TWI836334B - Acarines repellent composition and acarines repellent product - Google Patents

Abstract

The present invention provides a tick repellent composition which has excellent tick repellent effect on indoor dust mites after a long period of time and is also safe for humans and animals. A tick repellent composition containing (a) 1,8-cineole and/or 1,4-cineole and (b) a fragrance component, wherein the fragrance component comprises one or more fragrance compounds having a logP value of 2.0 to 5.5. The blending ratio (a/b) of the fragrance compounds contained in the (a) component and the (b) component is set to 5 to 100 on a mass basis. (b) The fragrance compound contained in the component is at least one selected from the group consisting of ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, δ-dodecalactone, β-ionone, benzyl benzoate, linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene and amyl salicylate.

Description

Tick and mite repellent compositions and tick and mite repellent products

The present invention relates to a tick-repellent composition and a tick-repellent product for repelling indoor dust mites.

In recent years, due to changes in the home environment, the number of cases of indoor dust mites such as powder mites, house dust mites, fine mites, and carnivorous mites breeding in large numbers indoors has increased dramatically. Indoor dust mites not only cause discomfort, but also cause allergic asthma or rashes. In addition, the carcasses of dust mites that are known to cause allergic asthma can also cause allergies. Therefore, although the industry has developed indoor miticides for treating bedding such as pillows, quilts, or pillows, indoor miticides that often come into direct contact with the skin require higher safety.

With the above situation as the background, some people are also seeking technologies that do not kill indoor dust mites, but prevent ticks from approaching people or patients. So far, several proposals have been put forward. For example, in Patent Document 1, plant essential oils such as vetiver oil, patchouli oil, and clove oil are disclosed as active ingredients of indoor miticides. In addition, Patent Document 2 discloses citronellal, linalool, citral, etc. Although these known technologies claim to be natural sources and take safety into consideration, the insect repellent effect on indoor dust mites may not satisfy consumers.

In addition, as a pest repellent ingredient, eucalyptol has attracted much attention. Patent document 3 discloses a house dust mite repellent containing 1,8-cineole as an active ingredient. However, 1,8-cineole or 1,4-cineole is not easy to make the tick mite repellent effect last for a long time of more than 2 to 3 months due to its high volatility. [Prior technical document] [Patent document]

[Patent Document 1] Japanese Patent Publication No. 6-16515 [Patent Document 2] Japanese Patent Publication No. 2001-294505 [Patent Document 3] Japanese Patent Publication No. 2001-31508

[The problem that the invention wants to solve]

The present invention was completed in view of the above problems, and aims to provide a tick-repellent composition and a tick-repellent mite that are still excellent in repelling indoor dust mites even after a long period of time, and are also excellent in safety for humans and animals. products for the purpose. [Means to solve the problem]

The characteristic structure of the tick and mite repellent composition of the present invention to solve the above problems is: It is a tick and mite repellent composition containing (a) 1,8-eucalyptol and/or 1,4-eucalyptol and (b) fragrance components, wherein, The aforementioned perfume ingredients include one or more perfume compounds with a logP value of 2.0 to 5.5.

The formula of the tick and mite repellent composition according to the present invention also contains (b) fragrance ingredients in addition to (a) 1,8-cineole alcohol and/or 1,4-cineole alcohol. Here, since the fragrance component contains one or more fragrance compounds with a logP value of 2.0 to 5.5, the fragrance compound with a logP value of 2.0 to 5.5 can be used to make the fragrance compound more volatile. (a) 1,8-cineoleol and/or 1,4-cineoleol produce excellent tick-repellent effects on house dust mites that last for a long time. In addition, since the component (a) and the component (b) are excellent in safety for humans and animals, it is possible to achieve high safety as a tick and mite repellent composition.

Among the tick and mite repellent compositions of the present invention, the preferred ones are: The blending ratio (a/b) of the fragrance compound contained in the component (a) and the component (b) is set to 5 to 100 on a mass basis.

According to the tick repellent composition of this composition, since the mixing ratio (a/b) of the fragrance compound contained in the component (a) and the component (b) is set within an appropriate range, it can have both excellent tick repellent effect on indoor dust mites and high safety for humans and animals.

