JP2006213616A - Animal ectoparasite expelling agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an expelling agent capable of being spread on a body surface of an animal and then closely coming into contact with the surface in a wide surface area, when applied to the body surface of the animal, and therefore capable of effectively expelling an animal ectoparasite. <P>SOLUTION: This animal ectoparasite expelling agent contains an animal ectoparasite expelling substance and a silicone. A content the silicone depends on a kind of the silicone, but it is preferable that the silicone is contained in the expelling agent in an amount of 0.01-50.0 wt%. The silicone is more preferably contained in an amount of 0.1-40.0 wt%. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an animal ectoparasite control agent, and more particularly to an animal ectoparasite control agent that is suitable for application to animal body surfaces such as pets and livestock to control animal ectoparasites.

  Conventionally, as a treatment method for controlling ectoparasites such as fleas, lice pests and mite pests that harm domestic animals and domestic animals such as pets, a pesticide is applied to the body surface of the animal. Treatment methods called spot-on and pour-on to be applied are known, and these methods are often used for controlling such ectoparasites because of their simple treatment.

In the spot-on treatment and the pour-on treatment, the control agent applied to the animal body surface is required to spread and come into close contact with the animal body surface with a large surface area. For example, Patent Document 1 proposes a pour-on anthelmintic composition containing isopropyl myristate or the like as a spreading agent. However, the spread of the composition is not always sufficient, and the present situation is that the spread is not always sufficient for other animal ectoparasite control agents.
JP-A-62-51932

  The present invention is intended to solve the above-mentioned problems, and the object thereof is to apply to a body surface of an animal so that it can expand and come into close contact with the body surface of the animal with a large surface area. An object of the present invention is to provide a control agent that can effectively control ectoparasites.

  As a result of intensive studies on the above problems, the present inventors have used silicone as a spreading agent and applied a control agent containing the same to the body surface of the animal, thereby spreading the animal with a large surface area. It has been found that it can come into close contact with the body surface and therefore can effectively control ectoparasites of animals, and the present invention has been completed.

  That is, the present invention suitable for the above object is an animal ectoparasite control agent characterized by containing an animal ectoparasite control substance and silicone.

  Claim 2 is that in the above invention, the silicone is at least one selected from dimethyl silicone oil, highly polymerized dimethyl silicone oil, cyclic silicone oil, polyether-modified silicone oil, amino-modified silicone oil, and methylphenyl silicone oil. Features.

  A third aspect of the present invention is characterized in that the silicone content is 0.01 to 50.0% by weight in the control agent.

  In claim 4, the animal ectoparasite control substance of the invention according to claim 1 is a pyrethroid compound, organophosphorus compound, carbamate compound, chitin formation inhibitor, juvenile hormone-like substance, animal endoparasite control substance, pest repellent It is at least one selected from active substances and other insecticidal components, and claim 5 is the case where the content of the animal ectoparasite control substance is the content of the insect growth control active compound in the control substance. Is 0.001 to 10.0% by weight, and 0.01 to 80.0% by weight in the case of other control substances excluding insect growth control active compounds.

  Claims 6 and 7 are treatment modes of the animal ectoparasite control agent of the present invention, wherein claim 6 is for spot treatment and claim 7 is for pour-on treatment, respectively.

Since the animal ectoparasite control agent of the present invention contains silicone as a spreading agent,
When applied to the animal body surface by spot-on treatment or pour-on treatment, it spreads sufficiently so that it can be in close contact with the animal body surface with a large surface area, thus effectively controlling the ectoparasites of the animal. .

  Hereinafter, specific embodiments of the present invention will be described in detail.

  The ectoparasite control agent for animals of the present invention (hereinafter simply referred to as control agent) basically contains an ectoparasite control substance for animals as an active ingredient and silicone as a spreading agent as described above. It is.

