CN106137780A - A kind of microcapsule containing dimethyl phthalate, mosquito-repellent water and preparation method thereof - Google Patents
A kind of microcapsule containing dimethyl phthalate, mosquito-repellent water and preparation method thereof Download PDFInfo
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- CN106137780A CN106137780A CN201610718660.2A CN201610718660A CN106137780A CN 106137780 A CN106137780 A CN 106137780A CN 201610718660 A CN201610718660 A CN 201610718660A CN 106137780 A CN106137780 A CN 106137780A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The invention provides a kind of microcapsule containing dimethyl phthalate, mosquito-repellent water and preparation method thereof.Microcapsule of the present invention includes dimethyl phthalate, chitosan and γ polyglutamic acid.The present invention utilizes chitosan and polyglutamic acid to wrap up dimethyl phthalate, itself and skin is kept apart, and reduces the stimulation to skin, and achieves slowly discharging of anophelifuge, makes repelling effect lasting.The main component of mosquito-repellent water of the present invention includes above-mentioned microcapsule containing dimethyl phthalate, Aloe extraction solution, hyaluronic acid, Polyethylene Glycol, propylene glycol, MEIGUI CHUNLU, water etc., has the effect such as moisturizing, antibacterial, anti-inflammatory anti-itch, safety non-toxic.Microcapsule preparation process of the present invention is simple, and wall material has recyclability and biodegradability, non-stimulated to skin.Mosquito-repellent water of the present invention utilizes microcapsule to be kept apart with skin by dimethyl phthalate, reduces untoward reaction；And dimethyl phthalate has been reached the purpose of slow release, and dimethyl phthalate concentration in astringent can be reduced, anophelifuge effective time is extended.
Description
Technical field
The present invention relates to daily chemical products field, be specifically related to a kind of mosquito-repellent water and preparation method thereof, especially a kind of containing driving
The microcapsule of mosquito ester, mosquito-repellent water and preparation method thereof.
Background technology
In daily life, the biting of mosquito is sucked blood and is brought a lot of trouble, the most then cause skin swollen itch rubescent, heavy then propagate disease
Evil of being critically ill is healthy, and therefore people are devoted to the research of mosquito control always.Currently used mosquito-repellent widely is to keep away
Mosquito amine (DEET), but people in use find that diethyltoluamide exists some problems, are first to have certain toxic and side effects, Ke Nengzao
Become user that the symptom such as erythema, urticaria occurs；Secondly chemical fibre class medicated clothing, paint there is certain dissolubility；3rd is right
Skin has certain permeability and zest.In view of these problems of diethyltoluamide, people begin look for renewal product, people
Finding that dimethyl phthalate is ideal substitute products, dimethyl phthalate has the spy such as broad-spectrum high efficacy, nontoxic non-stimulated, mosquito repellent time length
Point, the environment-friendly type repellant being well recognized as.Dimethyl phthalate is succeeded in developing by Merck KGaA company the earliest, is widely used in Europe, later
Succeeding in registration in U.S. Environmental Protection Agency (EPA) and World Health Organization (WHO) the most respectively, the successful registration in the two mechanism has promoted dimethyl phthalate to exist
Worldwide application.
Current key problem is to reduce absorption and the evaporation of anophelifuge, extends guard time, improves using effect.Practice
Showing, using slow release formulation is a kind of very effective method, and repellent activity composition temporarily " storage " can be got up by slow releasing agent, rises
To protection, reduce loss and allow it slowly disengage, reaching the purpose of long-acting mosquito repellent.Technology of Making Microcapsule i.e. up to
To above-mentioned purpose, i.e. use physics, chemically or physically chemistry and the method combined thereof, first former for repellant medicine high degree of dispersion is become
Superfine microgranule, then wraps up with macromolecular compound, forms microcapsule.Such as diethyltoluamide microcapsule, majority is with hydrophilic
Polyethylene is cyst material.Terpenoid microcapsule, with polyamide or different sulfur hydrocyanic ester as cyst material.Microcapsule technology has
Slow releasing function, can extend the effective time of repellant, improves protective rate, and can reduce the ill effect to people.
