WO2022168680A1 - Mite repellent composition and mite repellent product - Google Patents

Mite repellent composition and mite repellent product Download PDF

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Publication number
WO2022168680A1
WO2022168680A1 PCT/JP2022/002706 JP2022002706W WO2022168680A1 WO 2022168680 A1 WO2022168680 A1 WO 2022168680A1 JP 2022002706 W JP2022002706 W JP 2022002706W WO 2022168680 A1 WO2022168680 A1 WO 2022168680A1
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WO
WIPO (PCT)
Prior art keywords
component
mite
tick
repellent
repellent composition
Prior art date
Application number
PCT/JP2022/002706
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French (fr)
Japanese (ja)
Inventor
友裕 田丸
帆波 三石
南美 片山
佳浩 猪口
知幸 引土
宏文 下方
幸治 中山
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大日本除蟲菊株式会社
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Publication date
Application filed by 大日本除蟲菊株式会社 filed Critical 大日本除蟲菊株式会社
Priority to JP2022579468A priority Critical patent/JPWO2022168680A1/ja
Priority to CN202280012397.9A priority patent/CN116744793A/en
Publication of WO2022168680A1 publication Critical patent/WO2022168680A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M29/00—Scaring or repelling devices, e.g. bird-scaring apparatus
    • A01M29/30—Scaring or repelling devices, e.g. bird-scaring apparatus preventing or obstructing access or passage, e.g. by means of barriers, spikes, cords, obstacles or sprinkled water
    • A01M29/34—Scaring or repelling devices, e.g. bird-scaring apparatus preventing or obstructing access or passage, e.g. by means of barriers, spikes, cords, obstacles or sprinkled water specially adapted for insects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A01P7/02—Acaricides

Definitions

  • the present invention relates to a mite repellent composition and a mite repellent product for repelling indoor dust mites.
  • Patent Literature 1 discloses plant essential oils such as vetiver oil, patchouli oil, and clove oil as active ingredients of indoor mite control agents.
  • Patent Document 2 discloses citronellal, linalool, citral, and the like.
  • Patent Document 3 discloses a house dust mite repellent containing 1,8-cineol as an active ingredient.
  • 1,8-cineole and 1,4-cineole are relatively highly volatile, and it has been considered difficult to maintain the mite repelling effect for a long period of 2 to 3 months or longer.
  • JP-A-6-16515 Japanese Patent Application Laid-Open No. 2001-294505 JP-A-2001-31508
  • the present invention has been made in view of the above problems, and provides a mite-repellent composition that has excellent mite-repellent effect on indoor dust mites even after a long period of time and is also excellent in safety for humans and animals, and a mite-repellent composition.
  • the purpose is to provide repellent products.
  • the characteristic configuration of the tick repellent composition according to the present invention for solving the above problems is (a) 1,8-cineole and/or 1,4-cineole, (b) a perfume ingredient;
  • a tick repellent composition containing The perfume component contains one or more perfume compounds having a logP value of 2.0 to 5.5.
  • a fragrance component is included.
  • the perfume component contains one or more perfume compounds having a logP value of 2.0 to 5.5, it has relatively high volatility (a) 1,8-cineole and/or 1,4 -
  • the excellent mite-repellent effect of cineol against indoor dust mites can be sustained for a long period of time by the fragrance compound contained in component (b) having a logP value of 2.0 to 5.5.
  • the components (a) and (b) are highly safe to humans and animals, the mite-repellent composition can achieve high safety.
  • the blending ratio (a/b) between the component (a) and the fragrance compound contained in the component (b) is preferably set to 5 to 100 on a mass basis.
  • the compounding ratio (a/b) of the component (a) and the fragrance compound contained in the component (b) is set within an appropriate range, indoor dust mites It is possible to achieve both an excellent tick-repellent effect against insects and high safety for humans and animals.
  • the fragrance compounds contained in the component (b) include ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, ⁇ -dodecalactone, ⁇ -ionone, benzyl benzoate, It is preferably at least one selected from the group consisting of linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene, and amyl salicylate.
  • tick-repellent composition of this configuration since an appropriate fragrance compound is selected as the component (b), the excellent tick-repellent effect of the component (a) can be stably maintained for a long period of time. be able to.
  • the characteristic configuration of the tick repellent product according to the present invention for solving the above problems is a solid carrier containing any one of the above mite repellent compositions; a breathable packaging material for housing or packaging the solid carrier; to include
  • the solid carrier containing the mite repellent composition of the present invention is housed or packaged in an air-permeable packaging material. It is possible to realize a tick-repellent product with excellent tick-repellent effect and high safety for humans and animals.
  • the solid carrier is preferably a granule having an average particle size of 1 to 8 mm.
  • the solid carrier has an appropriate average particle size, so the mite repellent composition can be stably volatilized from the solid carrier for a long period of time.
  • it is easy to use and can be used as a highly practical mite-repellent product.
  • the solid carrier preferably contains 20 to 400 mg of component (a) per 1 g.
  • the solid carrier contains an appropriate amount of the component (a), it is possible to exhibit an excellent mite repelling effect against indoor dust mites while maintaining high safety. .
  • tick repelling composition and tick repelling product of the present invention are described below. However, the present invention is not intended to be limited to the configurations and examples described below.
  • the mite repellent composition of the present invention contains 1,8-cineole and/or 1,4-cineol (which is defined as component (a)) and a fragrance component (which is defined as component (b)).
  • the component (b) contains at least one perfume compound having a logP value of 2.0 to 5.5, as described later.
  • 1,8-cineole and/or 1,4-cineole used as component (a) act as a tick-repellent component.
  • 1,8-cineole is a substance abundantly contained in eucalyptus essential oil
  • 1,4-cineole is a substance abundantly contained in Aomoji essential oil, both of which have a refreshing scent.
  • 1,8-cineole and 1,4-cineole are generally known as antitussives and antiviral agents, and are considered to be of low toxicity, non-irritation and non-sensitization to humans.
  • 1,8-cineole and 1,4-cineol are relatively highly volatile as described in the background art section, so when used as a tick repellent component, they can be used for a long period of 2 to 3 months or more. It was considered difficult to maintain the tick repelling effect.
  • the present inventors have extensively studied the adjustment of the volatility of a mite repellent composition containing 1,8-cineol and/or 1,4-cineol as the component (a). ), the volatilization of 1,8-cineole and/or 1,4-cineole can be effectively adjusted by blending a fragrance compound with a logP value of 2.0 to 5.5 contained in the component. It was found that even after a long period of time, an excellent mite repelling effect was exhibited against indoor dust mites. In addition, the tick repellent composition of the present invention is highly safe for humans and animals, and is extremely practical and useful.
  • the tick-repellent composition of the present invention is prepared by adding various components to component (a) and component (b), which will be described later, and can be applied to various forms of tick-repellent products. .
  • the amount of component (a) to be added to the total amount of the mite repellent product varies depending on the form of the mite repellent product, but is preferably set to about 0.02 to 1.0 g per mite repellent product, and is used for pillows and cushions. In this case, it is easy to use one application. In the case of large bedclothes such as futons and mats, the number of applications may be increased as needed.
  • 1,8-cineole or 1,4-cineole may be used alone as the component (a), or eucalyptus essential oil or Aomoji essential oil containing a large amount of these may be used as active ingredients.
  • eucalyptus essential oil having a 1,8-cineol content of 70% by mass or more is widely available as a commercial product.
  • a mixture of 1,8-cineol and 1,4-cineol can be used as the component (a), but 1,8-cineole is preferred from the viewpoint of repelling ticks.
  • the content of component (a) in the tick repellent composition is preferably 10-90% by mass, more preferably 20-85% by mass.
  • the perfume component used as the component acts as a volatilization adjusting component.
  • the component (b) contains one or more fragrance compounds having a logP value of 2.0 to 5.5. That is, perfume ingredients include not only one perfume compound, but also those containing two or more perfume compounds. When the perfume ingredient contains one perfume compound, the logP value of the one perfume compound is 2.0 to 5.5. When the perfume ingredient contains two or more perfume compounds, the logP value of each perfume compound is preferably 2.0 to 5.5, and the logP value of at least one perfume compound is 2.0 to 5.5. 5 is acceptable.
  • component (b) containing a fragrance compound By blending component (b) containing a fragrance compound with a logP value of 2.0 to 5.5 in the tick repellent composition, the volatility of component (a) can be effectively adjusted, Even after the period of time has elapsed, an excellent mite repelling effect against indoor dust mites can be exhibited.
  • the preferred range of the logP value of the fragrance compound contained in component (b) is 3.0 to 5.0.
  • the logP value is a coefficient indicating the affinity of an organic compound for water and 1-octanol.
  • the 1-octanol/water partition coefficient P is the partition equilibrium when a trace amount of a compound is dissolved as a solute in a solvent of two liquid phases of 1-octanol and water, and is the ratio of the equilibrium concentrations of the compound in each solvent, It is common to express them in logarithmic logP form to base 10. Note that the logP values described in this specification are calculated values calculated by a dedicated application (Advanced Chemistry Development (ACD/Labs) Software V11.02), not actual measured values.
  • the fragrance compound contained in the component (b) and having a logP value of 2.0 to 5.5 is not particularly limited, but a monocyclic or chain fragrance compound can be used.
  • Examples of perfume compounds having a logP value of 2.0 to 5.5 include the following. Numbers in [] after perfume compounds represent logP values.
  • the logP values of 1,8-cineole and/or 1,4-cineole used as component (a) are 1,8-cineole [2.8], 1,4-cineole [2.4] and Become.
  • the logP value of these components (a) and the logP values of the fragrance compounds contained in the above component (b) since the numerical values partially overlap or show values close to each other, the components (a) and (b) are They have good compatibility at the molecular level.
  • the component (b) containing the fragrance compound effectively adjusts the volatility of the component (a), and even after a long period of time, indoor dust mites such as acarina pygmaena, house dust mites, dust mites, and cheyletid mites. It is presumed that the effect of the present invention, which is excellent in the tick repelling effect against, is brought about.
  • the amount of the fragrance compound contained in component (b) in the tick repellent composition is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass.
  • the blending ratio (a/b) between the component (a) and the fragrance compound contained in the component (b) is preferably set to 5 to 100, more preferably 5 to 80 on a mass basis. more preferred.
  • the volatility of (a) 1,8-cineole and/or 1,4-cineol can be effectively adjusted, ensuring high safety.
  • an excellent mite repelling effect is exhibited against indoor dust mites. Therefore, it is possible to achieve both an excellent mite repelling effect against indoor dust mites and high safety for humans and animals.
  • the tick repellent composition of the present invention contains water, alcoholic solvents such as ethanol and isopropanol, 1,3-butylene glycol, propylene glycol and dipropylene.
