CN106668784A - 一种治疗子宫内膜移位症的药物及其制备方法 - Google Patents
一种治疗子宫内膜移位症的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗子宫内膜移位症的药物及其制备方法,其主要是由当归、丹参、牛膝、赤芍、香附、川芎、桂枝、没药、五灵脂、蒲黄、血竭、红花、桃仁、益母草、三棱、莪术、白术、刘寄奴、牡丹皮、延胡索、甘草按一定重量配比制备而成,本发明药物具有清热凉血,散瘀止痛,理气解郁,止痛调经,行气开郁的功能,用于治疗子宫内膜移位症见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗子宫内膜移位症的药物及其制备方法,属中药领域。
背景技术
子宫内膜移位症是指有活性的内膜细胞种植在子宫内膜以外的位置而形成的一种女性常见妇科疾病。内膜细胞本该生长在子宫腔内,但由于子宫腔通过输卵管与盆腔相通,因此使得内膜细胞可经由输卵管进入盆腔异位生长。目前对此病发病的机制有多种说法,其中被普遍认可的是子宫内膜种植学说。本病多发生于生育年龄的女性,青春期前不发病,绝经后异位病灶可逐渐萎缩退化。由于西药治疗副作用大,因此人们对有效治疗子宫内膜移位症的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗子宫内膜移位症的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗子宫内膜移位症的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择当归、丹参、牛膝、赤芍、香附、川芎、桂枝、没药、五灵脂、蒲黄、血竭、红花、桃仁、益母草、三棱、莪术、白术、刘寄奴、牡丹皮、延胡索、甘草、没药、山楂、草豆蔻、麦芽、建神曲、半夏进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗子宫内膜移位症。其中选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。选用五灵脂是因为其性味苦甘,温,入肝、脾经,生用有行血止痛的功能,治心腹血气诸痛,妇女经闭,产后瘀血作痛;外治蛇、蝎、蜈蚣咬伤,炒用止血,治妇女血崩,经水过多,赤带不绝。选用蒲黄是因为其性味甘辛苦,凉,入肝、心经,有凉血止血,活血消瘀的功能,生用治经闭腹痛,产后瘀阻作痛,跌扑血闷,疮疖肿毒,炒黑止吐血,衄血,崩漏,泻血,尿血,血痢,带下,外治重舌,口疮,聤耳流脓,耳中出血,阴下湿痒。选用血竭是因为其性味甘咸,平,入心、肝经,有散瘀定痛,止血生肌的功能,治跌打折损,内伤瘀痛,外伤出血不止,瘰疬,臁疮溃久不合。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用益母草是因为其性味辛苦,凉,入心包、肝经,有活血,祛瘀,调经,消水的功能,治月经不调,治漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。选用三棱是因为其性味苦辛,平,入肝、脾经,有破血,行气,消积,止痛的功能,治癥瘕积聚,气血凝带,心腹疼痛,胁下胀疼,经闭,产后瘀血腹痛,跌打损伤,疮肿坚硬。选用莪术是因为其性味辛、苦、温。归肝、脾经。行气破血,消积止痛。用于癥瘕痞块,瘀血经闭,食积胀痛,跌打肿痛,早期宫颈癌。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用刘寄奴是因为其性味苦,温,入心、脾经,有破血通经,敛疮消肿的功能,治经闭癥瘕,胸腹胀痛,产后血瘀,跌打损伤,金疮出血,痈毒焮肿。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用,治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊癎;生用,治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用草豆蔻是因为其性味辛,温,入脾、胃经,有温中,祛寒,行气,燥湿的功能,治心腹冷痛,痞满食滞,噎膈反胃,寒湿吐泻,痰饮积聚。选用麦芽是因为其性味甘,微温,入脾、胃经,有消食,和中,下气的功能,治食积不消,胀腹胀满,食欲不振,呕吐泄泻,乳胀不消。选用建神曲是因为其性味苦,温,有健脾消食,理气化湿,解表的功能,治伤食胸痞,腹痛吐泻,痢疾,感冒头痛,小儿伤饥失饱。选用半夏是因为其性味辛,温,有毒,入脾、胃经,有燥湿化痰,降逆止呕,消痞散结的功能,治湿痰冷饮,呕吐,反胃,咳喘痰多,胸膈胀满,痰厥头痛,头晕不眠,外消痈肿。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
当归5-15克,丹参5-15克,牛膝10-14克,赤芍10-14克,香附7-11克,川芎4-8克,桂枝5-10克,没药4-8克,五灵脂10-14克,蒲黄10-14克,血竭2-3克,红花5-15克,桃仁5-15克,益母草15-25克,三棱10-14克,莪术5-15克,白术5-15克,刘寄奴5-15克,牡丹皮10-20克,延胡索5-15克,甘草5-15克,没药10-20克,山楂5-15克,草豆蔻10-14克,麦芽10-20克,建神曲5-15克,半夏5-15克。
优选为:
当归10克,丹参10克,牛膝12克,赤芍12克,香附9克,川芎6克,桂枝5克,没药6克,五灵脂12克,蒲黄12克,血竭3克,红花10克,桃仁10克,益母草20克,三棱12克,莪术10克,白术10克,刘寄奴10克,牡丹皮15克,延胡索10克,甘草10克,没药15克,山楂10克,草豆蔻12克,麦芽15克,建神曲10克,半夏10克。
本发明药物的制备方法如下
一、备料
1、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
2、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
3、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
4、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
5、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
6、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
7、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
8、没药:拣去杂质,打成碎块;
9、五灵脂:拣净杂质,打碎或筛去灰屑;
10、生蒲黄:揉碎结块,过筛,除去杂质;、
11、血竭:拭去灰尘,敲成小块,于冬季干燥天气,放在石灰坛内使燥,然后乘脆研末;
12、红花:拣净杂质,除去茎叶、蒂头,晒干;
13、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
14、益母草:拣去杂质,洗净,润透,切段,晒干;
15、三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