Among the tick and mite repellent compositions of the present invention, the preferred ones are: The fragrance compound contained in the component (b) is selected from the group consisting of ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, and δ-laurolactone. , at least one of the group consisting of β-ionone, benzyl benzoate, linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene and amyl salicylate.

According to the tick and mite repellent composition of the present composition, since the fragrance compound contained in component (b) is an appropriately selected compound, the excellent tick and mite repellent effect produced by component (a) can be stably sustained for a long time.

The tick-repellent product of the present invention for solving the above-mentioned problems is characterized in that it comprises a solid carrier, which contains any of the above-mentioned tick-repellent compositions; and a breathable packaging material, which contains or packages the above-mentioned solid carrier.

The tick and mite repellent product according to the present invention is manufactured by storing or packaging the solid carrier containing the tick and mite repellent composition of the present invention in a breathable packaging material, so the cost is relatively low, and the tick and mite repellent product can achieve excellent tick and mite repellent effect on indoor dust mites and high safety for humans and animals.

Among the tick and mite repellent products of the present invention, the preferred ones are: The aforementioned solid carrier system is a granular material with an average particle diameter of 1 to 8 mm.

According to the tick and mite repellent product of the present composition, since the average particle size of the solid carrier is adjusted to an appropriate size, the tick and mite repellent composition can be stably volatilized from the solid carrier for a long time. Furthermore, a tick and mite repellent product that is easy to use and highly practical can be made.

Among the tick and mite repellent products of the present invention, the preferred ones are: The aforementioned solid carrier contains 20 to 400 mg of the aforementioned component (a) per 1 g.

The tick-repellent product of this composition can maintain high safety because the solid carrier contains an appropriate amount of component (a), and at the same time can exert an excellent tick-repellent effect on indoor dust mites.

[Form of implementing the invention]

The tick mite repellent composition and tick mite repellent product of the present invention are described below. However, the present invention is not intended to be limited to the configuration or embodiments described below.

＜Tick and mite repellent composition＞ The tick and mite repellent composition of the present invention contains 1,8-cineole alcohol and/or 1,4-cineole alcohol (which is the component (a)) and a fragrance component (which is the component (b)). Here, the component (b) contains at least one fragrance compound having a logP value of 2.0 to 5.5, as described below.

[(a) Component] 1,8-cineole and/or 1,4-cineole used as component (a) function as tick repellent components. 1,8-cineole is a substance rich in eucalyptus essential oil; 1,4-cineole is a substance rich in mountain pepper essential oil, both of which have a refreshing aroma. 1,8-cineole or 1,4-cineole is generally known as a cough suppressant or antiviral agent, and its safety to the human body is low toxicity, non-irritant, and non-sensitizing. Furthermore, as described in the previous technical project, 1,8-cineole or 1,4-cineole is more volatile, so when used as a tick repellent component, it is not easy to make the tick repellent effect last for a long time of more than 2 to 3 months.

Moreover, as a result of the inventors' efforts to adjust the volatility of a tick and mite repellent composition containing 1,8-cineoleol and/or 1,4-cineoleol as component (a), they found that by Blending the fragrance compound with a logP value of 2.0 to 5.5 contained in component (b) described below can effectively adjust the volatility of 1,8-cineole and/or 1,4-cineole. House dust mites can still exert an excellent repellent effect on ticks and mites. In addition, the tick and mite repellent composition of the present invention is extremely practical and useful because it is relatively safe for humans and animals.

The tick-repellent composition of the present invention is prepared by adding various components to component (a) and component (b) described later, and can be applied to tick-repellent preparations of various forms. The mixing amount of component (a) relative to the total amount of the tick-repellent preparation varies with the form of the tick-repellent preparation, and is preferably set to about 0.02~1.0g per tick-repellent preparation; if it is a pillow or a bolster, it is more convenient to use one. If it is a large bedding such as a quilt or a mattress, just increase the number of applications as needed. In the present invention, in component (a), 1,8-cineole or 1,4-cineole can be used as a single substance, and eucalyptus essential oil or mountain pepper essential oil rich in these substances can also be used as an active ingredient. For example, eucalyptus essential oil containing 70% by mass or more of 1,8-cineole is widely available as a commercial product. A mixture of 1,8-cineole and 1,4-cineole may also be used as component (a), but 1,8-cineole is preferably used from the viewpoint of tick and mite repellent effect.

