CN107397909A - 一种治疗再生障碍性贫血的药物及其制备方法 - Google Patents
一种治疗再生障碍性贫血的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗再生障碍性贫血的药物及其制备方法,它主要是由红绵藤、昆明鸡血藤、红紫珠、鸡血藤、血藤、阿胶、三七、西洋参、当归、秦艽、丹参、茯苓、红花、芸香草、苣荬菜、杜仲、芒果叶、鹿茸、还阳参、赤小豆、大枣、地榆、仙鹤草、何首乌、鹿角胶、龟版胶、沙苑子、没食子、补骨脂、灵芝草、鸡肝、鸡屎白、青鱼胆、熊胆、刺五加、猪胆、牛胆、金果榄、黄芪、黄精、石斛按一定重量配比制备而成,本发明具有补血和血、养血祛风、理气化湿、润燥滑肠、清热解毒、壮元阳、益精髓的功能,用于治疗再生障碍性贫血见效快,疗效好。
Description
技术领域
本发明涉及一种治疗再生障碍性贫血的药物及其制备方法,属中药领域。
技术背景
再生障碍性贫血是一组由多种病因所致的骨髓造血功能衰竭性综合征,以骨髓造血细胞增生减低和外周血全血细胞减少为特征。中医则认为再生障碍性贫血与气血两虚、肾虚血瘀、肾阴阳两虚、热毒壅盛有关。由于西药治疗副作用大,因此人们对有效治疗再生障碍性贫血的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于研究出有效治疗再生障碍性贫血的药物,从而完成了本发明。
本发明的目的就是提供一种更有效的治疗再生障碍性贫血的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择红绵藤、昆明鸡血藤、红紫珠、鸡血藤、血藤、阿胶、三七、西洋参、当归、秦艽、丹参、茯苓、红花、芸香草、苣荬菜、杜仲、芒果叶、鹿茸、还阳参、赤小豆、大枣、地榆、仙鹤草、何首乌、鹿角胶、龟版胶、沙苑子、没食子、补骨脂、灵芝草、鸡肝、鸡屎白、青鱼胆、熊胆、刺五加、猪胆、牛胆、金果榄、黄芪、黄精、石斛、石决明、龙齿、牡蛎进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗再生障碍性贫血。其中选用红绵藤是因为其性味涩,性平,归肝经,有收敛止血的功能,治外科手术及外伤性出血,消化道出血,呼吸道出血,泌尿系统出血,妇科出血以及血液病引起的出血。。选用昆明鸡血藤是因为其性味苦,温,有养血祛风,通经活络的功能,治腰膝酸痛麻木,遗精,盗汗,月经不调,跌打损伤。选用红紫珠是因为其有接骨的功能,治跌打。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用血藤是因为其性味辛酸,温,有养血消瘀,理气化湿的功能,治痨伤出血,肢节酸疼,心胃气痛,脚气痿痹,月经不调,跌打损伤。选用阿胶是因为其性味甘平,入肺、肝、肾经,有滋阴补血,安胎的功能,治血虚,虚劳咳嗽,吐血、衄血、便血,妇女月经不调,崩中,治漏。选用三七是因为其性味甘微苦,温,入肝、胃、大肠经,有止血,散瘀,消肿,定痛的功能,治吐血,咳血,衄血,便血,血痢,崩漏,癥瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛。选用西洋参是因为其性味甘微苦,凉,入心、肺、肾三经,有益肺阴,清虚火,生津止渴的功能,治肺虚久嗽,失血,咽干口渴,虚热烦倦。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利,水肿胀满,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用芸香草是因为其性味辛苦,凉,有解表,利湿,平喘,止咳的功能,治伤暑感冒,淋病,风湿筋骨酸痛,慢性气管炎。