CN107260819A - 一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法 - Google Patents
一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法 Download PDFInfo
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- CN107260819A CN107260819A CN201710652476.7A CN201710652476A CN107260819A CN 107260819 A CN107260819 A CN 107260819A CN 201710652476 A CN201710652476 A CN 201710652476A CN 107260819 A CN107260819 A CN 107260819A
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- cordyceps sinensis
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- hide gelatin
- donkey
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Abstract
本发明提供了一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，其特征在于，包括将虫草粉碎、过筛、烘干得虫草粉，向虫草粉中加入蒸馏水，通过水热浸提法提取虫草素；再以提取后的剩余物为原料，提取虫草多肽；通过超声法提取虫草多糖，将其与黄伞多糖混合，协同抗氧化；将阿胶用粉碎机粉碎成可直接入药的细粉，向黄连、黄芩、白芍中加水煎煮提取，再与阿胶细粉混合；将多种原料与上述所得物料混合均匀，边搅拌边滴加粘合剂食用酒精，制成软硬适中的材料；将混合制成的软材紧握成团，过筛、干燥，再过筛、烘干，加入山梨糖醇、润滑剂硬脂酸镁，混合均匀，用单冲压片机压片，按生产规格进行包装。
Description
技术领域
本发明涉及保健品领域，具体涉及一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法。
背景技术
虫草又称北冬虫夏草，虫草天然资源的世界性分布数量很少。虫草是我国传统的食药用菌类，具有很高的药用价值，具有丰富的生物活性物质和显著的药理作用。虫草主要的活性成分主要是腺苷类、虫草素、虫草酸、虫草多糖、甘露醇、酶、麦角留醇、甾醇类等多种活性成分，同时含有多种蛋白质、氨基酸、维生素以及微量元素。一系列研究结果表明虫草具有降三高、增强免疫力、镇定催眠、防治衰老、抗氧化、抗疲劳、抗病毒、抗肿瘤和保护心肺组织等功效，同时具有辅助治疗心血管疾病、肾功能障碍、肝脏疾病、缓解肺癌等作用。从虫草子座中分离得到的虫草多肽具有抗菌、抗癌和免疫增强作用。众所周知，多肽是机体完成各种生理活性必不可少的一种物质，在生物的代谢活动和疾病治疗中也起着不可取代的作用。
发明内容
本发明提供了一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，依照该工艺制备的片剂具有良好的抗氧化活性、能补气血、美容养颜。
本发明采用如下技术方案：
一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，其特征在于，由以下步骤制成：
（1）将15-25重量份虫草用中药粉碎机粉碎，过80-100目筛，在40-50℃的烘箱中烘干，得到虫草粉，匀分成两份，待用；
水热浸提法提取虫草素：
向一份虫草粉中1:15-20加入蒸馏水，充分搅拌均匀，置于55-60℃水浴中，浸提2-3次，每次5-6h，离心，取上层清液，得到含虫草素的滤液； 虫草剩余物直接酶解：
