO2017215627A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024193496A1 (zh) * | 2023-03-17 | 2024-09-26 | 北京普祺医药科技股份有限公司 | 吡咯并嘧啶化合物或其可药用盐的制备方法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019413421B9 (en) * | 2018-12-24 | 2025-02-20 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Treatment use of pyrrolopyrimidine compound, and solid pharmaceutical composition of pyrrolopyrimidine compound |
| EP4119562A4 (en) * | 2020-03-09 | 2024-04-24 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | USE OF A PYRROLOPYRIMIDINE COMPOUND FOR THE TREATMENT OF HEMOPHAGOCYTIC SYNDROME |
| WO2022040180A1 (en) | 2020-08-18 | 2022-02-24 | Incyte Corporation | Process and intermediates for preparing a jak inhibitor |
| US11897889B2 (en) | 2020-08-18 | 2024-02-13 | Incyte Corporation | Process and intermediates for preparing a JAK1 inhibitor |
| CN114085224A (zh) * | 2020-08-25 | 2022-02-25 | 北京普祺医药科技有限公司 | 一种吡咯并嘧啶化合物的制备方法 |
| EP4361152A4 (en) | 2021-06-21 | 2025-05-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Use of a pyrrholopyrimidine compound and pharmaceutical composition thereof for the treatment of chronic graft-versus-host disease |
| US12071439B2 (en) | 2021-07-12 | 2024-08-27 | Incyte Corporation | Process and intermediates for preparing a JAK inhibitor |
| CN120459106A (zh) | 2022-03-21 | 2025-08-12 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物治疗中高危骨髓纤维化的用途 |
| WO2024027790A1 (zh) | 2022-08-04 | 2024-02-08 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物治疗急性移植物抗宿主病的用途 |
| WO2024042448A1 (en) * | 2022-08-22 | 2024-02-29 | Granules India Limited | An improved process for the preparation of ruxolitinib |
| WO2024230727A1 (zh) * | 2023-05-09 | 2024-11-14 | 正大天晴药业集团股份有限公司 | 一种吡咯并[2,3-c]吡啶酮化合物的联用药物组合物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5616499A (en) * | 1979-07-19 | 1981-02-17 | Yamasa Shoyu Co Ltd | 6-c-purine nucleoside derivative and its preparation |
| JPS5841897A (ja) * | 1981-09-04 | 1983-03-11 | Yamasa Shoyu Co Ltd | ６−（４−ピラゾリル）プリンリボヌクレオシド誘導体およびその製造法 |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| US20050008640A1 (en) * | 2003-04-23 | 2005-01-13 | Wendy Waegell | Method of treating transplant rejection |
| TWI630207B (zh) | 2005-12-13 | 2018-07-21 | 英塞特控股公司 | 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶 |
| TWI665200B (zh) * | 2009-01-15 | 2019-07-11 | 英塞特公司 | 製造ｊａｋ抑制劑之方法及相關中間化合物 |
| AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
| CN103848810A (zh) | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| CN103739607A (zh) * | 2014-01-22 | 2014-04-23 | 无锡方圆环球显示技术股份有限公司 | 一种基于三并咔唑多臂结构红光材料及其制备方法与应用 |
| EP3152214B1 (en) * | 2014-06-04 | 2020-01-29 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
| CN105218548A (zh) | 2014-06-09 | 2016-01-06 | 上海海和药物研究开发有限公司 | 一种新型杂环化合物及其制备方法和作为激酶抑制剂的用途 |
| CN105315286B (zh) * | 2014-07-30 | 2018-08-17 | 连云港润众制药有限公司 | 西格列汀的制备 |
| CN105777754B (zh) * | 2014-12-16 | 2019-07-26 | 北京赛林泰医药技术有限公司 | 吡咯并嘧啶化合物 |
| CN107759600A (zh) | 2016-06-16 | 2018-03-06 | 正大天晴药业集团股份有限公司 | 作为jak抑制剂的吡咯并嘧啶化合物的结晶 |
-
2016
- 2016-06-16 CN CN201610432126.5A patent/CN107513069A/zh active Pending
-
2017
- 2017-06-15 CN CN202010744086.4A patent/CN111875607B/zh active Active