选用苣荬菜是因为其性寒,味苦,有清热解毒,补虚止咳的功能,治菌痢,喉炎,虚弱咳嗽,内痔脱出,白带。选用杜仲是因为其性味甘微辛,温,入肝、肾经,有补肝肾,强筋骨,安胎的功能,治腰脊酸疼,足膝痿弱,小便余沥,阴下湿痒,胎漏欲堕,高血压。选用芒果叶是因为其性平、味微酸,有消积滞、疏风止咳的功能。选用鹿茸是因为其性味甘咸,温,入肝、肾经,有壮元阳,补气血,益精髓,强筋骨的功能,治虚劳羸瘦,精神倦乏,眩晕,耳聋,目暗,腰膝酸痛,阳痿,滑精;子宫虚冷,崩漏,带下。选用还阳参是因为其性温平,味甘,有补肾阳,益气血,健脾胃的功能,治性神经衰弱,妇人宫冷不孕,白带漏下,头晕耳鸣,心慌怔忡,小儿消化及营养不良。选用赤小豆是因为其性味甘酸,平,入心、小肠经,有利水除湿,和血排脓,消肿解毒的功能,治水肿,脚气,黄疸,泻痢,便血,痈肿。选用大枣是因为其性味甘,温,入脾、胃经,有补脾和胃,益气生津,调营卫,解药毒的功能,治胃虚食少,脾弱便溏,气血津液不足,营卫不和,心悸怔忡,妇人脏躁。选用地榆是因为其性味苦酸,寒,入肝、大肠经,有凉血止血,清热解毒的功能,治吐血,衄血,血痢,崩漏,肠风,痔漏,痈肿,湿疹,金疮,烧伤。选用仙鹤草是因为其性味苦辛,平,入肺、肝、脾经,有止血,健胃的功能,治咯血,吐血,尿血,便血,赤白痢疾,崩漏带下,劳伤脱力,痈肿,跌打、创伤出血。选用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰疬,肠风,痔疾。选用鹿角胶是因为其性味甘咸,温,入肝、肾经,有补血,益精的功能,治肾气不足,虚劳羸瘦,腰痛,阴疽,男子阳痿、滑精,妇女子宫虚冷,崩漏,带下。选用龟版胶是因为其性味甘咸,平,有滋阴,补血,止血的功能,治阴虚血亏,劳热骨蒸,吐血,衄血,烦热惊悸,肾虚腰痛,脚膝痿弱,崩漏,带下。选用沙苑子是因为其性味甘温,入肝、肾经,有补肝,益肾,明目,固精的功能,治肝肾不足,腰膝酸痛,目昏,遗精早泄,小便频数,遗尿,尿血,白带。选用没食子是因为其性味苦,温,入肺、脾、肾经,有固气,涩精,敛肺,止血的功能,治大肠虚滑,泻痢不止,便血,遗精,阴汗,咳嗽,咯血,齿痛,创伤出血,疮疡久不收口。选用补骨脂是因为其性味辛,温,入肾经,有补肾助阳的功能,治肾虚冷泻,遗尿,滑精,小便频数,阳痿,腰膝冷痛,虚寒喘嗽,外用治白癜风。选用灵芝草是因为其性味甘,平,治虚劳,咳嗽,气喘,失眠,消化不良。选用鸡肝是因为其性味甘,微温,入足厥阴、少阴经,有补肝肾的功能,治肝虚目暗,小儿疳积,妇人胎漏。选用鸡屎白是因为其性味苦咸,凉,入膀胱经,有利水,泄热,祛风,解毒的功能,治臌胀积聚,黄疸,淋病,风痹,破伤中风, 筋脉挛急。选用青鱼胆是因为其性味苦,寒,无毒,入肝、胆经,有泻热,明目的功能,治目赤肿痛,翳障,喉痹,热疮。选用熊胆是因为其性味苦,寒,入肝、胆、脾、胃经,有清热,镇痉,明目,杀虫的功能,治热黄,暑泻,小儿惊癎,疳疾,蛔虫痛,目翳,喉痹,鼻蚀,疔痔恶疮。选用刺五加是因为其性味辛、微苦,温,归脾、肾、心经,有益气健脾,补肾安神的功能,治脾肾阳虚,体虚乏力,食欲不振,腰膝酸痛,失眠多梦。选用猪胆是因为其性味苦,寒,入肝、胆、肺、大肠经,有清热,润燥,解毒的功能,治热病里热燥渴、便秘,黄疸,百日咳,哮喘,泄泻,痢疾,目赤,喉痹,聤耳,痈肿疔疮。选用牛胆是因为其性味苦,大寒,入肝、胆、肺三经,有清肝明目,利胆通肠,解毒消肿的功能,治风热目疾,黄疸,便秘,消渴,小儿惊风,痈肿,痔疮。选用金果榄是因为其性味苦,寒,入脾、肾二经,有清热解毒的功能,治急慢性扁桃体炎,急性咽喉炎,口腔炎,腮腺炎,乳腺炎,阑尾炎,痈疽疔疮,急慢性肠炎,菌痢,胃痛,热嗽失音。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用黄精是因为其性味甘平,入脾、肺、肾经,有补中益气,润心肺,强筋骨的功能,治虚损寒热,肺痨咳血,病后体虚食少,筋骨软弱,风湿疼痛,风癞癣疾。