KR102050708B1 - Composition for disinfection and acaricide, and method for controlling of red mite using the same - Google Patents

Abstract

The present invention relates to a disinfecting and killing composition comprising peracetic acid and saturated fatty acid as an active ingredient, and chicken tick control method using the same. According to the present invention described above, tick control can be performed quickly and safely at the same time as the livestock house and poultry disinfection.

Description

Composition for disinfection and acaricide, and method for controlling of red mite using the same}

The present invention relates to a disinfecting and killing composition, and a method for controlling chicken ticks using the same. More specifically, the present invention relates to a method for disinfecting and killing livestock at the same time as the livestock and poultry disinfection can be quickly controlled and safe for killing, and chicken tick control method using the same.

Chicken mite ( Dermanyssus) , a kind of mite, also called wagumo Gallinae and red mite) are the most frequent pests in poultry farms due to the introduction of systemized cage structures.

Chicken mite is an external parasite belonging to the new mite family of thorn mites, and is parasitic to birds and has a habit of vampires for acts for nesting. Chicken mites are commonly parasitic in barn cages or utensils, and are known to cause blood loss by causing wounds on the skin of chickens at night for vampire blood to mediate the stress and disease of the chicken to drastically reduce egg production.

Chicken ticks are the most important external parasites that cause problems in spawning in poultry farming, and are found in most birds, including poultry, algae, and wild birds, which also cause farmers and workers to bleed and cause skin diseases. It may cause.

Representative damages caused by chicken ticks include, in particular, a drop in egg production due to anemia, mortality and stress, and contaminated eggs caused by other tick droppings and bloody ticks.

Representative agents used for controlling chicken ticks include pyrethroid, carbamate, and organophosphorus. Recently, phenylpyrazoe-based fipronil is also used. It is used. Formic acid and 2-tert-butyl-5- (4-terbutylbenzylthio) -4-chloropyridazine-3 (2H) -one from a domestic animal drug company A product called "wagupri" containing 4-tertbutylbenzylthio) -4-chloropyridazin-3 (2H) -one} has been released, but problems with resistance have arisen. Then bifenthrin (2-methyl [1,1'-biphenyl] -3-yl-methyl3- (2-chloro-3,3,3-trifluoro-1-propenyl2 (Bifenthrin (2 -methyl [1,1'-biphenyl] -3-yl-methyl3- (2-chloro-3,3,3-trifluoro-1-propenyl2) and 2-dimethylcyclopropanecarboxylate A product called "Wagupuri Blue" has been released.

Most chicken mite control agents are highly toxic, causing severe irritation and stress in animals, which can lead to a reduction in weight gain and a low egg production rate, and remain in chickens or eggs, causing serious secondary problems in food safety and hygiene. It is true.

Most of the drugs registered as veterinary medicines or quasi-drugs for controlling chicken ticks are using pesticides (EPA class 2) and have limitations for use in animals.

Therefore, there is an urgent need to develop acaricide compositions and preparation methods suitable for veterinary medicine or quasi-drugs.

Background art of the present invention is Republic of Korea Patent Publication No. 10-2012-0079706.

Throughout this specification, many papers and patent documents are referenced and their citations are indicated. The disclosures of cited papers and patent documents are incorporated herein by reference in their entirety, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained.

It is an object of the present invention to provide a disinfection and killing composition that can control ticks quickly at the same time as disinfecting barns and poultry, and is safe even in livestock.

Another object of the present invention is to provide a chicken tick control method that can control chicken ticks safely and efficiently by using the disinfecting and fleshing composition.

It is another object of the present invention to provide a method for efficiently preparing the disinfecting and killing composition.

Other objects and advantages of the present invention will become apparent from the following detailed description, claims and drawings.

According to one aspect of the invention, there is provided a disinfecting and killing composition comprising peracetic acid (peracetic acid) and saturated fatty acid as an active ingredient.

According to one embodiment of the present invention, 10 to 49 parts by weight of peracetic acid (peracetic acid); 0.1-15 parts by weight of saturated fatty acid; And 50 to 80 parts by weight of excipient.

According to one embodiment of the present invention, the saturated fatty acid may be at least one selected from pine oil, tall oil, and nimoil.

According to one embodiment of the present invention, the excipient may be at least one selected from surfactants, stabilizers, preservatives and solvents.

According to one embodiment of the present invention, the surfactant may be at least one selected from propylene glycol and sorbitane monooleate.

According to one embodiment of the invention, it may be for controlling chicken ticks.

