CN107074958A - 用于治疗肿瘤的抗‑pd‑l1组合 - Google Patents

用于治疗肿瘤的抗‑pd‑l1组合 Download PDF

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Publication number
CN107074958A
CN107074958A CN201580036993.0A CN201580036993A CN107074958A CN 107074958 A CN107074958 A CN 107074958A CN 201580036993 A CN201580036993 A CN 201580036993A CN 107074958 A CN107074958 A CN 107074958A
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alkyl
amino
combination
aryl
imidazos
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李立新
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Bo Di Bio Tech Ltd
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Bo Di Bio Tech Ltd
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Priority claimed from CN201410325480.9A external-priority patent/CN105233291A/zh
Priority claimed from CN201410440824.0A external-priority patent/CN105440135A/zh
Application filed by Bo Di Bio Tech Ltd filed Critical Bo Di Bio Tech Ltd
Publication of CN107074958A publication Critical patent/CN107074958A/zh
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    • A61K31/708Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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CN201580036993.0A 2014-07-09 2015-07-08 用于治疗肿瘤的抗‑pd‑l1组合 Pending CN107074958A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201410325480.9A CN105233291A (zh) 2014-07-09 2014-07-09 用于治疗癌症的联合治疗组合物和联合治疗方法
CN2014103254809 2014-07-09
CN201410440824.0A CN105440135A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
CN2014104408240 2014-09-01
PCT/CN2015/083585 WO2016004876A1 (fr) 2014-07-09 2015-07-08 Combinaisons anti-pd-l1 pour le traitement des tumeurs

Publications (1)

Publication Number Publication Date
CN107074958A true CN107074958A (zh) 2017-08-18

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CN201580036993.0A Pending CN107074958A (zh) 2014-07-09 2015-07-08 用于治疗肿瘤的抗‑pd‑l1组合

Country Status (11)

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US (4) US20170114137A1 (fr)
EP (2) EP4001311A1 (fr)
JP (3) JP6760919B2 (fr)
KR (1) KR102462743B1 (fr)
CN (1) CN107074958A (fr)
AU (3) AU2015286043B2 (fr)
CA (1) CA2954446A1 (fr)
DK (1) DK3166976T3 (fr)
ES (1) ES2910446T3 (fr)
TW (2) TWI691335B (fr)
WO (1) WO2016004876A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111757755A (zh) * 2017-12-21 2020-10-09 大日本住友制药株式会社 包含tlr7激动剂的组合药物

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20240240T1 (hr) 2008-12-09 2024-04-26 F. Hoffmann - La Roche Ag Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice
CN103566377A (zh) 2012-07-18 2014-02-12 上海博笛生物科技有限公司 癌症的靶向免疫治疗
AU2015205756A1 (en) 2014-01-10 2016-07-21 Birdie Biopharmaceuticals Inc. Compounds and compositions for treating EGFR expressing tumors
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
JP6588461B2 (ja) 2014-03-31 2019-10-09 ジェネンテック, インコーポレイテッド 抗血管新生剤及びox40結合アゴニストを含む併用療法
EP4001311A1 (fr) 2014-07-09 2022-05-25 Birdie Biopharmaceuticals Inc. Combinaisons anti-pd-l1 pour le traitement des tumeurs
CN112546238A (zh) 2014-09-01 2021-03-26 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
MA42971A (fr) 2015-03-13 2018-08-15 Cytomx Therapeutics Inc Anticorps anti-pdl1, anticorps anti-pld1 activables, et leurs procédés d'utilisation
RS63897B1 (sr) 2015-05-29 2023-02-28 Bristol Myers Squibb Co Antitela protiv ox40 i njihova primena
MX2018000621A (es) 2015-07-13 2018-05-11 Cytomx Therapeutics Inc Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y metodos de uso de los mismos.
