JP2022062129A - Insect repellent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide consumer care products that can effectively repel insect species and acarids without repelling birds and are useful for repellent purposes including protecting wooden bird feeders from unwanted insects.

SOLUTION: This invention relates to pest repellent compositions comprising a fatty acid and an anthranilate ester, to a method of repelling pests employing such composition, and to products formulated from such compositions.

SELECTED DRAWING: None

COPYRIGHT: (C)2022,JPO&INPIT

Description

(Mutual reference of related applications)
This application claims the priority benefit of US Provisional Patent Application No. 62/301364 filed February 29, 2016. The entire contents of this provisional patent application are incorporated herein by reference.

(Technical field)
In one aspect, the invention relates to a pest repellent composition comprising a fatty acid and an anthranilic acid ester. In another aspect, the present invention relates to a pest repellent method using the composition.

Insects and tick pests can cause serious damage to crops and horticultural plants. In addition, insects and pests may carry pathogens that cause disease in both humans and animals. For example, mosquitoes may carry the virus that causes encephalitis, and mites may carry the bacteria that cause Lyme disease. One method of repelling such pests involves applying chemicals that repel such pests from a given environment. For example, chemicals such as N, N-diethyl-m-toluamide (also known as DEET) are used as repellents to protect individuals from mosquitoes, mites and other similar pests. Other chemicals that affect the behavior of insects are used to attract or repel insects from the environment in a predetermined manner in order to increase the effectiveness of the pesticide, which is to use the pesticide more effectively. Either by attracting insects to areas where they can grow, or by repelling insects from areas where pesticides are ineffective.

One of the compounds used to influence the behavior of insects to move them to different environments is methyl anthranilate. Thus, all of Patent Document 1 (Askham et al.), Patent Document 2 (Dunham et al.) And Patent Document 3 (Dunham et al.) Disclose the use of methyl anthranilate in the form of commercial product BIRDSHIELD®. It attracts insects to move from one environment to another (see, eg, Patent Document 2, Columns 9, lines 26-33).

Anthranilic acid esters such as methyl anthranilate have long been known to be useful as bird repellents. For example, Patent Document 4 (Kara) discloses the use of such compounds to prevent both domestic and wild birds from eating seeds, fruits, grains, fruits and the like. In addition, such compounds have been discovered as insect attractants. For example, Patent Document 5 (Askham) states that "insects are easily attracted to dimethyl anthranilate and methyl anthranilate. Relatively insect-free crops are treated with either material and then immediately again. Flocked. ”(Column 3, rows 20-23). This finding is supported by the disclosures of Patent Document 1 (Askham et al.), Patent Document 2 (Dunham et al.) And Patent Document 3 (Dunham et al.), In Table 1 of such publications, the adhesive traps containing methyl anthranilate. It was soon shown to be covered with hundreds of insects. The only exception present in these patents is the housefly (Musca domesticae), which is repelled by the use of methyl anthranilate.

All of Patent Document 1, Patent Document 2 and Patent Document 3 describe BIRDSHIELD (registered trademark) which is a mixture of methyl anthranilate and a fatty acid, but the label of such a product is a claim of Patent Document 5. It is said to indicate that it is covered by. This patent relates to a bird repellent composition comprising an anionic surfactant consisting of an alkyl metal salt of a fatty acid rather than a fatty acid in the form of an acid. According to this publication, the addition of such fatty acid salts results in the formation of micelles of such anthranilic acid compounds, allowing for a more uniform distribution of such compounds on the treated surface and a bird repellent. To enhance the effect as.

Given that compounds containing anthranilic acid esters and fatty acid salts attract most insects and repel birds, compositions containing anthranilic acid esters and fatty acids in the form of acids are more common without repelling birds. It is completely unexpected that it is useful for a variety of extermination purposes, including repelling insects as effectively as mites and protecting bird feeders from unwanted insects.

In addition, many substances are used to change the appearance of a subject, protect the subject from the environment, or cause biological changes in the skin or other tissues for therapeutic, prophylactic, or cosmetic purposes. It is applied topically to the skin or mucous membranes of animals (hereinafter "skin"). These substances are commonly referred to as "consumer care products" and include topically applied substances such as cosmetics, over-the-counter and prescription topical medications, and various other products such as soaps and detergents. ..

Consumer care products come in a variety of forms, including solids, liquids, suspensions, semi-solids (such as creams, gels, pastes or "sticks"), powders, or finely dispersed liquids such as splashes or mists. Examples of consumer care products commonly classified as "cosmetics" are skin care products such as creams, lotions, moisturizers, and "therapeutic cosmetics" such as scrubbing agents and / or skin cell regenerating agents; perfumes and colognes. Fragrances, deodorants such as: creams, "bracers" and shaving-related products such as after-shave, depilatory and other depilatory products; skin cleansers, toners and astringents; wet tissues and wash lotions; tanning lotions Bath cosmetics such as oils; Eye care products such as eye drops and makeup removers; Foot care products such as powders and sprays; Skin colorants such as foundations, browns, rouge, eye shadows and liners, lip colors and mascara and Makeup products; Lip creams and sticks; Hair care and treatment products such as shampoos, conditioners, colorants, dyes, bleaching agents, orthodontic agents and permanent wave products; Baby such as baby lotions, oils, shampoos, powders and wet tissues Supplies; women's hygiene products such as deodorants and lotions; skin or facial skin used by dermatologists or beauticians; skin care products such as others.

Examples of consumer care products commonly classified as topical agents are many and diverse, including antiperspirants, insect repellents, sunscreens and sun remedies, anti-acne drugs, antibiotics, topical respiratory drugs, eye drops. And eye medicines such as physiological saline, therapeutic retinoids, antifungal agents, external painkillers such as capsaicin products, local contraceptives, local drug delivery systems, suppositories, enema, gastrointestinal drugs such as hemorrhoids, vaginal treatments Includes genital agents, oral treatments such as tablets, and commercial and / or prescription products such as many other products with therapeutic or other effects. Other consumer care products include hand, face and body soaps and detergents, and other forms of skin cleansers, as well as solvents, propellants, brighteners, lubricants, adhesives, waxes and other household cleaners. Containing, used topically or locally exposed to the body during normal use.

Applicants can help repel insects, including anthranilic acid esters and fatty acid salts, which can effectively repel insects and mites without repelling birds and protect bird feeders from unwanted insects. Recognizing the need to develop consumer care products.

U.S. Pat. No. 6,958,146 U.S. Pat. No. 7,867,479 U.S. Pat. No. 8092790 U.S. Pat. No. 2,967,128 U.S. Pat. No. 5,296,226

In one aspect, the invention relates to a composition comprising (a) anthranilic acid ester; and (b) an amount of composition that repels insects or mites, including fatty acids.

In another aspect, the invention relates to methods of repelling insects and / or tick pests using such compositions.

In another embodiment, the invention relates to a consumer care product for repelling insects and / or tick pests.

In another aspect, the present invention is the first active ingredient selected from the group consisting of (a) dimethyl anthranilate, methyl anthraniate, ethyl anthraniate, phenylethyl anthranilate and menthyl anthranilate; (b) fatty acids; A composition comprising an insect or tick repellent, comprising (c) at least one additional active ingredient, optionally and (c) a pharmaceutically suitable topical carrier, said first active ingredient. The ratio of the fatty acid to the fatty acid is about 6: 1; 5: 1; 4: 1; or 3: 1. In a more preferred embodiment, this ratio is from about 5: 1 to 4: 1.

In another aspect, the invention is a composition comprising the insect or mite repellents described herein, wherein the fatty acids are oleic acid, ricinoleic acid, linoleic palmitic acid, stearic acid and any of them. Selected from the group consisting of mixtures.

In another aspect, the invention is a composition comprising the insect or mite repellent described herein, wherein the fatty acid is oleic acid.

In another aspect, the invention is a composition comprising the insect or tick repellents described herein, wherein the active ingredient is dimethyl anthranilate, methyl anthranilate, ethyl anthranilate, phenylethyl anthranilate. And anthranilic acid ester selected from the group consisting of anthranilate menthyl. In certain embodiments, the anthranilic acid ester is methyl anthranilate.

In another aspect, the invention is a composition comprising the insect or tick repellents described herein, further comprising a surfactant, an emulsifier, a pH regulator, a thickener, an antioxidant, a storage. Agents, skin preparations, emollients, moisturizers, silicone parts, anti-inflammatory agents, sunscreens, local anesthetics, vitamins, antipruritics, antibiotics, antifungal agents, preservatives, vasoconstrictors and theirs Includes additional compounds selected from the group consisting of any mixture.

In certain embodiments, the emulsifier is a polysaccharide ether, polyglycoside, fatty acid, fatty alcohol, amine oxide, water-soluble cellulose, alkyl sulfonate, alkyl ethoxylated phenol, alkanolamide, betaine, amphoteric surfactant, carboxylated. It is selected from the group consisting of alcohols, carboxylic acids, ethoxylated C ₁₂ -C ₁₅ alcohols, polysorbates, behentrimonium metosulfates, isopropylmillistate and ethoxylated castor oil or any mixture thereof.

In certain embodiments, the thickener is selected from the group consisting of carboxylic acid polymers, acrylic acid crosslinked with allyl ether of sucrose, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, gums and mixtures thereof.

In certain embodiments, the polysaccharides are cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium sulfate. , Chitosan and mixtures thereof.

In certain embodiments, the gums are carrageenan calcium, carrageenan, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectrite, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, etc. It is selected from the group consisting of carrageenan potassium, screrotium gum, carrageenan sodium, tragacanto gum, kitasan gum and any mixture thereof.

In another aspect, the invention is a composition comprising the insect or mite repellents described herein, wherein the pharmaceutically suitable topical carrier is water, glycerin, lecithin, fatty acid or any of them. Including combinations of.

In certain embodiments, the fatty acid is selected from the group consisting of oleic acid, ricinoleic acid, linoleic acid, palmitic acid, stearic acid or any mixture thereof.

In certain embodiments, the sunscreen is PABA, PABA ester, butyl PABA, ethyl PABA, ethyldihydroxypropyl PABA, benzophenone, avobenzon, silicate ester, salicyl acid ester, anthranyl acid ester, ethyl urocanate, homosalate, It is selected from the group consisting of dibenzoylmethane, octocrylene, methylbenzylenecanpher, kaolin, talc, vaseline, and metal oxides or any mixture thereof.

Another aspect of the invention repels insects from a subject, comprising topically administering to a subject in need of repelling the insect a composition comprising the insect or tick repellent described herein. Including methods.

In certain embodiments, the subject is a mammal. In another embodiment, the subject is a human. In another embodiment, the subject is a domestic animal.

In certain embodiments, the composition is applied directly to the skin, the garment of interest and / or the garment.

In another aspect of the invention, (a) a first active ingredient selected from the group consisting of dimethyl anthranilate, methyl anthraniate, ethyl anthraniate, phenylethyl anthraniate and menthyl anthranilate; (c). Includes consumer care products prepared by steps comprising mixing at least one additional active ingredient as required, (b) adding a pharmaceutically suitable topical carrier to the mixture; said first. The ratio of 1 active ingredient to the fatty acid is about 6: 1; 5: 1; 4: 1; or 3: 1. In a more preferred embodiment, the ratio of the first active ingredient to the fatty acid is about 5: 1 or 4: 1.

In certain embodiments, the fatty acids in the consumer care products described above are selected from the group consisting of oleic acid, ricinoleic acid, linoleic acid, palmitic acid, stearic acid and any mixture thereof. In other embodiments, the fatty acid is oleic acid.

In certain embodiments, the active ingredient in the consumer care product described above is an anthranilic acid ester selected from the group consisting of dimethyl anthranilate, methyl anthranilate, ethyl anthranilate, phenylethyl anthranilate and menthyl anthranilate. be. In certain embodiments, the anthranilic acid ester is methyl anthranilate. In certain embodiments, the anthranilic acid ester is methyl anthranilate.

In certain embodiments, the consumer care product further comprises a surfactant, an emulsifier, a pH regulator, a thickener, an antioxidant, a preservative, a skin preservative, a emollient, a moisturizer, a silicone moiety. Includes additional compounds selected from the group consisting of anti-inflammatory agents, sunscreens, topical anesthetics, vitamins, antipruritic agents, antibiotics, antifungal agents, preservatives, vasoconstrictors and any mixtures thereof.

In other embodiments, the emulsifier is a polysaccharide ether, polyglycoside, fatty acid, fatty alcohol, amine oxide, water-soluble cellulose, alkyl sulfonate, alkyl ethoxylated phenol, alkanolamide, betaine, amphoteric surfactant, carboxylated. It is selected from the group consisting of alcohols, carboxylic acids, ethoxylated C ₁₂ -C ₁₅ alcohols, polysorbate, behentrimonium metosulfate, isopropylmillistate and ethoxylated castor oil or any mixture thereof.

In certain embodiments, the thickener is selected from the group consisting of carboxylic acid polymers, acrylic acid crosslinked with allyl ether of sucrose, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, gums and mixtures thereof.

In certain embodiments, the polysaccharides are cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium sulfate. , Chitosan and mixtures thereof.

In certain embodiments, the gums in said consumer care products are carrageenan calcium, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectrite, hydroxypropyl guar, karaya gum, kelp, locust. It is selected from the group consisting of bean gum, natto gum, carrageen potassium, screrotium gum, carrageenan sodium, tragacanto gum, kitasan gum and any mixture thereof.

In certain embodiments, the pharmaceutically suitable topical carrier comprises water, glycerin, lecithin, fatty acids or any combination thereof.

In other embodiments of the consumer care product, the fatty acid is selected from the group consisting of oleic acid, ricinoleic acid, linoleic acid, palmitic acid, stearic acid and any mixture thereof.

In certain embodiments of the consumer care product, the sunscreen is PABA, PABA ester, butyl PABA, ethyl PABA, ethyldihydroxypropyl PABA, benzophenone, avobenzon, silicate ester, salicyl acid ester, anthranyl acid ester, It is selected from the group consisting of ethyl urocanate, homosalate, dibenzoylmethane, octocrylene, methylbenzilidencanpher, kaolin, talc, vaseline, and metal oxides or any mixture thereof.

Another aspect of the invention includes a wet tissue product comprising a woven or non-woven or cellulosic substrate and a composition comprising the insect or mite repellent described herein.

Another aspect of the invention comprises a method of killing an insect or pest, comprising supplying a composition comprising the insect or mite repellent described herein, wherein the composition is applied to the insect or pest. By doing so, the insects or pests are killed and the applied amount is sufficient for the insects or pests to kill.

In another aspect of the invention, a first active ingredient selected from the group consisting of (a) dimethyl anthranilate, methyl anthranilate, ethyl anthranilate, phenylethyl anthranilate and menthyl anthranilate; (b) fatty acids; ( c) including a method of repelling insects or mites from clothing or bedding, comprising placing at least one additional active ingredient as required; and (d) a composition comprising a carrier in a set position. When an insect comes into contact with the composition, or steam from the composition, the insect is repelled: the composition is applied topically to clothing or bedding articles; or a detergent or cloth containing the composition. It is arranged by washing the garment or bedding article with fabric softener or both, or by drying the garment or bedding article with a cloth softener containing its composition.

In another aspect of the invention, a first active ingredient selected from the group consisting of (a) dimethyl anthranilate, methyl anthranilate, ethyl anthranilate, phenylethyl anthranilate and menthyl anthranilate; (b) fatty acids; c) A method of repelling insects or ticks comprising placing an insect repellent composition comprising at least one additional active ingredient as required; and (d) a carrier, wherein the insect or tick is said to have such composition. It is repelled when it comes in contact with an object or steam from the composition.

In a further embodiment of this method, the ratio of the first active ingredient to the early fatty acid is 5: 1 or 4: 1.

In a further embodiment of this method, the composition is to apply the composition topically to an article of human clothing; or to apply the composition topically to human skin or hair; Topically applying the composition to the skin or hair of an animal; or washing an article of human clothing with a detergent or cloth softener containing the composition; or the composition. Drying articles of human clothing with a cloth softener containing; applying the composition to bedding, bedboards, bed slats, mattresses, box springs, furniture, carpets, baseboards or floorings or combinations thereof; Or spraying the composition onto the surface of bedding, bedboards, bed slats, mattresses, box springs, furniture or carpets; or injecting the composition into mattresses, box springs, furniture or carpets or combinations thereof. Or, in the vicinity of the bedboard, bed slats, mattress, box spring, furniture or carpet, so that the steam from the composition comes into contact with the surface of the bed board, bed slats, mattress, box spring, furniture or carpet. Placed by placing an absorbent substrate or gel containing the composition; by injecting the composition into a wall space.

In another aspect of the invention, the composition comprises the insect or mite repellent described herein, said composition being formulated as a personal care or cosmetic composition.

In certain embodiments, the personal care or cosmetic composition is formulated as a product selected from insect repellents, skin care products, hair care products or cleansing products.

In other embodiments, the composition comprising the insect or mite repellent described herein is formulated as a household composition.

In certain embodiments, the household composition is a liquid, gel or solid form of air deodorant / cleaning agent composition, general purpose cleaner composition, general purpose disinfectant composition, deodorant spray and powder, dishwashing detergent, Cloth sizing composition, cloth softening composition, cloth electrostatic control composition, hard surface cleaning composition, hard surface cleaning agent, hard surface disinfecting composition, linen and bedding spray composition, agricultural pesticide composition, polishing Compositions, laundry detergents, carpet and interior shampoo compositions, cleaners and deodorants, cleaning and disinfecting compositions for tiles, toilets and bathtubs, waxes and cleaning compositions for treating wooden floors or furniture, And formulated as a product selected from automotive waxes and cleaning compositions.

Another aspect of the invention is the repellent of insects or mites described herein, which is a fabric softening composition selected from liquid fabric softeners, fabric softeners, fabric softening sheets and fabric softening gels. Contains a composition comprising an agent.

Another aspect of the invention includes a cloth-treated sheet containing a composition comprising the insect or mite repellent described herein.

In another aspect of the invention, a first active ingredient selected from the group consisting of (a) dimethyl anthranilate, methyl anthranilate, ethyl anthranilate, phenylethyl anthranilate and menthyl anthranilate; (b) fatty acids; c) includes at least one additional active ingredient as required; and (c) a method of treating a structure infested with insects or ticks, comprising placing a composition comprising a carrier. In a preferred embodiment, the ratio of the first active ingredient to the fatty acid is about 5: 1 or 4: 1.

In one aspect, the invention relates to a composition comprising (a) anthranilic acid ester; and (b) an amount of composition that repels insects and / or mites, including fatty acids. In this application, the terms "composition" and "formulation" are interchangeable.

In another aspect, the invention is the first active ingredient selected from the group consisting of (a) dimethyl anthranilate, methyl anthranilate, ethyl anthranilate, phenylethyl anthranilate and menthyl anthranilate; (b) fatty acids; A composition comprising an insect or tick repellent, comprising (c) at least one additional active ingredient, optionally and (c) a pharmaceutically suitable topical carrier, the first active ingredient pair. The fatty acid ratio is about 6: 1; 5: 1; 4: 1; or 3: 1.

