JPS62500935A - Long-acting pyrethrum/pyrethroid-based insecticide with added silicone stabilizer - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] name: Long-acting pyrethrum/birethroid based silicone stabilizer added to kill insect repellent field of invention The invention generally relates to non-toxic natural insecticides and those made analogous to such insecticides. Concerning synthetic derivatives. These natural insecticides (e.g. pyrethrum) are of concern in the environment. It is characterized by an extremely short period of validity. by their synthesis Similar substances (e.g. pyrethroids) exhibit similar properties but to a lesser extent; Therefore, the present invention more particularly relates to improvements based on pyrethrum and/or synthetic viretroids. based on pyrethrum and/or synthetic sebirethroid (for improved insecticidal compositions). , they achieve a significant extension of the effective insecticidal properties of active insecticides by their stabilization. manifest.

light plate best view Biologically active drugs for controlling ectoparasites, etc. are necessities of life, and especially It is essential to the livelihood of commercial agriculture and the well-being of human and pet societies. fruit In some cases, these drugs are exposed to hostile chemical environments (e.g. oxygen and ultraviolet light from sunlight). their beneficial effects only during the period during which their active chemical structure can be maintained. sustain fruit. Chemical decomposition caused by environmental factors can cause natural pesticides, especially chrysanthemums. A long article on pyrethrum, a long-known natural insecticide present in flower extracts. It was a temporary problem.

Pyrethrum is rapidly detoxified by mammalian phosphorus systems and can be applied to livestock and plants as well. It is known for being safe and easy to hold. (LD of rats is 500-100 It is in the range of 0■/kg. -11 Kashida, G.I., “Pyrethrum, natural insecticide 1 , Adeka Mink Press (Casida, JE, Pyrethrum, ↑ he Natural Tnsecticide, “Academic Pr ess), 1973), and pyrethrum may be teratogenic, carcinogenic, or mutagenic. Not inducing. These properties make pyrethrum highly suitable for pest control in a variety of applications. It is considered a promising drug.

The major drawback of pyrethrum is its instability in the environment. It begins at the same time as the extraction from certain chrysanthemum flowers, and the substances to be processed, such as animal skin, I I! ! After being applied to the surface of an object, it proceeds at substantially increased speed. The result is extreme It has a very short effective lifespan (several hours), which makes it ideal for general long-term pest control. Closes the door as a practical alternative. Also, compared to pyrethrum, synthetic birethroid Although they generally exhibit improved stability, they also exhibit characteristic degradation, especially in the environment. (Miskus and Andrews) ) (Kosei Shishusara) has been reported to be stable for about 4 hours as allethrin.

).

In recent years, long-term pest control has generally relied on synthetic insecticides that are more stable in nature (e.g., chlorine). hydrocarbons, carbamates and olkaline phosphates). They remain effective at controlling pests for several days or weeks after exposure to the environment. have the ability to maintain However, it should be noted that these pesticides are highly characterized by high mammalian toxicity and often highly toxic Cannot be used more than once within 4 days.

In fact, many such insecticides are effective in controlling ectoparasites in particularly susceptible livestock such as cats. It is so toxic that it cannot be used safely due to regulations.

Of particular note with regard to livestock, the life cycle of most ectoparasites is generally absent from the host animal. Therefore, to control such pests requires treatment of the animal's general living environment. various long-acting However, toxic synthetic insecticides can be used outdoors (in dog sheds, lawns, courtyards, etc.) , bed and moving ¥! IJfil is suitable for this purpose, including indoor use such as sleeping areas. often used. Pet owners often use these synthetic pesticides indiscriminately However, this poses a substantial toxic risk not only to the owner but also to the animal being protected. It is recognized that it is exposed to Moreover, the aforementioned dangers are The same or similar toxic active substances may be used to control other types of pests. Compounded by use in the pet's general environment.

Given such issues and the growing interest in safety and freedom from toxicity, Irrigation, Km synthetic insecticides, biodegradable pyrethrum and its synthetic analogues (e.g. Considerable efforts are currently being focused on replacing them with pyrethroids.

Serving America and planning to escape In the early 1930s, there was considerable interest in extending the insecticidal lifespan of pyrethrum. was held. Early efforts included the use of hydroquinone, tannic acid, and resorcinol. Addition of antioxidants and prevents pyrethrum from decomposing due to oxidation and exposure to sunlight This included the addition of UV absorbers. Despite these additions, insecticidal The effective life of the agent did not increase significantly. Appropriate star insect repellent from Africa (main production area) During World War II, when chrysanthemums were not available, available stocks of pyrethrum were used up. Now widely used along with pyrethrum to control pests of humans, livestock and plants Intensive research has been done on synergists. Synergists will increase the effectiveness of pyrethrum. It acts like a sea urchin. Pyrethrum in particular causes paralysis, not complete death. . Synergists such as thiocyanates can compensate for the paralytic effects of pyrethrum and completely eliminate death. can be set.

Six insecticidal components of pyrethrum extract have now been identified and characterized by their steric configuration. The insecticidal activity of these fractions has been well studied.

This fraction contains pyrethrin II, which represents the so-called chrysanthemate group, cinerin I and Jasmolin■, pyrethrin■ representing the so-called biretrade group, and cinerine It has been identified as ■ and jasmolin ■.

The activities of pyrethrin I and cinerin have been intensively studied, and the activities of pyrethrin I and cinerin Agriculturists and Food Encyclopedias by Andrews ure and Food Chemistry), Volume 20, Fish 2.197 2, pp. 313-315, “Pyrethrin and Allethrin Safety” Stabilization of Pyrethrins and A 11ethrin)”. Ndles was tested in the presence of UV screening agents to study the rate of decomposition. Phosphorus ■ and Cinelin I were exposed to sunlight for 4 hours. hexane, kerosene & selected city Test formulation i was prepared using various organic solvents including commercially available mineral oil. tI2. thing Oil is the preferred solvent due to its stability and is recommended when antioxidants are included in the formulation. Good stability can be obtained. However, even in the presence of antioxidants, sunlight After just 4 hours of exposure to was recognized. This t1 loss is caused by kerosene, the excipient with which pyrethrum is commercially blended. It was particularly large in the formulations prepared in . Hence Miskus and Andrews Therefore, according to the exemplified paper, the stability of pyrethrum is about 4 hours, and it is not commercially available manually. The stability in kerosene vehicles is claimed to be even lower. Things to be careful of Miskus and Andrews published an allele based on the same series of experiments in the same paper. It has been reported that the stability of Torin (synthetic biretroid) is similar to that of water (4 hours). are doing.

Yuuri Yuri A book that increases several times the effective insecticidal life span previously achieved with pyrethrum-based insecticides The invention originated the idea of a controlled release system by binding pyrethrum into a polymer. It was exhibited. Initially, the proportion of active insecticides in the environment, albeit in extremely small quantities, will be Low molecular weight polymers present in sufficient quantities to inhibit (e.g. for stabilization) Efforts have been directed to the development of pyrethrum-based sprays containing 0 inventors for this purpose. We conducted a series of long-term experiments.

The first series of compositions contained polyvinyl of various molecules as the intended polymer stabilizer. Although formulated with pyrrolidone, these compositions were compared to control compositions containing no polymer. No prolongation of insecticidal activity was achieved compared to . Then polyvinyl acetate and Several other polymers were tested, including polyethyl acrylate and These compositions are extremely difficult to use as liniments for cats and dogs. It has also become clear that it is extremely viscous and cannot be accepted as a cosmetic product.

It has thus become clear that the development of these compositions is unlikely to be successful.

The next set of polymers tested by the inventors was polydimethylsiloxane, which They can be used as non-volatile, water-soluble, low viscosity liquids. liquid silicone controlled release formulation of active insecticides while taking advantage of the beneficial cosmetic effects of pesticides. The purpose was to create. However, all polydimethylsiloxane tested Xanes (from very low molecular weight to very high molecular weight) are diluent isopropanes. When the mol evaporated, it separated into other phases. Therefore, after the diluent evaporates, it becomes a stable liquid It was not possible to obtain a polymer residual composition.