Publication No. a kind of anophelifuge viscose rayon that has been the patented invention of CN 103305953A, containing anophelifuge microcapsule, wherein
Used core just includes dimethyl phthalate, and capsule material is polyurethane, polyester, polyureas, polyamide or urea-formaldehyde resin, although this invention
Reach slow release effect, but capsule material used has been synthesis macromolecular material, relatively costly, do not have recyclability and biodegradable
Property, do not meet continuable development principle, and this invention is to prepare a kind of viscose rayon, be not suitable for the preparation of mosquito-repellent water.
Summary of the invention
Based on the deficiencies in the prior art, the invention provides a kind of microcapsule, mosquito-repellent water and preparation side thereof containing dimethyl phthalate
Method.
In order to realize foregoing invention purpose, the present invention provides techniques below scheme:
A kind of microcapsule, including dimethyl phthalate, chitosan and gamma-polyglutamic acid-.
Wherein, chitosan is the biopolymer that earth reserves are only second to cellulose, chitin deacetylation obtain, for
Known the only naturally cationic polysaccharide.The capsule of nano being made up of chitosan has increase medicine stability, improves biology
The features such as availability and reduction toxic and side effects.Gamma-polyglutamic acid-receive be fermentable produce glutamic acid polymer, be tool
There is the novel anionic macromolecular material of good biocompatibility, biodegradability, strong absorptive and reduced immunogenicity,
The medical domain such as aspect such as medicine controlled releasing, organizational project has a good application prospect.Formed by chitosan and gamma-polyglutamic acid-
Complex there is more preferable hydrophilic, cell compatibility and good mechanical performance, be the good of pesticide nano microcapsule wall material
Good selection.Additionally, chitosan itself also has preferable bacteriostatic activity.
Microcapsule of the present invention is wall material with dimethyl phthalate for microcapsule core, chitosan and gamma-polyglutamic acid-, by quiet
Chitosan/gamma-polyglutamic acid-the capsule of nano of electricity self-assembly method preparation load dimethyl phthalate.Utilize chitosan and polyglutamic acid pair
Dimethyl phthalate wraps up, and it is kept apart with skin, reduces the stimulation to skin, and achieves slowly discharging of anophelifuge,
Make repelling effect lasting.
Preferably, dimethyl phthalate described in described microcapsule is 1:(0.8 with the mass ratio of chitosan and gamma-polyglutamic acid-
～6): (0.4～5).
In some embodiments, described dimethyl phthalate is 1:2:1 with the mass ratio of chitosan and gamma-polyglutamic acid-.
In some embodiments, described dimethyl phthalate is 7:16:12 with the mass ratio of chitosan and gamma-polyglutamic acid-.
In some embodiments, described dimethyl phthalate is 1:2.4:2 with the mass ratio of chitosan and gamma-polyglutamic acid-.
In other embodiments, described dimethyl phthalate is 5:12:6 with the mass ratio of chitosan and gamma-polyglutamic acid-.
Present invention also offers the preparation method of described microcapsule, dimethyl phthalate is joined in chitosan-acetic acid solution molten
Solve, add gamma-polyglutamic acid-solution continuous stirring afterwards, be then centrifuged for collecting precipitation.
Preferably, the time of continuous stirring described in the preparation method of described microcapsule is 2-4h.
Preferably, it is centrifuged described in the preparation method of described microcapsule and is centrifuged 30min for 20000rpm.
Preferably, precipitate after water washs dry described in the preparation method of described microcapsule.
Present invention also offers a kind of mosquito-repellent water, including above-mentioned microcapsule.I.e. include load dimethyl phthalate chitosan/γ-
Polyglutamic acid capsule of nano.
Preferably, described mosquito-repellent water also includes propylene glycol, Polyethylene Glycol, hyaluronic acid, Aloe extraction solution, MEIGUI CHUNLU
And water.
Aloe extraction solution contains 22 kinds of aminoacid, mineral more than 17 kinds, constitutes nature moisturizing factor, can play moisturizing, disappear
Inflammation, activating cell and improve horny layer, delaying skin aging whitening, antiallergic.And MEIGUI CHUNLU have keep the skin wet, moisturizing,
Quickly antiinflammatory, antiallergic, antipruritic, slow down aging etc. act on, and it also gives the fragrance that product is happy simultaneously.