Anthranilic acid esters that can be used include the compounds described in US Pat. No. 2,967,128, which is incorporated herein by reference, dimethyl anthranilate, methyl anthranilate, anthranilic acid. Includes ethyl, phenylethyl anthranilate and menthyl anthranilate. More preferred anthranilic acid esters are dimethyl anthranilate and methyl anthranilate, and particularly preferably methyl anthranilate.

The fatty acid that can be used as the component (b) is a saturated and unsaturated fatty acid containing 8 to 24 carbon atoms, preferably a fatty acid containing 13 to 21 carbon atoms. Examples of fatty acids that can be used are oleic acid, ricinoleic acid, linoleic acid, palmitic acid and stearic acid, with particular preference being oleic acid.

Generally, the weight ratio of anthranilic acid ester to fatty acid used in the compositions herein is in the range of 20: 1 to 1:10. In certain embodiments, such ratios range from 5: 1 to 1:10. In other embodiments, such ratios are 5: 1 to 1: 5. In yet another embodiment, the weight ratio of anthranilic acid ester to fatty acid is 5: 1 or 4: 1.

The compositions of the present invention may further contain additional additives traditionally used in agricultural applications. However, it is a condition that such an additive in the composition is not present in a form that converts the fatty acid into a salt of a surfactant or another form. In some embodiments, this may be achieved by avoiding the addition of amines such as monoethanolamine, diethanolamine and triethanolamine.

Examples of additional ingredients that may be included in the compositions of the invention are antioxidants that help substantially sustain the desired action of fatty acids. Such antioxidants protect the chemical and physical integrity of fatty acids against reaction with oxygen alone or in the presence of light in air pollution. There are many suitable antioxidants consisting of commercial and specialty chemicals and their combinations, mixtures and unique compositions that are well known to those educated in the art.

In certain embodiments, one particular antioxidant is, but is not limited to, ascorbic acid palmitate, ascorbyl palmitate, butylated p-cresol, tert-butylhydroquinone, butylated hydroquinone monomethyl ether, butylhydroxyanisole, butyl. It is selected from the group containing hydroxytoluene, propyl gallate, tocopherol and combinations thereof. The amount of antioxidant is preferably 0.001 to 0.1% by weight of the total composition.

The composition may be used as it is, for example undiluted, but is preferably used in a diluted form. For example, the composition may be _a C1- _C4 alcohol (eg, methanol, ethanol, isopropyl alcohol, butanol), a ketone such as acetone, an ester such as ethyl acetate or isopropyl myristate, a purified petroleum distillation solution (eg, a purified petroleum distillation solution). Dissolved in a suitable solvent, such as Sunspray® 6E (Sunoco)) or other non-reactive solvent that evaporates, preferably in a short period of time, leaving an active mixture of fatty acids and anthranilic acid esters. Can be done. The composition is an emulsion formulated with auxiliary agents, surfactants, stabilizers and preservatives that are sprayed or applied, diluted with water, on surfaces such as mopping on the floor or wiping countertops. It can be prescribed as (EC). The extermination composition can also be formulated as an aerosol for application from a pressurized container. The extermination composition can be applied by any typical method, including, but not limited to, spraying, coating or immersing the covered object in the composition.

Another aspect of the invention is a composition comprising the insect or tick repellents described herein, further comprising a pharmaceutical activator, an insecticide, an agricultural insecticide, a fungal agent, a herbicide. Includes at least one additional active ingredient selected from fertilizers, pesticides and combinations thereof. Suitable additional active ingredients for the repellent of insects or mites described herein include:

Insecticides: A1) Carbamates consisting of aldicalb, aranicalve, benfuracarb, carbalyl, carbofuran, carbosulfane, methiocarb, mesomil, oxamil, pyrimicalve, propoxul and thiodicalve; A2) acephate, azinephosethyl, azinephosmethyl, chlorpyrifos, chlorpyrifos, Chlorpyrifos Methyl, Demeton-S-Methyl, Diadinone, Dichlorvos / DDVP, Diclotophos, Dimethate, Disulfoton, Ethion, Fenitrothion, Fention, Isoxathion, Malathion, Metamidaphos, Methidathios, Methidathios, Mebinphos, Monochrometophos, Oxy Cyclodiene organic chlorine compounds such as oxydemetonmethyl, parathion, parathionmethyl, fentoate, holate, hosalon, hosmet, phosphamide, pyrimiphosmethyl, quinalphos, terbuphos, tetrachlorpyrifos, triazophos and trichlorfon; A3) endosulfane. A4) fiproles consisting of ethiprol, fipronil, pyrafluprol and pyriprol; A5) neonicotinoids consisting of acetamiprid, chlorthianidin, dinotefuran, imidacloprid, nitempyram, thiacloprid and thiamethoxinoids; Spinosads such as; A7) Chlorpyrifos-channel activators derived from mectins consisting of abamectin, emamectin benzoate, ibermectin, lepimectin and milbemectin; A9) Selective parathionic feeding blockers such as pimetrodin, fronicamid and pyrifluquinazone; A10) tick growth inhibitors such as chlorpyrifosine, hexitiazox and ethoxazole; A11) such as diafenthiuron, fenbutatin oxide and propargit Mitochondrial ATP synthase inhibitor; oxidative phosphorylation decoupling agent such as chlorpyrifos; A12) nicotinic acetylcholine receptor channel such as benzultap, cartap hydrochloride, nereistoxin and thiosultap sodium Le Blocker; A13) Type 0 inhibitor of benzoylurea-derived chitin biosynthesis consisting of bistrifluron, diflubenzurone, fluphenoxron, hexaflumron, ruphenuron, novallon and teflubenzurone; A14) chitin raw such as buprofezin Synthetic Type 1 Inhibitors; A15) Moulting Disruptors such as Cypermethrin; A16) Exdison Receptor agonists such as methoxyphenodide, tebuphenodide, halophenozide and chromafenozide; A18) Mitrine complex electron transfer inhibitors such as pyridaben, tebufenpyrado, tolfenpyrado, flufenerim, cyenopyrafen, cypermethrin, hydramethylnone, acequinosyl or fluaclipyrim; A19) indoxacarb and metaflumizone. Dependent sodium channel blocker; A20) Inhibitors of lipid synthesis such as spirodiclofen, spiromesiphen and spirotetramato; A21) flubenzamide, phthalamide compound (R) -3-chlor-N1- {2-methyl- 4- [1,2,2,2-tetrafluoro-1- (trifluoromethyl) ethyl] phenyl} -N2- (1-methyl-2-methylsulfonylethyl) phthalamide, and (S) -3-chlor- N1- {2-methyl-4- [1,2,2,2-tetrafluoro-1- (trifluoromethyl) ethyl] phenyl} -N2- (1-methyl-2-methylsulfonylethyl) phthalamide, chlorane Rianodin receptor modulators derived from diamides consisting of traniliprol and cyantraniliplol; A22) Mechanism of action such as azadilactin, amidoflumeth, biphenazate, fluensulfone, piperonylbutoxide, pyridalyl, sulfoxaflor) Uncertain compounds; or A23) Acrinathrin, Areslin, Bifenthrin, Cypermethrin, Lambda-cypermethrin, Cypermethrin, Alpha-Cypermethrin, Beta-Cypermethrin, Zeta-Cypermethrin, Deltamethrin, Esphenvalerate, Etophenprox, Fenpropa Trin, Fen A sodium channel modulator derived from pyrethroids consisting of valerate, flucitrinate, tau-fluvalinate, permethrin, sirafluofen and tralomethrin.

Fungicide: B1) Viteltanol, bromconazole, cyproconazole, diphenoconazole, diniconazole, enylconazole, epoxyconazole, flukinconazole, fenbuconazole, flucirazole, flutriazole, hexaconazole, imi Benconazole, ipconazole, methconazole, microbutanyl, penconazole, propiconazole, prothioconazole, simeconazole, triazimehon, triazimenol, tebuconazole, tetraconazole, triticonazole, prochloraz, pefrazolazate p. Lumizole, siazofamide, benomil, carbendazim, thiabendazole, phenyldazole, etaboxam, etridiazole and himexazole, azaconazole, diniconazole-M, oxypoconazole (oxpoconazole), paclobutrazole, unicozol -Azole selected from the group consisting of chloro-phenyl) -2- ([1,2,4] triazole-1-yl) -cycloheptanol and imazalyl sulphate; B2) azoxystrobin, dimo Xistrobin, enestrobulin, fluoxastrobin, cresoximemethyl, metminostrobin, orisastrobin, picoxystrobin, pyracrostrobin, trifluoxystrobin, enestrobrin, methyl (2-chloro-5) [1- (3-Methylbenzyloxyimino) ethyl] benzyl) carbamate, methyl (2-chloro-5- [1- (6-methylpyridine-2-ylmethoxyimino) ethyl] benzyl) carbamate and methyl 2- ( Ortho- (2,5-dimethylphenyloxymethylene) -phenyl) -3-methoxyacrylate, 2- (2- (6- (3-chloro-2-methyl-phenoxy) -5-fluoro-pyrimidine-4-yloxy) ) -Phenyl) -2-Methoxyimino-N-methyl-acetamide, and 3-methoxy-2-(2-(N- (4-methoxy-phenyl) -cyclopropanecarboxyimideyl sulfanylmethyl) -phenyl) -acrylic Strovirlin selected from the group consisting of acid methyl esters; B3 ) Carboxin, Benalaxil, Benalaxil-M, Fenhexamide, Frutranil, Flametopil, Mepronil, Metalaxil, Mephenoxam, offrace, Oxadixil, Oxycarboxyne, Penthiopyrado, Isopyrazam, Thifluzamide, Thiazinyl, 3,4-dichloro- N- (2-cyanophenyl) isothiazole-5-carboxamide, dimethmorph, flumorph, flumethover, fluoripicolide (picobenzamide), zoxamide, carpropamide, diclosimet, mandipropamide, N- (2- (4- [3- (4- [3- ( 4-Chlorophenyl) propa-2-inyloxy] -3-methoxyphenyl) ethyl) -2-methanesulfonyl-amino-3-methylbutylamide, N- (2- (4- [3- (4-chloro-phenyl)) Propa-2-inyloxy] -3-methoxyphenyl) ethyl) -2-ethanesulfonylamino-3-methylbutylamide, methyl-3- (4-chlorophenyl) -3- (2-isopropoxycarbonyl-amino-3-) Methyl-butyrylamino) propionate, N- (4'-bromobiphenyl-2-yl) -4-difluoromethyl-methylthiazole--carboxamide, N- (4'-trifluoromethyl-biphenyl-2-yl) -4- Difluoromethyl-2-methylthiazole-5-carboxamide, N- (4'-chloro-3'-fluorobiphenyl-2-yl) -4-difluoromethyl-2-methyl-thiazole-5-carboxamide, N- (3) , 4'-Dichloro-4-fluorobiphenyl-2-yl) -3-difluoromethyl-1-methylpyrazole-4-carboxamide, N- (3', 4'-dichloro-5-fluorobiphenyl-2-yl) -3-Difluoromethyl-1-methylpyrazole-4-carboxamide, N- (2-cyano-phenyl) -3,4-dichloroisothiazole-5-carboxamide, 2-amino-4-methyl-thiazole-5-carboxy Anilide, 2-chloro-N- (1,1,3-trimethyl-indan-4-yl) -nicotinamide, N- (2- (1,3-dimethylbutyl) -phenyl) -1,3-dimethyl- 5-Fluoro-1H-pyrazole-4-carboxamide, N- (4'-chloro-3', 5-difluoro-biphenyl-2-yl) -3-difluoromethyl-1-methyl-1H-pyrazo Lu-4-carboxamide, N- (4'-chloro-3', 5-difluoro-biphenyl-2-yl) -3-trifluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, N- (3) ', 4'-Dichloro-5-fluoro-biphenyl-2-yl) -3-trifluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, N- (3', 5-difluoro-4'-methyl -Biphenyl-2-yl) -3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, N- (3', 5-difluoro-4'-methyl-biphenyl-2-yl) -3-tri Fluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, N- (cis-2-bicyclopropyl-2-yl-phenyl) -3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, N -(Trans-2-bicyclopropyl-2-yl-phenyl) -3-difluoro-methyl-1-methyl-1H-pyrazole-4-carboxamide, fluorium, N- (3-ethyl-3,5-5-trimethyl) -Cyclohexyl) -3-formylamino-2-hydroxy-benzamide, oxytetracycline, silthiofam, N- (6-methoxy-pyridin-3-yl) cyclopropanecarboxamide, 2-iodo-N-phenyl-benzamide, N- ( 2-Bicyclo-propyl-2-yl-phenyl) -3-difluoromethyl-1-methylpyrazole-4-ylcarboxamide, N- (3', 4', 5'-trifluorobiphenyl-2-yl) -1 , 3-Dimethylpyrazole-4-ylcarboxamide, N- (3', 4', 5'-trifluorobiphenyl-2-yl) -1,3-dimethyl-5-fluoropyrazole-4-yl-carboxamide, N -(3', 4', 5'-trifluorobiphenyl-2-yl) -5-chloro-1,3-dimethyl-pyrazole-4-ylcarboxamide, N- (3', 4', 5'-tri Fluorobiphenyl-2-yl) -3-fluoromethyl-1-methylpyrazole-4-ylcarboxamide, N- (3', 4', 5'-trifluorobiphenyl-2-yl) -3- (chlorofluoromethyl) ) -1-Methylpyrazole-4-ylcarboxamide, N- (3', 4', 5'-trifluorobiphenyl-2-yl) -3-difluoromethyl-1-methylpyrazole-4-ylcarboxamide, N- (( 3', 4', 5'-trifluorobiphenyl-2-yl) -3-difluoromethyl-5-fluoro-1-methylpyrazole-4-ylcarboxamide, N- (3', 4', 5'-tri Fluorobiphenyl-2-yl) -5-chloro-3-difluoromethyl-1-methylpyrazole-4-ylcarboxamide, N- (3', 4', 5'-trifluorobiphenyl-2-yl) -3- (Chlorodifluoromethyl) -1-methylpyrazole-4-ylcarboxamide, N- (3', 4', 5'-trifluorobiphenyl-2-yl) -1-methyl-3-trifluoromethylpyrazole-4- Ilcarboxamide, N- (3', 4', 5'-trifluorobiphenyl-2-yl) -5-fluoro-1-methyl-3-trifluoromethylpyrazole-4-ylcarboxamide, N- (3', 4', 5'-trifluorobiphenyl-2-yl) -5-chloro-1-methyl-3-trifluoromethylpyrazole-4-ylcarboxamide, N- (2', 4', 5'-trifluorobiphenyl -2-yl) -1,3-dimethylpyrazole-4-ylcarboxamide, N- (2', 4', 5'-trifluorobiphenyl-2-yl) -1,3-dimethyl-5-fluoropyrazole- 4-Ilcarboxamide, N- (2', 4', 5'-trifluorobiphenyl-2-yl) -5-chloro-1,3-dimethylpyrazole-4-ylcarboxamide, N- (2', 4' , 5'-Trifluorobiphenyl-2-yl) -3-fluoromethyl-1-methylpyrazole-4-ylcarboxamide, N- (2', 4', 5'-trifluorobiphenyl-2-yl) -3 -(Chlorofluoromethyl) -1-methylpyrazole-4-ylcarboxamide, N- (2', 4', 5'-trifluorobiphenyl-2-yl) -3-difluoromethyl-1-methylpyrazole-4- Ilcarboxamide, N- (2', 4', 5'-trifluorobiphenyl-2-yl) -3-difluoromethyl-5-fluoro-1-methylpyrazole-4-ylcarboxamide, N- (2', 4) ', 5'-Trifluorobiphenyl-2-yl) -5-chloro-3-difluoromethyl-1-methylpyrazole-4-ylcarboxamide, N- (2', 4', 5'-trifluorobiphenyl-2 -Il) -3- (Chlorodifluoromethyl) -1-methylpyrazole-4-ylcarboxamide , N- (2', 4', 5'-trifluorobiphenyl-2-yl) -1-methyl-3-trifluoromethylpyrazole-4-ylcarboxamide, N- (2', 4', 5'- Trifluorobiphenyl-2-yl) -5-fluoro-1-methyl-3-trifluoromethylpyrazole-4-ylcarboxamide, N- (2', 4', 5'-trifluorobiphenyl-2-yl)- 5-Chloro-1-methyl-3-trifluoromethylpyrazole-4-ylcarboxamide, N- (3', 4'-dichloro-3-fluorobiphenyl-2-yl) -1-methyl-3-trifluoromethyl -1H-pyrazole-4-carboxamide, N- (3', 4'-dichloro-3-fluorobiphenyl-2-yl) -1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide, N- ( 3', 4'-Difluoro-3-fluorobiphenyl-2-yl) -1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N- (3', 4'-difluoro-3-fluoro) Biphenyl-2-yl) -1-methyl-S-difluoromethyl-1H-pyrazole-4-carboxamide, N- (3'-chloro-4'-fluoro-3-fluorobiphenyl-2-yl) -1-methyl -3-Difluoromethyl-1H-pyrazole-4-carboxamide, N- (3', 4'-dichloro-4-fluorobiphenyl-2-yl) -1-methyl-3-trifluoromethyl-1H-pyrazole-4 -Carboxamide, N- (3', 4'-difluoro-4-fluorobiphenyl-2-yl) -1-methyl-S-trifluoromethyl-1H-pyrazole-4-carboxamide, N- (3', 4' -Dichloro-4-fluorobiphenyl-2-yl) -1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide, N- (3', 4'-difluoro-4-fluorobiphenyl-2-yl) -1-Methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide, N- (3'-chloro-4'-fluoro-4-fluorobiphenyl-2-yl) -1-methyl-S-difluoromethyl- 1H-pyrazole-4-carboxamide, N- (3', 4'-dichloro-5-fluorobiphenyl-2-yl) -1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N- ( 3', 4'-difluoro-5-fluorobiphenyl -2-Il) -1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N- (3', 4'-dichloro-5-fluorobiphenyl-2-yl) -1-methyl-S -Difluoromethyl-1H-pyrazole-4-carboxamide, N- (3', 4-
Difluoro-5-fluorobiphenyl-2-yl) -1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide, N- (3', 4'-dichloro-5-fluorobiphenyl-2-yl)- 1,3-dimethyl-1H-pyrazole-4-carboxamide, N- (3'-chloro-4'-fluoro-5-fluorobiphenyl-2-yl) -1-methyl-3-difluoromethyl-1H-pyrazole- 4-Carboxamide, N- (4-Fluoro-4-fluorobiphenyl-2-yl) -1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N- (4'-fluoro-5-fluoro) Biphenyl-2-yl) -1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N- (4'-chloro-5-fluorobiphenyl-2-yl) -1-methyl-3-tri Fluoromethyl-1H-pyrazole-4-carboxamide, N- (4'-methyl-5-fluorobiphenyl-2-yl) -1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N- ( 4'-Fluoro-5-fluorobiphenyl-2-yl) -1,3-dimethyl-1H-pyrazole-4-carboxamide, N- (4'-chloro-5-fluorobiphenyl-2-yl) -1,3 -Dimethyl-1H-pyrazole-4-carboxamide, N- (4'-methyl-5-fluorobiphenyl-2-yl) -1,3-dimethyl-1H-pyrazole-4-carboxamide, N- (4'-fluoro) -6-Fluorobiphenyl-2-yl) -1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, N- (4'-chloro-6-fluorobiphenyl-2-yl) -1-methyl -3-Trifluoromethyl-1H-pyrazole-4-carboxamide, N- [2- (1,1,2,3,3,3-hexafluoropropoxy) -phenyl] -3-difluoromethyl-1-methyl- 1H-pyrazole-4-carboxamide, N- [4'-(trifluoromethylthio) -biphenyl-2-yl] -3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, and N- [4' -(Trifluoromethylthio) -biphenyl-2-yl] -1-methyl-3-trifluoromethyl-l-methyl-1H-pyrazole-4-carboxamide selected from the group consisting of carboxamide; B4) fluazina Pyridine, bupylmate, cyprodinyl, phenalimol, ferimzone, mepanipyrim, nuarimol, pyrimethanyl, trifolin, phenpicronyl, fludioxonyl, aldimorph, dodemorph, phenpropimorph, tridemorph, phenpropidine, iprodion, procidone. Famoxadone, fenamiden, octylinone, compound-azole, 5-chloro-7- (4-methylpyperidine-1-yl) -6- (2,4,6-trifluorophenyl) [1, 2,4] Triazolo [1,5-a] pyrimidin, anilazine, dichromedin, pyrokyron, proquinazid, tricyclazole, 2-butoxy-6-iodo-3-propylchromen-4-one, asibenzoral-S -Methyl, captahole, captan, dazomet, holpet, phenoxanyl, quinoxyphen, N, N-dimethyl-3- (3-bromo-6-fluoro-2-methylindol-1-sulfonyl)-[1,2,4] triazole -1-sulfonamide, 5-ethyl-6-octyl [1,2,4] triazolo [1,5-a] pyrimidin-2,7-diamine, 2,3,5,6-tetrachloro-4-methane Sulfonyl-Pyridine, 3,4,5-trichloropyridin-2,6-dicarbonitrile, N- (1- (5-bromo-3-chloro-pyridine-2-yl) -ethyl) -2,4-dichloro Nicotinamide, N-((5-bromo-3-chloropyridin-2-yl) -methyl) -2,4-dichloro-nicotinamide, diflumethrim, nitrapyrin, dodemorphacetate, fluoroimide, blastsai Heterocyclic compounds selected from the group consisting of gin-S, quinomethionate, debacalve, difenzoquat, diphenzoquat-methylsulfat, oxophosphate and piperulin; B5) mancozeb, maneb, metam, meta. Sulfocarb, methylphocarb, methylam, fervum, propineb, tiram, geneb, dilam, dietophencarb, iprovaricarb, benchavaricarb, propamocarb, propamocarb hydrochloride, 4-fluorophenyl-N- (1- (1- (4- (4- (4- (4-) Selected from the group consisting of cyanophenyl) -ethanesulfonyl) buto-2-yl) carbamate, methyl-3- (4-chloro-phenyl) -3- (2-isoproxycarbonylamino-3-methyl-butylylamino) propanoate. Carbamate; or B6) guanidine, dodin, dodin free base, iminoctadine, guazatin, antibiotics such as casgamycin, streptomycin, polyoxin, varydamycin A, nitrophenyl derivative: vinapacryl, dinocup, dinobutone, sulfur-containing heterocyclic compound: dithianone. , Isoprothiolane, Organic metal compound: Fentin salt, Organic phosphorus compound: Edifenphos, Iprobenphos, Josetil, Josetyl-aluminum, Hypophosphate and its salts, Pyrazophos, Torquelophosmethyl, Organic chlorine compound: Diclofluanide, Flusulfamide, Hexachlorobenzene, Phthalide , Pencyclon, quintozen, thiophanatemethyl, trillfluanide, etc .: siflufenamide, simoxanyl, dimethyrimol, etilimol, flaluxil, metrafenone and spiroxamine, guazatin acetate, iminoctadine-triacetate, iminoctadinetris (albesilate, albesilate) Dichlorophen, pentachlorophenol and its salts, N- (4-chloro-2-nitro-phenyl) -N-ethyl-4-methyl-benzenesulfonamide, dichlorane, nitrotalisopropyl, technazen, biphenyl, bronopole, diphenylamine, Mildiomycin, oxincopper, prohexadione calcium, N- (cyclopropylmethoxyimino- (6-difluoromethoxy-2,3-difluorophenyl) -methyl) -2-phenylacetamide, N'-(4) -(4-Chloro-3-trifluoromethyl-phenoxy) -2,5-dimethyl-phenyl) -N-ethyl-N-methylformamidine, N'-(4- (4-fluoro-3-trifluoromethyl)-(4-fluoro-3-trifluoromethyl) -Phenoxy) -2,5-dimethyl-phenyl) -N-ethyl-N-methylformamidine, N'-(2-methyl-5-trifluoromethyl-4- (3-trimethylsilanyl-propoxy) -phenyl ) -N-Ethyl-N-Methylformamidine and N'-(5-difluoromethyl-2-methyl-4- (3-trimethylsilani) Other fungicides selected from the group consisting of ru-propoxy) -phenyl) -N-ethyl-N-methylform amidine.