向上述离心后的虫草剩余物中1:10-15加入蒸馏水，用NaOH调溶液pH为10-12，加入碱性蛋白酶，在50-60℃下恒温酶解8-12h后，置于沸水浴中灭酶10-20min，抽滤，得到含虫草多肽的滤液；
（2）超声法提取虫草多糖：
向（1）中所得另一份虫草粉中1:30-40加入蒸馏水，混匀浸泡，在50-55℃下超声提取40-50min，离心，将上清液浓缩、冷却，边搅拌边加入乙醇，于4-6℃静置过夜，离心、沉淀用乙醚、丙酮洗涤3-5次后，放入60-70℃干燥箱中烘干至恒重，得到虫草多糖；将其与黄伞多糖3-2:1混合待用；
（3）将7-13重量份阿胶用粉碎机粉碎，过80-100目筛，得到可直接入药的阿胶细粉；
将6-8重量份黄连、3-4重量份黄芩、4-5重量份白芍混合，1:15-20加入蒸馏水，密封放置，浸泡1-2h，加热至70-80℃回流提取1-2h，过滤，将滤液浓缩至相对密度为1.2-1.3的清膏，在75-85℃下减压干燥至恒重，冷却，粉碎成细粉，与阿胶细粉混合待用；
（4）复方虫草人参阿胶片的制备：
将5-10重量份枸杞子、10-15重量份茯苓、3-5重量份陈皮、3-4重量份益智仁混合，研磨粉碎，过80-100目筛后，与2-4重量份甘草浸膏、2-3重量份肉桂粉、2-4重量份怀山药粉、1-2重量份人参粉及(1)、(2)、(3)中所得物料混合，加入1-2重量份麦芽糊精、2-4重量份食用葡萄糖，混合均匀，缓慢加入粘合剂食用酒精，边滴加边搅拌，制成软硬适中的材料；
将混合制成的软材紧握成团，过18-20目筛，于65-75℃干燥30-40min，过18-20目筛，再置于65-75℃烘箱内烘干20-30min，加入1-2重量份山梨糖醇、0.5-1重量份润滑剂硬脂酸镁，混合均匀，用单冲压片机压片，按生产规格进行包装。
其中，步骤（1）中所述虫草为广东虫草子实体，离心为3000-4000rpm处理10-20min，NaOH浓度为1-2%，碱性蛋白酶的用量为8000-10000U/g。步骤（2）中所述乙醇浓度为90-95%，离心为6000-7000rpm处理5-10min。步骤（4）中所述干燥后物料含水量为3-5%，每片重0.4-0.5g。
本发明的有益效果：
将虫草粉碎、过筛、烘干后得到虫草粉，用水热浸提法提取得到具有抗氧化、防治衰老功效的虫草素；以热水浸提虫草素后的剩余物为原料，用碱性蛋白酶直接进行酶解，得到具有清除自由基、抗脂质过氧化能力的虫草酶解液多肽；运用超声法对虫草粉进行提取得到具有抗氧化活性的虫草多糖，将其与黄伞多糖复合后具有协同抗氧化作用，对DPPH和H2O2的清除能力较强。
将阿胶粉碎成细粉可直接入药，将黄连、黄芩、白芍用水煎煮提取，再与其他原料混合制粒、压片，得到压片糖果，即虫草人参阿胶片，能补气血、美容养颜。
具体实施方式
下面通过具体的实施例对本发明做进一步的详细描述，不是对本发明的限制。
实施例
一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，包括以下步骤：
（1）将25g虫草用中药粉碎机粉碎，过100目筛，在40-50℃的烘箱中烘干，得到虫草粉，匀分成两份，待用；
水热浸提法提取虫草素：
向一份虫草粉中1:20加入蒸馏水，充分搅拌均匀，置于55-60℃水浴中，浸提2次，每次5h，离心，取上层清液，得到含虫草素的滤液； 虫草剩余物直接酶解：
向上述离心后的虫草剩余物中1:15加入蒸馏水，用NaOH调溶液pH为10-12，加入碱性蛋白酶，在50-60℃下恒温酶解8h后，置于沸水浴中灭酶15min，抽滤，得到含虫草多肽的滤液；
（2）超声法提取虫草多糖：
向（1）中所得另一份虫草粉中1:35加入蒸馏水，混匀浸泡，在50-55℃下超声提取45min，离心，将上清液浓缩、冷却，边搅拌边加入乙醇，于4-6℃静置过夜，离心、沉淀用乙醚、丙酮洗涤3次后，放入60-70℃干燥箱中烘干至恒重，得到虫草多糖；将其与黄伞多糖3:1混合待用；
（3）将13g阿胶用粉碎机粉碎，过100目筛，得到可直接入药的阿胶细粉；
