JP6326382B2 - Flying pest repellent - Google Patents

Description

  The present invention relates to a flying insect repellent containing a component having a flying insect repellent effect.

  Flying insect repellent eliminates flying insects from the space or prevents invasion of flying insects into the space by volatilizing a component (active ingredient) having a flying insect repellent effect in the space such as the living room For example, a flying insect repellent containing a sublimable insecticidal component such as p-dichlorobenzene or naphthalene, or a room temperature volatile pyrethroid insecticidal component such as empentrin or profluthrin as an active ingredient is commercially available.

  In recent years, a search for a new substance exhibiting a flying insect repellent effect has been conducted, and for example, a flying insect repellent containing a fragrance component has been developed (see, for example, Patent Document 1). The flying insect repellent of Patent Document 1 contains an acetic ester compound (for example, p-tert-butylcyclohexyl acetate) or a monoterpene alcohol (for example, terpineol) as an active ingredient.

JP 2013-230990 A

  Since the flying insect repellent of Patent Document 1 contains substantially no insecticidal component, it has a relatively high safety against human livestock, but has a problem that the sustainability of the repellent effect is slightly inferior. In order to sufficiently exhibit the repellent effect of the fragrance component, it is necessary to use a component that maintains the repellent effect. For this reason, the flying insect repellent of Patent Document 1 contains a repellent effect continuous component such as glycol. Has been.

  However, when blending other components other than the active ingredient in the flying insect repellent, it is necessary to find an optimum blending ratio between the active ingredient and the other ingredients, which takes time and effort to prepare the product. Moreover, since an active ingredient will be diluted with another component, the original repellent effect of an active ingredient may be weakened.

  The present invention has been made in view of the above problems, searching for a component that can exhibit a sufficient flying insect repellent effect even when used alone, and a novel and useful flight using such a component. The object is to provide a pest repellent.

The characteristic configuration of the flying insect repellent according to the present invention for solving the above problems is as follows:
It is to contain a cyclic compound having antibacterial properties.

In the flying pest repellent according to the present invention,
The cyclic compound is preferably an active ingredient that exhibits a flying insect repellent effect.

In the flying pest repellent according to the present invention,
The cyclic compound is preferably a phenol compound.

In the flying pest repellent according to the present invention,
The phenolic compound is preferably at least one selected from the group consisting of 3-methyl-4-isopropylphenol, thymol, and orthophenylphenol.

In the flying pest repellent according to the present invention,
The cyclic compound is preferably hinokitiol.

  According to the present invention, an antibacterial cyclic compound (3-methyl-4-isopropylphenol, thymol, and orthophenylphenol, and hinokitiol, which are phenolic compounds) contained in the flying insect repellent is used alone. Since a sufficient flying insect repellent effect can be exhibited, a novel and useful flying insect repellent can be prepared by using the cyclic compound as one component or an active ingredient. In addition, since the flying insect repellent of the present invention does not necessarily contain other components such as a repellent effect sustained component, preparation of the product becomes easy. Furthermore, since it is not influenced by other components, the flying insect repellent effect is also stable.

  Since the cyclic compound having antibacterial properties contained in the flying insect repellent of the present invention has volatility at room temperature, it can be evaporated to obtain the flying insect repellent effect. It has been found that when the flying pests come into contact, a flying pest repellent effect equivalent to or better than that obtained when transpiration is obtained. Therefore, the flying pest repellent of the present invention is effective for use in human bodies, pets, livestock and other animals, clothing and daily necessities, and various articles such as various types of window glass in which flying pests are easily moored.

  Hereinafter, the flying insect repellent of the present invention will be described. However, the present invention is not intended to be limited to the embodiments described below.

<Cyclic compounds having antibacterial properties>
The present invention is based on the fact that “cyclic compounds having antibacterial properties” (hereinafter simply referred to as “cyclic compounds”), which have been used as antibacterial agents, show repellent effects against flying insects. The inventors of the present invention have newly discovered and conceived of utilizing this as an ingredient of a flying insect repellent, preferably as an active ingredient. The details will be described in the examples below, but when a cyclic compound is applied to a treatment target with a predetermined formulation, the effect of preventing flying pests from approaching the treatment target, or there is a flying pest on the treatment target. In this case, the effect of dissipating the flying pest was combined (the “flying pest repellent effect”). Examples of flying insects that can be repelled include mosquitoes such as mosquitoes, chikaeka, and mosquitoes, moths, chironomids, flies, flies, butterflies, moths, and bees.