Next, the inventors discovered low molecular weight alkylaryl soricones, particularly tetramethyltetra Phenyltrisiloxane was tested without success. other Most silicones previously tested and reported in controlled release systems of can form polymeric substances on their own and by cross-linking with animal hair matrices. Wear. What's more, silicone's high degree of oxygen permeability allows pyrethrum to decompose more quickly. It was expected that this would happen. However, surprisingly, the above Shiroki Sunpolymer together with pyrethrum and other additives (antioxidants, UV absorbers and repellents) After evaporation of the isopropanol diluent, the resulting residue remains in the homogeneous phase. It had a significantly extended effective insecticidal life compared to the composition. Especially the insecticidal lifespan This is a very large improvement over the 4 hours achieved with conventional technology. It was good. Moreover, siloxane polymers are desirable as well as easy to use due to their low viscosity. It had a unique cosmetic effect. Additionally, the hydrophobic nature of the polymer can cause the residue to look like rain. conferred the ability to persist on the animal body even under unfavorable environmental conditions. Later other alkyria Reel silicone was tested and found to be a similarly compatible stabilizer.

Lord 1 Duke 1m - In IG terms, the present invention relates to pyrethrum, synthetic birethroids and mixtures thereof. an insecticide selected from: an insecticide synergist in an amount effective to provide direct insecticidal action; an amount of an antioxidant effective to protect the pesticide from degradation by oxygen; Qualitatively, permanently liquid and has solvent action for pesticides, synergists and antioxidants. The silicone liquid contains approximately 100% by weight of the active insecticide. Long-acting pestocide composition present in a ratio of 1:10 to 260:l It is about things.

The compositions of the invention are also useful for providing residual insect control in addition to extended insecticidal activity. An effective amount of one or more insect repellents can be included.

Soluble in silicone polymers for compositions that are exposed to light in the ultraviolet range after application. UV absorbers or screening agents can be used to prevent active insecticides from being destroyed by such light. It can be included in an amount effective to protect against exposure to

Another aspect of the invention relates to the inclusion of various carriers or dispersants. , thereby applying the insecticide in liquid form (e.g. spray, solution or shampoo). It can be used as a powder or powder, or as a fume.

The present invention provides many benefits for pest control. For example, as one of the benefits, the present invention provides are generally non-toxic and naturally unstable insecticides (pyrethrum, synthetic birethroids and based on the same insecticide (based on mixtures thereof), while Insecticidal compositions may be provided that provide extended insecticidal longevity.

As another benefit, the present invention provides a method for treating substrates such as animal skin 15 or plant surfaces. ) forms a long-lasting coating on the surface of the A stabilized, non-toxic insecticidal composition that resists removal is provided.

As yet another benefit, the present invention utilizes the present invention in the presence of a liquid alkylaryl silicone stabilizer. Long-term insecticidal operation using very small amounts of active agents (insecticides, synergists and repellents) Provides a stable and non-toxic insecticidal composition that can be used for various purposes, thereby providing a low-cost Allows for the production of compositions.

Other benefits of the present invention include ease of use on animal skin and the cosmetic utility of silicones. The object of the present invention is to provide a long-acting insecticidal composition that provides a long-acting insecticidal composition.

The foregoing and other features and benefits of the present invention include sprays, dips, powders, shampoos and The detailed description below, including examples of insecticidal compositions for use as aerosols and aerosols, provides a thorough explanation. It will be understood.

Yuyu two bile removal Bestside compositions of the present invention are now illustrated. Examples of the first series are as propellants It relates to compositions that can be used. Includes animal, plant and general purpose propellants . Examples of the second series include the use of invasive or other suitable methods on animals, such as boning. Regarding immersion liquid for use. Examples of the third series relate to insecticidal powders for animals and plants. most Two total release fumes and two veterinary shampoo formulations are illustrated below.

-C In terms of the composition of the present invention, the composition of the present invention is an insecticide, which cooperates with the insecticide to give a sufficient insecticidal effect. agent, antioxidant that protects pesticides from degradation by oxygen, essential, permanent liquid at 25°C alkylaryl silicone polymers, which have a solvent effect on the aforementioned components in the body; and characterized by the presence of an assembly for applying all the aforementioned components. The formation just mentioned In addition to this, the substrate that has been treated like animal skin can be coated again. It is desirable to provide a residual insect repellent effect in order to prevent I can do it. Additionally, compositions that may be exposed to ultraviolet light (e.g., formed outdoors) (products used for growing animals and plants) that contain ultraviolet screening agents or absorbers. can be made to have The formulations listed below are generally used as repellents and/or UV screeners. containing cleaning agents, but these ingredients may be used in cases where such properties are considered unnecessary. can be removed.

Insecticides according to the invention include pyrethrum, synthetic virethroids and mixtures thereof. The common commercial form of pyrethrum and synthetic birethroids is active added to petroleum distillate solvents. Insecticides (e.g. McLoughlin Baumley King) Gormley King Co., Minneapolis, Minnesota eapolis, Minnesota) from Pre+ll1anPY110CI 20% w/w pyrethrum extract in kerosene available under the trade name DH1175).

In fact, synthetic pyrethrum or pyrethrum is used to control ectoparasites in animals. It is preferable to use it as a mixture with Lloyd, as the former will quickly eliminate pests. This is because the latter (viretroids) generally act more gently. Ru. List of synthetic berethroids that may be used for the practice of the present invention is illustrated below in the specific example shown below. In the example, Adult birethroids are represented by their common names, which are similar to the chemical names used in the table above. It can be contrasted.

Preferred synergists in the practice of this invention include piperonyl butoxide and n-octoxide. Contains tilvin clohebutene dicarboximide. These synergists are Manokura -McLaughlin GorIIIley King Co.), the latter under the trade name MGK264. can be obtained. Piperonyl butoxide is used as a synergist in fXJ beam construction. However, it has recently been found to be somewhat toxic to cats. MG K264 does not have such L”J and is used in combination with piperonyl butoxide or its combination. By using it instead, the toxicity is advantageously reduced when used in sensitive animals. can be reduced. Implements a list of other synergists that may be used in the practice of this invention Shown after the example.

A preferred antioxidant is butylated hydroxytoluene (BIT). This substance is It is easily available as a commercial product, such as Shelwyn-Williams ( Sherwton Williams Company) Ru. Other antioxidants are shown in the table after the examples.

A preferred ultraviolet (UV) protectant is 2-ethylhexyl-p-dimethylaminoben. Zoate and 2-ethylhexyl-2-cyano-3,3'-diphenylacryle The former is located in New Jersey, Belleville (New Jersey, B. e1leville) located at V1n Dyke & Company, Inc. (van Dyk & Company.

Inc.) under the trade name ESCALOL 507, and the latter is New Jersey, Parsippan y) Located at BASF Wayndoft Corporation (WayndoHeC) organization) to tlVINUL N-539 (or UVINUL It can be obtained under the trade name 539). Other preferred tJV absorbers are p -Aminobenzoic acid (PABA). Other UV protection used in embodiments of the invention Protective agents are shown in the table below.

A preferred repellent used in the practice of this invention is di-n-propyl isocincomelone. (Product name of MGK R326 from Mano Claflin Baumley King) ) and 2.3:4°5-bis(2-butylene)tetrahydro=2-ph Ruraldehyde (MGK R11 from Mano Claflin Baumley King) (available under trade names). Other repellents are shown in the specific examples below.

For the silicone polymer component, preferred alkyl alcohols for the practice of this invention include: The reel silicone is shown in Table 1 below.The silicone shown in Table 0 is a pure liquid. All are non-volatile, water-insoluble solvents, and are Based on Mar.

At 25°C (average temperature indoors, which is the environment for domestic pets), it is essentially permanently liquid. Ru. Silicone: Michigan, Midland (formerly Chigan, Midland) Dow Corning Corporation (Dois Corning Corporation) ) can be obtained as a product.

Table 1 - beautiful silicone Yu base each senior person Dow Corning (DOW) Phenyl CORNING, a siloxane with a linear basic structure ) 550 Contains 50% funyl group and 50% dimethyl group in methylsiloxane. So, Fe. Nyl group and methyl group are in equimolar ratio in the side chain Exist at a certain rate. Single-molecule product. molecule Amount 750° Dow Corning 702 Phenylmethylcyclosiloxane and dimethylcyclosiloxane Mixture of loxane.