  • alcoholic solvents such as ethanol and isopropanol
  • 1,3-butylene glycol 1,3-butylene glycol
  • propylene glycol 1,3-butylene glycol
  • dipropylene Various solvents such as glycol solvents such as glycol, glycol ether solvents such as diethylene glycol monobutyl ether and propylene glycol monomethyl ether, aliphatic hydrocarbon solvents such as normal paraffin and isoparaffin, surfactants (solubilizers), etc.
  • the tick repellent composition of the present invention can also be prepared without adding other components such as solvents in addition to the above components (a) and (b).
  • surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alkyl ethers (polyoxyethylene lauryl ether, polyoxyethylene oleyl ether), polyoxyethylene higher fatty acid esters, polyoxyethylene polyoxypropylene alkyl ethers. and higher alkylamine oxide surfactants such as laurylamine oxide, stearylamine oxide, and lauramidopropyldimethylamine oxide.
  • the above surfactants may be used alone or as a mixture of two or more.
  • tick repellent composition of the present invention is appropriately blended with an antibacterial component, an antifungal component, a deodorant component, an aromatic component, an insecticidal component, a repellent component, a stabilizer, a pH adjuster, a coloring agent, a gelling agent, and the like.
  • an antibacterial component an antifungal component, a deodorant component, an aromatic component, an insecticidal component, a repellent component, a stabilizer, a pH adjuster, a coloring agent, a gelling agent, and the like.
  • green leaf alcohol cis-3-hexene-1-ol
  • green leaf aldehyde etc. called “green scent” may be added, thereby imparting a relaxing effect and promoting sound sleep. .
  • antimicrobial components include isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methylparaben, ethylparaben, propylparaben, butylparaben, 4-chloro-3,5-dimethylphenol, orthophenylphenol, and o-cresol.
  • IPMP isopropylmethylphenol
  • carvacrol carvacrol
  • thymol thymol
  • triclosan methylparaben
  • methylparaben methylparaben
  • ethylparaben propylparaben
  • butylparaben 4-chloro-3,5-dimethylphenol
  • orthophenylphenol and o-cresol.
  • benzalkonium chloride benzalkonium methosulfate
  • benzalkonium salts such as benzalkonium organic acid salts, benzethonium chloride, benzethonium methosulfate, benzethonium organic acid
  • Benzethonium salts such as salts, cetylpyridinium salts such as cetylpyridinium chloride, cetylpyridinium methosulfate, cetylpyridinium organic acid salts, didecyldimethylammonium salts such as didecyldimethylammonium chloride, didecyldimethylammonium methosulfate, dilauryldimethylammonium chloride, dilauryldimethylammonium salts such as dilauryldimethylammonium methosulfate, distearyldimethylammonium salt
  • Antifungal components include, for example, isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methylparaben, ethylparaben, propylparaben, butylparaben, 4-chloro-3,5-dimethylphenol, orthophenylphenol, o- Phenolic antifungal ingredients such as cresol, m-cresol, and p-cresol, benzalkonium salts such as benzalkonium chloride, benzalkonium methosulfate, and benzalkonium organic acid salts, benzethonium chloride, benzethonium methosulfate, benzethonium Benzethonium salts such as organic acid salts, cetylpyridinium salts such as cetylpyridinium chloride, cetylpyridinium methosulfate, cetylpyridinium organic acid salts, didecyldimethylammonium salts
  • Ester antifungal ingredients chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride, chlorhexidine antifungal ingredients such as chlorhexidine, octadecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyldimethyl (3-triethoxysilylpropyl) ) ammonium chloride, dodecyldiisopropyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldimethyl (3-triethoxysilylprop
  • deodorant components include plant-derived deodorant components.
  • the plant-derived deodorant components include plant extracts extracted from plants of the family Gramineae, Theaceae, Ginkgoaceae, Oleaceae, Moraceae, Rutaceae, Chrysanthemum family, Persimmon family, and the like.
  • the above plant extracts may be used singly or as a mixture of two or more, but representative examples include green tea extracts and persimmon extracts.
  • gelling agents examples include carrageenan, xanthan gum, gellan gum, gelatin, aluminum octylate, 12-hydroxystearic acid and the like.
  • the gelling agent may be used alone or as a mixture of two or more.
  • the tick-repellent product of the present invention contains the above-described tick-repellent composition of the present invention, and can be prepared in various forms such as solid, liquid, gel, etc., according to the scene of use and consumer needs. can be done. Among them, a product form in which a solid carrier is impregnated or held with a tick-repellent composition and housed or packaged in an air-permeable material is preferable. Such a mite repellent product effectively volatilizes the mite repellent component from the solid carrier simply by placing it under or near a pillow, cushion, futon, mat, etc., so that it is low cost and can prevent indoor dust mites. It is possible to realize a tick-repellent product that has an excellent tick-repellent effect against ticks and high safety for humans and animals.
  • solid carriers include pulp such as cellulose pulp, fibrous carriers such as linters and rayon, cellulose (regenerated cellulose) beads or foams, inorganic porous carriers such as silicates, silica and zeolite, trioxane, adamantane, and the like. and the like.
  • pulp such as cellulose pulp, fibrous carriers such as linter and rayon, and cellulose (regenerated cellulose) beads are preferred, and cellulose pulp is more preferred.
  • the average particle size is usually 1 to 8 mm, preferably 3 to 8 mm, more preferably 4 to 7 mm.
  • the apparent specific gravity of the solid carrier is usually about 0.10 to 0.35, preferably 0.15 to 0.30.
  • about 20 to 400 mg, preferably 30 to 300 mg, of (a) 1,8-cineol and/or 1,4-cineole are contained in 1 g of cellulose pulp, and this is contained in an air-permeable packaging material. , a useful and highly practical mite repellent product of the present invention can be obtained.
  • Breathable packaging materials include non-woven bags, cotton bags, net cases, perforated plastic containers, and the like.
  • the non-woven fabric bag is preferable in terms of ease of use.
  • materials for the non-woven fabric bag include polyester (PET), polyethylene (PE), polypropylene (PP), polyamide, polylactic acid, rayon, and the like.
  • the nonwoven bag may consist of a single fiber, or it may be a laminate or blend such as paper laminated polyester or polypropylene/rayon.
  • polyester, polyethylene, and polypropylene are preferable in that the vaporization amount can be secondarily adjusted by partially adsorbing (a) 1,8-cineole and/or 1,4-cineole. .
  • the shape and configuration of the non-woven fabric bag can also be determined as appropriate.
  • both sides may be made of the non-woven fabric of the above material, or one side may be made of the non-woven fabric of the above material and the other side may be made of a large number of small holes. It is also possible to use a plastic film having
  • the application place of the mite repellent product of the present invention obtained in this way is not particularly limited, but it can be used under or near carpets, tatami mats, pillows, cushions, futons, mats, etc. , pillows, cushions, futons, and mats.
  • the mite-repellent component volatilizes from the solid carrier via the breathable material, and indoor dust mites such as Acarina pygmaea, leopard dust mites, dust mites, and cheyletid mites.
  • the mite-repellent product of the present invention can effectively repel indoor dust mites, such as acarid mites, house dust mites, dust mites, and cheyletid mites.
  • Example 1 400 mg of 1,8-cineole as component (a) and 8 mg of 3-methyl-5-phenyl-1-pentanol as component (b) were mixed as they were to prepare a tick repellent composition. About 8 g of cellulose pulp particles having an average particle size of 5.5 mm and an apparent specific gravity of 0.21 were impregnated with the entire amount of this tick repellent composition. Then, the cellulose pulp granules impregnated with the mite-repellent composition were placed in a non-woven fabric bag (9 ⁇ 12 cm) both sides of which were made of a polyethylene-polypropylene mixed non-woven fabric with air permeability to obtain a mite-repellent product of Example 1. .
  • Examples 2-11, Comparative Examples 1-2, Reference Examples 1-3 A mite-repellent composition containing components (a) and (b) with the formulation shown in Table 1 was prepared according to Example 1, and the same procedure as in Example 1 was used to prepare Examples 2 to 11 and Comparative Examples. Various mite repellent products of 1 to 2 and Reference Examples 1 to 3 were obtained.
  • tick repellent efficacy test Each of the tick repellent products of Examples 1-11, Comparative Examples 1-2, and Reference Examples 1-3 was wrapped in a wool blanket, a weight of 4 kg was placed on it, and the product was allowed to stand at room temperature for 2 months. Each tick repellent product was collected.
  • Table 2 shows the results of the tick repellent efficacy test.
  • tick repellent products of Examples 1 to 11 all exhibited an excellent tick repellent effect of 80% or more even after 2 months. This is because the (b) component containing a perfume compound with a logP value of 2.0 to 5.5 effectively adjusted the volatilization of (a) 1,8-cineole and/or 1,4-cineol. It is believed that the tick repellent products of Examples 1 to 11 achieved excellent mite repellent effects even after a long period of time.
  • tick repellents of Examples 1, 3 to 7, 10 and 11 containing (a) 1,8-cineole and (b) component comprising a fragrance compound having a logP value of 3.0 to 5.0 All of the products showed 85% or more of the mite repelling effect even after 2 months, and were found to be superior.
  • the mite repellent product of Reference Example 1 containing cyclohexadecanolide (logP value: 5.7) with a logP value of more than 5.5, or acetic acid with a logP value of less than 2.0
  • the mite repellent product of Reference Example 2, which contained butyl (logP value: 1.8) had a reduced mite repellent effect after a long period of time compared to the mite repellent products of Examples 1 to 11. The reason for this is thought to be that the control of volatilization of 1,8-cineol is slightly poor in perfume compounds having a logP value outside the range of 2.0 to 5.5.
  • the mite repellent products of Comparative Examples 1 and 2 which contain other citronellal and vetiver oil as the component (a), contain the component (b) containing a fragrance compound having a logP value of 2.0 to 5.5. Even when blended, the mite-repellent effect was insufficient after a long period of time. From this, the phenomenon that the fragrance compound with a logP value of 2.0 to 5.5 contained in the component (b) effectively adjusts the volatilization of the pest repellent component is due to (a) 1,8-cineole and/or or is thought to be unique to 1,4-cineol.
  • the mite repellent composition and mite repellent product of the present invention can be suitably used for repelling indoor dust mites hidden in bedding (mite repellent composition for bedding and mite repellent product). Naturally, it can be used for repelling not only mites but also a wide range of insect pests.

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

Provided is a mite repellent composition having an excellent mite repellent effect against house dust mites even after a long time has elapsed and also having excellent safety for humans and animals.　A mite repellent composition contains: (a) 1,8-cineol and/or 1,4-cineol; and (b) a perfume component, wherein the perfume component includes one or more perfume compounds having a logP value of 2.0 to 5.5. The blending ratio (a/b) of component (a) to the perfume compound contained in component (b) is set to 5-100 on a mass basis. The perfume compound contained in component (b) is at least one selected from the group consisting of ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, δ-dodecalactone, β-ionone, benzyl benzoate, linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene, and amyl salicylate.

