CN107208099B - 共表达疫苗和共刺激分子的载体 - Google Patents
共表达疫苗和共刺激分子的载体 Download PDFInfo
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- CN107208099B CN107208099B CN201680009177.5A CN201680009177A CN107208099B CN 107208099 B CN107208099 B CN 107208099B CN 201680009177 A CN201680009177 A CN 201680009177A CN 107208099 B CN107208099 B CN 107208099B
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562113153P | 2015-02-06 | 2015-02-06 | |
| US62/113,153 | 2015-02-06 | ||
| US201562174942P | 2015-06-12 | 2015-06-12 | |
| US62/174,942 | 2015-06-12 | ||
| PCT/US2016/016682 WO2016127015A1 (en) | 2015-02-06 | 2016-02-05 | Vector co-expressing vaccine and costimulatory molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107208099A CN107208099A (zh) | 2017-09-26 |
| CN107208099B true CN107208099B (zh) | 2022-05-13 |
Family
ID=56564722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680009177.5A Expired - Fee Related CN107208099B (zh) | 2015-02-06 | 2016-02-05 | 共表达疫苗和共刺激分子的载体 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10046047B2 (enExample) |
| EP (1) | EP3253876B1 (enExample) |
| JP (1) | JP6744318B2 (enExample) |
| KR (1) | KR20170109582A (enExample) |
| CN (1) | CN107208099B (enExample) |
| AU (1) | AU2016215175B2 (enExample) |
| BR (1) | BR112017016681A2 (enExample) |
| CA (1) | CA2975191C (enExample) |
| DK (1) | DK3253876T3 (enExample) |
| ES (1) | ES2845727T3 (enExample) |
| IL (1) | IL253423B (enExample) |
| MX (1) | MX384422B (enExample) |
| RU (1) | RU2714157C2 (enExample) |
| SG (1) | SG11201705844SA (enExample) |
| WO (1) | WO2016127015A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6744318B2 (ja) * | 2015-02-06 | 2020-08-26 | ヒート バイオロジクス,インコーポレイテッド | ワクチンおよび共刺激分子を共発現するベクター |
| CN107708725A (zh) * | 2015-04-02 | 2018-02-16 | 坎库雷有限公司 | 用于引发免疫应答的剂和组合物 |
| RU2766200C1 (ru) | 2015-10-01 | 2022-02-09 | Хит Байолоджикс, Инк. | Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков |
| KR20190059304A (ko) * | 2016-09-26 | 2019-05-30 | 어드밴테이진, 인크. | Tim-3 상승을 치료하는 방법 |
| CA3040123A1 (en) | 2016-10-11 | 2018-04-19 | University Of Miami | Vectors and vaccine cells for immunity against zika virus |
| IL268346B2 (en) | 2017-02-06 | 2024-08-01 | Orionis Biosciences BV | Targeted chimeric proteins and uses thereof |
| KR102745835B1 (ko) | 2017-02-27 | 2024-12-24 | 샤턱 랩스 인코포레이티드 | Tigit- 및 light-기반 키메라 단백질 |
| CN118184797A (zh) * | 2017-02-27 | 2024-06-14 | 沙塔克实验室有限公司 | 基于vsig8的嵌合蛋白 |
| CA3054132A1 (en) | 2017-02-27 | 2018-08-30 | Shattuck Labs, Inc. | Csf1r-based chimeric proteins |
| WO2018187260A1 (en) * | 2017-04-04 | 2018-10-11 | Heat Biologics, Inc. | Intratumoral vaccination |
| EP3717003A4 (en) * | 2017-11-27 | 2022-02-16 | Heat Biologics, Inc. | CANCER THERAPY BASED ON NANOPARTICLES |
| CA3083600A1 (en) * | 2017-12-04 | 2019-06-13 | Heat Biologics, Inc. | Production of cell-based vaccines |
| EP3833391A4 (en) | 2018-08-08 | 2022-08-10 | Orionis Biosciences, Inc. | CHIMERIC PROTEINS TARGETED AT SIRP1alpha AND THEIR USES |
| CN112888706A (zh) * | 2018-08-29 | 2021-06-01 | 沙塔克实验室有限公司 | 包含基于tim-3的嵌合蛋白的组合疗法 |
| EP3844176A4 (en) * | 2018-08-29 | 2022-10-12 | Shattuck Labs, Inc. | COMBINATION THERAPIES WITH SIRP-ALPHA-BASED CHIMERA PROTEINS |