  The animal ectoparasite control substance used in the present invention is not particularly limited, and known substances can be used. Specifically, for example, permethrin, phenothrin, allethrin, d-arethrin, pyrethrin, praretrin, ciphenothrin, cyfluthrin, fenvalerate, fenpropatoline, transfluthrin, resmethrin, empentrin, cyhalothrin, etofenprox, tralomethrin, effy Pyrethroid compounds such as biosulin, terrareslin, profluthrin, and metfurthrin, dichlorvos, tetrachlorobinphos, fenthion, chlorpyrifos, diazinon, fenitrothion, nared, siaphos, calcrophos, salicion and other organic phosphorus compounds, propoxur, carbaryl, methoxadiazone, BPMC, etc. Carbamate compounds, lufenuron, chlorfluazuron, hexaflumuron, diflubenzuron, white Gin, triflumuron, teflubenzuron, flufenoxuron, fluazuron, triazuron, 1- (2,6-difluorobenzoyl) -3- [2-fluoro-4- (1,1,2,3,3,3-hexafluoro Propoxy) phenyl] urea and other chitin formation inhibitors, pyriproxyfen, metoprene, hydroprene, juvenile hormone-like substances such as phenoxycarb, animal endoparasite control agents such as milbemycin, abamectin, irbemectin, Diet, limonene, linalool , Citronellal, menthol, menthol, hinokitiol, geraniol, eucalyptus, indoxacarb, caran-3,4-diol, orange, citronella, lemon, lemongrass, cinnamon, peppermint, mint, hyssop, tea tree, anise Star anise, thymol, eugenol, thyme white, garlic, clove, pimento, columnus, cinnamon leaf, cahiyu, cinnamaldehyde, fernwood, casscha, spearmint, hiba, petalaldehyde, santalol, etc. Examples of the insecticidal component include allyldiazole compounds, neonicotinoid compounds such as acetamiprid, nitenpyram, thiacloprid, and thiamethoxam, phenylpyrazole compounds such as fipronil, and 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide. These may be used alone or in combination of two or more. Of these animal ectoparasite control substances, insect growth control active compounds such as chitin formation inhibitors and juvenile hormone-like substances are particularly preferably used.

  The content of the animal ectoparasite control substance depends on the type of animal ectoparasite control substance, but the insect growth control active compound such as a chitin formation inhibitor and a juvenile hormone-like substance in the control solution of the present invention. 0.001 to 10.0% by weight, 0.01 to 80.0% by weight is preferable for other control substances excluding the insect growth control active compound, more preferably 0.01 to 10.0% for the insect growth control active compound. % By weight, 0.1-70.0% by weight for other control substances except insect growth control active compounds.

  The control agent of the present invention can exert its control effect more effectively by containing a synergist together with the animal ectoparasite control substance. The synergist that can be used in the present invention is selected according to the type of animal ectoparasite control substance, and examples thereof include PBO, S421, MGK264, IBTA, and sinepirin 500.

  The silicone used in the present invention is not particularly limited. For example, dimethyl silicone oil, highly polymerized methyl silicone oil, cyclic silicone oil, polyether-modified silicone oil, amino-modified silicone oil, methylphenyl silicone oil, etc. These may be used alone or in combination of two or more.

  Although content of said silicone is based also on the kind of silicone, 0.01-50.0 weight% is preferable in the control agent of this invention, More preferably, it is 0.1-40.0 weight%. If the silicone content is less than 0.01% by weight, the spreading effect of the control agent of the present invention may be inferior. On the other hand, if it exceeds 50.0% by weight, it will spread too much for use. Since it may occur, it is not preferable.

