JP2008169164A - Agent for improving effect of pyrethroidal depulization agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a pyrethroidal depulization agent containing a pyrethroidal compound having excellent safety to mammals as a depulization component and exhibiting satisfactory depulization effect and aftereffect in the case of applying residual treatment against fleas. <P>SOLUTION: The effect improving agent for pyrethroidal depulization agents contains, as an active component for improving the depulization effect, a normal paraffin solvent containing ≥20 mass% fraction having a carbon number of ≥14 or an isoparaffin solvent containing ≥60 mass% fraction having a carbon number of ≥16. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

The present invention relates to an efficacy enhancer for a pyrethroid rodenticide.

In recent years, with the increasing number of pets such as cats and dogs indoors, pupae, especially cat fleas, have spread and caused bite and other damage. Pest control is mainly larva countermeasures, and a method of spraying pyrethroid or carbamate insecticide under tatami mats or carpets is usually adopted, but there is a concern that using dust will be time consuming and dirty the room. is there. Also, the control effect of pyrethroids and carbamate insecticides against moths is not as sharp as flying insects such as mosquitoes and flies. This is because moths belong to the class of crypts and are different from insects such as mosquitoes and flies. In addition, when moths are targeted, in addition to direct treatment against adults, it is effective for the purpose of combating larvae. This is considered to be because the residual treatment greatly affects the control effect.

Therefore, development aimed at pesticides has also been attempted. For example, Japanese Patent No. 2739231 (Patent Document 1) contains bis (2,3,3,3-tetrachloropropyl) ether as an active ingredient. However, there is a concern that this active ingredient accumulates in human livestock and causes residual toxicity. Japanese Patent Application Laid-Open No. 2001-348301 (Patent Document 2) describes a flea control solution for animals containing a myristic acid ester together with a flea control component and a solvent. However, this flea control solution is applied to the body surface of cats and dogs, and myristic acid ester is used to increase the diffusibility of the flea control component on the body surface. It is said to be good.

The method of applying a flea control solution to the body surface of cats and dogs is a direct and effective method for controlling wrinkles, but cannot completely eliminate the problems of dermal toxicity and irritation to animals. For this reason, it can be said that the slaughter system which applies a rodenticide around cats and dogs and around the bed and controls the rods has great merit.
Under such circumstances, there is a demand for the development of a preparation that can provide a satisfactory killing effect and residual effect even when the residue treatment is performed on the straw.
Japanese Patent No. 2739231 JP 2001-348301 A

The present invention employs a pyrethroid compound that is excellent in safety against human animals as a slaughtering ingredient, and even when subjected to residual treatment on the pupa, a pyrethroid system that can exhibit a satisfactory slaughtering effect and residual effect It was made for the purpose of providing rodenticides.

In order to solve the above-mentioned problems, the present inventors have conducted extensive research and have completed the present invention as a result of various tests. That is, the present invention adopts the following configuration.
(1) Effective in enhancing the killing effect of a normal paraffin solvent having a ratio of 14 or more carbon atoms in a carbon number distribution of 20% by mass or an isoparaffin solvent having a ratio of 16 or more carbon atoms of 60% by mass or more. Efficacy enhancer of pyrethroid type rodenticide contained as an ingredient.
(2) The pyrethroid rodenticide efficacy enhancer according to (1), wherein the killing component of the pyrethroid rodenticide is imiprothrin and / or phthalthrin.
(3) The efficacy of the pyrethroid rodenticide according to (1) or (2), wherein a lower alkyl ester having 1 to 4 carbon atoms of a higher fatty acid having 14 to 18 carbon atoms is further blended as a component that enhances the killing effect. Enhancer.

The pyrethroid rodenticide provided by the present invention contains a component that can sufficiently enhance the rodenticidal effect, and exhibits a satisfactory rodenticidal effect and residual effect even when a residual treatment is applied to the rod. It is extremely practical.

In the present invention, a pyrethroid compound is used as a slaughtering component from the viewpoint of safety against livestock. Examples of pyrethroid compounds include allethrin, praretrin, framethrin, pyrethrin, imiprothrin, phthalthrin, resmethrin, phenothrin, cyphenothrin, permethrin, empentrin, transfluthrin, methfluthrin, and the like. And imiprothrin and / or phthalthrin is preferred. These compounds include optical isomers or geometric isomers based on the three-dimensional structure of the cyclopropanecarboxylic acid or alcohol moiety, but these and any mixtures thereof are all included in the present invention. is there.

In the present invention, in order to sharply enhance the killing effect of the pyrethroid rodenticide, the ratio of carbon number 14 or more in the carbon number distribution is 20% by mass or more, or the ratio of carbon number 16 or more. It is characterized by blending 60% by mass or more of isoparaffinic solvent.
The effect of kerosene on insecticidal effects on cockroaches has already been investigated in detail, and normal paraffins with 13 carbon atoms contribute most effectively to the efficacy of pyrethroid insecticides, and contribute to the development of efficacy as the carbon number increases beyond 13. However, isoparaffin has been reported to be less effective than normal paraffin.
However, when the present inventors actually performed a test on the cocoon, unlike the cockroach, the ratio of 14 or more carbon atoms is 20% by mass or more, and the ratio of 16 or more carbon atoms. It has been found that an isoparaffinic solvent having a content of 60% by mass or more is remarkably effective. Although the reason for this is not clearly understood, it is considered that the skin permeability of drugs due to differences in insect species is involved.