Preferably, by percentage to the quality, described mosquito-repellent water is composed of the following components: include above-mentioned microcapsule 15-25%,
Propylene glycol 15-20%, Polyethylene Glycol 0.5-2%, hyaluronic acid 3-7%, Aloe extraction solution 2-5%, MEIGUI CHUNLU 0.3-
0.7%, water is supplied.
In some embodiments, by percentage to the quality, described mosquito-repellent water is composed of the following components: include above-mentioned micro-glue
Capsule 25%, propylene glycol 20%, Polyethylene Glycol 2%, hyaluronic acid 5%, Aloe extraction solution 2%, MEIGUI CHUNLU 0.5%, water is supplied.
In some embodiments, by percentage to the quality, described mosquito-repellent water is composed of the following components: include above-mentioned micro-glue
Capsule 20%, propylene glycol 15%, Polyethylene Glycol 1.3%, hyaluronic acid 7%, Aloe extraction solution 3.5%, MEIGUI CHUNLU 0.7%, water
Supply.
In some embodiments, by percentage to the quality, described mosquito-repellent water is composed of the following components: include above-mentioned micro-glue
Capsule 15%, propylene glycol 18%, Polyethylene Glycol 0.5%, hyaluronic acid 3%, Aloe extraction solution 5%, MEIGUI CHUNLU 0.3%, water is mended
Foot.
In other embodiments, by percentage to the quality, described mosquito-repellent water is composed of the following components: include above-mentioned micro-
Capsule 22%, propylene glycol 18%, Polyethylene Glycol 1.5%, hyaluronic acid 4%, Aloe extraction solution 4%, MEIGUI CHUNLU 0.6%, water
Supply.
Present invention also offers the preparation method of described mosquito-repellent water, by propylene glycol, Polyethylene Glycol and water mix homogeneously, heating
Stirring, to being completely dissolved, is cooled to room temperature；It is subsequently adding hyaluronic acid and above-mentioned microcapsule, homogenizing；Add Aloe extraction solution and
MEIGUI CHUNLU, stirs.
Preferably, in the preparation method of described mosquito-repellent water, described in be heated to 70-80 DEG C.
Preferably, in the preparation method of described mosquito-repellent water, described homogenizing is 6000-8000rpm homogenizing 10-30min.
As shown from the above technical solution, the invention provides a kind of microcapsule, mosquito-repellent water and preparation side thereof containing dimethyl phthalate
Method.Microcapsule of the present invention includes dimethyl phthalate, chitosan and gamma-polyglutamic acid-.The present invention utilizes chitosan and polyglutamic acid
Dimethyl phthalate is wrapped up, itself and skin are kept apart, reduce the stimulation to skin, and achieve slowly releasing of anophelifuge
Put, make repelling effect lasting.The main component of mosquito-repellent water of the present invention includes that above-mentioned microcapsule containing dimethyl phthalate, Aloe are extracted
Liquid, hyaluronic acid, Polyethylene Glycol, propylene glycol, MEIGUI CHUNLU, water etc., have the effect such as moisturizing, antibacterial, anti-inflammatory anti-itch, safe nothing
Poison.
Compared with prior art, the present invention at least one of has the advantages that:
1) microcapsule preparation process is simple, and wall material used is natural macromolecular material, has recyclability and biology
Degradability, non-stimulated to skin, and chitosan has stronger bacteriostasis；
2) first dimethyl phthalate microcapsule is applied in anophelifuge cosmetics；
3) mosquito-repellent water of the present invention utilizes microcapsule to be kept apart with skin by dimethyl phthalate, reduce to skin bad instead
Should；And dimethyl phthalate has been reached the purpose of slow release, and dimethyl phthalate concentration in astringent can be reduced, anophelifuge effective time is prolonged
Long.Test display, the mosquito-repellent water containing dimethyl phthalate microcapsule of the present invention has good repellent effect, and guard time is
Mosquito-repellent water prepared by 15h, considerably longer than comparative example.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
In order to be further appreciated by the present invention, below in conjunction with specific embodiment, the present invention will be described in detail.As without special
Illustrating, microcapsule of the present invention and the raw material of mosquito-repellent water and experiment reagent are all bought by commercial channel and are obtained.As Aloe carries
Take liquid extract purchased from Guangzhou Sheng Jiya trade Co., Ltd, MEIGUI CHUNLU purchased from the Guangzhou Fang Dao cosmetics limited public affairs of science and technology
Department；Described water is preferably deionized water.
