CN102754651A - Acaricide and application thereof - Google Patents
Acaricide and application thereof Download PDFInfo
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- CN102754651A CN102754651A CN2011101039414A CN201110103941A CN102754651A CN 102754651 A CN102754651 A CN 102754651A CN 2011101039414 A CN2011101039414 A CN 2011101039414A CN 201110103941 A CN201110103941 A CN 201110103941A CN 102754651 A CN102754651 A CN 102754651A
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- Prior art keywords
- miticide
- agent
- mite
- goes out
- ivermectin
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- 239000000642 acaricide Substances 0.000 title claims abstract description 106
- 230000000895 acaricidal effect Effects 0.000 title claims abstract description 18
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims abstract description 32
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- 238000009472 formulation Methods 0.000 claims abstract description 22
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims description 130
- 239000003795 chemical substances by application Substances 0.000 claims description 60
- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 claims description 20
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- 239000000375 suspending agent Substances 0.000 claims description 19
- CGQCWMIAEPEHNQ-UHFFFAOYSA-N Vanillylmandelic acid Chemical compound COC1=CC(C(O)C(O)=O)=CC=C1O CGQCWMIAEPEHNQ-UHFFFAOYSA-N 0.000 claims description 18
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides an acaricide comprising effective components of: acequinocyl, and at least one selected from abamectin, ivermectin, methylamino abamectin benzoate, and milbemectin. A mass ratio of the at least one selected from abamectin, ivermectin, methylamino abamectin benzoate, and milbemectin to acequinocyl is 50:1-1:50. According to the invention, through the formulation of the effective components, a synergetic effect of the acaricide is effectively improved, and a controlling effect of the acaricide against target pest mites is substantially improved. Because the acaricide has an excellent synergetic effect, the potency of the acaricide is improved, field dosage of the acaricide is reduced, pesticide residue and harm to beneficial living things are effectively reduced; and controlling cost and environment pollution are reduced. According to the invention, action mechanisms of the effective components of the acaricide are fully utilized, such that a synergetic effect is achieved by using the two components, and drug resistance of the pest mites can be effectively retarded or overcome.
Description
Technical field
The invention belongs to the pesticidal preparations field, relate in particular to a kind of miticide and application thereof.
Background technology
The mite class belongs to the Arthropoda arachnids.Phytophagous mites mainly contains tetranychid, Panonychus citri, goitre mite, rust mite etc., is a kind of common insect, danger to vegetables, and fruit tree, crops such as cotton are often caused destructive disaster.Important harmful mite on the agricultural is because its breeding cycle is short, and breeding amount is big, and mobility is little, and the selfing degree is high, is easy to generate pesticide resistance especially.
At present, to the control more and more difficult of Arthropoda insect.Mainly be because of the drug resistance of insect, and insecticide concentration increase the influence to environment that is caused to used insecticide.For avoiding influence, must reduce the consumption of pest control with insecticide chaste tree, yet the insecticide of use low concentration has promoted the increase of insect resistance kind, in addition, can not guarantee whole kill pests and destroy its growth cycle to environment.For avoiding above-mentioned deficiency, need find the agricultural chemicals of Pest Control, particularly acarid.
Meanwhile, the insecticide of existing Arthropoda pest type particularly macrolide antibiotics existence is responsive to light, and the field longevity of residure is not long, defectives such as use cost height.
Summary of the invention
In view of this, need provide a kind of synergistic effect remarkable, control efficiency is good, the miticide that drug cost is low.
And, the application of a kind of miticide in preventing and treating phytophagy evil mite is provided.
The present invention solves the problems of the technologies described above the technical scheme that is adopted:
A kind of miticide; Comprise active principle AVM, ivermectin, emamectin-benzoate, more visit at least a and mite quinone that goes out in the rhzomorph, said AVM, ivermectin, emamectin-benzoate, the mass ratio of more visiing total amount at least a in the rhzomorph and the mite quinone that goes out are 50: 1～1: 50.
And, the application of above-mentioned miticide in preventing and treating phytophagy evil mite.
Above-mentioned miticide is used to prevent and treat Panonychus citri, Tetranychus cinnabarinus or/and Tetranychus urticae.
Above-mentioned miticide possesses following advantage at least:
This miticide through to AVM, ivermectin, emamectin-benzoate, more visit in the rhzomorph at least a and mite quinone component of going out and join mutually; Effectively improved this acaricidal synergistic effect; Obviously improve the control efficiency of this miticide to target evil mite, concrete for example referring to data in table 1 to the table 9.
2. because this miticide has good synergistic effect, thereby improved this miticide drug effect, reduced this acaricidal field dosage, can effectively reduce residue of pesticide and, reduce the control cost simultaneously and alleviate pollution environment to the harm of beneficial organism.
3. make full use of AVM, ivermectin, emamectin-benzoate, more visit the mechanism of action separately of at least a and mite quinone component of going out in the rhzomorph; Make two kinds of components act synergistically, thereby make this miticide can effectively delay or overcome the pesticide resistance of harmful mite.