Herbicides: C1) Acetyl CoA carboxylase inhibitors (ACC), eg, cyclohexenone oxime ethers such as alloxydim, cretodim, cloproxydim, cycloxidim, setoxydim, tralcoxydim, butroxydim, clefoxydim or teplaroxydim. : Crozinahoppropargyl, cihalohopbutyl, diclohopmethyl, phenoxapropethyl, phenoxaprop-P-ethyl or fenthiapropethyl, fluazihopbutyl, fluazihop-P-butyl, haloxyhop Phenoxyphenoxypropionic acid esters such as ethoxyethyl, haloxihopmethyl, haloxihop-P-methyl, isoxapyrihop, propaxahop, xarohopethyl, xarohop-P-ethyl or xalopip tefryl: or furan Arylaminopropionic acid such as propropmethyl or furanpropisopropyl; C2) acet lactate synthase inhibitor (ALS), such as imazapill, imazakin, imazamethabnes-methyl (imazame), imazamox, imazapic or imazetapill. Imidazolinone; pyrimidyl ethers such as pyrithiobacic acid, pyritiobax sodium, bispyrivac-sodium, KIH-6127 or pyribenzaxym; sulfonamides such as floraslam, flumethoslam or metoslam; Bensulfuron Methyl, Chlorimron-Ethyl, Chlorsulfuron, Synosulfuron, Cyclosulfamron, Etamethosulfuron Methyl, ethoxysulfuron, Frazasulfuron, Harosulfuron Methyl, Imazosulfuron, Methosulfuron Methyl, Nicosulfuron, Primisulfuron Methyl, Like prosulfuron, pyrazosulfuron-ethyl, limsulfuron, sulfomethurone methyl, thifensulfuronmethyl, triasulfuron, tribenuron-methyl, triflusulfuronmethyl, tritosulfone, sulfosulfuron, horamsulfuron or iodosulfone. Methylurea; C3) For example, aridchlor (CDAA), benzoylprop-ethyl, bromobutide, chlortiamide , Diphenamide, etobenzanide, fluthamide, hosamine, or amides such as monalde; C4) auxin herbicides such as pyridinecarboxylic acids such as clopyralid or picrolam; or 2,4-D or benazoline; C5 ) Auxin transport inhibitors such as naptalame or diflufenzopill; C6) Carotenoid biosynthesis inhibitors such as benzophenap, chromazone, diflufenican, fluorochloridone, fluridone, pyrazolinete, pyrazoxifene, isoxaflutol. , Isoxachlortoll, Isoxaflutol, Mesotrione, Sulcotrione (Chlormeslon), Ketospiradox, Flurutamon, Norflurazone or Amitrol; C7) Enolpyrvir silicate-3-phosphate synthase inhibitor (EPSPS) ), For example, glyphosate or sulfosate; C8) glutamine synthase inhibitor, eg, viranaphos or gluhosinate-ammonium; C9) lipid biosynthesis inhibitor, eg, anilides such as anilophos or mephenacet; dimethenamide, S-dimethenamide, acetochlor. , Alachlor, Butachlor, Butenachlor, Dietatylethyl, Dimethachlor, Metazachlor, Metrachlor, S-Metrachlor, Pretilachlor, Propachlor, Prinachlor, Telbuchlor, Tenilchlor or Xylolaclol chloroacetoanilides; Butyrate, Cycloate, Dirate , Dimepiperate, EPTC. Thiourea such as esprocarb, molinate, pebrate, prosulfocarb, thiobencarb (benchocalve), trilate or vemolate, or benfresate or perfluidon; C10) thread splitting inhibitors such as ashram, carbetamid. , Chlorprofam, olbencarb, propyzamide, propam or carbamate such as thiocarbadyl; dinitroaniline such as benefin, butraline, dinitramin, etalflularin, fluchloralin, oryzarin, pendimethalin, prodiamine or triflularin; Alternatively, a pyridine such as thiazopill; or butamiphos, chlortaldimethyl (DCPA) or hydrazide maleate; C11) protoporphyrinogen IX oxidase inhibitors such as acifluorfen, acifluorfen-sodium, acronifen, bifenox, chloronitrofen. Diphenyl ethers such as (CNP), ethoxyphen, fluorodiphen, fluoroglycofenethyl, fomesaphen, fryloxyphene, lactophen, nitrofen, nitrofluorfen or oxyfluorfen; oxadiazole such as oxadialgyl or oxadiazone; azaphenidine, butaphenacyl , Calfentrazone, Calfentrazone Ethyl, Sinidon-Ethyl, Flumicrolacpentyl, Flumioxazine, Flumipropine, Flupropacil, Fluthiaset Methyl, Sulfentrazone or Cyclic imides such as Thidiadimin; or ET -751, pyrazoles such as JV 485 or nipyracrofen; C12) photosynthesis inhibitors such as propanyl, pyridate or pyridafo; benzothia dinones such as bentazone; dinitrophenols such as bromophenoxime, dinoceb, dinosebacetate, Dinoterub or DNOC; cyperquat-chloride, difenzoquat-methylsulfate, diquat or dipyridylene such as paracot dichloride; chlorbromron, chlorotorlon, diphenoxuron, dimeflon, diuron, ethidirmone, phenuron, fluo Ureas such as meturon, isoproturon, isouron, linurone, metabenzthiazulone, methazol, metobendurone, methoxurone, monolinuron, nebron, sidurone or tebutyuron; phenols such as bromoxynyl or ioxynyl; chloridazone; amethrin, atrazine, cyanazine, desmain , Dimetamethrin, hexadinone, prometon, promethrin, propazine, simazine, simetrin, terbumeton, terbutrin, terbutyrazine or triazine such as trietazine; triazine such as metamitron; uracil such as bromacil, renacil or terbacil; Biscarbamate such as; C13) synergists such as oxylans such as tridiphan; C14) CIS cell wall synthesis inhibitors such as isoxaben or diclobenil; C16) various other herbicides such as dichloropropionic acid such as dalapon. Dihydrobenzofurans such as etofumesate; phenylacetic acid such as chlorphenac (fenac); or adiprotrin, barban, benzlide, benzthiazulone, benzofluol, buminaphos, butidazole, buturon, cafentrol, chlorbufam, chlorphene Propmethyl, chloroxron, symmethyrine, cumyllon, cyclulon, cyprazine, cyprazole, dibenzyllon, dipropetrin, dimulon, egrinadinethyl, endtal, etiodin, flucabazone, fluorventranyl, flupoxam, isocarbamide, isopropalin, carbutyrate, mefluidide, Monuron, napropamide, napropanilide, nitraline, oxacyclomefone, phenisoam, piperophos, prussine, proflualin, pyribticalve, sekbumethone, sulfarate (CDEC), terbucarb, triaziflam, triazophenamide or trimethurone; Environmentally compatible salt.

Repellents include, but are not limited to, dimethyl anthranilate, methyl anthranilate, ethyl anthranirate, phenylethyl anthranilic acid and menthyl anthranilate and their environmentally compatible salts, N, N-diethyl-meth-toluamide (DEET), Includes picaridin, lemon eucalyptus oil, citronella, 2-undecanone, ethylbutylacetylaminopropionate (IR3535), A13-37220, essential oil of yomogi, amitrazu, permethrin, dimethylphthalate, R-11 and ethylhexanediol.

In another aspect of the invention, the consumer care product is described as repelling insects and / or tick pests. Consumer care products are not particularly limited, such as pheromones, essences, anthranilic acid esters, O-aminoacetophenone, N, N di-ethyl-3-methylbenzamide or N, N diethyl-m-toluamide (DEET). Repellent oils such as methylbenzamide, tea tree oil, lemongrass oil, citronella oil, eucalyptus oil, lavender oil, geranium oil, chow oil, kayapte oil and lemon balm oil, and insects such as fatty acids or any mixture thereof. Or include topical compositions applied to skin, clothing or other materials to repel insects and / or tick pests, including tick repellent ingredients. In certain embodiments of the invention, the product is in liquid or semi-solid form and may be aqueous, non-aqueous or a combination thereof, lotions, creams, ointments, solutions, foams, gels, solid sticks, aerosols. , Sticks, liquids, pastes, powders, roll-ons, sheets, sprays, sticks, tablets, suspensions, emulsions, microemulsions, emulsions and the like. The formulation may be designed to be gradually released from the patch or sprayed from a canister, delivery device or any suitable delivery system.

The carrier can include all carriers described herein, topical cosmetic carriers and pharmaceutically acceptable carriers. The carriers are water, alcohol, aldehyde, alkane, alkane, amide, amine, diglyceride, ester, ether, glycol ether, fat, fatty acid, glycol ester, ketone, lanolin, mineral oil, monoglyceride, paraffin oil, polyethylene glycol, vaseline, , Propylene carbonate, silicone, tall oil, terpene hydrocarbons, terpene alcohols, triglycerides, finely divided organic solid materials, finely divided inorganic solid materials and mixtures thereof. In one embodiment, the carrier can be an alcohol selected from aromatic alcohols, monohydric alcohols of C1-C6, polyhydric alcohols of C2-C6, polyhydric alcohols and mixtures thereof. As one example, the carrier is an alcohol selected from methanol, ethanol, propanol, butanol, sec-butanol, tert-butanol and mixtures thereof. As a particular example, the carrier in the supplied composition is ethanol. As another specific example, the composition comprises a carrier that is isopropanol.

In a more preferred embodiment, the composition comprising an insect or tick repellent comprises a topical cosmetic carrier and / or a pharmaceutically acceptable carrier to form a topical cosmetic or pharmaceutical composition applicable to the skin.

In certain embodiments, the carrier is, but is not limited to, almond oil, avocado oil, canola oil, cashew oil, cherry seed oil, cocoa butter, coconut oil, corn oil, cottonseed oil, flaxseed oil, grape seed oil, jojoba. Selected from the group comprising oils, macadamia nut oils, olive oils, palm oils, palm fruit oils, peanut oils, rapeseed oils, rice oils, benivana oils, sesame oils, soybean oils, sunflower oils and walnut oils and combinations thereof.

In certain embodiments, the carrier can be diethyl ether, isopropyl ether, n-propyl ether or a combination thereof. In one example, the carrier is acetone, methyl ketone, methyl benzyl ketone, methyl ethyl ketone, methyl isopropyl ketone, methyl butyl ketone, ethyl ketone, benzyl methyl ketone and combinations thereof. In other forms, the carrier is ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol dimethyl ether, methylene glycol, methylene glycol monomethyl ether, methylene glycol dimethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol dimethyl ether, butylene glycol, butylene. It can be glycol monomethyl ether, butylene glycol dimethyl ether or a combination thereof. In another example, the carrier is ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol dimethyl ether, methylene glycol, methylene glycol monomethyl ether, methylene glycol dimethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol dimethyl ether, butylene glycol, butylene glycol. It can be monomethyl ether, butylene glycol dimethyl ether or a combination thereof.

In certain embodiments, the carrier can be a finely divided organic solid material or a finely divided inorganic solid material. In certain more preferred embodiments, the carrier can be fine powder, granules, powder or salt crystals. In other embodiments, the carrier is alumina, amorphous silica, attapulsite, calcium carbonate, calcium phosphate, clay, cyanide, diatomaceous soil, fumed silica, kaolin, magnesium carbonate, fine particulate cellulose, montmorillonite, pyrophyllite, silicic acid. It can be acid, sodium hydrogencarbonate, sodium carbonate, sodium phosphate, sodium pyrophosphate, talc, vermiculite or a combination thereof.

In certain embodiments, the carrier can be an aerosol propellant selected from argon, butane, carbon dioxide, chlorofluorocarbons, dimethyl ether, hydrocarbons, hydrofluorocarbons, isobutane, nitrogen, propane and mixtures thereof. .. In certain examples, the aerosol propellant comprises difluoromethane, trifluoromethane, difluoroethane, trifluoroethane, tetrafluoroethane or octafluorocyclobutane or a combination thereof.

In other embodiments, the carrier can be a silicone oil selected from cyclic silicones, linear or branched non-cyclic silicones and combinations thereof. In one embodiment, the silicone oil can be selected from volatile and non-volatile silicones. In another embodiment, the silicone oil contains a cyclic polydimethylpolysiloxane containing an average of about 3 to about 9 silicon atoms and a direct containing about 3 to about 9 silicon atoms on average. A volatile silicone oil selected from chain polydimethylpolysiloxane. In other embodiments, the silicone oil is dimethicone copolypoly, cyclomethicone, polydimethylsiloxane, cyclic dimethylpolysiloxane, aminosilicone, phenylsilicone, diphenyldimethicone, phenyltrimethicone, cyclopentasiloxane, dimethyl-siloxane and poly. A non-volatile silicone oil selected from polymers with oxyethylene and / or polyoxypropylene, dimethicone copolypoly, cetyl dimethicone copoly polyol, cetyl dimethicone, cetyl dimethicone copolypoly and dimethicone and combinations thereof. In a further example, the carrier is a silicone oil selected from polydimethylsiloxane, phenylated silicone, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane and octamethylcyclo-tetrasiloxane.

In certain embodiments, the carrier is selected from, but not limited to, monoglyceride, diglyceride, acetylated monoglyceride, or triglyceride, or a combination thereof. In one example, the carrier is 1-propanol, 2-propanol, 1-butanol, 2-butanol, 2-methyl-1-propanol, 1-pentanol, 2-pentanol, 3-methyl-1-butanol, 3 -Methyl-2-butanol, ethylene glycol, propylene glycol, 1,4-butanediol, 1,3-butanediol, 2-methyl-1,3-propanediol, 1,4-cyclohexanedimethanol, diethylene glycol, triethylene Glycol, PEG-200, PEG-300, PEG-400, PEG-600, 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, 2-isopropanolethanol, 2-butoxyethanol, 1-methoxy-2- Propanol, 1-ethoxy-2-propanol, 3-methoxy-1-butanol, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, diethylene glycol mono-isopropyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether , Glycene, 3-methoxy-1,2-propanediol or 3-ethoxy-1,2-propanediol.

In other embodiments, the carrier comprises borneol, citronellol or geraniol or a combination thereof. In other embodiments, the carrier comprises or consists of a cyclodextrin selected from α-cyclodextrin, β-cyclodextrin or γ-cyclodextrin or a combination thereof.