WO2017046675A1 (fr) 2015-09-14 2017-03-23 Pfizer Inc. Nouveaux dérivés imidazo [4,5-c] quinoline et imidazo [4,5-c] [1,5] naphthyridine utilisés comme inhibiteurs de lrrk2
KR20180053674A (ko) 2015-10-02 2018-05-23 에프. 호프만-라 로슈 아게 공자극 tnf 수용체에 특이적인 이중특이성 항체
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
CN106943596A (zh) 2016-01-07 2017-07-14 博笛生物科技(北京)有限公司 用于治疗肿瘤的抗-cd20组合
CN106943598A (zh) 2016-01-07 2017-07-14 博笛生物科技(北京)有限公司 用于治疗肿瘤的抗-her2组合
CN106943597A (zh) 2016-01-07 2017-07-14 博笛生物科技(北京)有限公司 用于治疗肿瘤的抗-egfr组合
KR20180134395A (ko) * 2016-04-19 2018-12-18 인네이트 튜머 이뮤니티, 인코포레이티드 Nlrp3 조정제
KR20210010678A (ko) * 2016-06-30 2021-01-27 난트 홀딩스 아이피, 엘엘씨 난트 암 백신
US20190307741A1 (en) * 2016-07-06 2019-10-10 Pierre Fabre Medicament Vinflunine and pd1 and/or pdl1 inhibitor as pharmaceutical combination
CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
WO2018027204A1 (fr) 2016-08-05 2018-02-08 Genentech, Inc. Anticorps multivalents et multiépitopiques ayant une activité agoniste et procédés d'utilisation
JP7374415B2 (ja) * 2016-11-02 2023-11-09 国立大学法人京都大学 Pd-1シグナル阻害剤による疾患治療における有効性判定マーカー
TW201827076A (zh) * 2016-12-12 2018-08-01 美商建南德克公司 使用抗pd-l1抗體及抗雄激素治療癌症之方法
CN108794467A (zh) 2017-04-27 2018-11-13 博笛生物科技有限公司 2-氨基-喹啉衍生物
KR20200016899A (ko) 2017-06-01 2020-02-17 싸이톰스 테라퓨틱스, 인크. 활성화가능 항-pdl1 항체, 및 이의 이용 방법
AU2017419352B2 (en) 2017-06-23 2024-05-30 Birdie Biopharmaceuticals, Inc. Pharmaceutical compositions
KR102328403B1 (ko) * 2017-11-07 2021-11-19 제이 파마 가부시끼가이샤 항pd-1 항체 혹은 항pd-l1 항체 요법의 주효성을 예측하는 방법, 암의 악성도를 평가하는 방법, 및 항pd-1 항체 혹은 항pd-l1 항체 요법의 주효성을 상승시키는 방법
CR20200649A (es) 2018-05-25 2021-05-11 Primmune Therapeutics Inc Agosnistas de tlr7
JP2022501327A (ja) * 2018-09-07 2022-01-06 バーディー バイオファーマシューティカルズ インコーポレイテッド イミダゾキノリン化合物およびその使用
US20220016152A1 (en) * 2018-12-26 2022-01-20 Birdie Biopharmaceuticals, Inc. Immune modulatory combinations and methods for treating cancers
JP2022525594A (ja) 2019-03-15 2022-05-18 ボルト バイオセラピューティクス、インコーポレーテッド Her2を標的とする免疫結合体
BR112022010165A2 (pt) 2019-11-26 2022-08-09 Primmune Therapeutics Inc Agonistas de tlr7
JP2023514727A (ja) 2020-02-21 2023-04-07 シルバーバック セラピューティックス インコーポレイテッド ネクチン-4抗体コンジュゲートおよびその使用
CN116209678A (zh) 2020-07-01 2023-06-02 安尔士制药公司 抗asgr1抗体缀合物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014012479A1 (fr) * 2012-07-18 2014-01-23 Shanghai Birdie Biotech, Inc. Composés pour immunothérapie ciblée

Family Cites Families (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73534A (en) 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
CA1271477A (fr) 1983-11-18 1990-07-10 John F. Gerster 1h-imidazo[4,5-c]quinoleine-4-amines
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
WO1990005144A1 (fr) 1988-11-11 1990-05-17 Medical Research Council Ligands a domaine unique, recepteurs comprenant lesdits ligands, procedes pour leur production, et emploi desdits ligands et recepteurs
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US6399754B1 (en) 1991-12-24 2002-06-04 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5789163A (en) 1990-06-11 1998-08-04 Nexstar Pharmaceuticals, Inc. Enzyme linked oligonucleotide assays (ELONAS)
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US6280932B1 (en) 1990-06-11 2001-08-28 Gilead Sciences, Inc. High affinity nucleic acid ligands to lectins
US5874218A (en) 1990-06-11 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for detecting a target compound in a substance using a nucleic acid ligand
WO1991019813A1 (fr) 1990-06-11 1991-12-26 The University Of Colorado Foundation, Inc. Ligands d'acide nucleique
