CN1071332C - 促肠动的苯甲酰胺 - Google Patents

促肠动的苯甲酰胺 Download PDF

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Publication number
CN1071332C
CN1071332C CN95196347A CN95196347A CN1071332C CN 1071332 C CN1071332 C CN 1071332C CN 95196347 A CN95196347 A CN 95196347A CN 95196347 A CN95196347 A CN 95196347A CN 1071332 C CN1071332 C CN 1071332C
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CN
China
Prior art keywords
compound
arbitrary
described compound
medicine
purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN95196347A
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English (en)
Chinese (zh)
Other versions
CN1164233A (zh
Inventor
G·H·P·范德利
J·P·R·M·A·博斯曼斯
J·A·J·舒尔科斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8217407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1071332(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CN1164233A publication Critical patent/CN1164233A/zh
Application granted granted Critical
Publication of CN1071332C publication Critical patent/CN1071332C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN95196347A 1994-11-24 1995-11-16 促肠动的苯甲酰胺 Expired - Lifetime CN1071332C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP942023421.6 1994-11-24
EP94203421 1994-11-24

Publications (2)

Publication Number Publication Date
CN1164233A CN1164233A (zh) 1997-11-05
CN1071332C true CN1071332C (zh) 2001-09-19

Family

ID=8217407

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95196347A Expired - Lifetime CN1071332C (zh) 1994-11-24 1995-11-16 促肠动的苯甲酰胺

Country Status (40)

Country Link
US (3) US5854260A (enExample)
EP (1) EP0807110B1 (enExample)
JP (1) JP3046076B2 (enExample)
KR (1) KR100233489B1 (enExample)
CN (1) CN1071332C (enExample)
AP (1) AP777A (enExample)
AR (1) AR001769A1 (enExample)
AT (1) ATE217306T1 (enExample)
AU (1) AU704043B2 (enExample)
BG (1) BG63710B1 (enExample)
BR (1) BRPI9509819B8 (enExample)
CA (1) CA2205573C (enExample)
CY (2) CY2296B1 (enExample)
CZ (1) CZ292847B6 (enExample)
DE (2) DE69526679T2 (enExample)
DK (1) DK0807110T3 (enExample)
EE (1) EE03313B1 (enExample)
ES (1) ES2177671T3 (enExample)
FI (1) FI120147B (enExample)
FR (1) FR10C0001I2 (enExample)
HR (1) HRP950571B1 (enExample)
HU (1) HU226560B1 (enExample)
IL (1) IL116101A (enExample)
LU (1) LU91644I2 (enExample)
MY (1) MY112944A (enExample)
NL (1) NL300435I1 (enExample)
NO (3) NO312726B1 (enExample)
NZ (1) NZ297753A (enExample)
OA (1) OA10422A (enExample)
PL (1) PL183713B1 (enExample)
PT (1) PT807110E (enExample)
RO (1) RO116279B1 (enExample)
RU (1) RU2154643C2 (enExample)
SI (1) SI0807110T1 (enExample)
SK (1) SK283499B6 (enExample)
TR (1) TR199501483A2 (enExample)
TW (1) TW490465B (enExample)
UA (1) UA59334C2 (enExample)
WO (1) WO1996016060A1 (enExample)
ZA (1) ZA959996B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727351A (zh) * 2017-04-19 2018-11-02 鲁南制药集团股份有限公司 一种普芦卡必利的精制方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
TW548103B (en) * 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
AU753706B2 (en) * 1998-05-14 2002-10-24 Egis Gyogyszergyar Rt. Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
CA2352278A1 (en) * 1998-11-23 2000-06-02 Janssen Pharmaceutica, N.V. Use of prucalopride for the manufacture of a medicament for the treatment of dyspepsia
TW592709B (en) * 1999-04-29 2004-06-21 Janssen Pharmaceutica Nv Prucalopride oral solution
CN1288730A (zh) * 1999-09-07 2001-03-28 麦克内尔-Ppc股份有限公司 轻泻组合物
AU2003206722B2 (en) * 2002-01-16 2008-01-24 Mercury Pharma Group Limited Prucalopride-N-oxide
JP5797655B2 (ja) * 2009-09-18 2015-10-21 アドラー・コーポレーション 消化管障害のためのオピオイド受容体アンタゴニストの使用
GB201103397D0 (enExample) 2011-02-28 2011-04-13 Shire Movetis N V
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
JP2014525927A (ja) 2011-08-18 2014-10-02 シャイアー アーゲー 治療法に使用される５−ｈｔ４受容体アゴニスト及びｐｄｅ４阻害剤の組合せ
WO2017137910A1 (en) * 2016-02-11 2017-08-17 Symed Labs Limited Processes for the preparation of highly pure prucalopride succinate and its intermediates
CN119700664B (zh) * 2025-02-28 2025-06-20 山东新时代药业有限公司 含有活性成分琥珀酸普芦卡必利的注射液及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1045781A (zh) * 1989-03-22 1990-10-03 詹森药业有限公司 N-(3-羟基-4-哌啶基)(二氢苯并呋喃，二氢-2h-苯并吡喃或二氢苯并二英)甲酰胺衍生物
CN1054598A (zh) * 1990-03-06 1991-09-18 詹森药业有限公司 甲酰胺衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593504B1 (fr) * 1986-01-30 1988-12-09 Ile De France Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1045781A (zh) * 1989-03-22 1990-10-03 詹森药业有限公司 N-(3-羟基-4-哌啶基)(二氢苯并呋喃，二氢-2h-苯并吡喃或二氢苯并二英)甲酰胺衍生物
CN1054598A (zh) * 1990-03-06 1991-09-18 詹森药业有限公司 甲酰胺衍生物的制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727351A (zh) * 2017-04-19 2018-11-02 鲁南制药集团股份有限公司 一种普芦卡必利的精制方法
CN108727351B (zh) * 2017-04-19 2021-08-31 鲁南制药集团股份有限公司 一种普芦卡必利的精制方法