选用石斛是因为其性味甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用石决明是因为其性味咸,平,入肝、肾经,有平肝潜阳,除热,明目的功能,治风阳上扰、头痛眩晕,惊搐,骨蒸劳热,青盲内障。选用龙齿是因为其性味涩,凉,入心、肝经,有镇惊安神,除烦热的功能,治惊癎癫狂,烦热不安,失眠多梦。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化痰,软坚的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,瘿瘤。
具体实施方式
本发明组方的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
红绵藤15-25克、昆明鸡血藤30-40克、红紫珠60-70克、鸡血藤25-35克、血藤30-40克、阿胶10-20克、三七5-10克、西洋参10-15克、当归10-20克、秦艽10-20克、丹参25-35克、茯苓20-30克、红花10-20克、芸香草30-40克、苣荬菜5-15克、杜仲15-25克、芒果叶25-35克、鹿茸3-9克、还阳参10-20克、赤小豆35-45克、大枣15-25克、地榆10-20克、仙鹤草35-35克、何首乌10-15克、鹿角胶10-15克、龟版胶15-25克、沙苑子5-10克、没食子10-15克、补骨脂10-15克、灵芝草3-9克、鸡肝75-85克、鸡屎白3-9克、青鱼胆3-9克、熊胆1-3克、刺五加20-30克、猪胆3-7克、牛胆3-7克、金果榄3-9克、黄芪25-35克、黄精10-15克、石斛10-15克、石决明20-30克、龙齿10-20克、牡蛎25-35克。
优选为:
红绵藤20克、昆明鸡血藤35克、红紫珠65克、鸡血藤30克、血藤35克、阿胶15克、三七8克、西洋参12克、当归15克、秦艽15克、丹参30克、茯苓25克、红花15克、芸香草35克、苣荬菜10克、杜仲20克、芒果叶30克、鹿茸6克、还阳参15克、赤小豆40克、大枣20克、地榆15克、仙鹤草30克、何首乌12克、鹿角胶12克、龟版胶20克、沙苑子8克、没食子12克、补骨脂12克、灵芝草6克、鸡肝80克、鸡屎白6克、青鱼胆6克、熊胆2克、刺五加25克、猪胆5克、牛胆5克、金果榄6克、黄芪30克、黄精12克、石斛12克、石决明25克、龙齿15克、牡蛎30克。
本发明药物的制备方法如下:
一、备料
1、红绵藤:拣净杂质,洗净,晒干;
2、昆明鸡血藤:用水洗净,润透,切成2.5厘米长,1.5厘米厚的斜片,晒干;
3、红紫珠:拣净杂质,晒干;
4、鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
5、血藤:水浸润透,切片,晒干;
6、阿胶:捣碎用;
7、三七:拣净杂质,捣碎,研末或润透后切片晒干;
8、西洋参:原药用清水喷潮,覆盖湿布,夏秋润2天,冬春润3天,取出切片,晾干;
9、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
10、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
11、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
12、茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
13、红花:拣净杂质,除去茎叶、蒂头,晒干;
14、芸香草:夏末秋初割取地上部分,晒干;
15、苣荬菜:春季开花前连根拔起,洗净,晒干;