  Examples of the cyclic compound exhibiting a flying insect repellent effect include phenolic compounds containing phenol in the chemical structure. Here, among the phenolic compounds, in particular, 3-methyl-4-isopropylphenol, thymol, and orthophenylphenol were found to exhibit an excellent repellent effect against flying pests.

[3-Methyl-4-isopropylphenol]
3-Methyl-4-isopropylphenol is a six-membered cyclic compound having the chemical structure (I) below.

  In normal use, 3-methyl-4-isopropylphenol is blended in cosmetics and the like as an antibacterial agent for skin, for example. 3-Methyl-4-isopropylphenol has antifungal activity (antifungal property) in addition to antibacterial properties.

[Timor]
Thymol is a six-membered cyclic compound having the following chemical structure (II).

  For example, thymol is a monocyclic monoterpene-based compound contained in the periwinkle plant, Tachytrum, and is used, for example, as an antibacterial agent or antiseptic in a normal use. Thymol is an isomer of 3-methyl-4-isopropylphenol.

[Orthophenylphenol]
Orthophenylphenol is a six-membered cyclic compound having the following chemical structure (III).

  Orthophenylphenol is used in imported citrus fruits as antibacterial agents and fungicides in normal applications, and is a substance handled as a food additive in Japan.

  Furthermore, as a cyclic compound showing a flying insect repellent effect, it has been found that hinokitiol has an excellent repellent effect against flying insects in addition to the above-mentioned phenolic compounds.

[Hinokithiol]
Hinokitiol is a seven-membered cyclic compound having the following chemical structure (IV).

  Hinokitiol is a substance contained in, for example, Aomori Hiba and Taiwan Hinoki, and is usually blended in cosmetics, food additives, and the like as antibacterial agents and anti-inflammatory agents in normal applications.

  The above-mentioned 6-membered cyclic compound 3-methyl-4-isopropylphenol, thymol, or orthophenylphenol, or the 7-membered cyclic compound hinokitiol is very useful as a novel component in flying insect repellents. It is a useful substance. When these cyclic compounds are used as a component or active ingredient of a flying insect repellent, a sufficient flying insect repellent effect can be obtained even with the cyclic compound alone without blending other ingredients such as a repellent effect sustaining ingredient. It will be. This is common in that 3-methyl-4-isopropylphenol, thymol, orthophenylphenol, and hinokitiol have a chemical structure in which an OH group is bonded to an aromatic ring (six-membered ring or seven-membered ring). It is speculated that such a specific chemical structure exhibits a new repellent effect against flying insects. As the cyclic compound, at least one selected from the above-mentioned cyclic compounds is used. That is, it is also possible to use a mixture of two or more cyclic compounds.

<Preparation of flying insect repellent>
The flying insect repellent of the present invention uses the above-mentioned cyclic compound as it is, or appropriately adds excipients, binders, etc. to the cyclic compound, and forms solid dosage forms such as powders, powders, granules, tablets, etc. However, in consideration of ease of use, it is preferable to dissolve the cyclic compound in a solvent to obtain a liquid agent. In this case, for example, it can be processed into a product form such as aerosol, pump spray, or gel. Moreover, it can also be set as the sheet | seat type product which impregnated the liquid agent in the fabric or the absorbent sheet.

  Solvents that can be used to prepare the liquid include ketone solvents such as acetone, methyl ethyl ketone, diethyl ketone, and cyclohexanone, alcohol solvents such as methanol, ethanol, butanol, propanol, and isopropanol, ethylene glycol, diethylene glycol, triethylene glycol, and propylene. Glycol solvents such as glycol, 1,3-butylene glycol, dipropylene glycol, glycol ether solvents such as diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether, toluene, xylene, normal hexane, n-paraffin, isoparaffin Hydrocarbon solvents such as ester solvents such as ethyl acetate, butyl acetate, amyl acetate, ethyl lactate, etc. And the like. When the solvent is water-soluble, an appropriate amount of water can be mixed.

  The concentration of the cyclic compound in the flying insect repellent (solution) is adjusted to 0.01% by weight or more, preferably 0.1% by weight or more, more preferably 0.2% by weight or more. When the concentration of the cyclic compound is less than 0.01% by weight, it becomes difficult to exhibit a significant flying insect repellent effect. The upper limit of the concentration of the cyclic compound is not particularly limited, but in reality, it is the saturated concentration of the cyclic compound in the solvent to be used.

