WO2024069656A1

WO2024069656A1 - Insecticidal composition comprising n-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide

Info

Publication number: WO2024069656A1
Application number: PCT/IN2023/050898
Authority: WO
Inventors: Parikshit MUNDHRA; Jitendra Mohan
Original assignee: Willowood Chemicals Limited
Priority date: 2022-09-30
Filing date: 2023-09-30
Publication date: 2024-04-04

Abstract

The present invention provides insecticidal combination comprising first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide and a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine and Thiacloprid, formulation thereof and to a method of controlling undesired insects-pests in crops of useful plants.

Description

INSECTICIDAL COMPOSITION COMPRISING N-(CYANOMETHYL)-4- (TRIFLUOROMETHYL)-3-PYRIDINECARBOXAMIDE

FIELD OF THE INVENTION

The present invention relates to a insecticidal compositions comprising first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide and a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Deltamethrin, Diafenthiuron, Lambda-cyhalothrin, Pymetrozine and Thiacloprid, formulation thereof and to a method of controlling undesired insects-pests in crops of useful plants.

BACKGROUND OF THE INVENTION

In economically important crops, higher crop efficiency is achieved by controlling the invertebrate pests. Invertebrate pests cause damage to growing and stored agricultural crops and thereby result in significant reduction in the crop productivity. Therefore, the control of invertebrate pests is economically important for the enhanced crop productivity. Many products are available as solo or in combinations of two or more active ingredients. However, more economically efficient and ecologically safe insecticidal composition and methods are still being sought.

In order to reduce the risk from increased number of resistant pest strains, mixtures of different active compounds are nowadays employed for controlling harmful pests. By combining different active compounds having different mechanism of action, it is possible to effectively control pests of different groups over a relatively longer period of time and preventing development of resistance. However, this requires continuous development of an effective composition with different active compounds, so as to avoid selection to the particular mechanism of action.

Therefore, there exist a need in the art to develop an insecticidal compositions, which are stable, synergistic, broad spectrum, environmentally safe and effective in control of a wide spectrum of insect pests in crops. The insecticidal compositions must show a broader scope of activity to avoid or to prevent the development of resistant varieties of strains to the active ingredients or to the mixtures of known active ingredients used by farmer while minimising the doses of chemicals sprayed in the agriculture fields.

As a solution to the above mentioned problems, the inventors of the present invention surprisingly found that compositions comprising first insecticide A, N-(cyanomethyl)-4- (trifluoromethyl)-3-pyridinecarboxamide and a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine and Thiacloprid provides effective control of a wide spectrum of insect pests.

SUMMARY OF THE INVENTION

Accordingly, the present invention provides a compositions comprising first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide and a second insecticide B which is either selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is either selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine and Thiacloprid and agriculturally acceptable excipient(s).

In one aspect, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl) pyridine-3 -carboxamide in the range of 1-20% w/w; a second insecticide B which is selected from Abamectin in the range of 0.1-3%w/w or Chlorantraniliprole in the range of l-15%w/w or Spirotetramat in the range of l-13%w/w or Spiromesifen in the range of 3.6-28%w/w; a third insecticide C different from insecticide A and B which is selected from Bifenthrin in the range of 5 -27% w/w or Deltamethrin in the range of 0. l-5%w/w or Diafenthiuron in the range of 14-33%w/w or Lambda cyhalothrin in the range of l-8%w/w or Pymetrozine in the range of 5-28%w/w or Thiacloprid in the range of 5- 30%w/w; and agriculturally acceptable excipient(s).

In another aspect, the compositions of the present invention is selected from a group comprising: a) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Abamectin and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s); b) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Chlorantraniliprole and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s); c) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Spirotetramat and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s); d) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Spiromesifen and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s).

In one other aspect, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide preferably in the range of 4- 15%w/w, and a second insecticide B, Abamectin in the range of 0.4-1.2%w/w and a third insecticide C which is selected from Bifenthrin in the range of 16-24%w/w or Diafenthiuron in the range of 25-30%w/w or Deltamethrin in the range of 2-3%w/w or Lambda-cyhalothrin in the range of 3-5%w/w or Pymetrozine in the range of 13-25%w/w or Thiacloprid in the range of 13-27%w/w and agriculturally acceptable excipient(s).

In one other aspect, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide preferably in the range of 3.5- 15%w/w, and a second insecticide B, Chlorantraniliprole in the range of 3-12%w/w and a third insecticide C which is selected from Bifenthrin in the range of 8-12%w/w or Diafenthiuron in the range of 20-30%w/w or Deltamethrin in the range of 2-3%w/w or Lambda-cyhalothrin in the range of 4-5%w/w or Pymetrozine in the range of 8-15%w/w or Thiacloprid in the range of 12-18%w/w and agriculturally acceptable excipient(s). In one other aspect, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide preferably in the range of 3.3- 12.5%w/w, and a second insecticide B, Spirotetramat in the range of 3-10%w/w and a third insecticide C, which is selected from Bifenthrin in the range of 8-12%w/w or Diafenthiuron in the range of 17-25%w/w or Deltamethrin in the range of l-3%w/w or Lambda-cyhalothrin in the range of 3-4%w/w or Pymetrozine in the range of 8-15%w/w or Thiacloprid in the range of 8-18%w/w and agriculturally acceptable excipient(s).

In one other aspect, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide preferably in the range of 3.3- 12.5%w/w, and a second insecticide B, Spiromesifen in the range of 3.6-28%w/w and a third insecticide C which is selected from Bifenthrin in the range of 8-12%w/w or Diafenthiuron in the range of 17-25%w/w or Deltamethrin in the range of l-3%w/w or Lambda-cyhalothrin in the range of 3-4%w/w or Pymetrozine in the range of 8-15%w/w or Thiacloprid in the range of 8-18%w/w and agriculturally acceptable excipient(s).

In another aspect, the present invention provides a process of preparation of the compositions comprising first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide and a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine and Thiacloprid and agriculturally acceptable excipient(s).

In one another aspect, the compositions of the present invention is formulated as Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion oil-in-water (EW), Granules (GR), Micro-emulsion (ME), Oildispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WDG/WG), Wettable powder (WP), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), preferably SC, SE, WP and WDG. In one another aspect, the compositions of the present invention comprise one or more excipient(s) selected from the group comprising of dispersing agent(s), wetting agent(s), dispersing cum wetting agent(s), disintegrating agent(s), defoaming agent(s) / defoamer(s) / antifoaming agent(s) / antifoamer(s), biocide(s)/preservative(s), viscosity modifier(s)/ rheology modifier(s)/ thickener(s), anti-freeze agent(s), pH stabilizer(s), anti-caking agent(s), solvent(s), filler(s), diluent(s) or a combination thereof and other additives as will be required in a particular type of formulation.

In another aspect, the composition of the present invention comprises the dispersing agent is selected from the group comprising ethoxylated polyarylphenol phosphate amine salt, ethoxylated isodecyl alcohol, polymethyl methacrylate-polyethylene glycol graft copolymer, blend of acrylic graft copolymer and emulsifier, polymethyl methacrylate-polyethylene oxide graft copolymer, sodium salt of naphthalene sulfonate condensate, tristyrylphenol ethoxylate, anionic tristyrylphenol phosphate surfactant, non-ionic surfactant, polyalkoxylated butyl ether dispersant, sodium alkylnaphthalene sulfonate condensate, sodium lignosulphonate, sodium naphthalene sulphonate salt, sodium alkylnaphthalene sulfonate phenol condensate, sodium alkylnaphthalene sulfonate formaldehyde condensate, sodium polycarboxylate, modified styrene acrylic polymeric dispersant, modified styrene acrylic polymeric aqueous dispersant, proprietary blend of phosphate ester and sodium naphthalene sulphate formaldehyde condensate, lignosulfonic acid dispersant, kraft lignosulfonate with a low degree sulfonation, modified sodium lignosulphonate, naphthalene sulfonate formaldehyde condensate, mixture of salt of naphthalene sulphonic acid and phenol, alkyl naphthalene sulfonate sodium salt, modified naphthalene sulfonate formaldehyde condensate, highly sulfonated kraft lignin, naphthalene sulfonate phenol condensate, sodium isopropyl naphthalene sulfonate or a combination thereof and present in an amount from 0.1-20% w/w; the wetting agent is selected from the group comprising sodium alkyl naphthalene sulfonate blend, nonionic proprietary surfactant blend, sulphonated anionic wetter, copolymer condensate of ethylene and propylene oxide, ethoxylated isodecyl alcohol, sodium alkyl naphthalene sulfonate formaldehyde condensate, comb-type polymeric surfactant, polyalkylene oxide block copolymer, ethoxylated polyarylphenol phosphate amine salt, sodium isopropyl naphthalene sulfonate, dibutyl naphthalene sulfonic acid sodium salt, dialkyl naphthalene sulphonate, sodium dioctyl sulfo succinate or a combination thereof and present in an amount from 0.1-10% w/w; the dispersing cum wetting agent is selected from the group comprising proprietary blend of phosphate ester and sodium naphthalene sulfonate formaldehyde condensate, highly sulfonation and low molecular weight kraft lignin polymer, sodium salt of aromatic ring surfactant, ammonium salt of aromatic ring surfactant, sodium salt of naphthalene sulphonic acid condensation, proprietary blend of anionic surfactant, Jeemox 1269 (Jeevan chemicals private limited), proprietary blend of polymeric surfactant, sodium methyl oleoyl taurate, tristyrylphenol ethoxylate phosphate ester or a combination thereof and present in an amount from 2-10% w/w; the disintegrating agent is selected from ammonium sulphate, lactose or a combination thereof and present in an amount from 5-25% w/w; the antifoamer/defoamer is selected from the group comprising polydimethylsiloxane antifoam emulsion, silicon emulsion, poly siloxane emulsion or a combination thereof and present in an amount from 0.01 to 2% w/w; the biocide/preservative is selected from the group comprising 20% aqueous dipropyleneglycol solution of 1,2- benzisothiazolin-3-one, formaldehyde, isothiazolinone or a combination thereof and present in an amount from 0.01 to 1% w/w; the thickener is selected from the group comprising xanthan gum, welan gum, guar gum, polyvinyl alcohol, carboxymethylcellulose, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic polymer, starch derivative, polysaccharide, high purity silica, white carbon or a combination thereof and present in an amount from 0.1-5% w/w; the anti-freeze agent is selected from the group comprising glycerol, propylene glycol, diethylene glycol, monoethylene glycol or a combination thereof and present in an amount from 0.1 to 10% w/w; the pH stabilizer is citric acid and present in an amount from 0.1 to 3% w/w; the anti-caking agent is silica and present in an amount from 0.1 to 6% w/w; the solvent is selected from the group comprising naphtha, butan-l-ol, xylene, decanamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide, cyclohexanone, solvent C9, water or a combination thereof and present in an amount from 1 to 10% w/w; the filler is selected from the group comprising, silica, precipitated silica, sodium bicarbonate, china clay, lactose, bentonite clay, kaolin, diatomaceous earth or a combination thereof and present in an amount quantity sufficient; and the diluent is demineralised water and present in an amount quantity sufficient.

