CA2841032C - Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine - Google Patents

Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine Download PDF

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CA2841032C
CA2841032C CA2841032A CA2841032A CA2841032C CA 2841032 C CA2841032 C CA 2841032C CA 2841032 A CA2841032 A CA 2841032A CA 2841032 A CA2841032 A CA 2841032A CA 2841032 C CA2841032 C CA 2841032C
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crystalline form
pharmaceutical composition
active ingredient
theta
use according
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French (fr)
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CA2841032A1 (en
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Michael Gruss
Stefan Pruhs
Stefan Kluge
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Park Therapeutics Inc
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Grünenthal GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CA2841032A 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine Active CA2841032C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
EP11005587.8 2011-07-08
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (2)

Publication Number Publication Date
CA2841032A1 CA2841032A1 (en) 2013-01-17
CA2841032C true CA2841032C (en) 2020-12-15

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CA2841032A Active CA2841032C (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Country Status (23)

Country Link
US (2) US8618156B2 (cg-RX-API-DMAC10.html)
EP (2) EP2729470B1 (cg-RX-API-DMAC10.html)
JP (2) JP6276689B2 (cg-RX-API-DMAC10.html)
CN (2) CN106939005A (cg-RX-API-DMAC10.html)
AR (1) AR087081A1 (cg-RX-API-DMAC10.html)
AU (2) AU2012283449B2 (cg-RX-API-DMAC10.html)
BR (1) BR112014000358A2 (cg-RX-API-DMAC10.html)
CA (1) CA2841032C (cg-RX-API-DMAC10.html)
CY (1) CY1120525T1 (cg-RX-API-DMAC10.html)
DK (2) DK2729470T3 (cg-RX-API-DMAC10.html)
EA (1) EA026750B1 (cg-RX-API-DMAC10.html)
ES (1) ES2641299T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20170968T1 (cg-RX-API-DMAC10.html)
HU (1) HUE033043T2 (cg-RX-API-DMAC10.html)
IL (1) IL230331B (cg-RX-API-DMAC10.html)
LT (1) LT2729470T (cg-RX-API-DMAC10.html)
MX (1) MX2014000297A (cg-RX-API-DMAC10.html)
PL (1) PL2729470T3 (cg-RX-API-DMAC10.html)
PT (1) PT2729470T (cg-RX-API-DMAC10.html)
RS (1) RS56343B1 (cg-RX-API-DMAC10.html)
SI (1) SI2729470T1 (cg-RX-API-DMAC10.html)
TW (1) TWI585092B (cg-RX-API-DMAC10.html)
WO (1) WO2013007361A1 (cg-RX-API-DMAC10.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8618156B2 (en) * 2011-07-08 2013-12-31 Gruenenthal Gmbh Crystalline (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
CN107427493A (zh) 2015-01-23 2017-12-01 格吕伦塔尔有限公司 用于治疗肝功能受损和/或肾功能受损的受试者的疼痛的Cebranopadol
US20180021304A1 (en) 2015-02-02 2018-01-25 Ratiopharm Gmbh Composition comprising cebranopadol in a dissolved form
MX2018010367A (es) 2016-02-29 2018-12-10 Guenenthal Gmbh Titulacion de cebranopadol.
JP7365073B2 (ja) * 2019-05-21 2023-10-19 ジァンスー フォアフロント ファーマシューティカル カンパニー，リミテッド トレプロスチニルナトリウムの新規な結晶形および製造方法
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
CN122458986A (zh) 2023-02-15 2026-07-24 艾德神经立治疗公司 有用于缓解疼痛的方案和组合物
WO2026035694A1 (en) 2024-08-05 2026-02-12 Adneuris Therapeutics, Inc. Cebranopadol useful for preventing or reducing opioid induced respiratory depression
WO2026161433A1 (en) 2025-01-21 2026-07-30 Adneuris Therapeutics, Inc. Cebranopadol useful for alleviating pain
WO2026161842A1 (en) 2025-01-27 2026-07-30 Adneuris Therapeutics, Inc. Cebranopadol useful for treating pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EP3459533A1 (en) * 2010-08-04 2019-03-27 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for the treatment of nociceptive pain
US8618156B2 (en) * 2011-07-08 2013-12-31 Gruenenthal Gmbh Crystalline (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

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Publication number Publication date
DK3235821T3 (da) 2020-04-20
CY1120525T1 (el) 2019-07-10
EP2729470A1 (en) 2014-05-14
JP2017081981A (ja) 2017-05-18
MX2014000297A (es) 2014-01-31
CA2841032A1 (en) 2013-01-17
HUE033043T2 (hu) 2017-11-28
SI2729470T1 (sl) 2017-10-30
US20130012563A1 (en) 2013-01-10
JP6559165B2 (ja) 2019-08-14
EP3235821B1 (en) 2020-04-08
ES2641299T3 (es) 2017-11-08
WO2013007361A8 (en) 2013-04-04
HRP20170968T1 (hr) 2017-09-22
DK2729470T3 (en) 2017-09-11
TW201311694A (zh) 2013-03-16
US20130231381A1 (en) 2013-09-05
PT2729470T (pt) 2017-10-02
EP3235821A1 (en) 2017-10-25
BR112014000358A2 (pt) 2017-01-10
US8618156B2 (en) 2013-12-31
AU2012283449A8 (en) 2014-03-27
JP6276689B2 (ja) 2018-02-07
RS56343B1 (sr) 2017-12-29
CN103649094B (zh) 2017-05-24
WO2013007361A9 (en) 2013-12-27
AR087081A1 (es) 2014-02-12
WO2013007361A1 (en) 2013-01-17
PL2729470T3 (pl) 2017-11-30
AU2012283449B2 (en) 2017-04-06
US8765800B2 (en) 2014-07-01
AU2017204572A1 (en) 2017-07-27
TWI585092B (zh) 2017-06-01
CN106939005A (zh) 2017-07-11
JP2014518226A (ja) 2014-07-28
AU2017204572B2 (en) 2018-05-24
EA201400120A1 (ru) 2014-06-30
LT2729470T (lt) 2017-08-25
EA026750B1 (ru) 2017-05-31
CN103649094A (zh) 2014-03-19
IL230331B (en) 2018-11-29
EP2729470B1 (en) 2017-06-21
AU2012283449A1 (en) 2014-02-20

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