KR100819691B1 - Composition for control of Dust Mite - Google Patents

Abstract

The present invention contains any one active ingredient selected from the group consisting of Cinnamon extract, Cinnamic aldehyde, Tea-Tree oil or a mixture of two or more thereof, and a volatile solvent as a solvent. The present invention relates to a composition for combating house dust mites, which is easy to use because it has excellent human safety and insecticidality when produced in a predetermined dosage form and no residue is generated when spraying or applying, and the cinnamon extract and cinnamic acid aldehyde based on the total weight of the composition , Tea tree oil or any one selected from the group consisting of two or more of these active ingredients, characterized in that it comprises 0.1 to 30.0% by weight of the active ingredient and the remaining amount of ethanol or ethanol aqueous solution as a volatile solvent.

Dust mite, cinnamon, tea tree oil, volatile solvent

Description

Composition for controlling dust mite {Composition for control of Dust Mite}

1 is a graph showing the insecticide change according to the insecticide time of Preparation Examples 1 to 3 and Comparative Preparation Example 1 of the present invention.

2 is a graph showing the insecticide change according to the insecticide time of Preparation Example 3 and Comparative Preparation Example 3 of the present invention.

The present invention relates to a composition for combating house dust mite that acts as a major cause of allergic diseases in a residential space, and more particularly, Cinnamon extract, Cinnamic aldehyde, Tea-Tree oil or these. It contains any one of the active ingredients selected from the group consisting of two or more mixtures, and by using a volatile solvent as a solvent it is excellent in human safety and insecticidality when prepared in a predetermined dosage form, no residue is generated when spraying or applying The present invention relates to a composition for combating dust mites.

Bedding, beds, sofas, and carpets placed in residential spaces are suitable for house dust mite breeding, so the human skin skin becomes the main food source for house dust mites. It is easily dispersed in the middle, and has been a cause of pediatric asthma, dermatitis and allergic disease.

House dust mites living and multiplying in a residential space have a size of about 0.3㎜, and the major species are Dermatophagoides farinae and vertical mites ( Der).

matophagoides pteronyssinus ). The direct cause of allergens caused by house dust mites was found not to be house dust mites themselves but to the excretion of house dust mites or to the decomposition of dead individuals.

In order to prevent allergy caused by house dust mite, ultimately, a method of blocking house dust mite-related substances by covering a house dust mite prevention cover on a bedding or a bed in order to prevent house dust mite excretion or decomposition products is used. However, it was expensive, temporary, and inconvenient to use, but could not directly obtain house dust mites.

 Thus, in order to prevent the generation of feces or decomposition products that are a direct cause of this, research has been made on methods of suppressing the growth of house dust mites themselves, and researches on methods using chemicals have been made in particular.

Pesticides prepared by applying chemicals include organophosphorus insecticides, carbamite insecticides, pyrethroid insecticides, and the like.

Of these, organophosphorus and carbamite insecticides have high insecticidal properties selectively to cold-blooded animals such as insects and are a problem in human safety.                         

On the other hand, pyrethroid-based insecticides are relatively safe for the human body and are being used a lot, but because of the image of 'pesticides', consumers are avoiding using dust mites, such as bedding, sofas and carpets. In addition, pyrethroid-based insecticides are mostly used in aerosol formulations, and in the case of products using kerosene as a solvent component that solubilizes the insecticides in the aerosol, the solvent is not easily volatilized after spraying, leaving stains on the floor and spraying on a bed or a blanket There is a problem that the residue remains when the, the product using the silica gel as a solvent component has the advantage of low toxicity, but this also has a problem that it is difficult to directly process the bedding, such as solid residue remains during spraying.

Accordingly, the present invention is provided to solve the problems of the prior art as described above more efficiently, the object of which is the main ingredient as a natural ingredient Cinnamon (Cinnamon) extract, Cinnamic aldehyde (Cinnamic aldehyde), Tea-Tree (Tea-Tree) It contains an active ingredient selected from the group consisting of oil or a mixture of two or more of them, and by using a volatile solvent as a solvent, it is excellent in human safety and insecticidality when manufactured in a predetermined dosage form, and residues when spraying or applying It is to provide a composition for combating dust mites easy to use because it does not occur.

In order to achieve the above object, the composition for combating dust mites according to the present invention is selected from the group consisting of Cinnamon extract, Cinnamic aldehyde, Tea-Tree oil or a mixture of two or more thereof. 0.1 to 30.0% by weight of any one of the active ingredient and a volatile solvent, characterized in that it comprises ethanol or an aqueous solution of ethanol in the remaining amount.

Hereinafter, the present invention will be described in detail.

The composition for combating house dust mite of the present invention contains cinnamon extract, cinnamic acid aldehyde and tea tree oil as main components, and a volatile solvent is used as a solvent for solubilizing them.

