JP3465854B2 - Indoor dust mites - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an indoor dust scavenging mite agent.

[0002]

2. Description of the Related Art A great variety of mites live on the earth, and for example, citrus spider mites and worm spiders parasitic on plants cause great damage to agricultural products. Acaricides for the purpose of agricultural use against these mites have been developed for a long time, and recently new promising compounds have been discovered one after another. On the other hand, in recent years, due to changes in the living environment, indoor dust mites such as mites, leopard mites, and tick mites have occurred, causing not only discomfort, but also causing problems such as allergic asthma and skin rashes. . Organic phosphorus agents such as fenitrothion and diazinon and pyrethroid agents such as phenothrin and permethrin are known to be effective against indoor dust mites that occur indoors, but they can be sprayed in large amounts on the entire surface. Necessary, human,
In particular, it is not practical because of safety concerns for children. Recently, attempts to apply compounds other than insecticides such as terpene compounds and plant essential oils to acaricides have been disclosed, but they are not sufficient. In addition, indoor dust mites are generally vulnerable to heat, die almost completely at 70 ° C for a few minutes, and cannot grow in a dry state. Although the effective tick control method is also effective, it has many obstacles in terms of simplicity, and establishment of an accurate control method is desired.

[0003]

SUMMARY OF THE INVENTION In view of the above situation, the present invention has been made with the object of developing an indoor slaughterhouse dust mite agent that can be safely used indoors.

[0004]

In order to solve the above problems, the inventors of the present invention have conducted extensive studies, and as a result, the glycol ether compound of the general formula I widely used in the field of surfactants etc. The present invention has been found to have no repellent property against indoor dust mites such as Dermatophagoides farinae and genus mite, and has a high acaricidal effect.

That is, according to the invention of claim 1, as the acaricidal component, the compound of the general formula I

[Chemical 3] (In the formula, when m is an integer of 1 to 3 and n is 0, R ₁ represents a butyl group, a hexyl group, an octyl group, a benzyl group or a phenyl group, and R ₂ represents a hydrogen atom, a butyl group, a hexyl group. Represents a group, an octyl group, a benzyl group or a phenyl group.
Is 0 and n is an integer of 1 to 3, R ₁ represents a butyl group, a hexyl group or a phenyl group, and R ₂ represents a hydrogen atom. When m is 2 and n is an integer of 2, R ₁ represents a butyl group or a hexyl group, and R ₂ represents a hydrogen atom. And a glycol ether compound represented by the formula (1).

The compounds represented by the general formula I include ethylene glycol (m; 1,2,3) monoalkyl ether (alkyl; butyl, hexyl, octyl), ethylene glycol (m; 1,2,3) mono. Benzyl ether, ethylene glycol (m; 1,2,3) monophenyl ether, ethylene glycol (m; 1,2,3) dialkyl ether (alkyl; butyl, hexyl, octyl), ethylene glycol (m; 1,2,3) 3) Dibenzyl ether, ethylene glycol (m; 1,2,3)
Diphenyl ether, propylene glycol (n; 1,
2,3) monoalkyl ether (alkyl; butyl, hexyl), propylene glycol (n; 1,2,3) monophenyl ether, ethylene propylene glycol (m; 2, n; 2) monoalkyl ether (alkyl;
Butyl and hexyl).

Furthermore, the invention of claim 2 is the invention of claim 1 in which a chitin synthesis inhibitor is added. While conventional organophosphates and pyrethroids act as neurotoxins, chitin synthesis inhibitors inhibit the chitin synthesis pathway peculiar to insects and mites, so they are almost harmless to humans and animals, and long-term tick growth A suppression effect can be expected.

The invention of claim 3 is the same as the invention of claim 2, wherein N- (2- is particularly useful among chitin synthesis inhibitors.
Chlorobenzoyl) -N- [4- (2-chloro-4-trifluoromethyl-1-phenylmercapto) phenyl] urea (hereinafter referred to as compound A) is blended. Compound A is known in Japanese Patent Application Laid-Open No. 2-270, but the inventors of the present invention continue to study further and show that Compound A exhibits a particularly high acaricidal effect and growth inhibitory effect against indoor dust mites. Has already been clarified (Japanese Patent Laid-Open No. 5-3
12645).