Specific examples of the normal paraffin solvent used in the present invention include neothiozole, deotomisol, and solvent H, while isoparaffin solvents include, but are not limited to, IP solvent 2835 and the like. In addition, you may add suitably other solvents, such as a naphthene type solvent, propylene glycol, 1, 3- butylene glycol, various silicone oils, and water, as long as the meaning of this invention is not prevented.

In the present invention, it is preferable to further blend a lower alkyl ester having 1 to 4 carbon atoms of a higher fatty acid having 14 to 18 carbon atoms as a component that enhances the killing effect.
Japanese Patent Laid-Open No. 2001-348301 (Patent Document 2) describes that myristic acid esters can increase the diffusibility of flea control components on the body surface of cats and dogs. It has not been verified.
However, according to the test results of the present inventors, the lower alkyl ester having 1 to 4 carbon atoms of the higher fatty acid having 14 to 18 carbon atoms is blended in an amount of 1.0 to 50 times with respect to the pyrethroid killing ingredient. It has been found that when used together with the solvent as the active ingredient of the present invention, the efficacy of the pyrethroid rodenticide can be further enhanced.
Examples of such lower alkyl esters of higher fatty acids include methyl myristate, ethyl myristate, isopropyl myristate, butyl myristate, methyl stearate, ethyl stearate, butyl stearate, and ethyl oleate. It is not limited. Of these, isopropyl myristate is preferable because it is easy to use.

Examples of the dosage form of the pyrethroid type rodenticide provided by the present invention include emulsions, oils, suspensions, liquids such as aqueous solvents, solids such as aerosols, powders, granules, and wettable powders. From the viewpoint of usability and convenience, an aerosol is a preferred form.

Aerosols include the above-mentioned solvents as slaughtering efficacy enhancing components and lower alkyl esters of higher fatty acids, synergists and other active ingredients, stabilizers (BHT, BHA, etc.), and fragrances, if necessary. An auxiliary aerosol component is blended to prepare an aerosol stock solution, which is filled into an aerosol container and then filled with a propellant under pressure.
The amount of the rodenticide component in the aerosol is suitably about 0.02 to 1.0% by weight, and either an oily or aqueous aerosol stock solution can be prepared.
In preparing an aqueous aerosol stock solution, in addition to the above components, water, a surfactant (polyoxyethylene alkyl ethers, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, etc.), a dispersant, an auxiliary solvent, In addition, a rust inhibitor (sodium benzoate, ammonium citrate, etc.) or the like may be added as necessary.

Examples of the synergist include N-octylbicycloheptenecarboximide (trade name MGK-264), a mixture of N-octylbicycloheptene dicarboximide and an alkylamine salt of arylsulfonic acid (trade name MGK-5026), Examples include sinepiline 500, octachlorodipropyl ether, piperonyl butoxide, and the like.
In addition, other insecticides and insect repellent components, for example, organic phosphorus agents such as fenitrothion, DDVP, diazinon, carbamate agents such as NAC, MTMC, methoxadiazone, propoxle, organosilicon compounds such as silafluophene, insects such as metoprene, pyriproxyfen, etc. Combining juvenile hormone, antibacterial and antifungal ingredients such as hinokitiol and isopropylmethylphenol, acaricidal ingredients such as methyl 5-chloro-2-trifluoromethanesulfonamide benzoate, repellent ingredients such as diethyltoluamide, and deodorants By doing so, a multi-purpose composition having excellent efficacy can be obtained, and a synergistic effect between drugs can be expected sufficiently.

Examples of the propellant include liquefied petroleum gas, dimethyl ether, and compressed gas (nitrogen, carbon dioxide gas, etc.).
The filling ratio of the aerosol stock solution and the propellant is not particularly limited, but about 20/80 to 65/35 (volume), preferably 30/70 to 60/40 (volume) is appropriate.

An aerosol injection device for injecting an aerosol agent is composed of an aerosol container filled with an aerosol agent, a valve, an actuator attached to a stem portion of the valve, and the actuator is loaded with an injection button including a nozzle. The The aerosol containers are generally 180 mL cans, 300 mL cans, and 450 mL cans. When filling the aerosol agent, the internal pressure of the container is about 0.2 to 0.6 MPa in consideration of the diffusibility of spray particles, preferably , 0.3 to 0.5 MPa is preferable.