  The flying insect repellent of the present invention can sufficiently exhibit flying insect repellent effect even when a cyclic compound is used alone as one component or active ingredient, but it affects the efficacy of the cyclic compound. So long as it does not interfere with the combined use of other components. Examples of the component that can be used in combination with the cyclic compound include a fragrance component, an insecticidal component, a repellent component, a deodorizing component, a sterilizing component, and a sustained component.

  When the flying insect repellent is a liquid agent, additives such as a surfactant, a solubilizer, a dispersant, a stabilizer, a pH adjuster, and a colorant can be added.

  The flying pest repellent of the present invention prepared as described above can exhibit an excellent flying pest repellent effect by the action of a cyclic compound blended as one component or an active ingredient. In addition, since the flying insect repellent of the present invention does not necessarily contain other components such as a repellent effect sustained component, preparation of the product becomes easy. Furthermore, since it is not influenced by other components, the flying insect repellent effect is also stable.

  The flying insect repellent of the present invention can be used, for example, indoors such as entrances, kitchens, toilets, living rooms, bedrooms, closed spaces such as warehouses and cars, gardens, eaves, and terraces.

  In order to confirm the flying insect repellent effect of the flying insect repellent of the present invention, the flying insect repellent test described below was conducted.

[Flying insect repellent test]
Four kinds of cyclic compounds (active ingredients) having antibacterial properties used in the present invention are each dissolved in acetone to prepare an acetone solution having a concentration of 0.2% by weight. An agent was used. For comparison, a fragrance component, an antibacterial component, and an insecticidal component were dissolved in acetone in the same manner as in Examples 1 to 4 to prepare an acetone solution having a concentration of 0.2% by weight. It was.

A glass box (24 cm long x 24 cm wide x 27 cm high) with an opening at the top is prepared, and cotton cloth is attached to each of the four inner surfaces of the same area inside the glass box. About the affixed cotton cloth, each acetone solution of Examples 1-4 and Comparative Examples 1-7 was sprayed on the whole cotton cloth (this is made into a process section). The spray amount of the acetone solution (adhesion amount of each component to the cotton cloth) at this time is 5 mg per one cotton cloth, which is 77 mg when converted per 1 m ² . The cotton cloth affixed to the other two opposing surfaces was not sprayed with an acetone solution (this is assumed to be an untreated section). In this glass box, 20 female adult mosquitoes were released as flying insects and covered with a wire mesh. Then, the number of mosquitoes moored on the cotton cloth inside the glass box was measured every predetermined time until 30 minutes after the start of the test, and the repellent rate (%) of the flying pest was obtained based on the following formula.
Repelling rate (%) = (X−Y) / X × 100
X: Total number of insects moored on cotton cloth in untreated area Y: Total number of insects moored on cotton cloth in treated area

  Table 1 shows the various components used in Examples 1 to 4 and Comparative Examples 1 to 7, and the results (repelling rate) of the flying insect repellent test.

  The flying pest repellents containing the cyclic compounds of Examples 1 to 4 as active ingredients all showed a repellent rate of Culex pipiens exceeding 80%, and showed an excellent flying pest repellent effect. In particular, the flying insect repellent of Example 1 containing 3-methyl-4-isopropylphenol as an active ingredient has a repellent rate of Culex mosquito reaching 100%, confirming a strong flying insect repellent effect.

  On the other hand, although the chemical | medical agent of the comparative examples 1 and 2 uses a fragrance | flavor component, the repellent rate of the squid was 65% or less, and it was an inadequate result unsuitable for practical use. The drugs of Comparative Examples 3 to 6 use an antibacterial component (but not a cyclic compound), but the repellent rate of Culex mosquito is 0 to 23%, and the results show almost no flying insect repellent effect. became. Although the medicine of Comparative Example 7 used an insecticidal component, the repellent rate of Culex mosquito was only 72%, and a sufficient effect was not obtained.

  The flying insect repellent of the present invention can be used for, for example, textile products such as clothing, futons, pillows, curtains, and automobile seats. For example, insect repellents applied to human skin, pets, livestock, etc. It can also be used as an insect repellent applied to the epidermis or hair of animals.

Claims (3)

A flying insect repellent containing only 3-methyl-4-isopropylphenol as an active ingredient having a repellent effect on mosquitoes in a solvent and not containing other components .   A flying insect repellent containing only orthophenylphenol as an active ingredient that exhibits a repellent effect on mosquitoes in a solvent and no other ingredients.   The flying insect repellent according to claim 1 or 2, wherein the content of the active ingredient in the solvent is 0.2% by weight or more.