Embodiment
In order to make the object of the invention, technical scheme and advantage clearer,, the present invention is further elaborated below in conjunction with embodiment.Should be appreciated that specific embodiment described herein only in order to explanation the present invention, and be not used in qualification the present invention.
A kind of synergistic effect that the embodiment of the invention provides is remarkable, and control efficiency is good, the miticide that drug cost is low.This miticide comprises active principle AVM, ivermectin, emamectin-benzoate, more visits at least a and mite quinone that goes out in the rhzomorph; Wherein, AVM, ivermectin, emamectin-benzoate, the mass ratio of more visiing total amount at least a in the rhzomorph and the mite quinone that goes out are 50: 1～1: 50.
Particularly, the mite quinone of being mentioned in the foregoing description (Acequinocyl) that goes out, chemical name: 2-(acetoxyl group) 3-dodecyl-1; The 4-naphthoquinones; Mainly act on the respiratory muscle system of mite class, make its respiratory paralysis, finally cause its hypoxia death; The mite quinone that goes out has quick knockdown effect, no systemic action.
The AVM of being mentioned in the foregoing description, ivermectin, emamectin-benzoate and Mi Bai rhzomorph belong to macrolides compound.This macrolides compound is meant the big ring-type bioactivator with lactone bond of microorganisms, comprises the big molecule antibiotic that macrolide group and sugar derivatives link to each other and form with glycosidic bond.
Preferably, as one embodiment of the present of invention, the AVM in the above-mentioned miticide, ivermectin, emamectin-benzoate, the mass ratio of more visiing total amount at least a in the rhzomorph and the mite quinone that goes out are 20: 1～1: 20.This preferred content specific energy further improves the acaricidal virulence effect of the present invention, strengthens this acaricidal synergistic effect., all have significant synergies all greater than 180 like the prepared acaricidal CTC of embodiment in embodiment 28 to embodiment 33, the table 9 in embodiment 18 to embodiment 23, the table 8 in embodiment in the below table 68 to embodiment 13, the table 7 38 to embodiment 43.
Preferably, as one embodiment of the invention, AVM, ivermectin, emamectin-benzoate, more visit total amount at least a in the rhzomorph and account for 1～20% of miticide gross mass; The mite quinone that goes out accounts for 0.1～10% of miticide gross mass.The miticide of this concentration range can effectively improve the dispersive property and this acaricidal stability of raising of the active principle in the miticide.Further guarantee simultaneously the go out drug effect of mite agent of the embodiment of the invention, conveniently implement and reduce use cost, the go out consumption of mite agent of the suitable reduction embodiment of the invention.
Further, above-mentioned miticide also comprises the auxiliary agent of 20～70wt% and the filler of 0～90wt%.
Particularly, auxiliary agent is preferably dispersant, antifreezing agent, thickener, antifoaming agent, wetting agent, disintegrant, emulsifier, stabilizing agent, cosolvent, curing agent, solvent, sticker, wet spreader, synergist, anti-ly separates at least a in agent, the antimicrobial; Filler is preferably that kaolin, diatomite, potter's clay, clay, talcum powder, pyrophillite, tea are withered, at least a in the precipitated calcium carbonate, white carbon.
Wherein, dispersant preferably accounts for 5～20% of embodiment of the invention miticide gross mass, and its kind preferably but not only be merely sodium lignin sulfonate, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate (NNO), draw back at least a in the powder; Antifreezing agent content preferably accounts for 1～5% of embodiment of the invention miticide gross mass, and its kind preferably but not only be merely ethylene glycol; Amount of thickener preferably accounts for 1～5% of embodiment of the invention miticide gross mass, and its kind preferably but not only be merely at least a in bentonite, gum Arabic, the xanthans; Antifoam content preferably accounts for 0.1～0.8% of embodiment of the invention miticide gross mass, and its kind preferably but not only be merely silicone oil; Stabiliser content preferably accounts for 2～15% of embodiment of the invention miticide gross mass, and its kind can be a present technique field stabilizing agent commonly used; Emulsifier content preferably accounts for 3～30% of embodiment of the invention miticide gross mass, and its kind preferably but not only be merely at least a in calcium dodecyl benzene sulfonate, phenethyl phenol polyethenoxy ether, the triphen ethyl-phenol polyoxyethylene; Antimicrobial agent content preferably accounts for 0.1～1% of embodiment of the invention miticide gross mass, and its kind can be a present technique field stabilizing agent commonly used; Cosolvent content preferably accounts for 5～20% of embodiment of the invention miticide gross mass, and its kind preferably but not only be merely N-Methyl pyrrolidone; Synergist content preferably accounts for 1～5% of embodiment of the invention miticide gross mass, and its kind can be a present technique field synergist commonly used, like stabilizing agent etc., stabilizing agent can but be not only epoxychloropropane; Solvent preferably accounts for 5～15% of embodiment of the invention miticide gross mass, its kind can but be not only at least a in ring ethyl ketone, ethylene glycol, the xylol; Curing agent preferably but not only be merely polyisocyanates; Wetting agent preferably but not only be merely lauryl sodium sulfate and/or sodium lignin sulfonate; Disintegrant preferably but not only be merely Magnesiumaluminumsilicate, sticker, wet spreader, the anti-agent kind of separating can be that the present technique field is commonly used.Certainly, above-mentioned auxiliary agent and filler can also be other types and the auxiliary agent and the filler of/function.