In certain embodiments, the consumer care products described herein are a composition comprising a repellent for insects or mites described herein and a delivery vehicle that delivers the composition to a selected location. And include. The delivery vehicle can include water, aerosols, creams, gels, lotions, oils, sprays, soaps, detergents, particles or substrates. In other embodiments, the delivery vehicle can be a substrate that is the material of paper, garment or woven or non-woven fabric. In one embodiment, the substrate is a non-woven fabric material that is a flexible sheet containing an adhesive or heat-bonded fibers. The fibers can be selected from cellulose esters, cotton, linen, jute, linen, ramie, rayon, polyamides, polyester polyolefins, polypropylene, polyvinyl derivatives, silk, sisal asa and wool and combinations thereof.

In certain embodiments, the delivery vehicle is agar, carbomer, carboxyvinyl polymer, divendylidene alditol, carboxypolymethylene, collagen, dextrin fatty acid ester, gelatin, styrene hydride / isoprene copolymer, 12-hydroxysteare. Acids, K-carrageenan, gellan gum, low hydroxycellulose, pectin, polyacrylic acid, styrene-ethylene / propylene block copolymers, styrene-ethylene / butylene-styrene block copolymers, sucrose fatty acid esters and waxes and combinations thereof. It can be a gel containing a gelling agent selected from. In other embodiments, the delivery vehicle can be a fluid that forms a gel in situ when dispensed. The fluids are agar, alginate, carbomer, carboxyvinyl polymer, dibenzylidene alditol, carboxypolymethylene, collagen, dextrin fatty acid ester, gelatin, styrene hydride / isoprene copolymer, 12-hydroxystearic acid, K-carrageenan, Gelation selected from gellan gum, low hydroxycellulose, pectin, polyacrylic acid, styrene-ethylene / propylene block copolymers, styrene-ethylene / butylene-styrene block copolymers, sucrose fatty acid esters and waxes and combinations thereof. Can include agents.

In certain embodiments, the delivery vehicle is alumina, amorphous silica, attapulsite, calcium carbonate, calcium phosphate, clay, caustic, diatomaceous soil, fumed silica, kaolin, coconut soil, magnesium carbonate, fine particulate cellulose, montmorillonite, pyro. It may contain or consist of fine particles selected from Philite, silicic acid, sodium hydrogen carbonate, sodium carbonate, sodium phosphate, sodium pyrophosphate, talc, vermiculite and combinations thereof.

In certain embodiments, the insects or mites repelled by the compositions described herein are Ctenocephalides feels, Ctenocephalides canis, Xenopsilla cheopis, Pulexisr. , Sunanomi (Tunga penetrans) and fleas insects such as European rat flea (Nosopsyllus fasciatus); head lice (Pediculus humanus capitis), crab louse (Pthirus pubis), Ushijirami (Haematopinus eurysternus), Hitsujijirami (Dalmalinia ovis), Butajirami (Haematopinus suis ), Linognathus vitili, Uchihajirami (Bobicola bovis), Chicken Hajirami (Menopon gallinae), Fukuromaruhajirami (Menacanthus stramineus), Kebukaushira Shirami insects such as the genus Kejirami and the genus Solenopotes; Amblyomma americanum), Oshidani, Kuriirokoitamadani, Ixodes-holoticuls, Pacific ticks, Anderson ixodidae, Ambrion mamakratum, Octodectes cynotis , Mimihizendani, Sarcoptes, Drosophila, Niwatorihizendani, Hizendani, Nikibidani, Demodex canis, Ormithonyssus syviarum, Derman Ornithodoros hermsi, Ornithodorus turicata, Ornithodorus bacoti, Acarapis sp. ), Cheyletiella spp., Ornithocheyletia spp., Myobia spp. Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Carophagus spp., Caroglyphos spp. (Hypodectes spp.), Pterolichus spp., Cytodites spp. And Laminosioptes spp. Cimex hemipterus, Reduvius senilis, Triatoma spp., Rodnius spp., Panstrongirus sp. Heterogeneous insects such as; and Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Wernequera sp. Spp.), Lepicentron spp., Trichodectes spp. And Felicola spp. Are selected from insects that are Ambrycera and Ischnocera insects. can.

In certain embodiments, the insects or mites repelled by the compositions described herein are ants, tokojirami, himemaru hornets, mukade, hornets, drain flies, dust mites, biting mites, wasps, flies, flies, It can be an insect selected from buyo, spider bee, house dust mites, yasde, other mites, mosquitoes, cockroaches, scabs, house dust mites, spiders, turtles, termites, mites, jig bees, elephants and wasps. In certain embodiments, the compositions comprising the insect and mite repellents described herein are at least 1 day, or at least 2 days, or at least 3 days, or at least 4 days, or at least 5 days, or At least 6 days, at least 7 days, or at least 8 days, or at least 9 days, or at least 10 days, or at least 11 days, or at least 12 days, at least 13 days, at least 14 days, or at least 15 days, or at least 16 days. Or at least 17 days, or at least 18 days, or at least 19 days, at least 20 days, or at least 21 days, or at least 22 days, or at least 23 days, or at least 24 days, or at least 25 days, at least 26 days, or Prescribed for delivery for at least 27 days, or at least 28 days, or at least 29 days, or at least 30 days, or at least 31 days, or at least 45 days, or at least 60 days, or at least 75 days, or at least 90 days. Will be done.

Also, in certain embodiments, a woven or non-woven fabric comprising a cellulosic substrate covered or impregnated with, but not limited to, a fabric-treated composition and a composition comprising the insect and tick repellents described herein. Includes fabric-treated sheets, including sheets or other substrates. The cloth-treated composition can be a detergent composition or a cloth softening composition. In some embodiments, the cloth-treated composition is selected from anionic surfactants, nonionic surfactants, amphoteric ionic surfactants, amphoteric and cationic surfactants and mixtures thereof. A detergent composition containing a detergent. In other embodiments, the cloth-treated composition comprises monomethyltrialkyl quaternary, imidazolinium quaternary, dimethylalkylbenzyl quaternary, dialkyldimethylquaternary, methyldialkoxyalkyl quaternary, diamideamine-based quaternary and A cloth softening composition comprising a dialkylmethylbenzyl quaternary or (C8-C24) fatty acid amide or a combination thereof.

In certain embodiments, it comprises a liquid fabric treatment composition comprising a fabric softener or fabric conditioner and a composition comprising the insect and mite repellents described herein. The cloth softeners are monomethyltrialkyl quaternary, imidazolinium quaternary, dimethylalkylbenzyl quaternary, dialkyldimethyl quaternary, methyldialkoxyalkyl quaternary, diamideamine-based quaternary and dialkylmethylbenzyl quaternary, (C8). -C24) It can be selected from fatty acid amides and combinations thereof. In some embodiments, the fabric conditioner comprises an antistatic agent, a brightener, a thickener, an antifouling agent, an anti-wrinkle agent or a combination thereof. In certain embodiments, the fabric conditioner is an antistatic agent comprising a tertiary amine, a quaternary amine, aluminum stearate or a combination thereof. In another example, the cloth conditioner is a brightener comprising hydrogen peroxide, potassium permanganate, sodium peroxide, sodium perborate, disulfonated diaminostilben optical brightening compounds and triazole optical brightening compounds. Also, in other embodiments, the cloth conditioner is a thickener selected from carboxymethyl cellulose, hydroxyethyl cellulose, starch, polyvinyl acetate and combinations thereof. Further, in another embodiment, the cloth adjusting agent is an anti-wrinkle agent containing polyvinyl acetate.

In certain embodiments, a cloth refresh spray composition comprising a composition for killing or repelling the pests described herein is comprising, wherein the active ingredient is (about) 0.1% by weight in the composition. To (about) 5% by weight, or (about) 1% to (about) 10% by weight, or more than 10% by weight, or more than 15% by weight, or It is present in an amount greater than 20% by weight or in an amount greater than 25% by weight. The cloth refresh spray composition further comprises cyclodextrin; and / or amphoteric surfactants, anionic surfactants, cationic surfactants, nonionic surfactants or amphoteric surfactants or combinations thereof; and / Or it can contain water.

In certain embodiments, a wet tissue product comprising a substrate and a solution or emulsion of a composition comprising the insect or mite repellent described herein comprises a wet tissue product, wherein the active ingredient is at least 0. It is present in an amount of 1% by weight. In addition, wet wipe products can include, but are not limited to, surfactants, including, but not limited to, cocamidopropyl betaine, coco glucoside, or decyl glucoside, or a combination thereof. In one embodiment, the substrate in the wet wipe product is a non-woven fabric or a cellulosic material.

Further, in a specific embodiment, a container containing the composition containing the insect or mite repellent described herein, or an absorption sheet impregnated with the composition containing the insect or mite repellent described herein. Includes a packaged pest repellent composition, including. Other embodiments include pressure sprayable pest control or agricultural pesticide products for aerosol propellants, including compositions comprising the insect or mite repellents described herein. The propellant in the pressure sprayable pest control agent or agricultural pesticide product of the aerosol propellant can include carbon dioxide, propane, butane or a mixture thereof.

Certain embodiments include a method of repelling an insect or pest from a location using a composition comprising the insect or mite repellent described herein. In the method supplied, the composition comprising the insect or mite repellent described herein was placed in place in an insect or pest repellent amount and the insect or pest entered and contacted the composition. Occasionally or by steam from its composition. In certain embodiments, the composition is atomized, brushed, coated, soaked, soaked, dropped, sprinkled, in at least a portion of the location. Arranged by foaming, injecting, injecting on or inside the surface, pouring, rolling on, dispersing, spraying, spreading, sprinkling or wiping.

In certain embodiments of methods of repelling insects or pests from a location, the location is the surface of the human or animal body. For example, the animal can be a pet animal or livestock. In another embodiment of the method, the composition is placed by being applied topically to an article of human clothing. In another embodiment of the method, the composition comprising the insect or mite repellent described herein washes an article of human clothing with a detergent or fabric softener containing the composition or both. Be placed by. Also, in another embodiment of the method, the composition is placed by drying an article of human clothing with a fabric softener containing the composition. The softener can be supplied as a dryer sheet or gel. In another embodiment of the method, the location is the surface of the skin, hair or hair, the composition of which is placed by being applied topically to the skin, hair or hair. Topically applied compositions can be supplied as aerosols, solutions, emulsions, oils, lotions, soaps, sprays or gels. Also, in other embodiments of the method, the composition is a skin conditioner, hand / body / facial lotion, skin moisturizer, lotion, skin disinfectant, skin cleansing composition, skin smoothing and Lubricating composition, sunscreen products, anti-aging products, sun-tanning products, self-tanning products, after-sun products, masking products, anti-wrinkle products, hair conditioners, hair styling gels, anti-skinning compositions, hair growth-enhancing compositions, hair Lotion, Hair Tonic, Rinse, Conditioner, Hair Color Composition, Hair Anti-Chinese Composition, Hair Shining Composition, Moose, Styling Gel, Hair Pomade Products and Hair Sprays, Soaps, Foam Bath Products, Hands / Body / Facials It is supplied to the surface of the skin, hair or hair in a form selected from cleansers, astringent cleansers, anti-acne products, shampoos, body shampoos, solid synthetic detergents, shower gels and shampoos.

In certain embodiments of methods of repelling insects or pests from a location, the location is the location of bedding. Compositions comprising the insect or mite repellents described herein can be atomized, coated, soaked, soaked, dropped, sprinkled, foamed, infused. Bedding, bedboards, bed slats, mattresses, box springs, furniture, by injecting, pouring, rolling on, dispersing, spraying, spreading, rolling or wiping on or inside the surface. It can be placed on a carpet, baseboard or floorboard or a combination thereof. In other embodiments of the method, the compositions comprising the insect or mite repellents described herein are bedding, bedboards, bed slats, mattresses, box springs, furniture, carpets, baseboards or floorboards. Alternatively, the composition is placed on the surface of a combination thereof by spraying. For example, a composition comprising an insect or mite repellent described herein can be injected by injecting the composition into a mattress, box spring, furniture, carpet, baseboard or floorboard or a combination thereof. Can be placed. In certain embodiments of the method, the location comprises space in a wood structure, wood structure or wall.

In other embodiments of the method, the location is an air supply duct, attic, awning, basement, basement, underfloor, deck, dock, garage, large basket, waste heat outlet, house foundation, linen storage, etc. Selected from pool decks, tiles, shipping containers, storage equipment, suitcases, sidewalks and wall spaces, the composition is to atomize or coat the composition on or in at least a portion of the location. That, soaking, soaking, dripping, sprinkling, foaming, injecting, injecting on or inside the surface, pouring, rolling on, dispersing, spraying, spreading Placed by things, sowing or wiping. For example, a composition comprising an insect or mite repellent described herein can be applied by spraying the composition onto a surface or supplied in powder form and the powder composition on the surface. It is applied by sprinkling. Also, in another embodiment of the method for repelling insects or pests from a location, the composition comprising the insect or tick repellent described herein is an absorption containing the composition at that location. It is placed by supplying and positioning a sex substrate or gel. In one example, the absorbent substrate comprises a non-woven fabric or a cellulosic material.

In certain embodiments, insects or pests are, but are not limited to, ants, silverfish, Himemaru silverfish, mukade, hornets, drain flies, dust mites, wasps, fleas, flies, buyo, wasps, hornets, and other mites. , Moss, cockroaches, pests, silverfish, spiders, turtles, termites, mites, bees, hornets and wasps. For example, in the fed method, the insect or pest is an ant selected from Argentine ants, black ants, ants, hiari, odorous house ants, pavement ants and pharaoh ants. In other embodiments, the insect or pest is a louse selected from head lice, body lice, hair lice and eggs thereof.

In certain embodiments, the compositions comprising the insect or mite repellents described herein are by topical application to human clothing articles; or topically to human skin or hair. By being applied to; or by being applied topically to the skin or hair of an animal. In some embodiments, the animal can be selected from cattle, dogs, goats, deer, cricetine, cats, chickens, horses, rabbits, rats, Mustelidae and sheep. For example, animals are pet animals. In another embodiment, the composition comprising the insect or tick repellent described herein is to wash an article of human clothing with a detergent or fabric softener containing the composition, or both. Alternatively, it can be placed by drying the article of human clothing with a fabric softener containing the composition.

In certain embodiments, the compositions comprising bed bug repellents described herein include bed bugs, or bedding, bedboards, bed slats, mattresses, boxsprings, etc. Placed by applying directly to the surface of furniture, carpets, baseboards or floorboards or combinations thereof. For example, the application of a composition comprising an insect or tick repellent described herein is to spray the composition onto the surface of bedding, bedboards, bed slats, mattresses, box springs, furniture or carpets. Or injecting the composition into a mattress, box spring, furniture or carpet or a combination thereof; or steam from the composition with the surface of a bedboard, bed slats, mattress, box spring, furniture or carpet. Placing an absorbent substrate or gel containing the composition near a bedboard, bed slats, mattress, box spring, furniture or carpet for contact; or injecting the composition into a wall space. Can be included. In certain embodiments, the absorbent substrate comprises a non-woven fabric or cellulosic material.

In one embodiment that provides a method for eliminating bed bugs, the compositions comprising the insect or mite repellents described herein are from (about) 0.01% to (about) 0.01% of the active ingredient, fatty acid and carrier. ) Includes up to 10%, or more than 10%, or more than 15%, or more than 20%, or more than 25%, or up to 90%. In some embodiments, the composition is formulated to deliver the active ingredient for at least 4 days. In some of the methods described herein, the composition is prepared for at least 1 day, or at least 2 days, or at least 3 days, or at least 4 days, or at least 5 days. , Or at least 6 days, or at least 7 days, or at least 8 days, or at least 9 days, or at least 10 days, or at least 11 days, or at least 12 days, For at least 13 days, at least 14 days, or at least 15 days, or at least 16 days, or at least 17 days, or at least 18 days, or at least 19 days, or at least 20 days. Between days, or at least 21 days, or at least 22 days, or at least 23 days, or at least 24 days, or at least 25 days, at least 26 days, or at least 27 days. Between, or at least 28 days, or at least 29 days, or at least 30 days, or at least 31 days, or at least 45 days, or at least 60 days, or at least 75 days. , Or can be formulated to deliver the active ingredient for at least 90 days.

In certain embodiments, the composition for killing or repelling the insects disclosed herein is supplied and the composition is applied to the surface to injure the skin due to biting of the insect or pest. The insect or pest is in contact with a composition comprising an insect or tick repellent disclosed herein, or an insect or tick repellent disclosed herein. It is repelled from its surface when in contact with the vapor of the composition containing it. In some embodiments, the surface is clothing or bedding, and the composition comprising the insect or mite repellent disclosed herein atomizes a predetermined amount of the composition onto the surface. Transforming, coating, soaking, soaking, dripping, sprinkling, foaming, injecting, injecting on or inside the surface, pouring, rolling on, dispersing, It can be supplied to its surface by spraying, spreading, rolling or wiping. In other embodiments of the supplied method, the composition comprising the insect or mite repellent disclosed herein is provided herein as a detergent composition, a fabric softener composition, or both. It is applied by washing clothes or bedding with a composition containing a repellent for insects or mites disclosed in. In another embodiment of the supplied method, the composition comprising an insect or mite repellent disclosed herein dries clothing or bedding with the composition provided as a fabric softener composition. By doing so, it can be applied. In some embodiments of the method, the surface is a bedboard, bed slats, mattress, box spring, furniture or carpet, the composition of which atomizes the composition onto the surface. Coating, soaking, soaking, dripping, sprinkling, foaming, injecting, injecting on or inside the surface, pouring, rolling on, dispersing, spraying, It can be applied by spreading, rolling or wiping. Also, in another embodiment of the method, the composition comprising the insect or mite repellent disclosed herein can be provided in powder form, the powder composition on its surface. It is applied by sprinkling things.

In some embodiments of methods of preventing skin injuries from biting insects or pests, the surface thereof is human skin or hair and comprises the insect or mite repellents disclosed herein. The composition can be applied topically to its skin or hair. In embodiments, the compositions comprising the insect or mite repellents disclosed herein can be supplied as aerosols, solutions, emulsions, oils, lotions, soaps, sprays or gels. Also, in other embodiments, the composition is a skin conditioner, hand / body / facial lotion, skin moisturizer, lotion, skin disinfectant, skin cleansing composition, skin smoothing and lubricating composition. Products, sunscreen products, anti-aging products, sun-tanning products, self-tanning products, after-sun products, masking products, wrinkle-removing products, hair conditioners, hair styling gels, anti-skinning compositions, hair growth-enhancing compositions, hair lotions, hair Tonic, conditioner, conditioner, hair color composition, hair anti-skinning agent composition, hair shining composition, mousse, styling gel, hair pomade products and hair spray, soap, foam bath products, hand / body / facial cleanser, convergence It is provided in a form selected from cleansers, anti-skin products, shampoos, body shampoos, solid synthetic detergents, shower gels and shampoos. The insect or pest can be selected from ants, bed bugs, bud bugs, fleas, head lice, other mites, mosquitoes, cockroaches, scabies and mites.

In at least one embodiment, the disclosed invention is prepared by a step comprising: (a) mixing the active ingredient and the fatty acid; (b) adding a pharmaceutically suitable topical carrier to the mixture. Includes consumer care products.