Description

ダニ忌避組成物、及びダニ忌避製品Mite repellent composition and mite repellent product
　本発明は、屋内塵性ダニ類を忌避するためのダニ忌避組成物、及びダニ忌避製品に関する。 The present invention relates to a mite repellent composition and a mite repellent product for repelling indoor dust mites.
　近年、居住環境の変化により、屋内にコナダニ、ヒョウヒダニ、ホコリダニ、ツメダニ等の屋内塵性ダニ類が大発生するという事案が増加している。屋内塵性ダニ類は、人に対して不快感を与えるばかりでなく、アレルギー性喘息や皮疹を惹起する等の問題を生じさせる。また、アレルギー性喘息を引き起こすヒョウヒダニ類は、虫体の死骸そのものでもアレルギーの原因になることが明らかとなってきた。そこで、枕、布団やクッション等の寝具類に処理するための屋内用殺ダニ剤が開発されてきたが、直接肌に接触することが多い屋内用殺ダニ剤には、より高い安全性が求められる。 In recent years, due to changes in the living environment, there has been an increase in the number of indoor dust mites such as red mites, house dust mites, dust mites, and cheyletid mites. House dust mites not only make people feel uncomfortable, but also cause problems such as allergic asthma and skin eruptions. In addition, it has become clear that the corpses of house dust mites themselves, which cause allergic asthma, also cause allergies. Therefore, indoor acaricides have been developed for treating bedding such as pillows, futons, and cushions, but higher safety is required for indoor acaricides that often come in direct contact with the skin. be done.
　かかる状況を背景として、屋内塵性ダニ類を殺すのではなく、人や患者にダニを近づけないようにする技術も模索され、これまでにいくつかの提案がなされている。例えば、特許文献１には、室内用ダニ防除剤の有効成分として、ベチバー油、パチョウリ油、クローブ油などの植物精油が開示されている。また、特許文献２には、シトロネラール、リナロール、シトラール等が開示されている。これらの従来技術は、天然産志向と安全性への配慮を謳っているが、屋内塵性ダニ類に対する忌避効果は必ずしも満足するものとは言えなかった。 Against this background, instead of killing indoor dust mites, techniques have been explored to keep mites away from people and patients, and several proposals have been made so far. For example, Patent Literature 1 discloses plant essential oils such as vetiver oil, patchouli oil, and clove oil as active ingredients of indoor mite control agents. In addition, Patent Document 2 discloses citronellal, linalool, citral, and the like. Although these prior arts advocate consideration for natural products and safety, they are not necessarily satisfactory in repelling effect against indoor dust mites.
　ところで、害虫忌避成分として、シネオールが注目されている。特許文献３には、１，８－シネオールを有効成分として含有するヒョウヒダニ忌避剤が開示されている。しかし、１，８－シネオールや１，４－シネオールは、比較的揮散性が高いため、２～３カ月以上の長期間にわたりダニ忌避効果を持続させることは困難とされていた。 By the way, cineole is attracting attention as a pest repellent ingredient. Patent Document 3 discloses a house dust mite repellent containing 1,8-cineol as an active ingredient. However, 1,8-cineole and 1,4-cineole are relatively highly volatile, and it has been considered difficult to maintain the mite repelling effect for a long period of 2 to 3 months or longer.
特開平６－１６５１５号公報JP-A-6-16515 特開２００１－２９４５０５号公報Japanese Patent Application Laid-Open No. 2001-294505 特開２００１－３１５０８号公報JP-A-2001-31508
　本発明は、上記問題点に鑑みてなされたものであり、長期間経過後においても屋内塵性ダニ類へのダニ忌避効果に優れ、人畜に対する安全性にも優れたダニ忌避組成物、及びダニ忌避製品を提供することを目的とする。 The present invention has been made in view of the above problems, and provides a mite-repellent composition that has excellent mite-repellent effect on indoor dust mites even after a long period of time and is also excellent in safety for humans and animals, and a mite-repellent composition. The purpose is to provide repellent products.
　上記課題を解決するための本発明にかかるダニ忌避組成物の特徴構成は、
　（ａ）１，８－シネオール及び／又は１，４－シネオールと、
　（ｂ）香料成分と、
を含有するダニ忌避組成物であって、
　前記香料成分は、ｌｏｇＰ値が２．０～５．５である香料化合物を一種又は二種以上含むことにある。 The characteristic configuration of the tick repellent composition according to the present invention for solving the above problems is
(a) 1,8-cineole and/or 1,4-cineole,
(b) a perfume ingredient;
A tick repellent composition containing
The perfume component contains one or more perfume compounds having a logP value of 2.0 to 5.5.
　本構成のダニ忌避組成物によれば、（ａ）１，８－シネオール及び／又は１，４－シネオールに加えて、（ｂ）香料成分を含有する処方としている。ここで、香料成分は、ｌｏｇＰ値が２．０～５．５である香料化合物を一種又は二種以上含むため、比較的揮散性が高い（ａ）１，８－シネオール及び／又は１，４－シネオールによる屋内塵性ダニ類に対する優れたダニ忌避効果を、（ｂ）成分に含まれるｌｏｇＰ値が２．０～５．５である香料化合物によって長期間持続させることができる。また、（ａ）成分及び（ｂ）成分は、人畜に対する安全性に優れているため、ダニ忌避組成物として高い安全性を実現することができる。 According to the mite repellent composition of this configuration, in addition to (a) 1,8-cineol and/or 1,4-cineol, (b) a fragrance component is included. Here, since the perfume component contains one or more perfume compounds having a logP value of 2.0 to 5.5, it has relatively high volatility (a) 1,8-cineole and/or 1,4 - The excellent mite-repellent effect of cineol against indoor dust mites can be sustained for a long period of time by the fragrance compound contained in component (b) having a logP value of 2.0 to 5.5. In addition, since the components (a) and (b) are highly safe to humans and animals, the mite-repellent composition can achieve high safety.
　本発明にかかるダニ忌避組成物において、
　前記（ａ）成分と前記（ｂ）成分に含まれる前記香料化合物との配合比（ａ／ｂ）は、質量ベースで５～１００に設定されていることが好ましい。 In the tick repellent composition according to the present invention,
The blending ratio (a/b) between the component (a) and the fragrance compound contained in the component (b) is preferably set to 5 to 100 on a mass basis.
　本構成のダニ忌避組成物によれば、（ａ）成分と（ｂ）成分に含まれる香料化合物との配合比（ａ／ｂ）が適切な範囲に設定されているため、屋内塵性ダニ類に対する優れたダニ忌避効果と、人畜に対する高い安全性とを両立させることができる。 According to the mite repellent composition of this configuration, since the compounding ratio (a/b) of the component (a) and the fragrance compound contained in the component (b) is set within an appropriate range, indoor dust mites It is possible to achieve both an excellent tick-repellent effect against insects and high safety for humans and animals.
　本発明にかかるダニ忌避組成物において、
　前記（ｂ）成分に含まれる前記香料化合物は、ケイ皮酸エチル、カプロン酸アリル、３－メチル－５－フェニル－１－ペンタノール、シトロネロール、δ－ドデカラクトン、β－イオノン、安息香酸ベンジル、酢酸リナリル、酢酸ゲラニル、プロピオン酸トリシクロデセニル、サリチル酸ベンジル、リモネン、及びサリチル酸アミルからなる群から選択される少なくとも一つであることが好ましい。 In the tick repellent composition according to the present invention,
The fragrance compounds contained in the component (b) include ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, δ-dodecalactone, β-ionone, benzyl benzoate, It is preferably at least one selected from the group consisting of linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene, and amyl salicylate.
　本構成のダニ忌避組成物によれば、（ｂ）成分に含まれる香料化合物として適切なものが選択されているため、（ａ）成分による優れたダニ忌避効果を、長期間安定して持続させることができる。 According to the tick-repellent composition of this configuration, since an appropriate fragrance compound is selected as the component (b), the excellent tick-repellent effect of the component (a) can be stably maintained for a long period of time. be able to.
　上記課題を解決するための本発明にかかるダニ忌避製品の特徴構成は、
　上記何れか一つのダニ忌避組成物を含有する固形担体と、
　前記固形担体を収納又は包装する通気性包材と、
を含むことにある。 The characteristic configuration of the tick repellent product according to the present invention for solving the above problems is
a solid carrier containing any one of the above mite repellent compositions;
a breathable packaging material for housing or packaging the solid carrier;
to include
　本構成のダニ忌避製品によれば、本発明のダニ忌避組成物を含有する固形担体を通気性包材に収納又は包装した製品態様としているため、低コストでありながら、屋内塵性ダニ類に対する優れたダニ忌避効果と、人畜に対する高い安全性とを備えたダニ忌避製品を実現することができる。 According to the mite repellent product of this configuration, the solid carrier containing the mite repellent composition of the present invention is housed or packaged in an air-permeable packaging material. It is possible to realize a tick-repellent product with excellent tick-repellent effect and high safety for humans and animals.
　本発明にかかるダニ忌避製品において、
　前記固形担体は、平均粒子径が１～８ｍｍである粒状体であることが好ましい。 In the tick repellent product according to the present invention,
The solid carrier is preferably a granule having an average particle size of 1 to 8 mm.
　本構成のダニ忌避製品によれば、固形担体の平均粒子径が適切なサイズにされているため、固形担体からダニ忌避組成物を長期間安定して揮散させることができる。また、使い勝手がよく、実用性の高いダニ忌避製品とすることができる。 According to the tick repellent product of this configuration, the solid carrier has an appropriate average particle size, so the mite repellent composition can be stably volatilized from the solid carrier for a long period of time. In addition, it is easy to use and can be used as a highly practical mite-repellent product.
　本発明にかかるダニ忌避製品において、
　前記固形担体は、前記（ａ）成分を１ｇあたり２０～４００ｍｇ含有することが好ましい。 In the tick repellent product according to the present invention,
The solid carrier preferably contains 20 to 400 mg of component (a) per 1 g.
　本構成のダニ忌避製品によれば、固形担体が（ａ）成分を適量含有しているため、高い安全性を維持しながら、屋内塵性ダニ類に対する優れたダニ忌避効果を発揮することができる。 According to the mite repellent product of this configuration, since the solid carrier contains an appropriate amount of the component (a), it is possible to exhibit an excellent mite repelling effect against indoor dust mites while maintaining high safety. .
　以下、本発明のダニ忌避組成物、及びダニ忌避製品について説明する。ただし、本発明は、以下に説明する構成や実施例に限定されることを意図するものではない。 The tick repelling composition and tick repelling product of the present invention are described below. However, the present invention is not intended to be limited to the configurations and examples described below.
＜ダニ忌避組成物＞
　本発明のダニ忌避組成物は、１，８－シネオール及び／又は１，４－シネオール（これを（ａ）成分とする）と、香料成分（これを（ｂ）成分とする）とを含有する。ここで、（ｂ）成分は、後述するように、ｌｏｇＰ値が２．０～５．５である香料化合物を少なくとも一種含む。 <Mite Repellent Composition>
The mite repellent composition of the present invention contains 1,8-cineole and/or 1,4-cineol (which is defined as component (a)) and a fragrance component (which is defined as component (b)). . Here, the component (b) contains at least one perfume compound having a logP value of 2.0 to 5.5, as described later.