The auxiliary agent of mentioned kind and content and/or filler can further strengthen the drug effect of active principle of the present invention; Make miticide on target, have good adhesive rate and good permeability and the anti-drift of opening up; Can significantly promote adhesion and the retention performance of this miticide on plant corpus and target, reduce medicament and run off, increase bioavailability; Reduce amount of application and use cost, reduce environmental pollution.
Particularly, above-mentioned acaricidal formulation is preferably suspending agent, oil-suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion, missible oil or micro-capsule suspension.Embodiment of the invention miticide can dispose this preferred formulation flexibly according to concrete phytophagy evil mite and agriculture production environment through suitable adjustment carrier, auxiliary agent and/or filler.
Embodiment of the invention miticide is except comprising above-mentioned active principle; Perhaps comprise outside above-mentioned active principle and auxiliary agent and/or the filler; Also comprise the carrier that miticide is used; This carrier can be according to different miticide formulations and select flexibly, and during like the miticide of preparation suspending agent and micro emulsion formulation, carrier can be chosen deionized water; Make up oil when hanging the miticide of formulation, carrier can be chosen refined soybean oil; When preparing the miticide of aqueous dispersion formulation, carrier can be chosen diatomite; When preparing the miticide of wettable powder formulation, carrier can be chosen kaolin.Certainly, carrier can also be other kind of carrier commonly used of this area.
Therefore, to sum up state saidly, the prescription of embodiment of the invention miticide one preferred weight percent is:
The suspending agent type miticide:
Wherein, effective constituents A is the mite quinone that goes out, active ingredient B be AVM, ivermectin, emamectin-benzoate, more visit in the rhzomorph at least a.
The prescription of another preferred weight percent of embodiment of the invention miticide is:
Missible oil formulation miticide:
Wherein, effective constituents A is the mite quinone that goes out, active ingredient B be AVM, ivermectin, emamectin-benzoate, more visit in the rhzomorph at least a.
The prescription of the another preferred weight percent of embodiment of the invention miticide is:
Micro emulsion formulation miticide:
Wherein, effective constituents A is the mite quinone that goes out, active ingredient B be AVM, ivermectin, emamectin-benzoate, more visit in the rhzomorph at least a.
The prescription of the 4th kind of preferred weight percent of embodiment of the invention miticide is: micro-capsule suspension type miticide:
Wherein, effective constituents A is the mite quinone that goes out, active ingredient B be AVM, ivermectin, emamectin-benzoate, more visit in the rhzomorph at least a.
The prescription of the 5th kind of preferred weight percent of embodiment of the invention miticide is:
Water and milk formulation miticide:
Wherein, effective constituents A is the mite quinone that goes out, active ingredient B be AVM, ivermectin, emamectin-benzoate, more visit in the rhzomorph at least a.
Foregoing invention embodiment miticide has effectively improved this acaricidal synergistic effect through to the joining mutually of active principle, obviously improves the control efficiency of this miticide to target evil mite, specifically referring to data in table 1 to the table 9; Because this miticide has good synergistic effect, thereby improved this miticide drug effect, reduced this acaricidal field dosage, can effectively reduce residue of pesticide and, reduce the control cost simultaneously and alleviate pollution environment to the harm of beneficial organism.This miticide makes full use of the mechanism of action separately of at least two kinds of above-mentioned components, makes two kinds of components act synergistically, thereby makes this miticide can effectively delay or overcome the pesticide resistance of harmful mite.
The miticide that provides just because of the embodiment of the invention has above-mentioned excellent properties, and therefore, this miticide can be used for preventing and treating phytophagy evil mite.
Preferably, above-mentioned miticide can be used to prevent and treat Panonychus citri, Tetranychus cinnabarinus or/and Tetranychus urticae.
When above-mentioned miticide was used to prevent and treat phytophagy evil mite, the assay method of this miticide virulence was following:
Supply the examination object: phytophagy evil mite, like Tetranychus urticae (Tetranychus urticae Koch).Pick up from the Guanlan, Shenzhen City, Guangdong Province, indoor black nightshade seedling raised for two generations.