16、杜仲:除去粗皮,洗净,润透,切成方块或丝条,晒干;
17、芒果叶:拣净杂质,晒干;
18、鹿茸:用干燥的鹿茸片,碾成细末;
19、还阳参:秋季采收,晒干;
20、赤小豆:取原药材,除去杂质,用时捣碎;
21、大枣:拣净杂质,晒干;
22、地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
23、仙鹤草:除去杂质残根,洗净,润透,切断,晒干;
24、何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
25、鹿角胶:取原药材,除去杂质,用时捣碎或研粉;
26、龟版胶:取漂泡后的净龟版,置锅中水煎数次,煎至胶质尽,去滓,将多次煎出的胶液,过滤合并,加入少许明矾粉,静置,滤取澄清的胶液,用文火浓缩(或可加入适量的黄酒、冰糖)呈至稠膏状,倾入凝胶槽内,使其冷凝后取出,切成小块,阴干;
27、沙苑子:拣去杂质,漂净泥沙,捞出,晒干;
28、没食子:洗净,晒干,捣碎;
29、补骨脂:簸净杂质,洗净,晒干;
30、灵芝草:除去杂质,洗净,润软,切厚片,干燥,筛去碎屑;
31、鸡肝:杀鸡取原品,洗净;
32、鸡屎白:晒干,文火焙炒,炒时洒入白洒少许,研末;
33、青鱼胆:青鱼剖腹后,割取胆囊,悬挂通风处阴干;
34、熊胆:去净皮膜,研成细末;
35、刺五加:除去杂质,大小分档,浸泡,润透,切厚片,干燥,筛去碎屑;
36、猪胆:将鲜猪胆挂起晾干,或在半干时,稍稍压扁,再干燥之;
37、牛胆:从宰牛场收集,取得后挂起阴干或自胆管处剪开,将胆汁倾入容器内,阴干,密封贮藏;
38、金果榄:去净杂质,用水浸泡,约七成透,取出,待润至内外湿度均匀,切片或切成小块,晒干;
39、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡;
40、黄精:洗净泥土,略润,切片,晒干;
41、石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒干;
42、石决明:洗净晾干,敲成碎块;
43、龙齿:刷净泥土,打碎;
44、牡蛎:洗净,晒干,打碎用。
二、制备
1、取阿胶、鹿角胶、龟版胶、熊胆、鹿茸、西洋参、鸡肝、三七置于容器内捣碎;
2、将红绵藤、昆明鸡血藤、红紫珠、鸡血藤、血藤、当归、秦艽、丹参、茯苓、红花、芸香草、苣荬菜、杜仲、芒果叶、还阳参、赤小豆、大枣、地榆、仙鹤草、何首乌、沙苑子、没食子、补骨脂、灵芝草、鸡屎白、青鱼胆、刺五加、猪胆、牛胆、金果榄、黄芪、黄精、石斛、石决明、龙齿、牡蛎磨成碎药粉;
3、另取麻油400克置于煎药容器内加热15分钟,再加入上述磨碎药粉,武火煮至药渣全黑色时,过滤去除去药渣;
4、再用文火煎煮35分钟,加入炼蜜350克煮6分钟,再加入捣碎的阿胶、鹿角胶、龟版胶、熊胆、鹿茸、西洋参、鸡肝、三七,混合搅拌均匀后,再煎煮5分钟,待温,制成高粮米大小的颗粒,置阴凉处阴干即得丸剂。
组方中红绵藤收敛止血,昆明鸡血藤有养血祛风,通经活络的功能二者为君药;血藤养血消瘀,理气化湿,当归有补血和血,调经止痛,润燥滑肠的功能,与红紫珠、鸡血藤、阿胶、三七、西洋参五者为臣药,九味药共同发挥补血和血、养血祛风,通经活络,理气化湿、润燥滑肠的作用,治疗再生障碍性贫血效力全面,且以补血和血、养血祛风、理气化湿、润燥滑肠为主,可治本;鹿茸有壮元阳,补气血,益精髓,强筋骨的功能与秦艽、丹参、茯苓、红花、芸香草、苣荬菜、杜仲、芒果叶、还阳参、赤小豆、大枣、地榆、仙鹤草、何首乌、鹿角胶为佐药;金果榄有清热解毒的功能与余下诸药为使药,是治标。
本发明药物具有补血和血、养血祛风、理气化湿、润燥滑肠、清热解毒、壮元阳、益精髓的功能,用于治疗再生障碍性贫血见效快,疗效好。
