JP2020158474A - Female lice repellent - Google Patents

Abstract

To provide a female lice repellent that has a slight content, is not high in production cost, and does not give anxiety or unpleasant feeling even when adhered by spraying directly to clothes or human body during use.SOLUTION: Among essential oils having a lice repellent effect, with at least one kind of cananga oil, peppermint oil, cypress oil, mint oil, lemon glass oil, cinnamon oil, vetiver oil, spear mint oil, fennel oil, ilang-ilang oil, geranium oil, star-anise oil, alpinia speciosa oil, citronella oil, nut meg oil, elettaria oil, ginger oil, setter wood oil, clove oil, japanese cypress oil, anise oil, tea tree oil, lavender oil, coriander oil, clary sage oil, juniper berry oil, black pepper oil, patchouli oil, rose marry oil, and eucalyptus oil as an effective component, a content of the essential oils is 0.1 to 1.0 w/v %.SELECTED DRAWING: None

Description

The present invention relates to a female lice repellent containing a trace amount of essential oil as an active ingredient.

Conventionally, as a repellent for sanitary pests such as lice, 0.08 to 25.0% by volume of N, N-diethyl-m-toluamide, 0.003 to 20.0% by volume of essential oil, and water have been used. There is one containing (Patent Document 1).

The essential oils contained in the sanitary pest repellent include grapefruit, geranium, rosemary, anise, almoise, Iran Iran, orange, cananga, chamomile, cardamon, cayupte, clary sclarea, cloves, coriander, cypress, sandalwood, cedarwood, citronella. The sanitary pest repellent has a useful repellent effect due to the synergistic effect of N, N-diethyl-m-toluamide and the essential oil, and the blending ratio is higher than that of the conventional example. It is said that it can be greatly reduced.

Further, as a conventional sanitary pest repellent, there is one containing a phenylpropanoid compound and a cyclic sesquiterpene compound (Patent Document 2).

In addition to the phenylpropanoid compound and the cyclic sesquiterpene compound, the sanitary pest repellent may contain any component such as natural essential oils other than clove oil and antioxidants such as vitamin C and vitamin E. There is. The raw materials for natural essential oils are grapefruit, geranium, rosemary, anise, almoise, Iran Iran, orange, cananga, chamomile, cardamon, cayupte, clary sclarea, coriander, cypress, sandals, as well as the sanitary pest repellents mentioned above. Examples are those extracted from wood, cedar wood, citronella, etc., and it is said that the essential oils obtained from these raw materials also have a useful repellent effect against sanitary pests.

Japanese Unexamined Patent Publication No. 2014-2015581 JP-A-2017-114770

However, the conventional sanitary pest repellents described in Patent Document 1 and Patent Document 2 do not mention the repellent effect in the sex of males and females at all.

Among hygiene pests, for example, lice are ectoparasites that suck the blood and body fluids of mammals, body lice inhabit clothing, head lice inhabit hair, and lice inhabit pubic hair, each breeding in these habitats. To do. These lice are incomplete metamorphosis in which larvae directly metamorphose into adults, and become adults from eggs through larvae. The lifespan of adults is about 3 weeks for lice and about 1 month for body lice and head lice, but body lice are generally longer than head lice. In addition, the number of eggs laid in a lifetime is about 50 for lice and about 100 to 200 for head lice and head lice, but the number of body lice is generally larger than that of head lice.

By the way, in order to control the next-generation population of sanitary pests, for example, a method of sterilizing sanitary pests and releasing them into the environment and suppressing the occurrence of next-generation individuals by mating with sterile insects has been carried out. There is also an example of the extinction of. In addition, research is underway to genetically mutate female mosquitoes that transmit infectious diseases such as malaria, dengue fever, and yellow fever to maleize them without leaving offspring, and to reduce the number of females. Attempts to reduce the population itself by controlling the number of next-generation individuals in this way are extremely effective methods.

Therefore, a repellent that has a stronger repellent effect on female lice than males can effectively repel spawning females and reduce the absolute number of next-generation eggs. As a result, it is thought that the reproduction of lice can be effectively prevented, but conventional sanitary pest repellents have not considered the repellent effect in male and female sex at all.