The blending amount of component (a) in the tick repellent composition is preferably 10 to 90% by mass, more preferably 20 to 85% by mass.

[(b)Component] The fragrance component used as component (b) functions as a volatilization adjusting component. Here, component (b) contains one or more fragrance compounds with a logP value of 2.0 to 5.5. That is, the fragrance component includes not only one kind of fragrance compound but also two or more kinds of fragrance compounds. When the fragrance ingredient includes a fragrance compound, the logP value of the fragrance compound is 2.0~5.5. When the fragrance ingredient contains two or more fragrance compounds, the logP value of each fragrance compound is preferably 2.0~5.5, but as long as the logP value of at least one fragrance compound is 2.0~5.5. By blending component (b) containing a fragrance compound with a logP value of 2.0 to 5.5 into the tick and mite repellent composition, the volatility of component (a) can be effectively adjusted, and it can still be effective against indoor dust mites after a long period of time. Excellent repellent effect on ticks and mites. (b) The preferred range of logP value of the fragrance compounds contained in the ingredient is 3.0~5.0. The logP value here refers to a coefficient indicating the affinity of an organic compound for water and 1-octanol. The 1-octanol/water partition coefficient P is the distribution equilibrium when a trace amount of a compound is dissolved as a solute in the two liquid phases of 1-octanol and water, and the ratio of the equilibrium concentrations of the compounds in each solvent, It is generally expressed as the logarithm of logP relative to the base 10. In addition, the logP value described in this manual is not an actual measured value, but a calculated value calculated using a dedicated application program (Advanced Chemistry Development (ACD/Labs) Software V11.02).

The fragrance compound with a logP value of 2.0 to 5.5 contained in the component (b) is not particularly limited, and a monocyclic or chain fragrance compound can be used. The fragrance compound with a logP value of 2.0 to 5.5 can be exemplified by the following. The number in [] after the fragrance compound indicates the logP value.

Examples of the aromatic compounds include eugenol [2.4], α-terpineol [2.7], linalool [2.8], geraniol [2.9], 3-methyl-5-phenyl-1-pentanol [3.2], citronellol [3.2], phenylhexanol [3.4], tetrahydrolinalool [3.5], methyl cinnamate [2.5], γ-decanoic acid [2.5], methyl dihydrojasmonate [2.6], ethyl benzoate [2.6], cinnamyl acetate [2.6], hexyl acetate [2.8], ethyl cinnamate [3.0], γ-undecalactone [3.0], δ-undecalactone [3.0], tricyclodecenyl acetate [3.1], allyl hexanoate [3.1], benzyl phenyl acetate [3.5], γ-dodecalactone [3.5], δ-decanoic acid Ester fragrance compounds such as dilactone [3.5], benzyl cinnamate [3.8], benzyl benzoate [3.8], linalyl acetate [3.9], geranyl acetate [3.9], 2-phenylethyl phenylacetate [3.9], tricyclodecenyl propionate [4.0], benzyl salicylate [4.2], cyclohexyl salicylate [4.5], amyl salicylate [4.6], hexyl salicylate [5.1], pentalide [5.2], ketone fragrances such as β-damascus ketone [3.3], α-damascus ketone [3.4], β-ionone [3.6], α-ionone [3.7], aldehyde fragrance compounds such as amyl cinnamaldehyde [4.4], hexyl cinnamaldehyde [4.9], hydrocarbon fragrance compounds such as limonene [4.6], etc. Among them, preferred are 3-methyl-5-phenyl-1-pentanol [3.2], citronellol [3.2], phenylhexanol [3.4], tetrahydrolinalool [3.5], ethyl cinnamate [3.0], γ-undecalactone [3.0], δ-undecalactone [3.0], tricyclic acetate selected from fragrance compounds having a logP value of 3.0 or more and 5.0 or less. Decenyl ester [3.1], allyl hexanoate [3.1], benzyl phenyl acetate [3.5], γ-dodecalactone [3.5], δ-dodecalactone [3.5], benzyl cinnamate [3.8], benzyl benzoate [3.8], linalyl acetate [3.9], geranyl acetate [3.9], 2-phenylethyl phenyl acetate [3.9], tricyclodecenyl propionate [4.0], benzyl salicylate [4 .2], cyclohexyl salicylate [4.5], amyl salicylate [4.6], β-damascene [3.3], α-damascene [3.4], β-ionone [3.6], α-ionone [3.7], amyl cinnamaldehyde [4.4], hexyl cinnamaldehyde [4.9] and limonene [4.6], preferably ethyl cinnamate [3.0], allyl hexanoate [3.1], 3-methyl-5-phenyl-1-pentanol [3.2], citronellol [3.2], δ-dodecalactone [3.5], β-ionone [3.6], benzyl benzoate [3.8], linalyl acetate [3.9], geranyl acetate [3.9], tricyclodecenyl propionate [4.0], benzyl salicylate [4.2], limonene [4.6] and amyl salicylate [4.6]. These fragrance compounds can be used alone or in combination of two or more.