In at least one embodiment, the disclosed inventions include repellent pheromones such as necromones or anthranilic acid esters, alone or in combination with aromatic oils. Preferably, the repellent pheromone is present in an amount of 4w / w% to 10w / w%. In another embodiment, the fatty acids in the consumer products according to this claim are saturated and unsaturated fatty acids containing 8 to 24 carbon atoms, more preferably 13 to 21 carbon atoms. include. Examples of fatty acids that may be used are oleic acid, ricinoleic acid, linoleic acid palmitic acid and stearic acid; particularly preferably stearic acid and oleic acid.

In one embodiment, the invention comprises water, surfactants, emulsifiers, skin conditioning or softeners, wetting agents, silicones, anti-inflammatory agents, sunscreens, local anesthetics, vitamins, anti-itching agents, antibiotics, etc. For topical skin care compositions comprising appropriate topical or cosmetic additives such as antifungal agents, preservatives, vasoconstrictors, and other pH regulators, thickeners, antioxidants, preservatives.

In certain embodiments, the composition is further limited to, but not limited to, surfactants, polyvinylpyrrolidone, polyoxyethylated castor oil, polyoxyethylene sorbitan ester, alkylnaphthalene sulfonate, alkylbenzene sulfonate, polyoxyethylene, Polycarboxylate, lignin sulfonate, sodium silicate, potassium silicate, methylcellulose. Includes dispersants selected from carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, gum arabic, polyacrylate and acrylic / maleic acid copolymers, and combinations thereof.

In at least one embodiment, the composition is a surfactant in an amount of 0-40 w / w%, or, but not limited to, anionic compounds, cationic compounds, nonionic compounds, amphoteric compounds. Includes emulsifiers containing compounds such as amphoteric ionic compounds and combinations thereof. Typical, but not limited to, esters, amides, polysaccharide ethers, polyglycosides, fatty acids, fatty alcohols, amine oxides, water-soluble cellulose derivatives, alkyl sulfonates, etc. suitable for use in the present disclosure. Alkoxyylated alkylphenols, alkanolamides, betaines, biionic surfactants, carboxylated alcohols, carboxylic acids, ethoxylated alcohols, preferably ethoxylated C ₁₂ -C ₁₅ alcohols (eg Rhodasurf® L-9 brand). Polysolvate 20, polysolvate 80, alkoxylated alcohol, dialkoxylated alcohol, alkoxylated dialkylphenol, alkylpolyglycoside, alkoxylated alkylphenol, alkoxylated glycol, alkoxylated mercaptan, alkylamine salt, alkyl quaternary amine salt, natural fatty acid Nonionic surfactants such as glyceryl or polyglyceryl esters, alkoxylated glycol esters, alkoxylated fatty acids, alkoxylated alkanolamides, polyalkoxylated silicones and N-alkylpyrrolidones and combinations thereof, phosphoric acid DEA, alkyl sulfonic acid ester interfaces. Activators, linear alkylbenzene sulfonic acid, branched alkylbenzene sulfonic acid, alkyl sulfate esters C12-C18, alkylalkoxy sulfate esters C12-C18, alkylmethylsulfonic acid esters C12-C18 and combinations thereof. Anionic surfactant, behentrimonium metosulfate, alkylamine, alkyldiamine, alkylpolyamine, mono- or di-quaternary ammonium salt, monoalkoxylated amine, dialkoxylated amine, monoalkoxylated quaternary ammonium Includes cationic surfactants such as salts, dialkoxylated quaternary ammonium salts, etheramines, amine oxides, alkoxylated amine oxides and aliphatic imidazolines, and derivatives thereof.

In at least one embodiment, the formulation is in the form of a consumer care product, such as a foaming composition comprising a single emulsifier or a combination of two or more emulsifiers. In at least one embodiment, the formulation comprises both an aqueous layer and an organic layer, the organic layer comprising a surfactant and an organic diluent. In one embodiment, the organic layer may contain active ingredients such as isopropyl myristate and ethoxylated castor oil (eg, Agnique® BP-4-3101 brand).

The dispersant can be present in the composition in an amount of (about) 0.002% by weight to (about) 50% by weight of the composition. In some embodiments, the dispersant is present in an amount of (about) 0.025% by weight to (about) 25% by weight of the composition. In another example, the dispersant is present in an amount of (about) 0.01% by weight to (about) 15% by weight of the composition. Also, in another example, the dispersant is present in an amount of (about) 0.05% to (about) 10% by weight of the composition, eg, at least (about) 0% of the composition. 05% by weight, 0.06% by weight, 0.07% by weight, 0.08% by weight, 0.09% by weight, 0.1% by weight, 0.15% by weight, 0.2% by weight, 0.25% by weight %, 0.3% by weight, 0.35% by weight, 0.3% by weight, 0.35% by weight, 0.5% by weight, 0.55% by weight, 0.6% by weight, 0.65% by weight, 0.7% by weight, 0.75% by weight, 0.8% by weight, 0.85% by weight, 0.9% by weight, 0.95% by weight, 1% by weight, 1.05% by weight, 1.1% by weight %, 1.15% by weight, 1.2% by weight, 1.25% by weight, 1.3% by weight, 1.35% by weight, 1.4% by weight, 1.45% by weight, 1.5% by weight, 1.55% by weight, 1.6% by weight, 1.65% by weight, 1.7% by weight, 1.75% by weight, 1.8% by weight, 1.85% by weight, 1.9% by weight, 1. 95% by weight, 2% by weight, 2.05% by weight, 2.1% by weight, 2.15% by weight, 2.2% by weight, 2.25% by weight, 2.3% by weight, 2.35% by weight, 2.4% by weight, 2.45% by weight, 2.5% by weight, 2.55% by weight, 2.6% by weight, 2.65% by weight, 2.7% by weight, 2.75% by weight, 2. 8% by weight, 2.85% by weight, 2.9% by weight, 2.95% by weight, 3% by weight, 3.05% by weight, 3.1% by weight, 3.15% by weight, 3.2% by weight, 3.25% by weight, 3.3% by weight, 3.35% by weight, 3.4% by weight, 3.45% by weight, 3.5% by weight, 3.55% by weight, 3.6% by weight, 3. 65% by weight, 3.7% by weight, 3.75% by weight, 3.8% by weight, 3.85% by weight, 3.9% by weight, 3.95% by weight, 4% by weight, 4.05% by weight, 4.1% by weight, 4.15% by weight, 4.2% by weight, 4.25% by weight, 4.3% by weight, 4.35% by weight, 4.4% by weight, 4.45% by weight, 4. 5% by weight, 4.55% by weight, 4.6% by weight, 4.65% by weight, 4.7% by weight, 4.75% by weight, 4.8% by weight, 4.85% by weight, 4.9% by weight. % 4.95% by weight, 5% by weight, 5.05% by weight, 5.1% by weight, 5.15% by weight, 5.2% by weight, 5.25% by weight, 5.3% by weight, 5. 35% by weight, 5.4% by weight, 5.45% by weight, 5.5% by weight, 5.55% by weight, 5.6% by weight, 5.65% by weight, 5.7% by weight, 5.75% by weight. % 5.8% by weight, 5.85% by weight, 5.9% by weight, 5.95% by weight, 6% by weight, 6.05% by weight, 6.1. Weight%, 6.15% by weight, 6.2% by weight, 6.25% by weight, 6.3% by weight, 6.35% by weight, 6.4% by weight, 6.45% by weight, 6.5% by weight. , 6.55% by weight, 6.6% by weight, 6.65% by weight, 6.7% by weight, 6.75% by weight, 6.8% by weight, 6.85% by weight, 6.9% by weight, 6 .95% by weight, 7% by weight, 7.05% by weight, 7.1% by weight, 7.15% by weight, 7.2% by weight, 7.25% by weight, 7.3% by weight, 7.35% by weight. , 7.4% by weight, 7.45% by weight, 7.5% by weight, 7.55% by weight, 7.6% by weight, 7.65% by weight, 7.7% by weight, 7.75% by weight, 7 8.8% by weight, 7.85% by weight, 7.9% by weight, 7.95% by weight, 8% by weight, 8.05% by weight, 8.1% by weight, 8.15% by weight, 8.2% by weight. , 8.25% by weight, 8.3% by weight, 8.35% by weight, 8.4% by weight, 8.45% by weight, 8.5% by weight, 8.55% by weight, 8.6% by weight, 8 .65% by weight, 8.7% by weight, 8.75% by weight, 8.8% by weight, 8.85% by weight, 8.9% by weight, 8.95% by weight, 9% by weight, 9.05% by weight. , 9.1% by weight, 9.15% by weight, 9.2% by weight, 9.25% by weight, 9.3% by weight, 9.35% by weight, 9.4% by weight, 9.45% by weight, 9 5.5% by weight, 9.55% by weight, 9.6% by weight, 9.65% by weight, 9.7% by weight, 9.75% by weight, 9.8% by weight, 9.85% by weight, 9.9. It is present in amounts of% by weight, 9.95% by weight and 10% by weight.

In other embodiments, the composition may contain one or more thickeners. In one embodiment, the thickener is about 0-40% by weight, preferably about 0.1% by weight to about 30% by weight, and even more preferably about 0.25% to about 15% by weight of the composition. Present at the weight% level. A non-limiting class of thickeners include useful carboxylic acid polymers such as carbomer, B.I. F. Includes those selected from acrylic acids cross-linked with allyl ethers of sucrose or pentaolitritor, commonly available as Goodrich's Carbopol series. Other thickeners include crosslinked polyacrylate polymers, polyacrylamide polymers, cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl hydroxyethyl cellulose, Includes microcrystalline cellulose, polysaccharides or gelling agents such as cellulose cellulose sulfate, and mixtures thereof. Other thickeners include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectrite, hyaluronic acid. , Silica, hydroxypropylchitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, nutto gum, potassium alginate, carrageenan potassium, propylene glycol alginate, mycorrhizal gum, carboxymethyl dextran sodium, carrageenan sodium, tragacanto gum, xanthan gum (Kelzan) Includes registered trademark)) and mixtures thereof.

In at least one embodiment, the topical composition further comprises one or more topical anesthetics (or multiple topical anesthetics). Preferably, the topical composition is lidocaine. In other embodiments, one or more of the following may be used in place of or in addition to lidocaine: benzocaine, butamben, dibucaine, oxybuprocaine, pramocaine, proparacaine, proxymethocaine, tetracaine. , Amethocaine, proxykine, mepivacaine, bupivacaine, etc., and mixtures and equivalents thereof.

In at least other embodiments, the anti-inflammatory agent is a non-steroidal agent such as diclofenac, naproxene salicylate, ketrolac or a corticosteroid such as hydrocortisone, prednisolone, cortisol; dexamethasone, arcomethasone; hydrocortisone 21-acetate; hydrocortisone. 17-Valelate; Hydrocortisone 17-Buchilate; Betamethasone 17,21-dipropionate; Dexamethasone Acetonide; Betamethasone Valerate; Prednisolone; Fluorometron; Fluchloronide; Cortisol acetate; Flunisolide acetate; Triamcinolone acetate; Mixtures; and their equivalents. Any anti-inflammatory agent and / or topical corticosteroid may be used in the compositions of the present invention. In other embodiments, anti-inflammatory agents and / or topical corticosteroids are omitted.

Furthermore, in other embodiments, the composition comprises one or more antifungal agents. Preferably, the antifungal agent is nystatin; rotrimazole; fluconazole; ketoconazole; itraconazole; rotrimin; canesten; mycosporin; empeside (mycelex); clotrimazole; mycosporin; empeside; clotrimazole and the like. And their equivalents.

Furthermore, in other embodiments, the composition further comprises para-aminobenzoic acid (PABA), PABA esters (glyceryl PABA, amyldimethyl PABA and octyldimethyl PABA), butyl PABA, ethyl PABA, ethyldihydroxypropyl PABA, benzophenone (). Oxybenzon, slysobenzon, benzophenone and benzophenone-1-12), avobenzon, cinnamate (and octylmethoxycinnamate, isoamyl p-methoxycinnamate, octylmethoxycinnamate, sinoxate, diisopropylmethylcinnamate, DEA-methoxycinnamate, ethyl Diisopropyl cinnamate, glyceryl octaate dimethoxy cinnamate and ethyl methoxy cinnamate), cinnamic acid ester, salicylic acid ester (hommentyl salicylate, benzyl salicylate, glycol salicylate, isopropylbenzyl salicylate, etc.), trolamine salicylate, anthranyl acid ester, ethyl urocanate, Homosalate, dibenzoylmethane derivatives (eg, avobenzon), octoclylen, methylbenzilidencanfer, etc. are traded in Mexico XL®, Tinosorb S®, Tinosorb A2B®, NeoHelipan®, Mexoryl XL. It may also contain a sunscreen or UV blocker, such as Registered Trademarks), Uvinul T®, Parsol SLX®. Non-limiting examples of physical sunscreens include kaolin, talc, petrolatum and metal oxides such as titanium dioxide and zinc oxide. Skin conditioners, UV light blockers, thickeners, antioxidants, and pharmaceutical and cosmetically acceptable ingredients are published annually by McCutcheon Publishing in both North American and International editions, McCucheons Emulsifiers and Detergents. They may also be found in books such as (Vol2) Functional Materials, both of which are incorporated herein by reference in their entirety.

Also, in other embodiments, the topical composition can further include a skin conditioner or fabric softener containing plant and / or herbal ingredients that make the outer layer of the skin softer and more flexible. .. The softeners are aloe vera extract, rose oil (ie essential oils extracted from various types of roses, arnica extract, chamomile extract; chamomile flower extract; cetearyl alcohol; isopropyl myristate; triglyceride; myristic acid; palmitic acid; PEG- 60 Hydrogenated castor oil; glyceryl linoleate; cyclomethicone; dimethicone; decyl oleate; steaic acid; lanolin; vegetable oil; shea butter; cocoa butter; algae extract; avocado oil; seed oil; Himashi oil; chamomile oil; lemongrass extract; lime oil; malla oil; olive oil; pantenol; corn oil; flaxseed oil; carrot extract; hashbami oil; pomegranate seed oil; rice oil; ginger, etc., and mixtures thereof. In other embodiments, the topical composition is a vitamin such as Vitamin A, B, C, E, β-carotene; Vitamin B complex; Vitamin B12, antioxidant, sodium, potassium, It may contain minerals such as calcium. In other embodiments, the vitamin or mineral may be omitted.

Non-limiting examples of antioxidants that can be used with the compositions of the invention are acetylcysteine, ascobic acid polypeptide, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascorbyl stearate, BHA. , BHT, t-butylhydroquinone, cysteine, cysteine HCl, diamilhydroquinone, di-t-butylhydroquinone, disetylthiodipropionate, dioleyltcopherylmethylsilanol, disodium ascorbyl sulfate, distearyl thiodipropionate, Ditridecyl thiodipropionate, dodecyl eodic acid, erythorbic acid, ester of ascorbic acid, ethyl ferulate, ferulic acid, eodic acid ester, hydroquinone, isooctyl thioglycolate, oxalic acid, magnesium ascorbate, magnesium ascorbyl phosphate, ascorbic acid Natural plant antioxidants such as methylsilanol, green tea or grape seed extract, nordihydroguaiyaretinic acid, octyl eosinate, phenylthioglycolic acid, potassium ascorbite copheryl phosphate, potassium sulfite, propyl phosphite, quinone, rosmarin Acid, sodium ascorbate, sodium hydrogen sulfite, sodium erythorbate, sodium pyrosulfate, sodium sulfite, superoxide dismutase, sodium thioglycolate, sorbitylfurfural, thiodiglycol, thiodiglycolamide, thiodiglycolic acid, thioglycol Acid, thiolactic acid, thiosalicylic acid, tocopheres-5, tocopheres-10, tocopheres-12, tocopheres-18, tocopheres-50, tocopherol, tocophersolan, tocophersolan acetate, tocopheryl linoleate, tocopheryl nicotinate, succinic acid Includes tocopheryl and tris phosphate (nonylphenyl).

Examples of preservatives are quaternary ammonium preservatives such as polyquaternium-1 and benzalkonium halides (eg, benzalkonium chloride (“BAC”) and benzalkonium bromide), parabens (eg, methylparaben). And propylparaben), phenoxyethanol, benzyl alcohol, chlorobutanol, phenol, sorbic acid, thimerosal, azole, benzisothiazolin-3-one, benzalkonium quaternary compound, benzyl alcohol, borate, 2-bromo-2- Nitro-Propane-1,3-diol, butylparaben, 5-chloro-2-methyl-4-isothiazolin-3-one, chlorphenesin, chlorxylenol, diazoridinylurea, dimethyl-benzylalkyl-ammonium chloride, ethylparaben, Formaldehyde, glutaraldehyde, halogenated salicylanilide, hexachlorophen, isobutylparaben, isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, methylparaben, mono-chloracetamide, neomycin sulfate, O-phenylphenol and its like. Includes salts, phenoxyethanol, propionic acid and its salts, propylparaben, sodium benzoate, sorbic acid and its salts, tebuconazole and triazole, or combinations thereof.

In certain embodiments, the compositions described herein can further include, but are not limited to, colorants selected from dyes or pigments. As an example, the colorant is present in an amount of (about) 0.0001% by weight to (about) 1% by weight of the composition. As another example, the colorant is present in an amount of (about) 0.0005% by weight to (about) 0.5% by weight of the composition.

The compositions for killing or repelling the pests described herein can be formulated as personal care or cosmetic compositions. For some uses, the personal care or cosmetic composition is formulated as a product selected from insect repellents, skin care products, hair care products and cleansing products. As some examples, the personal care or cosmetic composition is a skin conditioner, hand / body / facial lotion, skin moisturizer, lotion, skin disinfectant, skin cleansing composition, skin soothing and lubricating composition. , Sunscreen products, anti-aging products, sunscreen products, self-tanning products, after-sun products, masking products, and wrinkle-removing products. In other examples, the personal care or cosmetic composition is a hair conditioner, a hair styling gel, an anti-blurring composition, a hair growth-enhancing composition, a hair lotion, a hair nick, a rinse, a conditioner, a hair color composition, a hair anti. A hair care product selected from hair shaving agent compositions, hair shining compositions, mousses, styling gels, hair pomade products and hair sprays. As another example, the personal care or cosmetic composition is selected from soaps, foam bath products, hand / body / facial cleansers, convergent cleansers, anti-acne products, shampoos, body shampoos, synthetic detergents, shower gels and shampoos. It is a cleansing product.

The compositions for killing or repelling the pests described herein can be formulated as home care compositions. As some examples, the household care composition is an air deodorant / cleaning agent composition in liquid, gel or solid form, a universal cleaner composition, a universal disinfectant composition, a deodorant spray and powder, a dishwashing detergent, Cloth straightening composition, cloth softening composition, cloth electrostatic control composition, hard surface cleaning composition, hard surface cleaning agent, hard surface disinfecting composition, linen and bedding spray composition, pesticide pesticide composition, polishing composition Cleaning and disinfecting compositions for goods, laundry detergents, carpet and interior detergent compositions, cleaners and deodorants, tiles, toilets and tubs, waxes and cleaning compositions for wooden floors or furniture, and automotive waxes and It is dispensed as a product of choice from cleaning compositions. As an example, the household care product is a cloth softening composition selected from a liquid cloth softener, a cloth softening rinse, a cloth softening sheet and a cloth softening gel.

