JP4627634B2 - Indoor dust mite repellent - Google Patents

Description

The present invention relates to an indoor dusty mite repellent.

A great variety of mites live on the earth. For example, citrus mites and nymph mites parasitizing plants cause great damage to crops. Acaricides aimed at controlling mites parasitic on these plants have been developed for a long time, and promising new compounds have been discovered one after another.
On the other hand, due to changes in the living environment in recent years, indoor dust mites such as mites, leopard mites, and dust mites are generated indoors, causing problems such as allergic asthma and skin eruption as well as discomfort. ing.
Therefore, there has been a demand for an indoor acaricide for treating carpets, bedding, etc., but a useful acaricide against mites parasitic on plants is not necessarily effective against indoor dust mites. There was a situation. This is thought to be due to species differences in which mites parasitizing plants mainly belong to the anterior genus, while dust mites that live indoors mainly belong to the aerial genus. Also, because there are many use cases that directly contact the skin indoors, it is necessary to develop a safer drug. Further, leopard mites that cause allergic asthma can cause allergies even in the corpse of the worm body itself. It has become clear.

Against this background, a technique for preventing tick from approaching people and patients rather than killing indoor dust mites has been sought, and several proposals have been made so far. For example, Japanese Patent Laid-Open No. 2-104503 discloses a mite control agent containing L-(−)-menthol as an active ingredient, and L-(−)-menthol has a repellent action against indoor dust mites. It is described to show. JP-A-6-16515 discloses plant essential oils such as vetiver oil, patchouli oil, and clove oil as active ingredients for indoor mite control agents, and JP-A-2001-31508 discloses 1,8- Although cineole or eucalyptus oil containing a large amount of this component is disclosed and consideration is given to natural products and safety, repellent efficacy against indoor dust mites is not satisfactory.
Further, there is a document characterized by a combination of phenothrin and diet as disclosed in JP-A-4-224712, but phenothrin is an acaricide and does not meet the purpose of the present invention.
Furthermore, as a method for removing mite allergens, for example, methods using components such as benzalkonium chloride and sesquiterpene alcohol have been proposed (JP 2001-335474 A and JP 2003-238394 A, respectively). . However, the application of these allergen reducing agents does not provide an allergen-reducing effect and does not have an action to keep ticks away, so that a practical clean environment cannot be created.
Japanese Patent Laid-Open No. 2-104503 Japanese Patent Laid-Open No. 6-16515 JP 2001-31508 A JP-A-4-224712 JP 2001-335474 A JP 2003-238394 A

The present invention provides an indoor dust mite repellent that can be applied to carpets, bedding, etc. with peace of mind because of its high safety against human livestock, and that has excellent repellent effect against dust mites, dust mites, dust mites, claw mites, etc. For the purpose.

In order to achieve the above object, the present invention adopts the following configuration.
(1) as repellent component, the weight ratio of (a) containing DEET and (b) L-menthol, and (a) :( b) 1: 0.12 to 1: 2.0, and the repellent An indoor dusty mite repellent, characterized in that the main solvent of the component is ethanol and further contains cyclic silicone .
(2) The indoor dusty mite repellent according to (1), which is blended with a mite allergen reducing agent containing a cationic surfactant or an anionic surfactant.

The indoor dust mite repellent of the present invention is extremely practical because it uses two repellent components with high safety and exhibits an excellent repellent effect due to its synergistic effect.

The diet used in the present invention is a component that is widely used as a pest repellent component for mosquitoes, gnats, flies and the like, and is known to exhibit a certain repellent effect against indoor dust mites.
On the other hand, although menthol has a repellent effect on indoor dust mites as described in JP-A-2-104503, it is not at a practical level.
In the present invention, however, (a) diet and (b) L-menthol are combined, and the weight ratio of (a) :( b) is specified in the range of 1: 0.12 to 1: 2.0, and the indoor dust is specified. The present inventors have found that the repellent efficacy against acarid mites, leopard mites, dust mites, claw mites and the like is synergistically increased and can be put to practical use by preparing a sex repellent.
When the weight ratio is less than 1: 0.12, the synergistic effect on the repellent efficacy improvement by the addition of L-menthol is not sufficient. On the other hand, when the weight ratio exceeds 1: 2.0, even if L-menthol is added, the repellency is only slightly increased, which is not economical and the odor becomes strong.
L-menthol is a preferable optically active substance in terms of repellent activity, but it may of course be a DL racemate that is a mixture with D-menthol, or mint oil containing a large amount of L-menthol may be used.