In addition, the logP value of 1,8-cineole and/or 1,4-cineole used as component (a) is 1,8-cineole [2.8] and 1,4-cineole [2.4]. ]. Regarding the logP value of component (a) and the logP value of the fragrance compound contained in component (b) above, since the values show partially overlapping or close values, component (a) and component (b) complement each other at the molecular level. Furthermore, it is speculated that the component (b) containing the above-mentioned fragrance compound can effectively adjust the volatility of the component (a) in this way, and over a long period of time, it can control indoor dust mites such as mealybugs, house dust mites, fine mites, and carnivorous mites. The effect of the present invention is also excellent in repelling ticks and mites.

The blending amount of the fragrance compound contained in the component (b) of the tick repellent composition is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass.

The blending ratio (a/b) of the fragrance compound contained in component (a) and component (b) is preferably set to 5 to 100, more preferably 5 to 80 on a mass basis. When the blending ratio (a/b) is within the above range, the volatility of (a) 1,8-cineoleol and/or 1,4-cineoleol can be effectively adjusted, ensuring high safety, and through It can still exert excellent tick-repelling effect on indoor dust mites after a long period of time. Therefore, it can have both excellent tick-repelling effect on indoor dust mites and high safety for humans and animals.

[Other ingredients] In addition to the above-mentioned components (a) and (b), the tick-repellent composition of the present invention may also be appropriately mixed with various solvents or surfactants (solubilizers) such as water, ethanol, and isopropanol alcohol solvents, glycol solvents such as 1,3-butylene glycol, propylene glycol, and dipropylene glycol, glycol ether solvents such as diethylene glycol monobutyl ether and propylene glycol monomethyl ether, and aliphatic hydrocarbon solvents such as normal alkanes and isoalkanes. In addition, the tick-repellent composition of the present invention may be prepared without adding other ingredients such as solvents, except for the above-mentioned components (a) and (b).

Examples of the surfactant include non-ionic surfactants such as polyoxyethylene hardened castor oil, polyoxyethylene higher alkyl ethers (polyoxyethylene lauryl ether, polyoxyethylene oleyl ether), polyoxyethylene higher fatty acid esters, polyoxyethylene polyoxypropylene alkyl ethers, and higher alkylamine oxide-based surfactants such as laurylamine oxide, stearylamine oxide, and laurylamidopropyl dimethylamine oxide. The above surfactants may be used alone or as a mixture of two or more thereof.

In addition, the tick and mite repellent composition of the present invention may be appropriately mixed with antibacterial ingredients, anti-mold ingredients, deodorizing ingredients, aromatic ingredients, insecticide ingredients, repellent ingredients, stabilizers, pH adjusters, colorants, gelling agents, etc. Furthermore, leaf alcohol (cis-3-hexen-1-ol) or leaf aldehyde, etc., which are so-called "green leaf volatiles", may also be added; this can impart a relaxing effect and promote good sleep.

