JP6656753B2 - Insect repellent and mite repellent for clothing - Google Patents

Description

The present invention relates to an insect repellent and a tick repellent for clothing.

2. Description of the Related Art Conventionally, various insect repellents have been put to practical use, mainly for use in closets, drawers, closets, and clothes storage boxes, in order to protect textiles from clothing pests such as burs, hornworms and spots. As the active ingredient, sublimable insect repellent components such as p-dichlorobenzene and naphthalene were used in the past. However, safety problems and strong pungent odors were pointed out, and normal-temperature volatile pyrethroid insecticidal components such as empentrin and profluthrin were used. Is the mainstream. The latter pyrethroid-based insecticide is odorless, has a very small insecticidal effect on clothing pests, and is highly safe and highly useful.
In recent years, the needs of consumers have diversified, and there has been a tendency to actively use the insect repellent having a somewhat more aromatic nature than odorlessness to aroma the treatment space and clothing. .

Against this background, some proposals have been made to use natural essential oils and fragrance components having insect repellent effects and aromaticity as insect repellent components.
For example, JP-A-50-24436 discloses linalool, anethole, menthol, cinamic aldehyde, thymol and eugenol, and JP-B-57-5761 discloses anethole, eugenol, anisaldehyde dimethyl acetal, p-isopropylanisole, isocabebitol, In JP-A-7-112907, 1,4-diethoxybenzene is disclosed as linalool, geraniol, borneol, nerolidol, nerol, α-terpineol, perilaldehyde, citral, camphor, α-yonone, 1,8-cineole, linalool. The use of oxide or citral diethyl acetal as an active ingredient in insect repellents is described. Japanese Patent No. 4311773 focuses on hatching inhibitors for clothing pests, and believes that suppression of the transfer from eggs to larvae can prevent food damage by clothing pests. Linarol and geranio are egg hatching inhibitors. Numerous terpene compounds have been proposed, such as benzyl, citronellal, allyl heptanoate and neryl acetate.
On the other hand, attempts have been made to add an added value to the conventional functions of the insect repellent for clothing, and to develop an insect repellent for clothing having more multifunctional effects.
For example, those obtained by imparting a fungicide component to an insect repellent for clothing, those imparted with a deodorizing effect, and the like can be mentioned. Under such a background, it was considered that if one product could impart not only an effect against clothing pests but also a repellent effect against indoor ticks as an anti-mite effect, it would be convenient in daily life.
However, simply mixing the active ingredient against clothing pests and the repellent against mites remains a problem in the balance between the production cost and the odor of the resulting formulation, and it is still not recognized that the insect repellent effect and the mite repellent effect are satisfactory. Not been.

JP-A-50-24436 JP-B-57-5761 JP-A-7-112907 Japanese Patent No. 4311773 JP 2014-136885 A

The present invention provides an insect repellent and mite repellent for clothing, which has both an effect of controlling insect pests and an effect of repelling mites. The present invention provides an insect repellent and mite repellent for clothing containing a fragrance component capable of imparting a fragrance suitable for storing clothes. The purpose is to:

In order to achieve the above object, the present invention examined various flavor components, and found that even if 3-methyl-5-phenyl-1-pentanol is a single component, the pest control effect and the mite repellent effect of the clothing pests are suppressed. I found that I had both. Furthermore, it has been found that the combined use of 3-methyl-5-phenyl-1-pentanol with a carboxylic acid allyl ester compound which does not originally have a mite repellent effect enhances the mite repellent effect, It has the following configuration.
(1) An insect repellent and tick repellent for clothing containing 3-methyl-5-phenyl-1-pentanol, which, in addition to the above-mentioned 3-methyl-5-phenyl-1-pentanol, has a tick repellent activity-enhancing component An insecticide and tick repellent for clothing, comprising one or more selected from allyl carboxylate, allyl hexanoate, allyl heptanoate and allyl octanoate .

Although 3-methyl-5-phenyl-1-pentanol which is a component of the insect repellent and the insect repellent for clothing of the present invention is known as a fragrance component having activity against clothing pests (Japanese Patent Application Laid-Open No. 2014-136686). ), It is not known to have a tick repellent activity in addition to an activity against clothing pests. Furthermore, by using a carboxylic acid allyl ester compound which does not originally have a mite repellent effect with 3-methyl-5-phenyl-1-pentanol, a new finding that the mite repellent effect is enhanced was obtained. , Its practicality is extremely high.

