JP6998896B2 - キラルピロロピリミジン化合物の製造方法 - Google Patents
キラルピロロピリミジン化合物の製造方法 Download PDFInfo
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- JP6998896B2 JP6998896B2 JP2018565715A JP2018565715A JP6998896B2 JP 6998896 B2 JP6998896 B2 JP 6998896B2 JP 2018565715 A JP2018565715 A JP 2018565715A JP 2018565715 A JP2018565715 A JP 2018565715A JP 6998896 B2 JP6998896 B2 JP 6998896B2
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- 0 *[n]1c2ncnc(C(C#N)=*)c2cc1 Chemical compound *[n]1c2ncnc(C(C#N)=*)c2cc1 0.000 description 30
- ZGENDZDSLYKCSI-UHFFFAOYSA-N Nc1n[n](C(CC#N)C2CCCC2)cc1-c1c(cc[nH]2)c2ncn1 Chemical compound Nc1n[n](C(CC#N)C2CCCC2)cc1-c1c(cc[nH]2)c2ncn1 ZGENDZDSLYKCSI-UHFFFAOYSA-N 0.000 description 5
- WFMWIYMCLOLEQT-SSDOTTSWSA-N O=C(C1)NN[C@H]1C1CCCC1 Chemical compound O=C(C1)NN[C@H]1C1CCCC1 WFMWIYMCLOLEQT-SSDOTTSWSA-N 0.000 description 4
- QGCBRMWGRXYUBG-UHFFFAOYSA-N Nc1n[n](C(C2)(C2C#N)C2CCCC2)cc1-c1c(cc[nH]2)c2ncn1 Chemical compound Nc1n[n](C(C2)(C2C#N)C2CCCC2)cc1-c1c(cc[nH]2)c2ncn1 QGCBRMWGRXYUBG-UHFFFAOYSA-N 0.000 description 2
- ZGENDZDSLYKCSI-CQSZACIVSA-N Nc1n[n]([C@H](CC#N)C2CCCC2)cc1-c1c(cc[nH]2)c2ncn1 Chemical compound Nc1n[n]([C@H](CC#N)C2CCCC2)cc1-c1c(cc[nH]2)c2ncn1 ZGENDZDSLYKCSI-CQSZACIVSA-N 0.000 description 2
- PPXQRLKHKCUBIV-OAHLLOKOSA-N CN([C@H](CC#N)C1CCCC1)/N=C(\C(c1c(cc[nH]2)c2ncn1)=C)/N Chemical compound CN([C@H](CC#N)C1CCCC1)/N=C(\C(c1c(cc[nH]2)c2ncn1)=C)/N PPXQRLKHKCUBIV-OAHLLOKOSA-N 0.000 description 1
- GGSQEVSHCMLOID-OAHLLOKOSA-N C[n]1c2ncnc(-c3c[n]([C@H](CC#N)C4CCCC4)nc3N)c2cc1 Chemical compound C[n]1c2ncnc(-c3c[n]([C@H](CC#N)C4CCCC4)nc3N)c2cc1 GGSQEVSHCMLOID-OAHLLOKOSA-N 0.000 description 1
- QXURABBPFCIARR-CYBMUJFWSA-N NC(C[C@H](C1CCCC1)[n](cc1-c2c(cc[nH]3)c3ncn2)nc1N)=O Chemical compound NC(C[C@H](C1CCCC1)[n](cc1-c2c(cc[nH]3)c3ncn2)nc1N)=O QXURABBPFCIARR-CYBMUJFWSA-N 0.000 description 1
- MPRHIJJKVGFXRS-AATRIKPKSA-N OC(/C=C/C1CCCC1)=O Chemical compound OC(/C=C/C1CCCC1)=O MPRHIJJKVGFXRS-AATRIKPKSA-N 0.000 description 1
- SVNKRBFOWXGBDT-GVHYBUMESA-N OC(C1)NN[C@H]1C1=CCCC1 Chemical compound OC(C1)NN[C@H]1C1=CCCC1 SVNKRBFOWXGBDT-GVHYBUMESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610432126.5 | 2016-06-16 | ||
| CN201610432126.5A CN107513069A (zh) | 2016-06-16 | 2016-06-16 | 手性吡咯并嘧啶化合物的制备方法 |
| PCT/CN2017/088421 WO2017215627A1 (zh) | 2016-06-16 | 2017-06-15 | 手性吡咯并嘧啶化合物的制备方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523772A JP2019523772A (ja) | 2019-08-29 |
| JP2019523772A5 JP2019523772A5 (enExample) | 2020-05-21 |
| JP6998896B2 true JP6998896B2 (ja) | 2022-02-04 |
Family
