JP2008063242A - Sanitary insecticide - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To develop a validity enhancer having a quickly knockdown effect to be practically desired by mixing the validity enhancer with an insecticidal component and thereby to obtain a sanitary insecticide exhibiting an excellent practical extermination effect on sanitary insect pests. <P>SOLUTION: The sanitary insecticide comprises (A) a pyrethroid-based insecticide and (B) an ester between a 6-10C fatty acid and a 2-8C alcohol, preferably an ester between a 6-10C saturated fatty acid and a 2-4C alcohol as a validity enhancer. In the preferable embodiment, the sanitary insecticide is an aerosol agent containing a propellant. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a sanitary pest control agent, and more particularly, to a sanitary pest control agent that enhances the control effect against sanitary pests by blending a specific fatty acid ester compound that acts as an efficacy enhancer with an insecticidal component.

  Conventionally, it has been proposed that a composition for controlling sanitary pests is formulated with various potency enhancers, for example, a saturated or unsaturated higher fatty acid having 12 to 18 carbon atoms together with a specific pyrethroid insecticide. Insecticidal composition containing isopropyl ester (see Patent Document 1) and insecticidal composition containing a monocarboxylic acid ester having 16 to 19 carbon atoms and / or a dicarboxylic acid ester having 16 to 19 carbon atoms together with the insecticidal component imiprothrin (patent) Reference 2), an insecticidal component, a mineral oil component, and a liquefiable gas propellant, a saturated or unsaturated aliphatic alcohol having 10 to 30 carbon atoms, an aliphatic monoester having 16 to 18 carbon atoms of glycerol, or propylene glycol Insecticidal compositions containing at least one monostearate (see Patent Document 3) are known.

  However, in such an insecticidal composition, it is desired that a knockdown effect appears promptly practically. However, a higher fatty acid ester having 12 or more carbon atoms as described above may be blended with an insecticidal component. Therefore, the knockdown effect is difficult to appear promptly and the practicality is insufficient.

On the other hand, although it is a wood pest control agent, it has also been proposed that higher alcohols and higher fatty acid esters are effective as control agents for termites that are house pests (see Patent Document 4). However, this wood pest control agent is a wood pest control agent that applies only to termites, which are house pests, and applies, impregnates, etc. to the wood that is the application site, and only contains higher alcohols and / or higher fatty acid esters themselves. It is intended as an active control ingredient and is not intended to enhance the efficacy of other insecticidal ingredients.
JP-A-48-99337 (Claims) Japanese Patent Laid-Open No. 4-9306 (Claims) JP-A-49-93542 (Claims) JP-A-8-133909 (Claims)

  Therefore, the object of the present invention is to develop a potency enhancer that solves the above-mentioned problems and exhibits a rapid knockdown effect that is practically desired by being blended with an insecticidal component, and is therefore practical. Another object of the present invention is to provide a sanitary pest control agent that exhibits an excellent control effect against sanitary pests.

In order to achieve the object, according to the present invention,
(A) pyrethroid insecticide,
(B) an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms,
There is provided a hygiene pest control agent comprising the component (A) and the component (B).

  In a suitable aspect, content of the component (B) with respect to all the solvents is 5-100 mass%. Moreover, in another suitable aspect, the said fatty-acid esterified product is ester of a C6-C10 fatty acid and C2-C4 alcohol. In a more preferred aspect, the sanitary pest control agent is an aerosol agent further containing a propellant.

  The sanitary pest control agent of the present invention is an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms, preferably a fatty acid having 6 to 10 carbon atoms and 2 to 4 carbon atoms, together with a pyrethroid insecticide. Since it contains an ester with alcohol as a potency enhancer, it has a quick knockdown effect on various sanitary pests and exhibits an excellent extermination effect. In particular, when an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 4 carbon atoms is contained as an efficacy enhancer together with a pyrethroid insecticide, a rapid knockdown effect appears for various hygiene pests, It has a very lethal effect and exhibits an excellent extermination effect. In addition, when formulated as an aerosol containing a propellant, it exhibits a quick knockdown effect especially against flies, mosquitoes and flea hygiene pests, as well as an extremely lethal effect and exhibits an excellent extermination effect. To do.