Test medicine: the 96.8% former medicine of mite quinone (Ai Lisida company) that goes out; The former medicine of 96.6% AVM (Qianjiang Biochemistry Co., Ltd., Zhejiang Prov.); The former medicine of 99% ivermectin (Hebei Weiyuan biochemistry Co Co., Ltd); The 70% first dimension former medicine of salt (woods chemicals Co., Ltd of Nantong section); 95% more visits the former medicine of rhzomorph (Nanjing Yibeijia Technology Co., Ltd.), and contains the active ingredient AVM, ivermectin, emamectin-benzoate of different quality ratio, more visits the embodiment of the invention miticide medicament of at least a and mite quinone that goes out in the rhzomorph.
Test method: adopt potted plant spray-on process.Choose health, no damage by disease and insect, the free of contamination fresh kidney beans seedling of plantation in the greenhouse, the phytophagy evil mite adult that breeds in the inoculation greenhouse, 30 of every strains become mite; Treat that mite pushes up end spraying with the fresh kidney beans seedling after stable on the plant under spray tower; Level pressure (0.4MPA), blank is handled in quantitatively spraying (every processing 10mL soup) earlier; Repeat aforesaid operations by experimental scheme dosage order from low to high then; 5 concentration gradients are done in each proportioning or single agent, and each concentration gradient is provided with 4 repetitions, and each repeats 1 basin fresh kidney beans seedling.Treat that surperficial soup natural air drying places 25 ± 1 ℃, L: D=10 behind the spray medicine: 14 illumination conditions recover, observe down; Check under stereomicroscope behind the 10d and live that touch the examination worm with toothpick, the person of creeping is mite alive, calculate insect population go down rate and preventive effect into the mite number.
The method of passing through toxicity index calculating mixture co-toxicity that the judgement of miticide virulence of the present invention adopts Sun Yunpei to equal the nineteen sixty proposition is co-toxicity coefficient (CTC) method.The computing formula of co-toxicity coefficient is following:
Actual measurement toxicity index (ATI)=(standard medicament LC
50/ confession reagent agent LC
50) * 100;
The percentage composition of B in percentage composition+B medicament ATI * mixture of A in theoretical toxicity index (TTI)=A medicament ATI * mixture;
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100.
When CTC≤80, then miticide shows as antagonism, and when 80＜CTC＜120, then miticide shows as summation action, and when CTC>=120, then miticide shows as synergistic effect.
Below further through a plurality of embodiment illustrate that the invention described above embodiment miticide different is formed, preparation with and aspect such as performance.
Embodiment 1
Mite agent prescription: the 96.8wt% that goes out of the suspending agent type former medicine 20.66g of mite quinone that goes out, the former medicine 2.07g of 96.6wt% AVM, sodium lignin sulfonate (dispersant) 4g; Ethylene glycol (antifreeze) 4g; Bentonite (thickener) 3g, silicone oil (antifoaming agent) 0.4g, deionized water is mended to 100g.In this mite agent prescription that goes out, the mite quinone AVM suspending agent content that goes out is 22wt%, and wherein, the mass ratio of go out mite quinone and AVM is 10: 1.
The present embodiment suspending agent type mite agent compounding method that goes out: go out mite quinone and each component such as AVM, dispersant, antifreeze, thickener, antifoaming agent and water carrier of active ingredient are even by the mixed of above-mentioned prescription; After sand milling and/or high speed shear, make suspending agent.
Comparative trial 1
Obtain the 15wt% 22wt% of mite quinone suspending agent, 1.8wt% abamectin emulsifiable concentrate, the embodiment 1 preparation mite quinone AVM suspending agent that goes out that goes out respectively.
Above-mentioned 3 kinds of medicament miticides are carried out the mensuration of virulence, the assay method of assay method such as above-mentioned virulence.These 3 kinds of miticides are diluted spraying by the metering in the below table 1, be used for the panonychus citri control.After the dispenser 7 days, the preventive effect of 3 medicaments was respectively 84.6%, 77.4% and 98.2%, has synergistic effect; After the dispenser 21 days; Preventive effect is respectively 69.6%, 53.2% and 88.7%, and difference on effect is obvious, and the single relatively agent of lasting effect that illustrative embodiment 1 prepares the mite agent of going out obviously strengthens.
Table 1 present embodiment is to the field control effect of panonychus citri
Embodiment 2
Mite agent prescription: the 96.8wt% that goes out of the missible oil formulation former medicine 10.33g of mite quinone that goes out; The former medicine 2.86g of 70wt% first dimension salt; N-Methyl pyrrolidone (cosolvent) 10g, epoxychloropropane (stabilizing agent) 3g, calcium dodecyl benzene sulfonate (emulsifier) 5g; Phenethyl phenol polyethenoxy ether (emulsifier) 5g, turpentine oil complements to 100g.This emulsifiable concentrate content that goes out mite quinone first dimension salt missible oil is 12wt%, and wherein, the mass ratio of mite quinone and the first of going out dimension salt missible oil is 5: 1.
