CN108967434B - A kind of highly efficiency compositional mosquito repellent liquid - Google Patents
A kind of highly efficiency compositional mosquito repellent liquid Download PDFInfo
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- CN108967434B CN108967434B CN201811241172.2A CN201811241172A CN108967434B CN 108967434 B CN108967434 B CN 108967434B CN 201811241172 A CN201811241172 A CN 201811241172A CN 108967434 B CN108967434 B CN 108967434B
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- icaridin
- peppermint
- glycol
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/06—Oxygen or sulfur directly attached to a cycloaliphatic ring system
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Abstract
The invention discloses a kind of highly efficiency compositional mosquito repellent liquid, effective component includes the pure and mild Icaridin of peppermint two.It is raw material that wherein peppermint glycol, which is by the eucalyptus quintessence oil naturally extracted, is obtained under the catalytic action of acid.A kind of highly efficiency compositional mosquito repellent liquid of the invention, peppermint glycol and the mutual mixture of Icaridin will not generate conflict, after peppermint glycol is compounded with Icaridin, compounding component can be made to be extended compared to effective mosquito repellent time of individual peppermint glycol or Icaridin, it can be synergistic.
Description
Technical field
The present invention relates to a kind of mosquito repellent products more particularly to a kind of peppermint glycol to combine with the mosquito repellent that Icaridin compounds
Object.
Background technique
Mosquito has become the serious public health problem in various countries.It is shown according to the investigation of WHO (World Health Organization), mosquito
It is to kill the most animal of the mankind, is up to 72.5 ten thousand people every year.2015, because the number of mosquito death is risen unexpectedly to 830,000 people.
Mosquito is the medium of infectious disease, and especially in torrid areas, multiple infectious disease is often transmitted to the mankind by mosquito, seriously endangers people
Body health.Currently, the means of prevention of mosquito harm mainly uses chemical insecticide and mosquito-repellent.But insecticide is a large amount of
The problems such as using drug resistance and environmental pollution is easily caused.And repellant is not direct killing mosquito, mainly prevents mosquito from stining
It stings, therefore pays much attention to its research both at home and abroad.Metadelphene (DEET), dimethyl phthalate, Icaridin (Icaridine) and peppermint two
The mosquito component of Disease Control and Prevention Center, the U.S. Chun Doushi (CDC) and Environmental Protection Agency (EPA) certification, wherein Icaridin and peppermint
Glycol shows higher safety and repellent activity, but repellant on the market is single dose mostly, and the lasting period is not
Very long, therefore, developing long-acting, the compound culicifuge of one kind becomes the main object of the present invention.
Peppermint glycol, abbreviation Meng's glycol, chemical name are to be used as the natural next of culicifuge to menthyl -3,8- glycol
Derived components have passed through European Union's biocide regulation.To human skin safety, repelling effect is good, is environmentally protective culicifuge.
On March 3rd, 2000 S.C.Johnson&son, Inc. company carries out the registration of terpane glycol pesticide in the U.S. first, registration
Product is 99% peppermint glycol raw medicine.Then, on March 31st, 2000, the peppermint glycol active constituent content of the said firm is
10% preparation obtains registration approval, is used for repellent mosquito, fly, midge etc. on the sprayable skin for being sprayed on the mankind of said preparation, clothes.
Icaridin is also known as Icaridin, and it is a kind of peace that chemical name, which is 2- (2- ethoxy) piperidines -1- sec-butyl carboxylate,
Entirely, pest repellant effectively, environmentally friendly.It will not directly kill insect, and being can be by the volatilization of smell, in lossless user
Insect is effectively driven in the case where health, allows user from the hardship of bite by mosquitos, and can replace that the smell is awful, viscosity is big
Metadelphene.Icaridin has proved to be effective pest repellant ingredient, in prevention and malaria control, Dengue Hemorrhagic Fever, yellow heat
It is played in terms of the high mortality insect-borne diseases such as disease, West Nile Virus, lime borreliosis (Lyme disease), tick-borne encephalitis important
Effect.In particular, it should be pointed out that the Icaridin Yi Huo World Health Organization (WHO) is recommended as effectively preventing to be stung by mosquito
Sting the diseases such as the malaria of propagation.
