JPH07138112A - Indoor dusty acaricide - Google Patents

Abstract

PURPOSE: To obtain a miticide exhibiting high miticidal action on house dust mites such as acarid mite, Dermatophagoides farinae and Cheyletidae mite, harmless to man and beast and effective as a preventing agent as well as an eliminating agent for house dust mites. CONSTITUTION: This miticide for house dust mites contains N-(2-chlorobenzoyl)-N '-[4-(2-chloro-4-trifluoromethyl-1-phenylmercapto)phenyl]urea.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an indoor dust containing N- (2-chlorobenzoyl) -N '-[4- (2-chloro-4-trifluoromethyl-1-phenylmercapto) phenyl] urea. It concerns a sex tick agent.

[0002]

2. Description of the Related Art A great variety of mites live on the earth, and for example, citrus spider mites and worm spiders parasitic on plants cause great damage to agricultural products. Acaricides for the purpose of agricultural use against these mites have been developed for a long time, and recently new promising compounds have been discovered one after another. On the other hand, in recent years, due to changes in the living environment, indoor dust mites such as mites, leopard mites, and tick mites occur, which not only causes discomfort, but also causes problems such as causing allergic asthma and skin rashes. . It is known that organophosphorus agents such as Sumithion and diazinon, and pyrethroid agents such as phenothrin and permethrin show effects on indoor dust mites that occur indoors, but insecticides with these acaricidal effects. Since all of the components are contact poisons, contact between the drug and ticks is essential. That is, in order to uniformly treat the drug on the entire surface of the carpet where mites inhabit, for example, it is necessary to spray a large amount, and the treatment method is very difficult, and at the same time, from the concern of safety for humans, especially for children. The current situation is that it is not practical. In addition, indoor dust mites are generally vulnerable to heat,
Physical mite control methods such as high-frequency heat treatment of tatami mats and carpets and futon drying are also effective, although they die almost completely in a few minutes at ℃ and cannot grow in a dry state. In that respect, there are major obstacles, and it is earnestly desired to establish an accurate method of extermination.

[0003]

SUMMARY OF THE INVENTION In view of the above situation, the present invention has been made with the object of developing an indoor slaughterhouse dust mite agent that can be safely used indoors.

[0004]

[Means for Solving the Problems] To achieve the above object, the inventors of the present invention conducted extensive studies and found that N- (2-
Chlorobenzoyl) -N '-[4- (2-chloro-4-
A composition containing trifluoromethyl-1-phenylmercapto) phenyl] urea was found to show a high acaricidal effect against indoor dust mites such as mites, deer mites, and tick mites, and further research has been conducted. Completed the invention. That is, the present invention provides N- (2-chlorobenzoyl) -N '-[4- (2-chloro-4-trifluoromethyl-1-phenylmercapto) phenyl] urea (hereinafter referred to as compound A). The present invention relates to an indoor bactericidal dust mite agent characterized by containing.

Incidentally, the compound A corresponds to a benzoylurea compound known as an inhibitor of chitin biosynthesis in insects and mites, and is disclosed in JP-A-2-270.
It is disclosed that various insect pests such as mosquitoes, flies, and cockroaches and mites attached to plants exhibit high insecticidal and acaricidal effects. However, its effect on indoor dust mites remained unclear.

Although the benzoylurea compounds such as diflubenzuron and teflubenzuron which have been developed so far show high insecticidal and acaricidal activity against hygienic pests such as mosquitoes, flies and cockroaches and spider mites attached to plants, Shows little effect on indoor dust mites. This is thought to be due to the morphological difference that the house dust mites belonging to plants belong to the aerial phylum, whereas the indoor dust mites belong to the aerial phylum. Therefore, initially, the activity of the compound A against indoor dust mites could not be predicted at all.

However, while the conventional organophosphorus agents and pyrethroid agents act as neurotoxins, the present inventors have found that the site of action of inhibitors of chitin biosynthesis is chitin, which is peculiar to insects and mites. Since it is almost harmless to benzoylurea compounds, we considered that benzoylurea compounds were the most suitable active ingredients for indoor dust mites, and screened various compounds of this system. As a result, they have found that, unlike other benzoylurea-based compounds, only compound A specifically shows a high acaricidal effect on indoor dust mites, which led to the present invention.

Compound A used in the present invention is disclosed in
-270 is easily manufactured according to the synthetic method described in the gazette, and is a solid at room temperature. When the compound A is used as an active ingredient of the indoor miticidal mite agent of the present invention, it may be used as it is without adding any other component, but it may be used as a solid carrier, a liquid carrier, a gaseous carrier, an interface. It is generally used by mixing with an active agent, other auxiliary agents for formulation, feed, etc., and formulated into powders, granules, aerosols, emulsions, water solutions, smoke agents, poison baits, sheets and the like.