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5853984A (en) 1990-06-11 1998-12-29 Nexstar Pharmaceuticals, Inc. Use of nucleic acid ligands in flow cytometry
US6716580B2 (en) 1990-06-11 2004-04-06 Somalogic, Inc. Method for the automated generation of nucleic acid ligands
US6001577A (en) 1998-06-08 1999-12-14 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US6465189B1 (en) 1990-06-11 2002-10-15 Gilead Sciences, Inc. Systematic evolution of ligands by exponential enrichment: blended selex
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
US5389640A (en) 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
US5226575A (en) 1991-11-21 1993-07-13 Scott Faust Pneumatic mortar dispenser with flex release
ATE419355T1 (de) 1992-02-06 2009-01-15 Novartis Vaccines & Diagnostic Marker für krebs und biosynthetisches bindeprotein dafür
US6608201B2 (en) 1992-08-28 2003-08-19 3M Innovative Properties Company Process for preparing 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5352784A (en) 1993-07-15 1994-10-04 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US6458539B1 (en) 1993-09-17 2002-10-01 Somalogic, Inc. Photoselection of nucleic acid ligands
US5596091A (en) 1994-03-18 1997-01-21 The Regents Of The University Of California Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
US5482936A (en) 1995-01-12 1996-01-09 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]quinoline amines
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US5843732A (en) 1995-06-06 1998-12-01 Nexstar Pharmaceuticals, Inc. Method and apparatus for determining consensus secondary structures for nucleic acid sequences
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
WO1998008856A2 (fr) 1996-08-30 1998-03-05 Fuerste Jens Peter Selection et evolution speculaires d'acides nucleiques
US5939090A (en) 1996-12-03 1999-08-17 3M Innovative Properties Company Gel formulations for topical drug delivery
US6127533A (en) 1997-02-14 2000-10-03 Isis Pharmaceuticals, Inc. 2'-O-aminooxy-modified oligonucleotides
UA67760C2 (uk) 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US6110929A (en) 1998-07-28 2000-08-29 3M Innovative Properties Company Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
US6403779B1 (en) 1999-01-08 2002-06-11 Isis Pharmaceuticals, Inc. Regioselective synthesis of 2′-O-modified nucleosides
US20030054360A1 (en) 1999-01-19 2003-03-20 Larry Gold Method and apparatus for the automated generation of nucleic acid ligands
US6451810B1 (en) 1999-06-10 2002-09-17 3M Innovative Properties Company Amide substituted imidazoquinolines
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
DK2283866T3 (en) 1999-06-25 2015-05-18 Genentech Inc METHODS OF TREATMENT USING ANTI-ERBB ANTIBODY-MAYTANSINOID CONJUGATES
US6506887B1 (en) 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
US6635677B2 (en) 1999-08-13 2003-10-21 Case Western Reserve University Methoxyamine combinations in the treatment of cancer
US6936704B1 (en) 1999-08-23 2005-08-30 Dana-Farber Cancer Institute, Inc. Nucleic acids encoding costimulatory molecule B7-4
BR0013581A (pt) 1999-08-23 2002-07-02 Dana Faber Cancer Inst Inc Pd-1, um receptor para b7-4, e usos para isto
US6376669B1 (en) 1999-11-05 2002-04-23 3M Innovative Properties Company Dye labeled imidazoquinoline compounds
US6803192B1 (en) 1999-11-30 2004-10-12 Mayo Foundation For Medical Education And Research B7-H1, a novel immunoregulatory molecule