Dow Corning 704 Tetramethyltetraphenyltrisiloxane. single molecule Product. Molecule 14484.

Dow Corning 705 Pentaphenyltrimethyltrisiloxane. Sheep - molecular biology product. Molecule ff1546.

Dow Corning 710 Phenylmethyltrisiloxane, 44% phenyl convex, 5 6% methyl group content.

Single molecule product. Molecular weight 2600° The table below shows the important characteristics of the silicones shown above at 25°C (77°F). It summarizes the characteristics of In addition to the properties shown in Table ■, preferred silicones have high The main focus should be on being characterized by a certain degree of thermal and chemical stability.

Part ■ Preferred properties of silicone DC550 molecule single component 3X10-' 125 24.5 DC702 molecule mixture Product 1xlO-' 45 30DC704 molecules Single component 2XlO-11393 7, 3DC705 molecule single component 3X10-” 175 36.5 In the following table ■ shows the general parameters of the composition according to the invention. In particular, Table ■ Approximate minimum and maximum ratios and preferred ratios of silicone to insecticide in compositions of The preferred range ratios are shown by weight. The table further includes synergists, antioxidants and ultraviolet light. All preferred ranges of protectants are specified by weight, in the form of one-to-one pesticide ratios. Ru. The amounts of these additional ingredients can vary from the ranges indicated, but The desirability of the specified ranges will be assessed by those skilled in the art. cormorant.

・1m″-is the parameter- Or-”L-ru entering 1 cutting E value crazy proverb entering A! "SuL Silicone: Insecticide 1 : 10 1:5-20:1 260: 1 Insecticide; Synergist 1:50-1 :5 Insecticide: UV protectant 1:10-1:1 Insecticide: Antioxidant 1:10-1:1 The parameters listed in table It can be applied to liquids, powders, shampoos and vapors). Also residual repellent In compositions where effectiveness is desired, one or more repellents as previously indicated. It is also possible to contain. About 0.25% to about 5% (W/ W) of the repellent is sufficient for this purpose at once, and the insecticide-to-one repellent properties No particular ratio is required, but a range of approximately 1:4-1:20 is a broad guideline in practice. It can be used as In all cases, the procedure for applying the remaining ingredients A suitable carrier can be added as a stage. For sprays, dips and shampoos , a volatile carrier is used, a fine powder carrier is used for powders, and an antagonist is used for foggers. Ru. The amount of alkylaryl silicone liquid used in each example is the amount of insecticide used. Effective in wetting the ingredients and any other ingredients present.

Example 1-X relates to a composition for use as a propellant. The table below shows spray agents. Typical formulations used are given in weight percentages. A pair of silicone each The formulation of pesticide ratios is shown in Table ■.

・■-■1 ・-ga na r 几二 2L silicone 0.025. 05. 25 5.20 Insecticide 0.25. 25. 05 0.02 Synergist 1.25 2.5 2.5 0.20 Repellent 0.5 1.0 1.0 0.40 UV protection Protective agent 0.25. 25. 25 0.20 Antioxidant 0.25. 25. 1 3 0.20 repulsive carrier 97.475 9s, 7o 95.82 93.78 The spray formulations given in Table 1 and in the special examples are prepared at room temperature by the following procedure: can be produced, especially suitable for producing large quantities of product on the order of 2,000 gallons. are doing. The antioxidant is usually dissolved in a suitable solvent (e.g. 10-20 parts) which is a volatile carrier. Dissolve in a sufficient amount of 1 part BHT in isopropanol with stirring. stirring Add the insecticide to the previous solution while continuing to add the synergist, tJV protectant and repellent. Add the repellent followed by the remaining volatile carrier.

The resulting product was then slowly added to the silicone liquid and vigorously stamped. Achieve complete aggregation and uniform dispersion, thereby obtaining a homogeneous and stable liquid product. Ru.

Aqueous emulsion compositions (e.g. mixed water/alcohol (Based on 2017) with emulsifier added for phase stabilization), production with slight changes. It should be noted that the law is used. The first step is basically the same as that of the previous method. are the same.

Antioxidants are dissolved in an alcohol carrier and the resulting solution contains pesticides, synergists, and UV protection. Add all protectants and repellents with stirring.

This product is then slowly added to the silicone fluid with vigorous stirring. this Once the first step is complete, add the emulsifier while continuing to stir. Finally, this Add the product slowly to the aqueous phase with stirring.

Susei I skin Phase 1 WIJy Yu Bottom - Ichiri machine - Recitation Kanchiku - Itan Pyrethrum insecticide o, i.

Biperonyl butoxide synergist 0.37 MGK 264 synergist 0.61 MGK R11 repellent 0.20 MGK R326 repellent 0.20 ESCALOL 507 UV absorber 0.25UVINUL 539 UV Absorbent 0.25BHT Antioxidant 0.20 Husband LL 2 4)- Recite the movement t"■υ (upper part) 戊-一分〈盈-blood〈1〈knee%〈w/h〉Silicone〈DC704 Polymer〉0. 51 isopropanol volatile carrier 96.5i petroleum distillate (from pyrethrum concentrate ) 0.40 Inert fragrance 0.40 The following test methods and results for the above formulation demonstrate the effectiveness of the composition according to the invention. Ru. For testing, the above composition was applied to a nonwoven plastic made of high-density polyethylene. Store in a container and trigger the atomizer for the production of a mist or spray on this Attach. The composition is then tested according to the following method.

10 dogs were arbitrarily divided into two groups of 5 dogs each, and newly developed dogs were not fed. Large fleas (Ctenocephalides) and large ticks By placing Rhipicephalus on the skin , exposed to fleas and ticks. A group of dogs were then treated with the formulation of this example. The other group was left untreated as a control group. For each dog in the treatment area Apply light to the entire body surface with a gloved hand, moving across the skin against the condition of the hair. It was sprayed thoroughly. The average dose per animal weight was approximately 2.8 cc per bond. .

The number of fleas and ticks that survived (fleas and Do not remove or infest the mites repeatedly without being harmed by them. We conducted repeated tests on these and measured the probability and persistence of these new parasites. Table V below shows the extended effectiveness of the insecticidal composition against the identified parasites. There is.

anonymous person Surviving Master Kyo Aoi Muzo (2) Tamokusai 0 17.2 14.2 30.8 21.6 processing 3 (hours) 9.0 +4.2 0 19.85 (hours) 3.0 13.2 0 19.61 2.0 12.0 0 16.8 2 0.2 11.2 0 15.2 5 0.8 11.0 0 12.6 Remanuen 6 2.2 20.4 0 36.0 8 1.2 19.8 0 35.0 Remanuen 9 2.8 21.0 0 33.4 12 1.6 20.0 0 34.4 Remanen 13 4.4 22.4 0.2 42.216 3.2 16.6 0.2 32.6 Remanen 17 6.8 28.8 2.0 49.021 4.2 24.4 0 43 ．． 8 Remanen 22 B, 4 29.4 4.6 48.2 Other experiments conducted for comparative oral Contains high levels of active ingredients (e.g. insecticides, synergists and repellents) in The composition of the present invention, i.e. contains antioxidants, UV protectants and silicone polymers. No standard commercially available flea spray was tested against conspecific fleas and ticks. It was used to treat a group of dogs that had been fed. The following table shows the symptoms of parasitic infections caused by this formulation. Although it kills insects immediately, the insecticidal action is extremely short-lived and therefore does not kill fleas and ticks continuously. This shows that the remanufacture occurred within an extremely short period of time.

Kodan dog Live fleas and ticks -1 Manen 27 37 114 950 processing 5 Re-manen 8 Re-manen Somachi 111 Dododan Toe I Tomobatsu” construction Se-Nio and Blood Photography Z h/w Pyrethrum Insecticide 0.05 Biberonil Butoxide Synergist 0.16MGK 264 Synergist 2.0 MGK rllll repellent 0.5 MGK R326 repellent 0.5 ESCALOL 507 tJ V absorber 0.13 LIVINUL 539 tJ V absorber 0.13 Ten 1 Remains and 19 ■Kan Bottom - 1 minute plate - Yu A skin -'' - Red - B HT Antioxidant 0.13 Silicone DC704 Polymer 0.25 Isopropanol Volatile Carrier 95 ．． 55 Petroleum distillate (from pyrethrum concentrate) 0.2 Inert fragrance 0.4 The foregoing formulation contains the ingredients of the composition of Example ■, but with different concentrations of other veterinary sprays. is exemplified. The propellant for both Examples ■ and ■ is silicone polymer DC70. 4, but any of the other preferred silicones may be placed therein. You can get it.