DETAILED DESCRIPTION OF THE INVENTION

The definitions provided herein for the terminologies used in the present disclosure are for illustrative purpose only and in no manner limit the scope of the present invention disclosed in the present disclosure.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by a person of ordinary skill in the art to which the invention pertains. Although other methods and materials similar, or equivalent, to those described herein can be used in the practice of the present invention, the preferred materials and methods are described herein.

It is to be noted that, as used in the specification and the appended claims, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.

As used herein, the terms "comprises", "comprising", "includes", "including", “has”, “having”, “contains”, “containing”, “characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process or a method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process or method.

The transitional phrase “consisting of’ excludes any element, step or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase “consisting of’ appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole.

As used herein, the terms “composition” or “compositions” or "formulation" or "formulations" can be used interchangeably, unless stated otherwise, is meant to encompass, and are not limited to, compositions or formulations containing the combination of N-(cyanomethyl)-4- (trifluoromethyl)-3-pyridinecarboxamide and a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine and Thiacloprid.

As used herein, the term “agriculturally acceptable excipient (s)” refers to inert substances and are auxiliary substances added to the processing or use of pesticide preparations and used to improve the physical and chemical properties of formulations. The auxiliaries themselves are essentially free of biological activity, but can affect the control effect.

The expression of various quantities in terms of “% w/w” or “%” means the percentage by weight, relative to the weight of the total solute on or composition unless otherwise specified.

The term “active ingredient” (a.i.) or “active agent” used herein refers to that component of the composition responsible for control of insects-pests in crops of useful plants.

As used herein, the term "effective amount" means the amount of the active substances in the compositions to achieve an observable effect on death, retardation, prevention, and removal, destruction, or otherwise diminishing the occurrence and activity of the target pests. An effective amount of the compositions will also vary according to the prevailing conditions such as desired insecticidal effect and duration, weather, target pests and species, target crops, locus, mode of application, and the like.

As used herein, the term “insecticide”, refers to any chemical substance used to destroy/kill, inhibit or otherwise adversely affect the insect pests.

As used herein, “N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide” is a pyridine carboxamide derivative compound and commonly known as “Flonicamid”. The term “Flonicamid” encompasses Flonicamid or its agrochemically acceptable salt(s), derivative(s) or any other modified form of Flonicamid. Flonicamid acts by inhibiting feeding and has systemic and translaminar activity. It is used to control aphids and some other sucking insects in fruit, cereals, potatoes, cotton, tea and vegetables.

As used herein, the term “Abamectin” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of Abamectin. Abamectin is a mixture of Avermectin Bia and Avermectin B lb wherein Avermectin B la is representing by CAS name 5-O-demethyl avermectin Ala and Avermectin B ib is representing by CAS name 5-O-demethyl-25-de (1- methylpropyl)-25-(l-methylethyl) avermectin Ala. Abamectin is known for its insecticide, acaricide (miticide) and a nematicide activities. It acts by stimulating the release of gamma aminobutyric acid, an inhibitory neurotransmitter, thus finally activating chloride channels. It is used for control of motile stage of mites, leaf miners, suckers, beetles etc. on ornamentals, cotton, citrus fruit, pome fruit, nut crops, vegetables, potatoes and other crops. As used herein, the term “Chlorantraniliprole” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of Chlorantraniliprole. Chlorantraniliprole having CAS name 3 -bromo-N-[4-chloro-2-methyl-6- [(methylamino) carbonyl] phenyl] -1 -(3- chloro-2-pyridinyl)-lH-pyrazole-5-carboxamide belongs to the class of diamide insecticide. It acts by activation of ryanodine receptors, leading to loss of internal calcium stores. It is used for control of wide range of chewing pests primarily Lepidoptera, Coleoptera, Dipetra and Isoptera in a broad range of crops including fruit, vegetables, vines, cotton, sugarcane, rice and grass.

As used herein, the term “Spirotetramat” encompasses its agrochemically acceptable salt(s), polymorph(s), derivative(s) or any other modified form of Spirotetramat. Spirotetramat having CAS name cis-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-l-azaspiro[4,5]dec-3-en-4-yl ethyl carbonate, belongs to the class of tetramic acid. It affects lipid biosynthesis through inhibition of acetyl CoA carboxylase, acting mainly after ingestion but also on contact, affecting eggs and larvae, with additional effects on adult fecundity. After penetrating the leaves, it is de- esterified, and transported within both the xylem and phloem. It also has translaminar activity. It is used for control of a range of sucking insects including whitefly, aphids, scales, mealybugs, psyllids and thrips species in vegetables, cotton, soybeans, pome and stone fruits, grapes, hopes, citrus, nut trees and bananas.

As used herein, the term “Spiromesifen” encompasses its agrochemically acceptable salt(s), polymorph(s), derivative(s) or any other modified form of Spiromesifen. Spiromesifen having CAS name 2-oxo-3-(2, 4, 6-trimethylphenyl)-l-oxasipro [4,4]non-3-en-4-yl 3, 3-dimethyl butanoate, belongs to the class of tetronic acid. It is a lipid biosynthesis inhibitor and nonsystemic. It is effective against whiteflies and against tetranychus spp., polyphagotarsonemus spp., and Paratrioza spp., in cotton, maize, potatoes, vegetables and ornamentals.

As used herein, the term “Bifenthrin” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of Bifenthrin. Bifenthrin having CAS name (2-methyl [l,r-biphenyl]-3-yl)methyl(lR.3R)-rel-3-[(lZ)-2-chloro-3,3,3-trifluoro-l-propen-l-yl]-2,2- dimethylcyclopropanecarboxylate, belongs to the class of pyrethroid. It acts on the nervous system of insects, disturbs the function of neurons by interaction with the sodium channel. It is effective against a broad range of foliar pests in cereals, citrus, cotton, fruit, grapes, ornamentals and vegetables. As used herein, the term “Diafenthiuron” encompasses its agrochemically acceptable salt(s), polymorph(s), derivative(s) or any other modified form of Diafenthiuron. Diafenthiuron having CAS name N- [2,6-bis( 1 -methylethyl)-4-phenoxyphenyl] -N’ -( 1 , 1 -dimethylethyl)thiourea, belongs to the class of thiourea insecticide/acaricide. Diafenthiuron is a potent in vivo inhibitor of mitochondrial respiration. It is an insecticide/acaricide which kills larvae, nymphs and adults by contact and/or stomach action and also shows some ovicidal action. It is effective against phytophagous mites and other sucking pests in cotton, various field and fruit crops, ornamental plants and vegetables.

As used herein, the term “Deltamethrin” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of Deltamethrin. Deltamethrin having CAS name (S)- cyano (3 -phenoxyphenyl) methyl (1R, 3R)-3-(2,2-dibromoethenyl)-2,2- dimethylcyclopropanecarboxylate, belongs to pyrethroid group of insecticides. It is a non- systemic insecticide with contact and stomach action. It prevents the sodium channels from functioning, so that no transmission of nerve impulses can take place. It is potent insecticide effective by contact and ingestion against a wide range of pests in cereals, citrus, cotton, grapes, maize, oilseed rape, soybeans, top fruits and vegetables.

As used herein, the term “Lambda-cyhalothrin” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of Lambda-cyhalothrin. Lambda-cyhalothrin having CAS name cyano (3 -phenoxyphenyl) methyl 3-(2-chloro-3,3,3-trifluoro-l-propen-l- yl)-2,2-dimethylcyclopropanecarboxylate, belongs to the class of pyrethroid insecticide. It is a non-systemic insecticide with contact and stomach action, and repellent properties. It acts on the nervous system of insects and disturbs the function of neurons by interaction with sodium channel. It controls aphids, beetles, thrips, Lepidoptera larvae, Coleoptera larvae and adults etc. in cereals, hops, ornamentals, potatoes, vegetables and other crops.