In at least one embodiment, the topical composition can include 0.01% by weight to about 99% by weight of the repellent composition. In at least one embodiment, the repellent composition can range from 0.01 wt% to 25 wt%. In one more preferred embodiment, the repellent is methyl anthranilate in the range of about 2 wt% to about 15 wt% (also may be referred to as MA herein). In a more preferred embodiment, the amount of methyl anthranilate is less than 8% and can be applied to the skin of interest in amounts up to about 5000 mg / kg.

In at least one embodiment, the topical composition comprises an organic phase and an aqueous phase. In one embodiment, the organic layer comprises a repellent and a surfactant or emulsifier optionally combined with a fatty acid. _In a more preferred embodiment, the aqueous phase comprises water, glycerin, lecithin, C1 _- C6 alcohol or a combination thereof. In another embodiment, the aqueous phase may comprise a thickener such as xanthan gum. In one embodiment, the aqueous phase may contain water in an amount of about 5 w / w% to about 50 w / w%, preferably in an amount of 40 w / w% to 45 w / w%, 0 w / w. An amount of% to about 40 w / w% may contain xanthan gum, preferably an amount in the range of 20 w / w% to 30 w / w%.

In at least one embodiment, the topical formulation is in the form of an oil-in-water emulsion containing MA, oleic acid, stearic acid, ethoxylated alcohol (eg, Rhodasur® L-9 brand), glycerin and water. Is. In at least one more preferred embodiment, the MA is in the range of about 2w / w% to about w / w8%, preferably in the range of 3.35w / w% to 6.7w / w%. In other embodiments, oleic acid is present in the range of about 0.5 w / w% to 3 w / w%, preferably 0.065 w / w% to 1.3 w / w%. In other embodiments, stearic acid can be present in the range of about 1 wt% to about 10 wt%, preferably 1.5 wt% to 4.0 wt%.

In at least one other embodiment, the topical formulation comprises diethylhexane adipate, homosalate, octocrylene, octisalate, avobenzone, bemotridinol, cyclopentasiloxane, cyclohexasiloxane, necromon and ethanol. Also, in other embodiments, the formulation is in the form of a lotion containing water and lecithin in the aqueous phase and oleic acid, methyl anthranilate and Caproyl90® in the organic phase. Also in other embodiments, the topical composition is in the form of a body spray comprising C12-C15 alkyl benzoate, triethylhexyl citrate, _isododecane , _necromon , polyamide-3 and a modified alcohol.

In at least one embodiment, the consumer care product is about 1 w / w% to about 10 w / w%; about 3 w / w% to about 7.5 w / w%; about 3.35 w / w% to about. Includes MA in an amount in the range of 6.7 w / w%. In other embodiments, oleic acid (also referred to herein as "OA") is from about 0.1 w / w% to about 2.5 w / w%, preferably from about 0.45 w / w%. It is present in an amount in the range of about 1.3 w / w%; stearic acid is in the range of about 1 w / w% to about 8 w / w%, preferably about 2.0 w / w% to about 4.0 w / w%. The ethoxylated C ₁₂ -C ₁₅ alcohol is present in an amount ranging from about 1.5 w / w% to about 12 w / w%, preferably about 3.0 w / w% to about 6 w / w%. Glycerin is present in an amount of about 2.5 w / w% to about 15 w / w%, preferably about 5 w / w%, and solvents such as water are 25 w / w% to 85 w / w%, preferably. Is present at about 75 w / w%.

Another aspect of the invention shows a method of repelling insects and / or mite pests using the anthranilic acid ester / fatty acid composition described above. Such compositions include carpenter bee (pavement ant), carpenter bee, Argentine ant, chibihi ant, ghost ant, cold tolerant ant, yama ant, Asian needle, odorus ant, rover ant. , Ants, bigheaded ants, carpenter bees, carpenter bees, carpenter bees, small carpenter bees, European paper wasps, European paper wasps, German carpenter bees (Germany) Gokiburi, including eastern underground white ants; halves including carpenter bee and carpenter bee; twins including yabuka and carpenter bee; corn rootworm, sawtoothed beetle and carpenter bee Eyes; Provides effective extermination activity against a large number of insects, including ants including carpenter bees and carpenter bees including carpenter bees. The extermination activity has also been demonstrated against brown dog ticks.

The composition of the present invention is repellent against a large number of birds including hummingbirds, rusty blackbirds, sparrows, flicker, hummingbirds, black-capped chicks, crows, wrens, starlings, northern cardinals, finch, flicker and pigeons. Does not show.

The repellent compositions of the present invention are suitable for eliminating the presence and swarm of pests even in sensitive areas such as food storage and preparation areas, kitchen floors, cabinets, drawers, dining areas and playgrounds. Its repellent composition is applied in and around buildings (houses, garages, barns, restaurants, breweries, and industrial buildings), electric boxes, gardens, farms, golf courses, trash cans, decks and courtyards, outdoors. It can be used for other applications, such as applications for repelling pests at outdoor social events such as parties, picnics, etc. The composition is on a material such as paper, cellulose or natural sponge, disposable tissue, garbage bags such as clothing, tablecloths, brace mats, camping equipment (backpacks, tents, waterproof sheets or nets) cloth. It can be applied or incorporated into a material, or it can be incorporated into a plastic such as a garbage bag or a plastic table cover. The repellent composition can be sprayed onto a bird feeder or bird feeder to repel competing pests without repelling birds.

In at least one other embodiment, the invention comprises a composition comprising at least one insect or mite repellent component comprising anthranyl acid ester and a pharmaceutically suitable topical carrier, subject in need of their repellent. Concerning methods of repelling insects from a subject, including topical administration to. In one embodiment, the subject is a mammal such as a human, dog, other livestock or live cow.

In other embodiments, the topical composition can be applied directly to the skin or the user's garment and garment. Also, in other embodiments, the insect species are carpenter bee (pavement ant), carpenter bee, Argentine ant, carpenter bee, ghost ant, cold tolerant ant, carpenter bee, Asian needle, etc. Odolus ant, rover ant, hiari, bigheaded ant, bee, carpenter bee, carpenter bee, small carpenter bee, European carpenter bee (European pea)) Carpenter bee-containing membranes; Carpenter bee-containing cockroaches, Eastern underground white ants; ) And carpenter bee including carpenter bee; including carpenter bees including ants and carpenter bees including carpenter bee and brown dog ticks.

In a preferred embodiment of the invention, a skin-applied formulation comprising a mixture of oleic acid and methyl anthranilate in various proportions described herein; of oleic acid and methyl anthranilate in various proportions described herein. Household products such as sprays containing mixtures; and household products such as clothing treatments containing mixtures of oleic acid and methyl anthranilate in various proportions described herein.

The modifier "about" is used herein to indicate that certain more preferred measurement ranges, such as molar ratios, reactants, material quantities and temperature ranges, are not fixedly determined. Its meaning will often be apparent to those skilled in the art. For example, in formulation, a description of a concentration of 200 g / L is interpreted to include other concentrations such as 180 g / L or 220 g / L that are expected to provide a more similar effect to that concentration. If instructions from the experience of one of ordinary skill in the art are missing, instructions from the context are missing, and more specific rules are not listed below, the range of "about" is the absolute value of the endpoints. It does not exceed 10% or does not exceed 10% of the stated range, whichever is smaller.

All lists used to describe the inventions disclosed herein are not limited and include other items unless otherwise stated.

Example Formulas Formula A: The following formulations were prepared to test the repellent of insects: 30 wt% oleic acid, 10 wt% methyl anthranilate and 60 wt% Sunspray 6E oil (Sunoco Oil). ) Was mixed until homogeneous. In other forms, Sunspray 6E oil can be replaced with any reasonable alternative light paraffin oil.

Formula B: The following formulations were prepared for testing insect repellent: 9 wt% oleic acid, 3 wt% methyl anthranilate and 88 wt% Sunspray 6E oil (Sunoco Oil). , Mixed until homogeneous.

Formulation C: The following formulations were prepared for testing insect repellent: 3% by weight oleic acid, 1% by weight methyl anthranilate and 96% by weight Sunspray 6E oil (Sunoco Oil). , Mixed until homogeneous.

Formula D: The formula described below was prepared to test the repellent of insects: 0.9% by weight oleic acid, 0.3% by weight methyl anthranilate and 98.8% by weight Sunspray 6E oil. (Sunoco Oil) was mixed until homogeneous.

Formulation E: The following formulations were prepared for testing insect repellent: 0.3% by weight oleic acid, 0.1% by weight methyl anthranilate and 99.6% by weight Sunspray 6E oil. (Sunoco Oil) was mixed until homogeneous.

Formulation F: The formulations described below were prepared to test insect repellent: 30% by weight oleic acid, 10% by weight methyl anthranilate, 52% by weight methyl laurate, 4% by weight Agnique. (Registered Trademark) ABS 60CB (sodium dodecylbenzene sulfonate manufactured by Cognis), 2% by weight Agnique® (registered trademark) CSD-40 (EO / PO block copolymer manufactured by Cognis) and 2% by weight Tergitol (registered trademark). Registered trademark) XD (surfactant manufactured by Dow Chemical). The components were mixed until homogeneous.

Formulation G: The formulations described below were prepared for testing insect repellent: 10% by weight oleic acid, 10% by weight methyl anthranilate, 3.2% by weight Agnique® ABS 60CB. (Calcium dodecylbenzene sulfonate from Cognis Corporation), Agnique® SMO-20 (sorbitan monooleate from Cognis Corporation), 2.47% by weight Agnique® BP4-3103 (registered trademark) from Cognis Corporation. EO / PO block copolymer), 72.89 wt% Aromatic 100 solvent. The components were mixed until homogeneous.

Formula H: The formula described below was prepared for testing insect repellent: 30% by weight oleic acid, 10% by weight methyl anthranilate, 60% by weight polyethylene glycol. The components were mixed until homogeneous.

Formula I: The formula described below was prepared for testing insect repellent: 3% by weight oleic acid, 1% by weight methyl anthranilate, 96% by weight polyethylene glycol. The components were mixed until homogeneous.

(Example 1)
Repellent of wasps, carpenter bees and ants using oleic acid and methyl anthranilate

The following formulations were prepared to test insect repellent:
1) 3% by weight of oleic acid, 1% by weight of methyl anthranilate, 96% by weight of Sunspray 6E oil (Sunoco Oil Company) (formulation I).
2) 3% by weight oleic acid, 97% by weight Sunspray 6E oil
3) 1% by weight of methyl anthranilate, 99% by weight of Sunspray 6E oil
4) 1% by weight of oleic acid, 0.3% by weight of methyl anthranilate, 98.7% by weight of Sunspray 6E oil (formulation D).
5) 1% by weight oleic acid, 99% by weight Sunspray 6E oil

Six ml of honey and two tablespoons of canned mackerel were placed on eight 6-inch paper plates as food. A dish with two baits was sprayed with 0.25 ml of Dispensing 1 (Dispensing I), two were sprayed with Dispensing 2, two were sprayed with Dispensing 3, and two were left untreated as controls. rice field. The dishes were placed 25 yards apart from each other in the woodlands of the Ewing District, New Jersey, United States. The dish was observed for 2 hours, during which time German wasps (Vespula germanica), North American carpenter bees (Vespula maculate) and ants gathered and ate from the control dish, but avoided all processed dishes. .. After 2 hours, the number of carpenter ants (Camponotus pennsylvanicus) in each dish is counted and the results are summarized in Tables 1A and 1B below. Only ants were counted, as ants tend to drive away other ants. Also, wasps and carpenter bees were not found on or near the treated dish, but they often gathered on the control dish to feed while moving away.

Oari found on a plate with food in Test 1

Oari found on a plate with food in Test 2

The% inhibition of the treated dish was calculated using the following formula:% inhibition = (ants on the control dish-ants on the treated dish / ants on the control dish) x 100. The% inhibition of each formulation is summarized in Table 2 below.

The presence of a synergistic effect between the two active ingredients is the formula of Colby (see Weeds 1967, 15, pg20-22 "Calculating synergistic and contradictory reactions of herbicide combinations" Colby SR). : Established with the assistance of E = X + Y- (XY / 100).

By using the method of Colby, the presence of a synergistic effect between the two active ingredients is by first calculating the expected activity'E' of the mixture, based on the activity of the two ingredients applied alone. Established. If'E'is lower than the observed activity, there is a synergistic effect. In the above formula,'X' is the percent control observed when oleic acid is applied in proportions of'x'. The term'Y'is a percent control observed when methyl anthranilate is applied alone in the proportion of'y'. The formula is that the expected activity'E' when the proportion'y' Y'is mixed with the proportion'x''X' if those effects are strictly added and no synergistic effect occurs. To calculate.

In Test 1, the calculated'E'value was 15%, but the actual value was 97%, an improvement of 82% over the expected additive effect. In Test 2, the value of'E'was 83%, but the actual value was 92%, a 9% improvement over the expected additive effect. Both tests show the synergistic effect obtained using oleic acid and methyl anthranilate in a ratio of 3: 1 each.

(Example 2)
Repellent of bees with oleic acid and methyl anthranilate

6 ml of honey was placed on each of the two 6-inch paper plates as food. One of the dishes on which the food was placed was sprayed with about 0.25 ml of Pharmaceutical A, and the other was untreated as a control. The dishes were placed 25 yards apart from each other in the forest area of Yardley, Pennsylvania. They were placed one foot apart from each other, about 35 yards from the hive. The dish was observed for 2 hours, during which time more than 70 bees (Apis mellifera) gathered and ate food from the control dish, but the bees did not approach the treated dish. At the lapse of 2 hours, the number of bees on each dish was counted, with 14 bees on the control and none on the treated dish.

(Example 3)
Insect repellent using a mixture of oleic acid and methyl anthranilate

One tablespoon of canned cat food was placed on two 6-inch paper plates as food. One of the dishes on which the food was placed was sprayed with 0.302 g of Formula F, and the other was untreated as a control. Honey (25 mL) was diluted with 75 mL of tap water and stirred to form a homogeneous solution of the mixture. The dishes were placed 5 yards apart from each other in the woodlands of the Ewing District, New Jersey, United States. Each dish was poured with 50 mL of diluted honey solution. The dish was observed for 2, 4 and 6 hours for insects. After 2 hours, the number of insects on each dish was counted, with 7 ants and 6 German wasps on the control dish, but none on the treated dish. After a 4-hour check, all food on the control dish was consumed, the food was replaced, and the treated dish had two ants and dead houseflies (these were removed). At 6 hours, there were 8 German wasps and 4 ants on the control dish and no insects on the test dish.

(Example 4)
Repellent of wasps using a mixture of oleic acid and methyl anthranilate

An aqueous 25% honey solution was placed on an 8-inch paper plate as food and placed on a cement block in the forest area of the Ewing District, New Jersey, United States. Four hours later, about 50 German wasps actively flew around the plate and ate from the plate on which the food was placed. When 5-8 wasps were feeding on the bait, about 5 mL of Formula F was applied as mist on the dish and in the area near the dish using a hand spray bottle. All wasps withdrew from the dish and its vicinity. A wasp died in direct contact with the spray. Many wasps approached within about 6 inches of the treated dish, but were less closely. Within 10 minutes, all the wasps left. One hour later, a wasp was flying around the plate, but did not land on or near the plate. No additional insects were observed on or near the dish after treatment.

(Example 5)
Repellent European wasp using a mixture of oleic acid and methyl anthranilate

A live European Paper wasp nest was located outside the Ewing office building in New Jersey, New Jersey, United States, with more than 70 chambers and about 10 wasps caring for the nest. Formula A is poured into a 32 ounce Zep® spray bottle equipped with a nozzle tuned to deliver fine mist, and the nest is sprayed from the spray bottle using two pumps. rice field. At the time of application, there were four wasps on the nest, which were immediately killed (these were removed from the nest). Within minutes, three wasps were observed to return to their nests, but they were exterminated and did not land on their nests, eventually giving up after several attempts to land on their nests. bottom. After 16 hours, 2 weeks and 4 weeks, the nest was still abandoned.

(Example 6)
Insect repellent using a mixture of oleic acid and methyl anthranilate

Dispensing A was poured into a plastic spray bottle and sprayed onto 20 8-inch dishes by pushing the trigger of the pump for each dish. It was found that the treated dishes weighed about 0.22 g to about 0.24 g when sprinkled on each dish. Ten treated dishes were randomly placed on the ground of a farm in Spark, Georgia, United States, and ten control (untreated) dishes were placed approximately 3 feet above the ground. Was done. Ten treated dishes are placed approximately 4 feet from the live fire ant mound, and 10 control dishes are placed near the same mound, no less than 3 feet from the treated dish. Was done. Each dish was placed with about 15 mL of an aqueous 25% honey solution. The test dish was observed for 8 hours.

Of the randomly placed treated dishes, seven had no active insects and one had two flies ((Bradisia sp, Dolichopus, all dead)). One had a wood cockroach (dead) (Parcoblatta pennslvanica), and one had a black mushroom fly (dead). The control dish had some ants and black mushroom flies. , Long-legged fly, Cyrphidea sp, Chalcidoidea sp, honeybee and cockroach. None of the insects on the control dish were dead.

Of the treated dishes placed near the mounds of live fire ants (Solenopsis invicta), the dishes were also free of insects on or near the dishes. Fifty percent of control dishes had live fire ants that ate within 15 minutes, and 100% of control dishes had live fire ants that ate within 30 minutes. There were no live fire ants feeding on any of the treated dishes for 4 hours.

In another study, honey solutions were placed on dishes treated with methyl anthranilate (about 100 mg) alone, within 4 feet of fire ant mounds, and the food on these treated dishes. Fire ants were prevented from coming to.

Many ants were found to eat food on control dishes, but on treated dishes in Examples 2, 3, 4 and 6 above and other tests similar to those above. It was confirmed that they did not eat food. Among the ants, the genera includes:
1) Tetramorium-Pavement ants 2) Camponotus-Oari 3) Wansmannia-Chibihiari 4) Konukaari (Tapinoma) -Ghost Ali 5) Nagaari (Stenamma) ) Yamaari (Formica) -Yamaari 7) Futhariari (Pachycondyla) -Asia Hariari 8) Kubileari (Dorymyrmex) -Odrasari 9) Kobitori (Brachymyrmex) -Rover Alis (10) Solenops (Pheidole) -Big Headed Ant 12) Linepitema-Argentina ants

(Example 7)
Insect repellent using a mixture of oleic acid and methyl anthranilate

A hummingbird plastic bait box was filled with a solution of hummingbird food, hung in the backyard of the house and observed for 2 hours. Seventeen bees and three hummingbirds visited the feeding box, all of which ate food from the feeding box. The bait box was sprayed with Formula A using a plastic bottle and hung again. The treated bait box was observed for 2 hours, with about 25 bees flying near the bait box in the first 30 minutes, two coming within 1 inch but not landing. After 30 minutes, the bee completely abandoned the bait box. During the two hours, four feeding hummingbirds visited and showed that the hummingbirds were unaffected by oleic acid / methyl anthranilate.