  In addition to the above, the control agent of the present invention can be used by dissolving in a solvent if necessary. The solvent is not particularly limited. For example, alcohols such as methyl alcohol, ethyl alcohol, isopropyl alcohol, phenoxyethanol, and benzyl alcohol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, hexylene glycol, and the like Glycols, ethylene glycol dimethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, propylene glycol monomethylene ether, ethers such as 3-methoxy-3-methyl-1-butanol, propylene carbonate, 2-pyrrolidone, N-methyl- Alkylpyrrolidones such as 2-pyrrolidone, xylene, toluene, alkylnaphthalene, Nyloxysilylethane, kerosene, light oil, hexane, cyclohexane, liquid paraffin, liquid isoparaffin, light liquid paraffin and other aromatic or aliphatic hydrocarbons, chlorobenzene, dichloromethane, trichloroethane and other halogenated hydrocarbons, ethyl acetate, acetic acid Esters such as butyl and ethyl lactate, oxyacid esters such as triethyl citrate, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone, nitriles such as acetonitrile and isobutyronitrile, dimethyl sulfoxide, N, N -Acid amides such as dimethylformamide, vegetable oils such as soybean oil and cottonseed oil, plant essential oils such as orange oil, hyssop oil and lemon oil, and water. These solvents may be used alone or in combination of two or more. These are used in an appropriate ratio in the control agent depending on the type of the control agent.

  In addition to the animal ectoparasite control substance, silicone and solvent, the control agent of the present invention may further contain other additives as necessary, for example, BHT, BHA, tocopherol acetate, tocopherol, etc. Antioxidants, emulsifiers such as sorbitan monooleate, sorbitan monolaurate, caprylic acid monoglyceride, capric acid monoglyceride, isostearic acid monoglyceride, propylene glycol monocaprylate, and the like, and the like.

  The control agent of the present invention is usually applied to animals by a local treatment method such as spot-on treatment or pour-on treatment, whereby the ectoparasites of the animal can be efficiently controlled. The spot-on treatment method is a method of controlling ectoparasites by dropping a liquid ectoparasite control agent on the skin of the back of the scapula of an animal body and spreading the control agent. The pour-on treatment method is a method of controlling ectoparasites by pouring a liquid ectoparasite control agent along the back line of the animal body and spreading the control agent.

  The application amount of the control agent of the present invention to animals is usually about 0.2 to 8.0 ml per animal to be applied, but can be increased or decreased as appropriate.

  The ectoparasites that can be effectively controlled by the control agent of the present invention are ectoparasites of domestic animals such as cattle and sheep and pets such as dogs and cats. The ectoparasites mentioned here include not only those that always live on the surface of the animal's body, but also pests that cause harm by sucking blood from the animal's body surface and licking body fluids even if they do not always live . For example Noiebae (Musca hervei), Kuroiebae (Musca bezzii), the horn fly (Heamatobia irritans), Tsumetogebuyu (Simulium iwatens), Ushinukaka (Culicoides), gadfly (Tabanus trigonus), Culex (Culex pipiens pallens), Aedes albopictus (Aedes albopictus), such as Dipterous pests, lice of lice (Haematopinus eurasternus), lice of the lice of sheep (Damalinia), tick ticks (Haemaphyxalis longicornis), tick (Boophilus ternecous) lis), pests such as Cenocephalides canis and Xenopsilla cheopes. The target animals to which the control agent of the present invention is applied include, for example, rodents such as mice, rats, hamsters, and squirrels, carnivores such as rabbits and ferrets, and ducks. , Birds such as chickens and pigeons.

  As described above, since the control agent of the present invention contains silicone as a spreading agent, it spreads sufficiently when spot-on treatment or pour-on treatment is applied to the body surface of the animal, and the animal has a large surface area. It can be in close contact with the body surface and thus can effectively control ectoparasites of animals.

  EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples.