Embodiment 1:
1, the preparation of microcapsule: 4g dimethyl phthalate is joined the chitosan-acetic acid solution that 20mL mass concentration is 0.4g/mL,
It is sufficiently stirred for 2h under room temperature so that it is be completely dissolved, then adds the gamma-polyglutamic acid-that 10mL mass concentration is 0.4g/mL molten
Liquid continuous stirring 2h, is then centrifuged 30min in 20000rpm, removes supernatant, repeatedly washs gained precipitation with water, finally freezing
It is dried.
2, containing the mosquito-repellent water of dimethyl phthalate microcapsule:
Each composition is made up of the raw material of following mass percent: dimethyl phthalate microcapsule 25%, propylene glycol 20%, Polyethylene Glycol
2%, hyaluronic acid 5%, Aloe extraction solution 2%, MEIGUI CHUNLU 0.5%, deionized water is supplied.
Preparation method is: by propylene glycol, Polyethylene Glycol and water mix homogeneously, heats at 70 DEG C, and stirring is to being completely dissolved, cold
But room temperature is arrived；It is subsequently adding hyaluronic acid and dimethyl phthalate microcapsule, at 8000rpm homogenizing 30min；It is sequentially added into Aloe extraction solution
And MEIGUI CHUNLU, stir.
Embodiment 2:
1, the preparation of microcapsule: 7g dimethyl phthalate is joined the chitosan-acetic acid solution that 40mL mass concentration is 0.4g/mL,
It is sufficiently stirred for 3h under room temperature so that it is be completely dissolved, then adds the gamma-polyglutamic acid-that 30mL mass concentration is 0.4g/mL molten
Liquid continuous stirring 3h, is then centrifuged 30min in 20000rpm, removes supernatant, repeatedly washs gained precipitation with water, finally freezing
It is dried.
2, containing the mosquito-repellent water of dimethyl phthalate microcapsule:
Each composition is made up of the raw material of following mass percent: dimethyl phthalate microcapsule 20%, propylene glycol 15%, Polyethylene Glycol
1.3%, hyaluronic acid 7%, Aloe extraction solution 3.5%, MEIGUI CHUNLU 0.7%, deionized water is supplied.
Preparation method is: by propylene glycol, Polyethylene Glycol and water mix homogeneously, heats at 80 DEG C, and stirring is to being completely dissolved, cold
But room temperature is arrived；It is subsequently adding hyaluronic acid and dimethyl phthalate microcapsule, at 6000rpm homogenizing 10min；It is sequentially added into Aloe extraction solution
And MEIGUI CHUNLU, stir.
Embodiment 3:
1, the preparation of microcapsule: 10g dimethyl phthalate is joined the chitosan acetic acid that 60mL mass concentration is 0.4g/mL molten
Liquid, is sufficiently stirred for 4h under room temperature so that it is be completely dissolved, and then adds the gamma-polyglutamic acid-that 50mL mass concentration is 0.4g/mL
Solution continuous stirring 4h, is then centrifuged 30min in 20000rpm, removes supernatant, repeatedly washs gained precipitation with water, the coldest
Lyophilizing is dry.
2, containing the mosquito-repellent water of dimethyl phthalate microcapsule:
Each composition is made up of the raw material of following mass percent: dimethyl phthalate microcapsule 15%, propylene glycol 18%, Polyethylene Glycol
0.5%, hyaluronic acid 3%, Aloe extraction solution 5%, MEIGUI CHUNLU 0.3%, deionized water is supplied.
Preparation method is: by propylene glycol, Polyethylene Glycol and water mix homogeneously, heats at 75 DEG C, and stirring is to being completely dissolved, cold
But room temperature is arrived；It is subsequently adding hyaluronic acid and dimethyl phthalate microcapsule, at 7500rpm homogenizing 20min；It is sequentially added into Aloe extraction solution
And MEIGUI CHUNLU, stir.
Embodiment 4:
1, the preparation of microcapsule: 5g dimethyl phthalate is joined the chitosan-acetic acid solution that 30mL mass concentration is 0.4g/mL,
It is sufficiently stirred for 2.5h under room temperature so that it is be completely dissolved, then adds the gamma-polyglutamic acid-that 15mL mass concentration is 0.4g/mL
Solution continuous stirring 2.5h, is then centrifuged 30min in 20000rpm, removes supernatant, repeatedly washs gained precipitation with water, finally
Lyophilization.
