KR20190084432A - Composition for disinfection and acaricide, and method for controlling of red mite using the same - Google Patents

Abstract

The present invention comprises a disinfective and acaricidal composition comprising peracetic acid and saturated fatty acid as active ingredients, and a control method of Dermanyssus gallinae using the same. According to the present invention, pens and poultry farm are disinfected, and the control of Dermanyssus gallinae can be performed quickly and safely at the same time.

Description

TECHNICAL FIELD The present invention relates to a composition for disinfection and remediation, and a method for controlling chicken mites using the composition,

The present invention relates to a composition for disinfection and living, and a method for controlling chicken mites using the composition. More particularly, the present invention relates to a composition for disinfection and living, which is capable of rapid mite control simultaneously with house and poultry disinfection, and which is safe to be applied to a human body, and a method for controlling chicken mites using the same.

As a kind of mite, a chicken mite called Wagumo ( Dermanyssus gallinae , red mite) have been increasingly affected by the introduction of systematic cage structures, which are the most frequent pests in poultry farms.

Chicken mites are external parasites belonging to the bird mites of the thrips of the thorns. They are parasitic on the birds and have a habit of sucking blood on behalf of them. It is known that chicken mites are parasitized in a cage or apparatus of a stall, and it is known that it hurts the skin of a chicken at night to vomit and acts as a blood-sucking action, thereby mediating the stress and disease of the chicken,

Currently, chicken mites are the most important external parasites that cause problems in spawning in the poultry industry. It is a species found in most birds including poultry, leafy and wild birds. It is also a cause of skin diseases due to the blood of farmers and workers. .

Representative damages caused by chicken mites include anemia, mortality, low egg production due to stress, and the generation of pollutants caused by other tick excretions or blood-sucking mites.

Examples of the medicines used for controlling these chick mites include pyrethroid, carbamate, and organophosphorus. Recently, phenylpyrazole-based fipronil . Formic acid and 2-tert-butyl-5- (4-tertbutylbenzylthio) -4-chloropyridazine-3 (2H) 4-tertbutylbenzylthio) -4-chloropyridazin-3 (2H) -one} was released, but a problem occurred due to resistance. Bifenthrin (2-methyl [1,1'-biphenyl] -3-yl-methyl 3- -methyl [1,1'-biphenyl] -3-yl-methyl3- (2-chloro-3,3,3-trifluoro-1-propenyl2) and 2-dimethylcyclopropanecarboxylate "Wig Free Blue" was released.

Most chick mite control agents are highly toxic, causing extreme irritation and stress to animals, resulting in decreased body weight and lowering of egg production, resulting in residual chickens and eggs, resulting in serious secondary problems in food safety and hygiene It is true.

In order to control chicken ticks, most of the drugs registered as veterinary drugs or quasi-drugs use pesticides (EPA class 2 substances) and have limitations in using them for animals.

Accordingly, it is urgent to develop an acarbicide composition and a manufacturing method suitable for an animal medicine or a quasi-drug.

A background art of the present invention is Korean Patent Laid-Open No. 10-2012-0079706.

Numerous papers and patent documents are referenced and cited throughout this specification. The disclosures of the cited papers and patent documents are incorporated herein by reference in their entirety to better understand the state of the art to which the present invention pertains and the content of the present invention.

It is an object of the present invention to provide a composition for disinfection and poultry which is capable of quickly controlling mites and safely man-made while simultaneously disinfecting poultry and poultry.

It is another object of the present invention to provide a method for controlling chicken mites that can safely and efficiently control chicken mites using the composition for sterilizing and sterilizing.

It is still another object of the present invention to provide a method for efficiently producing the composition for disinfection and sterilization.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

According to an aspect of the present invention, there is provided a composition for disinfection and flesh containing peracetic acid and a saturated fatty acid as an active ingredient.

According to one embodiment of the present invention, 10 to 49 parts by weight of peracetic acid; 0.1 to 15 parts by weight of saturated fatty acids; And 50 to 80 parts by weight of an excipient.

According to an embodiment of the present invention, the saturated fatty acid may be at least one selected from the group consisting of Pine oil, Tall oil, and Nemoil.

According to one embodiment of the present invention, the excipient may be at least one selected from a surfactant, a stabilizer, a preservative and a solvent.

According to one embodiment of the present invention, the surfactant may be at least one selected from propylene glycol and sorbitan monooleate.

According to one embodiment of the present invention, it may be one for controlling chicken mite.

According to another aspect of the present invention, there is provided a process for preparing peracetic acid, which comprises reacting an organic acid with hydrogen peroxide to produce peracetic acid; And a method for preparing a composition for disinfection and fats, which comprises mixing saturated fatty acids and excipients with peracetic acid.

