CN107074750A - 一种拆分西酞普兰中间体5‑氰二醇的方法 - Google Patents

一种拆分西酞普兰中间体5‑氰二醇的方法 Download PDF

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CN107074750A
CN107074750A CN201480081785.8A CN201480081785A CN107074750A CN 107074750 A CN107074750 A CN 107074750A CN 201480081785 A CN201480081785 A CN 201480081785A CN 107074750 A CN107074750 A CN 107074750A
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ether
solvent
ethylene glycol
water
resolving
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CN107074750B (zh
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梁尊俊
胡斯琪
彭才华
黄文峰
芦启锋
涂国良
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Zhejiang Huahai Pharmaceutical Co Ltd
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Zhejiang Huahai Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

提供了一种拆分式4‑[4‑二甲氨基‑1‑(4‑氟苯基)‑1‑羟基丁基]‑3‑羟甲基苯腈为其对映异构体的方法，包括以下步骤：在拆分溶剂中结晶出(S)‑4‑[4‑二甲氨基‑1‑(4‑氟苯基)‑1‑羟基丁基]‑3‑羟甲基苯腈与拆分剂D‑(+)二对甲苯甲酰酒石酸形成的盐；其特征在于所述的拆分溶剂为醚类溶剂。还提供了拆分中间体新晶型。

Description

PCT国内申请，说明书已公开。

Claims (8)

  1. PCT国内申请，权利要求书已公开。
CN201480081785.8A 2014-11-14 2014-11-14 一种拆分西酞普兰中间体5-氰二醇的方法 Active CN107074750B (zh)

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PCT/CN2014/091139 WO2016074225A1 (zh) 2014-11-14 2014-11-14 一种拆分西酞普兰中间体5-氰二醇的方法

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CN107074750B CN107074750B (zh) 2022-03-25

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US (2) US10287240B2 (zh)
EP (1) EP3219702B1 (zh)
CN (1) CN107074750B (zh)
ES (1) ES2881105T3 (zh)
WO (1) WO2016074225A1 (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
CN101460448A (zh) * 2006-01-23 2009-06-17 桑多斯股份公司 羰基不对称烷基化
US20110092719A1 (en) * 2008-06-16 2011-04-21 Shodhana Laboratories Limited Preparation of Escitalopram, Its Salts and Intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
WO2007012954A1 (en) * 2005-07-27 2007-02-01 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
FI121570B (fi) 2007-09-11 2011-01-14 Lundbeck & Co As H Menetelmä essitalopraamin valmistamiseksi
JP5256749B2 (ja) * 2008-01-23 2013-08-07 住友化学株式会社 乳剤組成物
CN101265215B (zh) * 2008-04-18 2011-03-16 浙江奥托康制药集团股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
CN102190600B (zh) * 2010-03-13 2015-04-15 浙江华海药业股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts
CN101460448A (zh) * 2006-01-23 2009-06-17 桑多斯股份公司 羰基不对称烷基化
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
US20110092719A1 (en) * 2008-06-16 2011-04-21 Shodhana Laboratories Limited Preparation of Escitalopram, Its Salts and Intermediates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
姚忠科，阚丽娟: "草酸依地普仑的合成", 《中国新药杂志》 *
金俊华 等: "草酸依地普仑的合成", 《广州化工》 *

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US10287240B2 (en) 2019-05-14
US10508076B2 (en) 2019-12-17
WO2016074225A1 (zh) 2016-05-19
US20190185418A1 (en) 2019-06-20
US20170240505A1 (en) 2017-08-24
EP3219702A1 (en) 2017-09-20
CN107074750B (zh) 2022-03-25
ES2881105T3 (es) 2021-11-26
EP3219702A4 (en) 2018-05-30
EP3219702B1 (en) 2021-05-05

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