Summary of the invention
Aiming at the problems existing in the prior art, it is an object of that present invention to provide a kind of compounding drives efficient, without side-effects
Mosquito liquid.
The technical solution adopted by the present invention to solve the technical problems is: a kind of highly efficiency compositional mosquito repellent liquid, with peppermint glycol
It is active component with Icaridin.
Specifically, it is raw material that above-mentioned peppermint glycol, which is by the eucalyptus quintessence oil naturally extracted, under the catalytic action of acid
It arrives.
Specifically, above-mentioned peppermint glycol and Icaridin gross mass content are not less than 1%, and effective repellent time is not less than
0.5h。
Specifically, above-mentioned peppermint glycol and Icaridin gross mass content are not less than 10%, and effective repellent time is not small
In 3h.
Specifically, above-mentioned peppermint glycol and Icaridin gross mass content are not less than 18%, and effective repellent time is not small
In 4h.
Specifically, above-mentioned peppermint glycol and Icaridin gross mass content are not less than 26%, and effective repellent time is not small
In 6h.
Specifically, above-mentioned peppermint glycol is 1:99-99:1 with the mass ratio that compounds of Icaridin.
Specifically, above-mentioned peppermint glycol is 1:10-10:1 with the mass ratio that compounds of Icaridin.
Specifically, above-mentioned peppermint glycol is 1:4-4:1 with the mass ratio that compounds of Icaridin.
The invention has the following advantages: a kind of highly efficiency compositional mosquito repellent liquid of the invention, peppermint glycol and Icaridin
Mutual mixture will not generate conflict, after peppermint glycol is compounded with Icaridin, can make to compound component compared to individual peppermint
Effective mosquito repellent time of glycol or Icaridin is extended, can be synergistic.
A kind of highly efficiency compositional mosquito repellent liquid of the invention is not less than 18% in the gross mass content of peppermint glycol and Icaridin
When, effective repellent time up to 4h, with good application prospect.
Specific embodiment
The present invention will be described in detail with reference to embodiments.
Embodiment 1: the synthesis of effective component peppermint glycol
Lemon eucalyptus quintessence oil 3.5g is weighed in 100mL round-bottomed flask, oxalic acid 6.5mmol and water 30mL is then added,
It is reacted at 50 DEG C, gas-chromatography monitoring reaction, terminates reaction after 72h, be cooled to room temperature.After ethyl acetate extraction, organic phase
Saturated sodium bicarbonate aqueous solution and saturated common salt water washing are used respectively, and anhydrous sodium sulfate is dry, is spin-dried for after solvent up to peppermint two
Alcohol mother's medicine.
Certainly, the acquisition methods of peppermint glycol are not limited in this method, are also possible to other methods acquisition, can also be with
It is commercially available peppermint glycol product.
Embodiment 2:10% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 10g, double dealcoholization 20.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 3:10% Icaridin mosquito repellent liquid
It takes Icaridin 10.0g, double dealcoholization 20.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 5% peppermint glycol mosquito repellent liquid of embodiment 4:5% Icaridin
Peppermint glycol 5.0g is taken, Icaridin 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 5% citronellol mosquito repellent liquid of embodiment 5:5% Icaridin
Icaridin 5.0g is taken, citronellol 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% citronella oil mosquito repellent liquid of embodiment 6:5% Icaridin
Icaridin 5.0g is taken, citronella oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% caryophyllus oil mosquito repellent liquid of embodiment 7:5% Icaridin
Icaridin 5.0g is taken, caryophyllus oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% peppermint oil mosquito repellent liquid of embodiment 8:5% Icaridin
Icaridin 5.0g is taken, peppermint oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% lemon oil mosquito repellent liquid of embodiment 9:5% Icaridin
Icaridin 5.0g is taken, lemon oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% eucalyptus oil mosquito repellent liquid of embodiment 10:5% Icaridin
Icaridin 5.0g is taken, eucalyptus oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% jasmine oil mosquito repellent liquid of embodiment 11:5% Icaridin
Icaridin 5.0g is taken, jasmine oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% cinnamon oil mosquito repellent liquid of embodiment 12:5% Icaridin
Icaridin 5.0g is taken, cinnamon oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% attar of rose mosquito repellent liquid of embodiment 13:5% Icaridin
Icaridin 5.0g is taken, attar of rose 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% sandalwood oil mosquito repellent liquid of embodiment 14:5% Icaridin
Icaridin 5.0g is taken, sandalwood oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
+ 5% perilla herb oil mosquito repellent liquid of embodiment 15:5% Icaridin
Icaridin 5.0g is taken, perilla herb oil 5.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed to be
?.