According to an embodiment of the present invention, the mixing may include mixing 10 to 49 parts by weight of peracetic acid, 0.1 to 15 parts by weight of saturated fatty acid, and 50 to 80 parts by weight of excipient.

According to another aspect of the present invention, there is provided a method of controlling ticks, which comprises spraying an effective amount of the composition for disinfection and flesh.

According to an embodiment of the present invention, the mite may be a chicken mite.

According to one embodiment of the present invention, it is possible to safely and quickly control mites at the same time as housing and poultry disinfection.

According to one embodiment of the present invention, it is possible to safely and efficiently control chicken mite even with a composition for low disinfection and mortality.

According to an embodiment of the present invention, there is provided a method for efficiently manufacturing the composition for sterilizing and sterilizing.

Therefore, according to the present invention, it is possible to effectively control ticks, mites and the like causing problems such as weight loss of an animal, lowering of egg production rate and stress, and the like without problems caused by toxicity and tolerance to the human body.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a photograph showing the result of confirming the production of peracetic acid according to an embodiment of the present invention by using a test kit. FIG.
FIG. 2 is a flowchart schematically showing a method of manufacturing a composition for disinfection and sterilization according to an embodiment of the present invention.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .

Hereinafter, the present invention will be described in detail.

According to an aspect of the present invention, there is provided a composition for disinfection and flesh containing peracetic acid and a saturated fatty acid as an active ingredient.

The peroxyacetic acid exhibits disinfecting power and exhibits excellent efficacy as a main active ingredient for mite control (see FIG. 1 and Table 1).

The peracetic acid may be prepared by reacting an organic acid with hydrogen peroxide. Although not limited thereto, peracetic acid can be prepared by reacting an organic acid with hydrogen peroxide in a ratio of 1: 0.3 to 1: 0.8. Peroxyacetic acid may be suitably prepared by reacting an organic acid with hydrogen peroxide in a 1: 0.5 ratio. The organic acid may be acetic acid.

The peroxyacetic acid may be included in an amount of 10 to 49 parts by weight. However, if it contains less than 10 parts by weight of acetic acid peroxide, the disinfection and mite controlling activity may be insignificant. If the amount of acetic acid is more than 49 parts by weight, the content of other constituents may be decreased, It can cause side effects on the person's axis.

The saturated fatty acid is a plant-derived extract having an excellent insecticidal effect and is a subordinate component and assists the insecticidal power to give a synergistic effect. Saturated fatty acids are fatty acids that do not have a double bond in the molecule and have a higher melting point than unsaturated fatty acids and have better oxidation stability. Iodine is low in animal fats, vegetable fats, and dry oils.

The saturated fatty acid may be at least one selected from Pine oil, Tall oil, and Nemoil, but is not limited thereto.

The saturated fatty acid may be included in an amount of 0.1 to 15 parts by weight. When the content of saturated fatty acids is less than 0.1 part by weight, the activity of controlling mites may be insignificant. When the content of saturated fatty acids is more than 15 parts by weight, the content of other constituents is decreased and the activity of controlling mites is lowered. It can cause side effects.

The composition for disinfection and flesh of the present invention may further comprise an excipient.

The excipient is added to make a certain form, and may be at least one selected from a surfactant, a stabilizer, a preservative and a solvent.

The surfactant serves to diffuse the insecticidal active ingredient to the treated surface such as the surface of the livestock and mites of the subject, and a substance which is environmentally friendly is suitable. The surfactant may be selected from the group consisting of polyoxyethyl-polyoxypropylene polymers, glyceryl monooleate, lauryl sulfate chloride, sucrose esters, polyoxyethylene sorbitan fatty acid esters, hydrogenated ethoxylated castor oil, hydrogenated epoxylated triethanol Amine, polyoxyethylene sorbitan monooleate, propylene glycol, and polyethylene glycol. The surfactant may be at least one selected from the group consisting of propylene glycol and sorbitan monooleate.

The stabilizing agent may be a substance which contributes to enhance long-term storage stability by stabilizing the state in which acetic acid peroxide and saturated fatty acid are dissolved or dispersed in a solvent. The stabilizer may be at least one selected from zinc phosphate, magnesium aluminum silicate, potassium sorbate, potassium bicarbonate, sodium acrylate polymer, sodium carboxymethylcellulose, simethicone, dimethicone and xanthan gum.

The preservative may be one containing peroxyacetic acid and saturated fatty acid and serving to enhance the shelf stability of the solvent. The preservative may be at least one selected from methylparaben, propylparaben, and benzyl alcohol.