[0009]

According to the constitution of claim 1, a very useful indoor dust mite agent is provided. That is, the glycol ether compound represented by the general formula I is not repellent against indoor dust mites such as mites, leopard mites, and tick mites, has a high acaricidal effect, and is highly safe for humans and animals. In addition, since certain compounds can be used as a solvent for other active ingredients, there is an advantage that an admixture can be easily prepared. When the compound of the general formula I is used as an active ingredient of the indoor miticidal mite agent of the present invention, it may be used as it is without adding any other component, but it may be used as a solid carrier, liquid carrier or gaseous carrier. , Surfactants, other formulation aids,
It is generally used by mixing with a feed or the like and formulating into powders, granules, aerosols, emulsions, water solutions, smoke agents, poison baits, sheets and the like.

Examples of solid carriers include clays (kaolin, bentonite, etc.), talcs, silicas, alumina powders, activated carbons, plant powders, and the like, and liquid carriers include, for example, water and alcohols (methyl alcohol). , Ethyl alcohol, ethylene glycol, etc.), ketones (acetone, methyl ethyl ketone, cyclohexanone, etc.), ethers (ethyl ether, dioxane, etc.),
Aliphatic hydrocarbons (gasoline, kerosene, kerosene, etc.),
Suitable solvents include aromatic hydrocarbons (benzene, toluene, xylene, methylnaphthalene, etc.), halogenated hydrocarbons (dichloromethane, trichlorobenzene, etc.), esters, pyrrolidones, nitriles, etc. Seeds or mixtures of two or more can be used. Further, LPG (liquefied petroleum gas), dimethyl ether, CFC gas and the like are used as the gaseous carrier, and alkyl sulfate ester salt, alkyl sulfonate and the like are used as the surfactant.
Any commonly available substance such as sorbitan fatty acid ester and polyoxyethylene polyoxypropylene block polymer can be arbitrarily used. Furthermore, as a formulation auxiliary agent,
A dispersant, a fixing agent, a stabilizer and the like are used as appropriate.

The indoor disinfectant mites of the present invention have the general formula I
As long as it does not inhibit the activity of the compound represented by, it is a multipurpose composition containing other acaricides, insecticides, fungicides, repellents, synergists, antifungal agents, growth regulators, flavoring agents, coloring agents, etc. You can also get things. For example, as insecticides, fenitrothion, diazinon, organic phosphorus agents such as propetanphos,
Pyrethroids such as phenothrin, permethrin, resmethrin, etofenprox and empentrin, compounds such as silafluofen and pyriproxyfen, and chitin synthesis inhibitors such as compound A, diflubenzuron, teflubenzuron, chlorfluazuron and flufenoxuron Can be mentioned. Also, as a repellent,
N, N-diethyl-m-toluamide, benzyl benzoate and the like are used as synergists such as piperonyl butoxide, octachlorodipropyl ether, N- (2-ethylhexyl) -bicyclo- [2,2,1] hepta. -5-en-
Examples include 2,3-dicarboximide and isobornyl thiocyanoacetate.

According to the constitution of claim 2, since the chitin synthesis inhibitor is mixed, it is expected that the chitin synthesis inhibitor has a slow effect of suppressing tick growth in addition to the fast acaricidal effect of the compound of the general formula I. it can.

According to the constitution of claim 3, since compound A which is particularly useful among the chitin synthesis inhibitors is compounded, it is possible to obtain an indoor miticidal mite agent exhibiting a synergistic high acaricidal effect by both active ingredients. You can Although benzoylurea-based compounds containing compound A generally have low solubility in petroleum-based, ester-based solvents, etc., certain compounds of general formula I have the advantage that they can also be used as a solvent for compound A.

The amount of the active ingredient and the amount of the active ingredient in the indoor disinfectant mite preparation of the present invention are appropriately determined depending on the dosage form, application target, application method, application site and the like. For example, it is preferable that 1 mg or more of the compound of the general formula I is applied per 1 m ^{2 for} the control of deer miters and the like that inhabit carpets. The compound of the general formula I acts as a contact poison, but the chitin synthesis inhibitor acts not only as a contact poison but also as a food poison. Therefore, in the mixture of the two, the use form of the bait agent mixed in feed etc. Is also effective. In this case, 0.
Sufficient effect can be obtained in the range of 1 ppm to 1.0%, and due to both contact poison and food poisoning, it is not a uniform treatment on the entire surface.
A high acaricidal effect can be achieved even with partial treatment. Note that conventional organophosphorus agents and pyrethroid agents are not suitable for mixing with chitin synthesis inhibitors because they show some repellent properties against indoor dust mites.