US20050032733A1 (en) 2001-05-18 2005-02-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US20050020525A1 (en) 2002-02-20 2005-01-27 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US6376190B1 (en) 2000-09-22 2002-04-23 Somalogic, Inc. Modified SELEX processes without purified protein
US20060057651A1 (en) 2000-12-08 2006-03-16 Bowdish Katherine S Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
UA74852C2 (en) 2000-12-08 2006-02-15 3M Innovative Properties Co Urea-substituted imidazoquinoline ethers
UA74593C2 (en) 2000-12-08 2006-01-16 3M Innovative Properties Co Substituted imidazopyridines
US20060142202A1 (en) 2000-12-08 2006-06-29 3M Innovative Properties Company Compositions and methods for targeted delivery of immune response modifiers
US6664264B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
EP1383912A4 (fr) 2001-04-02 2007-11-28 Wyeth Corp Le pd-1, recepteur du b7-4, et ses utilisations
US20030175950A1 (en) 2001-05-29 2003-09-18 Mcswiggen James A. RNA interference mediated inhibition of HIV gene expression using short interfering RNA
EP1264603B8 (fr) 2001-06-10 2010-03-03 Noxxon Pharma AG Utilisation de L-polynucleotides pour l'imagerie diagnostique
AU2775402A (en) 2001-06-29 2003-01-02 Medimolecular Pty Ltd Nucleic acid ligands to complex targets
JP2005519990A (ja) 2001-10-12 2005-07-07 ユニバーシティ オブ アイオワ リサーチ ファウンデーション イミダゾキノリン化合物を用いて免疫応答を増強するための方法および産物
JP4488740B2 (ja) 2001-11-13 2010-06-23 ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド 免疫細胞活性化を調節する作用剤およびその使用方法
AU2002343728A1 (en) 2001-11-16 2003-06-10 3M Innovative Properties Company Methods and compositions related to irm compounds and toll-like receptor pathways
BR0214407A (pt) 2001-11-27 2004-10-19 Anadys Pharmaceuticals Inc Compostos, composições farmacêuticas e método de modulação das imunoatividades da citocina
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
US20040092470A1 (en) 2002-06-18 2004-05-13 Leonard Sherry A. Dry powder oligonucleotide formualtion, preparation and its uses
PT2206517T (pt) 2002-07-03 2023-11-07 Tasuku Honjo Composições de imunopotenciação contendo anticorpos anti-pd-l1
EP1413316A1 (fr) 2002-09-27 2004-04-28 Bruno Robert Conjugués bifonctionnels ou protéines de fusions
MXPA05006740A (es) 2002-12-20 2005-10-05 3M Innovative Properties Co Imidazoquinolinas arilo-sustituidas.
ATE514713T1 (de) 2002-12-23 2011-07-15 Wyeth Llc Antikörper gegen pd-1 und ihre verwendung
WO2004062603A2 (fr) 2003-01-09 2004-07-29 Arizeke Pharmaceuticals Inc. Methodes de traitement de maladies pulmonaires
US9259459B2 (en) 2003-01-31 2016-02-16 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
JP2006517974A (ja) 2003-02-13 2006-08-03 スリーエム イノベイティブ プロパティズ カンパニー Irm化合物およびトル様受容体8に関する方法および組成物
ATE465742T1 (de) 2003-09-05 2010-05-15 Anadys Pharmaceuticals Inc Tlr7-liganden zur behandlung von hepatitis c
WO2005079195A2 (fr) 2003-10-03 2005-09-01 3M Innovative Properties Company Pyrazolopyridines et analogues de celles-ci
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
RU2426734C2 (ru) 2003-10-03 2011-08-20 Зм Инновейтив Пропертиз Компани Пиразолопиридины и их аналоги
AU2004280143A1 (en) 2003-10-11 2005-04-21 Tekmira Pharmaceuticals Corporation Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
CN107213469A (zh) 2003-11-06 2017-09-29 西雅图基因公司 能够与配体偶联的单甲基缬氨酸化合物
WO2005067500A2 (fr) 2003-12-30 2005-07-28 3M Innovative Properties Company Amelioration de la reponse immunitaire
ES2563952T3 (es) 2004-03-26 2016-03-16 Sumitomo Dainippon Pharma Co., Ltd. Compuesto de 8-oxoadenina 9-sustituido
JP2008506683A (ja) 2004-07-18 2008-03-06 コーリー ファーマシューティカル グループ, リミテッド 先天免疫応答を誘導するための方法および組成物