Further, the conventional sanitary pest repellent described in Patent Document 2 does not describe the effective content of the lice repellent ingredient, but the sanitary pest repellent described in Patent Document 1 is a lice repellent ingredient. The content of a certain N, N-diethyl-m-toramide is 0.08 to 25.0% by volume, and the intermediate value considered to have the optimum lice repellent effect is about 12.5% by volume. ing. Similarly, the content of the essential oil, which is a lice repellent component, is 0.003 to 20.0% by volume, and the median value at which the lice repellent effect is considered to be optimal is about 10.0% by weight. There is.

Therefore, the conventional sanitary pest repellent has a large content of the lice repellent effective component, which is considered to be optimal, and the manufacturing cost is high, and at the time of use, the lice are directly sprayed or attached to the clothes or the human body. In some cases, it may cause anxiety and discomfort.

Therefore, the present invention pays attention to the repellent effect on the sex of male and female lice, and provides a repellent having a particularly strong repellent effect on females, the content thereof is very small, and the production cost is not high. The purpose of the present invention is to provide a female lice repellent that does not cause anxiety or discomfort even when it is directly sprayed onto clothing or the human body during use.

The female sardine repellent of the present invention includes cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, kehi oil, vetiver oil, spare mint oil, fennel oil, and ylang ylang oil, among the essential oils having shirami repellent effect. Geranium oil, star anis oil, moon peach leaf oil, citronella oil, nutmeg oil, cardamon oil, ginger oil, setterwood oil, clove oil, hinoki oil, anis oil, tea tree oil, lavender oil, coriander oil, clarisage oil, juniper berry At least one of oil, black pepper oil, patchouli oil, rosemary oil, and eucalyptus oil is used as an active ingredient, and the content of the essential oil is 0.1 to 1.0 w / v%.

The female sardine repellent of the present invention includes cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, keihi oil, vetiver oil, spare mint oil, geranium oil, and moon peach leaf among the essential oils having shirami repellent effect. Oil, citronella oil, cardamon oil, ginger oil, setterwood oil, clove oil, hinoki oil, anis oil, tea tree oil, coriander oil, clarisage oil, juniperberry oil, black pepper oil, patchouli oil, rosemary oil, eucalyptus oil At least one of the above is used as an active ingredient, and the content of the essential oil is 0.1 w / v%.

Further, the female sardine repellent of the present invention includes cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, keihi oil, vetiver oil, spare mint oil, fennel oil, and Iran Iran among the essential oils having shirami repellent effect. The essential oil contains at least one of oil, citronella oil, nutmeg oil, cardamon oil, ginger oil, tea tree oil, lavender oil, coriander oil, juniper berry oil, black pepper oil, patchouli oil, rosemary oil, and eucalyptus oil as active ingredients. The content of is assumed to be 0.5 w / v%.

The female sardine repellent of the present invention includes essential oils having a shirami repellent effect, such as hiba oil, ylang ylang oil, geranium oil, moon peach leaf oil, citronella oil, ginger oil, setter wood oil, hinoki oil, and anis oil. At least one of coriander oil, black pepper oil, patchouli oil, and rosemary oil is used as an active ingredient, and the content of the essential oil is 1.0 w / v%.

The female lice repellent of the present invention is configured as described above, and since it has a strong repellent effect on females even with a small amount of content, the manufacturing cost does not increase and it is sprayed directly onto clothing or the human body at the time of use. Even when it is attached by such means, it does not give anxiety or discomfort.

It is explanatory drawing of the test method performed in order to confirm the repellent effect in the sex of male and female of the lice of this invention.

Hereinafter, the female lice repellent of the present invention will be described in detail.

