JP6086815B2 - Indoor mite repellent efficacy enhancer and indoor mite repellent method using the same - Google Patents

Description

The present invention relates to an indoor mite repellent efficacy enhancer and an indoor mite repellent method using the same.

In recent years, due to changes in the living environment, indoor dust mites such as mites, leopard mites, dust mites, etc. have been generated indoors, causing problems such as allergic asthma and skin eruption as well as discomfort. .
Therefore, there has been a demand for indoor acaricides for treating carpets and bedding, but because there are many use cases where they are in direct contact with the skin indoors, development of safer drugs is still necessary. The exact control method is not established. Furthermore, it has been clarified that leopard mites that cause allergic asthma can cause allergies even in the corpse itself.

Against this background, a technique for preventing tick from approaching people and patients rather than killing indoor dust mites has been sought, and several proposals have been made so far. For example, Patent Document 1 (Japanese Patent Application Laid-Open No. 3-264504) discloses an acaricide or a tick repellent containing n-hexyl salicylate, n-hexyl benzoate, eugenol, or the like as an active ingredient. Patent Document 2 (Japanese Patent Laid-Open No. 6-16515) discloses plant essential oils such as vetiver oil, patchouli oil, clove oil, and the like as Patent Document 3 (Japanese Patent Laid-Open No. 2001-2001). No. 31508) discloses 1,8-cineole or eucalyptus oil containing a large amount of this component, and is conscious of natural product orientation and safety, but has a satisfactory repellent effect on indoor dust mites. I can't say that.

On the other hand, the present inventors have previously found that cinnamic acid derivatives such as cinnamyl acetate and methyl cinnamate are useful as a tick repellent component, and disclosed Patent Document 4 (Japanese Patent Laid-Open No. 2006-89424) relating to an aqueous solution. I applied. And, as a preferable application example of this preparation, a liquid absorption core type indoor dust mite control product comprising a liquid absorption core that sucks up an aqueous liquid agent and an evaporation part that is located above the liquid absorption core and diffuses the liquid solution sucked up. Presented. This tick control product can create a space that tick dislikes by the volatilization action of cinnamic acid derivatives, but it is highly practical, but it is used for applications that expect residual effect by attaching the mite repellent component to the object Is not suitable.
Furthermore, the present inventors have disclosed in Patent Document 5 (Japanese Patent Laid-Open No. 2011-132196) that “a stock solution and a propellant containing a non-volatile tick repellent component and a solvent are contained in an indoor dusty mite from their filled containers. A method of spraying a certain amount toward a space above a place where the mosquitoes are inhabiting or inhaling, and the spray particles settle and adhere to the place, thereby repelling the indoor dust mites '' While disclosed, it was suggested that dibasic acid esters are preferable as the non-volatile tick repellent component, and dibutyl sebacate is the most suitable, but there is still room for improvement in terms of indoor mite repellent efficacy.

JP-A-3-264504 Japanese Patent Laid-Open No. 6-16515 JP 2001-31508 A JP 2006-89424 A JP 2011-132196 A

The present invention is an indoor tick repellent composition which is blended in an indoor tick repellent composition containing a specific indoor tick repellent component and can remarkably enhance the indoor mite repellent efficacy of the indoor tick repellent component with respect to mite, leopard mite, dust mite, claw mite and the like. An object of the present invention is to provide a repellent efficacy enhancer and an indoor mite repellent method using the same.

The present invention has been found that the following constitution has an excellent effect for achieving the above-mentioned object.
(1) Octyl caprylate, butyl caprate, heptyl caprate, isopropyl laurate, propyl laurate, butyl laurate, isopropyl myristate, propyl myristate, butyl myristate, isopropyl palmitate, heptyl palmitate, isopropyl stearate An aliphatic carboxylic acid ester compound selected from the group consisting of isopropyl isostearate, ethyl linoleate, and isopropyl linoleate, and one selected from cyclohexyl benzoate and benzyl benzoate Or the indoor tick repellent efficacy enhancer mix | blended with the indoor tick repellent composition which contains 2 or more types as an indoor tick repellent component.
(2) An indoor tick repellent method in which the indoor tick repellent composition containing the indoor tick repellent efficacy enhancer according to (1) is treated indoors.
(3) The indoor mite repellent method according to (2), wherein the indoor mite repellent composition is subjected to a certain amount of space spray treatment using an aerosol agent provided with an aerosol valve for quantitative spraying.

