CN106614671B - Mosquito repellent liquid and preparation method thereof - Google Patents
Mosquito repellent liquid and preparation method thereof Download PDFInfo
- Publication number
- CN106614671B CN106614671B CN201611237745.5A CN201611237745A CN106614671B CN 106614671 B CN106614671 B CN 106614671B CN 201611237745 A CN201611237745 A CN 201611237745A CN 106614671 B CN106614671 B CN 106614671B
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- CN
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- Prior art keywords
- mosquito repellent
- repellent liquid
- mosquito
- buffer
- chitosan
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- 239000000077 insect repellent Substances 0.000 title claims abstract description 48
- 239000007788 liquid Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229920001661 Chitosan Polymers 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000006174 pH buffer Substances 0.000 claims abstract description 14
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 claims abstract description 13
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000000484 citronellol Nutrition 0.000 claims abstract description 13
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims abstract description 12
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims abstract description 11
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims abstract description 11
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000005493 rutin Nutrition 0.000 claims abstract description 11
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims abstract description 11
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960004555 rutoside Drugs 0.000 claims abstract description 11
- QLHULAHOXSSASE-UHFFFAOYSA-N butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate Chemical compound CCC(C)OC(=O)N1CCCCC1CCO QLHULAHOXSSASE-UHFFFAOYSA-N 0.000 claims description 19
- 229950011440 icaridin Drugs 0.000 claims description 19
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical group OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 14
- 229940078916 carbamide peroxide Drugs 0.000 claims description 11
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 11
- 235000019441 ethanol Nutrition 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 10
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 7
- 229960004889 salicylic acid Drugs 0.000 claims description 5
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 3
- 229960004025 sodium salicylate Drugs 0.000 claims description 3
- 229930182478 glucoside Natural products 0.000 claims description 2
- 229960000953 salsalate Drugs 0.000 claims description 2
- 150000008131 glucosides Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 3
- 229920005552 sodium lignosulfonate Polymers 0.000 abstract 1
- 241000255925 Diptera Species 0.000 description 20
- 230000007613 environmental effect Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000001846 repelling effect Effects 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 208000002672 hepatitis B Diseases 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- 241000256059 Culex pipiens Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241000256113 Culicidae Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 235000013877 carbamide Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 230000008029 eradication Effects 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 238000005189 flocculation Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229960000490 permethrin Drugs 0.000 description 2
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 description 1
- 240000004510 Agastache rugosa Species 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 206010012310 Dengue fever Diseases 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010061192 Haemorrhagic fever Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- IKGXIBQEEMLURG-UHFFFAOYSA-N Rutin Chemical compound OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-UHFFFAOYSA-N 0.000 description 1
- 240000000203 Salix gracilistyla Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000025729 dengue disease Diseases 0.000 description 1
- 229960001673 diethyltoluamide Drugs 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- -1 rue Glucoside Chemical class 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Insects & Arthropods (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of daily chemical preparations, and particularly relates to a safe and environment-friendly mosquito repellent liquid and a preparation method thereof, wherein the mosquito repellent liquid mainly comprises the following components in percentage by mass: 4-5% of Escitin, 8-12% of chitosan, 5-7% of sodium lignosulfonate, 0.5-1.5% of pH buffer, 0.5-1% of rutin, 0.5-1% of citronellol, 1-2% of urea peroxide, 11-15% of ethanol and 50-75% of water.
Description
Technical field
The invention belongs to daily use chemicals preparation technical fields, and in particular to arrive a kind of safety and environmental protection mosquito repellent liquid and its preparation side
Method.
Background technique
Mosquito can propagate a variety of viruses, lead to the generation of human diseases, such as cause encephalitis, Hemorrhagic fever, hepatitis, hair
Hot, slight discomfort, arthritis etc., in China, mosquito main propagation dengue fever, epidemic cerebrospinal meningitis B, malaria and hepatitis B etc.
Disease.By taking hepatitis B as an example, its hepatitis b surface antigen positive recall rate of mosquito in Hepatitis B patients room is and healthy up to 85% or more
Mosquito in people room reaches infection rate less than 10%, when the blood of mosquito bite Hepatitis B patients, while also having sucked B-type hepatitis
Poison, then go to bite Healthy People, it is particularly critical will to keep away mosquito by spreading to healthy human body.