　［（ａ）成分］
　（ａ）成分として使用される１，８－シネオール及び／又は１，４－シネオールは、ダニ忌避成分として作用する。１，８－シネオールはユーカリ精油に多く含まれる物質であり、１，４－シネオールはアオモジ精油に多く含まれる物質であり、いずれも清涼感のある香りを有している。１，８－シネオールや１，４－シネオールは、一般には、鎮咳剤や抗ウィルス剤として知られており、人体への安全性は、低毒性、非刺激性、非感作性とされている。また、１，８－シネオールや１，４－シネオールは、背景技術の項目で述べたように、比較的揮散性が高いため、ダニ忌避成分として使用する場合、２～３カ月以上の長期間にわたりダニ忌避効果を持続させることは困難とされていた。 [(a) component]
1,8-cineole and/or 1,4-cineole used as component (a) act as a tick-repellent component. 1,8-cineole is a substance abundantly contained in eucalyptus essential oil, and 1,4-cineole is a substance abundantly contained in Aomoji essential oil, both of which have a refreshing scent. 1,8-cineole and 1,4-cineole are generally known as antitussives and antiviral agents, and are considered to be of low toxicity, non-irritation and non-sensitization to humans. In addition, 1,8-cineole and 1,4-cineol are relatively highly volatile as described in the background art section, so when used as a tick repellent component, they can be used for a long period of 2 to 3 months or more. It was considered difficult to maintain the tick repelling effect.
　しかるに、本発明者らは、（ａ）成分として、１，８－シネオール及び／又は１，４－シネオールを含有するダニ忌避組成物の揮散性の調整について、鋭意検討した結果、後述の（ｂ）成分に含まれるｌｏｇＰ値が２．０～５．５である香料化合物を配合することで、１，８－シネオール及び／又は１，４－シネオールの揮散性を効果的に調整することができ、長期間経過後においても屋内塵性ダニ類に対して優れたダニ忌避効果を奏することを見出した。また、本発明のダニ忌避組成物は、人畜に対する安全性が高いため、極めて実用的かつ有用なものである。 However, the present inventors have extensively studied the adjustment of the volatility of a mite repellent composition containing 1,8-cineol and/or 1,4-cineol as the component (a). ), the volatilization of 1,8-cineole and/or 1,4-cineole can be effectively adjusted by blending a fragrance compound with a logP value of 2.0 to 5.5 contained in the component. It was found that even after a long period of time, an excellent mite repelling effect was exhibited against indoor dust mites. In addition, the tick repellent composition of the present invention is highly safe for humans and animals, and is extremely practical and useful.
　本発明のダニ忌避組成物は、（ａ）成分、及び後述する（ｂ）成分に、各種の成分を加えて調製したものであり、これを種々の形態のダニ忌避製品に適用することができる。（ａ）成分のダニ忌避製品全体量に対する配合量は、ダニ忌避製品の形態によっても異なるが、ダニ忌避製品１個当たり０．０２～１．０ｇ程度に設定することが好ましく、枕やクッションの場合、１個施用とするのが使いやすい。布団やマットのような大きい寝具の場合、必要に応じて適宜施用個数を増量すればよい。本発明では、（ａ）成分は、１，８－シネオールや１，４－シネオールを単品で用いてもよいし、これらを多く含むユーカリ精油やアオモジ精油を活性成分として使用しても構わない。例えば、１，８－シネオールの含有量が７０質量％以上のユーカリ精油は市販品として広く入手可能である。（ａ）成分として、１，８－シネオールと１，４－シネオールとの混合物を使用することも可能であるが、ダニ忌避効果の観点から、１，８－シネオールを使用することが好ましい。 The tick-repellent composition of the present invention is prepared by adding various components to component (a) and component (b), which will be described later, and can be applied to various forms of tick-repellent products. . The amount of component (a) to be added to the total amount of the mite repellent product varies depending on the form of the mite repellent product, but is preferably set to about 0.02 to 1.0 g per mite repellent product, and is used for pillows and cushions. In this case, it is easy to use one application. In the case of large bedclothes such as futons and mats, the number of applications may be increased as needed. In the present invention, 1,8-cineole or 1,4-cineole may be used alone as the component (a), or eucalyptus essential oil or Aomoji essential oil containing a large amount of these may be used as active ingredients. For example, eucalyptus essential oil having a 1,8-cineol content of 70% by mass or more is widely available as a commercial product. A mixture of 1,8-cineol and 1,4-cineol can be used as the component (a), but 1,8-cineole is preferred from the viewpoint of repelling ticks.
　ダニ忌避組成物中における（ａ）成分の配合量は、１０～９０質量％であることが好ましく、２０～８５質量％であることがより好ましい。 The content of component (a) in the tick repellent composition is preferably 10-90% by mass, more preferably 20-85% by mass.
　［（ｂ）成分］
　（ｂ）成分として使用される香料成分は、揮散調整成分として作用する。ここで、（ｂ）成分は、ｌｏｇＰ値が２．０～５．５である香料化合物を一種又は二種以上含む。すなわち、香料成分には、一種の香料化合物だけでなく、二種以上の香料化合物を含むものも含まれる。香料成分が一種の香料化合物を含む場合、当該一種の香料化合物のｌｏｇＰ値が２．０～５．５となる。香料成分が二種以上の香料化合物を含む場合、夫々の香料化合物のｌｏｇＰ値が２．０～５．５であることが好ましいが、少なくとも一種の香料化合物のｌｏｇＰ値が２．０～５．５であればよい。ダニ忌避組成物中にｌｏｇＰ値が２．０～５．５である香料化合物を含む（ｂ）成分を配合することで、（ａ）成分の揮散性を効果的に調整することができ、長期間経過後においても屋内塵性ダニ類に対して優れたダニ忌避効果を奏することができる。（ｂ）成分に含まれる香料化合物のｌｏｇＰ値の好ましい範囲は、３．０～５．０である。ここで、ｌｏｇＰ値とは、有機化合物の水と１－オクタノールに対する親和性を示す係数である。１－オクタノール／水分配係数Ｐは、１－オクタノールと水の２液相の溶媒に微量の化合物が溶質として溶け込んだときの分配平衡で、それぞれの溶媒中における化合物の平衡濃度の比であり、底１０に対するそれらの対数ｌｏｇＰの形で示すのが一般的である。なお、本明細書で説明するｌｏｇＰ値は、実測値ではなく、専用のアプリケーション（Advanced Chemistry Development (ACD/Labs) Software V11.02）により計算した計算値を用いることとする。 [(b) component]
(b) The perfume component used as the component acts as a volatilization adjusting component. Here, the component (b) contains one or more fragrance compounds having a logP value of 2.0 to 5.5. That is, perfume ingredients include not only one perfume compound, but also those containing two or more perfume compounds. When the perfume ingredient contains one perfume compound, the logP value of the one perfume compound is 2.0 to 5.5. When the perfume ingredient contains two or more perfume compounds, the logP value of each perfume compound is preferably 2.0 to 5.5, and the logP value of at least one perfume compound is 2.0 to 5.5. 5 is acceptable. By blending component (b) containing a fragrance compound with a logP value of 2.0 to 5.5 in the tick repellent composition, the volatility of component (a) can be effectively adjusted, Even after the period of time has elapsed, an excellent mite repelling effect against indoor dust mites can be exhibited. The preferred range of the logP value of the fragrance compound contained in component (b) is 3.0 to 5.0. Here, the logP value is a coefficient indicating the affinity of an organic compound for water and 1-octanol. The 1-octanol/water partition coefficient P is the partition equilibrium when a trace amount of a compound is dissolved as a solute in a solvent of two liquid phases of 1-octanol and water, and is the ratio of the equilibrium concentrations of the compound in each solvent, It is common to express them in logarithmic logP form to base 10. Note that the logP values described in this specification are calculated values calculated by a dedicated application (Advanced Chemistry Development (ACD/Labs) Software V11.02), not actual measured values.
　（ｂ）成分に含まれるｌｏｇＰ値が２．０～５．５である香料化合物は、特に限定されないが、単環式もしくは鎖式の香料化合物を使用することができる。かかるｌｏｇＰ値が２．０～５．５である香料化合物としては、以下のものが例示される。香料化合物の後の［］内の数字は、ｌｏｇＰ値を表す。 The fragrance compound contained in the component (b) and having a logP value of 2.0 to 5.5 is not particularly limited, but a monocyclic or chain fragrance compound can be used. Examples of perfume compounds having a logP value of 2.0 to 5.5 include the following. Numbers in [] after perfume compounds represent logP values.