Also Published As

Publication number Publication date
PL320297A1 (en) 1997-09-15
TR199501483A2 (tr) 1996-07-21
SK283499B6 (sk) 2003-08-05
HU226560B1 (en) 2009-04-28
JP3046076B2 (ja) 2000-05-29
EP0807110B1 (en) 2002-05-08
UA59334C2 (uk) 2003-09-15
CY2010001I2 (el) 2010-07-28
CY2296B1 (en) 2003-07-04
NO2019044I1 (no) 2019-12-11
JPH09512832A (ja) 1997-12-22
CA2205573C (en) 2006-05-09
US5854260A (en) 1998-12-29
BG101605A (bg) 1998-02-27
AP777A (en) 1999-10-28
RO116279B1 (ro) 2000-12-29
SK65297A3 (en) 1997-10-08
CN1164233A (zh) 1997-11-05
HUT77375A (hu) 1998-04-28
NO972143D0 (no) 1997-05-09
HRP950571A2 (en) 1997-08-31
TW490465B (en) 2002-06-11
ES2177671T3 (es) 2002-12-16
HRP950571B1 (en) 2001-12-31
DE122010000002I1 (de) 2011-12-01
AP9700992A0 (en) 1997-07-31
IL116101A0 (en) 1996-01-31
DE69526679D1 (de) 2002-06-13
KR100233489B1 (ko) 1999-12-01
SI0807110T1 (en) 2002-08-31
DE69526679T2 (de) 2002-12-05
BRPI9509819B1 (pt) 2018-05-15
CA2205573A1 (en) 1996-05-30
NZ297753A (en) 1998-05-27
EE03313B1 (et) 2000-12-15
FR10C0001I2 (fr) 2011-04-01
CY2010001I1 (el) 2010-07-28
NL300435I1 (nl) 2010-04-01
IL116101A (en) 1999-08-17
ZA959996B (en) 1997-05-23
BRPI9509819B8 (pt) 2021-07-06
BG63710B1 (bg) 2002-10-31
LU91644I2 (en) 2010-03-29
AU4299296A (en) 1996-06-17
AU704043B2 (en) 1999-04-15
AR001769A1 (es) 1997-12-10
NO2010003I1 (no) 2010-03-05
NO312726B1 (no) 2002-06-24
FI972203A0 (fi) 1997-05-23
DK0807110T3 (da) 2002-09-02
FI972203L (fi) 1997-05-23
NO972143L (no) 1997-05-09
OA10422A (en) 2002-03-19
MY112944A (en) 2001-10-31
FR10C0001I1 (enExample) 2010-02-12
MX9703869A (es) 1997-09-30
ATE217306T1 (de) 2002-05-15
EP0807110A1 (en) 1997-11-19
PL183713B1 (pl) 2002-07-31
BR9509819A (pt) 1997-09-30
US5948794A (en) 1999-09-07
CZ292847B6 (cs) 2003-12-17
WO1996016060A1 (en) 1996-05-30
CZ155597A3 (en) 1997-09-17
FI120147B (fi) 2009-07-15
US6310077B1 (en) 2001-10-30
RU2154643C2 (ru) 2000-08-20
PT807110E (pt) 2002-10-31
NO2010003I2 (no) 2012-08-27

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Granted publication date: 20010919

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