In the present invention, the essential oils having a shirami repellent effect include cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, kehi oil, vetiver oil, sparemint oil, fennel oil, ylang ylang oil, geranium oil, and staranis oil. , Moon peach leaf oil, citronella oil, nutmeg oil, cardamon oil, ginger oil, setterwood oil, clove oil, hinoki oil, anis oil, tea tree oil, lavender oil, coriander oil, clarisage oil, juniper berry oil, black pepper oil, Examples include patcholi oil, rosemary oil and eucalyptus oil. In the present invention, when the content of these essential oils is 0.1 to 1.0 w / v%, the lice repellent effect on females is stronger than that on males.

In the present invention, among the essential oils having a lice repellent effect, the following essential oils have a female to female repellent effect ratio of about 1.5 times or more.

First, among the essential oils having a shirami repellent effect, cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, kehi oil, vetiver oil, sparemint oil, geranium oil, moon peach leaf oil, citronella oil, cardamon oil, The contents of ginger oil, setter wood oil, clove oil, hinoki oil, anis oil, tea tree oil, coriander oil, clari sage oil, juniper berry oil, black pepper oil, patchouli oil, rosemary oil, and eucalyptus oil are 0. The one set to 1 w / v% can be mentioned.

Next, among the essential oils having a shirami repellent effect, cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, kehi oil, vetiver oil, sparemint oil, fennel oil, ylang ylang oil, citronella oil, nutmeg oil. , Cardamon oil, ginger oil, tea tree oil, lavender oil, coriander oil, juniper berry oil, black pepper oil, patchouli oil, rosemary oil, eucalyptus oil content of 0.5w / v% respectively. Be done.

And, among the essential oils having the shirami repellent effect, hiba oil, ylang ylang oil, geranium oil, moon peach leaf oil, citronella oil, ginger oil, setterwood oil, hinoki oil, anis oil, coriander oil, black pepper oil, patcholi Examples thereof include oil and rosemary oil having a content of 1.0 w / v%, respectively.

Further, in the present invention, among the essential oils having a lice repellent effect, the following essential oils have a female to female repellent effect ratio of about 2.0 times or more.

First, among the essential oils having a shirami repellent effect, cananga oil, peppermint oil, lemongrass oil, keihi oil, sparemint oil, geranium oil, moon peach leaf oil, cardamon oil, ginger oil, setterwood oil, clove oil, and anis oil. , Tea tree oil, coriander oil, clarisage oil, black pepper oil, patchouli oil, and eucalyptus oil each having a content of 0.1 w / v%.

Among the essential oils having a shirami repellent effect, the contents of hiba oil, peppermint oil, kehi oil, vetiver oil, spearmint oil, ylang ylang oil, coriander oil, juniper berry oil, black pepper oil, and eucalyptus oil are respectively. The one set to 0.5 w / v% can be mentioned.

The female lice repellent of the present invention is applied by spraying on clothing, towels, sheets, blankets, duvets, pillows and the like. For spraying, a repellent prepared in a solution, a milky lotion, a dispersion, or the like may be filled in a spray can, a hand pump, or the like to prepare an aerosol or a spray.

Examples of those used when formulating the female lice repellent of the present invention include the following.

Examples of the solvent include methanol, ethanol, ethylene glycol, ethylene glycol monomethyl ether, n-propanol, isopropanol, 1,2-propanediol, 1,3-propanediol, glycerin and the like.

Examples of the surfactant include anionic surfactants (for example, fatty acid salts, monoalkyl sulfates, alkylpolyoxyethylene sulfates, alkylbenzene sulfonates, monoalkyl phosphates, etc.) and cationic surfactants (for example, alkyltrimethyls). Ammonium salt, alkyldimethylammonium salt, alkylbenzyldimethylammonium salt, etc.), amphoteric surfactant (eg, alkyldimethylamine oxide, alkylcarboxybetaine, etc.), nonionic surfactant (eg, polyoxyethylene cetyl ether, polyoxyethylene stearyl, etc.) Examples thereof include polyhydric alcohol fatty acid esters such as ether, glycerin fatty acid ester, sorbitan fatty acid ester, and sucrose fatty acid ester, fatty acid ester of polyoxyethylene-added polyhydric alcohol, and fatty acid diethanolamide.