As described above, the indoor miticidal mite agent of the present invention exhibits a high miticidal effect against indoor mite dust mites such as mites, deer mites, and tick mites, and is extremely safe for humans and animals. The present invention provides an accurate method for treating chemicals, which replaces the conventional organophosphorus agent and pyrethroid agent. In addition, since the compound of the general formula I is chemically safe and has a good residual effect, this agent not only disinfects after the occurrence of indoor dust mites but also pre-treats carpet, futon, futon, etc. It is also extremely useful as a so-called preventive treatment agent.

[0016]

EXAMPLES The present invention will be described in more detail with reference to test examples and examples, but the present invention is not limited to the following examples as long as the gist thereof is not exceeded.

[0017]

[Test Example 1] A solution prepared by diluting a reagent agent with acetone to a predetermined concentration in 0.5 cm on a filter paper of 5 cm x 10 cm.
Each one was added dropwise and air dried for 3 hours. Approximately 100 individuals of the fresh mosquito leopard mite were inoculated into the center of the folded filter paper, and sandwiched from above and below with an acrylic ring (outer diameter 5 cm, height 2 cm), and two rubber bands were fixed in a cross shape. Then, it was placed in a container whose relative temperature was adjusted to about 65%, and allowed to stand in a thermostatic chamber at a temperature of 25 ± 1 ° C. After contacting the filter paper for 24 hours, the number of live and dead mites was counted under a stereoscopic microscope. For the determination of life or death, those who did not move their legs were treated as dead individuals. The test was conducted in triplicate for each test section, and the mortality rate was calculated according to the following formula. The results are shown in Table 1.

[0018]

[Table 1]

As a result of the test, the indoor dust-killing agent of the present invention showed a high mortality rate. On the other hand, even for glycol ether compounds, monoethyl ether (Control 1) and diethyl ether type (Control 2) are unsuitable, and those with glycol polymerization number of 4 or more (Controls 3 and 4) are almost killed. It did not show a tick effect. Therefore, it was revealed that only the specific glycol ether compound corresponding to the general formula I exhibits a high acaricidal effect.

[0020]

[Test Example 2] As a test carpet, a commercially available carpet (100% wool, no wool mark, cut type,
A pile length of 7 mm) was cut into a size of 5 cm × 5 cm and used. A small amount of glass sprayer was used to spray a predetermined amount of an acetone solution of the reagent, or only acetone as a control, onto the carpet, and the carpet was air-dried for 3 hours. Medium 0.3 containing about 300 Dermatophagoides farinae on each carpet
g, and put it in a container adjusted to a relative humidity of about 65%,
It was placed in a temperature-controlled room at a temperature of 25 ± 1 ° C. For observation, the number of live mites was counted by the heat-discharging method using a hot plate. Each test was carried out in triplicate, and the growth inhibition rate was calculated from the number of live mites in the drug-treated group and the control group by the following formula. Further, the same test was performed on the carpet stored at 40 ° C. for one month after the chemical treatment. The results are shown in Table 2.

[0021]

[Table 2]

As a result of the test, the indoor miticidal mite agent of the present invention comprising only the glycol ether compound of the general formula I showed a high mite growth inhibitory effect. Further, it has been clarified that the compound A or the compound B which is a chitin synthesis inhibitor is added to this, and the residual effect is greatly improved. On the other hand, in the case of phenothrin which is a conventional indoor bactericidal dust mite agent, the test concentration was insufficient in both fast-acting and residual-acting.

[0023]

[Test Example 3] The central portion of the 5 cm × 5 cm carpet used in Test Example 2 was defined as a chemical-untreated section, and the outer circumference was 1 cm wide.
The chemical treatment was performed according to Test Example 2. However, the amount of the reagent agent to be treated was the amount with respect to the entire surface of the carpet of 5 cm × 5 cm. 0.2 g of a medium containing about 200 Dermatophagoides farinae was planted in a drug-free section in the center of the carpet,
Put in a container adjusted to about 65% relative humidity, temperature 25 ± 1
It was placed in a thermostatic chamber at 0 ° C. Table 3 shows the results of calculating the growth inhibition rate in the same manner as in Test Example 2.