  As a result of intensive studies to develop a potentiating agent that exhibits a rapid knockdown effect that is practically desired by being blended with an insecticidal component, the present inventors have surprisingly found that the conventionally known carbon Even if an alkyl ester of a saturated fatty acid of several tens or more is blended with a pyrethroid insecticide, a clear effect of enhancing efficacy does not appear, but an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms, preferably When an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 4 carbon atoms is blended together with a pyrethroid insecticide, a clear effect of enhancing efficacy appears, and as quickly as practically desired for various sanitary pests. As a result, the present inventors have found that a knockdown effect appears and a lethal effect is high, and the present invention has been completed.

  That is, the sanitary pest control agent of the present invention is a sanitary pest control agent containing a pyrethroid insecticide and a solvent, and instead of at least a part of the solvent, a fatty acid having 6 to 10 carbon atoms and a carbon number 2 to 8 carbon atoms. It is characterized by containing an ester with an alcohol, preferably an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 4 carbon atoms as a potentiator. Since the ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms is liquid, it can be used as a solvent itself (the entire solvent can be the above fatty acid ester product), The fatty acid esterified product can be used instead of a part, and in any case the fatty acid esterified product acts as an efficacy enhancer of the insecticidal component, so that a quick knockdown effect appears for various sanitary pests, It has a high lethal effect and exhibits an excellent extermination effect. The ratio of the ester of the fatty acid having 6 to 10 carbon atoms and the alcohol having 2 to 8 carbon atoms with respect to the whole solvent is 5 to 100% by mass, preferably 10 to 100% by mass, as will be apparent from Test Example 4 described later. A ratio of 10 to 75% by mass is preferable in consideration of economy. When the ratio of the fatty acid ester compound to the whole solvent is less than 5% by mass, the effect of enhancing the efficacy by adding the fatty acid ester compound is difficult to appear.

  Sanitary pests targeted by the present invention include pests that mediate pathogenic microorganisms, pests that cause harm by biting and sucking blood, pests that cause dermatitis and allergic reactions when stabbed, and pests as allergens for allergic diseases , And a pest that gives psychological discomfort and disgust. For example, flies such as house flies, dromedaries, sentinic flies; mosquitoes such as oyster mosquitoes, chikaeka, and tiger mosquitoes; cockroaches such as German cockroaches, black cockroaches, cockroaches; fleas such as fleas Lice such as head lice, body lice, etc .; mites such as house dust mites, claw mites, coral leopard mites; , Chadokuga, etc .; Aoiraga, Hilohelia Oiraga, etc .; It includes the raw pest. Among these, it is particularly effective against flies such as house flies, flies flies, sentinic flies, mosquitoes such as mosquitoes, chikaeka, and human mosquitoes, fleas such as human fleas, cat fleas, etc. It can be used advantageously.

  Examples of pyrethroid insecticides used in the present invention include metfurthrin (trade name of Sumitomo Chemical Co., Ltd .: Eminence, the same applies hereinafter), dl, d-T80-areslin (pinaminforte), phthalusrin (neopinamin), d-T80-phthalthrin (neopinamin forte), d, d-T80-praretrin (Etoc), d, d-T98-praretrin (98 etok), d-T80-resmethrin (chryslon forte), transfluthrin ( Biothrin), Imiprotorin (Pral), Etofenprox (Trevon), Cifenothrin (Gokylato), d, d-T-Cifenotrin (Gokyrat S), Empentrin (Vapersulin), Permethrin (Exmine), Phenothrin (Smithrin) , Piretri Mentioned (Chrysanthemum extract pale), etc., it can be used alone or in combination of two or more.