AU2005304771A1 (en) 2004-11-09 2006-05-18 University Of Southern California Targeted innate immunity
DK1830876T3 (en) 2004-12-30 2015-07-13 Meda Ab Use of imiquimod for the treatment of cutaneous metastases derived from a mammary cancer tumor
CA2599151A1 (fr) 2005-02-24 2006-08-31 Janssen Pharmaceutica N.V. Nouveaux derives de quinoleine utilises en tant qu'ouvreurs du canal ionique a potassium
KR20080003422A (ko) 2005-04-14 2008-01-07 메르크 파텐트 게엠베하 종양 조직 내의 egfr 유전자의 증가된 복제수에 기초한항-egfr 항체 치료
EP2511299A1 (fr) 2005-04-19 2012-10-17 Seattle Genetics, Inc. Agents de liaison anti-CD70 humanisés et utilisations
US7976852B2 (en) 2005-04-26 2011-07-12 Eisai R&D Management Co., Ltd. Compositions and methods for cancer immunotherapy
JP2008540363A (ja) 2005-05-04 2008-11-20 ノクソン・フアルマ・アクチエンゲゼルシヤフト シュピーゲルマーの新規な使用
DK2439273T3 (da) 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
CA3201163A1 (fr) 2005-07-01 2007-01-11 E. R. Squibb & Sons, L.L.C. Anticorps monoclonaux humains diriges contre un ligand de mort programmee de type 1(pd-l1)
US8871720B2 (en) 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
TWI404537B (zh) 2005-08-19 2013-08-11 Array Biopharma Inc 作為類鐸受體(toll-like receptor)調節劑之8-經取代苯并氮雜呯
TWI382019B (zh) 2005-08-19 2013-01-11 Array Biopharma Inc 作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯
EP1928912A4 (fr) 2005-09-07 2010-02-24 Medimmune Inc Anticorps anti-recepteur eph conjugues a des toxines
ZA200803029B (en) 2005-09-09 2009-02-25 Coley Pharm Group Inc Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
EP1988896A4 (fr) 2006-02-22 2011-07-27 3M Innovative Properties Co Conjugués du modificateur de réponse immune
WO2007103048A2 (fr) 2006-03-01 2007-09-13 Regents Of The University Of Colorado Conjugués de protéine agoniste de tlr (flagelline)/agoniste de cd40/ antigène et d'adn et leur utilisation pour induire un renforcement synergique de l'immunité
US20080031887A1 (en) 2006-06-30 2008-02-07 Joseph Lustgarten Conjugates for inducing targeted immune responses and methods of making and using same
EP2041135A4 (fr) 2006-07-05 2010-12-01 Astrazeneca Ab Dérivés de la 8-oxoadénine agissant comme modulateurs de tlr7
PT2845866T (pt) 2006-10-27 2017-08-09 Genentech Inc Anticorpos e imunoconjugados e utilizações dos mesmos
US20080149123A1 (en) 2006-12-22 2008-06-26 Mckay William D Particulate material dispensing hairbrush with combination bristles
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
TWI422594B (zh) 2007-02-02 2014-01-11 Baylor Res Inst 經由樹狀細胞去唾液酸糖蛋白受體(dc-asgpr)接合抗原呈現細胞之藥劑
SI2510946T1 (sl) 2007-02-07 2015-12-31 The Regents Of The University Of California Konjugati sintetičnih agonistov TLR in njihove uporabe
US8436178B2 (en) 2007-05-08 2013-05-07 Astrazeneca Ab Imidazoquinolines with immuno-modulating properties
ES2616355T3 (es) 2007-06-18 2017-06-12 Merck Sharp & Dohme B.V. Anticuerpos para el receptor humano de muerte programada PD-1
US20090123467A1 (en) 2007-07-31 2009-05-14 The Johns Hopkins University Polypeptide-Nucleic Acid Conjugate for Immunoprophylaxis or Immunotherapy for Neoplastic or Infectious Disorders
EP3492488A1 (fr) 2007-08-22 2019-06-05 The Regents of The University of California Polypeptides de liaison activables et procédés d'identification et utilisation de ceux-ci
PL2644192T3 (pl) 2007-09-28 2017-09-29 Pfizer Inc. Ukierunkowanie na komórki nowotworowe z zastosowaniem nanocząstek
US8062852B2 (en) 2007-10-01 2011-11-22 The Children's Hospital And Regional Medical Center Detection and treatment of autoimmune disorders