The indoor mite repellent efficacy enhancer of the present invention is blended in an indoor mite repellent composition containing a specific indoor mite repellent component, and the indoor mite repellent efficacy of the indoor mite repellent component against mite, leopard mite, dust mite, claw mite, etc. Can be remarkably enhanced, so it is very useful. And the indoor tick repellent method using this is also very practical.

In the present invention, as an indoor mite repellent component, salicylic acid ester compounds and / or compounds that are relatively effective for indoor mites such as acarid mites, leopard mites, dust mites, claw mites, etc., are highly safe for human livestock, and have an appropriate residual effect. A benzoic acid ester compound is used.
Many of such indoor mite repellent components are known compounds disclosed in Patent Document 1 (Japanese Patent Application Laid-Open No. 3-264504), but by themselves, the indoor mite repellent efficacy is not always sufficient (note that cyclosalicylate cyclo For alkyl and cycloalkyl benzoates, there is no literature describing their indoor mite repellent efficacy).
However, the present inventors have found that these indoor mite repellency components can significantly increase the indoor mite repellency efficacy by combining with an indoor mite repellency enhancement agent described later, and have achieved the present invention. It is a thing.

Examples of the salicylic acid ester compounds include amyl salicylate, isoamyl salicylate, hexyl salicylate, cyclohexyl salicylate, cis-3-hexenyl salicylate, and benzyl salicylate. The benzoic acid ester compounds include amyl benzoate, Examples include isoamyl benzoate, hexyl benzoate, cyclohexyl benzoate, cis-3-hexenyl benzoate, and benzyl benzoate. Among these compounds, hexyl salicylate, cyclohexyl salicylate, benzyl salicylate, and cyclohexyl benzoate are preferable from the viewpoint of indoor mite repellent efficacy and effects on resins and the like, and cyclohexyl salicylate and cyclohexyl benzoate are particularly preferable.

The compounding amount of the salicylic acid ester compound and / or the benzoic acid ester compound varies depending on the form of the preparation, but is suitably about 0.1 to 50% by mass relative to the total amount of the indoor mite repellent composition. If it is less than 0.1% by mass, the desired effect cannot be obtained. On the other hand, if it exceeds 50% by mass, the liquid property of the indoor mite repellent composition may be problematic. In addition, when geometrical isomers and optical isomers are present in the compound, it goes without saying that each of them and any mixture thereof are also included in the present invention.

The present invention combines the indoor mite repellent component with a specific indoor mite repellent efficacy enhancer, specifically, an aliphatic carboxylic acid ester compound in which the total number of carbon atoms in the acid portion and the alcohol portion is 14-23. Is characterized in that the indoor mite repellent effect of the indoor mite repellent component is specifically and significantly enhanced.
Examples of the aliphatic carboxylic acid ester compounds include octyl caprylate, butyl caprate, heptyl caprate, isopropyl laurate, propyl laurate, butyl laurate, isopropyl myristate, propyl myristate, butyl myristate, isopropyl palmitate, Examples include heptyl palmitate, isopropyl stearate, isopropyl isostearate, ethyl linoleate, and isopropyl linoleate. Among them, myristic acid esters are preferable, and among them, isopropyl myristate is excellent in enhancing effect and easy to use.

The aliphatic carboxylic acid ester compound has heretofore been generally used as a solvent for insecticides, but no attention has been paid to its relevance to indoor mite repellent efficacy. However, as a result of intensive studies, the present inventors confirmed that the aliphatic carboxylic acid ester compound having a total number of carbon atoms of the acid part and the alcohol part of 14 to 23 exhibits a corresponding indoor mite repellent effect, Furthermore, the inventors have found that the synergistic effect with the indoor mite repellent component is more remarkable than expected, and have achieved the present invention.
The mixing ratio of the aliphatic carboxylic acid ester compound to the indoor mite repellent component is 0.5 to 60 times, preferably about 1.0 to 30 times. If it is less than 0.5 times, the desired synergistic effect cannot be obtained. On the other hand, even if it exceeds 60 times, the synergistic effect corresponding to the blending amount is not always achieved.