Examples of the antioxidant include vitamin C (ascorbic acid), vitamin E (α-tocopherol), BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole), sorbic acid, potassium sorbate, sodium sulfite, and the like. Examples of the agent include methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, isopropyl paraoxybenzoate isopropyl paraoxybenzoate, butyl parahydroxybenzoate, isobutyl parahydroxybenzoate, paraben parahydroxybenzoate and the like. Furthermore, in addition to the above components, N, N-diethyl-m-toluamide (DEET), icaridin, IR-3535, p-menthane-3,8-diol, pH adjuster, buffer, fragrance, pigment, etc. are blended. can do.

Next, the female lice repellent of the present invention will be described in detail based on specific examples.

[Repellent efficacy test in sex of lice]
First, each of the test essential oils having the lice repellent effect shown in Tables 1 to 3 is dissolved in 10.0 ml of ethanol, diluted with water, and a 0.1 w / v% solution of each test essential oil, 0.5 w /. A v% solution and a 1.0 w / v% solution were prepared.

Next, each of the two essential oils having the same amount of lice repellent effect shown in Tables 4 and 5 was dissolved in 10.0 ml of ethanol, diluted with water, and 0.1 w / of each essential oil. A v% solution and a 1.0 w / v% solution were prepared.

Then, as shown in FIG. 1, a filter paper 2 was spread over the entire bottom surface of each glass petri dish 1 having an outer diameter of 90 mm, and 500 μl of each of the adjusting solutions shown in Tables 1 to 5 was impregnated into 2.5 cm × 2. A 5 cm square filter paper 3 was installed so as to be in contact with the inner wall of each glass petri dish 1.

Therefore, 10 male and female body lice were released into each glass petri dish 1 from the position where the Rasha cloth 3 was installed to the position P on the opposite side of the center of the glass petri dish 1. After 60 minutes had passed, the number of body lice existing in the treated area (on Rashafu 3) and the untreated area (on filter paper 2) was counted, and it was determined that the body lice that did not exist in the treated area could be repelled. The body louse cannot climb the inner wall of the glass petri dish 1 and does not escape to the outside of the glass petri dish 1.

The repellent efficacy test was repeated three times to obtain the repellent rate and efficacy ratio of male and female body lice as shown in Tables 1-5. The repellent rate (%) was calculated by the total number of male or female lice existing in the three untreated plots / the total number of three test lice (30 lice), and the efficacy ratio was the female repellent rate / male. It was calculated by the repellent rate of.

[Evaluation of repellent efficacy in sex of lice]
As shown in Table 1, when the essential oil content is 0.1 w / v%, the repellent rate of ginger oil is 3.3% (1/30) for males and 30% (9/30) for females. The potency ratio of females to males was highest at 9.09. Next, the potency ratio of females to males was higher in the order of eucalyptus oil, spearmint oil, kehi oil, clary sage oil, and black pepper oil, respectively, 4.97, 4.33, 3.51, 3.01, 3. It was 01. Therefore, it can be evaluated that these essential oils have a very strong repellent effect on females at a content of 0.1 w / v%.

When the content of the essential oil is 0.1 w / v%, the repellent rate of orange oil is 16.7% (5/30) for males and 3.33% (1/30) for females, and males. The potency ratio of females to males was 0.20, and the potency ratio of females to males was conversely lower.

As shown in Table 2, when the essential oil content is 0.5 w / v%, the mint oil repellent rate is 13.3% (4/30) for males and 60% (18/30) for females. The potency ratio of females to males was the highest at 4.51. Next, the potency ratio of females to males was higher in the order of vetiver oil, black pepper oil, hiba oil, and spearmint oil, which were 2.84, 2.80, 2.37, and 2,15, respectively. Therefore, it can be evaluated that these essential oils have a very strong repellent effect on females at a content of 0.5 w / v%.

When the content of the essential oil is 0.5 w / v%, the repellent rate of orange oil is 13.3% (4/30) for males and 10.0% (3/30) for females. The potency ratio of females to males was 0.75, and the potency ratio of females to males was conversely lower.

