CN113826627A

CN113826627A - Insecticidal composition containing flonicamid and pyrethroids and application

Info

Publication number: CN113826627A
Application number: CN202010578760.6A
Authority: CN
Inventors: 姚志牛; 潘利东
Original assignee: Jiangsu Work Is At Bio Tech Ltd
Current assignee: Jiangsu Work Is At Bio Tech Ltd
Priority date: 2020-06-23
Filing date: 2020-06-23
Publication date: 2021-12-24

Abstract

The invention relates to a sanitary insecticidal composition containing flonicamid and pyrethroids and application thereof. The composition contains flonicamid and pyrethroid at a weight ratio of 1: 80-80: 1; the pyrethroid is high-efficiency cyhalothrin, high-efficiency cyfluthrin and bifenthrin; compared with single dose of unexpected toxicity synergy, the composition improves the insecticidal effect, and particularly improves the insecticidal effect on sanitary pests generating resistance to pyrethroid.

Description

Insecticidal composition containing flonicamid and pyrethroids and application

Technical Field

The invention relates to the field of sanitary insecticides, in particular to an insecticidal composition containing flonicamid and pyrethroids and application thereof.

Technical Field

Flonicamid (CAS number 158062-67-0) pyridine amide pesticide discovered by Japan stone Productus, Inc. has an action mechanism of inhibiting sucking action of piercing-sucking mouthpart pests to exert effects, stopping sucking immediately after the pests take the pesticide, and finally dying due to starvation, and has good internal absorption and osmosis effects. The flonicamid has low environmental toxicity and low toxicity to bees, fish, algae, birds and the like. At present, the research and application of the flonicamid environment mainly focus on preventing and controlling the field piercing-sucking pests such as bemisia tabaci, aphids, diaphorina citri, thrips and the like, and the research and application in the field of sanitary pests are few.

Cyhalothrin (Lambda-cyhalothrin, CAS number 91465-08-6), cyhalothrin (Beta-cyfluthrin, CAS number 68359-37-5) and Bifenthrin (Bifenthrin, CAS number 82657-04-3) are pyrethroid insecticides, and one of the main applications thereof is in the control of sanitary pests such as mosquitoes, flies, cockroaches, fleas, termites, and the like.

The hedgerow technology is an important control technology for controlling vector biological mosquitoes, and the principle is as follows: based on the fact that most of mosquitoes stay on the lower shady side of the plant branches and leaves, male mosquitoes live in the form of plant sap, most of female mosquitoes inhabit outdoors and enter the room at night to suck blood, the pyrethroid is sprayed to the shady side of the plant leaves by using an electrostatic spraying machine, and the mosquitoes are killed when the mosquitoes stay. The current pesticides used in hedgerow technology are all pyrethroid pesticides, and because of the long-term and large-scale use of the pyrethroid pesticides in mosquito control, mosquitoes have produced resistance to the pyrethroid pesticides to different degrees.

The applicant finds through a large number of experiments that the flonicamid is compounded with the insecticides of high-efficiency cyhalothrin, high-efficiency cyfluthrin, cyfluthrin and bifenthrin selected from pyrethroids, has unexpected toxicity synergism, particularly the hedge technology is used for preventing and controlling pyrethroid-resistant mosquitoes, and can realize better insecticidal activity than that of any one of the compounds used alone.

The compound composition has the characteristics of high efficiency, low toxicity and no irritation, is very suitable for preventing and controlling sanitary pests by outdoor spraying, and is particularly suitable for treating pyrethroid-resistant mosquitoes.

Disclosure of Invention

One of the purposes of the invention is to provide a compound insecticidal composition containing flonicamid and pyrethroid insecticide, which has good insecticidal effect and remarkable synergistic effect after compounding.

The invention also aims to provide the preparation and application of the sanitary insecticidal composition.

The above purpose of the invention is realized by the following technical scheme:

the sanitary insecticidal composition containing flonicamid is characterized by comprising the flonicamid and pyrethroids in a weight ratio of 1: 80-80: 1; the pyrethroid is lambda-cyhalothrin, lambda-cyhalothrin and bifenthrin.

Preferably, the carbamate is lambda-cyhalothrin or lambda-cyhalothrin, and more preferably, lambda-cyhalothrin.

In the sanitary insecticidal composition, the weight ratio of the two is 1: 40-40: 1, preferably 1: 20-10: 1, and more preferably 1: 5-5: 1.