According to another aspect of the present invention, acetic acid peroxide production step of producing a peracetic acid (peracetic acid) by reacting the organic acid and hydrogen peroxide; And a step of mixing saturated fatty acid and excipient with peracetic acid (peracetic acid).

According to one embodiment of the present invention, the mixing step may mix 10 to 49 parts by weight of peracetic acid (peracetic acid), 0.1 to 15 parts by weight of saturated fatty acid, and 50 to 80 parts by weight of excipients.

According to still another aspect of the present invention, there is provided a method for controlling ticks, wherein the disinfecting and killing composition is sprayed in an effective amount.

According to one embodiment of the invention, the tick may be a chicken tick.

According to one embodiment of the present invention, the tick can be controlled safely and quickly at the same time as the livestock house and poultry disinfection.

According to one embodiment of the present invention, chicken mites can be controlled safely and efficiently even with a low concentration of disinfecting and killing composition.

According to one embodiment of the present invention, to provide a method for efficiently preparing the disinfecting and killing composition.

Therefore, according to the present invention, mites, mites, and the like, which cause problems such as weight loss of the animal, low egg production rate, and increased stress, can be effectively controlled without problems due to the generation of toxicity and resistance to human beings.

1 is a photograph showing the results of confirming the production of acetic acid peroxide according to an embodiment of the present invention using a test kit.
Figure 2 is a flow chart schematically showing a method for producing a disinfecting and killing composition according to an embodiment of the present invention.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

According to one aspect of the invention, there is provided a disinfecting and killing composition comprising peracetic acid (peracetic acid) and saturated fatty acid as an active ingredient.

The acetic acid peroxide exhibits excellent efficacy as a major active ingredient for controlling mites at the same time as disinfection (see FIG. 1 and Table 1).

The acetic acid peroxide may be prepared by reacting acetic acid with hydrogen peroxide. Although not limited thereto, acetic acid peroxide may be prepared by reacting acetic acid with hydrogen peroxide in a ratio of 1: 0.3 to 1: 0.8. Acetic peroxide may be appropriately prepared by reacting acetic acid with hydrogen peroxide in a 1: 0.5 ratio.

The acetic acid peroxide may be included in 10 to 49 parts by weight. Although not limited thereto, disinfection and mite control activity may be insignificant when acetic acid peroxide is included in less than 10 parts by weight, and when contained in excess of 49 parts by weight, the content of other components is less, and thus the mite control activity is lowered. May cause side effects in the animal.

The saturated fatty acid is a plant-derived extract having an excellent insecticidal effect to give a synergistic effect by assisting the insecticidal power as a minor component. Saturated fatty acids are fatty acids that do not have a double bond in the molecule, and have a higher melting point and better oxidation stability than unsaturated fatty acids. Iodine is low in animal fat, vegetable fat and dry oil.

The saturated fatty acid may be at least one selected from pine oil, tall oil, and nimoil, but is not limited thereto.

The saturated fatty acid may be included in 0.1 to 15 parts by weight. Although not limited thereto, when less than 0.1 part by weight of saturated fatty acid may contain a small amount of mite control activity, when contained in more than 15 parts by weight, the content of other components is less, so the mite control activity is lowered or reduced May cause side effects.

Disinfecting and killing compositions of the present invention may further comprise excipients.

The excipient is a material added to make a certain form, it may be one or more selected from surfactants, stabilizers, preservatives and solvents.

The surfactant serves to diffuse the pesticidal active ingredient onto the treated surface such as the surface of the target livestock and tick, and an environment-friendly material is suitable. The surfactants include polyoxyethyl-polyoxypropylene polymers, glyceryl monooleate, lauryl sulfate, sorbitan esters, polyoxyethylene sorbitan fatty acid esters, hydrogen bonded ethoxylated castor oil, hydrogen bonded epoxylated triethanol It may be at least one selected from amines, polyoxyethylene sorbitan monooleate, propylene glycol and polyethylene glycol. Although not limited thereto, the surfactant may be one or more selected from propylene glycol and sorbitane monooleate.

The stabilizer may be a substance that contributes to increase long-term storage by stabilizing a state in which acetic acid peroxide and saturated fatty acid are dissolved or dispersed in a solvent. The stabilizer may be at least one selected from zinc phosphate, magnesium aluminum silicate, potassium sorbate, potassium bicarbonate, sodium acrylate polymer, sodium carboxymethyl cellulose, simethicone, dimethicone and xanthan gum.

The preservative may be used to increase the preservation of the solvent, including acetic acid peroxide and saturated fatty acid. The preservative may be at least one selected from methyl paraben, propyl paraben and benzyl alcohol.