　オイゲノール［２．４］、α－テルピネオール［２．７］、リナロール［２．８］、ゲラニオール［２．９］、３－メチル－５－フェニル－１－ペンタノール［３．２］、シトロネロール［３．２］、フェニルヘキサノール［３．４］、テトラヒドロリナロール［３．５］等のアルコール系香料化合物、ケイ皮酸メチル［２．５］、γ－デカラクトン［２．５］、ジヒドロジャスモン酸メチル［２．６］、安息香酸エチル［２．６］、酢酸シンナミル［２．６］、酢酸ヘキシル［２．８］、ケイ皮酸エチル［３．０］、γ－ウンデカラクトン［３．０］、δ－ウンデカラクトン［３．０］、酢酸トリシクロデセニル［３．１］、カプロン酸アリル［３．１］、フェニル酢酸ベンジル［３．５］、γ－ドデカラクトン［３．５］、δ－ドデカラクトン［３．５］、ケイ皮酸ベンジル［３．８］、安息香酸ベンジル［３．８］、酢酸リナリル［３．９］、酢酸ゲラニル［３．９］、フェニル酢酸２－フェニルエチル［３．９］、プロピオン酸トリシクロデセニル［４．０］、サリチル酸ベンジル［４．２］、サリチル酸シクロヘキシル［４．５］、サリチル酸アミル［４．６］、サリチル酸ヘキシル［５．１］、ペンタライド［５．２］等のエステル系香料化合物、β－ダマスコン［３．３］、α－ダマスコン［３．４］、β－イオノン［３．６］、α－イオノン［３．７］等のケトン系香料、アミルシンナミックアルデヒド［４．４］、ヘキシルシンナミックアルデヒド［４．９］等のアルデヒド系香料化合物、リモネン［４．６］等の炭化水素系香料化合物等が挙げられる。中でも、単環式もしくは鎖式の香料化合物であり、ｌｏｇＰ値が、３．０以上、５．０以下である香料化合物である、３－メチル－５－フェニル－１－ペンタノール［３．２］、シトロネロール［３．２］、フェニルヘキサノール［３．４］、テトラヒドロリナロール［３．５］、ケイ皮酸エチル［３．０］、γ－ウンデカラクトン［３．０］、δ－ウンデカラクトン［３．０］、酢酸トリシクロデセニル［３．１］、カプロン酸アリル［３．１］、フェニル酢酸ベンジル［３．５］、γ－ドデカラクトン［３．５］、δ－ドデカラクトン［３．５］、ケイ皮酸ベンジル［３．８］、安息香酸ベンジル［３．８］、酢酸リナリル［３．９］、酢酸ゲラニル［３．９］、フェニル酢酸２－フェニルエチル［３．９］、プロピオン酸トリシクロデセニル［４．０］、サリチル酸ベンジル［４．２］、サリチル酸シクロヘキシル［４．５］、サリチル酸アミル［４．６］、β－ダマスコン［３．３］、α－ダマスコン［３．４］、β－イオノン［３．６］、α－イオノン［３．７］、アミルシンナミックアルデヒド［４．４］、ヘキシルシンナミックアルデヒド［４．９］及びリモネン［４．６］からなる群より選択される１種以上であることが好ましく、ケイ皮酸エチル［３．０］、カプロン酸アリル［３．１］、３－メチル－５－フェニル－１－ペンタノール［３．２］、シトロネロール［３．２］、δ－ドデカラクトン［３．５］、β－イオノン［３．６］、安息香酸ベンジル［３．８］、酢酸リナリル［３．９］、酢酸ゲラニル［３．９］、プロピオン酸トリシクロデセニル［４．０］、サリチル酸ベンジル［４．２］、リモネン［４．６］、及びサリチル酸アミル［４．６］が好ましい。これらの香料化合物は、単独で使用してもよいし、二種以上の混合物として使用してもよい。 eugenol [2.4], α-terpineol [2.7], linalool [2.8], geraniol [2.9], 3-methyl-5-phenyl-1-pentanol [3.2], citronellol [ 3.2], phenylhexanol [3.4], tetrahydrolinalool [3.5], methyl cinnamate [2.5], γ-decalactone [2.5], methyl dihydrojasmonate [2.6], ethyl benzoate [2.6], cinnamyl acetate [2.6], hexyl acetate [2.8], ethyl cinnamate [3.0], γ-undecalactone [3.0] ], δ-undecalactone [3.0], tricyclodecenyl acetate [3.1], allyl caproate [3.1], benzyl phenylacetate [3.5], γ-dodecalactone [3. 5], δ-dodecalactone [3.5], benzyl cinnamate [3.8], benzyl benzoate [3.8], linalyl acetate [3.9], geranyl acetate [3.9], phenylacetic acid 2-phenylethyl [3.9], tricyclodecenyl propionate [4.0], benzyl salicylate [4.2], cyclohexyl salicylate [4.5], amyl salicylate [4.6], hexyl salicylate [ 5.1], ester perfume compounds such as pentalide [5.2], β-damascone [3.3], α-damascone [3.4], β-ionone [3.6], α-ionone [3 .7] and other ketone fragrances, amyl cinnamic aldehyde [4.4], hexyl cinnamic aldehyde [4.9] and other aldehyde fragrance compounds, and limonene [4.6] and other hydrocarbon fragrance compounds. mentioned. Among them, 3-methyl-5-phenyl-1-pentanol [3.2 ], citronellol [3.2], phenylhexanol [3.4], tetrahydrolinalool [3.5], ethyl cinnamate [3.0], γ-undecalactone [3.0], δ-undeca lactone [3.0], tricyclodecenyl acetate [3.1], allyl caproate [3.1], benzyl phenylacetate [3.5], γ-dodecalactone [3.5], δ-dodeca lactone [3.5], benzyl cinnamate [3.8], benzyl benzoate [3.8], linalyl acetate [3.9], geranyl acetate [3.9], 2-phenylethyl phenylacetate [3 .9], tricyclodecenyl propionate [4.0], benzyl salicylate [4.2], cyclohexyl salicylate [4.5], amyl salicylate [4.6], β-damascone [3.3], α-damascone [3.4], β-ionone [3.6], α-ionone [3.7], amyl cinnamic aldehyde [4.4], hexyl cinnamic aldehyde [4.9] and limonene [4] .6], ethyl cinnamate [3.0], allyl caproate [3.1], 3-methyl-5-phenyl-1-pentanol [3.2], citronellol [3.2], δ-dodecalactone [3.5], β-ionone [3.6], benzyl benzoate [3.8], linalyl acetate [3.9], acetic acid Geranyl [3.9], tricyclodecenyl propionate [4.0], benzyl salicylate [4.2], limonene [4.6], and amyl salicylate [4.6] are preferred. These perfume compounds may be used alone or as a mixture of two or more.
　ちなみに、（ａ）成分として使用される１，８－シネオール及び／又は１，４－シネオールのｌｏｇＰ値は、１，８－シネオール［２．８］、１，４－シネオール［２．４］となる。これら（ａ）成分のｌｏｇＰ値と上記（ｂ）成分に含まれる香料化合物のｌｏｇＰ値とにおいて、数値が一部重複もしくは近い値を示すことから、（ａ）成分と（ｂ）成分とは、分子レベルでの相性が良いものとなる。そして、このことが、上記香料化合物を含む（ｂ）成分が（ａ）成分の揮散性を効果的に調整し、長期間経過後においてもコナダニ、ヒョウヒダニ、ホコリダニ、ツメダニ等の屋内塵性ダニ類に対するダニ忌避効果に優れるという本発明の効果をもたらしていると推察される。 Incidentally, the logP values of 1,8-cineole and/or 1,4-cineole used as component (a) are 1,8-cineole [2.8], 1,4-cineole [2.4] and Become. In the logP value of these components (a) and the logP values of the fragrance compounds contained in the above component (b), since the numerical values partially overlap or show values close to each other, the components (a) and (b) are They have good compatibility at the molecular level. This means that the component (b) containing the fragrance compound effectively adjusts the volatility of the component (a), and even after a long period of time, indoor dust mites such as acarina pygmaena, house dust mites, dust mites, and cheyletid mites. It is presumed that the effect of the present invention, which is excellent in the tick repelling effect against, is brought about.
　ダニ忌避組成物中における（ｂ）成分に含まれる香料化合物の配合量は、０．０１～２０質量％であることが好ましく、０．１～１０質量％であることがより好ましい。 The amount of the fragrance compound contained in component (b) in the tick repellent composition is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass.
　（ａ）成分と（ｂ）成分に含まれる香料化合物との配合比（ａ／ｂ）は、質量ベースで５～１００に設定されていることが好ましく、５～８０に設定されていることがより好ましい。配合比（ａ／ｂ）が上記範囲内にある場合、（ａ）１，８－シネオール及び／又は１，４－シネオールの揮散性を効果的に調整することができ、高い安全性を確保しながら、長期間経過後においても屋内塵性ダニ類に対して優れたダニ忌避効果を奏するものとなる。従って、屋内塵性ダニ類に対する優れたダニ忌避効果と、人畜に対する高い安全性とを両立させることができる。 The blending ratio (a/b) between the component (a) and the fragrance compound contained in the component (b) is preferably set to 5 to 100, more preferably 5 to 80 on a mass basis. more preferred. When the compounding ratio (a/b) is within the above range, the volatility of (a) 1,8-cineole and/or 1,4-cineol can be effectively adjusted, ensuring high safety. On the other hand, even after a long period of time, an excellent mite repelling effect is exhibited against indoor dust mites. Therefore, it is possible to achieve both an excellent mite repelling effect against indoor dust mites and high safety for humans and animals.
　［その他成分］
　本発明のダニ忌避組成物には、上記の（ａ）成分、及び（ｂ）成分の他に、水、エタノール、イソプロパノールのようなアルコール系溶剤、１,３－ブチレングリコール、プロピレングリコール、ジプロピレングリコールのようなグリコール系溶剤、ジエチレングリコールモノブチルエーテル、プロピレングリコールモノメチルエーテル等のグリコールエーテル系溶剤、ノルマルパラフィン、イソパラフィン等の脂肪族炭化水素系溶剤等の各種溶剤や、界面活性剤（可溶化剤）などを適宜配合することができる。また、本発明のダニ忌避組成物は、上記の（ａ）成分、及び（ｂ）成分の他に、溶剤等の他成分を添加せずに調製することもできる。 [Other ingredients]
In addition to the above components (a) and (b), the tick repellent composition of the present invention contains water, alcoholic solvents such as ethanol and isopropanol, 1,3-butylene glycol, propylene glycol and dipropylene. Various solvents such as glycol solvents such as glycol, glycol ether solvents such as diethylene glycol monobutyl ether and propylene glycol monomethyl ether, aliphatic hydrocarbon solvents such as normal paraffin and isoparaffin, surfactants (solubilizers), etc. can be appropriately blended. The tick repellent composition of the present invention can also be prepared without adding other components such as solvents in addition to the above components (a) and (b).
　界面活性剤としては、例えば、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレン高級アルキルエーテル（ポリオキシエチレンラウリルエーテル、ポリオキシエチレンオレイルエーテル）、ポリオキシエチレン高級脂肪酸エステル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル等の非イオン系界面活性剤や、ラウリルアミンオキサイド、ステアリルアミンオキサイド、ラウリル酸アミドプロピルジメチルアミンオキサイド等の高級アルキルアミンオキサイド系界面活性剤などが挙げられる。上記界面活性剤は、単独で使用してもよいし、二種以上を混合した混合物として使用してもよい。 Examples of surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alkyl ethers (polyoxyethylene lauryl ether, polyoxyethylene oleyl ether), polyoxyethylene higher fatty acid esters, polyoxyethylene polyoxypropylene alkyl ethers. and higher alkylamine oxide surfactants such as laurylamine oxide, stearylamine oxide, and lauramidopropyldimethylamine oxide. The above surfactants may be used alone or as a mixture of two or more.
　また、本発明のダニ忌避組成物には、抗菌成分、防カビ成分、消臭成分、芳香成分、殺虫成分、忌避成分、安定化剤、ｐＨ調整剤、着色剤、ゲル化剤等を適宜配合してもよい。さらに、例えば、「緑の香り」と呼ばれる青葉アルコール（シス－３－ヘキセン－１－オール）や青葉アルデヒド等を添加してもよく、これにより、リラックス効果を付与し、安眠を促すこともできる。 In addition, the tick repellent composition of the present invention is appropriately blended with an antibacterial component, an antifungal component, a deodorant component, an aromatic component, an insecticidal component, a repellent component, a stabilizer, a pH adjuster, a coloring agent, a gelling agent, and the like. You may Furthermore, for example, green leaf alcohol (cis-3-hexene-1-ol), green leaf aldehyde, etc. called "green scent" may be added, thereby imparting a relaxing effect and promoting sound sleep. .