The clothing insect repellent and tick repellent of the present invention is characterized by containing 3-methyl-5-phenyl-1-pentanol as an active ingredient.

The present inventors screened various flavor components for insect repellent activity at the same time as insect repellent activity for clothing pests. As a result, 3-methyl-5-phenyl-1-pentanol showed repellent activity against ticks in addition to insect repellent activity against clothing insect pests. The present inventors have newly found that it can be used as a component of an insect repellent for clothing having mite repellent activity.

In addition, the insect repellent activity for clothing pests referred to in the present invention encompasses not only the insecticidal effect of clothing pests against larvae and adults, but also the comprehensive effect including the repellent effect and the effect of preventing invasion and food damage to clothing and the like. Shall be. Further, the term "tick repellent activity" means that the tick is kept away from clothing and the like, and encompasses an overall effect including an effect of preventing infestation and settlement.

The insect repellent and tick repellent for clothing of the present invention include, in addition to the above-mentioned 3-methyl-5-phenyl-1-pentanol, carboxyl as an ingredient for enhancing the mite repellent activity of the present 3-methyl-5-phenyl-1-pentanol. It is characterized by containing an acid allyl ester compound.
The present carboxylic acid allyl ester compound as a component for enhancing the mite repellent activity of the present 3-methyl-5-phenyl-1-pentanol has insect repellent activity against clothing pests, but does not show tick repellent activity by itself. In combination with the 3-methyl-5-phenyl-1-pentanol of the present invention, the mite repellent activity of 3-methyl-5-phenyl-1-pentanol is enhanced.
Specific examples of the allyl carboxylate compound include allyl cyclohexylpropionate, allyl hexanoate, allyl heptanoate and allyl octanoate, with allyl hexanoate, allyl heptanoate and allyl octanoate being particularly preferred.
Further, the insect repellent and mite repellent for clothing of the present invention may be mixed with a normal-temperature-volatile pyrethroid-based insecticidal component or another fragrance component having insect repellent activity to enhance the insect repellent effect and to provide fragrance.
Examples of the normal-temperature volatile pyrethroid insecticidal component include empentrin, transfluthrin, methfluthrin, and profluthrin.
And, as another fragrance component having insect repellent activity, terpineol, citronellol, geraniol, nerol, linalool, dihydro linalool, tetrahydro linalool, dihydro myrcenol, menthol, borneol, terpene alcohol such as isoborneol, citronellal, citral, Examples include, but are not limited to, terpene-based aldehydes such as dimethyloctanal, and terpene-based ketones such as carboxylic, dihydrocarbon, pulegone, and menthone. In addition, plant essential oils containing these components, for example, citronella oil, cinnamon oil, eucalyptus oil, lemon eucalyptus oil, hiba oil, lavender oil, orange oil, grapefruit oil, cedarwood oil, geranium oil, thyme oil, peppermint oil Etc. may be blended.

The insect repellent and tick repellent for clothing of the present invention may optionally contain an antifungal component such as 2-phenylphenol (OPP) or 4-isopropyl-3-methylphenol (IPMP) as necessary. Further, an antibacterial component, a disinfecting component, a deodorant component, a stabilizer such as BHT, a pH adjuster, a coloring agent, and the like may be appropriately blended, or, for example, green leaf alcohol or green leaf called “green scent” Aldehyde or the like can be added to give a relaxing effect when the storage is opened.

In the present invention, a stock solution of insect repellent and mite repellent for clothing can be prepared and formulated into various forms such as liquid, gel, beads, solid, sheet, etc. according to the needs of the scene of use.
In preparing a liquid clothing insect repellent and tick repellent, in addition to water, alcohol solvents such as ethanol and isopropanol, glycol solvents such as 1,3-butylene glycol, propylene glycol and dipropylene glycol, and diethylene glycol Various solvents such as glycol ether solvents such as monobutyl ether and propylene glycol monomethyl ether, aliphatic hydrocarbon solvents, and surfactants (solubilisers) are appropriately used.
Examples of the surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alkyl ether (polyoxyethylene lauryl ether, polyoxyethylene oleyl ether), polyoxyethylene higher fatty acid ester, and polyoxyethylene polyoxypropylene alkyl ether. Examples thereof include nonionic surfactants and higher alkylamine oxide surfactants such as laurylamine oxide, stearylamine oxide, and lauric amide propyldimethylamine oxide.
Further, examples of the gelling agent used for preparing the gel-like body include carrageenan, xanthan gum, gellan gum, gelatin, aluminum octylate, 12-hydroxystearic acid and the like.
In addition, the beads can be adjusted by holding liquid insect repellent and mite repellent components for clothing on gel beads made of a specific water-absorbing polymer.
As the water-absorbing polymer forming the aqueous gel beads, an acrylic acid-based water-absorbing polymer is preferably used. The acrylic acid-based water-absorbing polymer is excellent in water-absorbing properties and can absorb 100 times or more its own weight of water. An acrylic acid-based water-absorbing polymer having a particle size of about 2 mm can expand to a particle size of about 10 mm while maintaining a substantially transparent state even after absorbing the impregnating liquid. Acrylic acid-based water-absorbing polymers include acrylic acid / acrylate copolymers (such as acrylic acid / sodium acrylate copolymer and acrylic acid / potassium acrylate copolymer) and acrylamide / acrylic acid or a salt thereof. And a copolymer of