- 2017-06-15 JP JP2018565715A patent/JP6998896B2/ja active Active
- 2017-06-15 WO PCT/CN2017/088421 patent/WO2017215627A1/zh not_active Ceased
- 2017-06-15 ES ES17812738T patent/ES2877678T3/es active Active
- 2017-06-15 US US16/309,882 patent/US10766901B2/en active Active
- 2017-06-15 CN CN201780037151.6A patent/CN109311892B/zh active Active
- 2017-06-15 EP EP17812738.7A patent/EP3473625B1/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024193496A1 (zh) * | 2023-03-17 | 2024-09-26 | 北京普祺医药科技股份有限公司 | 吡咯并嘧啶化合物或其可药用盐的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3473625A1 (en) | 2019-04-24 |
| EP3473625B1 (en) | 2021-06-02 |
| ES2877678T3 (es) | 2021-11-17 |
| CN109311892A (zh) | 2019-02-05 |
| JP2019523772A (ja) | 2019-08-29 |
| US10766901B2 (en) | 2020-09-08 |
| JP6998896B2 (ja) | 2022-02-04 |
| CN109311892B (zh) | 2020-09-04 |
| WO2017215627A1 (zh) | 2017-12-21 |
| CN111875607A (zh) | 2020-11-03 |
| EP3473625A4 (en) | 2020-02-19 |
| US20190211021A1 (en) | 2019-07-11 |
| CN111875607B (zh) | 2021-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109311892B (zh) | 手性吡咯并嘧啶化合物的制备方法 | |
| CN108699063B (zh) | 一种芦可替尼的合成工艺 | |
| KR102236232B1 (ko) | Jak 저해제를 제조하기 위한 방법 및 중간생성물 | |
| JP7802770B2 (ja) | Ｊａｋ阻害剤を調製するための方法及び中間体 | |
| JP2009197016A (ja) | 医薬物質としての新規ピロール誘導体 | |
| CN118745175A (zh) | 一种氘代索托拉西布及其制备方法与应用 | |
| MD3658552T2 (ro) | Procedeu de obținere a N-(5-((4-(4-((dimetilamino)metil)-3-fenil-1H-pirazol-1-il)pirimidin-2-il)amino)-4-metoxi-2-morfolinofenil)acrilamidei prin prin reacţia aminei corespunzătoare cu clorură de 3-halo-propionil | |
| CN105541891A (zh) | 巴瑞替尼的中间体及其制备方法及由该中间体制备巴瑞替尼的方法 | |
| JPWO2014042176A1 (ja) | 縮合複素環誘導体の製造方法およびその製造中間体 | |
| CN102786525A (zh) | N-取代吡唑并[3,4-d]嘧啶酮类化合物、其制备方法及其应用 | |
| WO2022247676A1 (zh) | 一种二吡咯并吡啶结构的化合物、制备方法和医药用途 | |
| CN113336689A (zh) | 3-(α-氟乙烯基/羰基)吲哚类化合物的合成方法及抗癌活性 | |
| CN114957262B (zh) | 一种c-6位芳基化去氮嘌呤衍生物的制备方法 | |
| CN114848648B (zh) | C-6位芳基化去氮嘌呤衍生物在制备抗肿瘤药物中的应用 | |
| CN1077193A (zh) | N-5位-被保护的2，5-二氨基-4，6-二氯嘧啶及其生产方法 | |
| CN117603193A (zh) | 一种β-氰基吡唑类化合物的合成方法 | |
| CN112457231A (zh) | 一种拉罗替尼（Larotrectinib）中间体的消旋化方法 | |
| US12215110B2 (en) | Processes and intermediates for preparing a Btk inhibitor | |
| JP2013544787A (ja) | アザインダゾール誘導体の調製方法 | |
| CN114163445A (zh) | 拉罗替尼中间体及其制备方法 | |
| CN112279849A (zh) | 一种n-二氟甲基氮杂吲哚类化合物及其合成方法 | |
| TWI783985B (zh) | 類fms酪胺酸激酶抑制劑 | |
| WO2018099424A1 (zh) | 一种吡啶酮类衍生物的制备方法及其中间体 | |
| CN108191862B (zh) | 4-羟基-2-取代吡唑并吡啶类化合物的合成方法 | |
| TW201718480A (zh) | 尿素衍生物及其用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20190530 Address after: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province Applicant after: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Applicant after: Lianyungang Runzhong Pharmaceutical Co.,Ltd. Applicant after: Capital Pharmaceutical Holdings (Beijing) Co., Ltd. Address before: 222062 Yuzhou South Road, Haizhou District, Lianyungang, Jiangsu 369 Applicant before: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Applicant before: Lianyungang Runzhong Pharmaceutical Co.,Ltd. Applicant before: Beijing Centaurus Biopharma Technology Co., Ltd. |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171226 |