　抗菌成分としては、例えば、イソプロピルメチルフェノール（ＩＰＭＰ）、カルバクロール、チモール、トリクロサン、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン、４－クロロ－３,５－ジメチルフェノール、オルトフェニルフェノール、о－クレゾール、ｍ－クレゾール、及びｐ－クレゾール等のフェノール系抗菌成分、ベンザルコニウムクロライド、ベンザルコニウムメトサルフェート、ベンザルコニウム有機酸塩等のベンザルコニウム塩、ベンゼトニウムクロライド、ベンゼトニウムメトサルフェート、ベンゼトニウム有機酸塩等のベンゼトニウム塩、セチルピリジニウムクロライド、セチルピリジニウムメトサルフェート、セチルピリジニウム有機酸塩等のセチルピリジニウム塩、ジデシルジメチルアンモニウムクロライド、ジデシルジメチルアンモニウムメトサルフェート等のジデシルジメチルアンモニウム塩、ジラウリルジメチルアンモニウムクロライド、ジラウリルジメチルアンモニウムメトサルフェート等のジラウリルジメチルアンモニウム塩、ジステアリルジメチルアンモニウムクロライド、ジステアリルジメチルアンモニウムメトサルフェート等のジステアリルジメチルアンモニウム塩、及び１，４－ビス［３，３´－（１－デシルピリジニウム）メチルオキシ］ブタンジブロマイド、１，４－ビス［３，３´－（１－デシルピリジニウム）メチルオキシ］ブタンジクロライド、１，４－ビス［３，３´－（１－デシルピリジニウム）メチルオキシ］ブタンジメトサルフェート等の１，４－ビス［３，３´－（１－デシルピリジニウム）メチルオキシ］ブタン塩等のカチオン界面活性剤系抗菌成分、ビグワナイド系抗菌成分、テブコナゾール、エニルコナゾール等のアゾール系抗菌成分、グレープフルーツ種子抽出物、カキ種子抽出物、ブドウ種子抽出物等の果物種子抽出物系抗菌成分、モノラウリン、モノカプリン、モノカプリリン等のグリセリンモノ脂肪酸エステル系抗菌成分、クロルヘキシジングルコン酸塩、クロルヘキシジン塩酸塩等のクロルヘキシジン塩やクロルヘキシジン等のクロルヘキシジン系抗菌成分、オクタデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ドデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ドデシルジイソプロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド、テトラデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、テトラデシルジエチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、テトラデシルジ－ｎ－プロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ペンタデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ペンタデシルジエチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ペンタデシルジ－ｎ－プロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ヘキサデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ヘキサデシルジエチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ヘキサデシルジ－ｎ－プロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド、オクタデシルジエチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、オクタデシルジ－ｎ－プロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド等のケイ素系抗菌成分、安息香酸、サリチル酸、ソルビン酸、エチレンジアミン四酢酸（ＥＤＴＡ）、グリシン、アルキルジエチルアミノグリシン、ポリリジン等のカルボン酸系抗菌成分またはそれらの塩、デヒドロ酢酸、クロラミン、３－ヨード－２－プロピル－Ｎ－ブチルカルバメート（ＩＰＢＣ）、フェノキシエタノール、銀ゼオライト等銀系抗菌成分、ジンクピリチオン、チアミンラウリル硫酸塩、白子たんぱく質、ヒドロキシアルキルキトサン又はその塩等が挙げられる。上記抗菌成分は、単独で使用してもよいし、二種以上を混合した混合物として使用してもよい。 Examples of antimicrobial components include isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methylparaben, ethylparaben, propylparaben, butylparaben, 4-chloro-3,5-dimethylphenol, orthophenylphenol, and o-cresol. , m-cresol, and p-cresol phenolic antibacterial ingredients, benzalkonium chloride, benzalkonium methosulfate, benzalkonium salts such as benzalkonium organic acid salts, benzethonium chloride, benzethonium methosulfate, benzethonium organic acid Benzethonium salts such as salts, cetylpyridinium salts such as cetylpyridinium chloride, cetylpyridinium methosulfate, cetylpyridinium organic acid salts, didecyldimethylammonium salts such as didecyldimethylammonium chloride, didecyldimethylammonium methosulfate, dilauryldimethylammonium chloride, dilauryldimethylammonium salts such as dilauryldimethylammonium methosulfate, distearyldimethylammonium salts such as distearyldimethylammonium chloride and distearyldimethylammonium methosulfate, and 1,4-bis[3,3′-(1 -decylpyridinium)methyloxy]butane dibromide, 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane dichloride, 1,4-bis[3,3'-(1-decylpyridinium) ) 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane salts such as methyloxy]butane dimethosulfate, cationic surfactant antibacterial ingredients such as biguanide antibacterial ingredients, tebuconazole, enyl Azole antibacterial ingredients such as conazole, fruit seed extract antibacterial ingredients such as grapefruit seed extract, oyster seed extract, and grape seed extract, glycerin monofatty acid ester antibacterial ingredients such as monolaurin, monocaprin, and monocaprylin, chlorhexidine Gluconate, chlorhexidine salts such as chlorhexidine hydrochloride, chlorhexidine antibacterial ingredients such as chlorhexidine, octadecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyldiisopropyl (3 -triethoxysilylpropyl)ammonium chloride tetradecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldimethyl ( 3-triethoxysilylpropyl)ammonium chloride, pentadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, hexadecyldimethyl(3-triethoxysilylpropyl) ) ammonium chloride, hexadecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, hexadecyldi-n-propyl (3-triethoxysilylpropyl) ammonium chloride, octadecyldiethyl (3-triethoxysilylpropyl) ammonium chloride, octadecyl di- Silicon-based antibacterial ingredients such as n-propyl (3-triethoxysilylpropyl) ammonium chloride, benzoic acid, salicylic acid, sorbic acid, ethylenediaminetetraacetic acid (EDTA), glycine, alkyldiethylaminoglycine, polylysine and other carboxylic acid-based antibacterial ingredients, or Their salts, dehydroacetic acid, chloramine, 3-iodo-2-propyl-N-butylcarbamate (IPBC), phenoxyethanol, silver-based antibacterial ingredients such as silver zeolite, zinc pyrithione, thiamine lauryl sulfate, milt protein, hydroxyalkylchitosan or its Salt etc. are mentioned. The antibacterial component may be used alone or as a mixture of two or more.
　防カビ成分としては、例えば、イソプロピルメチルフェノール（ＩＰＭＰ）、カルバクロール、チモール、トリクロサン、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン、４－クロロ－３,５－ジメチルフェノール、オルトフェニルフェノール、о－クレゾール、ｍ－クレゾール、及びｐ－クレゾール等のフェノール系防カビ成分、ベンザルコニウムクロライド、ベンザルコニウムメトサルフェート、ベンザルコニウム有機酸塩等のベンザルコニウム塩、ベンゼトニウムクロライド、ベンゼトニウムメトサルフェート、ベンゼトニウム有機酸塩等のベンゼトニウム塩、セチルピリジニウムクロライド、セチルピリジニウムメトサルフェート、セチルピリジニウム有機酸塩等のセチルピリジニウム塩、ジデシルジメチルアンモニウムクロライド、ジデシルジメチルアンモニウムメトサルフェート等のジデシルジメチルアンモニウム塩、ジラウリルジメチルアンモニウムクロライド、ジラウリルジメチルアンモニウムメトサルフェート等のジラウリルジメチルアンモニウム塩、ジステアリルジメチルアンモニウムクロライド、ジステアリルジメチルアンモニウムメトサルフェート等のジステアリルジメチルアンモニウム塩、及び１，４－ビス［３，３´－（１－デシルピリジニウム）メチルオキシ］ブタンジブロマイド、１，４－ビス［３，３´－（１－デシルピリジニウム）メチルオキシ］ブタンジクロライド、１，４－ビス［３，３´－（１－デシルピリジニウム）メチルオキシ］ブタンジメトサルフェート等の１，４－ビス［３，３´－（１－デシルピリジニウム）メチルオキシ］ブタン塩等のカチオン界面活性剤系防カビ成分、ビグワナイド系防カビ成分、テブコナゾール、エニルコナゾール等のアゾール系防カビ成分、グレープフルーツ種子抽出物、カキ種子抽出物、ブドウ種子抽出物等の果物種子抽出物系防カビ成分、モノラウリン、モノカプリン、モノカプリリン等のグリセリンモノ脂肪酸エステル系防カビ成分、クロルヘキシジングルコン酸塩、クロルヘキシジン塩酸塩等のクロルヘキシジン塩やクロルヘキシジン等のクロルヘキシジン系防カビ成分、オクタデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ドデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ドデシルジイソプロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド、テトラデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、テトラデシルジエチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、テトラデシルジ－ｎ－プロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ペンタデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ペンタデシルジエチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ペンタデシルジ－ｎ－プロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ヘキサデシルジメチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ヘキサデシルジエチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、ヘキサデシルジ－ｎ－プロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド、オクタデシルジエチル（３－トリエトキシシリルプロピル）アンモニウムクロライド、オクタデシルジ－ｎ－プロピル（３－トリエトキシシリルプロピル）アンモニウムクロライド等のケイ素系防カビ成分、安息香酸、サリチル酸、ソルビン酸、エチレンジアミン四酢酸（ＥＤＴＡ）、グリシン、アルキルジエチルアミノグリシン、ポリリジン等のカルボン酸系防カビ成分又はそれらの塩、デヒドロ酢酸、クロラミン、３－ヨード－２－プロピル－Ｎ－ブチルカルバメート（ＩＰＢＣ）、フェノキシエタノール、銀ゼオライト等銀系防カビ成分、ジンクピリチオン、チアミンラウリル硫酸塩、白子たんぱく質、ヒドロキシアルキルキトサン又はその塩、防カビ香料等が挙げられる。上記防カビ成分は、単独で使用してもよいし、二種以上を混合した混合物として使用してもよい。 Antifungal components include, for example, isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methylparaben, ethylparaben, propylparaben, butylparaben, 4-chloro-3,5-dimethylphenol, orthophenylphenol, o- Phenolic antifungal ingredients such as cresol, m-cresol, and p-cresol, benzalkonium salts such as benzalkonium chloride, benzalkonium methosulfate, and benzalkonium organic acid salts, benzethonium chloride, benzethonium methosulfate, benzethonium Benzethonium salts such as organic acid salts, cetylpyridinium salts such as cetylpyridinium chloride, cetylpyridinium methosulfate, cetylpyridinium organic acid salts, didecyldimethylammonium salts such as didecyldimethylammonium chloride and didecyldimethylammonium methosulfate, dilauryl dimethylammonium chloride, dilauryldimethylammonium salts such as dilauryldimethylammonium methosulfate, distearyldimethylammonium salts such as distearyldimethylammonium chloride and distearyldimethylammonium methosulfate, and 1,4-bis[3,3'- (1-decylpyridinium) methyloxy]butane dibromide, 1,4-bis[3,3′-(1-decylpyridinium)methyloxy]butane dichloride, 1,4-bis[3,3′-(1- 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane salts such as decylpyridinium)methyloxy]butane dimethosulfate, cationic surfactant-based antifungal ingredients, biguanide-based antifungal ingredients , tebuconazole, enirconazole, etc., fruit seed extract-based anti-mold components, such as grapefruit seed extract, persimmon seed extract, grape seed extract, glycerin monofatty acids such as monolaurin, monocaprin, monocaprylin, etc. Ester antifungal ingredients, chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride, chlorhexidine antifungal ingredients such as chlorhexidine, octadecyldimethyl (3-triethoxysilylpropyl) ammonium chloride, dodecyldimethyl (3-triethoxysilylpropyl) ) ammonium chloride, dodecyldiisopropyl (3-triethoxysilylpropyl) ammonium chloride, tetradecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldimethyl (3-triethoxysilylpropyl)ammonium chloride, pentadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, hexadecyldimethyl(3-triethoxysilyl) propyl)ammonium chloride, hexadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, hexadecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, octadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, octadecyldi -Silicone-based antifungal ingredients such as n-propyl(3-triethoxysilylpropyl)ammonium chloride, carboxylic acid-based antifungal ingredients such as benzoic acid, salicylic acid, sorbic acid, ethylenediaminetetraacetic acid (EDTA), glycine, alkyldiethylaminoglycine, and polylysine Mold components or their salts, dehydroacetic acid, chloramine, 3-iodo-2-propyl-N-butylcarbamate (IPBC), phenoxyethanol, silver-based anti-mold components such as silver zeolite, zinc pyrithione, thiamine lauryl sulfate, milt protein, hydroxyl Alkyl chitosan or its salt, antifungal perfume, and the like. The antifungal component may be used alone or as a mixture of two or more.