ID=60663390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565715A Active JP6998896B2 (ja) | 2016-06-16 | 2017-06-15 | キラルピロロピリミジン化合物の製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10766901B2 (enExample) |
| EP (1) | EP3473625B1 (enExample) |
| JP (1) | JP6998896B2 (enExample) |
| CN (3) | CN107513069A (enExample) |
| ES (1) | ES2877678T3 (enExample) |
| WO (1) | WO2017215627A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022515272A (ja) * | 2018-12-24 | 2022-02-17 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | ピロロピリミジン化合物の治療的使用およびその固形医薬組成物 |
| CN114981272B (zh) * | 2020-03-09 | 2025-04-11 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物的治疗噬血细胞综合征的用途 |
| AU2021329301A1 (en) | 2020-08-18 | 2023-04-13 | Incyte Corporation | Process and intermediates for preparing a JAK1 inhibitor |
| KR20230096973A (ko) | 2020-08-18 | 2023-06-30 | 인사이트 코포레이션 | Jak 저해제를 제조하기 위한 방법 및 중간체 |
| CN114085224A (zh) * | 2020-08-25 | 2022-02-25 | 北京普祺医药科技有限公司 | 一种吡咯并嘧啶化合物的制备方法 |
| EP4361152A4 (en) | 2021-06-21 | 2025-05-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Use of a pyrrholopyrimidine compound and pharmaceutical composition thereof for the treatment of chronic graft-versus-host disease |
| CN118317946A (zh) | 2021-07-12 | 2024-07-09 | 因赛特公司 | 用于制备巴瑞替尼的方法和中间体 |
| WO2023179547A1 (zh) | 2022-03-21 | 2023-09-28 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物治疗中高危骨髓纤维化的用途 |
| CN119585277A (zh) | 2022-08-04 | 2025-03-07 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物治疗急性移植物抗宿主病的用途 |
| US20250215003A1 (en) * | 2022-08-22 | 2025-07-03 | Granules India Limited | An improved process for the preparation of ruxolitinib |
| CN120882718A (zh) * | 2023-03-17 | 2025-10-31 | 北京普祺医药科技股份有限公司 | 吡咯并嘧啶化合物或其可药用盐的制备方法 |
| WO2024230727A1 (zh) * | 2023-05-09 | 2024-11-14 | 正大天晴药业集团股份有限公司 | 一种吡咯并[2,3-c]吡啶酮化合物的联用药物组合物及其用途 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009519340A (ja) | 2005-12-13 | 2009-05-14 | インサイト・コーポレイション | ＪＡＮＵＳキナーゼ阻害剤としてのヘテロアリール置換ピロロ［２，３−ｂ］ピリジンおよびピロロ［２，３−ｂ］ピリミジン |
| CN105218548A (zh) | 2014-06-09 | 2016-01-06 | 上海海和药物研究开发有限公司 | 一种新型杂环化合物及其制备方法和作为激酶抑制剂的用途 |
| JP2016500119A (ja) | 2012-11-30 | 2016-01-07 | センタウルス・バイオファーマ・カンパニー・リミテッドＣｅｎｔａｕｒｕｓ Ｂｉｏｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | ブルトン型チロシンキナーゼ阻害剤 |
| JP2017537950A (ja) | 2014-12-16 | 2017-12-21 | ケンタウルス バイオファーマ カンパニー リミテッド | ピロロピリミジン化合物 |
| JP2019521980A (ja) | 2016-06-16 | 2019-08-08 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. | Ｊａｋ阻害剤としてのピロロピリミジン化合物の結晶 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5616499A (en) * | 1979-07-19 | 1981-02-17 | Yamasa Shoyu Co Ltd | 6-c-purine nucleoside derivative and its preparation |