  Further, among pyrethroid insecticides, metfurthrin, phthalthrin, d-T80-phthalthrin, d, d-T80-praretrin, d, d-T98-praretrin, trans are highly safe and have high pest control efficacy. Pyrethroid insecticides having a high knockdown effect, such as furthrin, imiprothrin, and pyrethrin, are preferably used. In particular, a pyrethroid insecticide having a high knockdown effect and a pyrethroid insecticide having a high lethal effect such as d-T80-resmethrin, ciphenothrin, d, dT-cyphenothrin, phenothrin, etofenprox are used in combination. Is preferred.

  The content of the pyrethroid insecticide in the sanitary pest control agent of the present invention can be appropriately set according to the target pest, application method, etc., and is not particularly limited, but is generally 0.0001 to 5 mass of the total amount of the pesticide. The range of / volume% is suitable, preferably 0.001 to 2 mass / volume%, and more preferably 0.01 to 1 mass / volume%. When the content of the pyrethroid insecticide is less than 0.0001 mass / volume%, it is difficult to obtain a sufficient pest control effect. On the other hand, the upper limit of the content of the insecticidal component is the aspect of the pest control effect, economy, safety, etc. It may be set appropriately in consideration of the balance.

  The sanitary pest control agent of the present invention is an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms, preferably carbon, instead of at least a part of the solvent together with the pyrethroid insecticide as described above. An ester of a fatty acid having a number of 6 to 10 and an alcohol having a carbon number of 2 to 4 is contained as a potentiator. As the ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms, any ester that is liquid at room temperature can be used. For example, ethyl caproate, propyl caproate, isopropyl caproate, butyl caproate, Isobutyl caproate, hexyl caproate, octyl caproate, 2-ethylhexyl caproate, ethyl heptanoate, propyl heptanoate, isopropyl heptanoate, butyl heptanoate, isobutyl heptanoate, hexyl heptanoate, octyl heptanoate, 2-heptanoic acid 2- Ethylhexyl, ethyl caprylate, propyl caprylate, isopropyl caprylate, butyl caprylate, isobutyl caprylate, hexyl caprylate, octyl caprylate, 2-ethylhexyl caprylate, ethyl pelargonate, propelgonate , Isopropyl pelargonate, butyl pelargonate, isobutyl pelargonate, hexyl pelargonate, octyl pelargonate, 2-ethylhexyl pelargonate, ethyl caprate, propyl caprate, isopropyl caprate, butyl caprate, isobutyl caprate, capric acid Hexyl, octyl caprate, 2-ethylhexyl caprate and the like can be mentioned, and these can be used alone or in combination of two or more. Preferably, ethyl caproate, isopropyl caproate, isobutyl caproate, ethyl caprylate, isopropyl caprylate, isobutyl caprylate, ethyl caprate, isopropyl caprate, isobutyl caprate have an excellent knockdown effect on the housefly. More preferably, the fatty acid esterified product such as caproic acid, caprylic acid, capric acid is derived from a vegetable oil such as palm kernel oil or palm oil in terms of reducing petroleum solvent and reducing environmental impact. Good. In addition, about the thing whose alcohol group of the said fatty-acid ester product is a methyl group, although there exists an effect | action potentiating effect effectively, as shown in the test example mentioned later, since an odor is strong, it is not suitable. In addition, esterified products with fatty acids having less than 6 carbon atoms also have a strong ester odor, whereas in the case of esterified products with fatty acids having more than 10 carbon atoms, as will be apparent from Test Example 5 to be described later, sanitary pests. On the other hand, the efficacy enhancing effect is hardly expressed.

  As the solvent used together with the fatty acid ester product, various conventionally known solvents can be used as a pest control solvent, for example, alcohols such as methyl alcohol and ethyl alcohol; diethyl phthalate, isopropyl myristate, stearic acid Esters such as butyl and methyl oleate; aliphatic hydrocarbons such as hexane, kerosene, and paraffin; aromatic hydrocarbons such as benzene and xylene; and ethers such as ethylene glycol and ethylene glycol diethyl ether These can be used alone or in combination of two or more.