Summer and autumn are mosquito activity most rampant seasons, prevent mosquito and bite, and eliminating mosquito can be effectively pre-
The generation of above-mentioned disease is prevented, currently, common mosquito repellent mode are as follows: 1, physics mosquito repellent remove rubbish and vegetation, shut door and window, 2,
Chemical mosquito repellent is often used Metadelphene (DEET), the products such as p- terpane -3,8- glycol (PMD), but is single use this ingredient,
It is short to keep away the mosquito time, and temperature is strong, therefore, it is necessary to mosquito repellent products to need further improve.
The Chinese patent application of Publication No. 105997675A discloses a kind of containing the mosquito-repellent water of pericarpium zanthoxyli schinifolii and its preparation side
Method, main active are pericarpium zanthoxyli schinifolii, lavender, rose, wrinkled giant hyssop and the extract of peppermint, which not only has good drive
Mosquito effect, also have refresh the mind, refrigerant antipruritic, restraining and sterilizing bacteria, including the effect of skin personally instructs insect bites, still, this hair
The bright plant extracts used can volatilize completely in a short time, and mosquito repellent time is short, and mosquito repellent range is smaller.
The Chinese patent application of Publication No. 103860394A discloses a kind of long-acting mosquitos and flies repellent spray liniment of animal specific
And preparation method thereof, parts by weight of raw materials be Metadelphene 10~25, camphor 0.1~0.5, menthol 0.1~0.7, eugenol 0.5~
5, Permethrin 0.2~3, high molecular polymer 0.2~6, organic solvent 50~80；The organic solvent is alcohol, tetrahydro furan
One of which in muttering；The high molecular polymer is sodium carboxymethylcellulose, in polyvinylpyrrolidone, polyvinyl alcohol
It is one of.Permethrin will cause environmental pollution in the ingredient that the invention uses, and the invention effective component Metadelphene exists
10% or more, it cannot function as common family's ingredient, belong to pesticide scope, it is inconvenient to use.
Summary of the invention
In order to solve the deficiencies in the prior art, the present invention provides a kind of safety and environmental protection mosquito repellent liquid and its preparation sides
Method, the mosquito repellent liquid are to add other auxiliary elements on the basis of mosquito eradication active material Icaridin, make its mosquito eradication range more
Extensively, the time is more lasting.
Specific technical solution of the present invention is as follows.
A kind of safety and environmental protection mosquito repellent liquid, mainly by following mass fraction at being grouped as: Icaridin 4-5%, chitosan
8-12%, sodium lignin sulfonate 5-7%, pH buffer 0.5-1.5%, rutin 0.5-1%, citronellol 0.5-1%, peroxidating
Urea 1-2%, ethyl alcohol 11-15% and water 50-75%.
Icaridin: molecular formula C12H23NO3, structural formula:
Icaridin (Icaridin) is proved to be effective pest repellant ingredient by the World Health Organization, and form includes spray
Mist agent, mosquito-repellent water etc..Horizontal according to different dosages, active formulation is capable of providing 3-5 hours (content 10%) under normal conditions
Expelling parasite protection, is significantly better than its similar product.But no more than due to the content of Icaridin in the common mosquito-repellent water of family
5%, it is therefore desirable to add the auxiliary element of some safeties to its further synergy.
Chitosan: chitosan and its derivative has preferable antibacterial activity, can inhibit some fungies, bacterium and virus
Growth and breeding, and chitosan has good flocculation, can not only sterilize, can also play catharsis to air,
Importantly, chitosan skin-friendly is good, it is nonirritant.
Rutin (CAS:153-18-4): rue is a kind of common mosquito repellent plant, and wherein main active substances are rue
Glucoside.
Citronellol (CAS:106-22-9): having and inhibit golden yellow grape and typhoid bacillus activity, while being a kind of common
Mosquito repellent plant component, but its volatility is high, cannot be used alone, and effect duration is short.
Carbamide peroxide: being decomposed into urea, H2O2 and elemental oxygen in water, and slowly release O2, during pH value of water solution is close
Property, stability is good, and the effectiveness time is long, without side-effects, Nonpoisonous, non-environmental-pollution, and the bactericidal effect to bacterium in air can be improved.
Sodium lignin sulfonate (CAS:8061-51-6) is a kind of surfactant in present component, poly- with the use of shell
Sugar can extend the mosquito repellent time of Icaridin.
