CN107033233A - 非糖基化蛋白质的纯化 - Google Patents
非糖基化蛋白质的纯化 Download PDFInfo
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- CN107033233A CN107033233A CN201710044891.4A CN201710044891A CN107033233A CN 107033233 A CN107033233 A CN 107033233A CN 201710044891 A CN201710044891 A CN 201710044891A CN 107033233 A CN107033233 A CN 107033233A
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- 229920000915 polyvinyl chloride Polymers 0.000 description 1
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- 239000001508 potassium citrate Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP08000884 | 2008-01-18 | ||
| EP08000884.0 | 2008-01-18 | ||
| CN2009801023313A CN101918430A (zh) | 2008-01-18 | 2009-01-15 | 非糖基化蛋白质的纯化 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2009801023313A Division CN101918430A (zh) | 2008-01-18 | 2009-01-15 | 非糖基化蛋白质的纯化 |
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| CN107033233A true CN107033233A (zh) | 2017-08-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710044891.4A Pending CN107033233A (zh) | 2008-01-18 | 2009-01-15 | 非糖基化蛋白质的纯化 |
| CN2009801023313A Pending CN101918430A (zh) | 2008-01-18 | 2009-01-15 | 非糖基化蛋白质的纯化 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801023313A Pending CN101918430A (zh) | 2008-01-18 | 2009-01-15 | 非糖基化蛋白质的纯化 |
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| Country | Link |
|---|---|
| US (3) | US20110034672A1 (enExample) |
| EP (1) | EP2245044A2 (enExample) |
| JP (2) | JP5944101B2 (enExample) |
| KR (1) | KR20100103595A (enExample) |
| CN (2) | CN107033233A (enExample) |
| AU (1) | AU2009204998B2 (enExample) |
| CA (1) | CA2711375C (enExample) |
| IL (1) | IL206158A (enExample) |
| WO (1) | WO2009090056A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009090056A2 (en) * | 2008-01-18 | 2009-07-23 | F. Hoffmann-La Roche Ag | Purification of not-glycosylated polypeptides |
| DE102009032179A1 (de) * | 2009-07-07 | 2011-01-13 | Biogenerix Ag | Verfahren zur Reinigung von Interferon beta |
| CN102219848B (zh) * | 2011-05-25 | 2014-01-22 | 浙江海正药业股份有限公司 | 重组人干扰素β-1a的纯化方法 |
| US20140154233A1 (en) | 2012-12-05 | 2014-06-05 | Csl Limited | Method of purifying therapeutic proteins |
| US10188965B2 (en) | 2012-12-05 | 2019-01-29 | Csl Behring Gmbh | Hydrophobic charge induction chromatographic depletion of a protein from a solution |
| CN104710527B (zh) * | 2015-02-28 | 2018-08-24 | 苏州金盟生物技术有限公司 | 一种生物制品的内毒素去除方法 |
| KR102775456B1 (ko) * | 2015-11-09 | 2025-02-28 | 바이오로지칼 이 리미티드 | 생물학적 활성 재조합 캐리어 단백질을 회수하기 위한 산업적 확장성이 있는 방법 |
| TW202128264A (zh) * | 2019-09-25 | 2021-08-01 | 瑞士商赫孚孟拉羅股份公司 | 使用經預測之溶離緩衝鹽濃度的陽離子層析法 |
| CA3179177A1 (en) * | 2020-12-23 | 2022-06-30 | Jazz Pharmaceuticals Ireland Ltd. | Methods of purifying charge-shielded fusion proteins |
| CN113480632B (zh) * | 2021-07-30 | 2023-02-03 | 宁波人健药业集团股份有限公司 | 一种在CHO细胞中表达的重组蛋白rhCG纯化工艺 |
| TW202403043A (zh) | 2022-03-18 | 2024-01-16 | 美商健臻公司 | 重組人類酸性鞘磷脂酶醫藥組合物及方法 |
| CN117024561B (zh) * | 2023-10-10 | 2024-02-20 | 哈药集团生物工程有限公司 | 一种聚乙二醇修饰干扰素的纯化方法 |
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| CN1099799A (zh) * | 1993-05-26 | 1995-03-08 | 贝林格尔-英格海姆国际有限公司 | 制备和纯化α-干扰素的方法 |
| DE4329756A1 (de) * | 1993-09-03 | 1995-03-09 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
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- 2009-01-15 US US12/811,397 patent/US20110034672A1/en not_active Abandoned
- 2009-01-15 CA CA2711375A patent/CA2711375C/en not_active Expired - Fee Related
- 2009-01-15 KR KR1020107015694A patent/KR20100103595A/ko not_active Ceased
- 2009-01-15 CN CN201710044891.4A patent/CN107033233A/zh active Pending
- 2009-01-15 AU AU2009204998A patent/AU2009204998B2/en not_active Ceased
- 2009-01-15 EP EP09702937A patent/EP2245044A2/en not_active Withdrawn
- 2009-01-15 JP JP2010542579A patent/JP5944101B2/ja not_active Expired - Fee Related
- 2009-01-15 CN CN2009801023313A patent/CN101918430A/zh active Pending
-
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Also Published As
| Publication number | Publication date |
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| US20110034672A1 (en) | 2011-02-10 |
| WO2009090056A3 (en) | 2010-01-21 |
| US9481706B2 (en) | 2016-11-01 |
| JP2014210797A (ja) | 2014-11-13 |
| US20140220633A1 (en) | 2014-08-07 |
| CA2711375C (en) | 2019-04-16 |
| IL206158A0 (en) | 2010-12-30 |
| CN101918430A (zh) | 2010-12-15 |
| AU2009204998A1 (en) | 2009-07-23 |
| EP2245044A2 (en) | 2010-11-03 |
| CA2711375A1 (en) | 2009-07-23 |
| US20130190478A1 (en) | 2013-07-25 |
| IL206158A (en) | 2016-09-29 |
| JP2011509963A (ja) | 2011-03-31 |
| WO2009090056A2 (en) | 2009-07-23 |
| KR20100103595A (ko) | 2010-09-27 |
| JP5944101B2 (ja) | 2016-07-05 |
| AU2009204998B2 (en) | 2014-03-27 |
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Application publication date: 20170811 |