(Example 8)
Repellent of insects using a mixture of oleic acid and methyl anthranilate in a planned picnic setting

As a picnic setting, in the Ewing forest area of New Jersey, one treated and one untreated (garbage bin) 2 gallon bucket, one treated and one untreated (picnic table) Set) Paper placemats placed on a sheet of plywood placed on the ground and paper plates on the placemats, and one treated and one untreated (counterfeit trash bag) open plastic trash I prepared a bag. Formula A was sprayed inside one of the two gallon buckets. A paper cup was placed on the bottom of the bucket and 10 mL of honey diluted with 20 mL of tap water was placed on a paper plate as food. The control bucket was also fed in the same way. The paper placemat was wiped with 1 mL of Dispensing A in the range of about 12 inches to about 15 inches. The treated and contrasting placemats (untreated) were placed on top of a sheet of plywood placed on the ground, approximately 4 feet apart. The paper plate was placed in the center of each placemat, with a mixture of canned cat food and honey placed as food. Inside a 1 gallon of Ziploc® plastic storage bag, about 0.5 mL of Preparation A was sprayed and about 50 mL of a diluted aqueous 25% honey solution was added. The bag used a metal-coated hanger as a frame to hold the bag in the open position and was hung with three branches about 4 feet from the ground. Similar untreated bags were prepared as controls and placed about 10 yards apart. The site was observed for insect activity for 2 and 4 hours after setting.

※スズメバチは、ドイツスズメバチであった。 Insects 2 and 4 hours after setting up a picnic test

* The wasp was a German wasp.

The data from this test show that a mixture of oleic acid / methyl anthranilate can be used to repel insects from a picnic or outdoor social environment.

(Example 9)
Insect repellent using a mixture of oleic acid and methyl anthranilate

Two tablespoons of canned cat food and about 5 mL of honey solution were placed on a paper plate as food. The dishes were overcoated with the test formulations A, B, C, D and E by spraying two dishes for each formulation. The two dishes on which the bait was placed were left untreated as controls. The dish on which the bait was placed was placed in the Ewing Forest Area of New Jersey. Two hours later, the dish was observed due to insect activity. The observations are summarized in the table below. German wasps were attracted to the control dish, but none to the treated dish.

Summary of Oari observed on dishes with treated and untreated food

This data shows that wasps were eradicated in all proportions of oleic acid and methyl anthranilate tested, and a mixture containing 40%, 10%, 4% and 1.2% of the oleic acid / methyl anthranilate component went to the oyster. It is shown that it shows the extermination property of.

(Example 10)
Insect control using a mixture of oleic acid and methyl anthranilate

The product F (34.9 g) was sprayed on the area of 3 feet x 3 feet in which the goldenrod was in bloom. In addition, one repetitive test was performed. Two untreated areas of 3 feet x 3 feet in bloom of goldenrod were included in this test. The treated and untreated areas were observed for 1 hour after treatment and 2-3 hours after treatment. The insects observed in this test are summarized in the table below.

Summary of insects observed during or on the goldenrod in bloom

This data shows that a mixture of oleic acid and methyl anthranilate has a repellent effect when sprayed on blooming goldenrod.

(Example 11)
Bee repellent using a mixture of oleic acid and methyl anthranilate

About 5 mL of honey bait was placed on 10 paper plates. Dispensing A, B, C, D and E were diluted with tap water so that 1 part of the dispensing was 10 parts of water. The dishes on which the bait was placed were sprayed with a diluted preparation on one dish for each preparation. The treated and untreated dishes were placed on the table approximately 35 yards from the bee hive. The progress of each test was observed for a certain period of time, and the honeybees on the test plate were observed every few minutes. After each observation, the dish was repositioned to eliminate the positional effect caused by the particular dish position preferred by the bees. The lowest progress was tested first (Preparation E) and the highest progress was tested last (Preparation A). An overview of the bees on each dish is summarized in the table below.

Bees observed on a test dish with food

As can be seen from the above data, the test solution repelled bees from the dish on which the treated bait was placed.

(Example 12)
Judicial disqualification of Eastern Subterranean Termites

Termite test sites were prepared by placing clear plexiglass (approximately 8 inches x 12 inches) flat on a table (bottom of plexiglass). Three square pieces of corrugated cardboard (about 2 inches x 2 inches) were placed so that the grooves were vertical at the center of the bottom edge on the plexiglass and at each of the left and right upper edges. These cardboard pieces feed the termites during the test. 30 g of water was added to 300 g of play sand and the mixture was stirred well to fully incorporate the water. A piece of plexiglass about 1 inch wide was brought into contact with the lower edges of the corrugated cardboard pieces located on the left and right upper edges on the bottom piece of plexiglass. Wet sand was poured around every piece of cardboard. The 1 inch wide piece of plexiglass was removed, leaving a 1 inch gap. The gap was filled with 30 g of ground choke treated with 3 mL of Formula H and 3 mL of distilled water. A top piece of plexiglass was placed on its sand and chalk and cardboard, and this top piece with a 1 inch diameter hole located on the bottom piece of cardboard, and the bottom and top pieces of plexiglass were fixed together with a binder clip. .. Approximately 200 worker Eastern underground termites (Rhinotermitidae: Rhinotermitidae flavipes) were placed on cardboard through an opening in the upper piece of plexiglass. The holes were covered with a plastic Petri dish cover and lined with plexiglass. The test site was stored at ambient temperature in a loosely closed black plastic bag. Also, untreated control sites were included in the evaluation. The test and control site were tested daily for 6 days. On day 6, the untreated control site had a termite tunnel through the choke layer and all cardboard pieces had edible damage. The treated area had a termite tunnel to the treated chalk layer, but no tunnel through the chalk layer was formed; edible damage was limited to the bottom piece of corrugated cardboard. It showed a repellent effect.

(Example 13)
German cockroach repellent test

A cockroach test site was prepared by covering the top of a 12-inch wide x 20-inch long x 3-inch high polystyrene tray with a 50/50 mixture of petrolatum to prevent cockroach escape. Two sections were cut from the bottom of the cardboard egg box and turned upside down to form a cockroach shelter. One section was sprayed with the product H and placed at one end of the test site. The second section was untreated and placed opposite the test site. Three Smarties® roll cakes were placed at the center of the test site as a food source. Fifty adult male German cockroaches (Blattella germanica) were placed at the center of the test site and observed daily for 9 days. This test was repeated. The following table summarizes the observations about the more preferred shelters for cockroaches.

German cockroach repellent results

As can be seen from the above data, the German cockroach prefers untreated shelters to treated shelters, indicating repellent.

(Example 14)
Judicial disqualification of brown marmorated stink bugs

The test site was prepared by covering the upper end of a Tupperware® 6 "x 8" storage container with a 50/50 mixture of petrolatum and mineral oil to prevent stink bug escape. The peas were immersed in the pharmaceutical product F and placed at one end of the test site. Untreated peas were placed on the other end of the container. Fourteen brown marmorated stink bugs (2nd-4th instars, Pentatomidae: Halyomorpha hallys) were placed in the center of the test site. A second test site was prepared as a control by placing untreated peas on both ends of the vessel. The test site was maintained at ambient temperature for 96 days, when the stink bugs at the second test site (control) ate both peas equally, whereas the treated peas were placed. The stink bugs in the slaughtered containers were shown to be repellent as they ate only untreated peas.

(Example 15)
Judicial disqualification of Helicoverpa armigera on cotton

Four cotton plants (non-BT cotton plants with two leaves) were treated with the product F by the method of placing one drop of the drug on the upper surface of each leaf. The treated plant was placed on one side of a wire mesh cage (14 "x 14" x 14 ") of a BioQuick® product; an untreated cotton plant was placed on the other end of the cage. Repeated 4 times. 5 pregnant female Helicoverpa armigera (Geometridae helicoverpa) were introduced into each cage. 16 hours after introduction, the number of eggs placed on treated and untreated cotton foliage was counted. The table below summarizes the number of eggs in the four repeat tests.

Eggs of Helicoverpa armigera placed on cotton leaves

This data shows that plants treated with oleic acid and methyl anthranil have a repellent effect on Helicoverpa armigera when choosing a spawning site.

(Example 16)
Judicial disqualification of brown dog ticks

For the preparations H and I, the repellent test of the brown dog tick (Rhipicephalus sanguineus) was carried out by the following method.

Five strips of filter paper (1 inch x 3 inch) were each treated with 1 mL of the reagent. It was formulated and dried. Untreated filter paper pieces of the same size were stapled to the bottom of each treated piece to make the final test piece 6 inches long. The specimen was hung vertically on the tray and the bottom was the untreated area. Five additional specimens were prepared untreated as controls. Five male-female mixed dog mites were repeatedly tested. One tick at a time was introduced into the untreated portion of the test piece, allowing it to move upwards. The mites were observed for up to 1 minute to determine if they would crawl upwards across the treated filter paper. Mites that fell after stopping, rotating, or contacting the treated portion of the specimen were classified as exterminated. All 25 mites were exterminated when tested with preparations H and I. In the controlled trial, none of the mites were exterminated. These tests show that the formulations of oleic acid and methyl anthranilate are superior in repelling the brown dog tick.

(Example 17)
Yellow fever mosquito repellent

For the preparations H and I, the repellent test of yellow fever mosquito (Aedes aegipti) was carried out by the following method.

Mosquito exposure containers and membrane feed boxes were used to allow mosquitoes to select blood-filled pools of three bovine blood-covered collagen membranes. The blood was prepared by adding 26 mL of bovine blood to 72 mg of ATP disodium salt as a feeding stimulant. The blood was poured into the caps of the membrane bait box until each puddle was completely filled (meniscus slightly above the level of the puddle). A circular piece of collagen (3 cm in diameter) was placed on each puddle. One membrane was treated with 25 microliters of formulation H, one was treated with 25 microliters of formulation I, and one was untreated. The test was repeated 5 times. The bait box of the film was connected to a heated water bath and warmed to 37 ° C-40 ° C. An exposure container containing 250 female mosquitoes was placed on the feeding box, opened and the number of mosquitoes exploring the membrane covering each pool was recorded every 2 minutes for 20 minutes. A new group of female mosquitoes was used for each repeated test. The numbers were summed for each repeat test and the sum was averaged. The average value of the number on the control membrane was 65, the average value on the membrane of the pharmaceutical product H was 0, and the average value on the membrane treated with the pharmaceutical product I was 6.8. This data shows that the formulations of oleic acid and methyl anthranilate are superior in repelling yellow fever mosquitoes.

(Example 18)
Extermination of cat flea larvae The repellent test of cat flea larvae (Ctenocephalides felds) was carried out by the following method for the preparation H and its diluted solution.

The test solution of the product F was prepared by diluting the product F with polyethylene glycol. Preparation F contains 30% by weight oleic acid and 10% by weight methyl anthranilate (40% by weight total active ingredient); the first diluent gives a concentration of 12% active ingredient (formulation 18-). 1); The second diluent gives a concentration of 4% active ingredient (formulation 18-2); the third diluent gives a concentration of 1.2% active ingredient (formulation 18-3). ; And the final diluent gives a concentration of 0.4% active ingredient (formulation 18-4).

A round piece of black construction paper (150 mm in diameter) was treated with the test solution of the product H by covering half of the paper with an aluminum wheel and then spraying the test product. The treated paper was attached to the bottom of a 150 x 15 mm Petri dish. The Petri dish was dried in a laboratory fume hood for a few minutes. Ten cat flea larvae were released into the central region of the treated paper and untreated or treated parts of the test strip were observed for 2-3 hours. The observations are summarized in the table below.

Repellent cat flea larvae

This data shows that cat fleas are repelled by a low proportion of 0.4% bound active ingredient, a formulation containing oleic acid and methyl anthranilate.

(Example 19)
Repellent of Southern Corn Root Worm

Test A: The test site for A was prepared by cutting a round piece of filter paper in half and placing both halves on the bottom of a plastic Petri dish, leaving a small gap between the two halves of the filter paper. The filter paper piece was moistened with 1 mL of deionized water per side. Three germinated corn saplings were dipped in Formula F, dried and placed on one filter paper piece at one end of the Petri dish so as far as possible from the gap between the filter paper pieces. Three untreated germinated corn seedlings were placed on the other piece of filter paper, as far as possible from the gap. Eighteen second-instar Southern corn root worms (Diabrotica undecimpunctata howardi) were placed in the central line gap between the two pieces of the filter paper and a plastic petri lid was placed on top. An untreated control with three untreated germinated maize seedlings on each side was tested, and all six well-treated germinated maize seedlings were also included in the test. The Petri dish was maintained in a dark growing room at ambient temperature and humidity for 24 hours. Observations were made after 4 and 24 hours to see if the larvae ate the germinated maize seedlings. The observations are summarized in the table below.

Observation of Southern corn root worm larvae foraging

This data shows that Southern corn rootworm larvae are repelled by eating compositions containing oleic acid and methyl anthranilate.

Test B: A 50 mL of polyoxypropylene conical tube was filled with 20 mL of topsoil containing 10% water. Approximately 75 Southern corn root worm eggs (Diabrotica undecimplantata howardi) were placed in the soil. The eggs were suspended in distilled water and pipetteed to the soil. A top 10 mL final layer of soil for untreated control or treated soil for treatment test was added to the top. For the treatment test, 375 mg of Pharmaceutical F was diluted with 15 mL of distilled water. This solution was added to 150 mL of top soil and mixed thoroughly. Treatment was also included in which the treated soil was used for both the lower and upper layers. A 1-inch lettuce disc was placed on the top layer of soil as food, the tube was covered, and stored at ambient temperature and humidity for 7 days. The lettuce disc was replaced three days later. Seven days later, the larvae that hatched and spread on the lettuce disc were counted, and the larvae that hatched and remained in the soil were observed. Each test was repeated. The observations are summarized in the table below.

Observation of Southern corn root worm egg hatching and larval feeding

This data indicates that Southern corn root worm larvae are eradicated by eating a formulation containing oleic acid and methyl anthranilate, and Southern corn root worm eggs do not hatch in the presence of oleic acid and methyl anthranilate.

(Example 20)
Repellent of Oryzaephilus survivor

A round piece of black construction paper (150 mm in diameter) was treated with the test solution of the product H by covering half of the paper with an aluminum wheel and then spraying the test product. The treated paper was attached to the bottom of a 150 x 15 mm Petri dish. The Petri dish was dried in a laboratory fume hood for a few minutes. Fifty Oryzaephilus surinamensis were released into the central region of the construction paper, and untreated or treated parts of the test strip were observed for several hours. A control test was also included in which only polyethylene glycol was sprayed on one side of the construction paper. The observations are summarized in the table below.

Observation of repellent nature of killifish

The data show that a mixture of oleic acid and methyl anthranilate shows repellent to killifish.

(Example 21)
Repellent of Confused Flour Beetle

A round piece of black construction paper (150 mm in diameter) was treated with the test solution of the product H by covering half of the paper with an aluminum wheel and then spraying the test product. The treated paper was attached to the bottom of a 150 x 15 mm Petri dish. The Petri dish was dried in a laboratory fume hood for a few minutes. Fifty Confused flour beetles were released into the central region of the construction paper and untreated or treated parts of the test strip were observed for several hours. A control test was also included in which only polyethylene glycol was sprayed on one side of the construction paper. The observations are summarized in the table below.

Observation of repellentness of Confused flour beetle

The data show that a mixture of oleic acid and methyl anthranilate shows repellentness to Confused flour beetle.

(Example 22)
Judicial disqualification of small carpenter bees

Four 2-foot x 2-foot test plots were set up in a residential area swarming with a large number of small carpenter bees (Apidae: Ceratina) that burrow in the ground. Each test plot contained more than 24 small carpenter bees that made burrows. One of the test plots was treated with Pharmaceutical F, one was treated with Pharmaceutical 18-1, and one was treated with Pharmaceutical 18-2. The remaining test plots were left untreated as controls. The formulation was applied using a handheld spray bottle that sprays about 12 inches above the test image, and about 24 spray pumps per test image. The test site was observed for 8 hours to see if small carpenter bees could enter the burrows or be exterminated. This test was conducted on a warm day in May 2013. The table below is a summary of the observations.

Observation of small carpenter bee repellent

After 28 hours, no bees were observed near the treated area. This data shows that a mixture of oleic acid and methyl anthranilate shows repellent to small carpenter bees.

In addition to the insects mentioned in the previous examples, the following insects are repelled by a mixture of oleic acid and methyl anthranilate (group, genus):
Flies, Cellar Xylocopa and Maruhanabachi (Apidae Bombus); Anti-wings, Cellar spiders (Cimicidae Cimex); Diptera, Cellar spiders (Culicidae Anepholees) Drosophila, Phoridae Megaselia; Flies, Phoridae Plodia; Spiders, Widow spiders (Therididae Latrodectus), Sicariidae (Sicariidae) , Nekobu nematode (Meloidogynidae Meloidogynae)

(Example 23)
Evaluation of bird repellent activity

Bird repellent activity was tested by treating black oil sunflower seeds with Formula F diluted with 50% deionized water. Treatment 1 prepares black oil sunflower seeds by coating them with a 10 mL diluted formulation per kg of seeds, and treatment 2 coats black oil sunflower seeds with a 50 mL diluted formulation per 1 kg of seeds. Prepared by Four 20x20 wooden trays are suspended from the bird feeder cross brackets of the Duncraft® squirrel stopper system so that 75 g of treated seeds use only two trays (only treated seeds are used). Placed on the designated), 75 g of untreated seeds were placed on the remaining two trays as controls. Those trays were observed daily to feed the birds by seeds. At a later date, the remaining seeds were collected for weighing and replaced with new seeds. The tray position was moved by one position each time it was refilled to eliminate the position effects caused by birds that prefer a particular position in the bait box to other positions. The test was performed for 2 weeks per treatment and repeated 4 times per treatment. There was no statistical difference between the amount of treated seeds consumed and the amount of untreated seeds consumed. Birds observed eating seeds were the lizard, the house finch, the golden sardine, the downy woodpecker, the downy woodpecker, the red-bellied woodpecker, the red-bellied woodpecker, the blue-bellied woodpecker, the Carolina chickadee, the tufted titmouse, the chickadee, the grackle, and the grackle. Includes butterfly and chickadee.

(Example 24)
Yellow fever mosquito repellent

A mixture of 3 g oleic acid, 1 g methyl anthranilate and 96 g isopropyl alcohol was stirred until homogeneous. This formulation is ex. Labeled as 24. Also, for comparison, a 5% solution of N, N-diethyl-3-methylbenzamide in isopropyl alcohol (the active ingredient in the DEET insect repellent) was tested. This sample was labeled with 5% DEET. Also, isopropyl alcohol (IPA), water and untreated collagen membranes were tested.

In vitro laboratory tests were conducted to evaluate the extermination of the aged test product at various intervals against female Aedes aegypti. Aedes aegypti, 250 female adult mosquitoes, were used per repeat (5 repeats per test). Adult mosquitoes were 6 days old and did not ingest the sucrose solution for about 18 hours prior to the test. An exposure vessel was used to make mosquitoes select a pool filled with five bloods covered with a collagen membrane. The collagen membrane was treated by pipetting 25 μL of the test product or solvent on a suitable membrane and spreading it evenly at the tip of the pipette.

The exposure vessel used was a 30.5 cm x 30.5 cm x 30.5 cm rigid plastic frame supported by four 4 cm high legs, with a sleeve compartment on one side and a sliding door on the bottom. rice field.