16、莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
17、白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
18、刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
19、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
20、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
21、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
22、没药:拣去杂质,打成碎块;
23、山楂:拣净杂质,筛去核;
24、草豆蔻:拣净杂质,去壳取仁,用时捣碎;
25、麦芽:取麦芽置锅内微炒至黄色,取出放凉;
26、建神曲:原品入药;
27、半夏:拣去杂质,筛去灰屑。
二、制备
1、将所述重量的当归、丹参、牛膝、赤芍、香附、川芎、桂枝、没药、五灵脂、蒲黄、红花、桃仁、益母草、三棱、莪术、白术、刘寄奴、牡丹皮、延胡索、甘草、没药、山楂、草豆蔻、麦芽、建神曲、半夏放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合加入血竭搅拌均匀,分为4剂服用。
组方中赤芍有清热凉血,散瘀止痛的功能为君药;香附有理气解郁,止痛调经的功能;川芎有行气开郁,祛风燥湿,活血止痛的功能,二者为臣药,三味药共同发挥清热凉血,散瘀止痛,理气解郁,止痛调经,行气开郁的作用,治疗子宫内膜移位症效力全面,且以散瘀止痛,理气解郁,止痛调经为主可治本,五灵脂有行血止痛的功能为佐药,蒲黄有凉血止血,活血消瘀的功能为使药,与下余诸药是治标。
本发明药物具有清热凉血,散瘀止痛,理气解郁,止痛调经,行气开郁的功能,用于治疗子宫内膜移位症,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治子宫内膜移位症门诊患者共34例。
2、诊断标准
子宫内膜异位症的主要病理变化为异位内膜周期性出血及其周围组织纤维化,形成异位结节,痛经、慢性盆腔痛、月经异常和不孕是其主要症状。病变可以波及所有的盆腔组织和器官,以卵巢、子宫直肠陷凹、宫骶韧带等部位最常见,也可发生于腹腔、胸腔、四肢等处。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,8天为一个疗程,连续服用4个疗程。
4、疗效评定标准
显效:子宫内膜移位症症状消失,恢复正常,痊愈;
好转:子宫内膜移位症症状明显好转,痛经及慢性盆腔痛症状减轻,移位逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗子宫内膜移位症患者34例,结果显效28例,显效率为82.3%,好转4例,好转率为11.8%,无效2例,总有效率为94.1%。
Claims (3)
1.一种治疗子宫内膜移位症的药物,其特征在于:它是由下列重量范围内的原料药制成:
当归5-15克,丹参5-15克,牛膝10-14克,赤芍10-14克,香附7-11克,川芎4-8克,桂枝5-10克,没药4-8克,五灵脂10-14克,蒲黄10-14克,血竭2-3克,红花5-15克,桃仁5-15克,益母草15-25克,三棱10-14克,莪术5-15克,白术5-15克,刘寄奴5-15克,牡丹皮10-20克,延胡索5-15克,甘草5-15克,没药10-20克,山楂5-15克,草豆蔻10-14克,麦芽10-20克,建神曲5-15克,半夏5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
当归10克,丹参10克,牛膝12克,赤芍12克,香附9克,川芎6克,桂枝5克,没药6克,五灵脂12克,蒲黄12克,血竭3克,红花10克,桃仁10克,益母草20克,三棱12克,莪术10克,白术10克,刘寄奴10克,牡丹皮15克,延胡索10克,甘草10克,没药15克,山楂10克,草豆蔻12克,麦芽15克,建神曲10克,半夏10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(2)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(3)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(4)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(5)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(6)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(7)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(8)没药:拣去杂质,打成碎块;
(9)五灵脂:拣净杂质,打碎或筛去灰屑;
(10)生蒲黄:揉碎结块,过筛,除去杂质;、
(11)血竭:拭去灰尘,敲成小块,于冬季干燥天气,放在石灰坛内使燥,然后乘脆研末;
(12)红花:拣净杂质,除去茎叶、蒂头,晒干;
(13)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(14)益母草:拣去杂质,洗净,润透,切段,晒干;
(15)三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
(16)莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
(17)白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
(18)刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
(19)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(20)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(21)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
(22)没药:拣去杂质,打成碎块;
(23)山楂:拣净杂质,筛去核;
(24)草豆蔻:拣净杂质,去壳取仁,用时捣碎;
(25)麦芽:取麦芽置锅内微炒至黄色,取出放凉;
(26)建神曲:原品入药;
(27)半夏:拣去杂质,筛去灰屑;
(二)制备
(1)将所述重量的当归、丹参、牛膝、赤芍、香附、川芎、桂枝、没药、五灵脂、蒲黄、红花、桃仁、益母草、三棱、莪术、白术、刘寄奴、牡丹皮、延胡索、甘草、没药、山楂、草豆蔻、麦芽、建神曲、半夏放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合加入血竭搅拌均匀,分为4剂服用。
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