CN1068597C - 制备4－芳基－哌啶衍生物的方法 - Google Patents

制备4－芳基－哌啶衍生物的方法 Download PDF

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Publication number
CN1068597C
CN1068597C CN96193942A CN96193942A CN1068597C CN 1068597 C CN1068597 C CN 1068597C CN 96193942 A CN96193942 A CN 96193942A CN 96193942 A CN96193942 A CN 96193942A CN 1068597 C CN1068597 C CN 1068597C
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CN
China
Prior art keywords
compound
formula
limits
alkyl
above group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96193942A
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English (en)
Chinese (zh)
Other versions
CN1184476A (zh
Inventor
J·B·汉森
S·特雷潘达尔
M·恩格尔斯托福特
B·苯茨恩
S·莱曼
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Novo Nordisk AS
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Novo Nordisk AS
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Publication date
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Publication of CN1184476A publication Critical patent/CN1184476A/zh
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Publication of CN1068597C publication Critical patent/CN1068597C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN96193942A 1995-05-17 1996-04-25 制备4－芳基－哌啶衍生物的方法 Expired - Fee Related CN1068597C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK56395 1995-05-17
DK0563/1995 1995-05-17
DK0563/95 1995-05-17

Publications (2)

Publication Number Publication Date
CN1184476A CN1184476A (zh) 1998-06-10
CN1068597C true CN1068597C (zh) 2001-07-18

Family

ID=8094959

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96193942A Expired - Fee Related CN1068597C (zh) 1995-05-17 1996-04-25 制备4－芳基－哌啶衍生物的方法

Country Status (11)

Country Link
EP (1) EP0828735A1 (ja)
JP (1) JPH11505229A (ja)
CN (1) CN1068597C (ja)
AU (1) AU721257B2 (ja)
BR (1) BR9608471A (ja)
CA (1) CA2220963A1 (ja)
HU (1) HUP9900318A3 (ja)
IL (1) IL118294A0 (ja)
NZ (1) NZ307479A (ja)
WO (1) WO1996036636A1 (ja)
ZA (1) ZA963951B (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9526645D0 (en) * 1995-12-28 1996-02-28 Chiroscience Ltd Stereoselective synthesis
ES2117557B1 (es) * 1996-02-29 1999-07-01 Ferrer Int Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.
EP1384711A1 (en) 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Optical resolution of a piperidine derivative
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
GB9700690D0 (en) 1997-01-15 1997-03-05 Smithkline Beecham Plc Novel process
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
AP9901698A0 (en) 1997-05-29 1999-12-31 Smithkline Beecham Corp Novel process.
SI0994872T1 (ja) * 1997-06-10 2001-08-31 Synthon Bv
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
GB9826175D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
IT1308629B1 (it) * 1999-02-23 2002-01-09 Recordati Chem Pharm Processo per la produzione di paroxetina.
IT1313702B1 (it) 1999-08-02 2002-09-09 Chemi Spa Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.
AU1018801A (en) * 1999-10-29 2001-05-14 Novo Nordisk A/S Use of 3,4-substituted piperidines
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
WO2001085688A1 (en) 2000-05-12 2001-11-15 Synthon B.V. TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS
WO2002006275A1 (en) * 2000-07-17 2002-01-24 Smithkline Beecham P.L.C. Novel processes for the preparation of 4-phenylpiperidine derivatives
GB0021147D0 (en) * 2000-08-30 2000-10-11 Knoll Ag Chemical process
GB0021145D0 (en) * 2000-08-30 2000-10-11 Knoll Ag Chemical process
WO2002028834A1 (en) * 2000-10-06 2002-04-11 Smithkline Beecham P.L.C. Process for the preparation of aryl-piperidine carbinols and intermediates thereof
EP1347960B1 (en) * 2001-01-04 2004-11-17 Ferrer Internacional, S.A. Process for preparing (+) trans-4-p-fluorophenyl-3-hydroxymethyl-1
WO2015071831A1 (en) * 2013-11-18 2015-05-21 Piramal Enterprises Limited An improved process for minimising the formation of dehalogenated byproducts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4593036A (en) * 1984-02-07 1986-06-03 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)methyl]-1-methylpiperidine useful as 5-HT potentiator
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater

Also Published As

Publication number Publication date
CA2220963A1 (en) 1996-11-21
ZA963951B (en) 1997-01-21
NZ307479A (en) 1999-08-30
IL118294A0 (en) 1996-09-12
HUP9900318A2 (hu) 1999-09-28
HUP9900318A3 (en) 2001-09-28
EP0828735A1 (en) 1998-03-18
AU5684596A (en) 1996-11-29
AU721257B2 (en) 2000-06-29
CN1184476A (zh) 1998-06-10
JPH11505229A (ja) 1999-05-18
WO1996036636A1 (en) 1996-11-21
BR9608471A (pt) 1998-12-29

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