| JPS5841897A (ja) * | 1981-09-04 | 1983-03-11 | Yamasa Shoyu Co Ltd | ６−（４−ピラゾリル）プリンリボヌクレオシド誘導体およびその製造法 |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| US20050008640A1 (en) | 2003-04-23 | 2005-01-13 | Wendy Waegell | Method of treating transplant rejection |
| JOP20190231A1 (ar) * | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| WO2011028685A1 (en) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| CN103739607A (zh) * | 2014-01-22 | 2014-04-23 | 无锡方圆环球显示技术股份有限公司 | 一种基于三并咔唑多臂结构红光材料及其制备方法与应用 |
| WO2015187470A1 (en) * | 2014-06-04 | 2015-12-10 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
| CN105315286B (zh) * | 2014-07-30 | 2018-08-17 | 连云港润众制药有限公司 | 西格列汀的制备 |
-
2016
- 2016-06-16 CN CN201610432126.5A patent/CN107513069A/zh active Pending
-
2017
- 2017-06-15 CN CN202010744086.4A patent/CN111875607B/zh active Active
- 2017-06-15 ES ES17812738T patent/ES2877678T3/es active Active
- 2017-06-15 US US16/309,882 patent/US10766901B2/en active Active
- 2017-06-15 EP EP17812738.7A patent/EP3473625B1/en active Active
- 2017-06-15 WO PCT/CN2017/088421 patent/WO2017215627A1/zh not_active Ceased
- 2017-06-15 JP JP2018565715A patent/JP6998896B2/ja active Active
- 2017-06-15 CN CN201780037151.6A patent/CN109311892B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009519340A (ja) | 2005-12-13 | 2009-05-14 | インサイト・コーポレイション | ＪＡＮＵＳキナーゼ阻害剤としてのヘテロアリール置換ピロロ［２，３−ｂ］ピリジンおよびピロロ［２，３−ｂ］ピリミジン |
| JP2016500119A (ja) | 2012-11-30 | 2016-01-07 | センタウルス・バイオファーマ・カンパニー・リミテッドＣｅｎｔａｕｒｕｓ Ｂｉｏｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | ブルトン型チロシンキナーゼ阻害剤 |
| CN105218548A (zh) | 2014-06-09 | 2016-01-06 | 上海海和药物研究开发有限公司 | 一种新型杂环化合物及其制备方法和作为激酶抑制剂的用途 |
| JP2017537950A (ja) | 2014-12-16 | 2017-12-21 | ケンタウルス バイオファーマ カンパニー リミテッド | ピロロピリミジン化合物 |
| JP6684803B2 (ja) | 2014-12-16 | 2020-04-22 | ケンタウルス バイオファーマ カンパニー リミテッド | ピロロピリミジン化合物 |
| JP2019521980A (ja) | 2016-06-16 | 2019-08-08 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. | Ｊａｋ阻害剤としてのピロロピリミジン化合物の結晶 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017215627A1 (zh) | 2017-12-21 |
| JP2019523772A (ja) | 2019-08-29 |
| CN107513069A (zh) | 2017-12-26 |
| EP3473625A1 (en) | 2019-04-24 |
| CN109311892A (zh) | 2019-02-05 |
| CN111875607B (zh) | 2021-12-03 |
| US20190211021A1 (en) | 2019-07-11 |
| CN109311892B (zh) | 2020-09-04 |
| ES2877678T3 (es) | 2021-11-17 |
| EP3473625B1 (en) | 2021-06-02 |
| US10766901B2 (en) | 2020-09-08 |
| EP3473625A4 (en) | 2020-02-19 |
| CN111875607A (zh) | 2020-11-03 |
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