The formulation of the sanitary insecticidal composition is missible oil, aqueous emulsion, microemulsion, wettable powder, suspending agent, suspending emulsion and microcapsule suspending-suspending agent; the dosage form is preferably a suspension and a microcapsule suspension-suspension.

The preparation prepared from the sanitary insecticidal composition is directly used or diluted by a solvent, and the application method, spraying, ultra-low volume, retention spraying (hedge technology), hot smoke, spraying and irrigation are selected according to the properties of the composition according to the purpose to be achieved and the environment to be located; the method of use is preferably retention spray hedge technology and spray.

The sanitary insect-killing composition is used for preventing and controlling sanitary insect pests, and is characterized in that the sanitary insect pests are mosquitoes and flies; preferably mosquitoes.

Compared with the prior art, the invention has the beneficial effects that:

(1) the insecticidal composition has unexpected synergistic effect on pests, improves knockdown and lethal effects, and has the synergistic coefficient of more than 120, even more than 210.

(2) The flonicamid is a pyridylamide pesticide, the high-efficiency cyhalothrin, the high-efficiency cyfluthrin and the bifenthrin are pyrethroid pesticides, and the two pesticides with different action mechanisms are compounded to treat pyrethroid resistant pests.

(3) The flonicamid has strong systemic activity and is absorbed by plants; the efficient cyhalothrin and the efficient cyhalothrin have strong contact killing activity and quick action and are retained on the shady side of the plant leaves; the two are compounded for preventing and controlling mosquitoes by hedge technology, the mosquitoes contact with the pyrethroid medicaments when staying, and the males eat flonicamid when absorbing juice, so that the mosquitoes with pyrethroid resistance can be treated on the premise of ensuring quick action and long action, and the mosquitoes are environment-friendly and safe to non-target organisms.

(4) The novel compound composition is added to the field of domestic sanitary pesticides, has obvious pesticide effect and can be widely popularized and applied.

Detailed Description

The present invention is further illustrated by the following examples, which are not intended to limit the invention to these embodiments. It will be appreciated by those skilled in the art that the present invention encompasses all alternatives, modifications and equivalents as may be included within the scope of the claims.

Formulation example 1: 12% flonicamid, lambda-cyhalothrin microcapsule suspension-suspending agent (1:5)

Dissolving 20g of efficient cyhalothrin, 5.0g of methyl oleate, 0.6g of diphenylmethane diisocyanate and 0.6g of toluene diisocyanate uniformly, adding the rest into an aqueous solution containing 1% of polyvinyl alcohol, shearing for 10min, slowly dropwise adding 0.2g of tetraethylenepentamine, stirring at 45 ℃, preserving heat and curing for 6h, adjusting the pH to 6.5 after the reaction is finished, and then uniformly stirring with a 4% flonicamid suspending agent prepared by an equivalent conventional method to obtain the microcapsule suspension-suspending agent preparation example 1.

Comparative example 1: high-efficiency cyhalothrin microcapsule suspending agent (10%)

Dissolving 10g of efficient cyhalothrin, 5.0g of methyl oleate, 0.6g of diphenylmethane diisocyanate and 0.6g of toluene diisocyanate uniformly, adding the dissolved solution into the aqueous solution containing 1% of polyvinyl alcohol in balance, shearing for 10min, slowly dropwise adding 0.2g of tetraethylenepentamine, stirring at 45 ℃, preserving heat and curing for 6h, and adjusting the pH to 6.5 after the reaction is finished to obtain the microcapsule suspending agent in comparative example 1.

Comparative example 2: 10% flonicamid suspension

10.0g of flonicamid is adsorbed by using 3.0g of white carbon black, 1.0g of fatty alcohol-polyoxyethylene ether, 2.0g of polycarboxylate, 2.0g of block polyether emulsifier, 0.3g of xanthan gum, 5.0g of ethylene glycol and 0.5g of potassium sorbate are mixed and ground to prepare the suspending agent of comparative example 2.

Application example 1: indoor bioactivity test of culex pipiens pallens

Test subjects: culex pipiens pallens, an indoor sensitive strain, and 3 rd to 5 th uninoculated female mosquitoes after eclosion.

Test agents: weighing flubendiamide, lambda-cyhalothrin and bifenthrin respectively, adding a proper amount of acetone for dissolving, adding distilled water for preparing mother liquor with required concentration, mixing the mother liquor according to a certain proportion to prepare mixed mother liquor, diluting the mixed mother liquor into a series of concentrations, and preparing the diluted solution into 5% medicine-containing sugar water.