As used herein, the term “Pymetrozine” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of Pymetrozine. Pymetrozine having CAS name 4, 5- dihydro-6-methyl-4-[(E)-(3-pyridinylmethylene) amino]- 1, 2, 4-triazin-(2H)-one, belongs to the class of pyridine azomethine insecticide. Pymetrozine is selective against Homoptera, causing them to stop feeding. It provides control of juvenile and adult stages of aphids and whiteflies in vegetables, potatoes, ornamental, cotton, deciduous fruit, citrus, tobacco and hops and plant hoppers in rice. As used herein, the term “Thiacloprid” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of Thiacloprid. Thiacloprid having CAS name [N (Z)]-[3-[(6-chloro-3-pyridinyl) methyl] -2-thiazolidinylidene] cyanamide, belongs to the class of neonicotinoid insecticide. It acts as an agonist of the nicotinic acetylcholine receptor in the central nervous system, thus disturbing synaptic signal transmissions. It is used against sucking and biting insects in pome fruit, stone fruit, small berries, cotton, vegetables, sugar beet, potatoes, rice and ornamentals.

In an embodiment, the present invention provides a synergistic insecticidal compositions comprising first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide and a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Diaffenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine and Thiacloprid and agriculturally acceptable excipient(s).

In an embodiment, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl) pyridine-3-carboxamide in the range of l-20%w/w; a second insecticide B which is selected from Abamectin in the range of 0.1-3%w/w or Chlorantraniliprole in the range of l-15%w/w or Spirotetramat in the range of l-13%w/w or Spiromesifen in the range of 3.6-28%w/w; a third insecticide C different from insecticide A and B which is selected from Bifenthrin in the range of 5-27%w/w or Deltamethrin in the range of 0. l-5%w/w or Diafenthiuron in the range of 14-33%w/w or Lambda cyhalothrin in the range of l-8%w/w or Pymetrozine in the range of 5-28%w/w or Thiacloprid in the range of 5- 30%w/w and agriculturally acceptable excipient(s).

In an embodiment, the compositions of the present invention is selected from a group comprising first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3 -pyridinecarboxamide a second insecticide B, Abamectin and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s) or first insecticide A, N-(cyanomethyl)-4- (trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Chlorantraniliprole and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda- cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s) or first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Spirotetramat and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s) or first insecticide A, N-(cyanomethyl)-4- (trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Spiromesifen and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda- cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s).

In an embodiment, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide preferably in the range of 4- 15%w/w, and a second insecticide B, Abamectin in the range of 0.4-1.2%w/w and a third insecticide C which is selected from Bifenthrin in the range of 16-24%w/w or Diafenthiuron in the range of 25-30%w/w or Deltamethrin in the range of 2-3%w/w or Lambda-cyhalothrin in the range of 3-5%w/w or Pymetrozine in the range of 13-25%w/w or Thiacloprid in the range of 13-27%w/w and agriculturally acceptable excipient(s).

In an embodiment, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide preferably in the range of 3.5- 15%w/w, and a second insecticide B, Chlorantraniliprole in the range of 3-12%w/w and a third insecticide C which is selected from Bifenthrin in the range of 8-12%w/w or Diafenthiuron in the range of 20-30%w/w or Deltamethrin in the range of 2-3%w/w or Lambda-cyhalothrin in the range of 4-5%w/w or Pymetrozine in the range of 8-15%w/w or Thiacloprid in the range of 12-18%w/w and agriculturally acceptable excipient(s).

In an embodiment, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide preferably in the range of 3.3- 12.5%w/w, and a second insecticide B, Spirotetramat in the range of 3-10%w/w and a third insecticide C, which is selected from Bifenthrin in the range of 8-12%w/w or Diafenthiuron in the range of 17-25%w/w or Deltamethrin in the range of l-3%w/w or Lambda-cyhalothrin in the range of 3-4%w/w or Pymetrozine in the range of 8-15%w/w or Thiacloprid in the range of 8-18%w/w and agriculturally acceptable excipient(s).

In an embodiment, the compositions of the present invention comprises first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide preferably in the range of 3.3- 12.5%w/w, and a second insecticide B, Spiromesifen in the range of 3.6-28%w/w and a third insecticide C which is selected from Bifenthrin in the range of 8-12%w/w or Diafenthiuron in the range of 17-25%w/w or Deltamethrin in the range of l-3%w/w or Lambda-cyhalothrin in the range of 3-4%w/w or Pymetrozine in the range of 8-15%w/w or Thiacloprid in the range of 8-18%w/w and agriculturally acceptable excipient(s).

In another embodiment, the compositions of the present invention is formulated as Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion oil-in-water (EW), Granules (GR), Micro-emulsion (ME), Oildispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WDG/WG), Wettable powder (WP), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), preferably SC, SE, WP and WDG.

In one other embodiment, the compositions of the present invention comprise one or more excipient(s) selected from the group comprising of dispersing agent(s), wetting agent(s), dispersing cum wetting agent(s), disintegrating agent(s), defoaming agent(s) / defoamer(s) / antifoaming agent(s) / antifoamer(s), biocide(s)/preservative(s), viscosity modifier(s)/ rheology modifier(s)/ thickener(s), anti-freeze agent(s), pH stabilizer(s), anti-caking agent(s), solvent(s), filler(s), diluent(s) or a combination thereof and other additives as will be required in a particular type of formulation.

The compositions of present invention uses dispersing agents to prevent agglomeration of solid particles and keep them suspended in fluid. Non-limiting examples of dispersing agent that can be used in the present invention include, but not limited to ethoxylated polyarylphenol phosphate amine salt, ethoxylated isodecyl alcohol, polymethyl methacrylate-polyethylene glycol graft copolymer, blend of acrylic graft copolymer and emulsifier, polymethyl methacrylate-polyethylene oxide graft copolymer, sodium salt of naphthalene sulfonate condensate, tristyrylphenol ethoxylate, anionic tristyrylphenol phosphate surfactant, non-ionic surfactant, polyalkoxylated butyl ether dispersant, sodium alkylnaphthalene sulfonate condensate, sodium lignosulphonate, sodium naphthalene sulphonate salt, sodium alkylnaphthalene sulfonate phenol condensate, sodium alkylnaphthalene sulfonate formaldehyde condensate, sodium polycarboxylate, modified styrene acrylic polymeric dispersant, modified styrene acrylic polymeric aqueous dispersant, proprietary blend of phosphate ester and sodium naphthalene sulphate formaldehyde condensate, lignosulfonic acid dispersant, kraft ligno sulfonate with a low degree sulfonation, modified sodium lignosulphonate, naphthalene sulfonate formaldehyde condensate, mixture of salt of naphthalene sulphonic acid and phenol, alkyl naphthalene sulfonate sodium salt, modified naphthalene sulfonate formaldehyde condensate, highly sulfonated kraft lignin, naphthalene sulfonate phenol condensate, sodium isopropyl naphthalene sulfonate. One or more dispersing agents may be used in the compositions of the present invention. The dispersing agent is present in the range from 0.1-20% w/w.

The compositions of present invention uses wetting agent to facilitate the process of dispersion of the granules in the liquid. Non-limiting examples of wetting agents that can be used in the present invention include, but not limited to sodium alkyl naphthalene sulfonate blend, nonionic proprietary surfactant blend, sulphonated anionic wetter, copolymer condensate of ethylene and propylene oxide, ethoxylated isodecyl alcohol, sodium alkyl naphthalene sulfonate formaldehyde condensate, comb-type polymeric surfactant, polyalkylene oxide block copolymer, ethoxylated polyarylphenol phosphate amine salt, sodium isopropyl naphthalene sulfonate, dibutyl naphthalene sulfonic acid sodium salt, dialkyl naphthalene sulphonate, sodium dioctyl sulfosuccinate. One or more wetting agents may be used in the compositions of the present invention. The wetting agents is present in the range from 0.1-10% w/w.

The compositions of present invention also uses dispersing cum wetting agent. Non-limiting examples of dispersing cum wetting agent that can be used in the present invention include, but not limited to, proprietary blend of phosphate ester and sodium naphthalene sulfonate formaldehyde condensate, highly sulfonation and low molecular weight kraft lignin polymer, sodium salt of aromatic ring surfactant, ammonium salt of aromatic ring surfactant, sodium salt of naphthalene sulphonic acid condensation, proprietary blend of anionic surfactant, Jeemox 1269, proprietary blend of polymeric surfactant, sodium methyl oleoyl taurate, tristyrylphenol ethoxylate phosphate ester. One or more dispersing cum wetting agent may be used in the compositions of the present invention. Dispersing cum wetting agent is present in the range from 2-10% w/w. The compositions of present invention also uses disintegrating agent that can swell or disintegrate the composition. Non-limiting examples of disintegrating agent that can be used in the present invention include, but not limited to, ammonium sulphate, lactose. One or more disintegrating agent may be used in the compositions of the present invention. Disintegrating agent is present in the range from 5-25% w/w.

The composition of present invention also uses defoaming agent. The term “defoaming agent(s)” or “defoamer(s)” or “antifoaming agent(s)” “antifoamer(s)” refers to a chemical additive that reduces and hinders the formation of foam in liquid, semi- solid, or solid formulations. The terms defoaming agent and anti-foaming agent can be used interchangeably. Suitable defoamer used herein, but not limited to, polydimethylsiloxane antifoam emulsion, silicon emulsion, poly siloxane emulsion, organic fluorine compounds. One or more defoaming agent may be used in the compositions of the present invention. Defoaming agent is present in the range from 0.01 to 2% w/w.