In the present invention, other indoor mite repellent components and indoor tick repellent components may be blended as long as they do not hinder the gist of the present invention. Examples of such components include cinnamic acid derivatives (cinnamyl acetate, methyl cinnamate, benzyl cinnamate, cinnamaldehyde, cinnamon oil, etc.), heliotropin, p-anisaldehyde, m-anisaldehyde, perilaldehyde, eugenol, isoeugenol. Indoor mite repellent components such as dihydroeugenol, eugenyl acetate, dibutyl sebacate, diethyl phthalate, and diethyl toluamide (diet), and indoor tick control components such as phenothrin, amidoflumet, and isobornyl thiocyanoacetate can give.

The indoor mite repellent composition used in the present invention is further, if necessary, other functional components (insecticide component, antifungal component, antibacterial component, bactericidal component, deodorant component, etc.), solvent, propellant, surfactant, Solubilizers, dispersants, mite allergen reducing agents, clothing protective agents such as cyclic silicones, stabilizers, colorants, fragrance ingredients, etc. are appropriately blended, and dosage forms such as liquids, emulsions, aqueous solvents, aerosols, etc. Generally, it is prepared.

Insecticidal components include, for example, allethrin, praretrin, ciphenothrin, permethrin, cyfluthrin, bifenthrin, tralomethrin, imiprotolin, transfluthrin, methfluthrin, profluthrin, pyrethroid compounds such as etofenprox, silicon compounds such as silafluophene, dichlorvos , Organophosphorus compounds such as fenitrothion, carbamate compounds such as propoxur, neonicotinoid compounds such as dinotefuran, imidacloprid, clothianidin, fipronil, indoxacarb, etc. Hinokitiol, 2-mercaptobenzothiazole, 2- (4-thiazolyl) benzimidazole, 5-chloro-2-methyl-4-isothiazolin-3-one Triforine, 3-4-isopropyl phenol, ortho - phenylphenol and the like.
In addition, as a deodorant component, for example, oyster family, gramineous family, camellia family (tea), ginkgo family, oleander family (such as cinnamon), mulberry family (such as fig), citrus family, quinolanoceae family (such as acerola) A plant-derived substance may be added. This deodorant component not only deodorizes the object, such as carpets and bedding, but also deodorizes food odors such as sebum and sweat that ticks prefer and prevents mites from approaching. It also has merit.

Examples of the solvent include water, lower alcohols having 2 to 3 carbon atoms such as ethanol and isopropanol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, diethylene glycol, dipropylene glycol, and hexylene glycol. Examples include glycols having 3 to 6 carbon atoms, glycol ethers thereof, ketone solvents, ester solvents, and hydrocarbon solvents such as kerosene.

Examples of the propellant used in preparing the aerosol agent include liquefied petroleum gas (LPG) and dimethyl ether, and compressed gases such as nitrogen gas, carbon dioxide gas, nitrous oxide, and compressed air. Of these, one or more of them can be employed as appropriate, but usually those mainly composed of LPG are easy to use.

Examples of the surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alkyl ethers (polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, etc.), polyoxyethylene alkylphenyl ethers, polyoxyethylene higher fatty acid. Nonionic surfactants such as esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene polyoxypropylene alkyl ether, laurylamine oxide, stearylamine oxide, amidopropyldimethyl laurate Examples thereof include higher alkyl amine oxide surfactants such as amine oxide.

Furthermore, you may mix | blend the mite allergen reducing agent containing a cationic surfactant or an anionic surfactant with the indoor mite repellent composition used by this invention. That is, while the live mites are kept away from the target area, the allergen activity is reduced for the remaining dead mites and mite feces and the like, and a clean environment free from mite allergens can be efficiently provided.
Cationic surfactants include dilong chain alkyldishort chain alkyl quaternary ammonium salts (distearyldimethylammonium salt, distearylmethylhydroxyethylammonium salt, dioleyldimethylammonium salt, etc.), monolong chain alkyltrishort chain Examples include alkyl type quaternary ammonium salts (such as lauryl trimethyl ammonium salt and stearyl dimethyl benzyl ammonium salt) and tri long chain alkyl mono short chain alkyl type quaternary ammonium salts (such as trilauryl methyl ammonium chloride and tristearyl methyl ammonium chloride). . In addition, the mixing | blending of a suitable quantity cationic surfactant also has the merit that a softness | flexibility can be provided to a process fiber body.
On the other hand, examples of anionic surfactants include lauryl benzene sulfonate, lauryl sulfate, lauryl sulfate triethanolamine, and polyoxyethylene lauryl ether sulfate. An agent may be configured.