The present embodiment missible oil formulation mite agent compounding method that goes out: go out mite quinone and components such as first dimension salt missible oil, emulsifier and cosolvent of active ingredient are added mixing kettle successively by formula rate, stir, promptly get the mite agent of going out of missible oil formulation.
Comparative trial 2
Obtain 15wt% the go out emulsifiable concentrate of mite quinone first dimension salt missible oil of the 12wt% of mite quinone suspending agent, 5wt% first dimension salt missible oil, embodiment 2 preparations that goes out respectively.
Above-mentioned 3 kinds of medicament miticides are carried out the mensuration of virulence, the assay method of assay method such as above-mentioned virulence.These 3 kinds of miticides are diluted spraying by the metering in the below table 2, be used for the control of strawberry Tetranychus urticae.After the dispenser 7 days, the preventive effect of 3 medicaments was respectively 81.6%, 76.5% and 93.5%, has synergistic effect; After the dispenser 15 days; Preventive effect is respectively 71.4%, 48.4% and 81.8%, and difference on effect is obvious, and the single relatively agent of lasting effect that illustrative embodiment 2 prepares the mite agent of going out obviously strengthens.
Table 2 present embodiment is to the field control effect of strawberry Tetranychus urticae
Embodiment 3
The 96.8wt% former medicine 1.03g of mite quinone that goes out; The former medicine 2.07g of 96.6wt% AVM; N-Methyl pyrrolidone (cosolvent) 10g, calcium dodecyl benzene sulfonate (emulsifier) 8g, phenethyl phenol polyethenoxy ether (emulsifier) 7g; Triphen ethyl-phenol polyoxyethylene (emulsifier) 5g, deionized water (carrier) complements to 100g.In this mite agent prescription that goes out, the mite quinone avermectin micro-emulsion content that goes out is 3wt%, and wherein, the mass ratio of go out mite quinone and AVM is 1: 2.
The present embodiment missible oil formulation mite agent compounding method that goes out: former medicine, cosolvent, emulsifier are added together, make and be dissolved into even oil phase, stir down and slowly adds in the entry,, make microemulsion after being chilled to room temperature again through the rapid phase inversion of agitating heating.
Comparative trial 3
Obtain the 15wt% 3wt% of mite quinone suspending agent, 1.8% abamectin emulsifiable concentrate, the embodiment 3 preparations mite quinone avermectin micro-emulsion that goes out that goes out respectively.
Above-mentioned 3 kinds of medicament miticides are carried out the mensuration of virulence, the assay method of assay method such as above-mentioned virulence.These 3 kinds of miticides are diluted spraying by the metering in the below table 3, be used for the panonychus citri control.After the dispenser 7 days, the preventive effect of 3 medicaments was respectively 80.3%, 74.8% and 94.6%, has synergistic effect.After the dispenser 21 days, preventive effect was respectively 65.1%, 55.2% and 85.4%, and difference on effect is obvious, and the go out single relatively agent of lasting effect of mite agent of illustrative embodiment 3 preparations obviously strengthens.
Table 3 present embodiment is to the field control effect of panonychus citri
Embodiment 4
The 96.8wt% former medicine 5.17g of mite quinone that goes out, the former medicine 1.01g of 99wt% ivermectin, cyclohexanone (solvent) 1g, polyisocyanates (curing agent) 0.4g, ethylene glycol (solvent) 0.4g, gum Arabic (thickener) 1g, deionized water (carrier) complements to 100g.In this mite agent prescription that goes out, the mite quinone ivermectin micro-capsule suspension content that goes out is 6wt%, and wherein, the mass ratio of go out mite quinone and ivermectin is 5: 1.
The present embodiment microcapsules missible oil formulation mite agent compounding method that goes out: adopt interfacial polymerization; With directly being scattered in the gum Arabic aqueous solution after former medicine, polyisocyanates and the cyclohexanone mixing; Add polyalcohol then, slow reaction is processed capsule, forms microcapsule suspending agent.
Comparative trial 4
Obtain the 15wt% 6wt% of mite quinone suspending agent, 1.8wt% ivermectin missible oil, the embodiment 4 preparations mite quinone ivermectin micro-capsule suspension that goes out that goes out respectively.
Above-mentioned 3 kinds of medicament miticides are carried out the mensuration of virulence, the assay method of assay method such as above-mentioned virulence.These 3 kinds of miticides are diluted spraying by the metering in the below table 4, be used for the control of tomato red spider.After the dispenser 7 days, the preventive effect of 3 medicaments was respectively 82.3%, 78.4% and 92.1%, has synergistic effect.After the dispenser 21 days, preventive effect was respectively 64.1%, 58.3% and 87.6%, and difference on effect is obvious, and the go out single relatively agent of lasting effect of mite agent of illustrative embodiment 4 preparations obviously strengthens.