Cinnamon generally refers to cinnamon of camphor tree, and conventional cinnamon oil (cinnamon oil) is an aromatherapy ingredient that has been used for the treatment of weakness, depression, epidemic colds, and pain in insect bites. None used. Cinnamic aldehyde accounts for about 70% to 90% of the total content of cinnamon, which has a direct effect on the insecticidal effect of house dust mites. In the case of the present invention, after crushing the leaves, buds or bark of cinnamon, the cinnamon extract obtained by distilling and extracting with water vapor at high temperature and reduced pressure and then cooling is used as a main component for combating house dust mites.

In addition, in addition to the cinnamon extract, only cinnamic aldehyde (Cinnamic aldehyde) stock solution, which is a direct component having a pesticidal effect in the cinnamon extract, may be separately extracted and used by distillation.

Tea-Tree oil, which is another main ingredient of the present invention, is a native of Australia as a drinking tea (Camellia Tea) and is extracted using mainly leaves. It has been used as a deodorant, disinfectant and air purifier, but it has not been used as an insecticide component of house dust mites. In the case of the present invention, the leaves of the tea tree (Tea-Tree) are pulverized, and then the tea tree oil obtained by distillation and extraction with water vapor under high temperature and reduced pressure is cooled. The cinnamon extract, cinnamic acid aldehyde, tea tree oil may be used alone or in combination.

As the solvent for dissolving the above pesticidal components in the present invention, volatile solvents such as ethanol and ethanol aqueous solution may be used.

Hereinafter will be described in detail the effect of the composition for combating dust mites of the present invention according to such a configuration.

Meanwhile, any one active ingredient selected from the group consisting of Cinnamon extract, Cinnamic aldehyde, Tea-Tree oil, or a mixture of two or more thereof of the present invention has a direct effect on house dust mite insecticidal properties. As a component that represents, there is a problem that the insecticide is not well used when used in an amount of less than 0.1% by weight based on the total weight of the composition, there is an uneconomical problem when used in an amount greater than 30.0% by weight. Accordingly, any one of the active ingredients selected from the group consisting of Cinnamon extract, Cinnamic aldehyde, Tea-Tree oil, or a mixture of two or more thereof is 0.1 based on the total weight of the composition. Preference is given to using in amounts of from 30.0% by weight.

As the solvent of the present invention, a volatile solvent is preferable, and it is more preferable to use ethanol or an ethanol aqueous solution. Since these solvents are volatile solvents, they do not leave any residue when they are used, and they do not have the effect of killing house dust mites, which are micropests, but have a knock-down effect that temporarily stuns pests. It is effective to let.

Pesticides of various formulations such as spraying, coating or aerosol can be prepared using the composition for combating dust mites containing the above-mentioned ingredients and solvents. As a propellant for the dual aerosol formulation, one or more components selected from liquefied natural gas, dimethyl ester, compressed air, and compressed nitrogen may be used. At this time, when the amount of the dust mite extinguishing composition: propellant is out of the volume% of 70:30 to 30:70, there is a problem that the injection state of the composition is poor or the remaining amount, the volume of 70:30 to 30:70 It is preferable to use in%.

Hereinafter, the composition for combating dust mites will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited to these examples.

Example 1

Cinnamon leaf, bud or bark is crushed, and then distilled and extracted with water vapor, and the resulting cinnamon extract is taken in an amount of 3.0% by weight based on the total weight of the composition and dissolved in the remaining amount of ethanol aqueous solution to combat dust mites. A composition for preparation was prepared.

Example 2

After crushing the leaves of Tea-Tree, distilled and extracted with water vapor, the obtained tea tree oil was taken in an amount of 3.0% by weight based on the total weight of the composition and dissolved in the remaining amount of ethanol aqueous solution to remove the house dust mite composition. Prepared.

Example 3

1.5% by weight of the cinnamon extract of Example 1 and 1.5% by weight of the tea tree oil of Example 2 were dissolved in an amount of ethanol aqueous solution to prepare a composition for combating dust mites.

Comparative Example 1

Phenothrin, a pyrethroid insecticide, was added in an amount of 0.078% by weight and 0.444% by weight based on the total weight of the composition, and dissolved in an ethanol aqueous solution to prepare a composition for combating dust mites.

Comparative Example 2

Cinnamon leaf, bud or bark is crushed, and then distilled and extracted with water vapor, and then cooled by taking the amount of cinnamon extract in an amount of 3.0% by weight based on the total weight of the composition and dissolved in the residual amount of kerosene to combat dust mites The composition was prepared.

Hereinafter, the present invention will be described in more detail with reference to production examples, but the present invention is not limited only to these examples.

[Production Example 1]

An aerosol was prepared according to a conventional method using a mixed solution obtained by mixing a natural liquefied petroleum gas in an amount of 40% by volume as a propellant to 60% by volume of the composition of Example 1.                     

[Production Example 2]

An aerosol was prepared according to a conventional method using a mixed solution obtained by mixing a natural liquefied petroleum gas in an amount of 40% by volume as a propellant to 60% by volume of the composition of Example 2.