将6g黄连、3g黄芩、4g白芍混合，1:20加入蒸馏水，密封放置，浸泡1h，加热至70-80℃回流提取2h，过滤，将滤液浓缩至相对密度为1.2-1.3的清膏，在75-85℃下减压干燥至恒重，冷却，粉碎成细粉，与阿胶细粉混合待用；
（4）复方虫草人参阿胶片的制备：
将5g枸杞子、10g茯苓、3g陈皮、3g益智仁混合，研磨粉碎，过100目筛后，与4g甘草浸膏、2g肉桂粉、4g怀山药粉、2g人参粉及(1)、(2)、(3)中所得物料混合，加入1g麦芽糊精、4g食用葡萄糖，混合均匀，缓慢加入粘合剂食用酒精，边滴加边搅拌，制成软硬适中的材料；
将混合制成的软材紧握成团，过18目筛，于65-75℃干燥35min，过20目筛，再置于65-75℃烘箱内烘干25min，加入2g山梨糖醇、0.5g润滑剂硬脂酸镁，混合均匀，用单冲压片机压片，按生产规格进行包装。
其中，步骤（1）中所述虫草为广东虫草子实体，离心为3500rpm处理15min，NaOH浓度为1.5%，碱性蛋白酶的用量为9000U/g。步骤（2）中所述乙醇浓度为90%，离心为6500rpm处理10min。步骤（4）中所述干燥后物料含水量为5%，每片重0.4g。
Claims (5)
1.一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，其特征在于，包括将虫草粉碎、过筛、烘干得虫草粉，向虫草粉中加入蒸馏水，通过水热浸提法提取虫草素；再以提取后的剩余物为原料，提取虫草多肽；通过超声法提取虫草多糖，将其与黄伞多糖混合，协同抗氧化；将阿胶用粉碎机粉碎成可直接入药的细粉，向黄连、黄芩、白芍中加水煎煮提取，再与阿胶细粉混合；将多种原料与上述所得物料混合均匀，边搅拌边滴加粘合剂食用酒精，制成软硬适中的材料；将混合制成的软材紧握成团，过筛、干燥，再过筛、烘干，加入山梨糖醇、润滑剂硬脂酸镁，混合均匀，用单冲压片机压片，按生产规格进行包装。
2.权利要求1所述的一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，其特征在于：
将15-25重量份虫草用中药粉碎机粉碎，过80-100目筛，在40-50℃的烘箱中烘干，得到虫草粉，匀分成两份，待用；
水热浸提法提取虫草素：
向一份虫草粉中1:15-20加入蒸馏水，充分搅拌均匀，置于55-60℃水浴中，浸提2-3次，每次5-6h，离心，取上层清液，得到含虫草素的滤液； 虫草剩余物直接酶解：
向上述离心后的虫草剩余物中1:10-15加入蒸馏水，用NaOH调溶液pH为10-12，加入碱性蛋白酶，在50-60℃下恒温酶解8-12h后，置于沸水浴中灭酶10-20min，抽滤，得到含虫草多肽的滤液；
（2）超声法提取虫草多糖：
向（1）中所得另一份虫草粉中1:30-40加入蒸馏水，混匀浸泡，在50-55℃下超声提取40-50min，离心，将上清液浓缩、冷却，边搅拌边加入乙醇，于4-6℃静置过夜，离心、沉淀用乙醚、丙酮洗涤3-5次后，放入60-70℃干燥箱中烘干至恒重，得到虫草多糖；将其与黄伞多糖3-2:1混合待用；
（3）将7-13重量份阿胶用粉碎机粉碎，过80-100目筛，得到可直接入药的阿胶细粉；
将6-8重量份黄连、3-4重量份黄芩、4-5重量份白芍混合，1:15-20加入蒸馏水，密封放置，浸泡1-2h，加热至70-80℃回流提取1-2h，过滤，将滤液浓缩至相对密度为1.2-1.3的清膏，在75-85℃下减压干燥至恒重，冷却，粉碎成细粉，与阿胶细粉混合待用；
（4）复方虫草人参阿胶片的制备：
将5-10重量份枸杞子、10-15重量份茯苓、3-5重量份陈皮、3-4重量份益智仁混合，研磨粉碎，过80-100目筛后，与2-4重量份甘草浸膏、2-3重量份肉桂粉、2-4重量份怀山药粉、1-2重量份人参粉及(1)、(2)、(3)中所得物料混合，加入1-2重量份麦芽糊精、2-4重量份食用葡萄糖，混合均匀，缓慢加入粘合剂食用酒精，边滴加边搅拌，制成软硬适中的材料；
将混合制成的软材紧握成团，过18-20目筛，于65-75℃干燥30-40min，过18-20目筛，再置于65-75℃烘箱内烘干20-30min，加入1-2重量份山梨糖醇、0.5-1重量份润滑剂硬脂酸镁，混合均匀，用单冲压片机压片，按生产规格进行包装。