Examples of antibacterial ingredients include isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, 4-chloro-3,5-dimethylphenol, o-phenylphenol, o-cresol, m-cresol, p-cresol and other phenolic antibacterial ingredients, benzammonium chloride, benzammonium methyl sulfate, benzammonium organic Benzyl ammonium salts such as benzyl ammonium chloride, benzyl ammonium methyl sulfate, benzyl ammonium organic acid salts such as benzyl ammonium salts, cetyl pyridinium chloride, cetyl pyridinium methyl sulfate, cetyl pyridinium organic acid salts such as cetyl pyridinium salts, didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium methyl sulfate, didecyl dimethyl ammonium salts such as didecyl dimethyl ammonium salts, dilauryl dimethyl ammonium chloride, dilauryl dimethyl ammonium methyl Distearyl dimethyl ammonium salts such as dilauryl dimethyl ammonium sulfate, distearyl dimethyl ammonium chloride, distearyl dimethyl ammonium methyl sulfate, and 1,4-bis[3,3´-(1-decylpyridinium)methoxy]butane dibromide, 1,4-bis[3,3´-(1-decylpyridinium)methoxy]butane dichloride, 1,4-bis[3,3´-(1-decylpyridinium) Cationic surfactants such as 1,4-bis[3,3´-(1-decylpyridinium)methoxy]butane dimethyl sulfate, biguanide antibacterial ingredients, azole antibacterial ingredients such as tebuconazole and enilconazole, antibacterial ingredients from fruit seeds such as grapefruit seed extract, persimmon seed extract, grape seed extract, glyceryl monolaurate, glyceryl monocaprate, glycerin Glycerol monofatty acid ester-based antibacterial ingredients such as monocaprylate, chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride or chlorhexidine-based antibacterial ingredients such as chlorhexidine, octadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, dodecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, dodecyldiisopropyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldimethyl(3- triethoxysilylpropyl)ammonium chloride, tetradecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, Silicon-based antibacterial ingredients such as hexadecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, hexadecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, hexadecyldi-n-propyl (3-triethoxysilylpropyl) ammonium chloride, octadecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, octadecyldi-n-propyl (3-triethoxysilylpropyl) ammonium chloride, benzoic acid, salicylic acid , sorbic acid, ethylenediaminetetraacetic acid (EDTA), glycine, alkyl diethylaminoglycine, polylysine and other carboxylic acid antibacterial components or their salts, dehydroacetic acid, chloramine, 3-iodo-2-propyl-N-butylcarbamate (IPBC), phenoxyethanol, silver zeolite and other silver antibacterial components, pyrithione zinc, thiamine lauryl sulfate, fish albumin, hydroxyalkyl chitosan or its salts, etc. The above antibacterial components can be used alone or in a mixture of two or more.

