JP2003095813A - Liquid agent for expelling exoparasite of animal - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an agent for expelling exoparasites of animals keeping the expelling effect over a long period. SOLUTION: Exoparasites of animals can be expelled over a long period by mixing an insecticide effective against exoparasites, an antioxidant and an oily solvent and dropping the produced solution on the back of the animal.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to the control of ectoparasites of animals, such as pets of dogs, cats, cattle, pigs, chickens, etc. It relates to liquid medicines.

[0002]

2. Description of the Related Art Generally, harmful skin fleas, mites and other harmful arthropods are often infested on the skin of animals, and such parasitism of harmful arthropods may cause a decrease in animal immunity and deterioration of physical strength. It becomes more severe, and there is a high probability that it will be infected with various pathogens and will die of illness. In addition, when fleas and ticks parasitize companion animals that live in the same environment as humans, the feeling of cleanliness is lost and there is a sanitary problem. Therefore, various ectoparasite control agents have been used conventionally, but in recent years, parasites have been prepared by dropping a solution of an ectoparasite-killing insecticide in a solvent onto the back of an animal or the like. Methods for exterminating or preventing parasitism have been proposed.

[0003]

The method of dropping the solution containing the insecticide onto the back of an animal is a very simple method, but the problem remains in terms of the sustainability of the effect.

[0004]

Means for Solving the Problems The present inventor has conducted earnest research for the purpose of solving the above-mentioned problems. As a result, a mixture of an insecticide having an insecticidal effect on an ectoparasite and an antioxidant, and a mixed liquid preparation The present invention has been completed by discovering that the problem can be solved by dropping a solution in which these components are preferably mixed with an oily solvent onto the back of an animal or the like.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION As an animal to which the liquid composition for controlling ectoparasites of the present invention is applied, various animals such as livestock, poultry, pets, etc., to which humans are raised, particularly animals such as mammals and birds. More specific examples include pets such as dogs and cats, livestock such as cattle, horses, pigs and chickens, and poultry.

The insecticide used in the present invention is a compound having an insecticidal effect on ectoparasites parasitizing animals such as dog fleas, cat fleas and ticks, and examples thereof include pyrethroid compounds. Examples of pyrethroid compounds include allethrin, phenothrin, permethrin, cyphenothrin,
Transfluthrin, bifenthrin, etofenprox, silafluofen, cyfluthrin, cyhalothrin, pralethrin, cypermethrin, fenpropatrine, tralomethrin, deltamethrin and the like,
In addition, pyrethrum extract containing pyrethrin and the like is also added. Furthermore, use of allethrin, pyrethrin, phenothrin, permethrin, transfluthrin, and etofenprox is more preferable.

Examples of the compound having an insecticidal effect on the ectoparasites include neonicotinoid compounds such as nitenpyram and acetamiprid, phenylpyrazole compounds, phenylpyrrole compounds such as chlorophenapyr, and organophosphorus compounds such as fenitrothion and fenthion. Can also be mentioned.

An insect growth regulator is also added as a compound having an insecticidal effect on the ectoparasites. Although insect growth regulators do not have the effect of immediately dying adults, they act in the same way as insecticides in the sense that the purpose of exterminating parasites from the surface of the animal body is achieved by the growth inhibition effect of larvae. Is shown. Examples of insect growth regulators include
Pyriproxyfen, juvenile hormone-like compounds such as methoprene, diflubenzuron, triflumuron, rufenuron, chitin formation-inhibiting compounds such as teflubenzuron, anti-juvenile hormone-like compounds, molting hormone-like compounds, and the like, in particular, pyriproxyfen, The use of methoprene is preferred.

The compounds having an insecticidal effect on the ectoparasites may be used alone or in combination of two or more.

Although there are various stereoisomers of the compound having an insecticidal effect on the ectoparasites, any active stereoisomer or a mixture thereof is used in the present invention.

As the antioxidant used in the present invention,
For example, dibutylhydroxytoluene (abbreviated as BHT), butylhydroxyanisole (abbreviated as BHA), 4,4′-thiobis (3-methyl-6-t-).
Butylphenol) (abbreviated as TBMTBP) and the like, and the use of BHT is preferable.

Examples of the oily solvent used in the present invention in which the compound having an insecticidal effect on the ectoparasite and the antioxidant are mixed are, for example, diethylene glycol monoethyl ether, diethylene glycol monomethyl ether, propylene glycol, dipropylene glycol, Examples include tripropylene glycol, ethanol, propylene carbonate, benzyl alcohol, kerosene, and soybean oil, coconut oil, palm oil, linseed oil, cottonseed oil, rapeseed oil, tung oil, castor oil, olive oil, rice bran oil, if necessary. Vegetable oils and essential oils such as are also used.

The liquid composition for controlling ectoparasites of the present invention is usually
If the compound having an insecticidal effect on the ectoparasite is 1 to 50% by weight, and the compound having an insecticidal effect on the ectoparasite is an insect growth controlling compound, the insect growth controlling compound is 0.01 to
It is preferable to contain 5% by weight.

Antioxidants in the context of the present invention usually have a pH of 0.
001 to 5% by weight, preferably 0.01 to 1% by weight is added to the ectoparasiticidal solution of the present invention.