Examples First, compositions according to the present invention were obtained according to the following Formulation Examples 1 to 9.
Formulation Example 1
Phenothrin 20.0 W / V%, d-aresulin 2.0 W / V%, pyriproxyfen 0.8 W / V%, cyclic silicone oil 5.0 W / V%, BHT 0.5 W / V%, diethylene glycol monoethyl ether Was added to make 100 W / V%, and this was mixed to obtain the composition of the present invention.
Formulation Example 2
Phenothrin 20.0 W / V%, d-aresulin 2.0 W / V%, pyriproxyfen 0.8 W / V%, methylphenyl silicone oil 5.0 W / V%, BHT 0.5 W / V% and diethylene glycol monoethyl ether Was added to make 100 W / V%, and this was mixed to obtain the composition of the present invention.
Formulation Example 3
Phenothrin 20.0 W / V%, d-aresulin 2.0 W / V%, pyriproxyfen 0.8 W / V%, cyclic silicone oil 2.5 W / V%, methylphenyl silicone oil 2.5 W / V%, BHT0 The composition of the present invention was obtained by adding diethylene glycol monoethyl ether to 0.5 W / V% to 100 W / V% and mixing this.
Formulation Example 4
Diethylene glycol monoethyl ether was added to phenothrin 20.0 W / V%, metfurthrin 2.0 W / V%, pyriproxyfen 0.8 W / V%, cyclic silicone oil 5.0 W / V%, BHT 0.5 W / V% The composition of the present invention was obtained by mixing 100 W / V%.
Formulation Example 5
Diethylene glycol monoethyl ether was added to phenothrin 20.0 W / V%, metfurthrin 2.0 W / V%, pyriproxyfen 0.8 W / V%, cyclic silicone oil 5.0 W / V%, BHT 0.5 W / V% The composition of the present invention was obtained by mixing 100 W / V%.
Formulation Example 6
Phenotrin 20.0W / V%, Metofluthrin 2.0W / V%, Pyriproxyfen 0.8W / V%, Cyclic silicone oil 2.5W / V%, Methylphenyl silicone oil 2.5W / V%, BHT 0.5W The composition of the present invention was obtained by adding diethylene glycol monoethyl ether to / V% to 100 W / V% and mixing this.
Formulation Example 7
Diethylene glycol monoethyl ether is added to Etofenprox 20.0 W / V%, Pyriproxyfen 0.8 W / V%, Cyclic silicone oil 5.0 W / V%, BHT 0.5 W / V%, and 100 W / V% The composition of the present invention was obtained by mixing these.
Formulation Example 8
Diethylene glycol monoethyl ether is added to etofenprox 20.0 W / V%, pyriproxyfen 0.8 W / V%, methylphenyl silicone oil 5.0 W / V%, BHT 0.5 W / V%, and 100 W / V %, And this was mixed to obtain the composition of the present invention.
Formulation Example 9
Etofenprox 20.0W / V%, pyriproxyfen 0.8W / V%, cyclic silicone oil 2.5W / V%, methylphenyl silicone oil 2.5W / V%, BHT 0.5W / V%, diethylene glycol Monoethyl ether was added to give 100 W / V%, and this was mixed to obtain the composition of the present invention.

Next, the comparative composition was produced | generated by the comparative examples 1-3 corresponding to the formulation example in the said Example.
Comparative Example 1
Compositions were obtained from Examples 1, 2, and 3 from which silicone oil was removed. Diethylene glycol monoethyl ether was added to phenothrin 20.0 W / V%, d-arethrin 2.0 W / V%, pyriproxyfen 0.8 W / V%, and BHT 0.5 W / V% to obtain 100 W / V%. .
Comparative Example 2
Compositions were obtained from Examples 4, 5 and 6 excluding silicone oil. Diethylene glycol monoethyl ether was added to phenothrin 20.0 W / V%, metfurthrin 2.0 W / V%, pyriproxyfen 0.8 W / V%, and BHT 0.5 W / V% to obtain 100 W / V%.
Comparative Example 3
Compositions were obtained from Examples 7, 8 and 9 excluding silicone oil. Diethylene glycol monoethyl ether was added to etofenprox 20.0 W / V%, pyriproxyfen 0.8 W / V%, and BHT 0.5 W / V% to obtain 100 W / V%.