Examples of antifungal ingredients include isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methylparaben, ethylparaben, propylparaben, Butyl parahydroxybenzoate, 4-chloro-3,5-dimethylphenol, o-phenylphenol, о-cresol, m-cresol and p-cresol and other phenolic antifungal ingredients, benzene chloride Benzalkonium salts such as ammonium, benzalkonium methyl sulfate, benzalkonium organic acid salts, benzalkonium chloride, benzethylammonium methyl sulfate, benzalkonium organic acid salts and other benzalkonium salts, spermaceti Cetylpyridinium chloride, cetylpyridinium methyl sulfate, cetylpyridinium organic acid salt, didecyldimethylammonium chloride, didecyldimethylammonium methyl Didecyl dimethyl ammonium salts such as methyl sulfate, dilauryl dimethyl ammonium chloride, dilauryl dimethyl ammonium methyl sulfate and other dilauryl dimethyl ammonium salts, distearyl dimethyl distearyl dimethyl ammonium chloride, distearyl dimethyl ammonium methyl sulfate and other distearyl dimethyl ammonium salts and 1,4-bis[3,3´-(1-decylpyridinium)methoxy ]Butane dibromide, 1,4-bis[3,3´-(1-decylpyridinium)methoxy]butane dichloride, 1,4-bis[3,3´-(1- Cationic surfactants such as decylpyridinium)methoxy]butanedimethylsulfate and other 1,4-bis[3,3´-(1-decylpyridinium)methoxy]butane salt are anti- Mildew ingredients, biguanide antifungal ingredients, tebuconazole, enconazole and other azole antifungal ingredients, grapefruit seed extract, persimmon seed extract, grape seed extract and other fruit seed extract antifungal ingredients, glycerol mono Glyceryl monofatty acid esters such as lauric acid ester, glyceryl monocaprate, and glyceryl monocaprylate are antifungal ingredients, chlorhexidine salts such as chlorhexidine gluconate, chlorhexidine hydrochloride, or chlorhexidine Hexadecyl antifungal ingredient, octadecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyldimethyl (3-triethoxysilylpropyl) ammonium chloride , dodecyldiisopropyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldimethyl Ethyl(3-triethoxysilylpropyl)ammonium chloride, Tetradecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, Pendecyldimethyl(3- Triethoxysilylpropyl)ammonium chloride, Pendecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, Pendecyldi-n-propyl(3-triethoxysilane Hexadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, hexadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride Ammonium, hexadecyl di-n-propyl (3-triethoxysilylpropyl) ammonium chloride, octadecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, octadecyl Di-n-propyl (3-triethoxysilylpropyl) ammonium chloride and other silicon-based antifungal ingredients, benzoic acid, salicylic acid, sorbic acid, ethylenediaminetetraacetic acid (EDTA), glycine, alkanes Carboxylic acid antifungal ingredients such as diethyl aminoglycine and polylysine or their salts, dehydroacetic acid, chloramine, 3-iodo-2-propyl-N-butylcarbamic acid ester (IPBC), phenoxyethanol, silver zeolite and other silver-based antifungal ingredients, zinc pyrithione, thiamine lauryl sulfate, fish white protein, hydroxyalkyl chitosan or its salt, antifungal spices, etc. The above-mentioned antifungal ingredients can be used alone or in a mixture of two or more kinds.

Deodorizing ingredients include, for example, plant-derived deodorizing ingredients. Plant-derived deodorizing ingredients include plant extracts extracted from plants of the families Gramineae, Theaceae, Ginkgoaceae, Oleaceae, Moraceae, Rutaceae, Malpighiaceae, and Ebenaceae. The plant extracts may be used alone or as a mixture of two or more; representative examples include green tea extracts and persimmon extracts.

Examples of the gelling agent include carrageenan, xanthan gum, gellan gum, gelatin, aluminum octoate, 12-hydroxystearic acid, and the like. The above-mentioned gelling agents can be used alone or in a mixture of two or more kinds.

＜Tick and mite repellent products＞ The tick and mite repellent product of the present invention contains the above-mentioned tick and mite repellent composition of the present invention, and can be prepared into various forms such as solid, liquid, gel, etc. according to the use occasion or the needs of consumers. Among them, a product form in which the tick and mite repellent composition is impregnated or retained in a solid carrier and then stored or packaged in a breathable material is preferred. The tick-repellent and mite-repellent products are only placed under or near pillows or pillows, quilts or mattresses, etc., so that the tick-repellent and mite-repellent ingredients can be effectively volatilized from the solid carrier, so the cost is low and the ability to control ticks and mites can be achieved. A tick-repellent product that has excellent tick-repellent effects on indoor dust mites and is highly safe for humans and animals.

Examples of solid carriers include pulps such as cellulose pulp, fibrous carriers such as cotton linters and rayon, beads or foams made of cellulose (regenerated cellulose), and inorganic porous bodies such as silicates, silica, and zeolites. Sublimation carriers such as trioxane and adamantane. Among these, pulps such as cellulose pulp, fibrous carriers such as cotton linters and rayon, and beads made of cellulose (regenerated cellulose) are preferred, and cellulose pulp is more preferred.

When the solid carrier is made into beads (granular), the average particle size is usually 1-8 mm, preferably 3-8 mm, and more preferably 4-7 mm. The apparent specific gravity of the solid carrier is usually about 0.10-0.35, preferably 0.15-0.30. For example, as long as the above-mentioned (a) 1,8-cineole and/or 1,4-cineole is contained in 1g of cellulose pulp, about 20-400 mg, preferably 30-300 mg, and then it is placed in a breathable packaging material, a useful and highly practical tick and mite repellent product of the present invention can be obtained.