Further, the safety and environmental protection mosquito repellent liquid, by following mass fraction at being grouped as: Icaridin 4.5%,
Chitosan 10%, sodium lignin sulfonate 6%, pH buffer 1%, rutin 0.7%, citronellol 0.8%, carbamide peroxide
1.5%, ethyl alcohol 13% and water 62.5%.
Preferably, the pH buffer is salicylic acid or sodium salicylate.
Preferably, the pH buffer is salicylic acid.
The present invention also provides the preparation method of the safety and environmental protection mosquito repellent liquid, step is,
S1: after water and ethyl alcohol are sufficiently mixed, being added chitosan and sodium lignin sulfonate, is heated to 65-75 DEG C, stirring is equal
It is even, obtain mixed liquor A；
S2: being cooled to 40-45 DEG C for the obtained mixed liquor A of step S1, and Icaridin, rutin, citronellol, stirring is added
Uniformly, solution B is obtained；
S3: the obtained solution B of step S2 is down to 25-35 DEG C, carbamide peroxide is added, stirs evenly, then uses pH
Buffer adjust pH to 7.0-8.0 to get.
Compared with prior art, the invention has the following advantages that
1, highly-safe: in mosquito repellent liquid when Icaridin content is more than 5%, to belong to pesticide scope, toxicity is big, the present invention
A variety of safe auxiliary elements are added to, the content of Icaridin can be reduced when guaranteeing the repelling effect of mosquito repellent liquid.
2, bactericidal properties: chitosan and citronellol have good bactericidal effect in the present invention, can inhibit yellow grape ball
The growth of bacterium and Escherichia coli.
3, air cleaning: chitosan has good flocculation, is aided with carbamide peroxide, has to air good net
Change effect.
Specific embodiment
By specific embodiment, the present invention is further illustrated, and those skilled in the art is made more to understand skill of the present invention
Art scheme, but be not the restriction to protection scope.Wherein, present component belongs to conventional products, wherein chitosan (CAS:
9012-76-4): Shandong Xi Tang Biotechnology Co., Ltd.
Embodiment 1
A kind of safety and environmental protection mosquito repellent liquid, by following mass fraction at being grouped as: Icaridin 4.5%, chitosan 10%,
Sodium lignin sulfonate 6%, pH buffer salicylic acid 1%, rutin 0.7%, citronellol 0.8%, carbamide peroxide 1.5%, second
Alcohol 13% and water 62.5%.
The preparation method of the safety and environmental protection mosquito repellent liquid, step be,
S1: after water and ethyl alcohol are sufficiently mixed, being added chitosan and sodium lignin sulfonate, be heated to 70 DEG C, stir evenly,
Obtain mixed liquor A；
S2: being cooled to 43 DEG C for the obtained mixed liquor A of step S1, and Icaridin, rutin, citronellol is added, and stirring is equal
It is even, obtain solution B；
S3: the obtained solution B of step S2 is down to 30 DEG C, carbamide peroxide is added, stirs evenly, is then buffered using pH
Agent bigcatkin willow acid for adjusting pH to 7.5 to get.
Embodiment 2
A kind of safety and environmental protection mosquito repellent liquid, by following mass fraction at being grouped as: Icaridin 5%, chitosan 8%, wood
Quality sodium sulfonate 7%, pH buffer salicylic acid 0.5%, rutin 1%, citronellol 0.5%, carbamide peroxide 2%, ethyl alcohol
11% and water 65%.
The preparation method of the safety and environmental protection mosquito repellent liquid is similar to Example 1.
Embodiment 3
A kind of safety and environmental protection mosquito repellent liquid, by following mass fraction at being grouped as: Icaridin 4%, chitosan 12%, wood
Quality sodium sulfonate 5%, pH buffer sodium salicylate 1.5%, rutin 0.5%, citronellol 1%, carbamide peroxide 1%, ethyl alcohol
15% and water 60%.
The preparation method of the safety and environmental protection mosquito repellent liquid is similar to Example 1.
Comparative example 1
A kind of safety and environmental protection mosquito repellent liquid, by following mass fraction at being grouped as: Icaridin 4.5%, chitosan 10%,
Sodium lignin sulfonate 7.5%, pH buffer salicylic acid 1%, rutin 0.7%, citronellol 0.8%, ethyl alcohol 13% and water
62.5%.