WO2009089900A1 (fr) 2008-01-15 2009-07-23 Meda Ab Traitement de maladies du côlon ou prévention du carcinome colorectal au moyen de dérivés d'imidazoquinoline
AU2009207287B2 (en) 2008-01-25 2014-09-11 Gavish-Galilee Bio Applications Ltd Targeting of innate immune response to tumor site
US20090202626A1 (en) 2008-02-07 2009-08-13 Carson Dennis A Treatment of bladder diseases with a tlr7 activator
WO2009114335A2 (fr) 2008-03-12 2009-09-17 Merck & Co., Inc. Protéines de liaison avec pd-1
AR070865A1 (es) 2008-03-18 2010-05-12 Genentech Inc Combinaciones de un conjugado anticuerpo- farmaco anti- her2 y agentes quimioterapeuticos y los metodos de uso
EP2316032A1 (fr) 2008-08-20 2011-05-04 INSERM - Institut National de la Santé et de la Recherche Médicale Procédés permettant de prédire la réponse à un traitement anti-cancer à l'aide d'un agoniste de tlr7 ou d'un agoniste de tlr8
KR101814408B1 (ko) 2008-09-26 2018-01-04 다나-파버 캔서 인스티튜트 인크. 인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도
US8895702B2 (en) 2008-12-08 2014-11-25 City Of Hope Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies
SG172060A1 (en) 2008-12-09 2011-07-28 Gilead Sciences Inc Modulators of toll-like receptors
AU2010203353B2 (en) 2009-01-12 2016-06-16 Cytomx Therapeutics, Inc Modified antibody compositions, methods of making and using thereof
PL2427485T3 (pl) 2009-05-07 2017-10-31 Immunocellular Therapeutics Ltd Epitopy CD133
US20110077263A1 (en) 2009-09-29 2011-03-31 University Of Southern California Methods and Compositions of Toll-Like Receptor (TLR) Agonists
PL2504364T3 (pl) 2009-11-24 2017-12-29 Medimmune Limited Ukierunkowane środki wiążące przeciwko B7-H1
WO2011084726A1 (fr) 2009-12-21 2011-07-14 3M Innovative Properties Company Compositions à base de a[bis [4-amino-2-(éthoxyméthyl)-1-(2-hydroxy-2-méthylpropyl)-1h-imidazo[4,5-c]quinolin-5-ium]a4-[(3-carboxylato-2-hydroxynaphtalén-1-yl)méthyl]-3-hydroxynaphtalène-2-carboxylate de [aa] et procédés correspondants
WO2011084725A1 (fr) 2009-12-21 2011-07-14 3M Innovative Properties Company Compositions de 1-hydroxynaphtalène-2-carboxylate de 4-amino-2-(éthoxyméthyl)-1-(2-hydroxy-2-méthylpropyl)-1h-imidazo[4,5-c]quinolin-5-ium et procédés correspondants
MX339621B (es) 2010-04-13 2016-06-02 Celldex Therapeutics Inc * Anticuerpos que se unen a cd27 humano y uso de los mismos.
EP3388081A1 (fr) 2010-05-26 2018-10-17 Selecta Biosciences, Inc. Vaccins à nanovecteurs synthétiques multivalents
US20120039916A1 (en) 2010-08-13 2012-02-16 Baylor Research Institute Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
AU2011338383A1 (en) 2010-12-09 2012-06-14 Genentech, Inc. Treatment of HER2-positive cancer with paclitaxel and trastuzumab-MCC-DM1
US9266533B2 (en) * 2010-12-30 2016-02-23 Institute Of Automation, Chinese Academy Of Sciences Adaptive cruise control system and method for vehicle
JP5985510B2 (ja) 2011-01-12 2016-09-06 ベンティアールエックス ファーマシューティカルズ, インコーポレイテッドVentiRx Pharmaceuticals,Inc. Toll様受容体調節薬としての置換ベンゾアゼピン
WO2012122396A1 (fr) 2011-03-08 2012-09-13 Baylor Research Institute Nouveaux adjuvants pour vaccins basés sur des adjuvants de ciblage direct d'anticorps dirigés contre des cellules présentatrices d'antigènes
RU2625034C2 (ru) 2011-04-20 2017-07-11 МЕДИММЬЮН, ЭлЭлСи Антитела и другие молекулы, которые связывают в7-н1 и pd-1
EA034193B1 (ru) 2011-04-21 2020-01-15 Оригенис Гмбх Гетероциклические соединения в качестве ингибиторов киназ
US8728486B2 (en) 2011-05-18 2014-05-20 University Of Kansas Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