Embodiment 16:1% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 1.0g, double dealcoholization 5.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 17:1% Icaridin mosquito repellent liquid
It takes Icaridin 1.0g, double dealcoholization 5.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 0.5% Icaridin mosquito repellent liquid of embodiment 18:0.5% peppermint glycol
Peppermint glycol 0.5g is taken, Icaridin 0.5g, double dealcoholization 5.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 0.7% Icaridin mosquito repellent liquid of embodiment 19:0.3% peppermint glycol
Peppermint glycol 0.3g is taken, Icaridin 0.7g, double dealcoholization 5.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 0.3% Icaridin mosquito repellent liquid of embodiment 20:0.7% peppermint glycol
Peppermint glycol 0.7g is taken, Icaridin 0.3g, double dealcoholization 5.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
Embodiment 21:5% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 5.0g, double dealcoholization 10.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 22:5% Icaridin mosquito repellent liquid
It takes Icaridin 5.0g, double dealcoholization 10.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 2.5% Icaridin mosquito repellent liquid of embodiment 23:2.5% peppermint glycol
Peppermint glycol 2.5g is taken, Icaridin 2.5g, double dealcoholization 10.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 3.5% Icaridin mosquito repellent liquid of embodiment 24:1.5% peppermint glycol
Peppermint glycol 1.5g is taken, Icaridin 3.5g, double dealcoholization 10.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 1.5% Icaridin mosquito repellent liquid of embodiment 25:3.5% peppermint glycol
Peppermint glycol 3.5g is taken, Icaridin 1.5g, double dealcoholization 10.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 9.9% Icaridin mosquito repellent liquid of embodiment 26:0.1% peppermint glycol
Peppermint glycol 0.1g is taken, Icaridin 9.9g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 0.1% Icaridin mosquito repellent liquid of embodiment 27:9.9% peppermint glycol
Peppermint glycol 9.9g is taken, Icaridin 0.1g, double dealcoholization 20.0g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 7% Icaridin mosquito repellent liquid of embodiment 28:3% peppermint glycol
Take peppermint glycol mother medicine 3.0g, Icaridin 7.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, mix
Uniformly to obtain the final product.
+ 3% Icaridin mosquito repellent liquid of embodiment 29:7% peppermint glycol
Take peppermint glycol mother medicine 7.0g, Icaridin 3.0g, double dealcoholization 20.0g are added water and complemented to 100.0g, mix
Uniformly to obtain the final product.
Embodiment 30:18% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 18.0g, double dealcoholization 24.8g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 31:18% Icaridin mosquito repellent liquid
It takes Icaridin 18.0g, double dealcoholization 24.8g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 9% Icaridin mosquito repellent liquid of embodiment 32:9% peppermint glycol
Peppermint glycol 9.0g is taken, Icaridin 9.0g, double dealcoholization 24.8g are added water and complemented to 100.0g, uniformly mixed
To obtain the final product.