The disinfecting and killing compositions of the present invention can be used for one or more control selected from chicken mites, house dust mites, hair mites, and ear mites. Although not limited thereto, the disinfecting and killing compositions of the present invention may be suitable for controlling parasitic chicken mites of poultry.

According to another aspect of the present invention, acetic acid peroxide production step of producing a peracetic acid (peracetic acid) by reacting the organic acid and hydrogen peroxide; And a step of mixing saturated fatty acid and excipient with peracetic acid (peracetic acid).

Figure 2 is a flow chart schematically showing a method for producing a disinfecting and killing composition according to an embodiment of the present invention.

Referring to FIG. 2, in step S100, acetic acid is prepared by reacting an organic acid and hydrogen peroxide in a ratio of 1: 0.3 to 1: 0.8. Although not limited thereto, acetic acid peroxide may be appropriately prepared by reacting an organic acid with hydrogen peroxide in a ratio of 1: 0.5. The organic acid may be acetic acid.

Next, in step S200, saturated fatty acids and excipients are mixed. The saturated fatty acid may be at least one selected from pine oil, tall oil, and nimoil, but is not limited thereto. The surfactant may be at least one selected from propylene glycol and sorbitane monooleate, but is not limited thereto.

In step S300 a mixture of acetic acid peroxide prepared in step S100 and saturated fatty acids and excipients in step S200 are mixed.

According to an embodiment of the present invention, in step S300, 10 to 49 parts by weight of peracetic acid (peracetic acid), 0.1 to 15 parts by weight of saturated fatty acid, and 50 to 80 parts by weight of an excipient may be mixed.

The acaricide composition of the present invention may be formulated in the form of granules, powders, liquid hydrating agents, hydrating agents and the like, but is not limited thereto, but hydrating agents are suitable.

The formulated acaricide composition of the present invention may be used by dilution to 500 to 2,000 times, preferably 1,000 times, in water prior to use.

According to still another aspect of the present invention, there is provided a method for controlling ticks, wherein the disinfecting and killing composition is sprayed in an effective amount.

According to one embodiment of the invention, the tick may be a chicken tick.

In the present invention, an effective amount is an amount sufficient to produce a beneficial or desired result. An effective amount can be administered one or more times.

The acaricide composition according to the present invention can generally be applied to a wide range of areas where the mites are or are expected to be prevalent, for example, in barns, utensils and poultry farms.

Hereinafter, the embodiment of the present invention will be described in detail. However, the following examples merely illustrate the present invention, and the present invention is not limited to the following examples.

[ Example  1] Preparation of Acetic Acid Peroxidation by Organic Acid and Hydrogen Peroxide

Acetic acid and hydrogen peroxide were reacted in a 1: 0.5 ratio to prepare acetic acid peroxide.

The prepared acetic acid peroxide was confirmed using the test kit to produce the amount of acetic acid peroxide (200mg per liter) (Fig. 1).

[ Example  2] Tick control of acetic acid peroxide was evaluated

The acetic acid peroxide prepared in Example 1 exhibits antiseptic power and is the main active ingredient of tick control. In order to confirm the mite control activity, the control value for each dilution factor was evaluated by using an outdoor collecting chicken mite (wagumo).

Chicken mites collected outdoors are placed on the bottom with agar medium in an insect dish (200 mesh mesh at the top and sprayed on the upper mesh net when spraying pharmaceuticals), 20 chicken ticks are selected, and 200 mg / l (Stock solution), 100 times, 200 times, 300 times, 400 times, and 500 times diluted in water and sprayed twice by hand spray. The control value evaluation was performed under a dissecting microscope 24 hours after acetic acid peroxide spraying. The results are shown in Table 1.

Concentration (dilution factor)
Manufactured acetic acid peroxide Raw data
(Pests / Pests) Control price (%) 200 mg / l (stock solution) 40/40 100 2 mg / l (100 times) 30/30 100  1 mg / l (200 times) 25/27 93 0.66 mg / l (300x) 35/46 76 0.5 mg / l (400 times) 23/43 53 0.4 mg / l (500 times) 1/28 4

As shown in Table 1, the hydrogen peroxide acetic acid produced by the Example 1 is a control up to 200 times that is 90%, the control at 400 times the half lethal concentration (LD ₅₀₎ exhibited a 50%.

[ Example  3] Preparation of saturated fatty acid mixture and evaluation of tick control

Saturated fatty acid mixture is prepared by using 0.1-10% of nim oil as saturated fatty acid, less than 5% of propylene glycol (PG) as excipient, and 90% or more of water as solvent and evaluating the control value by dilution factor in the same manner as in Example 2. (Table 2).