The sanitary pest control agent of the present invention is combined with the pyrethroid insecticide as described above, and various agents conventionally used for the purpose of controlling various sanitary pests, such as fenitrothion (Sumithion), malathion (marathon), etc. Organic phosphorus insecticides; carbamate insecticides such as propoxur (Baigon) and carbaryl (NAC); acaricides such as Kelsen, quinomethionate and hexathiazox can be appropriately selected and used according to the sanitary insect pest .
Moreover, the sanitary pest control agent of the present invention includes, as necessary, pest repellent components such as N, N-diethyl-m-toluamide (DET); cassia oil, clove oil, and hiba oil. , Cedarwood oil, Cinnamon leaf oil, Pimento oil, Thyme oil, Citronella oil, Lemongrass oil and other plant essential oils; sorbitan monooleate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene nonylethylphenol Surfactants such as calcium dodecylbenzenesulfonate and polyethylene glycol oleate; synergists such as piperonyl butoxide; antioxidants such as butylhydroxytoluene; bactericides such as benomyl and tetrachloroisophthalonitrile Various natural and artificial incense such as limonene ; May contain an antiseptic agent such as propyl p-hydroxybenzoate.
The content of these components in the sanitary pest control agent is not particularly limited, and the desired effects of these components are exhibited within a range that does not inhibit the expression of the desired effect of the present invention. Any quantitative ratio may be used.

  As the dosage form of the sanitary insect pest control agent according to the present invention, any dosage form such as an aerosol agent, a spray oil agent that sprays the composition using a hand pump, a trigger, a squeeze, etc. may be used, but it can be easily sprayed. From the viewpoint, it is preferable to formulate an aerosol.

  When formulating as an aerosol, liquefied petroleum gas such as normal butane, isobutane, propane, chlorofluorocarbons, dimethyl ether, isopentane, carbon dioxide, compressed air, carbon dioxide, nitrogen, laughing gas, etc. It can be used as a gas. The aerosol agent is different from the method using a spray device such as a hand pump, trigger, squeeze, etc. in that a propellant is used, but the other compositions are basically the same. The blending amount of the propellant can be appropriately set according to the target pest and the like, and is not particularly limited, but is usually 10 to 95% by mass of the total amount of the aerosol agent, and preferably 85% by mass or less.

  On the other hand, when using a spraying device or the like, a hygienic pest control agent is contained in a container, and a pressure spraying device such as a hand pump, a trigger sprayer, an electric pump, or a squeeze is attached to the container. Can be applied. In the case of using a spraying device, unlike the aerosol agent, the air and the sanitary pest control agent can be mixed well by adjusting the spraying mechanism and can be easily sprayed. As the pressure spray mechanism, various mechanisms such as a hand pump, an electric pump, a spray mechanism using compressed gas, and a container having a mechanism capable of forming a foam can be used.

  EXAMPLES Hereinafter, although an Example and a test example are shown and the effect of this invention is demonstrated concretely, it cannot be overemphasized that this invention is not limited to the following Example.

Preparation of fatty acid ester:
Methyl butyrate: Tokyo Chemical Industry's reagent ethyl butyrate: Tokyo Chemical Industry's reagent isopropyl butyrate: Tokyo Chemical Industry's reagent isobutyl butyrate: Tokyo Chemical Industry's reagent normal butyl butyrate: Tokyo Chemical Industry's reagent 2-ethylhexyl butyrate: Tokyo Chemical Industry Reagent methyl caproate: Lion Pastel M-06
Ethyl caproate: Reagents manufactured by Tokyo Chemical Industry Isopropyl caproate: Reagents manufactured by Tokyo Chemical Industry Isobutyl caproate: Reagents manufactured by Tokyo Chemical Industry Normal butyl caproate: Reagents manufactured by Tokyo Chemical Industry Methyl caprylate: Pastel M-08 manufactured by Lion
Ethyl caprylate: Tokyo Kasei Kogyo reagent isopropyl caprylate: Tokyo Kasei Kogyo reagent caprylate isobutyl: Tokyo Kasei Kogyo reagent normal butyl caprylate: Tokyo Kasei Kogyo reagent caprylic acid 2-ethylhexyl: Lion pastel 2H-08
Methyl caprate: Lion Pastel M-10
Ethyl caprate: Tokyo Chemical Industry reagent isopropyl caprate: Tokyo Chemical Industry reagent Isobutyl caprate: Tokyo Chemical Industry reagent normal butyl caprate: Tokyo Chemical Industry reagent methyl laurate: Lion Pastel M-12
Ethyl laurate: Reagent isopropyl laurate manufactured by Tokyo Kasei Kogyo: Reagent manufactured by Tokyo Chemical Industry Isobutyl laurate: Reagent normal butyl laurate manufactured by Tokyo Chemical Industry: Reagent 2-ethylhexyl laurate manufactured by Tokyo Chemical Industry: Pastel 2H-12 manufactured by Lion