The indoor dust mite repellent of the present invention is not limited to (a) Diet and (b) L-menthol as long as it does not interfere with safety and repellent efficacy, such as other mite repellent components such as α- Essential oils and extracts derived from pinene, geraniol, camphor, linalool, caran-3,4-diol, or cinnamon, eucalyptus, citronella, neem, lavender, lemongrass, clover, bergamot and the like can be added.

Although the indoor dusty mite repellent of the present invention can be applied as it is, it is usually preferable to use various carriers and other additives, depending on the purpose of use. , Liquid formulation in the form of water, emulsion or suspension, including emulsions, wettable powders, oils, flowables, aqueous solvents, etc.), lotions and aerosols.
Examples of the liquid carrier include water, alcohols (ethanol, isopropanol, etc.), polyhydric alcohols (diethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, etc.), and ketones (acetone, methyl ethyl ketone, cyclohexanone, etc.). , Ethers (ethyl ether, dioxane, diethylene glycol monobutyl ether, propylene glycol monomethyl ether, etc.), aliphatic hydrocarbons (kerosene, kerosene, etc.), aromatic hydrocarbons (xylene, methylnaphthalene, etc.), esters, acids Solvents such as amides and nitriles are suitable, and one or a mixture of two or more of these is used.
Especially, since ethanol is excellent in quick-drying properties, a solution containing ethanol as a main solvent is suitable for treating carpets, bedding, etc., and further contains safety against fire and contains a cationic surfactant or an anionic surfactant. When considering the formulation of the mite allergen reducing agent, a mixed solvent of ethanol and water (for example, ethanol / water = 50/50 to 60/40) is more preferable.

On the other hand, as the solid carrier, for example, clays (kaolin, bentonite, etc.), talc, silica, alumina powder, activated carbon, cellulose-based or vegetable powder are suitable, and one or two of these are suitable. A mixture of the above is used.

Examples of the additive include a surfactant, a dispersant, a spreading agent, a penetrating agent, and a stabilizer, and one or a mixture of two or more of these may be used. For example, when 1 to 8% by weight, preferably 3 to 6% by weight of cyclic silicone is added to the indoor dusty mite repellent of the present invention, the fiber body is protected when treated on carpets or bedding. Useful.

The indoor dust mite repellent of the present invention preferably contains a mite allergen reducing agent containing a cationic surfactant or an anionic surfactant. That is, while the live mites are kept away from the target area, the allergen activity is reduced for the remaining dead mites and mite feces and the like, and a clean environment free from mite allergens can be efficiently provided.
Cationic surfactants include dilong chain alkyldishort chain alkyl quaternary ammonium salts (distearyldimethylammonium salt, distearylmethylhydroxyethylammonium salt, dioleyldimethylammonium salt, etc.), monolong chain alkyltrishort chain Examples include alkyl type quaternary ammonium salts (such as lauryl trimethyl ammonium salt and stearyl dimethyl benzyl ammonium salt) and tri long chain alkyl mono short chain alkyl type quaternary ammonium salts (such as trilauryl methyl ammonium chloride and tristearyl methyl ammonium chloride). . In addition, the mixing | blending of a suitable quantity cationic surfactant also has the merit that a softness | flexibility can be provided to a process fiber body.
On the other hand, examples of anionic surfactants include lauryl benzene sulfonate, lauryl sulfate, lauryl sulfate triethanolamine, and polyoxyethylene lauryl ether sulfate. An agent may be configured.
The blending amount of the mite allergen reducing agent is suitably 0.2 to 10% by weight, and excessive application is not preferable because it may impair the feel of the fibrous body.

Moreover, as a propellant used when preparing an aerosol, dimethyl ether, liquefied petroleum gas, compressed gas (nitrogen, carbon dioxide gas, etc.) is mention | raise | lifted.
Furthermore, a multi-purpose composition comprising an acaricide, an insecticide, a fungicide, an antifungal agent, a flavoring agent, a coloring agent, etc., which is not likely to inhibit the activity of the indoor dusty mite repellent of the present invention, It is also possible to do.

The amount of active ingredient in the indoor dust mite repellent of the present invention and the amount of use thereof are appropriately determined according to the dosage form, application object, application method, application location, and the like. For example, when targeting leopard mites that inhabit the carpet, the application amount of (a) diet and (b) L-menthol is 1.0 mg or more per 1 m ² in total of (a) and (b), preferably What is necessary is just to set so that it may become 10 mg-1000 mg.