The control value evaluation was carried out under a dissecting microscope after 24 hours of saturated fatty acid spraying and the results are shown in Table 2.

Concentration (dilution factor)
Controlled by saturated fatty acid mixture treatment Raw data
(Pests / Pests) Control price (%) 7500 ppm Neemoil
(Stock) 31 of 31 100 75 ppm Nimeoil (100 times) 36/36 100 37.5 ppm Neemoil (200x) 25/41 61 25 ppm Neemoil (300x) 15/35 43 18.75 ppm Neemoil (400x) 5/46 11 15 ppm Neemoil (500 times) 1/43 2

As shown in Table 2, the prepared saturated fatty acid had a control value of 100% up to 100 times, and a control value of 50% at 250 times the LDF (LD ₅₀ ).

[ Example  4] Preparation of chicken tick control composition

In order to prepare a composition for controlling chicken ticks, it was prepared with the ingredients and ratios shown in Table 3.

At this time, in the same manner as in Example 1 was prepared by acetic acid and acetic acid peroxide reaction according to the hydrogen peroxide reaction, mixed with a saturated fatty acid excipient and then mixing the two components in proportion.

Component
content (%) Hydrogen Peroxide (H ₂ O ₂ ) 26.7 Acetic acid 13.3 Neemoil 7500 ppm 10 Propylene Glycol (PG) 50 Sum 100

[ Example  5] Evaluation of the control of the composition for controlling chicken ticks

The drug was diluted according to the dilution fold concentration of the chicken mite control composition prepared in Example 4, and the composition was sprayed in the same manner as in Example 2, and after 24 hours, the control value was evaluated for each dilution fold. In addition, the comparative example (product name: wagufreeblue, palm Hannong) and the control value was compared and confirmed (Table 4).

Dilution factor
Comparative example (wagupri-blue)
Example Raw data
(Pests / Pests) Control price (%) Raw data
(Pests / Pests) Control price (%) 0 (stock) 20/20 100 23/23 100 50 times
(Recommended dilution factor) 27/27 100 24/24 100 100 times 31 of 31 100 28 of 28 100 200 times 25/26 96 21/22 95 300 times 21/27 78 21/27 78 400 times 12/24 50 20/28 71 500 times 3/27 11 12/30 40

As shown in Table 4, when comparing the comparative example and the control agent (the pesticide Bifenthrin contains a pesticide chicken tick due to the effect of biventhrin), the difference in the control value from 400-fold dilution clearly It was confirmed that a difference appeared. That is, in the case of 400-fold dilution, the Example was 71% in control, whereas the Comparative Example was 50% in control, 21% difference.

Therefore, the composition according to the embodiment was confirmed to show a higher activity than the acaricide of the pesticide component against chicken mites (mite, wagumo).

According to the present invention, mites, mites, and the like, which cause problems such as weight loss, low egg production, and increased stress of animals, can be effectively controlled without problems due to the generation of toxicity and resistance to the human being.

Although specific portions of the present invention have been described in detail above, it will be apparent to those skilled in the art that these specific techniques are merely examples of preferred embodiments, and thus the scope of the present invention is not limited thereto. Therefore, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.

Claims (10)

10 to 49 parts by weight of peracetic acid;
0.1-15 parts by weight of saturated fatty acid; And
50 to 80 parts by weight of propylene glycol; comprising;
The saturated fatty acid may be Niemoil and Pine oil; Nimoil and Tall oil; Or Nimeil, Pine oil, and Tall oil; Phosphorus,
Disinfection and killing compositions for chicken tick control. delete delete The method of claim 1,
Disinfecting and killing composition further comprising at least one selected from surfactants, stabilizers, preservatives and solvents. The method of claim 4, wherein
Disinfecting and killing composition further comprising sorbitane monooleate. delete An acetic acid peroxide production step of reacting acetic acid with hydrogen peroxide to produce peracetic acid; And
10 to 49 parts by weight of peracetic acid (peracetic acid) mixed with 0.1 to 15 parts by weight of saturated fatty acid, and 50 to 80 parts by weight of propylene glycol; includes;
The saturated fatty acid may be Niemoil and Pine oil; Nimoil and Tall oil; Or Nimeil, Pine oil, and Tall oil; Phosphorus,
A method of preparing a disinfecting and killing composition for chicken tick control. delete A method for controlling a chicken tick, wherein the disinfecting and killing composition according to any one of claims 1, 4 and 5 is sprayed in an effective amount. delete

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