2, containing the mosquito-repellent water of dimethyl phthalate microcapsule:
Each composition is made up of the raw material of following mass percent: dimethyl phthalate microcapsule 22%, propylene glycol 18%, Polyethylene Glycol
1.5%, hyaluronic acid 4%, Aloe extraction solution 4%, MEIGUI CHUNLU 0.6%, deionized water is supplied.
Preparation method is: by propylene glycol, Polyethylene Glycol and water mix homogeneously, heats at 75 DEG C, and stirring is to being completely dissolved, cold
But room temperature is arrived；It is subsequently adding hyaluronic acid and dimethyl phthalate microcapsule, at 8000rpm homogenizing 25min；It is sequentially added into Aloe extraction solution
And MEIGUI CHUNLU, stir.
Comparative example:
Each composition is made by the raw material of following mass percent: dimethyl phthalate 11.5%, ethanol 12%, propylene glycol 10%, thoroughly
Bright matter acid 3%, Aloe extraction solution 4%, MEIGUI CHUNLU 0.45%, deionized water is supplied.
Preparation method is: after dimethyl phthalate, ethanol, propylene glycol, water mix homogeneously, be sequentially added into hyaluronic acid, Aloe carries
Take liquid, MEIGUI CHUNLU, stir and get final product.
Test example: repelling effect is tested
Method with reference to standard GB/T/T 13917.9-2009 is carried out.Indoor conditions: temperature (26 ± 1) DEG C is the wettest
Degree (65 ± 10) %.Mosquito cage: long 400mm, wide 300mm, high 300mm.For examination worm kind and strain: Aedes albopictus (Aedes
Albopictus), Culex quinquefasciatus (Culex pipiens quinquefasciatus) and culex pipiens pallens (Culex
pipiens)。
(men and women half and half, and should not drink before test and during test to select 4 and the qualified tester of above attack
Tea or coffee, should not use the class containing essence to obtain product), wherein a back of the hand is blank, and comparison hands first does comparison survey every time
Examination, the examination worm that attack is qualified can continue test, and examination worm attack is defective, needs to change qualified examination worm and tests.Another
The back of the hand presses 1.5 μ L/cm2Dose uniformity smear mosquito-repellent water, and expose 4cm × 4cm skin of both hands, other parts tightly hide
Cover.Hands is stretched into 2min in attack qualified mosquito cage, if having a mosquito come to suck blood i.e. sentence make mosquito-repellent water lost efficacy.Often
0.5h detects once.Owing to Culex quinquefasciatus and culex pipiens pallens are mosquito kinds of sucking blood night, therefore indoor repellency test must at night or
The artificial dark surrounds arranged is carried out.Result is as shown in table 1
Repellent time (h) of the different mosquito-repellent water of table 1
| Group | Lineae ablicantes is according to mosquito | Culex quinquefasciatus | Culex pipiens pallens |
| Comparative example | 5 | 5.5 | 6.5 |
| Embodiment one | 10.5 | 12 | 13.5 |
| Embodiment two | 12 | 13.5 | 15 |
| Embodiment three | 11.5 | 12.5 | 14 |
| Embodiment four | 10 | 11.5 | 12.5 |
As shown in Table 1, the mosquito-repellent water containing dimethyl phthalate microcapsule of the present invention has good repellent effect, and guard time can
Up to the mosquito-repellent water prepared by 15h, considerably longer than comparative example.
Claims (10)
1. a microcapsule, including dimethyl phthalate, chitosan and gamma-polyglutamic acid-.
Microcapsule the most according to claim 1, it is characterised in that described dimethyl phthalate and chitosan and gamma-polyglutamic acid-
Mass ratio is 1:(0.8～6): (0.4～5).
3. the preparation method of microcapsule described in claim 1 or 2, it is characterised in that dimethyl phthalate is joined chitosan acetic acid molten
Liquid dissolves, adds gamma-polyglutamic acid-solution continuous stirring afterwards, be then centrifuged for collecting precipitation.
Preparation method the most according to claim 3, it is characterised in that the time of described continuous stirring is 2-4h；Described from
The heart is that 20000rpm is centrifuged 30min；Described precipitation is dried after water washs.