以下通过试验例来进一步阐述本发明药物的有益效果,这些试验包括本发明药物的动物毒性试验和临床疗效观察试验。
[试验例1]本发明药物的动物毒性试验
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为0.3g/kg,正常量为0.15g/kg,给药方式为稀释灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治门诊患者共41例。
2、诊断标准
再生障碍性贫血的症状包括:出血、贫血、易引发感染。
3、治疗方法
选用上述药剂,给患者服用,每次8克,未成年人减半,每天早、晚各一次,30天为一个疗程,连续使用4个疗程。
4、疗效评定标准
显效:再生障碍性贫血症状消失,恢复正常,痊愈;
好转:患者出血、贫血、易引发感染的现象减轻,再生障碍性贫血症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表):
在上述治疗中,用本发明药物治疗再生障碍性贫血患者41例,结果显效35例,显效率为85.37%,好转4例,好转率为9.75%,无效2例,总有效率为95.12%。
Claims (3)
1.一种治疗再生障碍性贫血的药物,其特征在于:它是由下列重量范围内的原料药制成:
红绵藤15-25克、昆明鸡血藤30-40克、红紫珠60-70克、鸡血藤25-35克、血藤30-40克、阿胶10-20克、三七5-10克、西洋参10-15克、当归10-20克、秦艽10-20克、丹参25-35克、茯苓20-30克、红花10-20克、芸香草30-40克、苣荬菜5-15克、杜仲15-25克、芒果叶25-35克、鹿茸3-9克、还阳参10-20克、赤小豆35-45克、大枣15-25克、地榆10-20克、仙鹤草35-35克、何首乌10-15克、鹿角胶10-15克、龟版胶15-25克、沙苑子5-10克、没食子10-15克、补骨脂10-15克、灵芝草3-9克、鸡肝75-85克、鸡屎白3-9克、青鱼胆3-9克、熊胆1-3克、刺五加20-30克、猪胆3-7克、牛胆3-7克、金果榄3-9克、黄芪25-35克、黄精10-15克、石斛10-15克、石决明20-30克、龙齿10-20克、牡蛎25-35克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
红绵藤20克、昆明鸡血藤35克、红紫珠65克、鸡血藤30克、血藤35克、阿胶15克、三七8克、西洋参12克、当归15克、秦艽15克、丹参30克、茯苓25克、红花15克、芸香草35克、苣荬菜10克、杜仲20克、芒果叶30克、鹿茸6克、还阳参15克、赤小豆40克、大枣20克、地榆15克、仙鹤草30克、何首乌12克、鹿角胶12克、龟版胶20克、沙苑子8克、没食子12克、补骨脂12克、灵芝草6克、鸡肝80克、鸡屎白6克、青鱼胆6克、熊胆2克、刺五加25克、猪胆5克、牛胆5克、金果榄6克、黄芪30克、黄精12克、石斛12克、石决明25克、龙齿15克、牡蛎30克。
3.根据权利要求1或2所述药物的制备方法,其特征在于:它包括下列步骤:
(一)备料
(1)红绵藤:拣净杂质,洗净,晒干;
(2)昆明鸡血藤:用水洗净,润透,切成2.5厘米长,1.5厘米厚的斜片,晒干;
(3)红紫珠:拣净杂质,晒干;
(4)鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
(5)血藤:水浸润透,切片,晒干;
(6)阿胶:捣碎用;
(7)三七:拣净杂质,捣碎,研末或润透后切片晒干;
(8)西洋参:原药用清水喷潮,覆盖湿布,夏秋润2天,冬春润3天,取出切片,晾干;