The indoor dusty mite repellent of the present invention thus obtained can be safely applied to carpets and bedding due to its high safety against human livestock, and has excellent repellent efficacy against dust mites, leopard mites, dust mites, claw mites, etc. Play. Therefore, it does not come into contact with indoor mites that cause allergies, and if a mite allergen reducing agent is added, allergen activity caused by dead mites and mite feces can be suppressed, so it can be used as a substitute for acaricides. As such, its practicality is extremely high.

Next, based on a specific Example, the indoor dusty mite repellent of this invention is demonstrated in detail.

Dissolve 4.0g diet and 1.0g L-menthol as an indoor dusty mite repellent component, 3.0g cyclic polysiloxane, and 0.5g cationic surfactant in 100mL ethanol and fill into a bottle with a trigger A spray-type indoor dusty mite repellent was prepared.
About 1/4 of this indoor dusty mite repellent was sprayed onto a 3 m ² carpet laid in the living room. When the carpet was observed after 1 day, 3 days, 1 week, and 2 weeks, no infestation of leopard mites was observed.

1. Mite allergen reducing agent containing diet 4.0g and L-menthol 0.5g as an indoor dusty mite repellent component, anionic surfactant (polyoxyethylene lauryl ether sulfate) and phenolic polymer. 0 was dissolved in 100 mL of an aqueous ethanol solution (ethanol / water = 55/45) and filled in a bottle with a trigger to prepare a spray-type indoor dusty mite repellent.
When about 20 mL of the indoor dusty mite repellent was sprayed onto the bedclothes in the bedroom, no leopard mites were found to be observed at all after one week. Moreover, mite allergen activity caused by dead mites and mite feces could be suppressed, and a clean environment free from mite allergens could be created.

According to Example 1, various indoor dust mite repellents (solvent: ethanol) shown in Table 1 were prepared, and the following repellent efficacy tests were performed.
[Repellent efficacy test]
A petri dish having a diameter of 9 cm was fixed on the pressure-sensitive adhesive sheet, and about 10,000 individual leopard mites or prickly tick were released in the petri dish together with the medium. Next, a drug-treated carpet having a diameter of 4 cm (treated with a predetermined amount of drug on an untreated carpet and then air-dried for 2 hours) was fitted in a petri dish having a diameter of 4 cm, and 50 mg of a reference medium was placed in the center. This petri dish with a diameter of 4 cm was placed in the center of the petri dish with a diameter of 9 cm and stored under dark conditions at 25 ° C. and 75% RH. Similarly, an untreated section was made using carpet that was not subjected to chemical treatment. The number of mite individuals that entered the central carpet after 24 hours was counted, and the repelling rate was calculated according to the following formula.
Repellent rate (%) = [number of invading ticks in untreated area-number of invading ticks in treated area] / number of invading ticks in untreated area
× 100

As a result of the test, the indoor dusty mite repellent of the present invention shows a high repellent effect on both the leopard mite and the mite mite due to the synergistic effect of (a) Diet and (b) L-menthol, and the point of smell But there was no problem. It should be noted that the combination of mite allergen reducing agents containing cationic surfactants or anionic surfactants is useful in terms of suppressing mite allergen activity due to dead mites and mite feces, and improving repellent efficacy. Was recognized.
On the other hand, as shown in Comparative Examples 1 to 4, diet and L-menthol alone had inferior repellency. Further, as in Comparative Example 5, when the blending amount of L-menthol was less than 0.12 times the diet, a synergistic effect by mixing could not be obtained. Next, based on this invention 4 and Comparative Examples 6-10, the repellent efficacy in the case of single and the mixture with diet was compared about three types of natural essential oils (mint oil, eucalyptus oil, citronella oil). As a result, the three kinds of natural essential oils had almost the same repellent efficacy by themselves, but the synergistic effect by mixing with diet was found to be significantly higher in mint oil, that is, L-menthol. Citronella oil can be expected to have an appropriate repellent effect if the amount is increased, but the odor is too strong to be practical. Furthermore, the sesquiterpene alcohol (Comparative Example 11) proposed as an allergen reducing agent has low repellent efficacy, and it was considered difficult to solve the mite allergen problem comprehensively only by application of the allergen reducing agent.

Since the indoor dusty mite repellent of the present invention uses diet and L-menthol, which are highly safe for the human body, it may be applicable not only to indoor mites but also to indoor pests such as cockroaches. is there.

Claims (2)

As repellent component, (a) containing DEET and (b) L-menthol, and the weight ratio of (a) :( b) is 1: 0.12 to 1: 2.0, and mainly of the repellent component An indoor dusty mite repellent, characterized in that the solvent is ethanol and further contains cyclic silicone . The indoor dusty mite repellent according to claim 1, wherein a mite allergen reducing agent containing a cationic surfactant or an anionic surfactant is blended.