Table 4 present embodiment is to the field control effect of panonychus citri
Embodiment 5
The 96.8wt% former medicine 3.10g of mite quinone that goes out; 95wt% more visits the former medicine 1.05g of rhzomorph, calcium dodecyl benzene sulfonate (emulsifier) 2.1g, phenethyl phenol polyethenoxy ether (emulsifier) 1.5g; Cyclohexanone (solvent) 10.1g; Xylol (solvent) 10.2g, xanthans (thickener) 0.5g, deionized water (carrier) complements to 100g.In this mite agent prescription that goes out, it is 4wt% that the mite quinone that goes out is more visitd rhzomorph aqueous emulsion content, and wherein, the mass ratio of go out mite quinone and ivermectin is 3: 1.
The present embodiment water and milk formulation mite agent compounding method that goes out: former medicine, solvent, emulsifier etc. are fully mixed stirring and dissolving in proportion process oil phase; Under constantly stirring; Antifreezing agent, water, thickener are fully stirred into water, water is directly added in the oil phase, stir and make aqueous emulsion.
Comparative trial 5
Obtain 15wt% 4wt% that mite quinone suspending agent, 2.5wt% more visit rhzomorph aqueous emulsion, the embodiment 5 preparations mite quinone that goes out that goes out respectively and more visit the rhzomorph aqueous emulsion.
Above-mentioned 3 kinds of medicament miticides are carried out the mensuration of virulence, the assay method of assay method such as above-mentioned virulence.These 3 kinds of miticides are diluted spraying by the metering in the below table 5, be used for the panonychus citri control.After the dispenser 7 days, the preventive effect of 3 medicaments was respectively 86.9%, 82.6% and 95.7%, has synergistic effect.After the dispenser 21 days, preventive effect was respectively 71.3%, 53.2% and 83.4%, and difference on effect is obvious, and the go out single relatively agent of lasting effect of mite agent of illustrative embodiment 5 preparations obviously strengthens.
Table 5 present embodiment is to the field control effect of panonychus citri
Embodiment 6 to embodiment 15
The prescription of embodiment 6 to embodiment 15 is as go out the mite agent prescription and the preparation method of suspending agent type among the embodiment 1, and the difference contained mass ratio of mite quinone and AVM that is to go out is different, and is concrete referring to below table 6.
Comparative trial 6 to comparative trial 7
Obtain the 96.8wt% former medicine of mite quinone that goes out respectively, the mite agent of going out of the suspending agent type of former medicine of 96.6wt% AVM and embodiment 6 to embodiment 15 preparations.
Above-mentioned 12 kinds of medicament miticides are carried out the mensuration of virulence, the assay method of assay method such as above-mentioned virulence.Concrete grammar is: these 12 kinds of medicament miticides are adopted potted plant spray-on process; Choose health, no damage by disease and insect, the free of contamination fresh kidney beans seedling of plantation in the greenhouse, the Tetranychus urticae adult that breeds in the inoculation greenhouse, 30 of every strains become mite; Treat that mite pushes up end spraying with the fresh kidney beans seedling after stable on the plant under spray tower; Level pressure (0.4MPA), blank is handled in quantitatively spraying (every processing 10mL soup) earlier; Repeat aforesaid operations by experimental scheme dosage order from low to high then; 5 concentration gradients are done in each proportioning or single agent, and each concentration gradient is provided with 4 repetitions, and each repeats 1 basin fresh kidney beans seedling.Treat that surperficial soup natural air drying places 25 ± 1 ℃, L: D=10 behind the spray medicine: 14 illumination conditions recover, observe down; Check under stereomicroscope behind the 10d and live that touch the examination worm with toothpick, the person of creeping is mite alive, calculate insect population go down rate and preventive effect into the mite number.Above-mentioned 12 kinds of medicament miticides carry out the mensuration such as the below table 6 of virulence.
Go out mite quinone and AVM different proportion of table 6 goes out mite agent and comparative trial to the Tetranychus urticae joint toxicity measuring
The result of the mite agent virulence of from the foregoing description 6 to embodiment 15 and comparative trial 6 to comparative trial 7, going out test shows; The embodiment of the invention go out the mite agent in the mass ratio of go out mite quinone and AVM is 50: 1～1: 50 ratio range to the co-toxicity coefficient CTC of strawberry Tetranychus urticae joint toxicity measuring all greater than 120, have synergistic effect.Especially in 20: 1～1: 20 ratio range, CTC is all greater than 180, and synergistic effect is remarkable.
Embodiment 16 to embodiment 25
The prescription of embodiment 16 to embodiment 25 is as go out the mite agent prescription and the preparation method of micro-capsule suspension type among the embodiment 4, and the difference contained mass ratio of mite quinone and AVM that is to go out is different, and is concrete referring to below table 7.
Comparative trial 8 to comparative trial 9
Obtain the 96.8wt% former medicine of mite quinone that goes out respectively, the mite agent of going out of the micro-capsule suspension type of former medicine of 99wt% ivermectin missible oil and embodiment 16 to embodiment 25 preparations.