+ 0.2% Icaridin mosquito repellent liquid of embodiment 33:17.8% peppermint glycol
Take peppermint glycol 17.8g, Icaridin 0.2g, double dealcoholization 24.8g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 17.8% Icaridin mosquito repellent liquid of embodiment 34:0.2% peppermint glycol
Take peppermint glycol 0.2g, Icaridin 17.8g, double dealcoholization 24.8g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 12% Icaridin mosquito repellent liquid of embodiment 35:6% peppermint glycol
Take peppermint glycol 6.0g, Icaridin 12.0g, double dealcoholization 24.8g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 6% Icaridin mosquito repellent liquid of embodiment 36:12% peppermint glycol
Take peppermint glycol 12.0g, Icaridin 6.0g, double dealcoholization 24.8g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
Embodiment 37:20% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 20.0g, double dealcoholization 27.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 38:20% Icaridin mosquito repellent liquid
It takes Icaridin 20.0g, double dealcoholization 27.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 10% Icaridin mosquito repellent liquid of embodiment 39:10% peppermint glycol
Take peppermint glycol 10.0g, Icaridin 10.0g, double dealcoholization 27.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 19.8% Icaridin mosquito repellent liquid of embodiment 40:0.2% peppermint glycol
Take peppermint glycol 0.2g, Icaridin 19.8g, double dealcoholization 27.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 0.2% Icaridin mosquito repellent liquid of embodiment 41:19.8% peppermint glycol
Take peppermint glycol 19.8g, Icaridin 0.2g, double dealcoholization 27.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 15% Icaridin mosquito repellent liquid of embodiment 42:5% peppermint glycol
Take peppermint glycol 5.0g, Icaridin 15.0g, double dealcoholization 27.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 5% Icaridin mosquito repellent liquid of embodiment 43:15% peppermint glycol
Take peppermint glycol 15.0g, Icaridin 5.0g, double dealcoholization 27.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
Embodiment 44:26% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 26.0g, double dealcoholization 33.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 45:26% Icaridin mosquito repellent liquid
It takes Icaridin 26.0g, double dealcoholization 33.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 13% Icaridin mosquito repellent liquid of embodiment 46:13% peppermint glycol
Take peppermint glycol 13.0g, Icaridin 13.0g, double dealcoholization 33.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 25.7% Icaridin mosquito repellent liquid of embodiment 47:0.3% peppermint glycol
Take peppermint glycol 0.3g, Icaridin 25.7g, double dealcoholization 33.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 0.3% Icaridin mosquito repellent liquid of embodiment 48:25.7% peppermint glycol
Take peppermint glycol 25.7g, Icaridin 0.3g, double dealcoholization 33.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 8.5% Icaridin mosquito repellent liquid of embodiment 49:17.5% peppermint glycol
Take peppermint glycol 17.5g, Icaridin 8.5g, double dealcoholization 33.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
+ 17.5% Icaridin mosquito repellent liquid of embodiment 50:8.5% peppermint glycol
Take peppermint glycol 8.5g, Icaridin 17.5g, double dealcoholization 33.0g are added water and complemented to 100.0g, and mixing is equal
It is even to obtain the final product.
Embodiment 51:30% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 30.0g, alcohol 36.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 52:30% Icaridin mosquito repellent liquid
It takes Icaridin 30.0g, alcohol 36.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 15% Icaridin mosquito repellent liquid of embodiment 53:15% peppermint glycol
It takes peppermint glycol 15.0g, Icaridin 15.0g, alcohol 36.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
+ 20% Icaridin mosquito repellent liquid of embodiment 54:10% peppermint glycol
It takes peppermint glycol 10.0g, Icaridin 20.0g, alcohol 36.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
+ 10% Icaridin mosquito repellent liquid of embodiment 55:20% peppermint glycol
It takes peppermint glycol 20.0g, Icaridin 10.0g, alcohol 36.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
Embodiment 56:40% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 40.0g, alcohol 42.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 57:40% Icaridin mosquito repellent liquid
It takes Icaridin 40.0g, alcohol 42.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 20% Icaridin mosquito repellent liquid of embodiment 58:20% peppermint glycol
It takes peppermint glycol 20.0g, Icaridin 20.0g, alcohol 42.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
+ 10% Icaridin mosquito repellent liquid of embodiment 59:30% peppermint glycol
It takes peppermint glycol 30.0g, Icaridin 10.0g, alcohol 42.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
+ 30% Icaridin mosquito repellent liquid of embodiment 60:10% peppermint glycol
It takes peppermint glycol 10.0g, Icaridin 30.0g, alcohol 42.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
Embodiment 61:50% peppermint glycol mosquito repellent liquid
It takes peppermint glycol 50.0g, alcohol 45.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
Embodiment 62:50% Icaridin mosquito repellent liquid
It takes Icaridin 50.0g, alcohol 45.0g to add water and complement to 100.0g, is uniformly mixed to obtain the final product.