The compositions of present invention uses biocide/preservatives to prevent the composition from spoilage due to bacteria, yeasts and fungi or deterioration due to undesirable chemical changes. Suitable biocide/preservative used herein, but not limited to 20% aqueous dipropylene glycol solution of 1,2- benzisothiazolin-3-one, formaldehyde, potassium sorbate, 4- hydroxybenzoic acid esters, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin- 3-one or a combination thereof and present in the range from 0.01-1% w/w.

The compositions of present invention uses thickener which are usually polymeric material, and at a low concentration increases the viscosity of an aqueous solution and helps to stabilize the composition. Suitable thickener used herein, but not limited to xanthan gum, welan gum, guar gum, polyvinyl alcohol, carboxymethylcellulose, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic polymer, starch derivative, polysaccharide, high purity silica, white carbon or a combination thereof and present in the range from 0.1-5% w/w.

The compositions of present invention uses anti-freeze agent which are used to prevent deleterious effects due to freezing and lyophilization (lyophilisation). Suitable anti-freeze agent used herein, but not limited to glycerol, propylene glycol, diethylene glycol, monoethylene glycol or a combination thereof and present in the range from 0.1 to 10% w/w. The compositions of present invention uses pH stabilizer also known as pH modifier and is used in any agrochemically acceptable composition for increasing or decreasing pH to have a storage stable formulation. The pH stabilizer is citric acid and present in the range from 0.1 to 3% w/w.

The compositions of present invention uses anti-caking agent. The anti-caking agent is silica and present in the range from 0.1 to 6% w/w.

The compositions of present invention uses solvent. Suitable solvent is selected from the group comprising naphtha, butan-l-ol, xylene, decanamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide, cyclohexanone, solvent C9, water or a combination thereof and present in range from 1 to 10% w/w.

The compositions of present invention uses filler. Suitable fillers that may be used in the compositions of the present invention include, but not limited to, silica, precipitated silica, sodium bicarbonate, china clay, lactose, bentonite clay, kaolin, diatomaceous earth. The filler may be used in an amount of quantity sufficient to make 100%w/w formulation.

The compositions of present invention uses diluents. Suitable diluents that may be used in the composition of the present invention is demineralised water and present in an amount quantity sufficient to make 100%w/w formulation.

The compositions of the present invention is found to be effective to control wide spectrum of insect pests from the orders of Lepidoptera, Isoptera, Acarina, Thysanoptera, particularly the compositions of present invention gave excellent control on aphid, jassids, whitefly, mites, thrips, shoots and fruits borer, stem borer, leaf folder and BPH. Further the composition of the present invention may be used to control variety of insect pests in cereals, paddy /rice, pulses, oilseeds, horticulture crops, fibre crops, vegetables and spice crops, particularly the compositions of present invention tested on Tea, Cotton, Rice, Brinjal and Chilli crops and gave better results compared to solo and binary compositions.

The present invention also provides a process of preparing a compositions comprising first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide and a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine and Thiacloprid and agriculturally acceptable excipient(s).

In an embodiment, the present invention provides a process for the preparation of a WP formulations which comprises: a) weighing and mixing of required active ingredients and other ingredients; b) milling in a suitable air jet mill; c) grinding the material to obtain desired particle size (D90- <10 micron) and d) mixing homogeneously in a blender to obtain the wettable powder formulation.

In an embodiment, the present invention provides a process for the preparation of a WDG formulations which comprises: a) preparing homogenous mixture of all ingredients; b) milling and grinding till desired particle size; c) preparing dough; d) extruding the granules and drying to obtain the water dispersible granules formulation.

In another embodiment, the present invention provides a process for the preparation of a SC formulations which comprises: a) diluting and solubilizing a biocide, defoamer, antifreeze agent and anti- settling agent in demineralised water in a mixing vessel and adding dispersing and wetting agent under stirring to get homogeneous mixture; b) adding active ingredients one by one under stirring and mixing till homogeneous slurry obtained; c)wet grinding at suitable temperature till desired particle size obtained, and d) adding previously prepared viscosity modifier solution and stirring to obtain SC formulation.

In another embodiment, the present invention provides a process for the preparation of a SE formulations. The process comprises: a) mixing of excipients and active ingredients to prepare to prepare a first composition in the form of SC, b) mixing at least one active ingredient with a solvent, an emulsifier (second dispersing agent) to obtain a second composition in the form of EC; e) mixing of first composition, second composition results in a composition of the present invention in SE form.

The compositions of the present invention can be applied by any one of the methods selected from atomization, spreading, dusting, spraying, diffusion, immersion, irrigation (chemigation), injection, mixing, sprinkling (water immersion), foaming, dressing, coating, blasting, fumigation, smoking, smog and painting. The rate of application amount of the prepared compositions varies depending on, for example, the blending ratio of active ingredients, meteorological condition, dosage form, application time, application method, application place, weed to be controlled, and a target crop, in ordinary cases.

The inventors of the present invention have surprisingly found that the compositions of the present invention showed enhances control over existing compositions. Moreover the composition of the present invention is more effective than their individual counterparts. This allows a substantial reduction in the application rates of each of these active ingredients, while maintaining good efficacy. The decrease in application rates reduces treatment cost to the farmer and also eases the burden on the environment both from manufacturing waste and crop protection chemical residues.

The insecticidal compositions of present invention provides a wide spectrum control of insectpests, delays the emergence of the resistant strains, minimizes the risk of development of resistance and achieves effective and economical control of undesired insect-pest.

The insecticidal compositions of the present invention provides a number of other advantages:

• Increased efficacy in comparison to the other formulations tested during the trial.

• Is synergistic hence denies the need of sequential application of solo insecticides to control different pest spectra thereby reducing the environmental load of insecticides.

• Uses lesser amounts of active ingredients hence considerable reduction in cost, which would benefit farmers.

• The compositions provided one shot solution to farmers to control broad spectrum of pests.

• Is storage stable.

• Is non-phytotoxic.

• Reduction in environmental load of insecticidal residues.

• Reduction in quantity of water required for spray of the product in agriculture fields.

• Reduction in generation of empty containers of product, thereby, reducing concerns of their disposal.

• Provides a broad range of product choice for effective pest management. Thus, from the foregoing description, it will be apparent to one of the person skilled in the art that many changes and modifications can be made thereto without departing from the scope of the invention as set forth in the description. Accordingly, it is not intended that the scope of the foregoing description be limited to the description set forth above, but rather that such description be construed as encompassing such features that reside in the present invention, including all the features and embodiments that would be treated as equivalents thereof by those skilled in the relevant art.

The embodiments of the present invention are more particularly described in the following examples that are intended as illustrations only, since numerous modifications and variations within the scope of the present invention will be apparent to those of skill in the art. Unless otherwise noted, all parts, percentages and ratios reported in the following examples are on a weight basis and all reagents used in the examples were obtained or are available from the chemical suppliers.

EXAMPLES

The insecticidal compositions of the present invention comprising first insecticide A, N- (cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide, and a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen and a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine and Thiacloprid, in the form of suspension concentrate (SC), suspoemulsion (SE), wettable powder (WP) and water dispersible granule (WDG) is provided in table 1-135. The unit of each component of the compositions are expressed in “% w/w” i.e. the percentage by weight, relative to the weight of the total solution or composition. All the compositions are prepared by following the processes as disclosed in description. All the prepared composition of the present invention has been tested for stability/shelf life at accelerated temperature.

Table 1: Examples 1 to 5: Composition of Flonicamid + Abamectin + Bifenthrin (SC)

Table 2: Quantities of ingredients charged to prepare the composition of Flonicamid 13% + Abamectinl% + Bifenthrin 24% (SC)

Table 3: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 4: Examples 6 to 10: Composition of Flonicamid + Abamectin + Bifenthrin (WP)

Table 5: Quantities of Ingredients charged to prepare the composition of Flonicamid 13% + Abamectin 1% + Bifenthrin 24% (WP)

Table 6: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 7: Examples 11 to 15: Composition of Flonicamid + Abamectin + Diafenthiuron (SC) | SN | Ingredients

Table 8: Quantities of Ingredients charged to prepare the composition of Flonicamid 6.5% + Abamectin 0.6% + Diafenthiuron 30% (SC)

Table 9: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 10: Examples 16 to 20: Composition of Flonicamid + Abamectin + Diafenthiuron (WP)

Table 11: Quantities of Ingredients charged to prepare the composition of Flonicamid 6.5% + Abamectin 0.6% + Diafenthiuron 30% (WP)

Table 12: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 13: Examples 21 to 25: Composition of Flonicamid + Abamectin + Deltamethrin (WP)

Table 14: Quantities of Ingredients charged to prepare the composition of Flonicamid 14% + Abamectin 1.2% + Deltamethrin 2% (WP)

Table 15: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 16: Examples 26 to 30: Composition of Flonicamid + Abamectin + Lambda cyhalothrin (SC)

Table 17: Quantities of Ingredients charged to prepare the composition of Flonicamid 15% + Abamectin 1.2% + Lambda cyhalothrin 5% (SC)

Table 18: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 19: Examples 31 to 35: Composition of Flonicamid + Abamectin + Lambda cyhalothrin (WP)

Table 20: Quantities of Ingredients charged to prepare the composition of Flonicamid 15% +

Abamectin 1.2% + Lambda cyhalothrin 5% (WP)

Table 21: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 22: Examples 36 to 40: Composition of Flonicamid + Abamectin + Pymetrozine (SC)