In addition, as an aromatic component, orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, citronella oil, lime oil, yuzu oil, jasmine oil, coconut oil, green tea essential oil, limonene, α-pinene, linalool, geraniol, Examples include, but are not limited to, aromatic components such as phenylethyl alcohol, amylcinnamic aldehyde, cuminaldehyde, and benzyl acetate, green leaf alcohol called “green scent”, and flavor components containing green leaf aldehyde.

The present invention also provides an indoor mite repellent method for indoor treatment of the indoor mite repellent composition containing an indoor mite repellent efficacy enhancer. When the dosage form of the indoor tick repellent composition is a liquid, emulsion, aqueous solvent, etc., it is common to fill it into a trigger pump and use it as a spray agent. It can also be impregnated with a liquid-absorbing liquid and used as a coating agent.
For the trigger pump, the shape of the nozzle, nozzle, etc. can be selected as appropriate according to its application, purpose of use, etc. For example, if a type with a wide-angle nozzle is used, a wide range can be processed with a single operation. It is convenient. In addition, as a spray amount, about 10-50 mL / m < ² > (10-1000 mg / m < ² > as an indoor tick repellent component amount) is suitable with respect to a target surface, and the spray particle diameter at the time of the spraying is scattered spray particles. In order to reduce it, it is good to set to about 50-150 micrometers.

On the other hand, with regard to the aerosol agent, in consideration of the adhesion efficiency to the target surface, the aerosol stock solution / propellant ratio is set to 20 to 60/40 to 80 (volume ratio). 50 μm spray particles account for more than 60% of the total, and 30 to 80% of the total spray particles are designed to settle to the floor surface or adhere to the wall surface by 1 hour after the spray treatment. Is preferred.

As a form of the aerosol agent, a conventional injection type may be used, but a type that includes a constant-amount aerosol valve and performs a certain amount of space spray treatment is easy to use and highly convenient. That is, it is a type that sprays a fixed amount indoors, preferably 0.2 to 0.9 mL (0.5 to 50 mg / m ³ as an indoor tick repellent component amount) toward the air at one time, and other nozzles and nozzles The shape of the container or the like may be appropriately selected according to its use, purpose of use, and the like. For example, it can be designed as a desktop type equipped with a button to be sprayed from above and an obliquely upward nozzle, or designed for carrying a small container.

The indoor tick repellent method of the present invention is applied to tatami mats, carpets, floors, beds, futons, pillows, cushions, stuffed toys, cloth sofas, etc. in living rooms, Japanese-style rooms, entrances and the like. And the indoor mite repellent composition attached to the target surface has a remarkable indoor mite repellent effect against acarid mites, leopard mites, dust mites, claw mites, etc. due to the action of the indoor mite repellent efficacy enhancer of the present invention, and has a residual effect. It is extremely useful because of its excellent properties.

Next, based on a specific Example, the indoor tick repellent efficacy enhancer of this invention and the indoor tick repellent method using the same are demonstrated in detail.

An aerosol stock solution was prepared by dissolving 10 w / v% cyclohexyl salicylate and 2.0 w / v% isoeugenol in isopropyl myristate. The aerosol stock solution 12 mL and liquefied petroleum gas 18 mL [aerosol stock solution / propellant ratio: 40/60 (volume ratio)] were pressurized and filled into an aerosol container with an aerosol valve for quantitative spraying, and the indoor tick repellent aerosol used in the present invention. Got.
The aerosol spray particles accounted for 80% of the spray particles of 10 to 50 μm in the distribution.

In the center of a 6-tatami room, which was almost sealed, the aerosol agent was sprayed for 4 shots at 0.2 mL per shot toward the upper four corners. As for this aerosol agent, 65% of the entire spray particles settled on the floor surface by 1 hour after the spray treatment or adhered to the wall surface, and did not attract indoor dust mites for about 2 weeks. In addition, this aerosol agent was effective about 30 times when 0.8 mL (0.2 mL × 4) was used at a time.

1.0% by weight of cyclohexyl benzoate, 3.0% by weight of heptyl caprate, 0.5% by weight of cocoon extract (0.025% by weight as kakitannin), 54% by weight of 95% ethanol, and water An indoor mite repellent composition containing 41.5% by mass was prepared, and 350 mL of this aqueous solution was filled in a plastic resin trigger pump to obtain an indoor mite repellent spray used in the present invention. This agent falls under the category of non-hazardous substances under the Fire Service Act, and the average spray particle size during spraying was 95 μm.