AU2012288413B2 (en) 2011-07-24 2016-10-13 Curetech Ltd. Variants of humanized immunomodulatory monoclonal antibodies
KR20190133790A (ko) 2011-08-01 2019-12-03 제넨테크, 인크. Pd-1 축 결합 길항제 및 mek 억제제를 사용하는 암 치료 방법
RU2014109014A (ru) 2011-08-11 2015-09-20 ХАНТСМАН ЭДВАНСТ МАТИРИАЛЗ АМЕРИКАС ЭлЭлСи Способ получения соединений бензоксазина
EP2758080B1 (fr) 2011-09-19 2018-03-07 The Johns Hopkins University Immunothérapie anticancéreuse
US11707409B2 (en) 2011-10-25 2023-07-25 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
EP2776070A4 (fr) 2011-11-09 2016-02-10 Ascend Biopharmaceuticals Ltd Conjugués immunomodulateurs
DK2785375T3 (da) 2011-11-28 2020-10-12 Merck Patent Gmbh Anti-pd-l1-antistoffer og anvendelser deraf
WO2013166110A1 (fr) 2012-05-02 2013-11-07 Yale University Molécules de recrutement d'anticorps conjugués à un agoniste de tlr)
SG10201700698WA (en) 2012-05-15 2017-02-27 Bristol Myers Squibb Co Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
CN104936982B (zh) 2012-08-03 2020-04-24 丹娜法伯癌症研究院 抗-pd-l1和pd-l2双结合抗体单一试剂及其使用方法
KR102355959B1 (ko) 2012-08-23 2022-01-27 어젠시스 인코포레이티드 158p1d7 단백질에 결합하는 항체 약물 컨쥬게이트(adc)
WO2014060112A1 (fr) 2012-10-19 2014-04-24 Origenis Gmbh Pyrazolo[4,3-d]pyrimidines utiles en tant qu'inhibiteurs de kinases
US10000482B2 (en) 2012-10-19 2018-06-19 Origenis Gmbh Kinase inhibitors
EP2787005A1 (fr) 2013-04-02 2014-10-08 Activartis Biotech GmbH Thérapie immunitaire contre le cancer ciblé
NZ721908A (en) * 2013-12-20 2022-12-23 Massachusetts Gen Hospital Combination therapy with neoantigen vaccine
AU2015205756A1 (en) 2014-01-10 2016-07-21 Birdie Biopharmaceuticals Inc. Compounds and compositions for treating EGFR expressing tumors
AU2015279738A1 (en) * 2014-06-25 2016-12-22 Selecta Biosciences, Inc. Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors
EP4001311A1 (fr) 2014-07-09 2022-05-25 Birdie Biopharmaceuticals Inc. Combinaisons anti-pd-l1 pour le traitement des tumeurs
CN112546230A (zh) 2014-07-09 2021-03-26 博笛生物科技有限公司 用于治疗癌症的联合治疗组合物和联合治疗方法
CN112546238A (zh) 2014-09-01 2021-03-26 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
CN105732635A (zh) 2014-12-29 2016-07-06 南京明德新药研发股份有限公司 一类Toll样受体7激动剂
US10821127B2 (en) 2015-11-09 2020-11-03 Shaperon Inc. Composition for inhibiting myeloid-derived suppressor cells comprising decitabine or its pharmaceutically acceptable salt as active ingredient
CN106943597A (zh) 2016-01-07 2017-07-14 博笛生物科技(北京)有限公司 用于治疗肿瘤的抗-egfr组合
CN106943596A (zh) 2016-01-07 2017-07-14 博笛生物科技(北京)有限公司 用于治疗肿瘤的抗-cd20组合
CN106943598A (zh) 2016-01-07 2017-07-14 博笛生物科技(北京)有限公司 用于治疗肿瘤的抗-her2组合
CN108794467A (zh) 2017-04-27 2018-11-13 博笛生物科技有限公司 2-氨基-喹啉衍生物
AU2017419352B2 (en) 2017-06-23 2024-05-30 Birdie Biopharmaceuticals, Inc. Pharmaceutical compositions
JP2022501327A (ja) 2018-09-07 2022-01-06 バーディー バイオファーマシューティカルズ インコーポレイテッド イミダゾキノリン化合物およびその使用
US20220016152A1 (en) 2018-12-26 2022-01-20 Birdie Biopharmaceuticals, Inc. Immune modulatory combinations and methods for treating cancers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014012479A1 (fr) * 2012-07-18 2014-01-23 Shanghai Birdie Biotech, Inc. Composés pour immunothérapie ciblée
CN103566377A (zh) * 2012-07-18 2014-02-12 上海博笛生物科技有限公司 癌症的靶向免疫治疗

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘耕陶 等: "《当代药理学》", 31 May 2008, 中国协和医科大学出版社 *
陈玲 等: "全球重点治疗领域新药研究的最新进展", 《中国新药杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111757755A (zh) * 2017-12-21 2020-10-09 大日本住友制药株式会社 包含tlr7激动剂的组合药物

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