Examples of solid carriers include clays (kaolin, bentonite, etc.), talcs, silicas, alumina powder, activated carbons, plant powders, and the like, and liquid carriers include, for example, water and alcohols (methyl alcohol). , Ethyl alcohol, ethylene glycol, etc.), ketones (acetone, methyl ethyl ketone, cyclohexanone, etc.), ethers (ethyl ether, dioxane, cellosolves, etc.), aliphatic hydrocarbons (gasoline, kerosene, kerosene, etc.), aromatics Suitable solvents include hydrocarbons (benzene, toluene, xylene, methylnaphthalene, etc.), halogenated hydrocarbons (dichloromethane, trichlorobenzene, etc.), esters, acid amides, nitriles, etc., and one of these. Alternatively, a mixture of two or more can be used. In addition, there are LPG (liquefied petroleum gas), dimethyl ether, flon gas, etc. as the gaseous carrier, and as the surfactant, alkyl sulfate ester salt, alkyl sulfonate, polyoxyethylene alkyl ether, sorbitan fatty acid ester, polyoxyethylene poly Any commonly available substance such as oxypropylene block polymer may be used. Furthermore, as the formulation auxiliary agent, a dispersant, a sticking agent, a stabilizer, etc. are appropriately used.

The indoor dust-eliminating mites of the present invention include compound A
Other acaricides, insecticides, bactericides, repellents, synergists, mildew-proofing agents, growth regulators, flavoring agents, coloring agents, etc. to obtain a multipurpose composition unless it inhibits the activity of You can also For example, as insecticides fenitrothion, diazinon, organophosphorus agents such as propetanphos, phenothrin, permethrin, resmethrin, etofenprox, pyrethroid agents such as empentrin, silafluofen,
Examples thereof include compounds such as diflubenzuron, teflubenzuron, chlorfluazuron, flufenoxuron and pyriproxyfen. Further, N, N-diethyl-m-toluamide, benzylbenzoate and the like are used as repellents, and piperonyl butoxide, octachlorodipropyl ether, N- (2-ethylhexyl) -bicyclo [2. 2.1] Hepta-5-ene-2,3-dicarboximide, isobornyl thiocyanoacetate and the like can be exemplified.

The amount of the active ingredient and the amount of the active ingredient used in the indoor dust-removing mite agent of the present invention are as follows:
It is appropriately determined according to the application place and the like. For example, it is preferable that 0.1 mg or more of the compound A is applied per 1 m ^{2 for} the control of deer spider mites and the like that inhabit carpets. Further, since compound A acts not only as a contact poison but also as a food poison, a poison bait agent mixed in feed or the like is a useful use form. In this case, 0.1 ppm to 1.0% is sufficient. The effect is obtained. Further, Compound A has a feature that it can exhibit a high acaricidal effect not only by the uniform treatment on the entire surface but also by the partial treatment because of the dual action of contact poison and food poison. on the other hand,
Conventional organophosphorus agents and pyrethroids act only as contact poisons and repel a lot of indoor dust mites, so partial treatment does not provide an acaricidal effect.

[0012]

As described above, the indoor miticidal mite agent of the present invention exhibits a high miticidal effect against indoor mite dust mites such as mites, deer mites and claw mites, and is extremely safe for humans and animals. The present invention provides an accurate method for treating a drug, which is an alternative to the conventional method using an organic phosphorus agent or a pyrethroid agent. In addition, since Compound A is chemically stable and has a good residual effect, this agent is extremely useful not only as a disinfection treatment after the occurrence of indoor dust mites, but also as a so-called preventive treatment agent that pre-treats carpets, duvets, etc. It is useful.

[0013]

EXAMPLES The present invention will be described in more detail with reference to test examples and examples, but the present invention is not limited to the following examples as long as the gist thereof is not exceeded. Test Example 1 A reagent medium was mixed with powder feed for experimental animals to prepare a medium having a predetermined double concentration. A breeding medium containing mites was thoroughly mixed with this medium at a ratio of 1: 1 to obtain a treated medium having a predetermined concentration. In addition, the mite density of the treatment medium was set at about 450 mosquitoes of Pleurotus cornucopiae and about 100 of Mite mosquitoes. Similarly, a non-treated medium was prepared, and 5 g of each of these test mediums was placed in a Petri dish having a diameter of 4.5 cm and a height of 1.5 cm.
Approximately 65%, and in the case of Physcomitrella patens, it was placed in a container adjusted to approximately 85% and reared in a thermostatic chamber at a temperature of 25 ± 1 ° C. The observation was carried out two and three weeks after the treatment by lightly stirring the medium to uniformly disperse the mites in the test medium, weighing 0.1 g from each test medium, and counting the number of live mites under a stereomicroscope.
The test was weighed three times from each test section, and the growth inhibition rate after 2 weeks and 3 weeks after the treatment was calculated from the average value by the following formula. The results are shown in Table 1. Growth inhibition rate (%) = [{(number of live mites in untreated plot)-(number of live mites in treated plot)} / (number of live mites in untreated plot)] × 10
0

[0014]

[Table 1]

As a result of the test, the compound A showed a very high growth inhibitory rate at a low concentration in the method of feeding after being mixed in the medium, against the house dust mite and the mite. In contrast, other benzoylurea compounds such as diflubenzuron and teflubenzuron used as controls, juvenile hormone agents such as methoprene and pyriproxyfen had almost no growth inhibitory effect, and had acaricidal activity against indoor dust mites. It was revealed that is a characteristic specific to Compound A among the benzoylurea compounds. On the other hand, the pyrethroid agent phenothrin, which is mainly used as an active ingredient of conventional indoor dust mite agents, required a high concentration to exhibit acaricidal activity. Therefore, compound A, which is almost harmless to humans and animals in terms of mechanism of action, and has extremely high acaricidal activity at low concentration, replaces conventional active ingredients such as phenothrin and provides a very useful indoor dust-carrying acaricide. It is a thing.

