CN107207566B - 稳定的肽缀合抗坏血酸衍生物、用于制备其的方法和包含其的化妆品组合物 - Google Patents
稳定的肽缀合抗坏血酸衍生物、用于制备其的方法和包含其的化妆品组合物 Download PDFInfo
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- CN107207566B CN107207566B CN201580074463.5A CN201580074463A CN107207566B CN 107207566 B CN107207566 B CN 107207566B CN 201580074463 A CN201580074463 A CN 201580074463A CN 107207566 B CN107207566 B CN 107207566B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140167350 | 2014-11-27 | ||
| KR10-2014-0167350 | 2014-11-27 | ||
| PCT/KR2015/011218 WO2016085127A2 (ko) | 2014-11-27 | 2015-10-22 | 펩타이드가 결합된 안정한 아스코르빈산 유도체, 그의 제조방법 및 그를 포함하는 화장료 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107207566A CN107207566A (zh) | 2017-09-26 |
| CN107207566B true CN107207566B (zh) | 2021-01-22 |
Family
ID=56075108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580074463.5A Active CN107207566B (zh) | 2014-11-27 | 2015-10-22 | 稳定的肽缀合抗坏血酸衍生物、用于制备其的方法和包含其的化妆品组合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10239902B2 (https=) |
| EP (1) | EP3225620B1 (https=) |
| JP (1) | JP6500105B2 (https=) |
| KR (1) | KR101652204B1 (https=) |
| CN (1) | CN107207566B (https=) |
| ES (1) | ES2767412T3 (https=) |
| SG (1) | SG11201704321TA (https=) |
| WO (1) | WO2016085127A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018005762A2 (en) * | 2016-06-29 | 2018-01-04 | Orasis Medical, Inc. | Ascorbic acid-amino acid conjugates and their use in regulation of fluid outflow |
| JP6875704B2 (ja) * | 2018-04-13 | 2021-05-26 | マイクロアルジェコーポレーション株式会社 | メラニン生成抑制用組成物、美白用組成物、及び発現抑制用組成物 |
| KR102130701B1 (ko) * | 2018-09-27 | 2020-07-06 | 주식회사 차메디텍 | 비타민 c가 결합된 펩타이드 유도체 및 이를 포함하는 조성물 |
| KR102222697B1 (ko) | 2019-05-02 | 2021-03-04 | (주)리즈케이 | 아스코르빈산 함유 화장료 조성물 및 이를 포함하는 화장품 |
| KR102740870B1 (ko) * | 2020-08-05 | 2024-12-12 | 주식회사 레미바이오 | 아스코르브산 유도체 및 이를 포함하는 조성물 |
| CN115260170B (zh) * | 2021-04-30 | 2024-05-28 | 禾美生物科技(浙江)有限公司 | 抗坏血酸多肽衍生物及其制备方法和应用 |
| KR102726678B1 (ko) | 2022-04-20 | 2024-11-07 | 주식회사 바른바름 | 4-알킬레졸시놀을 포함하는 고체지질 나노입자, 이를 포함하는 화장료 조성물 및 화장품 |
| KR102576447B1 (ko) * | 2022-11-14 | 2023-09-08 | 주식회사 차메디텍 | 열 안정성이 증대된 비타민 c-펩타이드 유도체 및 이를 포함하는 콜라겐 형성용, 미백용 및/또는 항산화용 조성물 |
| CN116035923B (zh) * | 2022-11-19 | 2024-12-20 | 陕西佰鸿合成生物科技有限公司 | 一种含神经酰胺&rgd多肽的纳米乳液及其制备方法和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409693A (en) * | 1989-10-12 | 1995-04-25 | Perricone; Nicholas V. | Method for treating and preventing sunburn and sunburn damage to the skin |
| JP2772712B2 (ja) * | 1990-11-15 | 1998-07-09 | 花王株式会社 | アスコルビン酸誘導体及びその製造法 |
| DE19824983C2 (de) * | 1997-06-04 | 2001-06-28 | Pacific Corp | 2-(3-Aminopropylphosphorsäure)-L-ascorbat, Verfahren zu seiner Herstellung und dieses enthaltende kosmetische Zubereitung zur Aufhellung der Haut |
| JP2001270816A (ja) * | 2000-03-23 | 2001-10-02 | Ichimaru Pharcos Co Ltd | 化粧料組成物 |
| JP2004529884A (ja) * | 2001-02-26 | 2004-09-30 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | 金属放射性医薬のためのアスコルビン酸類似体 |
| JPWO2004028484A1 (ja) * | 2002-09-24 | 2006-01-19 | 株式会社坂本バイオ | メラニン生成抑制剤、美白剤、メラニン生成抑制用組成物及び美白用組成物 |
| KR100459679B1 (ko) * | 2003-04-30 | 2004-12-03 | 주식회사 펩트론 | 펩타이드가 결합된 비타민 씨 유도체, 이의 제조방법 및이를 포함하는 조성물 |
| WO2007094030A1 (ja) * | 2006-02-13 | 2007-08-23 | Sakamoto Bio Co., Ltd. | 美白剤 |
| KR100691540B1 (ko) * | 2006-06-22 | 2007-03-12 | 주식회사 펩트론 | 펩타이드가 결합된 안정화된 비타민 c 유도체, 이의제조방법 및 이를 함유하는 조성물 |
| JP5255775B2 (ja) * | 2007-03-15 | 2013-08-07 | ピアス株式会社 | 水性ゲル、皮膚外用剤および化粧料 |
| KR101413939B1 (ko) * | 2007-10-20 | 2014-06-30 | 재단법인서울대학교산학협력재단 | 펩타이드가 결합된 아스코르빈산 유도체 |
| US9408797B2 (en) * | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
-
2015
- 2015-10-22 KR KR1020150147473A patent/KR101652204B1/ko active Active
- 2015-10-22 EP EP15864076.3A patent/EP3225620B1/en active Active
- 2015-10-22 WO PCT/KR2015/011218 patent/WO2016085127A2/ko not_active Ceased
- 2015-10-22 SG SG11201704321TA patent/SG11201704321TA/en unknown
- 2015-10-22 ES ES15864076T patent/ES2767412T3/es active Active
- 2015-10-22 CN CN201580074463.5A patent/CN107207566B/zh active Active
- 2015-10-22 JP JP2017527922A patent/JP6500105B2/ja active Active
-
2017
- 2017-05-26 US US15/606,628 patent/US10239902B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3225620B1 (en) | 2019-11-20 |
| EP3225620A4 (en) | 2018-11-07 |
| US20170258931A1 (en) | 2017-09-14 |
| US10239902B2 (en) | 2019-03-26 |
| SG11201704321TA (en) | 2017-06-29 |
| KR101652204B1 (ko) | 2016-08-29 |
| WO2016085127A2 (ko) | 2016-06-02 |
| ES2767412T3 (es) | 2020-06-17 |
| JP6500105B2 (ja) | 2019-04-10 |
| CN107207566A (zh) | 2017-09-26 |
| KR20160063976A (ko) | 2016-06-07 |
| WO2016085127A3 (ko) | 2016-10-06 |
| JP2018509376A (ja) | 2018-04-05 |
| EP3225620A2 (en) | 2017-10-04 |
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