The recipe for this example was the same as previously described using a third group of five dogs. The effect was tested at the same time as in Example 1 according to the treatment, uniformity and test protocol. I tried it. Table 4 shows that this formulation has a level of extended efficacy that is substantially the same as that of Example r. It shows that this has been achieved.

! Yu dog Living fleas and ticks 0 13.4 14.2 25.4 21.6 processing 3 (hours)? , 8 14.2 0.4 19.85 (hours) 2,2 13. 2 0 19.6 + 0.4 12.0 0 16.8 Nozomi JL2 and Pusho) History of surviving fleas and ticks 5 0.4 1+, 0 0 12.6 Remanuen 6 2.2 20.4 0 36.0 8 1.2 19.8 0 35.0 Remanuen 9 1.6 21.0 0 33.4 12 1.4 20.8 0 34.4 Remanen 13 4.6 22.4 0.2 42.216 2.0 16.6 0 32 ．． 6 Remanen 17 5.2 28.8 L4 49.021 1.4 24.4 0 43° 8 Remanen 22 6.0 29.4 2.4 48.2 s] 11 The following formulations were formulated with silicone DC550, 704 and 710, respectively. represents two different veterinary sprays.

Φ1 Il, y 3-5 Bottom - 1 minute Nuki - Plate Shooting knee" - Nori Pyrethrum insecticide 0.10 Piveronil Butoxide Synergist 0.37 MGK 264 Synergist 0.61 Multipurpose WIIk13-5 (continued) Bottom - 1 minute Ljit 1 skin -"-? L MGK R11 repellent 0.20 MGK R326 repellent 0.20 ESCALOL 507 UV absorber 0.25UVINtlL 539 UV Absorbent 0.25BHT Antioxidant 0.20 Silicone DC550 polymer 0.25 isopropanol volatile carrier 9 6.77 Petroleum distillate (from pyrethrum concentrate) 0.40 Inert fragrance 0.40 The propellant represented by the above formulation was as described in connection with Example 1. A test was conducted to compare the effects using basic methods. Each spray was administered to 4 dogs. A separate test group was administered, and another group of four untreated dogs served as a control group. All The dog is treated in a way that does not kill or remove fleas and ticks. Tests were conducted at intervals to determine the number of surviving fleas and ticks. Table 4 and Table ■ are here. The extended effects of these three propellants are shown.

Star U Group of fleas 3 (F) and Rokuka (Ef) “Before treatment 59 81-70- 55 = 3 hours 55 0 100 0 100 0 1005 hours 52 0 100 0 100 0 1001 days 47 0 100 0 100 Q 1 00 star Ut Jin and 21- 1 chimi fW (F) and Roku E bimanen Remanuen 9 75 0100 494.7 3 9612 66 0 100 3 95 ．． 5 1 98.5 Remanen 13 94 29 69.2 17 81.9 16 8316 90 14 84.4 19 78.9 5 94.4 Remanen 17 118 30 74.6 43 63.6 22 B1.421 114 16 86 39 65.8 13 88.6 *First 5 days after treatment of treatment group The effect of flea counts was compared with the pre-treatment counts of the corresponding groups. After the 5th day of re-cum , the number of fleas in the treated group was compared with that in the control plot.

Starcraft shit You 1 tick of 3 (T) and 9 intersections ~ (Et)” Before processing 8070- 103- 65-3 hours 77 12 82.9 17 83.5 16 75.45 hours Between 75 8 88.6 6 94.2 6 91 Table ■ (continued J- 1 day 79 0 100 2 98.1 1 98.52 81 0 100 1 99 1 98.5 Remanen 6 108 1 99.1 3 97.2 4 96.3 Remanen 9 115 3 97.4 9 92.2 3 97.412 92 0100 5 94.6 1 98.9 Remanen 13 121 12 90.1 18 85゜1 12 90.116 122 2 98.4 18 85.2 6 95.1 Remanen '17 123 22 B2.1 37 69.9 10 9], 921 10 7 19 B2.2 32 70.1 9 91.6 *First 5 after treatment of treatment group The effect of daily exposure was compared with the number of mites in the corresponding group before treatment. 5th day again Afterwards, the number of mites in the treated group was compared with the number of mites in the control group.

sharp blood charcoal stand The following formulation represents another animal propellant of the present invention, this particular propellant is a synthetic It is based on permethrin, which is an acid, and a synergist. This composition is addictive to horse skin. Formulated as a particularly useful insect repellent for flies that remains after spraying or wiping. has been done. Carboxyl methyl cellulose, hydroxyethyl cellulose, a Rubia gum, or a thickening agent such as alginate or carrageenan, can be added to the sticky adhesive. can be added to make a solution.

Separate Yu 11 battles Bottom - 1 minute Plate - Bamboo shoots 1m -% w/w Permethrin insecticide 0.10 Pyrethrum insecticide 0.10 Piperonyl butoxide t+L') agent 0.50MGK R11 repellent 0.2 0 MGK R326, repellent 0.2゜ Butoxypropylene glycol repellent 1.50 ESCALOL 507 U V absorber 0.2511VINUL 539 UV absorber 0.25B'H T Antioxidant 0.20 C’J: 1-7 DC704 B’J7-0.25 Petroleum distillate (insecticide concentrate? ), 0.55 isopropanol volatile carrier 55.9 water volatile carrier 40.0 Tsubuse charcoal This example illustrates another veterinary spray of the invention. This special propellant is synthetic Based on pyrethrum synergized with deltamethrin, a biretroid, it provides immediate The purpose is to have a knockdown effect and an insecticidal effect. What you should be careful about is delta Thorin has low insecticidal activity due to its extremely high insecticidal activity (10 times greater than that of bur, metrin). It can be used at very high insecticide concentrations, which means that silicone can be used at extremely low concentrations. Facilitates implementation of inventions in polymers. This formulation is silicone polymer The small amount of insecticides required reduces costs and provides immediate knock-down action and provides effective insecticidal action and extended effective insecticidal life.

Flies Bottom - one minute Dan - thick M - eco-friendly Deltamethrin (100χ industrial standard) Insecticide 0.01 Pyrethrum Insecticide 0. 05 MGK 264 18 strength agent he30 MGK R11 repellent 0.25 ESCALOL 507 UV absorber 0.1011 VINIIL 539 UV absorber 0.10BHT Anti-irritant 0.06 Silicone DC705 Polymer 0.10 Petroleum Distillate Th (Pyrethrum; From Condensate ) 0.20 Isopropanol Volatile carrier 68.83 Ethanol Volatile ( Dantai 30.0 The above spray is particularly useful as a persistent ectoparasite and insect repellent for dogs. Arco Isopropanol and ethanol for use in cats irritated by alcohol odor. can be exchanged with water (except in sufficient quantities to obtain volatile solvents during production) , and also add a small amount (for example 0.1%) of a cationic surfactant to a stable emulsion i) A surfactant with an HLB value (!l water group hydrophobic convex balance) of about 13 may be added for Sex agents are suitable for this purpose. Exemplary surfactants are available from Ill. Armak, Department of Industrial Chemistry (Armak, Chicago) Company, Industrial Chemicals Divisio CAT-13 available from

Tianyu Endan The following formulations are for two other pyrethrum-based veterinary sprays.

erect) JWu 嘱l! l Bottom - 1 minute Machine - Blood ヱ” Agency χ w/w pyrethrum insecticide 0.10 Pepyronyl Butoxide Synergist 0.37 MGK 264 Synergist 0.61 MGK R1+ Repellent 2. O MGK R326 repellent 2.0 ESCALOL 507 [J V absorber 2.5tlVINUL 539℃ ) V absorber 2.5BHT Antioxidant 1.0 Silicone DC704 polymer 26.0 isopropanol continuous carrier 61 ．． 52 Petroleum distillate (from pyrethrum concentrate) 0.40 Pyrethrum insecticide, 10 Pepyronyl butoxide synergist, 37MGK 264 synergist, 61 MCK RIL repellent 1. Q MGK R326 repellent 1.0 ESCALOL 507 tJ V absorber 1.51iVFLIL 539 t JV absorber 1.53 HT antioxidant 0.75 Silicone DC704 polymer 14.0 isopropanol volatile carrier 7 8.17 Petroleum distillate (from pyrethrum concentrate) 0.40 Inert fragrance 0.6 Exercising The following table is an exemplary formulation for a general purpose surface spray according to the present invention.