The test method comprises the following steps: the test adopts stomach toxicity method, and 30 mosquitoes in each group are fed with medicinal sugar water, fed in standard way, repeated for 3 times, and the death number is counted after 24 hours.

And (3) test results: see table 1.

TABLE 1 flonicamid compound preparation for determining toxicity to culex pipiens pallens

By applying the LD of each formulation example in example 1₅₀And single dose LD₅₀The calculation method refers to the method of calculating the combined toxicity of the mixture through the toxicity index of the Sun Yunpei, and the co-toxicity coefficient is calculated, and the calculation result is shown in Table 2.

The calculation result shows that: when the compounding ratio of flonicamid to efficient cyhalothrin is 1: 80-80: 1, the co-toxicity coefficient is more than 120, and the synergistic effect is achieved, particularly when the compounding ratio is 1: 20-10: 1, the co-toxicity coefficient is more than 164.8, and particularly when the compounding ratio is 1:5, the co-toxicity coefficient is as high as 210.6; when the compounding ratio of flonicamid to high-efficiency cyfluthrin is 1: 20-5: 1, the co-toxicity coefficient is more than 153.5, and the synergy is obvious; when the compounding ratio of flonicamid to bifenthrin is 1: 5-5: 1, the co-toxicity coefficient exceeds 158.1, and the synergy is obvious.

TABLE 2 measurement results of the co-toxicity coefficient of the present invention

Application example 2: hedgerow technology field mosquito control test

Reagent to be tested: formulation example 1, comparative examples 1 to 2

The test method comprises the following steps: the gracilaria technology sprays insecticide on the surfaces of shrubs, lawns, trunks, ornamental flowers and trees and other vegetation around a building in a test area, the treated part is an area with the vegetation being less than 5 meters, major leaves face the lower surface, the steps are repeated for 3 times, a blank control group is set, and a mosquito and egg trapping device is adopted for monitoring once a week.

Evaluation index: the insect and egg trapping index has the following formula: the number of the recovered mosquito-lured ova devices is adult mosquitoes and/or mosquito eggs, and the recovered mosquito-lured ova devices are the positive mosquito-lured ova devices.

And (3) test results: in the table 3, the flonicamid-high-efficiency cyhalothrin microcapsule suspension-suspending agent hedge technology is used for preventing and treating the resistant mosquitoes on site, and the prevention and treatment rate and the lasting period are far higher than those of a single high-efficiency cyhalothrin agent and a single flonicamid agent.

Table 3 effect of flonicamid compounded insecticide hedgerow technology on controlling aedes.

The insecticidal composition containing flonicamid and pyrethroid and the application thereof have been described by specific examples, and the corresponding other objects can be achieved by appropriately changing the raw materials, the process conditions and the like by a person skilled in the art by referring to the contents of the invention, and the relevant changes do not depart from the contents of the invention, and all similar substitutions and changes are obvious to the person skilled in the art and are considered to be included in the scope of the invention.

Claims

1. The sanitary insecticidal composition containing flonicamid is characterized by comprising the following components in a weight ratio of 1: 80-80: 1; the pyrethroid is lambda-cyhalothrin, lambda-cyhalothrin and bifenthrin.

2. A sanitary insecticide composition as claimed in claim 1, wherein the weight ratio of the two is 1:40 to 40: 1.

3. A sanitary insecticidal composition according to claim 1, wherein the weight ratio of the two is 1:20 to 10: 1.

4. A sanitary insecticide composition as claimed in claim 1, wherein the weight ratio of the two is 1:5 to 5: 1.

5. A sanitary insecticidal composition as claimed in claim 1, wherein said pyrethroids are lambda-cyhalothrin and lambda-cyhalothrin.

6. A sanitary insecticidal composition according to any one of claims 1 to 4, wherein the formulation of said sanitary insecticidal composition is selected from the group consisting of emulsifiable concentrates, aqueous emulsions, microemulsions, wettable powders, suspensions, suspoemulsions, microcapsule suspension-suspensions.

7. The sanitary insecticide composition according to claim 5, wherein said formulation is a suspension and microcapsule suspension-suspension.

8. Use of the sanitary insecticidal composition according to any one of claims 1 to 6 for controlling sanitary pests, characterized in that the sanitary pests are mosquitoes, flies.

9. Use according to claim 7, characterized in that the sanitary pests are mosquitoes.