CN106939005A - 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 - Google Patents
晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 Download PDFInfo
- Publication number
- CN106939005A CN106939005A CN201710173425.6A CN201710173425A CN106939005A CN 106939005 A CN106939005 A CN 106939005A CN 201710173425 A CN201710173425 A CN 201710173425A CN 106939005 A CN106939005 A CN 106939005A
- Authority
- CN
- China
- Prior art keywords
- ray diffraction
- dimethyl
- phenyl
- dihydro
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*(*)N(C)[C@](CC1)(CC[C@]11OCCc(c2c3)c1[n]c2ccc3F)c1ccccc1 Chemical compound C*(*)N(C)[C@](CC1)(CC[C@]11OCCc(c2c3)c1[n]c2ccc3F)c1ccccc1 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11005587 | 2011-07-08 | ||
| EP11005587.8 | 2011-07-08 | ||
| CN201280032432.XA CN103649094B (zh) | 2011-07-08 | 2012-07-06 | 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280032432.XA Division CN103649094B (zh) | 2011-07-08 | 2012-07-06 | 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106939005A true CN106939005A (zh) | 2017-07-11 |
Family
ID=46717800
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710173425.6A Pending CN106939005A (zh) | 2011-07-08 | 2012-07-06 | 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 |
| CN201280032432.XA Active CN103649094B (zh) | 2011-07-08 | 2012-07-06 | 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280032432.XA Active CN103649094B (zh) | 2011-07-08 | 2012-07-06 | 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 |
Country Status (23)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8618156B2 (en) * | 2011-07-08 | 2013-12-31 | Gruenenthal Gmbh | Crystalline (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
| CN107427493A (zh) | 2015-01-23 | 2017-12-01 | 格吕伦塔尔有限公司 | 用于治疗肝功能受损和/或肾功能受损的受试者的疼痛的Cebranopadol |
| US20180021304A1 (en) | 2015-02-02 | 2018-01-25 | Ratiopharm Gmbh | Composition comprising cebranopadol in a dissolved form |
| MX2018010367A (es) | 2016-02-29 | 2018-12-10 | Guenenthal Gmbh | Titulacion de cebranopadol. |
| JP7365073B2 (ja) * | 2019-05-21 | 2023-10-19 | ジァンスー フォアフロント ファーマシューティカル カンパニー，リミテッド | トレプロスチニルナトリウムの新規な結晶形および製造方法 |
| CN112254496A (zh) * | 2020-09-25 | 2021-01-22 | 榆林学院 | 一种煤泥收集装置 |
| WO2024129782A1 (en) | 2022-12-12 | 2024-06-20 | Park Therapeutics, Inc. | Regimens and compositions useful for alleviating pain |
| CN122458986A (zh) | 2023-02-15 | 2026-07-24 | 艾德神经立治疗公司 | 有用于缓解疼痛的方案和组合物 |
| WO2026035694A1 (en) | 2024-08-05 | 2026-02-12 | Adneuris Therapeutics, Inc. | Cebranopadol useful for preventing or reducing opioid induced respiratory depression |
| WO2026161433A1 (en) | 2025-01-21 | 2026-07-30 | Adneuris Therapeutics, Inc. | Cebranopadol useful for alleviating pain |
| WO2026161842A1 (en) | 2025-01-27 | 2026-07-30 | Adneuris Therapeutics, Inc. | Cebranopadol useful for treating pain |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735619A (zh) * | 2002-11-11 | 2006-02-15 | 格吕伦塔尔有限公司 | 螺环环己烷衍生物 |
| WO2006108565A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit |
| WO2008009415A2 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | 4-heteroaryl-substituierte 1-aminocyclohexan-1- und cyclohexen-1-derivate mit wirkung auf das opiod rezeptor system |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| EP3459533A1 (en) * | 2010-08-04 | 2019-03-27 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for the treatment of nociceptive pain |
| US8618156B2 (en) * | 2011-07-08 | 2013-12-31 | Gruenenthal Gmbh | Crystalline (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
-
2012
- 2012-07-06 US US13/542,809 patent/US8618156B2/en active Active
- 2012-07-06 RS RS20170921A patent/RS56343B1/sr unknown
- 2012-07-06 AU AU2012283449A patent/AU2012283449B2/en not_active Ceased
- 2012-07-06 EA EA201400120A patent/EA026750B1/ru not_active IP Right Cessation
- 2012-07-06 PL PL12748646T patent/PL2729470T3/pl unknown
- 2012-07-06 AR ARP120102454A patent/AR087081A1/es not_active Application Discontinuation
- 2012-07-06 BR BR112014000358A patent/BR112014000358A2/pt not_active IP Right Cessation
- 2012-07-06 PT PT127486462T patent/PT2729470T/pt unknown
- 2012-07-06 MX MX2014000297A patent/MX2014000297A/es unknown
- 2012-07-06 SI SI201231030T patent/SI2729470T1/sl unknown
- 2012-07-06 DK DK12748646.2T patent/DK2729470T3/en active
- 2012-07-06 LT LTEP12748646.2T patent/LT2729470T/lt unknown
- 2012-07-06 CN CN201710173425.6A patent/CN106939005A/zh active Pending
- 2012-07-06 TW TW101124343A patent/TWI585092B/zh not_active IP Right Cessation
- 2012-07-06 ES ES12748646.2T patent/ES2641299T3/es active Active
- 2012-07-06 WO PCT/EP2012/002839 patent/WO2013007361A1/en not_active Ceased
- 2012-07-06 CN CN201280032432.XA patent/CN103649094B/zh active Active
- 2012-07-06 HR HRP20170968TT patent/HRP20170968T1/hr unknown
- 2012-07-06 DK DK17020200.6T patent/DK3235821T3/da active
- 2012-07-06 HU HUE12748646A patent/HUE033043T2/hu unknown
- 2012-07-06 CA CA2841032A patent/CA2841032C/en active Active
- 2012-07-06 EP EP12748646.2A patent/EP2729470B1/en active Active
- 2012-07-06 JP JP2014517519A patent/JP6276689B2/ja active Active
- 2012-07-06 EP EP17020200.6A patent/EP3235821B1/en active Active
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2013
- 2013-03-15 US US13/835,298 patent/US8765800B2/en active Active
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2014
- 2014-01-06 IL IL230331A patent/IL230331B/en unknown
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2017
- 2017-01-12 JP JP2017003194A patent/JP6559165B2/ja active Active
- 2017-07-04 AU AU2017204572A patent/AU2017204572B2/en not_active Ceased
- 2017-08-02 CY CY20171100830T patent/CY1120525T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735619A (zh) * | 2002-11-11 | 2006-02-15 | 格吕伦塔尔有限公司 | 螺环环己烷衍生物 |
| WO2006108565A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit |
| WO2008009415A2 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | 4-heteroaryl-substituierte 1-aminocyclohexan-1- und cyclohexen-1-derivate mit wirkung auf das opiod rezeptor system |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned | ||
| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20200911 |