The propellant is based on phenothrin, a synthetic biretroid.

Phenothrin insecticide 1.536 Related compound 1 Insecticide 0.064 Pepyronyl butoxide synergist 8.00p-aminobenzoic acid UV absorber 6.00BHT Antioxidant 1.60 Silicone DC550 Polymer 0.32 Petroleum Distillate (phenothrin concentrate) ) 0.16 Isobrobanol Solvent/Volatile carrier 15.00 Water Volatile carrier 62.32 * Commercially available phenothrin from Mano Claflin Baumley King Concentrate 3 contains 3-phenoxyhensyl d-cis and trans 2,2'-di Other methyl-3-(2-methylpropenyl)cyclopropanecarboxylate Including isomers.

This propellant is formulated in the form of a concentrate, one part of which is mixed with 32 parts of water (approximately 4 oz. gallon) and a rate of 1 gallon of diluted spray per 1000 square feet of surface When used outdoors, it may be harmful to outdoor pests (e.g. fleas, ticks, bed bugs, ants, It is useful for suppressing insects such as worms, webworms, mole crickets, etc. An example is vegetation, grass. Rooms, including use in living spaces, courtyards, doghouses, entryways, gardens, balconies and small spaces 2,000 square feet for internal use (e.g. control of fleas, ticks, cockroaches, etc.) For example, apply 1 gallon to the surface of the floor, food, and closet. Apply diluted spray around baseboards, behind fixtures, under furniture and on pet beds. Spray.

all over the place This example provides an alternative formulation for a commercially available propellant. This propellant 1 is a synthetic pellet. It is based on d-transarethrin, which is It is formulated for use in diluted form as described above.

Two Gua Ling Threats Zhou Ying I Ki-Ikkou Sashi-1 Kanku-X w/w d-transarethrin Insecticide 0.32 Related compounds Insecticide 0.02 MGK264 Synergist 3,40 p-Aminobenzoic acid UV absorber 1.92BHT Antioxidant 1.60 Silicone DC710 Polymer 6.40 Petroleum Distillate (Insecticide I? Store II Liquid? et al.) o, oi isopropanol solvent/volatile carrier 16. O0CAT13 Emulsifier 1.00 Water volatile 11 bodies 69.33 *Commercially available d-trans available from Maso Claflin Baumley King Contained in allethrin concentrate, 2,2-dimethyl-3-(2-methylpropenyl) 2-allyl-4-hydroxy-3-methyl-2-cyclopropanecarboxylic acid Includes other isomers of clopentene-1 ester.

1st base plate included This example uses tetramethrin, a synthetic biretroid for use in growing crops. The prescription number 9 indicating the formulation of the agricultural spray based on 7; is for bacterial liquid; Preferably diluted with water at 1 quart per 100 gallons of water and 100% per knee car. It is preferable to use gallons of diluted spray.

Igosaku 1 Yu Sasa AM Drinking [Printing] Haruka Hara Nee 1-Upper- Tetramethrin insecticide 4.00 Related compounds “Insecticides” 0.54 Biberonil butoxide synergist 10. OOM GK 264 Synergist i o, o.

p-Aminobenzoic acid UV absorber 4.54BHT Antioxidant 4.54 Silicone DC710 polymer 4.54 isopropanol solvent/volatile carrier Body 20. OO petroleum distillate (from tetramethrin l agricultural liquid) 0.4 water continuous Carrier 36.44 *Commercially available materials available from Masso Claflin Baumley King. Tramethrin? Included in 1ttl products.

**Octylphenoxypolyethoxyethanol Examples X and XI used in animals The emulsified immersion liquid is exemplified.

Basically, the emulsion 11 of the present invention can be maintained in water by using an excessive amount of emulsifier. Contains kill aromatic silicones. The actual emulsifier selected depends on the silicone polymer used. Depends on the nature of the rimmer. Emulsifiers can be mixed using a typical HLB test kit. By testing the stability of silicone-water mixtures at You can choose. Cations that generally have an HLB value between about 13 and about 15 surfactant (e.g. CAT-13 described in Example ①, obtained from the same vendor) CAT15, and mixtures thereof) give good results. liquid formulations and It should be noted that there is no fundamental difference between emulsion formulations. water in emulsion When evaporated, a liquid formulation of isostar is left behind. The emulsions of Examples X and XI are propellants. can be produced by a modified method described in connection with the production of.

19N This example demonstrates a pyrethrum-based animal dip according to the invention.

Study and manga legacy! soil Bottom - One minute match - Plate Man tip - Lヱ Pyrethrum insecticide 1.0 Piveronil Butoxide Synergist 4.0 MGK 264 Synergist 6.0 MGK R326 repellent 2.0 MGK R11 repellent 2.0 ESC5LOL 507 UV absorber 1.011nivul 539 UV absorption Absorbent 1.0B HF Antioxidant 1.0 Silicone DC705 Polymer 20.0 Petroleum Distillate (from Pyrethrins) 4. 0 Isopropanol solvent/volatile carrier io, o.

Water Volatile carrier 47.5 This dipping agent is used to treat fleas, ticks, and lice in dogs and cats by dipping or using a sponge. Formulated for use (after dilution at a rate of 1 oz/gallon water) to suppress has been made into Also used as a spray for cattle and horses against ticks, sandflies and other pests. It can also be used for immediate and residual inhibition of f. 1 per sneaker Diluted with 91 parts of 1 via+- per 00 gallons of water to remove 11 to control biting and sweating insect pests such as larvae and aphids. ``!'4) 71 (8 industrial and horticultural use) can also be sprayed.

Man” 1 state XL This example illustrates another emulsion formulation of the present invention. Prescription B, i-synthetic biretro Based on permethrin and pyrethrum, 0.5 oz per gallon of water when used. It is shown as an agricultural product that can be diluted in proportions.

Permethrin, 79 0.0031 Pyrethrum 1.35 0.0053 Piperonyl Butoxide 5.04 0.0!97MGK 264 8.13 L031BMGK R112,710,0106 MGK T'l 326 2.71 0.0106ESCALOL S O73 ,390,0132UVINUL 539 3.39 0.0132BHF 2 ．． 71 0.0106 Silicone D C5509,850,0385D C7049,850,03 85 CA T 13 0.63 0.0 (125 heavy goods - tl12 (continued) CA T 15 0.16 0.0006 Isopropanol 27.10 0. 1059 Wednesday 16.59 99.674 Implementation '++1I X~X'/l shows the formulation of an exemplary agent according to the present invention. Ru. The liquid portion of the powder was compressed using the method described for the propellant in Example Mix as a proboscis, then silica gel (e.g. 5YLOID 244 available from (W, R, Grace Co,) ) can be coated onto a suitable dispersant such as coating For example, is it a liquid? H'4tl was sprayed onto the dispersant powder (carrier) with stirring, and then This can be done by drying the powder in forced air or in a low temperature oven. can. If isopropanol or other volatile solvents are released during drying, soroxane A residue containing a solution of the active substance in the liquid remains on the silica gel.

Calcium carbonate or other inert filler is then added to obtain an economical concentration suitable for use. powder can be increased. The following Table X is the approximate minimum shown in Table ■ and for making the powder compositions of the present invention at maximum silicone-to-insecticide ratios. Examples of common prescriptions. Corresponding treatments for dry powders manufactured according to Table X The details are shown in Table XI.