Above-mentioned 12 kinds of medicament miticides are carried out the mensuration of virulence, and assay method is referring to the toxicity test method of embodiment 6 to embodiment 15.Above-mentioned 12 kinds of medicament miticides carry out the mensuration such as the below table 7 of virulence.
Go out mite quinone and ivermectin different proportion of table 7 goes out mite agent and comparative trial to the Tetranychus urticae joint toxicity measuring
The result of the mite agent virulence of from the foregoing description 16 to embodiment 25 and comparative trial 8 to comparative trial 9, going out test shows; The embodiment of the invention go out the mite agent in the mass ratio of go out mite quinone and ivermectin is 50: 1～1: 50 ratio range to the co-toxicity coefficient CTC of strawberry Tetranychus urticae joint toxicity measuring all greater than 120, have synergistic effect.Especially in 20: 1～1: 20 ratio range, CTC is all greater than 180, and synergistic effect is remarkable.
Embodiment 26 to embodiment 35
The prescription of embodiment 26 to embodiment 35 is as go out the mite agent prescription and the preparation method of missible oil formulation among the embodiment 2, and the difference contained mass ratio of mite quinone and first dimension salt that is to go out is different, and is concrete referring to below table 8.
Comparative trial 10 to comparative trial 11
Obtain the 96.8wt% former medicine of mite quinone that goes out respectively, the mite agent of going out of the missible oil formulation that the 70wt% first dimension former medicine of salt and embodiment 26 to embodiment 35 prepare.
Above-mentioned 12 kinds of medicament miticides are carried out the mensuration of virulence, and assay method is referring to the toxicity test method of embodiment 6 to embodiment 15.Above-mentioned 12 kinds of medicament miticides carry out the mensuration such as the below table 8 of virulence.
Table 8 mite quinone and the first dimension salt different proportion that goes out goes out mite agent and comparative trial to the Tetranychus urticae joint toxicity measuring
The result of the mite agent virulence of from the foregoing description 26 to embodiment 35 and comparative trial 10 to comparative trial 11, going out test shows; The embodiment of the invention go out the mite agent the mass ratio of mite quinone and the first dimension salt that goes out be in 50: 1～1: 50 the ratio range to the co-toxicity coefficient CTC of strawberry Tetranychus urticae joint toxicity measuring all greater than 120, have synergistic effect.Especially in 20: 1～1: 20 ratio range, CTC is all greater than 180, and synergistic effect is remarkable.
Embodiment 36 to embodiment 45
The prescription of embodiment 36 to embodiment 45 is as go out the mite agent prescription and the preparation method of water and milk formulation among the embodiment 5, and the difference contained mass ratio of mite quinone and Mi Bai rhzomorph that is to go out is different, and is concrete referring to below table 9.
Comparative trial 12 to comparative trial 13
Obtain the 96.8wt% former medicine of mite quinone that goes out respectively, 99wt% more visits the mite agent of going out of the water and milk formulation of former medicine of rhzomorph and embodiment 36 to embodiment 45 preparations.
Above-mentioned 12 kinds of medicament miticides are carried out the mensuration of virulence, and assay method is referring to the toxicity test method of embodiment 6 to embodiment 15, wherein, and the Tetranychus cinnabarinus adult that breeds in the inoculation greenhouse.Above-mentioned 12 kinds of medicament miticides carry out the mensuration such as the below table 9 of virulence.
Go out mite quinone and Mi Bai rhzomorph different proportion of table 9 goes out mite agent and comparative trial to the Tetranychus cinnabarinus joint toxicity measuring
The result of the mite agent virulence of from the foregoing description 36 to embodiment 45 and comparative trial 12 to comparative trial 13, going out test shows; The embodiment of the invention go out the mite agent in go out mite quinone and the mass ratio of more visiing rhzomorph are 50: 1～1: 50 ratio range to the co-toxicity coefficient CTC of Tetranychus cinnabarinus joint toxicity measuring all greater than 120, have synergistic effect.Especially in 20: 1～1: 20 ratio range, CTC is all greater than 180, and synergistic effect is remarkable.
Can find out from the foregoing description 1 to embodiment 45 and comparative trial 1 to comparative trial 13; The embodiment of the invention is gone out the mite agent to phytophagy evil mite class; Especially phytophagy such as panonychus citri, strawberry Tetranychus urticae, Tetranychus cinnabarinus evil mite class there is good control efficiency; Has obvious synergistic effect; Relatively AVM, ivermectin, emamectin-benzoate, more visit rhzomorph or the mite quinone list agent control efficiency of going out obviously improves, can reduce the field rotating medicine number of times of dosage simultaneously, delay evil mite pesticide resistance and produce.Lasting period prolongs, and can reduce the medication number of times, reduces the control cost.