[0024]

[Table 3]

As a result of the test, the glycol ether compound of the present invention also showed a high growth inhibitory effect on the carpet partially treated with the drug and planted with Dermatophagoides farinae in the drug-untreated area. Because it is poisonous but does not show repellent properties against mites. Therefore, when used in combination with compound A, it did not inhibit the action of compound A as a food poison, and the acaricidal effect was remarkably enhanced. On the other hand, the acaricidal effect of phenothrin was hardly recognized by the partial treatment method of this test. That is, it is presumed that phenothrin could not act as a contact poison because its repellent action prevented contact with mites. Also, as a matter of course, the mixture of phenothrin and compound A was not effective. Considering that it is not always possible to treat the entire surface uniformly in an actual treatment situation, the glycol ether compound of the present invention is effective even in the partial treatment, and by further mixing a chitin synthesis inhibitor such as compound A, the acaricidal effect can be enhanced. This is a very practical advantage.

[0026]

Example 1 0.6 g of ethylene glycol monobenzyl ether was dissolved in ethanol and filled in an aerosol container, and then a valve portion was attached, and a propellant was pressure-filled through the valve portion to obtain an aerosol (300 ml). 2 pieces of the above-mentioned aerosol was applied to a carpet of 10 cm square which was inoculated with about 300 mosquitoes and about 200 ticks.
After spraying ml (0.4 g / m ² as an active ingredient), the number of live mites was examined 2 weeks later, and it was found that the number of mites was 10 or less in each case.

[0027]

Example 2 An emulsion was prepared by adding a solvent (N-methylpyrrolidone) and the like to 50 parts of ethylene glycol monophenyl ether, 5 parts of compound A and 10 parts of an emulsifier. Dilute this emulsion 50 times with water and 70m on a carpet of 2 tatami mats.
1 (0.2 g / m ² as ethylene glycol monophenyl ether) was sprayed and dried. One month later, when about 500 Dermatophagoides farinae were inoculated, the proliferation of the mites was suppressed, and the habitat density eventually decreased to 5% or less of the initial level, showing a high preventive effect.

[0028]

INDUSTRIAL APPLICABILITY The indoor miticidal mite agent of the present invention has no repellency against indoor mite mites such as mites, leopard mites, and tick mites, and exhibits a high miticidal effect, while being highly safe for humans and animals. So extremely useful.

Further, according to the invention of claim 2, since a chitin synthesis inhibitor is mixed, in addition to the fast-acting acaricidal effect of the compound of the general formula I, the chitin synthesis inhibitor has a slow-acting mite growth effect. A suppressing effect can be imparted.

According to the invention of claim 3, since compound A, which is particularly useful among the chitin synthesis inhibitors, is added, an indoor dust-killing acaricide having a synergistic high acaricidal effect by both active ingredients can be obtained. You can Also, in this mixture, certain compounds of general formula I are useful as solvents for compound A.

─────────────────────────────────────────────────── ─── Continuation of the front page (58) Fields surveyed (Int.Cl. ⁷ , DB name) A01N 25/00-65/02

Claims (3)

(57) [Claims] 1. The general formula I: (In the formula, when m is an integer of 1 to 3 and n is 0, R ₁ represents a butyl group, a hexyl group, an octyl group, a benzyl group or a phenyl group, and R ₂ represents a hydrogen atom, a butyl group, a hexyl group. Group, octyl group, benzyl group or phenyl group, when m is 0 and n is an integer of 1 to 3, R ₁ represents a butyl group, a hexyl group or a phenyl group, and R ₂ represents a hydrogen atom. Further, when m is 2 and n is an integer of 2, R ₁ represents a butyl group or a hexyl group, and R ₂ represents a hydrogen atom.). An indoor dust mite agent. 2. The general formula I: (In the formula, when m is an integer of 1 to 3 and n is 0, R ₁ represents a butyl group, a hexyl group, an octyl group, a benzyl group or a phenyl group, and R ₂ represents a hydrogen atom, a butyl group, a hexyl group. Group, octyl group, benzyl group or phenyl group, when m is 0 and n is an integer of 1 to 3, R ₁ represents a butyl group, a hexyl group or a phenyl group, and R ₂ represents a hydrogen atom. Further, when m is 2 and n is an integer of 2, R ₁ represents a butyl group or a hexyl group, and R ₂ represents a hydrogen atom.), And a chitin synthesis inhibitor. The bactericidal indoor dust mite agent according to claim 1, which comprises: 3. The chitin synthesis inhibitor is N- (2-chlorobenzoyl) -N- [4- (2-chloro-4-trifluoromethyl-1-phenylmercapto) phenyl] urea. The indoor miticidal dust mite agent according to claim 2.