　消臭成分としては、例えば、植物由来消臭成分等が挙げられる。植物由来消臭成分としては、イネ科、ツバキ科、イチョウ科、モクセイ科、クワ科、ミカン科、キントラノオ科、カキノキ科等の植物から抽出した植物抽出物が挙げられる。上記植物抽出物は、単独で使用してもよいし、二種以上を混合した混合物として使用してもよいが、代表的には、緑茶抽出物や柿抽出物が挙げられる。 Examples of deodorant components include plant-derived deodorant components. The plant-derived deodorant components include plant extracts extracted from plants of the family Gramineae, Theaceae, Ginkgoaceae, Oleaceae, Moraceae, Rutaceae, Chrysanthemum family, Persimmon family, and the like. The above plant extracts may be used singly or as a mixture of two or more, but representative examples include green tea extracts and persimmon extracts.
　ゲル化剤としては、例えば、カラギーナン、キサンタンガム、ジェランガム、ゼラチン、オクチル酸アルミニウム、１２－ヒドロキシステアリン酸等が挙げられる。上記ゲル化剤は、単独で使用してもよいし、二種以上を混合した混合物として使用してもよい。 Examples of gelling agents include carrageenan, xanthan gum, gellan gum, gelatin, aluminum octylate, 12-hydroxystearic acid and the like. The gelling agent may be used alone or as a mixture of two or more.
＜ダニ忌避製品＞
　本発明のダニ忌避製品は、上述した本発明のダニ忌避組成物を含有するものであり、使用場面や消費者のニーズに合わせて、固形状、液状、ゲル状等の種々形態に調製することができる。中でも、ダニ忌避組成物を固形担体に含浸又は保持させたものを通気性材料に収納又は包装した製品形態が好ましい。かかるダニ忌避製品は、枕やクッション、あるいは布団やマット等の下又は付近に設置するだけで、固形担体からダニ忌避成分が効果的に揮散するので、低コストでありながら、屋内塵性ダニ類に対する優れたダニ忌避効果と、人畜に対する高い安全性とを備えたダニ忌避製品を実現することができる。 <Mite Repellent Products>
The tick-repellent product of the present invention contains the above-described tick-repellent composition of the present invention, and can be prepared in various forms such as solid, liquid, gel, etc., according to the scene of use and consumer needs. can be done. Among them, a product form in which a solid carrier is impregnated or held with a tick-repellent composition and housed or packaged in an air-permeable material is preferable. Such a mite repellent product effectively volatilizes the mite repellent component from the solid carrier simply by placing it under or near a pillow, cushion, futon, mat, etc., so that it is low cost and can prevent indoor dust mites. It is possible to realize a tick-repellent product that has an excellent tick-repellent effect against ticks and high safety for humans and animals.
　固形担体としては、セルロース製パルプ等のパルプ、リンター、レーヨン等の繊維質担体、セルロース（再生セルロース）製ビーズもしくは発泡体、ケイ酸塩、シリカ、ゼオライト等の無機多孔質担体、トリオキサン、アダマンタン等の昇華性担体等が挙げられる。これらのうち、セルロース製パルプ等のパルプ、リンター、レーヨン等の繊維質担体、セルロース（再生セルロース）製ビーズが好ましく、セルロース製パルプがより好ましい。 Examples of solid carriers include pulp such as cellulose pulp, fibrous carriers such as linters and rayon, cellulose (regenerated cellulose) beads or foams, inorganic porous carriers such as silicates, silica and zeolite, trioxane, adamantane, and the like. and the like. Among these, pulp such as cellulose pulp, fibrous carriers such as linter and rayon, and cellulose (regenerated cellulose) beads are preferred, and cellulose pulp is more preferred.
　固形担体をビーズ（粒状体）とする場合、その平均粒径は、通常、１～８ｍｍであり、３～８ｍｍが好ましく、４～７ｍｍがより好ましい。固形担体の見掛け比重は、通常、０．１０～０．３５程度であり、０．１５～０．３０が好ましい。例えば、セルロース製パルプ１ｇあたりに、前記（ａ）１，８－シネオール及び／又は１，４－シネオールを２０～４００ｍｇ程度、好ましくは３０～３００ｍｇ含有させ、これを通気性包材に収納すれば、有用、かつ実用性の高い本発明のダニ忌避製品が得られる。 When the solid carrier is beads (granules), the average particle size is usually 1 to 8 mm, preferably 3 to 8 mm, more preferably 4 to 7 mm. The apparent specific gravity of the solid carrier is usually about 0.10 to 0.35, preferably 0.15 to 0.30. For example, about 20 to 400 mg, preferably 30 to 300 mg, of (a) 1,8-cineol and/or 1,4-cineole are contained in 1 g of cellulose pulp, and this is contained in an air-permeable packaging material. , a useful and highly practical mite repellent product of the present invention can be obtained.
　通気性包材としては、不織布袋、綿袋、ネットケース、有孔プラスチック製容器等が挙げられる。これらのうち、使い易さの点で、不織布袋が好ましい。不織布袋の材質としては、例えば、ポリエステル（ＰＥＴ）、ポリエチレン（ＰＥ）、ポリプロピレン（ＰＰ）、ポリアミド、ポリ乳酸、レーヨン等が挙げられる。不織布袋は、単一の繊維で構成してもよいし、あるいは紙を積層したポリエステルやポリプロピレン／レーヨンのような積層品や混紡品であっても構わない。なかでも、前記（ａ）１，８－シネオール及び／又は１，４－シネオールを一部吸着することにより、その揮散量を二次的に調節し得る点で、ポリエステル、ポリエチレン、及びポリプロピレンが好ましい。不織布袋の形状や構成も適宜決定することができ、例えば、両面を前記材質の不織布で構成してもよいし、あるいは、一方の面を前記材質の不織布とし、他方の面を多数の小孔を有するプラスチックフィルムとし、これらを貼り合わせたものとしてもよい。 Breathable packaging materials include non-woven bags, cotton bags, net cases, perforated plastic containers, and the like. Among these, the non-woven fabric bag is preferable in terms of ease of use. Examples of materials for the non-woven fabric bag include polyester (PET), polyethylene (PE), polypropylene (PP), polyamide, polylactic acid, rayon, and the like. The nonwoven bag may consist of a single fiber, or it may be a laminate or blend such as paper laminated polyester or polypropylene/rayon. Among them, polyester, polyethylene, and polypropylene are preferable in that the vaporization amount can be secondarily adjusted by partially adsorbing (a) 1,8-cineole and/or 1,4-cineole. . The shape and configuration of the non-woven fabric bag can also be determined as appropriate. For example, both sides may be made of the non-woven fabric of the above material, or one side may be made of the non-woven fabric of the above material and the other side may be made of a large number of small holes. It is also possible to use a plastic film having
　このようにして得られた本発明のダニ忌避製品の適用場所は、特に限定されないが、カーペット、畳、枕、クッション、布団、マット等の下又は付近に設置して使用することができ、中でも、枕、クッション、布団、マット等の寝具用として使用するのに適している。枕やクッション、あるいは布団やマット等の下又は付近に設置すれば、固形担体から通気性材料を介してダニ忌避成分が揮散し、コナダニ、ヒョウヒダニ、ホコリダニ、ツメダニ等の屋内塵性ダニ類はもちろん、ゾウムシ、カツオブシムシ、チャタテムシ、シバンムシ、ゴキブリ、アリ類、蚊類、蚋、ユスリカ類、ハエ類、チョウバエ類、イガ類などの各種害虫に対して１カ月～６カ月の長期間にわたり実用的な忌避効果を奏するものとなる。本発明のダニ忌避製品は、特に、コナダニ、ヒョウヒダニ、ホコリダニ、ツメダニ等の屋内塵性ダニ類に対して、効果的に忌避効果を発揮することができる。 The application place of the mite repellent product of the present invention obtained in this way is not particularly limited, but it can be used under or near carpets, tatami mats, pillows, cushions, futons, mats, etc. , pillows, cushions, futons, and mats. When placed under or near pillows, cushions, futons, mats, etc., the mite-repellent component volatilizes from the solid carrier via the breathable material, and indoor dust mites such as Acarina pygmaea, leopard dust mites, dust mites, and cheyletid mites. , weevil, deer beetle, bookworm, beetle, cockroach, ants, mosquitoes, worms, chironomids, flies, butterfly flies, mussels, and other pests for a long period of 1 to 6 months. It will be effective. The mite-repellent product of the present invention can effectively repel indoor dust mites, such as acarid mites, house dust mites, dust mites, and cheyletid mites.
　以下、実施例により本発明を具体的に説明する。 The present invention will be specifically described below with reference to examples.
〔実施例１〕
　（ａ）成分として１，８－シネオール４００ｍｇ、及び（ｂ）成分として３－メチル－５－フェニル－１－ペンタノール８ｍｇをそのまま混合し、ダニ忌避組成物を調製した。このダニ忌避組成物全量を、平均粒径が５．５ｍｍ、見掛け比重が０．２１のセルロース製パルプ粒約８ｇに含浸させた。そして、ダニ忌避組成物を含浸させたセルロース製パルプ粒を、両面が通気性のポリエチレン・ポリプロピレンの混合不織布からなる不織布袋（９×１２ｃｍ）に収納し、実施例１のダニ忌避製品を得た。 [Example 1]
400 mg of 1,8-cineole as component (a) and 8 mg of 3-methyl-5-phenyl-1-pentanol as component (b) were mixed as they were to prepare a tick repellent composition. About 8 g of cellulose pulp particles having an average particle size of 5.5 mm and an apparent specific gravity of 0.21 were impregnated with the entire amount of this tick repellent composition. Then, the cellulose pulp granules impregnated with the mite-repellent composition were placed in a non-woven fabric bag (9×12 cm) both sides of which were made of a polyethylene-polypropylene mixed non-woven fabric with air permeability to obtain a mite-repellent product of Example 1. .