Aerosol preparation:
As a sanitary pest control agent, an aerosol agent having the following formulation was prepared.
Insecticidal component: Neopinamine forte 0.45g + Crislon forte 0.06g
Solvent: Neothiozol F (solvent manufactured by Chuo Kasei Co., Ltd .; kerosene (normal paraffin)) 22.5 ml + each test agent (fatty acid ester) 22.5 ml
Propellant: propane gas or LPG 255ml
Liquid / gas ratio: 45/255
Further, as a control sanitary insect pest control agent, an aerosol agent was prepared in the same formulation as above except that only Neothiozol F (45 ml) was used as a solvent without using a fatty acid esterified product.

The pest control efficacy in each of the following test examples was evaluated by the direct spray method. FIG. 1 shows an outline of the apparatus used in the evaluation.
Test insects A (8 animals) were placed in a glass ring 1 (diameter 9 cm × height 6 cm) covered with a 14-mesh net 2 on both sides, and fixed on the table 3. This table 3 was installed in parallel at a predetermined position in a glass cylinder 5 (diameter 20 cm) fixed on the frame 4 so that the surface of the net 2 (opening surface) faces the opening side of the glass cylinder 5. . In the glass cylinder 5, “exhaust” is written from the position marked “spray” in FIG. 1 so that the aerosol contents sprayed on all the test insects in the installed glass ring 1 are hit. A constant amount of air is flowing in the direction of the air. The table 3 to which the glass ring 1 is fixed is placed in the glass cylinder 5 so that aerosol is sprayed from a distance L (spray distance) of 150 cm or 30 cm from the spray side end of the glass cylinder 5 depending on the target pest. installed. The aerosol injection amount was adjusted so that the amount of the insecticidal component was a predetermined amount. The aerosol injection amount was adjusted by using an aerosol automatic micro spray device (manufactured by YASUDA SEIKI SEISAKUSHO LTD) and adjusting the spray time of the device.

Test example 1
A housefly is used as the test insect A, and each aerosol agent is sprayed under the conditions of a spray distance L = 150 cm and a total spray amount of 0.5 g (approx. 0.2 second spray). Counting was performed to determine KT ₅₀ (seconds) by Bliss's Probit method. Table 1 shows the knockdown effect on the housefly. Table 2 shows the lethal effect on the housefly.

Test example 2
For various fatty acid esterified products, a sensory test on odor by 10 monitors was performed. The results are shown in Table 3.
In Tables 1 to 3 below, R ₁ COO represents a fatty acid moiety, and R ₂ represents an alcohol group.

前記表１及び表２に示す結果から明らかなように、本発明に従って処方されたエアゾール剤は、イエバエに対して、対照のエアゾール剤に比べて速やかにノックダウン効果が現れ、また致死効果も著しく高く、炭素数６〜１０の脂肪酸と炭素数２〜８のアルコールとのエステルを殺虫成分と共に配合した場合、顕著な効力増強効果が現われることが確認された。これに対して、炭素数１２の脂肪酸であるラウリン酸のエステル化物（メチル、イソプロピル、イソブチル）を殺虫成分と共に配合した場合、表１に示されるように、対照のエアゾール剤に比べてノックダウン効果が現れるのが極めて遅かった。なお、上記脂肪酸エステル化物のアルコール基がメチル基のものについては、表１及び表２に示されるように効力的には効力増強効果があるが、表３に示されるように臭気が強いため、実用に供することは困難である。また、炭素数６未満の脂肪酸（酪酸）のエステル化物についても、表３に示されるように臭気が強いため、実用に供することは困難である。また、表３に示されるように炭素数１２の脂肪酸（ラウリン酸）のエステル化物は臭気は弱いが、上記の通りイエバエに対するノックダウン効果に劣る。

