JPS5616499A - 6-c-purine nucleoside derivative and its preparation - Google Patents

6-c-purine nucleoside derivative and its preparation

Info

Publication number
JPS5616499A
JPS5616499A JP9204879A JP9204879A JPS5616499A JP S5616499 A JPS5616499 A JP S5616499A JP 9204879 A JP9204879 A JP 9204879A JP 9204879 A JP9204879 A JP 9204879A JP S5616499 A JPS5616499 A JP S5616499A
Authority
JP
Japan
Prior art keywords
formula
ribofuranosylpurin
acrylonitrile
preparation
purine nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9204879A
Other languages
Japanese (ja)
Inventor
Sada Miyasaka
Hiroshi Suemune
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP9204879A priority Critical patent/JPS5616499A/en
Publication of JPS5616499A publication Critical patent/JPS5616499A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A 3-substituted amino-2-(9-β-D-ribofuranosylpurin-6-yl)-acrylonitrile expressed by formula I [R1 is (substituted) alkylamino, dialkylamino, aralkylamino, allylamino, pyrrolidino, piperidino or morpholino group; R2 is H or protecting group].
EXAMPLE: 3-( N-Monomethylamino )-2-( 9-β-D-ribofuranosylpurin-6-yl )-acrylonitrile.
USE: A peripheral vasodilator, an antiallergic and an antitumor agents.
PROCESS: A 3-amino-2-(9-β-D-ribofuranosylpurin-6-yl)-acrylonitrile of formula II (R2' is protecting group) is reacted with an amine of the formula R1H, preferably in a mixed solvent of an alcohol with dioxane, under heating to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP9204879A 1979-07-19 1979-07-19 6-c-purine nucleoside derivative and its preparation Pending JPS5616499A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9204879A JPS5616499A (en) 1979-07-19 1979-07-19 6-c-purine nucleoside derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9204879A JPS5616499A (en) 1979-07-19 1979-07-19 6-c-purine nucleoside derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5616499A true JPS5616499A (en) 1981-02-17

Family

ID=14043623

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9204879A Pending JPS5616499A (en) 1979-07-19 1979-07-19 6-c-purine nucleoside derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5616499A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6191822A (en) * 1984-10-05 1986-05-09 エヌ・ベー・フイリツプス・フルーイランペンフアブリケン Manufacture of scandium dispensor cathode and dispensor cathode manufactured thereby
JPH0850849A (en) * 1994-05-31 1996-02-20 Nec Kansai Ltd Cathode member and electronic tube using it
CN111875607A (en) * 2016-06-16 2020-11-03 正大天晴药业集团股份有限公司 Preparation method of chiral pyrrolopyrimidine compound

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6191822A (en) * 1984-10-05 1986-05-09 エヌ・ベー・フイリツプス・フルーイランペンフアブリケン Manufacture of scandium dispensor cathode and dispensor cathode manufactured thereby
JPH0850849A (en) * 1994-05-31 1996-02-20 Nec Kansai Ltd Cathode member and electronic tube using it
CN111875607A (en) * 2016-06-16 2020-11-03 正大天晴药业集团股份有限公司 Preparation method of chiral pyrrolopyrimidine compound

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