(9)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(10)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(11)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(12)茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
(13)红花:拣净杂质,除去茎叶、蒂头,晒干;
(14)芸香草:夏末秋初割取地上部分,晒干;
(15)苣荬菜:春季开花前连根拔起,洗净,晒干;
(16)杜仲:除去粗皮,洗净,润透,切成方块或丝条,晒干;
(17)芒果叶:拣净杂质,晒干;
(18)鹿茸:用干燥的鹿茸片,碾成细末;
(19)还阳参:秋季采收,晒干;
(20)赤小豆:取原药材,除去杂质,用时捣碎;
(21)大枣:拣净杂质,晒干;
(22)地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
(23)仙鹤草:除去杂质残根,洗净,润透,切断,晒干;
(24)何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
(25)鹿角胶:取原药材,除去杂质,用时捣碎或研粉;
(26)龟版胶:取漂泡后的净龟版,置锅中水煎数次,煎至胶质尽,去滓,将多次煎出的胶液,过滤合并,加入少许明矾粉,静置,滤取澄清的胶液,用文火浓缩(或可加入适量的黄酒、冰糖)呈至稠膏状,倾入凝胶槽内,使其冷凝后取出,切成小块,阴干;
(27)沙苑子:拣去杂质,漂净泥沙,捞出,晒干;
(28)没食子:洗净,晒干,捣碎;
(29)补骨脂:簸净杂质,洗净,晒干;
(30)灵芝草:除去杂质,洗净,润软,切厚片,干燥,筛去碎屑;
(31)鸡肝:杀鸡取原品,洗净;
(32)鸡屎白:晒干,文火焙炒,炒时洒入白洒少许,研末;
(33)青鱼胆:青鱼剖腹后,割取胆囊,悬挂通风处阴干;
(34)熊胆:去净皮膜,研成细末;
(35)刺五加:除去杂质,大小分档,浸泡,润透,切厚片,干燥,筛去碎屑;
(36)猪胆:将鲜猪胆挂起晾干,或在半干时,稍稍压扁,再干燥之;
(37)牛胆:从宰牛场收集,取得后挂起阴干或自胆管处剪开,将胆汁倾入容器内,阴干,密封贮藏;
(38)金果榄:去净杂质,用水浸泡,约七成透,取出,待润至内外湿度均匀,切片或切成小块,晒干;
(39)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡;
(40)黄精:洗净泥土,略润,切片,晒干;
(41)石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒干;
(42)石决明:洗净晾干,敲成碎块;
(43)龙齿:刷净泥土,打碎;
(44)牡蛎:洗净,晒干,打碎用;
(二)制备
(1)取阿胶、鹿角胶、龟版胶、熊胆、鹿茸、西洋参、鸡肝、三七置于容器内捣碎;
(2)将红绵藤、昆明鸡血藤、红紫珠、鸡血藤、血藤、当归、秦艽、丹参、茯苓、红花、芸香草、苣荬菜、杜仲、芒果叶、还阳参、赤小豆、大枣、地榆、仙鹤草、何首乌、沙苑子、没食子、补骨脂、灵芝草、鸡屎白、青鱼胆、刺五加、猪胆、牛胆、金果榄、黄芪、黄精、石斛、石决明、龙齿、牡蛎磨成碎药粉;
(3)另取麻油400克置于煎药容器内加热15分钟,再加入上述磨碎药粉,武火煮至药渣全黑色时,过滤去除去药渣;
(4)再用文火煎煮35分钟,加入炼蜜350克煮6分钟,再加入捣碎的阿胶、鹿角胶、龟版胶、熊胆、鹿茸、西洋参、鸡肝、三七,混合搅拌均匀后,再煎煮5分钟,待温,制成高粮米大小的颗粒,置阴凉处阴干即得丸剂。
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