Examples of breathable packaging materials include non-woven bags, cotton bags, mesh bags, perforated plastic containers, and the like. Among these, nonwoven bags are preferred in terms of ease of use. Examples of materials for non-woven bags include polyester (PET), polyethylene (PE), polypropylene (PP), polyamide, polylactic acid, and rayon. Non-woven bags can be made of a single fiber, or they can be a laminate or blend of polyester or polypropylene/rayon made of paper laminated. Among them, based on the fact that the volatilization amount can be adjusted twice by partially adsorbing the aforementioned (a) 1,8-eucalyptol and/or 1,4-eucalyptol, polyester, polyethylene and polyethylene are preferred. Acrylic. The shape or composition of the non-woven bag can also be appropriately determined. For example, both sides can be made of non-woven fabrics of the above-mentioned materials, or one side can be made of non-woven fabrics of the above-mentioned materials, and the other side can be made of plastic film with many small holes, and these can be laminated together. The one who becomes.

The application location of the thus obtained tick and mite repellent product of the present invention is not particularly limited. It can be placed under or near carpets, tatami mats, pillows, throw pillows, quilts, mattresses, etc.; among them, it is suitable for use as pillows, throw pillows, Used for bedding such as quilts and mattresses. As long as it is placed under or near pillows or pillows, or quilts or mattresses, the tick-repellent ingredients will evaporate from the solid carrier through the breathable material. It is not only effective against mealy mites, house dust mites, fine mites, House dust mites such as carnivorous mites, as well as various pests such as weevils, skin beetles, booklice, beetles, cockroaches, ants, mosquitoes, gnats, chironomids, flies, gnats, clothes moths, etc. It can exert a practical repellent effect for 1 to 6 months. The tick and mite repellent product of the present invention can effectively exert an insect repellent effect on indoor dust mites such as mealybugs, house dust mites, fine mites, and carnivorous mites. [Example]

The present invention will be specifically described below based on examples.

[Example 1] 400 mg of 1,8-cineol as component (a) and 8 mg of 3-methyl-5-phenyl-1-pentanol as component (b) were directly mixed to prepare a tick-repellent composition. The entire amount of this tick-repellent composition was impregnated into about 8 g of cellulose pulp particles having an average particle size of 5.5 mm and an apparent specific gravity of 0.21. Then, the cellulose pulp particles impregnated with the tick-repellent composition were placed in a non-woven bag (9×12 cm) made of a breathable polyethylene/polypropylene mixed non-woven fabric on both sides to obtain the tick-repellent product of Example 1.

[Examples 2 to 11, Comparative Examples 1 to 2, Reference Examples 1 to 3] According to the formula shown in Table 1, prepare a tick and mite repellent composition including component (a) and component (b) according to Example 1, and use the same procedure as Example 1 to obtain Examples 2 to 11 and Comparative Examples 1 to 1 2 and various tick and mite repellent products in Reference Examples 1 to 3.

[Tick and mite repellent efficacy test] Wrap the tick and mite repellent products of Examples 1 to 11, Comparative Examples 1 to 2 and Reference Examples 1 to 3 with a wool blanket, place a 4kg heavy stone on it and let it stand at room temperature for 2 months, and then recover it. Various tick and mite repellent products.

Next, a culture medium containing about 100,000 European house dust mites was evenly spread in the center of a 50 cm square cotton cloth. Each of the above tick-repellent products after being left for 2 months was placed on a pillow and covered with a pillowcase. After 1 g of the culture medium was spread on the surface, the pillow was placed in the center of the cotton cloth as the treatment area. In addition, a pillow without a tick-repellent product was used for the same operation, and it was used as the untreated area. Then, the number of ticks and mites that invaded the pillowcase after 24 hours was counted, and the tick-repellent efficacy (repellent rate) was calculated according to the following formula. Tick and mite repellent efficacy (%) = (N ₀ -N ₁ )/N ₀ × 100 N ₀ : Number of invading ticks and mites in the untreated area N ₁ : Number of invading ticks and mites in the treated area

The results of the tick and mite repellent efficacy test are shown in Table 2.