"Ji (front) 2 transport 2m connection Jf’l prescription 2 Qwa 11) Phenylmethylsiloxane 0.02 5.2 Pyrethrum/Birethroid 0.2 0.02 ratio SKI 1:10 260:1 Synergist 1.0 0.2 , Evacuation agent 0.8 0.2 UV protectant 0.2 0.2 Antioxidant 0.2 0.2 Solvent 10.8 10.0 Support (e.g. silica gel) +0.0 10.0 Petroleum distillate 0.8 0.08 Calcium carbonate, talc, etc. 76.78 73.9 balls General use costume I non-drying □ND- Phenylmethylsiloxane 0.0225 5.7829 Pyrethrum/Birethroid 0.2247 0.0222 ratio s:+ i:io 260:1 Synergist 1.1237 0.2224 Repellent 0.8989 0.2224 UV protectant 0.2247 0.2224 Antioxidant 0.2247 0.222 4 Support (e.g. silica gel) 11.2359 11.1210 Calcium carbonate , talc etc. 86.0449 82.1843 ability iJ [raw The next formulation is a pyrethrum-based animal powder.

■--Quantity-X top Pyrethrum Insecticide 0.182 0.2085MGK 264 Synergist 1.36 1.5584MGK R11 repellent 0.45 0.5156MGK R32 6 Repellent 0. ．． 15 0.5156ESCALOL 507 UV absorber 0.45 0.5156tl VINIIL 539 UV absorber 0.45 0 ．． 5156B, HF Antioxidant 0.45 0.5156 Noricone DC55 0 Polymer 2.00 2.291 Fisopropanol Volatile Solvent 12.0 0-Silica gel zero fraction agent H carrier 10.0 1], 458 powder is particularly suitable. It is prescribed as useful in controlling ticks in dogs and cats. It's also Maki It can also be used by filling powder bags that are hung in fields or pastures. livestock in bag Rubbing the body coats the body with a powder that is insecticidal and repellent against, for example, stable flies. have a positive effect.

Joined the Tsubasa group This example illustrates another pyrethrum-based powder formulation.

徂-1week-hi(point Pyrethrum insecticide 1.0 +, 042 MGK 264 Synergist 6.0 6.250 MGK R11 Repellent 0.5 0.521MGK R326 repellent 0.5 0.521ESCALOL 50 7 UV absorber 1.0 1.042 [IVINUL 539 UV absorber 1.0 1.042B HF Antioxidant 1.0 1.042 Silicone DC 710 Polymer 2.5 2.604 Isopropanol Volatile Solvent 10.0 -Silica gel carrier 10.0 10.416λ ±in y The following formulations are for other powders for animals, especially dogs and cats. Powder is synthetic It is based on the birethroids tetramethrin and phenothrin.

■－－Kokuichi owner Tetramethrin Insecticide 0.2 0.25 Phenothrin Insecticide 0.12 0.15 Related compounds “Insecticides 0.005 0.006 MGK264 Cooperation Agent 3.25 4.064"Ik13 (Continued above) MGKRII Evacuation Agent 0.5 0.625ESCALOL 507 U V Suction Absorbent 0.163 0.20411 VINLIL 539 UV absorber 0.1 63 0.204BHF Antioxidant 1.625 2.032 Noricone DC 702 Polymer 0.325 0.406 Isobrobanol IT exothermic solution 1 2 0.0 - Silica gel 1 piece 12.0 15.00? Silica] earth filler 6 1.616 77.052 *Commercially available biretroid as first described); Thin include.

籏 pierced silk This example describes a growing crop based on the synthetic biretroid, Sivermethrin pyrethrum. It shows the powder formulation for things.

Costume--M-X soil Pyrethrum Insecticide 0.10 0.106 p-aminobenzoic acid UV absorber 1. 50 1.585BHF Antioxidant 1.50 1.585 Silicone DC5 50 Polymer 3.00 3.172 Katou-Ittou-)” (continued-Monday) Ituburobanol Volatile Solvent Application (at a rate of 100 pounds per kneeker) makes it easy to utilize.

For the powder, part of the carrier is placed in a hydrophilic binder, and then transferred to a low-volume granule fertilizer spreading device. It can be applied especially to crown soils and top soils by applying more or mixed with granular fertilizers. Insects that feed on plants in the soil (e.g., black beetles, click beetles, etc.) etc.) can be suppressed.

Elm U Sei 2) 1 Lee - ≧ Ku - 2 Shi I - The following formulation is a synthetic birethroid. -) indicates a powder based on lantharethrin and pyrethrum. special powder below The agent is prescribed to control fleas and ticks on pets.

Related compounds 0 Insecticide 0.07 0.074 Pyrethrum Insecticide 0.10 0. 106MGK 264 Synergist 0.50 0.529MGK R11 Repellent 0.20 0.211MGK R326 repellent 0.20 0.211ESCA LOL 507 U V absorber 0.10 0.106 Ryo 5 (continued) UVINUL 539 UV absorber 0.10 0.106BHF Antioxidant 0.20 0.211 Silicone DC550 Polymer 1.10 1.163 Petroleum distillate 0.41 ~ (from insecticide concentrate) Isopropanol volatile solvent 5.0 - Solica gel placed 10.0 10 ．． 572 Talc Filler 80.59 85.199 (100 mesh) *Contained in commercially available birethroid concentrates such as those described at the beginning.

The final Examples X-Xx are two environmental foggers and two animal foggers according to the invention. An example is shampoo.

Daiarashi dish entering Wataru This example shows a pyrethrum based total release fogger.

Releases at a rate of 1.5 ounces per 500 cubic feet subjected to fogger treatment It is prescribed as follows. Foggers contain antioxidants as previously described for foggers. agent, insecticide, synergist, UV absorber and silicone and then processed using conventional techniques. It can be manufactured by placing it in a pressurized container together with a propellant.

Pyrethrum insecticide 2.0 4.26 Biberonil synergist 4.0 1.74 butoxide MGK 264 Synergist 6.0 2.55BHF Antioxidant 2.0 0.8 4 Fogger 41 (continued) ESCALOL 507 UV absorber L, OO, 4211VINtlL 5 39 UV absorber 1.0 0.42 Silicone polymer 2.5 1.0 Improper Tools Volatile Solvent 10.0 4.25 Petroleum Distillate 8.0 3. 40 (Pyrethrum 7; from thin liquid) I place body/IIl! l gunpowder 63.5 27.83 (FIIEON 22) The test results in Table 2 demonstrate the effectiveness of the above formulation. For testing purposes, chisels Using five 720 cubic foot mobile home trailers . A second trailer was placed at intervals as a control.

Yu dog with brush Nomi no Sankichi (Trailer Nikki ΔKokari 1iff) Tatami’/”J-), Tgar’s lO Manning and processing 1 19.2 292.6 93.5 2 9.0 125.6 92.8 3 Counting and re-counting 10.6 35.0 69.74 133.0 27 8.4 52.27 Counting and re-counting 26.4 98.6 73.28 200.4 2B6.2 30.09 34.2 164.2 79.2 Grand Duke joins Yu This example describes the synthetic birethroids d-transallethrin and phenothrin. It shows a fogger based on The fogger processes 5000 cubic feet It is formulated to release at a rate of 6 oz/g.

Related compounds Insecticide 0.023 0.04 Phenothrin Insecticide 0.19 1 0.32 Related compounds “Insecticide 0.009 0.02 MGK264 Cooperation Agent 5.230 8.89p-7mi/benzoin FIUV absorbent 2.092 3. 56BHF Antioxidant 2.092 3.56 Silicone DC702 Polymer 0.052 0.09 Petroleum distillate 0.029 0.05 (from insecticide concentrate) Methylene dichloride volatile solvent 10.0 1? , 01 trichlorethylene volatilization Solvent 10.0 17.01 FREON22 Repellent/Carrier 69.982 119.04* Contained in equivalent commercial birethroid concentrates as previously noted. There is.

Stopping ± Construction This example illustrates the formulation of a shampoo according to the invention.

This special shampoo thoroughly cleanses the skin of dogs and cats, removing fleas, ticks, etc. Formulated to kill and prevent a variety of insect pests including maggots, lice, and lice. Ru. In fact, shampoo formulations were previously discussed for sprays, dips and powders. The same standards and ratios of silicone and pesticide content are followed. Shampoo action The shampoo base and water present are volatile as previously disclosed for sprays and dips. It acts as an inert diluent as well as a carrier. For previous applications of the invention, synthetic Viretroid can replace or be used in conjunction with pyrethrum.