5. a mosquito-repellent water, including the microcapsule described in claim 1 or 2.
Mosquito-repellent water the most according to claim 5, it is characterised in that also include propylene glycol, Polyethylene Glycol, hyaluronic acid, reed
Luxuriant growth extracting solution, MEIGUI CHUNLU and water.
Mosquito-repellent water the most according to claim 6, it is characterised in that by percentage to the quality, described mosquito-repellent water is by following group
It is grouped into: include the microcapsule 15-25% described in claim 1 or 2, propylene glycol 15-20%, Polyethylene Glycol 0.5-2%, transparent
Matter acid 3-7%, Aloe extraction solution 2-5%, MEIGUI CHUNLU 0.3-0.7%, water is supplied.
8. the preparation method of mosquito-repellent water described in claim 5-7 any one, it is characterised in that by propylene glycol, Polyethylene Glycol and
Water mix homogeneously, heated and stirred, to being completely dissolved, is cooled to room temperature；It is subsequently adding described in hyaluronic acid and claim 1 or 2
Microcapsule, homogenizing；Add Aloe extraction solution and MEIGUI CHUNLU, stir.
Preparation method the most according to claim 8, it is characterised in that be heated to 70-80 DEG C.
Preparation method the most according to claim 8, it is characterised in that described homogenizing is 6000-8000rpm homogenizing 10-
30min。
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420510A (en) * | 2016-12-06 | 2017-02-22 | 广州睿森生物科技有限公司 | Mosquito-repelling liquid and preparation method thereof |
| CN106473990A (en) * | 2016-12-06 | 2017-03-08 | 广州睿森生物科技有限公司 | A kind of mosquito-driving liquid and preparation method thereof |
| CN106474010A (en) * | 2016-12-06 | 2017-03-08 | 广州睿森生物科技有限公司 | A kind of mosquito-driving liquid and preparation method thereof |
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| CN106473990B (en) * | 2016-12-06 | 2019-04-12 | 广州睿森生物科技有限公司 | A kind of mosquito repellent liquid and preparation method thereof |
| CN106473990A (en) * | 2016-12-06 | 2017-03-08 | 广州睿森生物科技有限公司 | A kind of mosquito-driving liquid and preparation method thereof |
| CN106474010A (en) * | 2016-12-06 | 2017-03-08 | 广州睿森生物科技有限公司 | A kind of mosquito-driving liquid and preparation method thereof |
| CN106420510A (en) * | 2016-12-06 | 2017-02-22 | 广州睿森生物科技有限公司 | Mosquito-repelling liquid and preparation method thereof |
| CN106474010B (en) * | 2016-12-06 | 2019-04-12 | 广州睿森生物科技有限公司 | A kind of mosquito repellent liquid and preparation method thereof |
| CN106420510B (en) * | 2016-12-06 | 2019-04-12 | 广州睿森生物科技有限公司 | A kind of mosquito repellent liquid and preparation method thereof |
| CN106614671A (en) * | 2016-12-28 | 2017-05-10 | 安徽紫檀科技有限公司 | Safe and environment-friendly mosquito repellent liquid and preparation method thereof |
| CN106614671B (en) * | 2016-12-28 | 2019-08-23 | 安徽紫檀科技有限公司 | Mosquito repellent liquid and preparation method thereof |
| CN109457487A (en) * | 2018-07-20 | 2019-03-12 | 广州天思品汇实业有限公司 | The preparation method of the mosquito-proof material of fabric, wearing product and the mosquito-proof material of fabric |
| CN109457487B (en) * | 2018-07-20 | 2021-07-30 | 广州天思品汇实业有限公司 | Mosquito-proof material for fabric, wearing article and preparation method of mosquito-proof material for fabric |
| CN110999907A (en) * | 2018-10-07 | 2020-04-14 | 南宁润生堂生物科技有限公司 | Microcapsule slow-release mosquito repellent containing menthanediol and 2-undecanone |
| CN114767579A (en) * | 2022-04-27 | 2022-07-22 | 成都彩虹电器（集团）股份有限公司 | Mosquito repellent liquid with slow release effect and preparation method thereof |
| CN114767579B (en) * | 2022-04-27 | 2024-02-06 | 成都彩虹电器（集团）股份有限公司 | Mosquito repellent liquid with slow release effect and preparation method thereof |
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