+ 25% Icaridin mosquito repellent liquid of embodiment 63:25% peppermint glycol
It takes peppermint glycol 25.0g, Icaridin 25.0g, alcohol 45.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
+ 40% Icaridin mosquito repellent liquid of embodiment 64:10% peppermint glycol
It takes peppermint glycol 10.0g, Icaridin 40.0g, alcohol 45.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
+ 10% Icaridin mosquito repellent liquid of embodiment 65:40% peppermint glycol
It takes peppermint glycol 40.0g, Icaridin 10.0g, alcohol 45.0g to add water and complement to 100.0g, is uniformly mixed i.e.
?.
Test method of the present invention is as follows:
1. rat acute toxicity test
(1) given the test agent: 52 mosquito repellent liquid of embodiment
(2) animal subject: the explicitly first Sprague Dawley rat that grows up of selection strain, genetic background, 50, male and female
It is fifty-fifty, Female Body Weight 191.4~215.2g of range, 202.9~237.0g of male Body Weight range.
(3) test method: using probit method, if 5 dosage groups, dosage from low to high be respectively 1200.5,1715,
2450,3500,5000mg/kg, every group of 10 animals, half male and half female.Rat Septal night is deprived of food but not water before being administered, and animal diameter mouth fills
Stomach administration, close observation 4h after administration same day administration, there is toxic reaction and death condition in record animal, hereafter upper and lower daily
Noon is respectively observed once, until administration the 14th day.Animal before grouping, administration before, in the observation period every 7 days respectively weigh a weight.
The animal that dead animal and observation period terminate surviving during observation carries out gross anatomy, and tissue disease is done in visual inspection when having lesion
Neo-Confucianism checks.According to animal dead situation after administration, the half lethal dose of rat acute diameter mouth toxicity test and progress are obtained
Toxicity grading.
(4) test result: not observing abnormal clinical symptom, has no dead.Female, male SD rat half lethal dose
(LD50) > 5000mg/kg.
2. rat acute toxicity on inhalation is tested
(1) given the test agent: 52 mosquito repellent liquid of embodiment
(2) animal subject: the explicitly first Sprague Dawley rat that grows up of selection strain, genetic background, 10, male and female
It is fifty-fifty, Female Body Weight 210.3~241.3g of range, 270.8~323.8g of male Body Weight range.
(3) test method: using limitation method, chooses SD rat, and female, male each 5, while being exposed to design concentration and being
In the test sample aerosol environment of 2000mg/m3, duration 2h.It tests and uses systemic exposure dynamic formula contaminating mode, while into
Row concentration mensuration (filter membrane weighing method) and partial size (microscopic method) analysis.The parameter of register instrument equipment per hour during administration
(temperature, relative humidity, oxygen concentration, air inflow), operating condition, concentration mensuration result, particle size determination result simultaneously observe animal
Clinical response symptom carries out a clinical observation daily after administration, be observed continuously 14 days, observe and record the clinical symptoms of animal
And death condition.Before administration, administration after every 7 days and dissection before respectively weigh a weight of animals.All animals when off-test
Euthanasia carries out gross anatomy observation, and histopathologic examination should be done by having for visual inspection when lesion.According to the poison of animal
Property reaction and death condition, obtain LC50 and carry out toxicity grading.