Table 23: Quantities of Ingredients charged to prepare the composition of Flonicamid 6.6% + Abamectin 0.8% + Pymetrozine 20% (SC)

Table 24: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 25: Examples 41 to 45: Composition of Flonicamid + Abamectin + Pymetrozine (WDG)

Table 26: Quantities of Ingredients charged to prepare the composition of Flonicamid 6.6% + Abamectin 0.8% + Pymetrozine 20% (WDG)

Table 27: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 28: Examples 46 to 50: Composition of Flonicamid + Abamectin + Pymetrozine (WP)

Table 29: Quantities of Ingredients charged to prepare the composition of Flonicamid 6.6% + Abamectin 0.8% + Pymetrozine 20% (WP)

Table 30: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 31: Examples 51 to 55: Composition of Flonicamid + Abamectin + Thiacloprid (SC)

Table 32: Quantities of Ingredients charged to prepare the composition of Flonicamid 9.1% + Abamectin 1% + Thiacloprid 17% (SC)

Table 33: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 34: Examples 56 to 60: Composition of Flonicamid + Abamectin + Thiacloprid (WP)

Table 35: Quantities of Ingredients charged to prepare the composition of Flonicamid 9.1% + Abamectin 1% + Thiacloprid 17% (WP)

Table 36: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 37: Examples 61 to 65: Composition of Flonicamid + Chlorantraniliprole + Bifenthrin (SC)

Table 38: Quantities of Ingredients charged to prepare the composition of Flonicamid 7.5% + Chlorantraniliprole 6% + Bifenthrin 10% (SC)

Table 39: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 40: Examples 66 to 70: Composition of Flonicamid + Chlorantraniliprole + Bifenthrin (WDG)

Table 41: Quantities of Ingredients charged to prepare the composition of Flonicamid 7.5% + Chlorantraniliprole 6% + Bifenthrin 10% (WDG)

Table 42: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 43: Examples 71 to 75: Composition of Flonicamid + Chlorantraniliprole + Diafenthiuron (SC)

Table 44: Quantities of Ingredients charged to prepare the composition of Flonicamid 6.5% + Chlorantraniliprole 5% + Diafenthiuron 30% (SC)

Table 45: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 46: Examples 76 to 80: Composition of Flonicamid + Chlorantraniliprole + Diafenthiuron (WDG)

Table 47: Quantities of Ingredients charged to prepare the composition of Flonicamid 6.5% + Chlorantraniliprole 5% + Diafenthiuron 30% (SC)

Table 48: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 49: Examples 81 to 85: Composition of Flonicamid + Chlorantraniliprole + Deltamethrin (SC)

Table 50: Quantities of Ingredients charged to prepare the composition of Flonicamid 15% + Chlorantraniliprole 12% + Deltamethrin 3% (SC)

Table 51: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 52: Examples 86 to 90: Composition of Flonicamid + Chlorantraniliprole + Deltamethrin (WDG)

Table 53: Quantities of Ingredients charged to prepare the composition of Flonicamid 15% + Chlorantraniliprole 12% + Deltamethrin 3% (WDG)

Table 54: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 55: Examples 91 to 95: Composition of Flonicamid + Chlorantraniliprole + Lambda cyhalothrin (SE)

Table 56: Quantities of Ingredients charged to prepare the composition of 7. Flonicamid 15% + Chlorantraniliprole 12% + Lambda cyhalothrin 5% (SE)

Table 57: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 58: Examples 96 to 100: Composition of Flonicamid + Chlorantraniliprole + Lambda cyhalothrin (WP)

Table 59: Quantities of Ingredients charged to prepare the composition of Flonicamid 15% + Chlorantraniliprole 12% + Lambda cyhalothrin 5% (WP)

Table 60: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 61: Examples 101 to 105: Composition of Flonicamid + Chlorantraniliprole + Py metrozine (SC)

Table 62: Quantities of Ingredients charged to prepare the composition of Flonicamid 4% + Chlorantraniliprole 4% + Py metrozine 12% (SC)

Table 63: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 64: Examples 106 to 110: Composition of Flonicamid + Chlorantraniliprole + Py metrozine (WDG)

Table 65: Quantities of Ingredients charged to prepare the composition of Flonicamid 4% + Chlorantraniliprole 4% + Pymetrozine 12% (WDG)

Table 66: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 67: Examples 111 to 115: Composition of Flonicamid + Chlorantraniliprole + Thiacloprid (SC)

Table 68: Quantities of Ingredients charged to prepare the composition of Flonicamid 4%+ Chlorantraniliprole 3% + Thiacloprid 10% (SC)

Table 69: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 70: Examples 116 to 120: Composition of Flonicamid + Chlorantraniliprole + Thiacloprid (WP)

Table 71: Quantities of Ingredients charged to prepare the composition of Flonicamid 4%+ Chlorantraniliprole 3% + Thiacloprid 10% (WP)

Table 72: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 73: Examples 121 to 125: Composition of Flonicamid + Spirotetramat + Bifenthrin (SC)

Table 74: Quantities of Ingredients charged to prepare the composition of Flonicamid 7.5%+ Spirotetramat 6% + Bifenthrin 10% (SC)

Table 75: Stability studies (Shelf life based on accelerated storage at 54 + 2°C)

Table 76: Examples 126 to 130: Composition of Flonicamid + Spirotetramat + Bifenthrin (WDG)

Table 77: Quantities of Ingredients charged to prepare the composition of Flonicamid 7.5%+ Spirotetramat 6% + Bifenthrin 10% (WDG)

Table 78: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 79: Examples 131 to 135: Composition of Flonicamid + Spirotetramat + Bifenthrin (WP)

Table 80: Quantities of Ingredients charged to prepare the composition of Flonicamid 7.5%+ Spirotetramat 6% + Bifenthrin 10% (WP)

Table 81: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 82: Examples 136 to 140: Composition of Flonicamid + Spirotetramat + Diafenthiuron (SC)

Table 83: Quantities of Ingredients charged to prepare the composition of Flonicamid 3.75%+ Spirotetramat 4.5% + Diafenthiuron 25% (SC)

Table 84: Stability studies (Shelf life based on accelerated storage at 54 + 2°C)

Table 85: Examples 141 to 145: Composition of Flonicamid + Spirotetramat + Diafenthiuron (WP)

Table 86: Quantities of Ingredients charged to prepare the composition of Flonicamid 3.75%+ Spirotetramat 4.5% + Diafenthiuron 25% (WP)

Table 87: Stability studies (Shelf life based on accelerated storage at 54 + 2°C)

Table 88: Examples 146 to 150: Composition of Flonicamid + Spirotetramat + Deltamethrin (SC)

Table 89: Quantities of Ingredients charged to prepare the composition of Flonicamid 12.5%+ Spirotetramat 8.3% + Deltamethrin 3% (SC)

Table 90: Stability studies (Shelf life based on accelerated storage at 54 + 2°C)

Table 91: Examples 151 to 155: Flonicamid + Spirotetramat + Deltamethrin (WP)

Table 92: Quantities of Ingredients charged to prepare the composition of Flonicamid 12.5%+ Spirotetramat 8.3% + Deltamethrin 3% (WP)

Table 93: Stability studies (Shelf life based on accelerated storage at 54 + 2°C)

Table 94: Examples 156 to 160: Composition of Flonicamid + Spirotetramat + Lambda cyhalothrin (SC)

Table 95: Quantities of Ingredients charged to prepare the composition of Flonicamid 12.5% + Spirotetramat 8.3% + Lambda cyhalothrin 4% (SC)

Table 96: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 97: Examples 161 to 165: Composition of Flonicamid + Spirotetramat + Lambda cyhalothrin (WP)

Table 98: Quantities of Ingredients charged to prepare the composition of Flonicamid 12.5%+ Spirotetramat 8.3% + Lambda cyhalothrin 4% (SC)

Table 99: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 100: Examples 166 to 170: Composition of Flonicamid 4% + Spirotetramat 6% + Pymetrozine 10% (WP)

Table 101: Quantities of Ingredients charged to prepare the composition of Flonicamid 4% + Spirotetramat 6% + Pymetrozine 10% (WP)

Table 102: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 103: Examples 171 to 175: Composition of Flonicamid + Spirotetramat + Thiacloprid (SC)

Table 104: Quantities of Ingredients charged to prepare the composition of Flonicamid 4%+ Spirotetramat 5% + Thiacloprid 10% (SC)

Table 105: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 106: Examples 176 to 180: Composition of Flonicamid + Spirotetramat + Thiacloprid (WP)

Table 107: Quantities of Ingredients charged to prepare the composition of Flonicamid 4% + Spirotetramat 5% + Thiacloprid 10% (WP)

Table 108: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 109: Examples 181 to 185: Composition of Flonicamid + Spiromesifen + Bifenthrin (SC)

Table 110: Quantities of Ingredients charged to prepare the composition of Flonicamid 5% + Spiromesifen 12% + Bifenthrin 12% (SC)

Table 111: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 112: Examples 186 to 190: Composition of Flonicamid + Spiromesifen + Diafenthiuron (SC)

Table 113: Quantities of Ingredients charged to prepare the composition of Flonicamid 6.2% + Spiromesifen 10% + Diafenthiuron 23% (SC)

Table 114: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 115: Examples 191 to 195: Composition of Flonicamid + Spiromesifen + Deltamethrin (SC)

Table 116: Quantities of Ingredients charged to prepare the composition of Flonicamid 12.5% + Spiromesifen 25% + Deltamethrin 3% (SC)