Shampoo that is the embodiment of the present invention! ! ! In terms of production, the spray agent was used just before It includes the same steps as those described for manufacturing. To summarize, first, antioxidants. Dissolved in volatile solvents, then pesticides, synergists, repellents, LJV absorbers and silico Add all ingredients while stirring. Shampoo base is mixed separately and It is produced as a 7 dicondensate (for dilution with water) by a stirring and stirring step. insecticidal activity additives); the shrinkage product is concentrated into a shampoo base with constant stirring. Add slowly to the product. Squeezable bottle with airtight sealable outlet Transparent, suitable for use in storing and dispensing final products in double polyethylene containers Can be done.

Pyrethrum insecticide 0.15 Piperonyl butoxide synergist 1.50MGK264 synergist 0.50 MGK R11 repellent O,5O p-aminobenzoic acid UV absorber 1.50B) IF antioxidant 1.50 Silicone DC550 polymer 0.75 isopropanol volatile solvent 1 0. OO petroleum distillate (from pyrethrum notification thin material) 0.60 inert shampoo base Agent ° Placement 83.0 *Usual shampoo bases include deionized water, lauryl sulfate, Lium, Tea Lauryl Sulfate, Propylene Glycol USP.

Ethylene glycol monostearate, polyoxyethylene glycol, lanoli N, cocamide dea, quaternarium 19, EDTA (ethylenediamine tetraacetic acid), preservatives and F&C [1Iue ) Contains one constant color.

1lL (input) This final example shows another shampoo formulation according to the invention. This shade The compound is based on the synthetic birethroids d-) lancearethrin and permethrin. It is used as a drug.

Leaves and "Shiki Noh] J Shiichiretsu" - d-transalethrin insecticide 0 ．． 093 related compounds” Insecticides 0.007 Permethrin insecticide 0.15 MGK264 Synergist 1.50 MGK R326, self-avoidant 0.50 ESCALOL 507 U V absorber 0.20 [IVINUL 539 U V absorber 0.20BHF Antioxidant 0.50 Silicone DC702 Polymer 5.0 Petroleum Distillate (Insecticide? Q Thinning etc.) 0.34 Improper Tools Volatile Solvent 10.0 *Commercially available as previously described d-) Contained in lance arethrin concentrate.

All of it! 'l'T The examples described include active insecticide ingredients (pyrethrum, synthetic birethroid). and mixtures thereof) to enhance the effective insecticidal life of the 1 illustrates the idea of using liquid polymers.

Silicone is a non-volatile alkylaryl silicone, and its room temperature The volatility of phenylmethylporinloxa/liquid was expressed as DC550. to extremely low (in the range of 1 shot DC 710, the latter has a vapor pressure so low that 25 Cannot be measured at °C. The alkylaryl silicone of the present invention is preferably (, (,, class of molecules (e.g. DC550, 702, 704, 705, 710 and mixtures thereof).

Preferred silicone mixtures are modified to modulate the phenyl group Venus. can be done. In many embodiments, at least a phenyl group in alliance with a methyl group It should be noted that silicones (e.g. DC550) containing be. The clearly preferred low aerodynamic pressure of silicones is due to the common non-volatile components (e.g. Dimethyl chloride has a vapor pressure in the range of 0.1 to 2 mm Hg and is used as a repellent. It has a vapor pressure of several millionths of that of a crate.

Additionally, the present invention provides liquid halogenated alkylaryl silicones (e.g. For example, chlorophenylmethyl silicone oil or ethyl, propyl or butylphenyl higher alkylaryl silicones) such as silicone You can also do it. The selection of these silicones involves significant expense and for that reason they are Although these substances are not preferred, it is important to note that these substances are in the same molecular weight range and in relation to the examples. It is within the ideal scope of the present invention that it be used for the same purpose as described.

Finally, a mixture of alkylchlorosilane and phenylchlorosilane is reacted. Other silicones such as mixed polymers and copolymers made with These copolymers can be used for phenylchlorosilane starting materials. It has a varying phenyl group content depending on the molar ratio. The type of series described here Corn liquid is available from manufacturers, such as Dow Corning in the United States. (Doii Corning) and General Electric Company (Genera l Electric Company); These are also available from numerous manufacturers in Europe and Japan. Some of these manufacturers have varying phenyl content. mixed polymers or copolymers, e.g. Encyclopedia of Plus Encyclopedia of Plastics 25 mol% methane described on page 525 of It is described that the silicone liquid has a chlorophenyl group and has 15 mol% of a chlorophenyl group. Other silicone liquids listed. These liquids may be used in the present invention. is expected, and its volatility is on the order of DC550, while its solvent capacity is Due to the reduced content, the solvent capacity for active ingredients is not as great as that of DC550. do not have.

In addition to those originally listed, the following table lists other cases which may be desirable for use in the practice of the invention. Indicates adult biretroid, synergist, antioxidant, repellent, UV protectant and volatile carrier. vinegar. These tables are illustrative only and do not limit the practice of the invention to the specific ingredients shown. It's not something I try to do.

To Jubiretroid 1 (Two cars = 11 turns →) 2.2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylic acid ( 2-allyl-4-hydroxy-3-methyl-2-silyl Clopentene-1 ester 2,4-dimethylhensyl-2,2-dimethyl-3- (2-Methylpentyl)cyclopropanecarboxylate (dimethrine) 1- Cyclohexane-1,2-dicarboximidomethyl-2,2-dimethyl-3- (2-Methylpropenyl)-cyclopropanecarboxylate (tetra-metri ) 3-phenoxybenzyl-d-cis-transchrysanthemate (pheno 5-(phenylmethyl)-3-furanylmethyl-2,2-dimethyl-3 -(2-methyl-1-propenyl)cyclopropanecarboxylate (Resmet phosphorus) cyano-(3-phenoxyphenyl)methyl-4-chloro-alpha(l -Methyl ethyl henzene acetate (fenvalerate) 3-phenoxyphenylmethyl-(+)-cis-trans-3-(2,2-dic loloethynyl)-2,2-dimethylcyclopropanecarboxylate (permeth)-2,2-dimethylcyclopropanecarboxylate phosphorus)(+)-cyano-(3-phenoxyphenyl)methyl(+)-cis-tra ence 3 (2,1-dichloroethynyl)-2,2-dimethylcyclopropanecar Boxylate (shibarmethrin) Alphacyano-3-phenoxyhensyl-d, cissudispromochrysante Mate (deltamethrin)cyano (4-fluoro-3-phenoxyphenyl ) Methyl-3-(2,2-dichloroethynyl)-2,2-dimethylcyclopropyl carboxylate Seed Roof J Ishi L1 Zhang Works January Light Q Spot piperonyl butoxide N-octyl-bicyclohebutene dicarboximide octyl thiocyanate, Such as nil thiocyanate, denyl thiocyanate and undecyl thiocyanate. The unao functional group is an organic group, which is a long chain aliphatic organic group having 8 to 14 carbon atoms. oceanate Octachlorodipropyl ether Monthly Decadal λA 2.3: 4.5-bis(2-butylene)tetrahydro-2-furaldehyde but xypolypropylene glycol N,N'-diethyltoluamide 2-Hydroxyethyl-〇-octyl sulfide dimethyl phthalate D-n-probyl isocincomelonate Butylated hydroxytoluene BHT tert-butylhydroquinone (TBHQ) phytylated hydroxyanisole (BH8) Ethoxyquin ascorbic acid Ascorbic acid inorganic salt Ascorbinocbalmitate Inorganic salts of propionic acid (e.g. propyl gallate, thiodipropionic acid, thiodipropionate) Lil) Medical treatment for 1 day octyldimethyl-aminobenzoate 2-ethylhexyl-2-cyano-3, 3'-diphenylacrylate 2-ethylhexyl-p-dimethylaminobenzoate 2.2'-dihydroxy -4,4'-dimethoxy-5,5-disulfohensephenone 2-hydroxy-4 -methoxopenzophenone-5-sulfonic acid 2, 2', 4. 4', Tetrahydroxyhensophenonephenyl salicy rate 2-(2H-hensitriazol-2-=.yl)-p-cresol 2-ethoxy Ethyl-p-methoxycinnamate p-aminobenzoic acid (PABA)- Limit 2-1 player's trouble Ituburobanol, ethanol, acetin, isobutyl alcohol, methanol Brief description of Le, methyl ethyl ketone, methylene chloride drawings International v4 mutual report