When the solid carrier is impregnated or held with the insect repellent and tick repellent components for clothing of the present invention, in addition to the liquid or gel-like and bead-like shapes, it can be manufactured by storing in a breathable case or bag. . Then, such an insect repellent may be installed in a closet, a drawer, a closet or a clothing storage box, and the active ingredient may be volatilized from the solid carrier. Examples of the solid carrier include fibrous carriers such as pulp, linter, and rayon; beads or foams made of cellulose (regenerated cellulose); inorganic porous carriers such as silicate, silica, and zeolite; and sublimable carriers such as trioxane and adamantane. Is raised. As the fibrous carrier, a mat or sheet having a thickness of about 1 to 3 mm is easy to use, while in the case of cellulose beads, a deodorizing effect can be imparted by blending charcoal with the beads.

In this case, examples of the permeable case include a plastic container having an opening, and examples of the permeable bag include a nonwoven fabric bag, a cotton bag, and a net case. In the case of the latter nonwoven fabric bag, the material of the nonwoven fabric is not particularly limited, and examples thereof include polyester (PET), polyethylene (PE), polypropylene (PP), polyamide, polylactic acid, rayon and the like. Or a laminated product such as polyester or polypropylene / rayon laminated with paper (the amount of volatilization of which can be secondarily adjusted by partially adsorbing the active ingredient) or a blended product may be used. Absent. In addition, the shape and configuration of the nonwoven fabric bag can also be appropriately determined. For example, both surfaces may be made of the above-mentioned material, and the other surface may be made of the above-mentioned material, and the other surface may be made of the same. A plastic film which may have many holes may be attached.

The amount of the insect repellent and mite repellent component for clothing based on the total amount of the insect repellent and tick repellent for clothing of the present invention varies depending on the form of the preparation, but it is about 0.01 mg to 1 g per insect repellent and mite repellent for clothing. It is appropriate to set. For example, in the case of a closet or a closet, it is easy to use one to three insect repellent and tick repellents for clothing, and in the case of a drawer or a clothing storage box, the number of applications can be appropriately set as needed. Good. If the compounding amount is less than the lower limit, the desired insect repellent effect may be insufficient. On the other hand, if the compounding amount is more than necessary, a problem such as a sticky feeling may occur, which is not practical.

The insect repellent and mite repellent for clothing thus obtained can be disposed in a close-closed space such as a closet, a drawer, a closet or a clothing storage box. In addition to clothing pests such as brown beetle, pitted beetle, spotted beetle, spots, etc., they exhibit a practical repellent effect on indoor dust mites such as mites, dust mites, dust mites, and claw mites, and have extremely high practicality. .

Next, based on specific examples, the insect repellent and tick repellent for clothing of the present invention will be described in more detail.

(Insect pest control efficacy test)
1 mL of each of the flavor components listed in Table 1 diluted 10-fold with ethanol was dispensed and impregnated on a 10 × 10 cm filter paper, and the ethanol was air-dried to obtain a test filter paper.
Place the test filter paper on the bottom of a glass bottle with a capacity of about 6 L, and place 5 cm above the 10 day larvae of 30 days old, 30-35 mg / average body weight of 10 moths and a wool test cloth (2 cm × 2 cm, 40-45 mg). The basket was fixed. Next, the glass bottle was sealed and left in a constant temperature and humidity room at 27 ° C. and a humidity of 65% for 7 days. Then, the wool test cloth was taken out, and the erosion rate (amount of damage / original weight × 100) was measured. Insect rates were determined.
The evaluation was shown based on the following criteria.
：: No food damage and 100% mortality. ：: No food damage and death rate of 50 to 99%. Δ: No harm, but a mortality of 1 to 50%. ×: Those with or without food damage, but with a mortality of 0%.