As shown in Table 3, when the essential oil content is 1.0 w / v%, the repellent rate of coriander oil is 46.7% (14/30) for males and 90.0% (27 /) for females. The ratio of female to male was highest at 1.93. Next, the potency ratio of females to males was highest in the order of lunar peach leaf oil, ginger oil, black pepper oil, and rosemary oil, which were 1.86, 1.80, 1.80, and 1,70, respectively. Therefore, it can be evaluated that these essential oils have a very strong repellent effect on females at a content of 1.0 w / v%.

When the content of the essential oil is 1.0 w / v%, the repellent rate of orange oil is 40.0% (12/30) for males and 40.0% (12/30) for females. The potency ratio of females to 1.00 is 1.00, and the repellent potency of males and females can be evaluated to be the same.

As shown in Table 4, when the content of the essential oil in which the two types are combined is 0.1 w / v%, the potency ratio of female to male is 8.46 in the same amount of spearmint oil and tea tree oil. It became the highest. Next, the potency ratio of females to males was higher in the order of lemongrass oil and kehi oil, spearmint oil and nutmeg oil, peppermint oil and spearmint oil, clove oil and tea tree oil in the same amount, respectively. It was 46, 4.01, 3.76, 3,76. Therefore, it can be evaluated that the combined content of these essential oils has a very strong repellent effect on females at a content of 0.1 w / v%.

As shown in Table 5, when the content of the essential oils of the two types combined is 1.0 w / v%, the same amounts of spearmint oil and tea tree oil, and clove oil and tea tree oil are combined, but the female relative to the male. The potency ratio was highest at 3.00, respectively. Next, the potency ratio of females to males was higher in the order of lemongrass oil and spearmint oil, lemongrass oil and tea tree oil, and spearmint oil and clove oil, respectively, in the order of 2.45 and 2.40, respectively. It was 2.33. Therefore, the combined content of these essential oils can be evaluated as having a very strong repellent effect on females at a content of 1.0 w / v%.

Claims (4)

Among the essential oils that have the effect of repelling shirami, cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, keihi oil, vetiver oil, sparemint oil, fennel oil, ylang ylang oil, geranium oil, star anis oil, moon peach leaf Oil, citronella oil, nutmeg oil, cardamon oil, ginger oil, setterwood oil, clove oil, hinoki oil, anise oil, tea tree oil, lavender oil, coriander oil, clarisage oil, juniper berry oil, black pepper oil, patchouli oil, A female sardine repellent that contains at least one of rosemary oil and eucalyptus oil as an active ingredient and has an essential oil content of 0.1 to 1.0 w / v%. Among the essential oils that have the effect of repelling shirami, cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, keihi oil, vetiver oil, sparemint oil, geranium oil, moon peach leaf oil, citronella oil, cardamon oil, ginger oil, At least one of setterwood oil, clove oil, hinoki oil, anis oil, tea tree oil, coriander oil, clarisage oil, juniper berry oil, black pepper oil, patchouli oil, rosemary oil, and eucalyptus oil is used as an active ingredient in the essential oil. A female sardine repellent having a content of 0.1 w / v%. Among the essential oils that have the effect of repelling sardines, cananga oil, peppermint oil, hiba oil, peppermint oil, lemongrass oil, keihi oil, vetiver oil, sparemint oil, fennel oil, Iran Iran oil, citronella oil, nutmeg oil, cardamon oil, At least one of ginger oil, tea tree oil, lavender oil, coriander oil, juniper berry oil, black pepper oil, patchouli oil, rosemary oil, and eucalyptus oil is used as an active ingredient, and the content of the essential oil is 0.5 w / v%. A female sardine repellent characterized by being present. Among the essential oils that have the effect of repelling shirami, hiba oil, ylang ylang oil, geranium oil, moon peach leaf oil, citronella oil, ginger oil, setter wood oil, hinoki oil, anis oil, coriander oil, black pepper oil, patchouli oil, rose A female shirami repellent that contains at least one type of marie oil as an active ingredient and has a content of the essential oil of 1.0 w / v%.

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