[Production Example 3]

An aerosol was prepared according to a conventional method using a mixed solution in which natural liquefied petroleum gas was mixed in an amount of 40% by volume as a propellant to 60% by volume of the composition of Example 3.

[Comparative Production Example 1]

An aerosol was prepared according to a conventional method using a mixed solution in which a natural liquid petroleum gas was mixed in an amount of 40% by volume as a propellant to 60% by volume of the composition of Comparative Example 1.

[Comparative Production Example 2]

An aerosol was prepared according to a conventional method using a mixed solution obtained by mixing a natural liquefied petroleum gas in an amount of 40% by volume as a propellant to 60% by volume of the composition of Comparative Example 2.

[Comparative Production Example 3]

An aerosol was prepared according to a conventional method using a mixed solution in which natural liquefied petroleum gas was mixed in an amount of 40% by volume as a propellant to 60% by volume of ethanol.

[Test Example 1]

In order to prevent the dust mites from flying by the injection pressure during the injection, after receiving the stock solution of Preparation Examples 1 to 3 and Comparative Preparation Example 3 in a beaker in advance immediately before the experiment, put a cotton cloth on the bottom of a 5 cm watch plate 25 mites ( Dermatophagoides pteronyssinus ) were bred on cotton fabrics at 25 ° C breeding temperature and 80% relative humidity. Subsequently, 50 µl of the stock solution, which is an amount suitable for observing the insecticidal action of house dust mites, was evenly spread over the ethanol properties as a solvent and the cotton cloth laid on the floor, and immediately dropped onto each watch plate using a micropipette. The insecticide change with time to pesticide was measured to move to, and the results are shown in Figure 1 and Table 1 below.

0 min 1 minute 2 minutes 4 minutes 8 minutes 12 minutes 20 minutes 30 minutes Preparation Example 1 0 0 0 25 54 80 94 100 Preparation Example 2 0 0 0 0 0 19 53 100 Preparation Example 3 0 0 21 68 87 100 100 100 Comparative Production Example 3 0 0 0 8.3 11 11 11 11

In Fig. 1,? Indicates Preparation Example 1,? Indicates Preparation Example 2,? Indicates Preparation Example 3, and? Indicates Comparative Measurement Example 3. FIG.

As can be seen in Figure 1 and Table 1, compared with the pesticide using only ethanol of Comparative Preparation Example 3, the pesticides of Preparation Examples 1 to 3 were excellent in insecticide. In addition, when the same content was used, it can be seen that Preparation Example 1 containing cinnamon components showed better insecticidal properties than Preparation Example 2 containing tea tree oil components.

[Test Example 2]

Except for using only the stock solution of Preparation Example 3 and Comparative Preparation Example 1 as the stock solution was measured pesticide rate according to the insecticide time under the same conditions as in Test Example 1, the results are shown in Figure 2 and Table 2 It was.

0 min 1 minute 2 minutes 4 minutes 8 minutes 12 minutes 20 minutes 30 minutes Preparation Example 3 0 0 23 73 92 100 100 100 Comparative Production Example 1 0 0 0 22 50 56 94 100

In Figure 2, ● indicates Production Example 3 and ■ measurement results of Comparative Production Example 1.

As can be seen in Figure 2 and Table 2, the pesticide of Preparation Example 3 using a mixture of cinnamon and tea tree oil compared to the conventional chemical insecticide using phenotrine and phthaline of Comparative Preparation Example 1 The insecticide was much better.

[Test Example 3]

When the aerosols of Preparation Example 1 and Comparative Preparation Example 2 were used in beds, sofas, carpets, and the like, the general public was evaluated for 40 people, and the average of the evaluation results is shown in Table 3 below.

Satisfaction with Use Preparation Example 1 4.2 Comparative Production Example 2 2.3

* Satisfaction Evaluation Criteria:

5-very satisfied, 4-satisfied, 3-normal, 2-satisfied, 1-very dissatisfied

As can be seen in Table 3, Preparation Example 1 using ethanol as a solvent can be seen that the use satisfaction is superior to Comparative Preparation Example 2 using kerosene as a solvent.

As can be seen from the above, the composition for combating dust mites of the present invention is a group consisting of cinnamon extract, cinnamic aldehyde, tea-tree oil or a mixture of two or more thereof as an insecticidal component. By using any one of the active ingredients selected from, and using a volatile solvent as a solvent, it is excellent in human safety and insecticidal properties and do not generate residue when spraying or applying can be prepared and used as a pesticide of various formulations.

Claims (1)

0.1 to 30.0% by weight of an active ingredient consisting of Tea-Tree oil alone or a mixture of Tea-Tree oil and Cinnamon extract or Cinnamic aldehyde, and ethanol or an ethanol aqueous solution as a volatile solvent. House dust mite fighting composition comprising the remaining amount.

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