Table 117: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 118: Examples 196 to 200: Composition of Flonicamid + Spiromesifen + Deltamethrin (WP)

Table 119: Quantities of Ingredients charged to prepare the composition of Flonicamid 12.5% + Spiromesifen 25% + Deltamethrin 3% (WP)

Table 120: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 121: Examples 201 to 205: Composition of Flonicamid + Spiromesifen + Lambda cyhalothrin (WP)

Table 122: Quantities of Ingredients charged to prepare the composition of Flonicamid 12.5% + Spiromesifen 25% + Lambda cyhalothrin 4% (WP)

SN Ingredients

Qty gm

Table 123: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 124: Examples 206 to 210: Composition of Flonicamid + Spiromesifen + Pymetrozine (SC)

Table 125: Quantities of Ingredients charged to prepare the composition of Flonicamid 5% + Spiromesifen 12% + Pymetrozine 12% (SC)

Table 126: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 127: Examples 206 to 210: Composition of Flonicamid + Spiromesifen + Thiacloprid (SC)

Table 128: Quantities of Ingredients charged to prepare the composition of Flonicamid 8% +

Spiromesifen 15% + Thiacloprid 18% (SC)

Table 129: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 130: Examples 216 to 220: Composition of Flonicamid + Spiromesifen + Thiacloprid (WDG)

Table 131: Quantities of Ingredients charged to prepare the composition of Flonicamid 8% + Spiromesifen 15% + Thiacloprid 18% (WDG)

Table 132: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

Table 133: Examples 221 to 225: Composition of Flonicamid + Spiromesifen + Thiacloprid (WP)

Table 134: Quantities of Ingredients charged to prepare the composition of Flonicamid 8% + Spiromesifen 15% + Thiacloprid 18% (WP)

Table 135: Stability studies (Shelf life based on accelerated storage at 54 ± 2°C)

As evident from the foregoing tables (1-135) that all the desired compositions have been prepared successfully and has been tested for stability/shelf life at accelerated temperature. After 14 days of storage at 54.0 ± 2 °C, there were no significant changes in active ingredient content, suspensibility, wettability, dispersibility, pH and has passes the sieve test. Therefore, it is concluded that composition of present invention has good stability and shelf life.

BIO-EFFICACY OF THE INSECTICIDAL COMPOSITIONS OF THE PRESENT INVENTION

Experimental trial was conducted to evaluate the insecticidal compositions of the present invention in India against major insects on Tea, Paddy/Rice, Cotton, Brinjal and Chilli Crop with ternary composition of present invention and comparative solo and binary compositions as per the details provided in Table 136-178. The abbreviations used in table 136-178 are as follows:

TN: Treatment Number g.a.i: gram active ingredients ha: hectare

DAA: Days after Insecticide application

O=Observed % insect reduction (%) Calculated using Abbott Formula;

E=Expected % insect reduction Calculated using Colby Formula;

CR=Colby ratio

UTC: Untreated control BPH: Brown planthopper

Experimental design and method for Tea Crop

The present field experiment was conducted at Malwajar of Siliguri (North East region) during the season Summer-2022 with thirteen treatments replicated thrice in randomized block design. 8 years old Tea orchard of variety (TV-26) planted at spacing 60 X 60 cm in sandy loam soil with a plot size of 5m X 5m was selected for present experiment. The crop was maintained well by adapting standard agronomic practices. The treatments were imposed when aphid and mites population attained economic threshold level. Total two round of sprays were given, 1^st at 0 days and 2^nd at after 10 days. The populations of sucking pest viz., aphids were recorded on leaves at 5 Cm Tea shoot and mites were recorded from top, middle and bottom leaves of ten randomly tagged plants per plot at a day (0 day) before first spray and 7 and 14 days after application (DAA). The applications were carried out by using the hand operated aspire Knapsack sprayer pump fitted with hollow cone nozzle. The required quantity of water volume was used @ 500 litre per hectare. The % reduction in target insect population over control was calculated by using Abbott's formula: Reference: Abbot, W.S. (1925). A method of computing the effectiveness of an insecticide. J. Econ. Entomol.; 18 : 265-267. n in T after treatment

Corrected % Insect Reduction= 1- X 100

n in Co after treatment

Where, n = no. of insects; T = Treated; Co = Control

Experimental design and method for Cotton Crop

The present field experiment was conducted in Amravati district of Maharashtra state during the season Kharif-2022 with thirteen treatments replicated thrice in randomized block design. The Cotton hybrid Surpass Super was sown in a plot size of 5.4m X 5.4m for each replication with a spacing of 90cm X 60cm in black Cotton soil. The crop was maintained well by adapting standard agronomic practices. The treatments were imposed when aphid, jassids, thrips, whitefly and mites population attained economic threshold level. Total two round of sprays were given, 1^st at 0 days and 2^nd at after 10 days. The populations of sucking pest viz., aphid, jassids, thrips, whitefly and mites were recorded from top, middle and bottom leaves of five randomly tagged plants per plot at a day (0 day) before first spray and 7 and 14 days after application (DAA). The applications were carried out by using the hand operated aspire Knapsack sprayer pump fitted with hollow cone nozzle. The required quantity of water volume was used @ 500 litre per hectare. The % reduction in target insect population over control was calculated by using Abbott's formula as given above.

Experimental design and method for Paddy/Rice Crop

The present field experiment was conducted in Rajahmundry of East Godavari district of Andhra Pradesh state during the season Kharif-2022 with thirteen treatments replicated thrice in randomized block design. The Paddy/Rice variety MTU- 1061 was selected for the experiment. The crop was transplanted in a plot size of 5m X 5m for each replication with a spacing of 20cm X 15cm in sandy loam soil. The crop was maintained well by adapting standard agronomic practices. Total two round of sprays were given, 1^st at 0 days and 2^nd at after 10 days. The applications were carried out by using the hand operated aspire Knapsack sprayer pump fitted with hollow cone nozzle. The required quantity of water volume was used @ 500 litre per hectare. The treatments were imposed when paddy stem borer and leaf folder pest attained economic threshold level. The observations on stem borer damage were recorded on no. of dead hearts (DH) at a day (0 day) before first spray and 7 and 14 days after application (DAA) on 10 randomly selected hills per plot while the total number of damaged leaves per 10 randomly selected hills in each treatment, under each replication was recorded at a day (0 day) before first spray and 7 and 14 days after application (DAA) in order to assess leaf folder damage. The % reduction in target insect population over control was calculated by using Abbott's formula as given above.

Experimental design and method for Brinjal Crop

The present field experiment was conducted at Nandgaon of Amravati district of Maharashtra state during the season Kharif-2022 with thirteen treatments replicated thrice in randomized block design. The popular and widely cultivated variety Sanjay selected for this experiments was sown in a plot size of 5m X 5m for each replication with a spacing of 40cm X 60cm in black Cotton soil. The crop was maintained well by adapting standard agronomic practices. The treatments were imposed when aphid, jassids, whitefly and mites population and Shoot and fruit borer attained economic threshold level. Total two round of sprays were given, 1^st at 0 days and 2^nd at after 10 days. The observations on counts of sucking pest viz., aphid, jassid whitefly and mites were recorded on five randomly tagged plants per treatment plot. On each plant, three leaves (one each from bottom, middle and top portion of the plant) were observed to note the pest count. First count was taken at a day (0 day) before first spray and post treatment counts were made at 7 and 14 days after application (DAA) whereas crop damage caused by Brinjal shoot and fruit borer (BSFB) was measured on the basis of damaged fruits. In order to assess the % fruit damage, the damage fruits on five randomly selected tagged plants were counted as against total available fruits on the observed plants. Fruit damage was recorded after first and second application. The applications were carried out by using the hand operated aspire Knapsack sprayer pump fitted with hollow cone nozzle. The required quantity of water volume was used @ 500 litre per hectare. The % reduction in target insect population over control was calculated by using Abbott's formula as given above. The % fruit damage by Brinjal shoot and fruit borer (BSFB) was calculated by using following formula:

No. of damaged fruits

Percent fruit damage = - x 100

Total number of fruits

Experimental design and method for Chilli Crop

The present field experiment was conducted at Baptala of Guntur district of Andhra Pradesh state during the season Kharif-2022 with thirteen treatments replicated thrice in randomized block design. The popular and widely cultivated Guntur Chilli variety S-4 selected for this experiments was sown in a plot size of 5m X 5m for each replication with a spacing of 60cm X 45cm in sandy loam soil. The crop was maintained well by adapting standard agronomic practices. The treatments were imposed when thrips, jassids, whitefly and mites population and fruit borer attained economic threshold level. Total two round of sprays were given, 1^st at 0 days and 2^nd at after 10 days. The observations on counts of sucking pest viz., thrips, jassid, whitefly and mites were recorded on five randomly tagged plants per treatment plot. On each plant, five leaves (two each from bottom and middle and one from top portion of the plant) were observed to note the pest count. First count was taken at a day (0 day) before first spray and post treatment counts were made at 7 and 14 days after application (DAA) whereas crop damage caused by Chilli fruit borer was measured on the basis of damaged fruits. In order to assess the % fruit damage, the damage fruits on five randomly selected tagged plants were counted as against total available fruits on the observed plants. Fruit damage was recorded after first and second application. The applications were carried out by using the hand operated aspire Knapsack sprayer pump fitted with hollow cone nozzle. The required quantity of water volume was used @ 500 litre per hectare. The % reduction in target insect population over control was calculated by using Abbott's formula as given above. The % fruit damage by Chilli fruit borer was calculated by using formula as given above. Evaluation of synergistic effect

A synergistic effect exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components. Synergism was calculated by using Colby’s method, Weeds, vol. 15 No. l(Jan 1967), pp. 20-2.