The above is merely preferred embodiment of the present invention, not in order to restriction the present invention, all any modifications of within spirit of the present invention and principle, being done, is equal to and replaces and improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. miticide; Comprise active principle AVM, ivermectin, emamectin-benzoate, more visit at least a and mite quinone that goes out in the rhzomorph, said AVM, ivermectin, emamectin-benzoate, the mass ratio of more visiing total amount at least a in the rhzomorph and the mite quinone that goes out are 50: 1～1: 50.
2. miticide according to claim 1 is characterized in that: said AVM, ivermectin, emamectin-benzoate, the mass ratio of more visiing total amount at least a in the rhzomorph and the mite quinone that goes out are 20: 1～1: 20.
3. miticide according to claim 1 is characterized in that: said AVM, ivermectin, emamectin-benzoate, more visit total amount at least a in the rhzomorph and account for 1～20% of miticide gross mass; The said mite quinone that goes out accounts for 0.1～10% of miticide gross mass.
4. miticide according to claim 1 is characterized in that: also comprise the auxiliary agent of 20～70wt% and the filler of 0～90wt%.
5. miticide according to claim 4 is characterized in that: said auxiliary agent is dispersant, antifreezing agent, thickener, antifoaming agent, wetting agent, disintegrant, emulsifier, stabilizing agent, cosolvent, curing agent, solvent, sticker, wet spreader, synergist, anti-ly separates at least a in agent, the antimicrobial.
6. miticide according to claim 4 is characterized in that: said filler is that kaolin, diatomite, potter's clay, clay, talcum powder, pyrophillite, tea are withered, at least a in the precipitated calcium carbonate, white carbon.
7. according to the arbitrary described miticide of claim 1～6, it is characterized in that: said acaricidal formulation is suspending agent, oil-suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion, missible oil or micro-capsule suspension.
8. be used to prevent and treat phytophagy evil mite according to the arbitrary described miticide of claim 1～6.
9. be used to prevent and treat Panonychus citri, Tetranychus cinnabarinus or/and Tetranychus urticae according to the arbitrary described miticide of claim 1～6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110103941.4A CN102754651B (en) | 2011-04-25 | 2011-04-25 | Acaricide and application thereof |
Applications Claiming Priority (1)
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103503906A (en) * | 2012-06-28 | 2014-01-15 | 陕西美邦农药有限公司 | Efficient pesticide composition containing acequinocyl |
| CN106359440A (en) * | 2016-08-26 | 2017-02-01 | 江苏克胜作物科技有限公司 | Dinotefuran dispersible oil suspension agent and preparation method thereof |
| CN107318862A (en) * | 2016-04-28 | 2017-11-07 | 江苏龙灯化学有限公司 | A kind of Pesticidal combination |
| CN109221254A (en) * | 2018-08-21 | 2019-01-18 | 西南大学 | A kind of miticide composition and its application derived from oriental moth |
| CN112155011A (en) * | 2020-09-17 | 2021-01-01 | 惠州市银农科技股份有限公司 | Emamectin benzoate microcapsule suspending agent and preparation method thereof |
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| JPS50155620A (en) * | 1974-05-10 | 1975-12-16 | ||
| US20100204167A1 (en) * | 2006-07-11 | 2010-08-12 | Reiner Fischer | Active compound combinations having insecticidal and acaricidal properties |
| CN101933518A (en) * | 2003-11-14 | 2011-01-05 | 拜尔农作物科学股份公司 | Active agent combinations with insecticidal and acaricidal properties |
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| JPS50155620A (en) * | 1974-05-10 | 1975-12-16 | ||
| CN101933518A (en) * | 2003-11-14 | 2011-01-05 | 拜尔农作物科学股份公司 | Active agent combinations with insecticidal and acaricidal properties |
| US20100204167A1 (en) * | 2006-07-11 | 2010-08-12 | Reiner Fischer | Active compound combinations having insecticidal and acaricidal properties |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103503906A (en) * | 2012-06-28 | 2014-01-15 | 陕西美邦农药有限公司 | Efficient pesticide composition containing acequinocyl |
| CN103503906B (en) * | 2012-06-28 | 2017-02-15 | 青岛金尔农化研制开发有限公司 | Efficient pesticide composition containing acequinocyl |
| CN107318862A (en) * | 2016-04-28 | 2017-11-07 | 江苏龙灯化学有限公司 | A kind of Pesticidal combination |
| CN106359440A (en) * | 2016-08-26 | 2017-02-01 | 江苏克胜作物科技有限公司 | Dinotefuran dispersible oil suspension agent and preparation method thereof |
| CN109221254A (en) * | 2018-08-21 | 2019-01-18 | 西南大学 | A kind of miticide composition and its application derived from oriental moth |
| CN109221254B (en) * | 2018-08-21 | 2021-01-26 | 西南大学 | Mite-killing composition derived from yellow-thorn moth and application thereof |
| CN112155011A (en) * | 2020-09-17 | 2021-01-01 | 惠州市银农科技股份有限公司 | Emamectin benzoate microcapsule suspending agent and preparation method thereof |
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| CN102754651B (en) | 2015-01-14 |
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