Thus, the aspect and result which tested the composition by the preparation examples 1-9 based on implementation of the said said invention and the composition by the comparative examples 1-3 by comparison are shown.
Test example 1
The composition of the present invention obtained in accordance with Formulation Examples 1 to 9 and the composition obtained in accordance with Comparative Examples 1, 2 and 3 were placed in a micropipette on the back of the neck of a mouse (biological weight 30 g) with a micropipette. After coating, the mouse was placed in a bag-like wire mesh and fixed in a container. Then, 30 cat flea adults (Ctenocepghalides felis) were placed in this container, and the number of fleas dropped by the mice 3 hours after the release was observed to determine the dropout rate. As a control, mice not treated with the drug were subjected to the test in the same procedure. The test was repeated three times. The results of Test Example 1 are shown in Table 1.

試験例２
製剤例１から９に準じて得られた本発明組成物、ならびに比較例１，２および３に準じて得られた組成物を用いて以下の試験を行った。
駆除効果試験
ネコ(雑種、３才から５才、雄、体重４〜５ｋｇ)に１頭当たり５０匹のネコノミ成虫を寄生させて順化させた後、製剤例１，４及び７に準じて得られた本発明組成物、ならびに、比較例１，２および３に準じて得られた組成物を各々、ネコの頭背部の２箇所の被毛を掻き分けて皮膚に直接滴下した。滴下量は１．２ｍｌとし、マイクロピペットにて各々の組成物を２等分し滴下処理した。

Test example 2
The following tests were conducted using the compositions of the present invention obtained according to Formulation Examples 1 to 9 and the compositions obtained according to Comparative Examples 1, 2, and 3.
Exterminating effect test Cats (mongrel, 3-5 years old, male, body weight 4-5 kg) were infested with 50 cat flea adults per head and acclimatized, and obtained according to Formulation Examples 1, 4 and 7. The obtained composition of the present invention and the compositions obtained according to Comparative Examples 1, 2, and 3 were each dropped directly on the skin by scraping the two coats of the cat's head and back. The amount dropped was 1.2 ml, and each composition was divided into two equal parts with a micropipette and dropped.

Two test cats were prepared per drug, and the number of parasites was examined one by one 24 hours after drug treatment. The extermination rate was calculated | required by the following formula from the obtained number of parasitics.

  The results of the above test examples are shown in Table 2.

上記表１，表２の結果より本発明による動物用外部寄生虫防除剤はシリコーンを拡展剤として用いたことにより、拡展して広い表面積で動物の体表に密接に接触し、脱落率，駆除率ともに高まり、効果的に防除できることが立証された。

From the results of Tables 1 and 2, the animal ectoparasite control agent according to the present invention uses silicone as a spreading agent, spreads and comes into close contact with the body surface of the animal with a large surface area, and the dropout rate , It was proved that the extermination rate increased and it could be effectively controlled.

Claims (7)

  An animal ectoparasite control agent comprising an animal ectoparasite control substance and silicone.   The animal external parasitism according to claim 1, wherein the silicone is at least one selected from dimethyl silicone oil, highly polymerized dimethyl silicone oil, cyclic silicone oil, polyether-modified silicone oil, amino-modified silicone oil, and methylphenyl silicone oil. Insect control agent.   The animal ectoparasite control agent according to claim 1 or 2, wherein the content of silicone is 0.01 to 50.0% by weight in the control agent.   Animal ectoparasite control substance selected from pyrethroid compounds, organophosphorus compounds, carbamate compounds, chitin formation inhibitors, juvenile hormone-like substances, animal endoparasite control substances, pest repellent active substances and other insecticidal ingredients The ectoparasite control agent for animals according to any one of claims 1 to 3, which is as described above.   When the content of the ectoparasite control substance for animals is 0.001 to 10.0% by weight in the case of an insect growth control active compound, 0.01 to 80.0% by weight for other control substances excluding the insect growth control active compound The ectoparasite control agent for animals according to claim 1, which is%.   The animal ectoparasite control agent according to any one of claims 1 to 5, which is used for spot-on treatment.   The animal ectoparasite control agent according to any one of claims 1 to 5, which is for pour-on treatment.