The synergistic action expected for a given combination of three active components can be calculated as follows:

(XY+YZ+XZ) > XYZ

E=(X+Y+Z)

100 ⁺ 10000

Where:

E represents expected percentage of control for the combination of the three active ingredients at defined doses (for example equal to x, y and z respectively),

X is the percentage of control observed by the compound (I) at a defined dose (equal to x),

Y is the percentage of control observed by the compound (II) at a defined dose (equal to y),

Z is the percentage of control observed by the compound (III) at a defined dose (equal to z).

If observed control of the combination > Expected control, the combination is synergistic (Colby ratio > 1)

If observed control of the combination < Expected control, the combination is antagonistic (Colby ratio < 1)

If observed control of the combination = Expected control, the combination is additive (Colby ratio =1)

Phytotoxicity Observations: Insecticidal combinations of the present invention were found to be non-phytotoxic on tested crops.

Table 136: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Bifenthrin on Tea Crop against Aphids and Mites.

Table 137: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Deltamethrin on Tea Crop against Aphids and Mites.

Table 138: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Diafenthiuron on Cotton Crop against Aphids, Jassids and Thrips.

Table 139: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Diafenthiuron on Cotton Crop against Whitefly and Mites

Table 140: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Lambda cyhalothrin on Brinjal Crop against Shoot & fruit borer, Aphids and Jassids.

Table 141: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Lambda cyhalothrin on Brinjal Crop against Whitefly and Mites.

Table 142: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Pymetrozine on Cotton Crop against Aphids, Jassids and Thrips.

Table 143: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Pymetrozine on Cotton Crop against Whitefly and Mites.

Table 144: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Thiacloprid on Chilli Crop against Fruit & Shoot borer, Thrips and Whitefly.

Table 145: Efficacy of Insecticidal Composition Flonicamid + Abamectin + Thiacloprid on Chilli Crop against Jassids and Mites.

Table 146: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Bifenthrin on Rice Crop against Stem borer and Leaf folder.

Table 147: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Deltamethrin on Rice Crop against Stem borer and Leaf folder.

Table 148: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Diafenthiuron on Cotton Crop against Aphid and Jassids.

Table 149: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Diafenthiuron on Cotton Crop against Thrips and Whitefly.

Table 150: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Lambda cyhalothrin on Brinjal Crop against Shoot & fruit borer and Aphid.

Table 151: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Lambda cyhalothrin on Brinjal Crop against Jassids.

Table 152: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Pymetrozine on Rice Crop against Stem borer and Leaf folder.

Table 153: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Pymetrozine on Rice Crop against BPH.

Table 154: Efficacy of Insecticidal Composition Flonicamid + Chlorantraniliprole + Thiacloprid on Rice Crop against Stem borer and Leaf folder.

Table 155: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Bifenthrin on Cotton Crop against Aphids, Jassids and Thrips.

Table 156: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Bifenthrin on Cotton Crop against Whitefly and Mites.

Table 157: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Deltamethrin on Chilli Crop against Fruit & Shoot borer, Thrips and Whitefly.

Table 158: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Deltamethrin on Chilli Crop against Jassids and Mites.

Table 159: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Diafenthiuron on Cotton Crop against Aphid, Jassids and Thrips.

Table 160: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Diafenthiuron on Cotton Crop against Whitefly and Mites.

Table 161: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Lambda cyhalothrin on Brinjal Crop against Fruit & Shoot borer, Aphid and Jassids.

Table 162: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Lambda cyhalothrin on Brinjal Crop against Whitefly and Mites.

Table 163: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Pymetrozine on Cotton Crop against Aphid, Jassids and Thrips.

Table 164: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Pymetrozine on Cotton Crop against Whitefly and Mites.

Table 165: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Thiacloprid on Chilli Crop against Fruit & Shoot borer, Thrips and Whitefly.

Table 166: Efficacy of Insecticidal Composition Flonicamid + Spirotetramat + Thiacloprid on Chilli Crop against Jassids and Mites.

Table 167: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Bifenthrin on Chilli Crop against Thrips and Whitefly.

Table 168: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Bifenthrin on Chilli Crop against Jassids and Mites.

Table 169: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Deltamethrin on Chilli Crop against Fruit & Shoot borer, Thrips and Whitefly.

Table 170: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Deltamethrin on Chilli Crop against Jassids and Mites.

Table 171: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Diafenthiuron on Chilli Crop against Thrips and Whitefly.

Table 172: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Diafenthiuron on Chilli Crop against Jassids and Mites.

Table 173: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Lambda cyhalothrin on Brinjal Crop against Shoot & fruit borer, Aphid and Jassids.

Table 174: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Lambda cyhalothrin on Brinjal Crop against Whitefly and Mites.

Table 175: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Pymetrozine on Cotton Crop against Aphid and Jassids.

Table 176: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Pymetrozine on Cotton Crop against Thrips and Whitefly.

Table 177: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Thiacloprid on Chilli Crop against Fruit & Shoot borer, Thrips and Whitefly.

Table 178: Efficacy of Insecticidal Composition Flonicamid + Spiromesifen + Thiacloprid on Chilli Crop against Jassids and Mites.

It is evident from the above tables 136-178 that the ternary insecticidal composition of the present invention gave good control on crops against tested insects wherein all the prepared ternary composition found synergistic as compared to the reference products (solo or binary composition). It has also been found that use of ternary compositions of present invention not only gave better efficiency by using low a.i., content compared to binary and solo composition but also broaden the spectrum of compositions as the solo and binary compositions are not providing sufficient insect control in given duration.

It has also been found that the ternary compositions of present invention provides a readymade solution in one go to control the major insects on crops which are notorious and crops damaging as the timings of insects attack on crops are very ascertain and till the time farmers controls one pest, another pest attacks hence an insecticide having broad spectrum control always recommended. It has been observed that composition of Flonicamid and Bifenthrin is not effective against Mites whereas composition of Flonicamid +Abamectin+ Bifenthrin have better control on both Mites and Aphid. Similarly, composition of Flonicamid + Deltamethrin and Abamectin + Deltamethrin are not able to control both mites and Aphids in one go but ternary composition Flonicamid + Abamectin + Deltamethrin is able to control Aphids and Mites effectively at very low dose hence providing dual advantage to farmers first controlling all notorious insects by a single application and secondly low a.i. content thereby reducing overall cost. As can be seen from above tables that composition of Abamectin + Lambda- cyhalothrin is not effective to Aphids and Jassids whereas ternary composition Flonicamid + Abamectin + Lambda cyhalothrin is not only effective against Aphids and Jassids but at the same time controls Shoot & fruit borer, Whitefly and Mites also. It has also been seen that composition of Abamectin + Pymetrozine found non effective against Aphids, Jassids and Thrips whereas ternary composition Flonicamid + Abamectin + Pymetrozine proved synergistic and effectively controlled Aphids, Jassids, Thrips, Whitefly and Mites. Similar type of observation noticed for composition Flonicamid + Abamectin which is non effective against Fruit & Shoot borer whereas ternary composition Flonicamid + Abamectin + Thiacloprid found synergistic and very effectively controlled all the tested pests- Fruit & Shoot borer, Thrips, Whitefly, Jassids and Mites. Same type of observation is noticed for composition of Chlorantraniliprole + Bifenthrin which gave only 40-50 % control on stem borer and leaf folder, but when it combined with Flonicamid then the prepared ternary composition shows over 90 % control that too at low dose. Similarly composition of Flonicamid + Chlorantraniliprole is very poor to control whitefly but when it combine with Diafenthiuron then the ternary composition became synergistic and able to control broad range of pests. Similarly, composition of Chlorantraniliprole + Lambda-cyhalothrin is ineffective to control Aphids but when it combine with Flonicamid then the ternary composition not only controls Aphids but became synergistic and able to control broad range of pests. For controlling stem borer and leaf folder generally Chlorantraniliprole is recommended which gave only around 30% control to stem borer and leaf folder, when it combined with Pymetrozine then only around 5% enhancement in activity is observed, surprisingly ternary composition Flonicamid + Chlorantraniliprole + Pymetrozine gave more than 90% control of pests. Same type of observation is noticed for compositions of Spirotetramat which is found effective mainly against whitefly and mites but cannot control Fruit & Shoot borer occurrence of which cannot be overruled at the same time, but when it combine with Flonicamid and Deltamethrin then the prepared ternary composition not only able to control Fruit & Shoot borer, Thrips, Whitefly Jassids and Mites but also became synergistic. Similarly, the composition of Flonicamid + Spirotetramat found to be very poor against Fruit & Shoot borer and Aphid but the ternary composition of Flonicamid + Spirotetramat + Lambda cyhalothrin gave excellent control of pest such as Fruit & Shoot borer, Aphid, Jassids Whitefly and Mites. Further Flonicamid solo, Spiromesifen solo, Diafenthiuron solo were very poor to controls thrips on chilli crop but the ternary composition of Flonicamid + Spiromesifen + Diafenthiuron gave more than 90 % control of Thrips and Whitefly. In the same way binary composition Flonicamid + Spiromesifen or Flonicamid + Pymetrozine gave only 20-30% control of Thrips whereas ternary composition Flonicamid + Spiromesifen + Pymetrozine gave 90% control on Thrips hence proved synergistic. For the sake of brevity the interpretation of all the tables 136-178 is not explained here as the results in tables are self- speaking.