As is apparent from the results shown in Tables 1 and 2, the aerosol formulated according to the present invention has a knockdown effect on the housefly more rapidly than the control aerosol, and has a marked lethal effect. It was confirmed that when an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms was blended together with an insecticidal component, a remarkable effect of enhancing potency appeared. On the other hand, when an esterified product (methyl, isopropyl, isobutyl) of lauric acid, which is a fatty acid having 12 carbon atoms, is blended with an insecticidal component, as shown in Table 1, it has a knockdown effect as compared with the control aerosol agent. It was very late to appear. In addition, about the thing whose alcohol group of the said fatty-acid ester compound is a methyl group, since it has an effect of potentiating effectiveness effectively as shown in Table 1 and Table 2, since odor is strong as shown in Table 3, It is difficult to put it to practical use. Also, esterified products of fatty acids having less than 6 carbon atoms (butyric acid) have a strong odor as shown in Table 3, and are difficult to put to practical use. Moreover, as shown in Table 3, the esterified product of a C12 fatty acid (lauric acid) has a weak odor, but is inferior in the knockdown effect on the housefly as described above.

Test example 3
As the test worm A, female mosquito mosquitoes were used, and each of the aerosols (using LPG as a propellant) was sprayed with a spray distance L = 150 cm and a total spray amount of 0.2 g (spray for about 0.1 second). After spraying, the number of knockdown insects was counted over time, and KT ₅₀ (seconds) was determined by Bliss's Probit method. In addition, the lethal effect on the squid was measured. The obtained knockdown effect and lethal effect are summarized in Table 4.

前記表４に示す結果から明らかなように、本発明に従って処方されたエアゾール剤（カプリン酸イソプロピル含有）は、アカイエカに対しても、対照のエアゾール剤に比べて速やかにノックダウン効果が現れ、また致死効果も高かったが、炭素数１２の脂肪酸であるラウリン酸のエステル化物（ラウリン酸イソプロピル）を殺虫成分と共に配合した場合、対照のエアゾール剤に比べてノックダウン効果が現れるのが極めて遅かった。

As is apparent from the results shown in Table 4, the aerosol formulation (containing isopropyl caprate) formulated according to the present invention has a knockdown effect on Culex mosquito more quickly than the control aerosol formulation, and Although the lethal effect was also high, when the esterified product of lauric acid (isopropyl laurate), which is a fatty acid having 12 carbon atoms, was combined with an insecticidal component, the knockdown effect appeared very slowly compared to the control aerosol.