When about 10 mL of this indoor mite repellent spray was sprayed on a carpet in a living room per 1 m ² , indoor dust mites did not come close to the carpet for about 1 month. This agent was excellent in quick-drying and did not cause stains or stickiness on the carpet.

According to Example 2, various indoor mite repellent sprays shown in Table 1 were prepared, and the mite repellent effect was evaluated.
Examples 3 to 6 and 9 to 13 are shown as reference examples.
[Tick repellent efficacy test]
A 1000 cm 2 square cotton cloth was sprayed with 1 mL of the test spray, air-dried, and then cut into a 4 cm diameter circle. This was fitted into a petri dish having a diameter of 4 cm, and 50 mg of the reference medium was placed in the center. Separately, about 10,000 test leopard mites with a medium were released in a petri dish with a diameter of 9 cm, and a petri dish with a diameter of 4 cm prepared previously was placed in the center.
Similarly, a non-sprayed area was made using a cotton cloth that was not sprayed.
After 24 hours, the number of mites that had invaded the cotton cloth was counted, and the repelling rate was calculated according to the following formula.
The test was performed on a cotton cloth immediately after the spray treatment and a cotton cloth after leaving it indoors for 20 days.

Repellent rate (%) = [number of invading ticks in untreated area-number of invading ticks in treated area] / number of invading ticks in untreated area
× 100

As a result of the test, the indoor mite repellent composition containing the salicylic acid ester compound and / or the benzoic acid ester compound as the indoor mite repellent component was added to the indoor mite repellent efficacy enhancer of the present invention, i.e., the carbon of the acid portion and the alcohol portion. By combining the aliphatic carboxylic acid ester compounds having a total number of 14 to 23, it was confirmed that an excellent repellent effect was exhibited against indoor dust mites, and the repellent effect was maintained for a long period of time. In addition, as shown to this invention 10-12, 0.5-60 times was preferable for the mixture ratio with respect to the indoor tick repellent component of an indoor tick repellent efficacy enhancer.
On the other hand, as in Comparative Examples 1 to 5, salicylic acid ester compounds or benzoic acid ester compounds or the indoor mite repellent efficacy enhancer of the present invention alone had a poor repellent effect. Moreover, even when an aliphatic carboxylic acid ester compound is used as an indoor mite repellent efficacy enhancer, Comparative Examples 6 and 7 in which the total number of carbon atoms in the acid portion and the alcohol portion is outside the range of 14 to 23 have a synergistic effect. It was not obtained. Furthermore, no synergistic effect was observed in the composition (Comparative Examples 8 and 9) in which isobornyl thiocyanoacetate and the indoor mite repellent efficacy enhancer of the present invention were combined as an indoor mite repellent component.
In this way, salicylic acid ester compounds and / or benzoic acid ester compounds are employed as indoor mite repellent components, and this is an aliphatic carboxylic acid ester compound having a total number of carbon atoms of 14 to 23. It is clear that an indoor tick repellent composition comprising a combination of efficacy enhancers exhibits a specifically synergistic indoor tick repellent efficacy and provides a useful and practical method of indoor tick repellent.

The indoor mite repellent efficacy enhancer of the present invention and the indoor mite repellent method using the same may be applicable not only to indoor dust mites but also to indoor pests such as cockroaches.

Claims (3)

Octyl caprylate, butyl caprate, heptyl caprate, isopropyl laurate, propyl laurate, butyl laurate, isopropyl myristate, propyl myristate, butyl myristate, isopropyl palmitate, heptyl palmitate, isopropyl stearate, isostearic acid One or more aliphatic carboxylic acid ester compounds selected from isopropyl, ethyl linoleate, and isopropyl linoleate , and
An indoor mite repellent efficacy enhancer characterized by being blended in an indoor mite repellent composition containing one or more selected from cyclohexyl benzoate and benzyl benzoate as an indoor mite repellent component. An indoor tick repellent method comprising treating the indoor tick repellent composition containing the indoor tick repellent efficacy enhancer according to claim 1 indoors. The indoor mite repellent method according to claim 2 , wherein the indoor mite repellent composition is subjected to a certain amount of space spray treatment using an aerosol agent provided with an aerosol valve for quantitative spraying.