Test Example 2 As a test carpet, a commercially available carpet (wool 10
0%, no wool mark, cut type, pile length 7m
m) was used after being cut into a size of 5 cm × 5 cm. To this carpet, using a small glass sprayer, an acetone solution of the reagent agent is added at 20 mg or 100 mg per 1 m ^2.
As a control, only acetone was sprayed and air dried for 3 hours. On each carpet, 0.5 g of a medium containing about 450 mosquitoes was planted, placed in a container adjusted to a relative humidity of about 65%, and placed in a temperature-controlled room at a temperature of 25 ± 1 ° C. For observation, the number of live mites was counted by the heat-discharging method using a hot plate. Each test was carried out in triplicate, and the growth inhibition rate was calculated from the number of live mites in the drug-treated group and the control group by the following formula. Further, the same test was carried out on a carpet stored at 40 ° C. for one month after the chemical treatment. The results are shown in Table 2.
Shown in. Growth inhibition rate (%) = [{(number of live mites in control area)
-(Number of live mites in chemical treatment area)} / (Number of live mites in control area)] x 100

[0017]

[Table 2]

As a result of the test, even in a so-called preventive treatment in which the carpet is preliminarily treated with a chemical, the compound A shows a very high growth inhibitory rate at a low concentration and has excellent weather resistance, so that it can be used indoors such as carpets and futons. It was confirmed to be extremely useful as a dust mite preventive treatment agent. Similar effects were not observed with other benzoylurea compounds such as diflubenzuron and teflubenzuron.

Test Example 3 The central portion of the 5 cm × 5 cm carpet used in Test Example 2 was set as a chemical untreated section, and the outer peripheral 1 cm width was treated with the chemical according to Test Example 2. However, the processing amount of the reagent is 5c
It is the amount for the entire surface of the m × 5 cm carpet. 0.2 g of a medium containing about 200 mosquito deer mosquitoes was planted on the chemical-untreated section in the center of the carpet, placed in a container adjusted to a relative humidity of about 65%, and placed in a temperature-controlled room at a temperature of 25 ± 1 ° C. Table 3 shows the results of calculating the growth inhibition rate in the same manner as in Test Example 2.

[0020]

[Table 3]

As a result of the test, the compound A showed a high acaricidal effect even on the carpet partially treated with the drug and planted with the house dust mite mite-treated area. It is considered that this is based on the property of compound A that compound A does not exhibit repellent properties and acts not only as a contact poison but also as a food poison. On the other hand, the pyrethroid agent phenothrin showed a certain degree of acaricidal effect in the entire uniform treatment method at this concentration, but in the partial treatment method of this test,
Almost no acaricidal effect was observed. That is, it is presumed that the repellent property of phenothrin hindered contact with mites and could not act as a contact poison. Considering that it is not always possible to treat the entire surface uniformly in an actual treatment scene, it can be said that Compound A is effective even in the partial treatment, which is a very practical advantage.

Example 1 0.7 g of Compound A was dissolved in ethanol and filled in an aerosol container, and then a valve portion was attached, and a propellant was pressure-filled through the valve portion to obtain an aerosol (300 ml). 30ml of the above aerosol on a carpet of 2 tatami mats
After spraying (20 mg / m ² as an active ingredient) and inoculating about 500 Kata leopard mite one month later, the growth of mites was suppressed, and the habitat density was reduced to 5% or less of the initial time, and a high preventive effect was observed. .

Example 2 0.1 g of compound A, 0.2 g of N- (2-ethylhexyl) -bicyclo [2.2.1] hept-5-ene-2,3-dicarboximide and 99.7 g of powdered feed. The mixture was thoroughly pulverized and mixed to obtain a poison veterinary preparation. About 20 g of the adjusted poison bait was sprayed at a rate of 20 g per 1 m ² (20 mg / m ² as an active ingredient) on a 10 cm square carpet inoculated with about 300 blemishes and about 200 mites, and the number of living mites was examined 2 weeks later. However, in all cases, the number was reduced to 10 or less.

[0024]

INDUSTRIAL APPLICABILITY As described in detail above, the indoor miticidal mite agent of the present invention exhibits a high acaricidal activity against indoor mite mites such as mites, leopard mites, and tick mites,
Moreover, its safety is far superior to that of conventional drugs, and therefore its practicality is extremely high.

 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Hans Schubert 7-4-35 Oi, Shinagawa-ku, Tokyo

Claims (1)

[Claims] 1. N- (2-chlorobenzoyl) -N'-
[4- (2-chloro-4-trifluoromethyl-1-phenylmercapto) phenyl] urea is contained, which is an indoor dust-killing agent.