Next, the usage method of the pyrethroid type rodenticide of this invention is demonstrated.
For example, in the case of using an aerosol agent, the spray is applied to the cat or dog whereabouts or around the bed so that the amount of the normal paraffin solvent or isoparaffin solvent used in the present invention is about 5 to 50 mL. By performing such treatment, not only adult larvae and larvae attached to the drug die, but also the excellent residual effect of this rodenticide inhibits egg hatching and larval growth over a long period of time. As a result, the density of wrinkles quickly decreases, and wrinkles can be controlled without applying directly to the body surface of cats and dogs.

The pyrethroid-based rodenticide of the present invention is used for flea control, and exhibits high insecticidal effects on flying insects such as mosquitoes and flies, cockroaches such as cockroaches and ants, and indoor dust mites. . In particular, for moth insects that are required to be imparted with residual effects, an extremely effective control means is provided in the same manner as the moth control treatment.

EXAMPLES Next, although an Example and a test example demonstrate this invention further in detail, this invention is not limited to these.

Oily aerosol stock solution (120 mL) by adding about 114 mL of isopropyl myristate 5.0 g, normal paraffinic solvent (trade name: deotomisole, ratio of 14 or more carbon atoms is 26 mass%) to 0.4 g of imiprothrin and 0.7 g of phenothrin Was prepared and filled into aerosol containers. After attaching the valve part, 180 mL of propellant (mixed gas of liquefied petroleum gas and dimethyl ether) was pressurized and filled through the valve part to obtain a pyrethroid rodenticide used in the present invention.
This aerosol was sprayed at 25 mL per square meter on jutan around the cat toilet. By this treatment, the adult cat flea that touched the jumping surface from the cat was lethal, and the density of the larvae that lived in the jutan was rapidly reduced by the excellent killing effect and residual effect of this rodenticide. , Humans no longer suffer from cat fleas.

Surfactant 8.0g, water 30mL, isoparaffinic solvent (trade name: IP solvent 2835, ratio of 16 or more carbon atoms is 93% by mass or more) to 0.5g of d-T80-phthalthrin and 0.03g of cyphenothrin In addition, an aqueous aerosol stock solution (120 mL) was prepared and filled into an aerosol container. After attaching the valve part, 180 mL of a propellant (liquefied petroleum gas) was pressurized and filled through the valve part to obtain a pyrethroid type rodenticide used in the present invention.
This aerosol agent was extremely effective in controlling adult moths and larvae as in Example 1.

The following tests were conducted for each test aerosol obtained in accordance with Example 1.
[Limited time contact method]: The test aerosol agent shown in Table 1 was sprayed on a 20 cm × 20 cm filter paper in an amount of 1 mL (25 mL per 1 m 2) and air-dried for 2 hours. A plastic ring with a diameter of 12 cm containing 20 adult cat fleas prepared in advance was moved onto the filter paper and contacted with the drug for 2 hours. During this period, the number of knockdown insects over time was recorded to determine the KT50 value, and all cat fleas after contact for a predetermined time were transferred to a clean plastic container, and the mortality was examined 24 hours later. The test was conducted 2 hours after spraying and 5 days later. The test results are also shown in Table 1.

As a result of the test, a pyrethroid compound is employed as a killing component, and a normal paraffin compound having a ratio of 14 or more carbon atoms of 20% by mass or more, or an isoparaffin having a ratio of 16 or more carbon atoms of 60% by mass or more is used as an efficacy enhancing component. The pyrethroid-type rodenticide of the present invention containing a solvent based on the present invention showed a high rodenticidal effect and residual effect, and was found to be extremely effective for controlling wrinkles. Moreover, it was much more effective to mix | blend the C1-C4 lower alkyl ester of a C14-C18 higher fatty acid.
On the other hand, as shown in Comparative Examples 1 and 2, when the carbon number distribution of the solvent is not included in the scope of the present invention, the effect of enhancing the efficacy of the pyrethroid killing component is not sufficient, and the utility of the present invention Was confirmed. In addition, as shown in Comparative Examples 3 and 4, the effect of enhancing the efficacy of the rodenticide disclosed by the present invention was not observed in the carbamate agent, and was characteristic of the pyrethroid type rodenticide.
Such characteristics tend to be different from those for cockroaches, and were discovered only after a pharmaceutical preparation test was actually performed on cocoons.

The present invention can be used for the purpose of extensive pest control indoors and outdoors.

Claims (3)

In the carbon number distribution, a normal paraffin solvent having a ratio of 14 or more carbon atoms of 20% by mass or more, or an isoparaffin solvent having a ratio of 16 or more carbon atoms of 60% by mass or more is contained as an active ingredient for enhancing the killing effect. An efficacy enhancer for a pyrethroid rodenticide characterized by The efficacy enhancer for a pyrethroid rodenticide according to claim 1, wherein the killing component of the pyrethroid rodenticide is imiprotorin and / or phthalthrin. The efficacy of the pyrethroid type rodenticide according to claim 1 or 2, further comprising a C 1-4 lower alkyl ester of a higher fatty acid having 14 to 18 carbon atoms as a component that enhances the rodenticide effect. Enhancer.