〔実施例２～１１、比較例１～２、参考例１～３〕
　表１に示す配合で、（ａ）成分及び（ｂ）成分を含むダニ忌避組成物を実施例１に準じて調製し、実施例１と同様の手順にて、実施例２～１１、比較例１～２、及び参考例１～３の各種ダニ忌避製品を得た。 [Examples 2-11, Comparative Examples 1-2, Reference Examples 1-3]
A mite-repellent composition containing components (a) and (b) with the formulation shown in Table 1 was prepared according to Example 1, and the same procedure as in Example 1 was used to prepare Examples 2 to 11 and Comparative Examples. Various mite repellent products of 1 to 2 and Reference Examples 1 to 3 were obtained.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
［ダニ忌避効力試験］
　実施例１～１１、比較例１～２、及び参考例１～３の各ダニ忌避製品をウール毛布でくるみ、この上に４ｋｇの重石を載せて室温条件下に２ヵ月静置し、その後、各ダニ忌避製品を回収した。 [Tick repellent efficacy test]
Each of the tick repellent products of Examples 1-11, Comparative Examples 1-2, and Reference Examples 1-3 was wrapped in a wool blanket, a weight of 4 kg was placed on it, and the product was allowed to stand at room temperature for 2 months. Each tick repellent product was collected.
　次に、５０ｃｍ四方の綿布の中央に、供試ヤケヒョウヒダニ約１０００００匹を含む培地を均一に撒いた。上記の２ヵ月静置後の各ダニ忌避製品を枕の上に設置して枕カバーで覆い、その表面に誘引用培地１ｇを撒いた後、この枕を前述の綿布の中央に静置し、これを処理区とした。また、ダニ忌避製品を設置しない枕を用いて同様の作業を行い、これを無処理区とした。そして、２４時間後に枕カバー上に侵入したダニ数を計数し、次式に従ってダニ忌避効力（忌避率）を算出した。
　　ダニ忌避効力（％）　＝　（Ｎ０－Ｎ１）／Ｎ０　×　１００
　　　Ｎ０：無処理区の侵入ダニ数
　　　Ｎ１：処理区の侵入ダニ数 Next, a medium containing about 100,000 Dermatophagoides farinae to be tested was uniformly sprinkled on the center of a 50 cm square cotton cloth. Place each mite repellent product after standing for two months on a pillow, cover with a pillow cover, sprinkle 1 g of an attracting medium on the surface, and then place the pillow in the center of the cotton cloth, This was used as a treatment area. In addition, the same operation was performed using a pillow without a mite repellent product, and this was designated as an untreated area. After 24 hours, the number of mites that had invaded the pillow cover was counted, and the mites repelling effect (repelling rate) was calculated according to the following formula.
Tick repellent efficacy (%) = (N 0 - N 1 )/N 0 × 100
N 0 : Number of invaded mites in untreated area N 1 : Number of invaded mites in treated area
　ダニ忌避効力試験の結果を表２に示す。 Table 2 shows the results of the tick repellent efficacy test.
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
　実施例１～１１のダニ忌避製品は、何れも２ヵ月後においても８０％以上の優れたダニ忌避効果を示すことが分かった。これは、ｌｏｇＰ値が２．０～５．５である香料化合物を含む（ｂ）成分が、（ａ）１，８－シネオール及び／又は１，４－シネオールの揮散を効果的に調整したため、実施例１～１１のダニ忌避製品において長期間経過後においても優れたダニ忌避効果を実現したと考えられる。中でも、（ａ）１，８－シネオールと、ｌｏｇＰ値が３．０～５．０である香料化合物を含む（ｂ）成分とを含有した実施例１、３～７、１０及び１１のダニ忌避製品は、何れも２ヵ月後においても８５％以上のダニ忌避効果を示し、より優れていることが判明した。 It was found that the tick repellent products of Examples 1 to 11 all exhibited an excellent tick repellent effect of 80% or more even after 2 months. This is because the (b) component containing a perfume compound with a logP value of 2.0 to 5.5 effectively adjusted the volatilization of (a) 1,8-cineole and/or 1,4-cineol. It is believed that the tick repellent products of Examples 1 to 11 achieved excellent mite repellent effects even after a long period of time. Among them, the tick repellents of Examples 1, 3 to 7, 10 and 11 containing (a) 1,8-cineole and (b) component comprising a fragrance compound having a logP value of 3.0 to 5.0 All of the products showed 85% or more of the mite repelling effect even after 2 months, and were found to be superior.
　一方、（ｂ）成分として、ｌｏｇＰ値が５．５を上回るシクロヘキサデカノリド（ｌｏｇＰ値：５．７）を配合した参考例１のダニ忌避製品や、ｌｏｇＰ値が２．０を下回る酢酸ブチル（ｌｏｇＰ値：１．８）を配合した参考例２のダニ忌避製品は、実施例１～１１のダニ忌避製品と比べて、長期間経過後におけるダニ忌避効果が低下した。ｌｏｇＰ値が２．０～５．５から外れる香料化合物では、１，８－シネオールの揮散の調整がやや劣ることが原因と考えられる。実施例１～１１と参考例１～３との対比から、（ａ）１，８－シネオール及び／又は１，４－シネオールに、ｌｏｇＰ値が２．０～５．５である香料化合物を含む（ｂ）成分を配合することにより、長期間経過後におけるダニ忌避効果をより向上させることが可能となることが分かった。 On the other hand, as the component (b), the mite repellent product of Reference Example 1 containing cyclohexadecanolide (logP value: 5.7) with a logP value of more than 5.5, or acetic acid with a logP value of less than 2.0 The mite repellent product of Reference Example 2, which contained butyl (logP value: 1.8), had a reduced mite repellent effect after a long period of time compared to the mite repellent products of Examples 1 to 11. The reason for this is thought to be that the control of volatilization of 1,8-cineol is slightly poor in perfume compounds having a logP value outside the range of 2.0 to 5.5. From the comparison between Examples 1 to 11 and Reference Examples 1 to 3, (a) 1,8-cineole and/or 1,4-cineol contains a fragrance compound having a logP value of 2.0 to 5.5. It was found that by adding the component (b), it is possible to further improve the mite repelling effect after a long period of time.
　また、（ａ）成分として他のシトロネラールやベチパー油を配合した比較例１及び比較例２のダニ忌避製品は、ｌｏｇＰ値が２．０～５．５である香料化合物を含む（ｂ）成分を配合しても、長期間経過後においてダニ忌避効果が不十分であった。このことから、（ｂ）成分に含まれるｌｏｇＰ値が２．０～５．５である香料化合物が害虫忌避成分の揮散を効果的に調整する現象は、（ａ）１，８－シネオール及び／又は１，４－シネオールに対して特有のものであると考えられる。 In addition, the mite repellent products of Comparative Examples 1 and 2, which contain other citronellal and vetiver oil as the component (a), contain the component (b) containing a fragrance compound having a logP value of 2.0 to 5.5. Even when blended, the mite-repellent effect was insufficient after a long period of time. From this, the phenomenon that the fragrance compound with a logP value of 2.0 to 5.5 contained in the component (b) effectively adjusts the volatilization of the pest repellent component is due to (a) 1,8-cineole and/or or is thought to be unique to 1,4-cineol.
　本発明のダニ忌避組成物、及びダニ忌避製品は、寝具に潜む屋内塵性ダニ類を忌避する用途（寝具用のダニ忌避組成物、及びダニ忌避製品）として好適に利用できるが、屋内塵性ダニ類だけでなく、広範な害虫を忌避する用途にも当然に利用可能である。 The mite repellent composition and mite repellent product of the present invention can be suitably used for repelling indoor dust mites hidden in bedding (mite repellent composition for bedding and mite repellent product). Naturally, it can be used for repelling not only mites but also a wide range of insect pests.

Claims (6)

  1. 　（ａ）１，８－シネオール及び／又は１，４－シネオールと、
    　（ｂ）香料成分と、
    を含有するダニ忌避組成物であって、
    　前記香料成分は、ｌｏｇＰ値が２．０～５．５である香料化合物を一種又は二種以上含むダニ忌避組成物。     (a) 1,8-cineole and/or 1,4-cineole,
    (b) a perfume ingredient;
    A tick repellent composition containing
    The tick repellent composition, wherein the fragrance component comprises one or more fragrance compounds having a logP value of 2.0 to 5.5.
  2. 　前記（ａ）成分と前記（ｂ）成分に含まれる前記香料化合物との配合比（ａ／ｂ）は、質量ベースで５～１００に設定されている請求項１に記載のダニ忌避組成物。 The mite repellent composition according to claim 1, wherein the compounding ratio (a/b) of the component (a) and the fragrance compound contained in the component (b) is set to 5 to 100 on a mass basis.
  3. 　前記（ｂ）成分に含まれる前記香料化合物は、ケイ皮酸エチル、カプロン酸アリル、３－メチル－５－フェニル－１－ペンタノール、シトロネロール、δ－ドデカラクトン、β－イオノン、安息香酸ベンジル、酢酸リナリル、酢酸ゲラニル、プロピオン酸トリシクロデセニル、サリチル酸ベンジル、リモネン、及びサリチル酸アミルからなる群から選択される少なくとも一つである請求項１又は２に記載のダニ忌避組成物。 The fragrance compounds contained in the component (b) include ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, δ-dodecalactone, β-ionone, benzyl benzoate, 3. The tick repellent composition according to claim 1 or 2, which is at least one selected from the group consisting of linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene and amyl salicylate.
  4. 　請求項１～３の何れか一項に記載のダニ忌避組成物を含有する固形担体と、
    　前記固形担体を収納又は包装する通気性包材と、
    を含むダニ忌避製品。     a solid carrier containing the tick repellent composition according to any one of claims 1 to 3;
    a breathable packaging material for housing or packaging the solid carrier;
    Tick repellent products containing.
  5. 　前記固形担体は、平均粒子径が１～８ｍｍである粒状体である請求項４に記載のダニ忌避製品。 The tick repellent product according to claim 4, wherein the solid carrier is a granular material with an average particle size of 1 to 8 mm.
  6. 　前記固形担体は、前記（ａ）成分を１ｇあたり２０～４００ｍｇ含有する請求項４又は５に記載のダニ忌避製品。 The tick repellent product according to claim 4 or 5, wherein the solid carrier contains 20 to 400 mg of component (a) per 1 g.
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