Difference with embodiment 1 is not add carbamide peroxide, increases the content of sodium lignin sulfonate.
The preparation method of the safety and environmental protection mosquito repellent liquid is similar to Example 1.
The test of 1 mosquito repellent of test example
Subjects: embodiment 1-3 and safety and environmental protection mosquito repellent liquid made from comparative example 1.
Test method: taking mosquito repellent liquid 3ml, is uniformly mixed with 1g starch, is encased using cotton, be suspended on 60cm × 45cm ×
The central point of the mosquito cage of 45cm is put into 100 female mosquitos, observes the quantity in different distance mosquito, and counts first mosquito and go out
The time (stopping more than 5 seconds) of present cotton packet, there are 10 thick lines in the vertical and horizontal direction of mosquito cage, provides mosquito foothold, and mosquito is each
Hour changes a batch, and concrete outcome is as shown in the following table 1, table 2, table 3.
Table 1 is put into mosquito repellent data after ten minutes
Mosquito repellent data after table 2 is put into 3 hours
Mosquito repellent data after table 3 is put into 12 hours
As can be seen that the repelling effect of 1-3 of the embodiment of the present invention is reached by 12 hours or more from table 1, table 2 and table 3,
Illustrate that instant component cooperates and be effectively increased the repelling effect of Icaridin, is allowed to reach under low concentration
To preferable repelling effect, and a kind of helper component only is changed in comparative example 1, effect is just changed, and is more illustrated
Compatibility of the invention, and it can also be seen that the cotton after 10 hours of mosquito repellent liquid made from 1-3 of the embodiment of the present invention from table 3
Cloth wraps just first mosquito of appearance, illustrates that the mosquito repellent liquid repelling effect duration disclosed by the invention is long.
2 sterilization test of test example
Subjects: safety and environmental protection mosquito repellent liquid made from embodiment 1-3.
Strain: staphylococcus aureus, Escherichia coli.
Test method: the mosquito repellent liquid of 1ml is mixed with the water of 100ml, stirs evenly, is then mixed and made into agar with agar
Staphylococcus aureus and Escherichia coli are seeded on two culture mediums by culture medium respectively, be put into 37 DEG C of constant temperature incubators into
Row culture 10 hours, observes colony counts, calculates sterilizing rate, and control group is arranged, does not add mosquito repellent liquid, 1- sterilizing rate=clump count
Amount/control group colony counts × 100%.
Concrete outcome is as shown in table 4.
4 sterilizing rate of table
As can be seen from Table 4, mosquito repellent liquid disclosed by the invention has good bactericidal effect, wherein Staphylococcus aureus
Bacterium sterilizing rate has reached 90% or more, and Escherichia coli sterilizing rate has reached 100%.
Claims (4)
1. a kind of mosquito repellent liquid, which is characterized in that by following mass percentage at being grouped as: Icaridin 4.5%, chitosan
10%, sodium lignin sulfonate 6%, pH buffer 1%, rutin 0.7%, citronellol 0.8%, carbamide peroxide 1.5%, ethyl alcohol
13% and water 62.5%.
2. mosquito repellent liquid according to claim 1, which is characterized in that the pH buffer is salicylic acid or sodium salicylate.
3. mosquito repellent liquid according to claim 2, which is characterized in that the pH buffer is salicylic acid.
4. the preparation method of mosquito repellent liquid according to claim 1-3, which is characterized in that step are as follows:
S1: after water and ethyl alcohol are sufficiently mixed by the mass percentage, by the mass percentage be added chitosan with
Sodium lignin sulfonate is heated to 65-75 DEG C, stirs evenly, and obtains mixed liquor A；
S2: being cooled to 40-45 DEG C for the obtained mixed liquor A of step S1, and Icaridin, rue is added by the mass percentage
Glucoside, citronellol, stir evenly, and obtain solution B；
S3: being down to 25-35 DEG C for the obtained solution B of step S2, carbamide peroxide is added by the mass percentage, stirring is equal
It is even, then using pH buffer adjust pH to 7.0-8.0 to get.
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| CN116058369B (en) * | 2022-01-19 | 2024-06-21 | 江苏省疾病预防控制中心(江苏省公共卫生研究院) | Skin disinfection mosquito repellent and preparation method thereof |
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