CN107216312A - 一种具有突变型idh抑制活性的化合物、其制备方法及用途 - Google Patents
一种具有突变型idh抑制活性的化合物、其制备方法及用途 Download PDFInfo
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- CN107216312A CN107216312A CN201610165095.1A CN201610165095A CN107216312A CN 107216312 A CN107216312 A CN 107216312A CN 201610165095 A CN201610165095 A CN 201610165095A CN 107216312 A CN107216312 A CN 107216312A
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- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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- 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 150000003892 tartrate salts Chemical class 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
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- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
细胞株名称 | 肿瘤细胞类型 |
HT1080 | 人纤维肉瘤细胞 |
MCF-7 | 人乳腺癌细胞 |
T47D | 人乳腺癌细胞株 |
ZR-75 | 人乳腺癌细胞株 |
MAD-MB-468 | 人乳腺癌细胞株 |
Claims (10)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610165095.1A CN107216312B (zh) | 2016-03-22 | 2016-03-22 | 一种具有突变型idh抑制活性的化合物、其制备方法及用途 |
KR1020187030355A KR102245434B1 (ko) | 2016-03-22 | 2017-03-21 | 돌연변이형 idh 억제 활성을 지닌 화합물, 이의 제조 방법 및 용도 |
US16/087,556 US10682352B2 (en) | 2016-03-22 | 2017-03-21 | Compound having mutant IDH inhibitory activity, preparation method and use thereof |
CA3018602A CA3018602C (en) | 2016-03-22 | 2017-03-21 | Pyrimidin-4-yl imidazolidine-2-one derivatives and compositions having mutant idh inhibitory activity, preparation method and use thereof |
EA201892098A EA037974B1 (ru) | 2016-03-22 | 2017-03-21 | Соединение, имеющее мутантную idh ингибирующую активность, способ его получения и применения |
AU2017239295A AU2017239295B2 (en) | 2016-03-22 | 2017-03-21 | Compound having mutant IDH inhibitory activity, preparation method and use thereof |
ES17769410T ES2870910T3 (es) | 2016-03-22 | 2017-03-21 | Derivados de ((4-(2-oxoimidazolidin-1-il)pirimidin-2-il)amina como inhibidores de IDH mutante para tratar el cáncer |
PCT/CN2017/077467 WO2017162133A1 (zh) | 2016-03-22 | 2017-03-21 | 一种具有突变型idh抑制活性的化合物、其制备方法及用途 |
JP2019500718A JP6718553B2 (ja) | 2016-03-22 | 2017-03-21 | 突然変異型idh抑制活性を有する化合物、その製造方法および使用 |
EP17769410.6A EP3434674B1 (en) | 2016-03-22 | 2017-03-21 | ((4-(2-oxoimidazolidine-1-yl)pyrimidin-2-yl)amine derivatives as mutant idh inhibitors for treating cancer |
MX2018011592A MX2018011592A (es) | 2016-03-22 | 2017-03-21 | Compuesto que tiene actividad inhibitoria de idh mutante, metodo de preparacion y usos del mismo. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610165095.1A CN107216312B (zh) | 2016-03-22 | 2016-03-22 | 一种具有突变型idh抑制活性的化合物、其制备方法及用途 |
Publications (2)
Publication Number | Publication Date |
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CN107216312A true CN107216312A (zh) | 2017-09-29 |
CN107216312B CN107216312B (zh) | 2023-08-01 |
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CN201610165095.1A Active CN107216312B (zh) | 2016-03-22 | 2016-03-22 | 一种具有突变型idh抑制活性的化合物、其制备方法及用途 |
Country Status (11)
Country | Link |
---|---|
US (1) | US10682352B2 (zh) |
EP (1) | EP3434674B1 (zh) |
JP (1) | JP6718553B2 (zh) |
KR (1) | KR102245434B1 (zh) |
CN (1) | CN107216312B (zh) |
AU (1) | AU2017239295B2 (zh) |
CA (1) | CA3018602C (zh) |
EA (1) | EA037974B1 (zh) |
ES (1) | ES2870910T3 (zh) |
MX (1) | MX2018011592A (zh) |
WO (1) | WO2017162133A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020216071A1 (zh) * | 2019-04-23 | 2020-10-29 | 上海仕谱生物科技有限公司 | 二聚或多聚体形式的突变型idh抑制剂 |
CN112262145A (zh) * | 2018-04-26 | 2021-01-22 | 上海奕拓医药科技有限责任公司 | 2-氨基嘧啶啶衍生物及其制备方法和用途 |
CN112375069A (zh) * | 2020-11-20 | 2021-02-19 | 湖北民族大学 | 一种4-脲基嘧啶类化合物及其用途 |
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GB201814151D0 (en) | 2018-08-31 | 2018-10-17 | Ucl Business Plc | Compounds |
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- 2016-03-22 CN CN201610165095.1A patent/CN107216312B/zh active Active
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2017
- 2017-03-21 CA CA3018602A patent/CA3018602C/en active Active
- 2017-03-21 US US16/087,556 patent/US10682352B2/en active Active
- 2017-03-21 ES ES17769410T patent/ES2870910T3/es active Active
- 2017-03-21 MX MX2018011592A patent/MX2018011592A/es unknown
- 2017-03-21 EA EA201892098A patent/EA037974B1/ru unknown
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- 2017-03-21 KR KR1020187030355A patent/KR102245434B1/ko active IP Right Grant
- 2017-03-21 JP JP2019500718A patent/JP6718553B2/ja active Active
- 2017-03-21 WO PCT/CN2017/077467 patent/WO2017162133A1/zh active Application Filing
- 2017-03-21 AU AU2017239295A patent/AU2017239295B2/en not_active Ceased
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CN112262145A (zh) * | 2018-04-26 | 2021-01-22 | 上海奕拓医药科技有限责任公司 | 2-氨基嘧啶啶衍生物及其制备方法和用途 |
WO2020216071A1 (zh) * | 2019-04-23 | 2020-10-29 | 上海仕谱生物科技有限公司 | 二聚或多聚体形式的突变型idh抑制剂 |
CN112375069A (zh) * | 2020-11-20 | 2021-02-19 | 湖北民族大学 | 一种4-脲基嘧啶类化合物及其用途 |
CN112375069B (zh) * | 2020-11-20 | 2022-09-13 | 湖北民族大学 | 一种4-脲基嘧啶类化合物及其用途 |
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EP3434674A1 (en) | 2019-01-30 |
WO2017162133A1 (zh) | 2017-09-28 |
JP2019510819A (ja) | 2019-04-18 |
EP3434674B1 (en) | 2021-02-24 |
CA3018602C (en) | 2021-06-22 |
CA3018602A1 (en) | 2017-09-28 |
JP6718553B2 (ja) | 2020-07-08 |
AU2017239295B2 (en) | 2020-01-02 |
EP3434674A4 (en) | 2019-11-27 |
AU2017239295A1 (en) | 2018-10-18 |
MX2018011592A (es) | 2019-06-24 |
ES2870910T3 (es) | 2021-10-28 |
CN107216312B (zh) | 2023-08-01 |
US20190111056A1 (en) | 2019-04-18 |
EA201892098A1 (ru) | 2019-07-31 |
KR20180132721A (ko) | 2018-12-12 |
KR102245434B1 (ko) | 2021-04-29 |
US10682352B2 (en) | 2020-06-16 |
EA037974B1 (ru) | 2021-06-18 |
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