(Tick repellency test)
1 mL of each of the fragrance components shown in Table 1 diluted 100 times with ethanol was dispensed and impregnated on a 10 × 10 cm filter paper, and the ethanol was air-dried to obtain a test filter paper.
A tick breeding medium (50 mg) was placed inside a glass bottle having a capacity of about 6 L as an attraction source, and a tick medium containing Dermatophagoides pteronyssinus was sprinkled around the glass bottle and allowed to stand.
Twenty-four hours later, the number of invading mites attracted into the vial was counted.
At the same time, an untreated control without using a fragrance was provided for the test, and the penetration inhibition rate was calculated by the following equation.
Invasion inhibition rate (%) = [number of invading mites in untreated area−number of invading mites in treated area] / number of invading mites in untreated area × 100
Then, based on the obtained intrusion inhibition rates, the mite repellent effect of each flavor component was further evaluated according to the following criteria.
◎: Intrusion prevention rate 90-100%, ○: Intrusion prevention rate 70-90%, Δ: Intrusion prevention rate 50-70%, ×: Intrusion prevention rate <50%

Table 1 shows the results of the clothing pest control and mite repellency tests.

As a result of the test, 3-methyl-5-phenyl-1-pentanol showed a lethal effect on clothing pests by itself as a single component, and additionally showed a repellent effect on indoor dust mites (Example 1). ).
The repellent activity of 3-methyl-5-phenyl-1-pentanol against mites is significantly increased by adding a carboxylic acid allyl ester compound (Comparative Examples 3 to 5) having a low evaluation of repellent activity against mites alone. (Examples 2 to 4).
The mite repellent activity enhancing effect of the carboxylic acid allyl ester compound was not recognized when used in combination with other perfume components such as ethylbenzoate and geraniol (Comparative Examples 7 to 10), and cyclohexylpropionic acid having a cyclic terminal was used. When allyl was used, the effect of 3-methyl-5-phenyl-1-pentanol to enhance the mite repellent activity was not observed (Example 5).

An insect repellent and mite repellent composition for clothing was prepared, which contained 20% by mass of 3-methyl-5-phenyl-1-pentanol as an insect repellent component for clothing and 10% by mass of allyl octanoate.
Next, 5.0 g of polyoxyethylene lauryl ether, 2.0 g of polyethoxyethylene hydrogenated castor oil, and 1.8 g of lauric acid amide propylamine oxide were added to 10 g of the insect repellent and tick repellent composition for clothing as surfactants. In addition, 20 g of ethanol as a solvent, 1.5 g of green tea extract as a deodorant component, 1.9 g of BHT as a stabilizer, a trace amount of an isothiazoline-based preservative, a trace amount of a bittering agent (Vitrex), and an appropriate amount of water are blended. The impregnating liquid was prepared with the whole being 386 g.

Acrylic acid / acrylic acid having a particle size of about 2 mm as a water-absorbing polymer in a cylindrical plastic container (φ: 8 cm, height: 10 cm) having an opening with a total area of 24 cm ^{2 on} the upper surface and a capacity of 500 mL 14 g of the sodium salt copolymer was added. When the impregnating solution was poured into the mixture, the water-absorbing polymer swelled, and an aqueous gel bead-type insect repellent and tick repellent of the present invention having a particle size of about 10 mm was obtained.

When this insect repellent and mite repellent for clothing of the aqueous gel bead type was used in a closet, no harm was caused to the clothing for about one year, and a practical insect repellent effect was confirmed. No mites approached in the closet. The aqueous gel beads gradually shrunk with the passage of time, but had excellent gel stability without deterioration and syneresis, and the end point of use was clearly visible. In addition, the closet had a fragrance with the initial fragrance tone, and was able to provide comfortable freshness to the surroundings, and was extremely practical.

INDUSTRIAL APPLICABILITY The present invention can be used not only as an insect repellent and acaricide for clothing but also as a wide range of insect repellents.

Claims (1)

An insect repellent and acarid repellent for clothing containing 3-methyl-5-phenyl-1-pentanol, wherein in addition to the above-mentioned 3-methyl-5-phenyl-1-pentanol, a carboxylic acid as an acaricide-enhancing activity-enhancing component An insect repellent and tick repellent for clothing comprising one or more selected from allyl ester compounds, allyl hexanoate, allyl heptanoate and allyl octanoate .