Test example 4
In order to investigate the relationship between the ratio of the fatty acid esterified product in the solvent and the knockdown effect (KT ₅₀ ), a housefly is used as the test insect A, and each aerosol agent (using LPG as a propellant) is sprayed. Spraying was performed under the conditions of a distance L = 150 cm and a total spray amount of 0.5 g (spraying for about 0.2 seconds), the number of knockdown insects was counted over time, and KT ₅₀ (seconds) was obtained by Bliss' Probit method.
In a solvent of an esterified product of capric acid (ethyl caprate, isopropyl caprate, isobutyl caprate) and an esterified product of lauric acid (isobutyl laurate, isopropyl laurate) having 12 carbon atoms. Table 5 shows the relationship between the ratio and the knockdown effect (KT ₅₀ ).
The details of the preparation of the aerosol agent, the content of the fatty acid esterified product in the total solvent, and the measuring method thereof are as follows.
Aerosol preparation:
As a sanitary pest control agent, an aerosol agent having the following formulation was prepared.
The content rate with respect to the total solvent of a fatty-acid ester was set with the preparation amount.
Insecticidal component: Neopinamine forte 0.45g + Crislon forte 0.06g
Solvent: Neothiozole F (solvent manufactured by Chuo Kasei Co., Ltd .; kerosene (normal paraffin)) + each test agent (fatty acid ester)
When the ratio of fatty acid ester in all solvents is 5%:
Neothiozol F + each test agent (fatty acid ester product) = 42.75 ml + 2.25 ml
When the ratio of fatty acid ester in all solvents is 10%:
Neothiozol F + each test agent (fatty acid ester) = 40.5 ml + 4.5 ml
When the ratio of fatty acid ester in all solvents is 25%:
Neothiozole F + each test agent (fatty acid ester product) = 33.75 ml + 11.25 ml
When the ratio of fatty acid ester in all solvents is 50%:
Neothiozol F + each test agent (fatty acid ester) = 22.5 ml + 22.5 ml
When the ratio of fatty acid ester in all solvents is 75%:
Neothiozol F + each test agent (fatty acid ester product) = 11.25 ml + 33.75 ml
When the ratio of fatty acid ester in all solvents is 100%:
Neothiozol F + each test agent (fatty acid ester) = 0 ml + 45 ml
Propellant: propane gas or LPG 255ml
Liquid / gas ratio: 45/255
Further, as a control sanitary insect pest control agent, an aerosol agent was prepared in the same formulation as above except that only Neothiozol F (45 ml) was used as a solvent without using a fatty acid esterified product.
Method for measuring content of fatty acid ester compound in all solvents:
0.02g was collected from the solvent prepared with Neothiozol F (Chuo Kasei Co., Ltd. solvent; kerosene (normal paraffin)) + each test agent (fatty acid ester), diluted with 1 g of hexane, and subjected to gas chromatography analysis under the following conditions. Went. Quantification was performed using a calibration curve prepared at a known concentration in advance.
Column: J & W Capillary Column DB-5HT (inner diameter 0.25 mm × length 30 m, film thickness 0.25 μm)
Temperature: 50 → 350 ° C. (temperature increase rate 10 ° C./min)
Carrier gas: He, 30 cm / sec
Inlet: 350 ° C., Split ratio 50: 1, 1 μL
Detection port: FID, 350 ° C

表５に示される結果から明らかなように、炭素数１０の脂肪酸であるカプリン酸のエステル化物（カプリン酸エチル、カプリン酸イソプロピル、カプリン酸イソブチル）は、溶剤全体に対する脂肪酸エステル化物の割合が約５質量％以上で明瞭な効力増強効果が現われ、約７５質量％以上でその効果は飽和状態に近づく。このことから、溶剤全体に対する脂肪酸エステル化物の割合は、５〜１００質量％、好ましくは１０〜１００質量％の割合が適当であり、経済性も考慮すると１０〜７５質量％の割合が好ましい。一方、炭素数１２の脂肪酸であるラウリン酸のエステル化物（ラウリン酸イソブチル、ラウリン酸イソプロピル）は、溶剤全体に対する比率を変化させても明瞭な効力増強効果が表れず、特にラウリン酸イソプロピルの場合には溶剤全体に対する比率を増すほどノックダウン効果（ＫＴ５０）は悪くなった。

As is apparent from the results shown in Table 5, the esterified product of capric acid (ethyl caprate, isopropyl caprate, isobutyl caprate), which is a fatty acid having 10 carbon atoms, has a ratio of fatty acid ester to the total solvent of about 5 A clear effect of potentiating effect appears at mass% or more, and the effect approaches a saturated condition at about 75 mass% or more. From this, the ratio of the fatty acid ester product to the whole solvent is 5 to 100% by mass, preferably 10 to 100% by mass, and considering the economy, the ratio of 10 to 75% by mass is preferable. On the other hand, the esterified product of lauric acid, which is a fatty acid having 12 carbon atoms (isobutyl laurate, isopropyl laurate) does not show a clear effect of enhancing the potency even when the ratio to the whole solvent is changed, especially in the case of isopropyl laurate. The knockdown effect (KT50) worsened as the ratio to the total solvent increased.