(4) test result: have no dead without obvious poisoning symptom, in the observation period after animal subject contamination.Female, male SD is big
The half lethal concentration (LC50) of mouse systemic exposure toxicity on inhalation is all larger than 2000mg/m3。
3. repelling effect is tested
(1) worm kind and experimenter: sensitive aedes albopictus are tested, -5 days 3 days female insects that do not suck blood of sprouting wings；It is put in mosquito cage
Enter 300 test worms, tester's the back of the hand exposure 40mm × 40mm skin, rest part tightly covers.Hand is protruded into mosquito cage and is stopped
2min, close observation are stayed, discovery mosquito stops falling, and shake arm is expelled before its mouthpart will be pierced into skin, is denoted as 1 test worm
Stop falling.Tester of the test worm for stopping falling of coming more than 30 and test worm are that attack is qualified, and this person and this cage mosquito can carry out
Repellency test.
(2) repellency test: (men and women is fifty-fifty, and tests preceding and experimental period by the tester of 6 or so attack qualifications of selection
Between no drinking, tea or coffee, should not use the product of the class containing essence), respectively draw the skin of 50mm × 50mm in its both hands the back of the hand
Area a, wherein hand presses 1.5 μ L/cm2Dose uniformity smear culicifuge to be measured, exposure 40mm × 40mm skin therein
Skin, tightly covers rest part, and another hand is blank control.Culicifuge 2h is smeared, hand is protruded into the mosquito of attack qualification
2min in cage, observation comes to stop falling whether there is or not mosquito sucks blood.It tests later at interval of 1h once, as long as there is a mosquito to come to suck blood
Sentence and makees repellant failure.Record the effective protecting time (h) of repellant.Control hand first does check experiment every time, and attack closes
The test worm of lattice can continue to test, and test worm attack is unqualified, need replacing qualified test worm and tested.
(3) rating scale of pharmacodynamics index see the table below
The evaluation index of 1 mosquito repellent liquid of table
4. test result
The synergy result of study of 2 Icaridin of table and plant extract essential oil compounding
Repelling effect of the pure and mild Icaridin compounding mosquito repellent liquid of 3 peppermint of table two to aedes albopictus
As can be seen from the above table, after peppermint glycol is compounded with Icaridin, compared with single dose to aedes albopictus when walking quickly and keeping away
Between be significantly improved, illustrating can be synergistic after peppermint glycol is compounded with Icaridin；Toxicity test is the result shows that the compounding is driven
Mosquito liquid has no toxic side effect.
Taking the above-mentioned ideal embodiment according to the present invention as inspiration, through the above description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property range is not limited to the contents of the specification, it is necessary to which the technical scope thereof is determined according to the scope of the claim.
Claims (3)
1. a kind of highly efficiency compositional mosquito repellent liquid, it is characterised in that: using the pure and mild Icaridin of peppermint two as active component, the peppermint two
Alcohol and Icaridin gross mass content are not less than 18%, and effective repellent time is not less than 4h, the peppermint glycol and Ai Karui
The compounding mass ratio of fourth is 1:4-4:1.
2. a kind of highly efficiency compositional mosquito repellent liquid as described in claim 1, it is characterised in that: the peppermint glycol is by naturally extracting
Eucalyptus quintessence oil be raw material, obtained under the catalytic action of acid.
3. a kind of highly efficiency compositional mosquito repellent liquid as described in claim 1, it is characterised in that: the peppermint glycol and Icaridin are total
Mass content is not less than 26%, and effective repellent time is not less than 6h.
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Effective date of registration: 20191204 Address after: A2001, Liyuan business building, No. 4351, Dongbin Road, Lilin community, Nanshan street, Nanshan District, Shenzhen City, Guangdong Province Patentee after: Shenzhen quantum bio information technology Co., Ltd Address before: 213000 Changzhou Ninglu Biotechnology Co., Ltd. No. 2 Building, Dongfang Pioneer Park, 218 Fumin Road, Qishuyan District, Changzhou City, Jiangsu Province Patentee before: Changzhou Nimrod Biologica Technology Co., Ltd. |