The compositions for disinfection and dermatology of the present invention can be used in at least one kind of control selected from chicken mites, house dust mites, hair mites, and ear mites. The compositions for the disinfection and flesh of the present invention, although not limited thereto, may be suitable for controlling parasitic chicken mites of poultry.

According to another aspect of the present invention, there is provided a process for preparing peracetic acid, which comprises reacting an organic acid with hydrogen peroxide to produce peracetic acid; And a method for preparing a composition for disinfection and fats, which comprises mixing saturated fatty acids and excipients with peracetic acid.

FIG. 2 is a flowchart schematically showing a method of manufacturing a composition for disinfection and sterilization according to an embodiment of the present invention.

Referring to FIG. 2, in step S100, peroxyacetic acid is prepared by reacting organic acid and hydrogen peroxide in a ratio of 1: 0.3 to 1: 0.8. Although not limited thereto, peracetic acid may be suitably prepared by reacting an organic acid and hydrogen peroxide in a ratio of 1: 0.5. The organic acid may be acetic acid.

Next, in step S200, the saturated fatty acid and the excipient are mixed. The saturated fatty acid may be at least one selected from Pine oil, Tall oil, and Nemoil, but is not limited thereto. The surfactant may be at least one selected from propylene glycol and sorbitan monooleate, but is not limited thereto.

In step S300, a mixture of the peracetic acid produced in step S100 and the saturated fatty acid and excipient in step S200 is mixed.

According to an embodiment of the present invention, in step S300, 10 to 49 parts by weight of peracetic acid, 0.1 to 15 parts by weight of saturated fatty acid, and 50 to 80 parts by weight of excipients may be mixed.

The acarbicide composition of the present invention may be formulated in the form of granules, powders, liquid wettable powders, wettable powders, etc., but is not limited thereto, but a wettable powder is suitable.

The formulated acarbicide composition of the present invention is not limited thereto, but may be diluted with water to 500 to 2,000 times, preferably 1,000 times, before use.

According to another aspect of the present invention, there is provided a method of controlling ticks, which comprises spraying an effective amount of the composition for disinfection and flesh.

According to an embodiment of the present invention, the mite may be a chicken mite.

In the present invention, an effective amount is an amount sufficient to produce beneficial or desired results. An effective amount can be administered more than once.

The acaricidal composition according to the present invention can be applied to a wide area, for example in a dilute or non-diluted manner, for example in pens, appliances and poultry, where mites are prevalent or expected to spread.

Hereinafter, embodiments of the present invention will be described in detail. The following examples illustrate the present invention, but the present invention is not limited to the following examples.

[ Example  1] Preparation of peroxyacetic acid by reaction of organic acid with hydrogen peroxide

Acetic acid and hydrogen peroxide were reacted at a ratio of 1: 0.5 to prepare acetic acid peroxide.

The amount of peracetic acid produced (200 mg per liter) was confirmed using the test kit for peracetic acid produced (FIG. 1).

[ Example  2] Evaluation of mite control of peracetic acid

The peracetic acid produced in Example 1 exhibits disinfecting power and is the main active ingredient of the mite control. In order to confirm the activity of controlling the mites, we evaluated the control value of each dilution drainage by using outdoor chick mite (Wagumo).

The collected outdoor chick mites were placed in an insect dish (sprayed on top mesh network at the top with a 200 mesh mesh), agar medium was placed on the floor, 20 chicken mites were selected, and acetic acid peroxide was added at a dose of 200 mg / (Undiluted), 100 times, 200 times, 300 times, 400 times, 500 times, and sprayed twice by hand spray. Control The evaluation was carried out under a dissecting microscope 24 hours after application of acetic acid peroxide. The results are shown in Table 1.

Concentration (dilution factor)
The prepared peroxyacetic acid Raw Data
(Moth / insect) Control (%) 200 mg / l (undiluted solution) 40/40 100 2 mg / l (100-fold) 30/30 100  1 mg / l (200 times) 25/27 93 0.66 mg / l (300-fold) 35/46 76 0.5 mg / L (400 times) 23/43 53 0.4 mg / l (500 times) 1/28 4

As shown in Table 1, the peracetic acid produced by Example 1 had a control amount of 90% up to 200 times and a control amount of 50% with a half-life lethal concentration (LD ₅₀ ) of 400 times.

[ Example  3] Preparation of saturated fatty acid mixture and evaluation of tick control

The saturated fatty acid mixture was prepared by using 0.1-10% of nematic oil as a saturated fatty acid, less than 5% of polyphenylene glycol (PG) as an excipient, and 90% or more of water as a solvent. (Table 2).