| US10780121B2 (en) | 2018-08-29 | 2020-09-22 | Shattuck Labs, Inc. | FLT3L-based chimeric proteins |
| US20210346486A1 (en) * | 2018-10-01 | 2021-11-11 | Heat Biologics, Inc. | Combination cell-based therapies |
| WO2020106621A1 (en) * | 2018-11-19 | 2020-05-28 | Board Of Regents, The University Of Texas System | A modular, polycistronic vector for car and tcr transduction |
| AU2020340372A1 (en) * | 2019-08-30 | 2022-03-10 | Pelican Therapeutics, Inc. | Methods of treating cancer using TNFRSF25 antibodies |
| WO2021178416A1 (en) * | 2020-03-02 | 2021-09-10 | Heat Biologics, Inc. | Immune-mediated coronavirus treatments |
| KR20240099343A (ko) * | 2021-10-26 | 2024-06-28 | 나비큐어 바이오파마슈티컬스 리미티드 | 암 및 감염병에 대한 병용 요법 |
| WO2025227519A1 (zh) * | 2024-04-29 | 2025-11-06 | 北京臻知医学科技有限责任公司 | 一种肿瘤疫苗及其应用 |
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| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US5217891A (en) | 1987-07-28 | 1993-06-08 | Chiron Corporation | DNA constructs containing a kluyveromyces α factor leader sequence for directing secretion of heterologous polypeptides |
| WO1989012455A1 (en) | 1988-06-15 | 1989-12-28 | Whitehead Institute For Biomedical Research | Stress proteins and uses therefor |
| WO1990002564A1 (en) | 1988-09-12 | 1990-03-22 | Codon | Vaccine diagnostic employing proteins homologous to heat shock proteins of trypanosoma cruzi |
| US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| JPH04503309A (ja) | 1989-07-28 | 1992-06-18 | アメリカ合衆国 | 効果的な方向性遺伝子クローニング系 |
| GB9007194D0 (en) | 1990-03-30 | 1990-05-30 | Wellcome Found | Live vaccines |
| US5348945A (en) | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
| US5188964A (en) | 1990-04-12 | 1993-02-23 | Board Of Regents, The University Of Texas System | Method and kit for the prognostication of breast cancer patient via heat shock/stress protein determination |
| GB9016315D0 (en) | 1990-07-25 | 1990-09-12 | Burnie James P | Medicaments |
| JPH06501479A (ja) | 1990-11-08 | 1994-02-17 | スタンフオード・ルツク・リミテツド | 抗原担体 |
| GB9024320D0 (en) | 1990-11-08 | 1990-12-19 | Univ London | Treatment of uveitis |
| GB2251186A (en) | 1990-12-04 | 1992-07-01 | Randall Neal Gatz | Polypeptide for use in treatment of autoimmune disease |
| US5177942A (en) | 1991-08-15 | 1993-01-12 | The Toro Company | Mower deck with improved belt drive arrangement |
| GB9200949D0 (en) | 1992-01-17 | 1992-03-11 | Medical Res Council | Diagnostic peptides |
| FR2688227A1 (fr) | 1992-03-04 | 1993-09-10 | Inst Nat Sante Rech Med | Proteines formant des complexes avec des chaperones et leurs ligands, leurs fragments, leur obtention et leurs applications biologiques. |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| HUT70972A (en) | 1992-03-09 | 1995-11-28 | Ist Naz Stud Cura Dei Tumori | Protein compound capable of inhibiting tumoral growth |
| CA2118015A1 (en) | 1992-04-14 | 1993-10-28 | Jeffrey R. Marks | Method of detecting tumors containing complexes of p53 and hsp70 |
| EP0745121B1 (en) | 1992-05-14 | 2007-06-20 | Baylor College Of Medicine | Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| WO1994003599A1 (fr) | 1992-08-04 | 1994-02-17 | Sagami Chemical Research Center | ADNc HUMAIN ET PROTEINE POUR LAQUELLE CODE CET ADNc |
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