Claims (1)

[Claims] 1. an insecticide selected from the group consisting of pyrethrum, synthetic viretroid and mixtures thereof; a synergist for said insecticide in an amount effective to provide immediate insecticidal action; and said insecticide. Essentially 25% of the antioxidant content is sufficient to protect the product from oxygen degradation. An aqueous solution that is liquid at ℃ and has a solvent effect on the insecticides, synergists and antioxidants. and a soluble alkylaryl silicone liquid, the silicone liquid containing the insecticide. It is characterized by being present in the range of about 1:10 to about 260:1 in parts by weight with respect to the agent. Best side composition for killing insects. 2. The silicone liquid has at least the same number of phenyl groups as methyl groups. 2. A composition according to claim 1, comprising methylsilicone. 3. The silicone liquid has 50% phenyl groups and 50% dimethyl groups. , a linear siloxane polymer in which phenyl groups and methyl groups are present in the side chains in equal molecular proportions. The composition according to claim 2, which is a remer. 4. 4. The silicone liquid of claim 3, wherein the silicone liquid has a molecular weight of about 750. Composition. 5. Claims wherein the silicone liquid comprises a phenylmethyltrisiloxane liquid. Composition according to item 1. 6. The liquid contains about 44% phenyl groups, about 56% methyl groups, and about 2600 molecules. 6. A composition according to claim 5, comprising: 7. The silicone liquid is phenylmethylcyclosiloxane and dimethylcyclosiloxane. A composition according to claim 1, comprising a siloxane. 8. The silicone liquid may contain tetramethyltetraphenyltrisiloxane. The composition according to claim 1. 9. Claims wherein said silicone liquid comprises bentaphenyltrimethylsiloxaso. A composition according to scope 1. 10. The synergist is piperonyl butoxide, n-octylbicycloheptenedica. Claimed in claim 1 selected from the group consisting of ruboximide and mixtures thereof. composition. 11. The ratio of insecticide to synergist should be about 1:5 to 1:50 parts by weight. The composition according to claim 1. 12. Claim 1, wherein the antioxidant comprises butylated hydroxytoluene. composition. 13. The ratio of insecticide to antioxidant is about 1:10 to about 1:1 parts by weight. The composition according to claim 1. 14. Further, a UV protectant soluble in the silicone liquid is added to the insecticide in the UV light. 2. The composition of claim 1, comprising an amount effective to protect the composition from disintegration caused by. 15. The UV protectant is p-aminobenzoic acid, 2-ethyl-hexyl-p-di Methylaminobenzoate, 2-ethylhexyl-2-cyano 3,3'-diph Claim 1 selected from the group consisting of phenyl arylate and mixtures thereof. Composition according to item 4. 16. The ratio of insecticide to UV protectant is about 1:1 to about 1:10 parts by weight. 15. The composition according to claim 14. 17. The silicone-soluble pest repellent is applied to the substrate to be treated with the composition. claim 1 containing an amount effective to inhibit re-infestation by insect pests after use; Composition according to item 1. 18. The repellent is di-n-propylisocincomeronate, 2,3,4,5- Bis(2-butylene)-tetrahydro-2-furaldehyde and mixtures thereof 18. The composition according to item 17, selected from the group consisting of: 19. Claimed wherein the ratio of insecticide to repellent is from about 1:4 to about 120 by weight. A composition according to scope item 17. 20. Claim 17, comprising from about 0.25% to about 5% by weight of said repellent. Composition of. 21. Volatile carrier for said pesticides, synergists, antioxidants and silicone liquids for use on animals and plants as a liquid containing an effective amount to dissolve them; A composition according to claim 1. 22. The carrier is isopropanol, ethanol, aqueous emulsion, and mixtures thereof. 22. A composition according to claim 21 selected from the group consisting of: 23. The insecticide, synergist, antioxidant and silicone liquid are coated thereon. Claims for application as a powder containing a fine granular solid carrier Composition according to item 1. 24. 24. The composition of claim 23, wherein the solid carrier comprises silica gel. 25. Inert repellent carrier for said insecticides, synergists, antioxidants and silicone liquids A composition according to claim 1 for application as a fogger comprising: 26. Inert as a carrier for said insecticides, synergists, antioxidants and silicone liquids. Claim 1 for application to animals in the form of a shampoo containing a shampoo base The composition described in . 27. The silicone liquid is about 15 to about 20 parts by weight to the insecticide. A composition according to claim 1, wherein the composition is present in a proportion of . 28. pyrethrum, synthetic viretroid and mixtures thereof; an insecticide, a synergist for said insecticide effective to give immediate insecticidal action, and said insecticide; an antioxidant in an amount effective to protect the pesticide from degradation by oxygen; an amount of a UV protectant effective to protect against UV degradation and essentially permanently It is liquid at 25°C and is soluble in the above insecticides, synergists, antioxidants and UV protectants. A water-insoluble alkylaryl silicone polymer having mediating properties, The corn polymer is in a ratio of about 1:10 to about 260:1 parts by weight to the insecticide. and a volatile carrier for all of the above components. Best side liquid for application to animals and plants for live insects. 29. Additionally, a silicone-soluble insect repellent is applied to the substrate to be treated with the composition. Claim 28 includes an amount effective to inhibit pest repopulation after application. Compositions as described. 30. The repellent is di-n-propylisocincomeronate, 2,3,4,5- Bis(2-butylene)-tetrahydro-2-furaldehyde and mixtures thereof A composition according to claim 29 selected from the group consisting of. 31. The synergist, ultraviolet protectant and antioxidant are insecticides against them in parts by weight. 29. A composition according to claim 28, wherein the composition is present in the following ratios: Insecticide: Synergist - about 1:5 to about 1:50 Insecticide: Antioxidant - about 1:1 to about 1:1 0 insecticide: ultraviolet absorber - about 1:1 to about 1:1032. Contains insect repellents and insecticides Claim 31, wherein the ratio of the repellent to the repellent is about 1:4 to about 1:20 parts by weight. The composition described in Section. 33. Claim 31 comprising an insect repellent in an amount of about 0.25% to about 5% by weight. Compositions as described. 34. Claims wherein the silicone polymer comprises a phenylmethylsiloxane liquid. A composition according to paragraph 28. 35. Claim 3: The liquid has at least the same number of phenyl groups as methyl groups. Composition according to item 4. 36. The liquid has 50% phenyl groups and 50% dimethyl groups, It is a linear siloxane polymer in which methyl groups and side chains are present in equal molecular proportions. The composition according to claim 35. 37. The siloxane polymer is monomolecular and has a molecular weight of about 750. The composition according to claim 36. 38. The claim that the silicone polymer comprises a phenylmethyltrisiloxane liquid The composition according to item 28. 39. The liquid has a molecular weight of about 2600, about 44% phenyl groups and about 56% phenyl groups. 39. The composition of claim 38, comprising % methyl groups. 40. The silicone polymer is phenylmethylcyclosiloxane and dimethyl 29. The composition of claim 28 comprising a mixture of cyclosiloxanes. 41. The silicone polymer contains tetramethyltetraphenyltrisiloxane. 29. The composition of claim 28 comprising: 42. The silicone polymer contains pentaphenyltrimethyltrisiloxane. 29. The composition according to claim 28. 43. The UV protectant is p-aminobenzoic acid, 2-ethylhexyl-p-dimetri thylaminobenzoate, 2-ethylhexyl-2-cyano-3,3'-dife Claim 28 selected from the group consisting of nyl arylate and mixtures thereof. The composition described in Section. 44. Claim 28, wherein the antioxidant comprises butylated hydroxytoluene. Compositions as described. 45. The synergist is piperonyl butoxide, n-octylbicycloheptenedica. as claimed in claim 28, selected from the group consisting of ruboxides and mixtures thereof. composition. 46. The silicone polymer is added in a proportion of about 1:5 to about 20 parts by weight based on the insecticide. 29. A composition according to claim 28, wherein the composition is present in a ratio of :1.