The control was carried out under a dissecting microscope 24 hours after the application of the saturated fatty acid, and the results are shown in Table 2.

Concentration (dilution factor)
Saturated fatty acid Raw Data
(Moth / insect) Control (%) Saturated fatty acid 7500 ppm (undiluted solution) 31/31 100 Saturated fatty acid 75 ppm (100 times) 36/36 100 Saturated fatty acid 37.5 ppm (200 times) 25/41 61 Saturated fatty acid 25 ppm (300 times) 15/35 43 Saturated fatty acid 18.75 ppm (400 times) 5/46 11 Saturated fatty acid 15 ppm (500 times 1/43 2

As shown in Table 2, the prepared saturated fatty acid had a control rate of 100% up to 100 times and a control value of 50% with a half-life lethal concentration (LD ₅₀ ) of 250 times.

[ Example  4] Preparation of Composition for Control of Chicken Mite

In order to prepare a composition for controlling chicken mite, the composition and ingredients were prepared as shown in Table 3.

At this time, the peracid acetic acid according to the reaction of the organic acid and the hydrogen peroxide was prepared in the same manner as in Example 1, and the saturated fatty acid was mixed with the excipient, followed by mixing the two components in proportions.

Constituent
content (%) Hydrogen peroxide (H ₂ O ₂ ) 26.7 Organic acid 13.3 Saturated fatty acid 7500 ppm 10 Propylene glycol (PG) 50 Sum 100

[ Example  5] Evaluation of Control of Composition for Control of Chick Mite

The composition for controlling chicken mites prepared in Example 4 was diluted with the dilution water according to the concentration of each dilution, and the composition for control was sprayed in the same manner as in Example 2, and the control was evaluated for each dilution drainage after 24 hours. In addition, comparative examples (product names: Wagu Free Blue, Palm Hanong) and control agents were compared (Table 4).

Dilution factor
Comparative Example (Wagu Free Blue)
Example Raw Data
(Moth / insect) Control (%) Raw Data
(Moth / insect) Control (%) 0 (undiluted solution) 20/20 100 23/23 100 50 times
(Recommended dilution factor) 27/27 100 24/24 100 100 times 31/31 100 28/28 100 200 times 25/26 96 21/22 95 300 times 21/27 78 21/27 78 400 times 12/24 50 20/28 71 500 times 3/27 11 12/30 40

As shown in Table 4, when comparing the control and comparative examples (containing pesticide, bifenthrin, with the effect of biventricin, insect chick mites), the difference in the control from the 400-fold dilution was clearly A difference was observed. That is, in the case of the 400-fold dilution, the control was 71% in the example, whereas the control was 50% in the control and 21% in the control.

Therefore, it was confirmed that the composition according to the Example exhibited higher activity than the pesticide-based acaricide for chicken mites (mite, wagoo).

According to the present invention, it is possible to effectively control ticks, mites and the like causing problems such as weight loss of an animal, lowered egg production rate and stress, and the like without problems caused by toxicity and tolerance to the human body.

Although specific portions of the present invention have been described in detail, those skilled in the art will appreciate that these specific embodiments are merely examples of preferred embodiments and that the scope of the present invention is not limited thereto. It is therefore intended that the scope of the present invention be defined by the appended claims and their equivalents.

Claims (10)

A composition for disinfection and remediation comprising peracetic acid and saturated fatty acid as active ingredients. The method according to claim 1,
10 to 49 parts by weight peracetic acid;
0.1 to 15 parts by weight of saturated fatty acids; And
50 to 80 parts by weight of an excipient. 3. The method of claim 2,
Wherein the saturated fatty acid is at least one selected from the group consisting of Pine oil, Tall oil, and Nemoil. 3. The method of claim 2,
Wherein the excipient is at least one selected from a surfactant, a stabilizer, a preservative and a solvent. 5. The method of claim 4,
Wherein the surfactant is at least one selected from propylene glycol and sorbitan monooleate. The method according to claim 1,
A composition for the disinfection and killing of chicken mites. A peracetic acid production step of reacting an organic acid with hydrogen peroxide to produce peracetic acid; And
And mixing the peracetic acid with saturated fatty acid and an excipient. 8. The method of claim 7,
Wherein the mixing step comprises mixing 10 to 49 parts by weight of peracetic acid, 0.1 to 15 parts by weight of saturated fatty acid, and 50 to 80 parts by weight of an excipient. A method for controlling mites characterized by spraying an effective amount of the composition for disinfection and living according to any one of claims 1 to 6. 10. The method according to claim 9, wherein the mite is a chicken mite.

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