Test Example 5
As the test insect A, a house ant that is a house pest is used, and each aerosol agent (using LPG as a propellant) is sprayed at a distance L = 30 cm and a total spray amount 0.9 g (about 0.5 seconds). The number of knockdown insects was counted over time, and KT50 (seconds) was determined by Bliss's Probit method. Table 6 shows the obtained knockdown effect.

前記表６に示す結果から明らかなように、本発明に従って処方されたエアゾール剤（カプリン酸イソプロピル含有）及び炭素数１２の脂肪酸であるラウリン酸のエステル化物（ラウリン酸イソプロピル）を殺虫成分と共に配合したエアゾール剤は、共に、対照のエアゾール剤に比べてノックダウン効果が現れるのが極めて遅く、家屋害虫であるイエシロアリに対しては、効力増強効果を発揮できなかった。このことは、従来提案されている技術からみて驚くべきことであり、炭素数６〜１０の脂肪酸と炭素数２〜８のアルコールとのエステルを殺虫成分と共に配合することによる効力増強効果は、衛生害虫に対する特異的な効果であると言える。

As is apparent from the results shown in Table 6, an aerosol agent (containing isopropyl caprate) formulated according to the present invention and an esterified product of lauric acid (isopropyl laurate), which is a fatty acid having 12 carbon atoms, were formulated together with an insecticidal component. Both of the aerosols exhibited a very slow knockdown effect as compared with the control aerosol, and were unable to exert the effect of enhancing the efficacy against the house insect pest. This is surprising in view of the conventionally proposed technology, and the effect of enhancing the efficacy by blending an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms with an insecticidal component is hygienic. It can be said that this is a specific effect against pests.

Test Example 6
As the test insect A, an adult cat flea is used, and each of the aerosol agents (using LPG as a propellant) is sprayed at a distance of L = 30 cm and a total spray amount of 0.9 g (spray for about 0.5 seconds). After spraying, the number of knockdown insects was counted over time, and KT ₅₀ (seconds) was determined by Bliss's Probit method. Table 7 shows the obtained knockdown effect. In addition, the lethal effect on the adult cat flea at that time is also shown in Table 7.

前記表７に示す結果から明らかなように、本発明に従って処方されたエアゾール剤（カプリン酸イソプロピル含有）は、ネコノミに対しても、対照のエアゾール剤に比べて速やかにノックダウン効果が現れ、また致死効果も高かったが、炭素数１２の脂肪酸であるラウリン酸のエステル化物（ラウリン酸イソプロピル）を殺虫成分と共に配合した場合、対照のエアゾール剤に比べてノックダウン効果が現れるのが極めて遅く、また致死効果も劣っていた。

As is apparent from the results shown in Table 7, the aerosol formulation (containing isopropyl caprate) formulated according to the present invention has a knockdown effect on cat fleas more quickly than the control aerosol formulation, and Although the lethal effect was high, when the esterified product of lauric acid (isopropyl laurate), which is a fatty acid having 12 carbon atoms, was combined with an insecticidal component, the knockdown effect appeared very slowly compared to the control aerosol agent, and The lethal effect was also inferior.

It is a schematic block diagram of the apparatus used in order to evaluate the pest control effect in each test example by the direct spray method.

Explanation of symbols

1: Glass ring 2: Net 3: Stand 4: Stand 5: Glass cylinder A: Test insect L: Spray distance

Claims (3)

(A) pyrethroid insecticide,
(B) an ester of a fatty acid having 6 to 10 carbon atoms and an alcohol having 2 to 8 carbon atoms,
A sanitary pest control agent comprising the component (A) and the component (B).   The sanitary pest control agent according to claim 1, wherein the content of the component (B) with respect to the total solvent is 5 to 100 mass%. The sanitary pest control agent according to claim 1 or 2, further comprising an aerosol containing a propellant.

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