It can be seen that the tick and mite repellent products of Examples 1 to 11 all showed an excellent tick and mite repellent effect of more than 80% after 2 months. It is determined that this is because component (b), which contains fragrance compounds with logP values of 2.0 to 5.5, effectively adjusts the volatilization of (a) 1,8-cineole and/or 1,4-cineole. In Examples 1 to Among the 11 tick and mite repellent products, excellent tick and mite repellent effects can be achieved even after a long period of time. Among them, the tick and mite repellent products of Examples 1, 3 to 7, 10 and 11 containing (a) 1,8-eucalyptol and component (b) of a fragrance compound with a logP value of 3.0 to 5.0, within 2 months Both showed more than 85% effect in repelling ticks and mites, and it was found to be even better.

On the other hand, the tick repellent product of Reference Example 1 contains hexadecanolide with a logP value higher than 5.5 (logP value: 5.7) as component (b), or butyl acetate (logP value: 5.7) with a logP value lower than 2.0. Compared with the tick and mite repellent products of Examples 1 to 11, the tick and mite repellent product of Reference Example 2 (logP value: 1.8) has a worse tick and mite repellent effect after a long period of time. For fragrance compounds whose logP values deviated from 2.0 to 5.5, it was determined that the volatilization adjustment of 1,8-cineole was slightly poor because of this. From the comparison between Examples 1 to 11 and Reference Examples 1 to 3, it can be seen that by blending (a) 1,8-cineoleol and/or 1,4-cineoleol with a logP value of 2.0 to 5.5 Component (b) of the fragrance compound can further enhance the effect of repelling ticks and mites over a long period of time.

Furthermore, in the tick and mite repellent products of Comparative Example 1 and Comparative Example 2 in which other citronellal or vetiver oil is blended as component (a), component (b) containing a fragrance compound with a logP value of 2.0 to 5.5 is blended. , the effect of repelling ticks and mites is still not effective after a long period of time. It is judged from this that the fragrance compounds with logP values of 2.0 to 5.5 contained in (b) can effectively adjust the volatilization of the repellent ingredients. For (a) 1,8-eucalyptol and/or 1,4-eucalyptol Oleyl alcohol is unique. [Industrial availability]

The tick-repellent composition and tick-repellent product of the present invention can be suitably used for expelling indoor dust mites hidden in bedding (tick-repellent composition and tick-repellent product for bedding); however, it is not limited to Used to repel indoor dust mites, it can also be used for a wide range of insect repellent purposes.

Claims (6)

A tick and mite repellent composition, which is a tick and mite repellent composition containing (a) 1,8-eucalyptol and/or 1,4-eucalyptol and (b) a perfume component, wherein the aforementioned perfume component contains One or more fragrance compounds whose 1-octanol/water partition coefficient logP value is 2.0 to 5.5 as the affinity coefficient of organic compounds for water and 1-octanol. For example, in the tick repellent composition of claim 1, the blending ratio (a/b) of the aforementioned fragrance compound contained in the aforementioned component (a) and the aforementioned component (b) is set to 5 to 100 on a mass basis. The tick repellent composition of claim 1 or 2, wherein the aforementioned fragrance compound contained in the aforementioned component (b) is at least one selected from the group consisting of ethyl cinnamate, allyl hexanoate, 3-methyl-5-phenyl-1-pentanol, citronellol, δ-dodecalactone, β-ionone, benzyl benzoate, linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene and amyl salicylate. A tick and mite repellent product, which includes a solid carrier, which contains the tick and mite repellent composition according to any one of claims 1 to 3; and a breathable packaging material, which stores or packages the aforementioned solid carrier. Such as the tick and mite repellent product of claim 4, wherein the solid carrier system is a granular material with an average particle size of 1 to 8 mm. For example, the tick and mite repellent product of claim 4 or 5, wherein the aforementioned solid carrier contains 20 to 400 mg of the aforementioned component (a) per 1 g.