Examples of the ectoparasites to be exterminated by the liquid agent for controlling ectoparasites of the present invention include fleas such as dog fleas, cat fleas and human fleas, ticks such as ticks, tsutsugamushi, oribatid mites, and mites. To be Further, in the present invention, ectoparasites include those that do not always live on the surface of the body of animals like mosquitoes, but are harmful by blood-sucking from the body surface of animals.

Further, the liquid agent for controlling ectoparasites of the present invention may contain a fragrance, a spreading agent, a synergist and the like. Examples of the synergist include N- (2-ethylhexyl)-
1-isopropyl-4-methylbicyclo [2.2.2]
Oct-5-ene-2,3-dicarboximide, N-
(2-Ethylhexyl) bicyclo [2.2.1] hept-5-ene-2,3-dicarboximide (MGK-2)
It is abbreviated as 64. ), Isobornyl thiocyanoacetate (abbreviated as IBTA), piperonyl butoxide (abbreviated as PBO), and the like.

The liquid composition for controlling ectoparasites of the present invention is usually
It is applied by dripping on the body surface of an animal.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the examples.

[0019]

[Formulation Example] 40 parts of d-phenothrin, 0.04% of BHT
To prepare a liquid agent in which was dissolved in diethylene glycol monoethyl ether.

[0020]

[Comparative formulation] A liquid formulation was prepared by dissolving 40 parts of d-phenothrin in diethylene glycol monoethyl ether.

[0021]

[Examples] To a cat (French domestake, 2 years old, female, body weight 3 kg), the ectoparasite control liquid preparations of the above-mentioned formulation examples and comparative formulation examples were directly dripped on the skin by scraping back the cat's back coat. The dropping was performed by dividing 1.5 ml of the above liquid agent into 3 equal parts and using 3 droppers. One day later, one week later, two weeks later, three weeks later, and four weeks later, the cat treated with the above liquid preparation had 3 adult cat fleas per cat.
0 animals were inoculated. Three days after each inoculation, cat hair was combed using a flea comb, the number of flea picked was counted, the number of cat flea infestations was investigated, and the extermination rate was calculated by the following formula.

The test results of the examples are shown in Table 1.

【table 1】

As is clear from Table 1, the ectoparasite control solution of the present invention can effectively control fleas over a long period of time as compared with the comparative formulation example.

[0024]

EFFECTS OF THE INVENTION By using the ectoparasite control liquid of the present invention, ectoparasites of animals can be eradicated reliably for a long period of time.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A01N 53/08 A61K 9/08 A61K 9/08 31/215 31/215 31/40 31/40 31/415 31/415 31/44 31/44 31/4402 31/4402 31/661 31/661 45/00 45/00 47/10 47/10 A61P 33/14 A61P 33/14 A01N 53/00 508A F term (reference) ) 4C076 AA11 BB34 BB36 CC34 DD37 FF12 FF68 4C084 AA17 AA27 CA59 CA62 MA01 MA05 MA17 NA05 NA10 NA12 ZB37 4C086 AA01 AA02 BC05 BC17 BC36 DA34 MA05 MA17 MA63 NA05 NA07 NA01 NA37 MA12 NA01 NA10 NA12 NA01 NA37 MA12 NA01 NA10 NA12 NA01 NA12 NA01 BB09 BB11 BB15 BC03 DA12 DD07

Claims (13)

[Claims] 1. A liquid agent for controlling ectoparasites of animals, which comprises an insecticide and an antioxidant. 2. A liquid agent for controlling ectoparasites of animals, which comprises an insecticide, an antioxidant and an oily solvent. 3. The liquid agent for controlling ectoparasites of animals according to claim 1, wherein the insecticide is a pyrethroid compound. 4. The liquid agent for controlling ectoparasites of animals according to claim 1, wherein the pyrethroid compound is allethrin, pyrethrin, phenothrin, permethrin, transfluthrin, or etofenprox. 5. The liquid agent for controlling ectoparasites of animals according to claim 1 or 2, wherein the insecticide is a neonicotinoid compound. 6. The liquid agent for controlling ectoparasites of animals according to claim 1 or 2, wherein the insecticide is a phenylpyrazole compound. 7. The liquid agent for controlling ectoparasites of animals according to claim 1, wherein the insecticide is a phenylpyrrole compound. 8. A liquid agent for controlling ectoparasites of animals according to claim 1 or 2, wherein the insecticide is an organic phosphorus compound. 9. The liquid agent for controlling ectoparasites of animals according to claim 1, wherein the insecticide is an insect growth regulator. 10. The insect growth regulator is pyriproxyfen,
The liquid agent for controlling ectoparasites of animals according to claim 1, 2 or 9, which is methoprene. 11. The liquid agent for controlling ectoparasites of animals according to claim 1, wherein the antioxidant is dibutylhydroxytoluene. 12. A method for controlling ectoparasites of an animal, which comprises dropping a mixed solution of an insecticide and an antioxidant onto the animal. 13. A method for controlling ectoparasites of an animal, which comprises dropping a mixed solution of an insecticide and an antioxidant into an oily solvent to the animal.