3.权利要求2所述的一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，其特征在于，步骤（1）中所述虫草为广东虫草子实体，离心为3000-4000rpm处理10-20min，NaOH浓度为1-2%，碱性蛋白酶的用量为8000-10000U/g。
4.权利要求2所述的一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，其特征在于，步骤（2）中所述乙醇浓度为90-95%，离心为6000-7000rpm处理5-10min。
5.权利要求2所述的一种能补气血、抗氧化、美容养颜的复方虫草人参阿胶片的制备方法，其特征在于，步骤（4）中所述干燥后物料含水量为3-5%，每片重0.4-0.5g。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108576813A (zh) * | 2018-04-28 | 2018-09-28 | 中国农业科学院特产研究所 | 美容养颜即食人参及其加工方法 |
| CN112336842A (zh) * | 2019-08-09 | 2021-02-09 | 南京科宁检测科技有限公司 | 用于补气、养颜的复方人参阿胶片的制备方法 |
| CN114480015A (zh) * | 2021-12-31 | 2022-05-13 | 安徽全康药业有限公司 | 一种利用超临界co2高效萃取紫苏籽油的工艺 |
| CN114949077A (zh) * | 2021-12-17 | 2022-08-30 | 江苏食品药品职业技术学院 | 一种具有抗氧化功效的北冬虫夏草多糖膏及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105349606A (zh) * | 2015-12-16 | 2016-02-24 | 黑龙江众生生物工程有限公司 | 一种联合酶法对蛹虫草多肽的提取方法 |
| CN106615477A (zh) * | 2017-01-22 | 2017-05-10 | 新乡市人分九种健康管理有限公司 | 一种具有温肾补气功能的复方代用茶及其制备方法 |
-
2017
- 2017-08-02 CN CN201710652476.7A patent/CN107260819A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105349606A (zh) * | 2015-12-16 | 2016-02-24 | 黑龙江众生生物工程有限公司 | 一种联合酶法对蛹虫草多肽的提取方法 |
| CN106615477A (zh) * | 2017-01-22 | 2017-05-10 | 新乡市人分九种健康管理有限公司 | 一种具有温肾补气功能的复方代用茶及其制备方法 |
Non-Patent Citations (3)
| Title |
|---|
| 刘畅等: "黄连阿胶汤现代临床应用概况", 《医药前沿》 * |
| 林连男等: "蛹虫草与黄伞复合多糖抗氧化活性研究", 《安徽农业科学》 * |
| 漆伟等: "冬虫夏草药理学作用的研究进展", 《环球中医药》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108576813A (zh) * | 2018-04-28 | 2018-09-28 | 中国农业科学院特产研究所 | 美容养颜即食人参及其加工方法 |
| CN112336842A (zh) * | 2019-08-09 | 2021-02-09 | 南京科宁检测科技有限公司 | 用于补气、养颜的复方人参阿胶片的制备方法 |
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