From the foregoing it will be observed that numerous modifications and variations can be effectuated without departing from the true spirit and scope of the novel concepts of the present invention. It is to be understood that no limitations with respect to the specific embodiments illustrated is intended or should be inferred. It should be understood that all such modifications and improvements have been deleted herein for the sake of conciseness and readability but are properly within the scope of the following claims.

Claims

CLAIMS:

1. An insecticidal compositions comprising: a) a first insecticide A which is N-(cyanomethyl)-4-(trifluoromethyl)pyridine-3- carboxamide; b) a second insecticide B which is selected from Abamectin, Chlorantraniliprole, Spirotetramat, Spiromesifen; c) a third insecticide C different from insecticide A and B which is selected from Bifenthrin, Deltamethrin, Diafenthiuron, Lambda cyhalothrin, Pymetrozine, Thiacloprid; and d) Agriculturally acceptable excipient(s).

2. The insecticidal compositions as claimed in claim 1, comprising: a) a first insecticide A which is N-(cyanomethyl)-4-(trifluoromethyl)pyridine-3- carboxamide in the range of 1-20% w/w; b) a second insecticide B which is selected from Abamectin in the range of 0.1-3%w/w, Chlorantraniliprole in the range of l-15%w/w, Spirotetramatin the range of l-13%w/w, Spiromesifen in the range of 3.6-28%w/w; c) a third insecticide C different from insecticide A and B which is selected from Bifenthrin in the range of 5-27%w/w, Deltamethrin in the range of 0.1-5%w/w, Diafenthiuron in the range of 14-33%w/w, Lambda cyhalothrin in the range of 1- 8%w/w, Pymetrozine in the range of 5-28%w/w, Thiacloprid in the range of 5- 30%w/w; and d) Agriculturally acceptable excipient(s).

3. The insecticidal compositions as claimed in claim 1, wherein the composition is selected from a group comprising: a) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Abamectin and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s); b) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Chlorantraniliprole and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s); c) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Spirotetramat and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s) and d) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide a second insecticide B, Spiromesifen and a third insecticide C which is selected from Bifenthrin, Diafenthiuron, Deltamethrin, Lambda-cyhalothrin, Pymetrozine, Thiacloprid and agriculturally acceptable excipient(s).

4. The insecticidal compositions as claimed in claim 1, wherein the composition is selected from a group comprising: a) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide in an amount 4-15%w/w, and a second insecticide B, Abamectin in an amount 0.4-1.2%w/w and a third insecticide C which is selected from Bifenthrin in an amount 16-24%w/w, Diafenthiuron in an amount 25-30%w/w, Deltamethrin in an amount 2-3%w/w, Lambda-cyhalothrin in an amount 3-5%w/w, Pymetrozine in an amount 13-25%w/w, Thiacloprid in an amount 13-27%w/w and agriculturally acceptable excipient(s); b) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide in an amount 3.5-15%w/w, and a second insecticide B, Chlorantraniliprole in an amount 3- 12%w/w and a third insecticide C which is selected from Bifenthrin in an amount 8- 12%w/w, Diafenthiuron in an amount 20-30%w/w, Deltamethrin in an amount 2- 3%w/w, Lambda-cyhalothrin in an amount 4-5%w/w, Pymetrozine in an amount 8- 15%w/w, Thiacloprid in an amount 12-18%w/w and agriculturally acceptable excipient(s); c) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide in an amount 3.3-12.5%w/w, and a second insecticide B, Spirotetramat in an amount 3- 10%w/w and a third insecticide C, which is selected from Bifenthrin in an amount 8- 12%w/w, Diafenthiuron in an amount 17-25%w/w, Deltamethrin in an amount 1- 3%w/w, Lambda-cyhalothrin in an amount 3-4%w/w, Pymetrozine in an amount 8- 15%w/w, Thiacloprid in an amount 8-18%w/w and agriculturally acceptable excipient(s); and d) first insecticide A, N-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide in an amount 3.3-12.5%w/w, and a second insecticide B, Spiromesifen in an amount 3.6- 28%w/w and a third insecticide C which is selected from Bifenthrin in an amount 8- 12%w/w, Diafenthiuron in an amount 17-25%w/w, Deltamethrin in an amount 1- 3%w/w, Lambda-cyhalothrin in an amount 3-4%w/w, Pymetrozine in an amount 8- 15%w/w, Thiacloprid in an amount 8-18%w/w and agriculturally acceptable excipient(s).

5. The insecticidal compositions as claimed in claim 1, wherein the compositions is formulated as Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion oil-in-water (EW), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WDG/WG), Wettable powder (WP), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), preferably SC, SE, WP and WDG.

6. The insecticidal compositions as claimed in claim 1, wherein the excipients is selected from the group comprising of dispersing agent, wetting agent, dispersing cum wetting agent, disintegrating agent, defoaming agent/ defoamer/ antifoaming agent/ antifoamer, biocide/preservative, viscosity modifier/ rheology modifier/ thickener, anti-freeze agent, pH stabilizer, anti-caking agent, solvent, filler and diluent.

7. The insecticidal compositions as claimed in claim 6, wherein; a. the dispersing agent is selected from the group comprising ethoxylated polyarylphenol phosphate amine salt, ethoxylated isodecyl alcohol, polymethyl methacrylatepolyethylene glycol graft copolymer, blend of acrylic graft copolymer and emulsifier, poly methyl methacrylate-poly ethylene oxide graft copolymer, sodium salt of naphthalene sulfonate condensate, tristyrylphenol ethoxylate, anionic tristyrylphenol phosphate surfactant, non-ionic surfactant, polyalkoxylated butyl ether dispersant, sodium alkylnaphthalene sulfonate condensate, sodium lignosulphonate, sodium naphthalene sulphonate salt, sodium alkylnaphthalene sulfonate phenol condensate, sodium alkylnaphthalene sulfonate formaldehyde condensate, sodium polycarboxylate, modified styrene acrylic polymeric dispersant, modified styrene acrylic polymeric aqueous dispersant, proprietary blend of phosphate ester and sodium naphthalene sulphate formaldehyde condensate, lignosulfonic acid dispersant, kraft ligno sulfonate with a low degree sulfonation, modified sodium lignosulphonate, naphthalene sulfonate formaldehyde condensate, mixture of salt of naphthalene sulphonic acid and phenol, alkyl naphthalene sulfonate sodium salt, modified naphthalene sulfonate formaldehyde condensate, highly sulfonated kraft lignin, naphthalene sulfonate phenol condensate, sodium isopropyl naphthalene sulfonate or a combination thereof and present in an amount from 0.1-20% w/w; b. the wetting agent is selected from the group comprising sodium alkyl naphthalene sulfonate blend, nonionic proprietary surfactant blend, sulphonated anionic wetter, copolymer condensate of ethylene and propylene oxide, ethoxylated isodecyl alcohol, sodium alkyl naphthalene sulfonate formaldehyde condensate, comb-type polymeric surfactant, polyalkylene oxide block copolymer, ethoxylated polyarylphenol phosphate amine salt, sodium isopropyl naphthalene sulfonate, dibutyl naphthalene sulfonic acid sodium salt, dialkyl naphthalene sulphonate, sodium dioctyl sulfosuccinate or a combination thereof and present in an amount from 0.1-10% w/w; c. the dispersing cum wetting agent is selected from the group comprising proprietary blend of phosphate ester and sodium naphthalene sulfonate formaldehyde condensate, highly sulfonation and low molecular weight kraft lignin polymer, sodium salt of aromatic ring surfactant, ammonium salt of aromatic ring surfactant, sodium salt of naphthalene sulphonic acid condensation, proprietary blend of anionic surfactant, Jeemox 1269, proprietary blend of polymeric surfactant, sodium methyl oleoyl taurate, tristyrylphenol ethoxylate phosphate ester or a combination thereof and present in an amount from 2- 10% w/w; d. the disintegrating agent is selected from ammonium sulphate, lactose or a combination thereof and present in an amount from 5-25% w/w; e. the antifoamer/defoamer is selected from the group comprising polydimethylsiloxane antifoam emulsion, silicon emulsion, polysiloxane emulsion or a combination thereof and present in an amount from 0.01 to 2% w/w; f. the biocide/preservative is selected from the group comprising 20% aqueous dipropyleneglycol solution of 1,2- benzisothiazolin-3-one, formaldehyde, isothiazolinone or a combination thereof and present in an amount from 0.01 to 1% w/w; g. the thickener is selected from the group comprising xanthan gum, welan gum, guar gum, polyvinyl alcohol, carboxymethylcellulose, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic polymer, starch derivative, polysaccharide, high purity silica, white carbon or a combination thereof and present in an amount from 0.1-5% w/w; h. the anti-freeze agent is selected from the group comprising glycerol, propylene glycol, diethylene glycol, monoethylene glycol or a combination thereof and present in an amount from 0.1 to 10% w/w; i. the pH stabilizer is citric acid and present in an amount from 0.1 to 3% w/w; j. the anti-caking agent is silica and present in an amount from 0.1 to 6% w/w; k. the solvent is selected from the group comprising naphtha, butan-l-ol, xylene, decanamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide, cyclohexanone, solvent C9, water or a combination thereof and present in an amount from 1 to 10% w/w; l. the filler is selected from the group comprising, silica, precipitated silica, sodium bicarbonate, china clay, lactose, bentonite clay, kaolin, diatomaceous earth or a combination thereof and present in an amount quantity sufficient; and m. the diluent is demineralised water and present in an amount quantity sufficient.