The membrane bait box consists of five pools (3 cm in diameter x 8 mm in depth) lined up on a hollow plastic block (6 cm in width x 22 cm in length x 3 cm in depth), and a sliding door at the bottom of the exposed container. Fits through. Hose attached to each side of the block circulates hot water pumped from the water bath. Sliding doors at the bottom of the exposure vessel do not cover or cover the membrane bait box pool, allowing mosquitoes to access the pool.

The membrane bait box was connected to a heated water bath, hot water was passed through the bait box via a circulation pump, and the pool was warmed to 89-95 ° F. 72 mg of ATP (disodium salt) was added to 26 mL of warm bovine citrate blood and poured into the puddle until completely filled. Collagen membranes were treated and aged as described above and then placed on each pool to completely cover the blood. Care was taken to remove all air bubbles between the membrane and the blood surface.

Mosquitoes were released into the exposure vessel shortly before exposure to the membrane. After 5 minutes, the exposed container was placed on a membrane feeding box and the sliding door was opened to allow access to the mosquito pool. The number of mosquitoes exploring each membrane was recorded every 2 minutes for 20 minutes.

The above procedure was repeated until 5 iterations were completed. A new group of 250 female mosquitoes and fresh blood were used on each iteration and the pool was washed during the iterations. The positions of the treatments were rotated on each iteration and each treatment was tested for each of the five agglomerates.

The data of the 5 repeated tests are shown below.

The above results show that the compositions of the present invention provide better repellent than DEET.

(Example 25)
The aesthetically pleasing and cosmetically acceptable skin care product J was prepared in the form of a lotion according to the following method.

First, the following components heated to 60 ° C. (beyond the melting point of stearic acid) were mixed and stirred to prepare an oil phase.
% W / w
Methyl anthranilate (MA) 6.7
Oleic acid (OA) 1.3
Stearic acid 2.0
RhodasurfL-9 3.0

Then, an aqueous phase was prepared by mixing the following components heated to 60 ° C. RhodasurfL-9 is the Rhodia brand of ethoxylated C12-C15 alcohols. Surfactants from other vendors are also acceptable.
% W / w
Water 75.0
Glycerin 5.0

Once both phases were prepared and heated to 60 ° C., they were sheared and bonded until an emulsified lotion was formed. More gradual stirring was started and the product was cooled to 25 ° C. The formulation of the formed lotion was stable at 25 ° C.

(Example 26)
Formulas K and L were prepared by the following method.

These formulations were prepared by formulating the aqueous phase and the oil phase separately. The aqueous phase was prepared by dissolving lecithin in water and heating at 80 ° C. Subsequently, the organic phase was prepared by dissolving OA and FA in Capryl90® (propylene glycol monocaprylate type II NF) and heating to 80 ° C. Under high shear, the organic phase was added to the aqueous phase and the high shear was continued until the particle size reached 3 microns. The heating was then stopped, gentle stirring was started and continued until the lotion reached 25 ° C. at which point the product was packaged and tested for efficacy against biting pests.

Preliminary toxicity studies outline beneficial eye, dermatological, and oral toxicity. The efficacy of the lotion preparation has been evaluated, and the favorable results are shown below.

そのローションは、２０％Ｄｅｅｔと比較して、効能及び毒性の概要の両方で優れていた。

The lotion was superior in both efficacy and toxicity overview compared to 20% Deet.

(Example 27)
Additional skin care formulations M, N, O of the body spray containing the prepared extermination mixture were prepared to contain the ingredients listed below.

These formulations may include sunscreens to protect the subject from harmful sun rays as well as from insect attack. Preferably, these additional formulations are clear, low viscosity body sprays.

In the preparation of the pharmaceutical product M, the A phase, the B phase and the C phase were prepared separately. Phase A was heated to 80 ° C. until all components were dissolved. Then, the A phase was cooled to room temperature, the B phase was mixed, and the C phase was mixed while stirring. In addition, these examples define formulations of the Nechromone manufacturing use product (or MUP) in all cases defined in the examples of 4 parts methyl anthranilate plus 1 part oleic acid. do.

In the preparation of the pharmaceutical product N, the A phase and the B phase were prepared separately. Then, the phase A was heated to 80 ° C. until all the components were dissolved. Then, the phase A was cooled to room temperature, and the phase B was mixed while stirring.

In the preparation of the pharmaceutical product O, the A phase and the B phase were prepared separately. Then, the phase A was heated to 80 ° C. until all the components were dissolved. Then, the phase A was cooled to room temperature, and the phase B was mixed while stirring.

(Example 28)
A female adult Aedes aegypti, i2LResearch USA, Inc. Obtained from an in-house colony. 250 mosquitoes were used per repeat (5 repeats per test). Adult mosquitoes were 5-12 days old and did not ingest the sucrose solution for about 18 hours prior to the test.

The following test materials were evaluated.

The test material was prepared by pipetting 25 μL of the appropriate material on the membrane and treated by spreading it evenly at the tip of the pipette.

The exposure vessel was a 30.5 cm x 30.5 cm x 30.5 cm rigid plastic frame supported by four 4 cm high legs, with a sleeve compartment on one side and a sliding door on the bottom.

Membrane bait boxes are five pools (3 cm in diameter x 8 mm in depth) lined up on a hollow plastic block (6 cm wide x 22 cm long x 3 cm deep) through a sliding door at the bottom of the exposed container. It fits. Hose attached to each side of the block circulates hot water pumped from the water bath. Sliding doors at the bottom of the exposure vessel do not cover or cover the membrane bait box pool, allowing mosquitoes to access the pool.

Test placement. The membrane bait box was connected to a heated water bath, hot water was passed through the bait box via a circulation pump, and the pool was warmed to 89-95 ° F. 72 mg of ATP (disodium salt) was added to 26 mL of warm bovine citrate blood and poured into the puddle until completely filled.

The collagen membrane was briefly immersed in tap water, soaked with a paper towel and laid flat on a metal tray covered with waxed paper (using vacuum grease as a temporary adhesive around the edges of the membrane). .. The membrane was then treated as described above and left to age on a heating pad at 93-96 ° F for 2 hours. Additional membranes were prepared in the same way, except that they were not treated for use as a negative control. After a ripening interval of 2 hours, the membrane was placed on each puddle (using vacuum grease as an adhesive) to completely cover the blood. Care was taken to remove all air bubbles between the membrane and the blood surface.

Exposure to mosquitoes. Mosquitoes were released into the exposure vessel shortly before exposure to the membrane. The exposure container was then placed on a membrane bait box and a sliding door was opened to allow access to the mosquito pool. The number of mosquitoes exploring each membrane was recorded every 2 minutes for 20 minutes.

The above procedure was repeated until 5 iterations were completed. A new group of 250 female mosquitoes and fresh blood were used on each iteration and the pool was washed during the iterations. The positions of the treatments were rotated on each iteration and each treatment was tested for each of the five agglomerates.

A total of three tests were performed to evaluate the application of the four formulations combined with each other to the untreated membrane. Each formulation was evaluated twice throughout the schedule of its three test days.

Statistical analysis. For percentage extermination, the total value of the mosquitoes being searched for was calculated for each iteration using the following equation: extermination = ((CT) / T) x 100, C = untreated The total value of mosquitoes that searched for pools, and T = the total value of mosquitoes that searched for treated pools.

Disinfection and standard error at an average percentage were calculated over all 5 iterations.

２時間熟成させた後の大人のメスのネッタイシマカに、６つの実験製剤を晒した場合の駆除性（未処理のものと比較した場合の百分率での駆除性）

Extermination property when 6 experimental formulations are exposed to adult female Aedes aegypti after aging for 2 hours (percentage extermination property when compared with untreated one)

(Example 28)
In an in vitro laboratory test, the extermination of mosquitoes was evaluated for females of three experimental formulations (formulation J, formulation K and formulation L) aged for 2 hours and / or 6 hours after application. The test was conducted over 3 test days: 2 days to evaluate the aging interval of 2 hours, and 1 day to evaluate the aging interval of 6 hours. Also, two positive controls (20% DEET and Off! Botanicals® pesticide) and untreated (negative) controls were evaluated for comparative purposes on each test day.

The test material was applied to a collagen membrane and aged on a heating pad for an appropriate amount of time. The membrane was then placed on a heated blood-filled puddle and exposed to mosquitoes. The number of mosquitoes exploring each pool was recorded at 2-minute intervals for up to 20 minutes.

Aedes aegypti results: The treated Formula F and Formula L each showed consistently high extermination properties over both time intervals (99.4-100% and 100%, respectively). The product J showed significantly lower extermination property than most other treatments at the aging interval of 2 hours (66.4-70.1%). The results are summarized in Table 20 below.

２時間及び／又は６時間熟成させた後の大人のメスのネッタイシマカに、３つの実験製剤及び２つのポジティブコントロールを晒した場合の駆除性（平均の百分率及び標準誤差，ｎ＝５）。百分率の駆除性は未処理の対照と比較して計算された。※製剤は試験されなかった。

Extermination when exposed to 3 experimental formulations and 2 positive controls on adult female Aedes aegypti after aging for 2 and / or 6 hours (mean percentage and standard error, n = 5). Percentage disinfection was calculated in comparison to untreated controls. * The product was not tested.

Results of Anopheles quadrimaculatus:
The treated formulations K and L each provide satisfactory extermination over both time intervals (83.6-95.8% and 87.7-91.4%, respectively) and at both aging intervals. 20% DEET and Off in 2 hours! It showed the same efficacy as the Botanicals® pesticide. At 6 hours, the experimental product gave superior efficacy compared to 20% DEET (75%). The results are summarized in Table 21 below.

２時間及び／又は６時間熟成させた後の大人のメスのハマダラカに、２つの実験製剤及び２つのポジティブコントロールを晒した場合の駆除性（平均の百分率及び標準誤差，ｎ＝５）。百分率の駆除性は未処理の対照と比較して計算された。

Extermination when exposed to two experimental formulations and two positive controls on adult female Anopheles mosquitoes after aging for 2 and / or 6 hours (mean percentage and standard error, n = 5). Percentage disinfection was calculated in comparison to untreated controls.

Culex quinquefa result:
The treated formulations K and L each consistently provide high extermination properties over both time intervals (96.9-100% and 99.5-100%, respectively) and 20% DEET and Off! It showed the same efficacy as the Botanicals® pesticide. The results are summarized in Table 22 below.

２時間及び／又は６時間熟成させた後の大人のメスのネッタイイエカに、２つの実験製剤及び２つのポジティブコントロールを晒した場合の駆除性（平均の百分率及び標準誤差，ｎ＝５）。百分率の駆除性は未処理の対照と比較して計算された。

Extermination when exposed to two experimental formulations and two positive controls on adult female Culex quinquefatus after aging for 2 and / or 6 hours (mean percentage and standard error, n = 5). Percentage disinfection was calculated in comparison to untreated controls.

In conclusion, the treated preparations K and L were effective in repelling mosquitoes even after aging for 6 hours.

The above should be considered as an example of the principles of the invention. Moreover, it is not desirable to limit the invention to the precise composition of the components and materials described herein, as numerous modifications and modifications can easily occur to those of skill in the art, and as appropriate, all suitable modifications and modifications. Equality is included in the scope of the invention described in the claims.

(Additional note)
(Appendix 1)
(A) The first active ingredient selected from the group consisting of dimethyl anthranilate, menthyl anthranilate, ethyl anthranilate, phenylethyl anthranilate and methyl anthranilate.
(B) Fatty acid,
(C) At least one additional active ingredient, and (d) carrier, as required.
Including
The ratio of the first active ingredient to the fatty acid is from about 4: 1 to about 5: 1.
Insect or tick repellent composition.

(Appendix 2)
The fatty acid is selected from the group consisting of oleic acid, ricinoleic acid, linoleic acid, palmitic acid, stearic acid and any mixture thereof.
The composition according to Appendix 1.

(Appendix 3)
The fatty acid is oleic acid,
The composition according to Appendix 1.

(Appendix 4)
The anthranilic acid ester is methyl anthranilate,
The composition according to Appendix 1.

(Appendix 5)
The fatty acid is oleic acid and the anthranilate ester is methyl anthranilate.
The composition according to Appendix 1.

(Appendix 6)
Surface active agents, emulsifiers, pH adjusters, thickeners, antioxidants, preservatives, skin conditioners, emollients, moisturizers, silicone parts, anti-inflammatory agents, sunscreens, local anesthetics, vitamins, itching Further comprising an additional compound selected from the group consisting of anesthetics, antibiotics, antifungal agents, preservatives, vasoconstrictors and any mixture thereof.
The composition according to Appendix 1.

(Appendix 7)
The emulsifier includes polysaccharide ether, polyglycoside, fatty acid, fatty alcohol, amine oxide, water-soluble cellulose, alkyl sulfonate, ethoxylated alkylphenol, alkanolamide, betaine, amphoteric ion surfactant, carboxylated alcohol, carboxylic acid, and ethoxylated. C ₁₂ -C ₁₅ Selected from the group consisting of alcohols, polysorbates, behentrimonium metosulfates, isopropylmillistates, ethoxylated sesame oils and any mixtures thereof.
The composition according to Appendix 6.

(Appendix 8)
The thickener is selected from the group consisting of carboxylic acid polymers, acrylic acid crosslinked with allyl ether of sucrose, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, gums and any mixture thereof.
The composition according to Appendix 6.

(Appendix 9)
The polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium sulfate cellulose, chitosan and any of them. Selected from the group of mixtures,
The composition according to Appendix 8.

(Appendix 10)
The gums are carrageenan calcium, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectrite, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, cararagin potassium, sucre. Selected from the group consisting of locust gum, carrageenan sodium, tragacanto gum, kitasan gum and any mixture thereof.
The composition according to Appendix 8.

(Appendix 11)
The carrier is a pharmaceutically suitable topical carrier and comprises water, glycerin, lecithin, fatty acids or any combination thereof.
The composition according to Appendix 1.

(Appendix 12)
The fatty acid is selected from the group consisting of oleic acid, ricinoleic acid, linoleic acid, palmitic acid, stearic acid and any mixture thereof.
The composition according to Appendix 11.

(Appendix 13)
The sunscreens include PABA, PABA ester, butyl PABA, ethyl PABA, ethyldihydroxypropyl PABA, benzophenone, avobenzone, silicate ester, anthranyl salicylate, ethylurocanin, homosalate, dibenzoylmethane, octocrylene, methylbenzidene camphor, kaolin, Selected from the group consisting of talc, vaseline, metal oxides and any mixture thereof,
The composition according to Appendix 6.

(Appendix 14)
The composition according to Appendix 1 comprises topically administering to a subject in need of insect repellent.
How to repel insects from the subject.

(Appendix 15)
The subject is a mammal,
The method according to Appendix 14.

(Appendix 16)
The subject is a human,
The method according to Appendix 14.

(Appendix 17)
The subject is a domestic animal,
The method according to Appendix 14.

(Appendix 18)
The composition is applied directly to the skin, the garment of interest and / or the garment.
The method according to Appendix 15.

(Appendix 19)
Contains the composition according to Appendix 1,
The ratio of the first active ingredient to the fatty acid is about 5: 1.
Consumer care products.

(Appendix 20)
A wet tissue product comprising a woven or non-woven fabric or a cellulose substrate and the composition according to Appendix 1.

(Appendix 21)
It comprises supplying the composition according to Appendix 1 and applying the composition to an insect or pest, whereby the insect or pest is killed.
The amount applied is sufficient to kill the insect or pest.
How to kill insects or pests.

(Appendix 22)
Including placing the composition according to Appendix 1 on clothing or bedding.
Thereby, when the insect comes into contact with the composition or the vapor from the composition, the insect is exterminated.
The composition is
Topically applying the composition to clothing or bedding articles, or
Washing said article of clothing or bedding with detergent and / or cloth softener containing said composition, or
Drying the article of clothing or bedding with a fabric softener containing the composition,
Placed by,
How to repel insects or mites from clothing or bedding.

(Appendix 23)
Containing the placement of the insect repellent composition according to Appendix 1, thereby repelling the insect or tick when it comes into contact with the composition or vapor from the composition.
How to repel insects or mites.

(Appendix 24)
The ratio of the first active ingredient to the fatty acid is about 5: 1.
The method according to Appendix 23.

(Appendix 25)
The composition is
Topically applying the composition to human clothing articles, human skin or hair, or animal skin or hair, or
Washing human clothing articles with detergents and / or fabric softeners containing said compositions, or
Drying an article of human clothing with a fabric softener containing the composition, or
Applying the composition to bedding, bedboards, bed slats, mattresses, box springs, furniture, carpets, baseboards or flooring or a combination thereof, or
Spraying the composition onto the surface of bedding, bedboards, bed slats, mattresses, box springs, furniture or rugs, or
Injecting the composition into a mattress, box spring, furniture or rug or a combination thereof, or
In the vicinity of the bedboard, bed slats, mattresses, box springs, furniture or carpet so that steam from the composition comes into contact with the surface of the bedboard, bed slats, mattresses, box springs, furniture or carpets. Placing an absorbent substrate or gel containing objects, or
Injecting the composition into a wall space,
Placed by,
The method according to Appendix 23.

(Appendix 26)
The composition is formulated as a personal care or cosmetic composition.
The composition according to Appendix 1.

(Appendix 27)
The personal care or cosmetic composition is formulated as a product selected from insect repellents, skin care products, hair care products and cleansing products.
The composition according to Appendix 26.

(Appendix 28)
The composition according to Appendix 1, which is formulated as a household care composition.

(Appendix 29)
Air deodorant / cleaning agent composition in liquid, gel or solid form, general purpose cleaner composition, general purpose disinfection composition, deodorant spray and powder, dishwashing detergent, cloth sizing composition, cloth softening composition, cloth electrostatic control Compositions, hard surface cleaning compositions, hard surface cleaning agents, hard surface disinfecting compositions, linen and bedding spray compositions, agricultural insecticide compositions, polishing compositions, laundry detergents, carpets and interior shampoo compositions. , Cleaners and deodorants, cleaning and disinfecting compositions for tiles, toilets and tubs, wax and cleaning compositions for treating wooden floors or furniture, and products selected from wax and cleaning compositions for automobiles. Prescribed as,
The composition according to Appendix 28.

(Appendix 30)
A cloth softening composition selected from liquid cloth softeners, cloth softening rinses, cloth softening sheets and cloth softening gels.
The composition according to Appendix 1.

(Appendix 31)
A cloth-treated sheet containing the composition according to Appendix 1.

(Appendix 32)
Including placing the composition according to Appendix 1 on the structure.
A method of treating structures infested with insects or mites.

(Appendix 33)
(A) Methyl anthranilate,
(B) Oleic acid,
(C) At least one additional active ingredient, and (d) carrier, as required.
Including
The ratio of the methyl anthranilate to the oleic acid is from about 1:10 to about 20: 1.
Insect or tick repellent composition.

(Appendix 34)
The ratio of the methyl anthranilate to the oleic acid is from about 4: 1 to about 5: 1.
The composition according to Appendix 33.

Claims (1)

(A) The first active ingredient selected from the group consisting of dimethyl anthranilate, menthyl anthranilate, ethyl anthranilate, phenylethyl anthranilate and methyl anthranilate.
(B) Fatty acid,
(C) At least one additional active ingredient, and (d) carrier, as required.
Including
The ratio of the first active ingredient to the fatty acid is from about 4: 1 to about 5: 1.
Insect or tick repellent composition.