CN106596989A - Full-automatic immunization analyzer and detection method - Google Patents
Full-automatic immunization analyzer and detection method Download PDFInfo
- Publication number
- CN106596989A CN106596989A CN201710064722.7A CN201710064722A CN106596989A CN 106596989 A CN106596989 A CN 106596989A CN 201710064722 A CN201710064722 A CN 201710064722A CN 106596989 A CN106596989 A CN 106596989A
- Authority
- CN
- China
- Prior art keywords
- reagent card
- sampling
- detection
- incubation
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00524—Mixing by agitating sample carrier
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention relates to a full-automatic immunization analyzer and a detection method. The full-automatic immunization analyzer comprises a sample introduction device (1), a reagent card conveying device (2), a feeding mechanism (3), an incubation device (4), a puncture sampling assembly (5), a cleaning assembly (6), a discharging device (7), a detecting device (8), a plunger pump assembly (9) and a diaphragm pump assembly (10). The above modules are combined under control of a system control module and realize automatic immunoquantitative analysis of multiple samples through cooperation with each other so that detection efficiency is improved and requirements on a tester professional level are reduced.
Description
Technical field
The present invention relates to a kind of automatic lmunoassays analyzer and detection method, belong to the inspection of the immunoassays such as fluorescence and gold colloidal
Survey head of a bed diagnostic field.
Background technology
Full-automatic quantitative immunity analysis instrument, especially many full-automatic fluorescence immunity analyzers using rotating disk mechanism, just like
Lower deficiency：
1）The sample different in size for incubation time, analyser can only be analyzed by the unification of equal incubation time, cause behaviour
Make inconvenient and inefficiency；
2）The reagent that rotating disk mechanism is placed, interruption is transported to incubation mechanism, and waiting time length is inefficient, such as patent application
CN201410836485.8 discloses a kind of full-automatic fluorescence coulometric analyses device and implementation method, and its reaction disk module 4 is to turn
Disk mode, not only volume is big, and it is long to react the waiting time；Patent application CN201510289808.0 discloses a kind of three-dimensional fixed
Position rotating disc type entry dry type fluorescence detector, it is equally placed on test card in test card carrier, entering using rotating disk
Row test, the spacing existed between reagent card is big, and reaction efficiency inadequate problem when the carousel mode is arranged, is between draw-in groove
Radial setting, takes volume larger.
3）The usual volume of general fluorescent quantitative detector is larger in prior art, carries inconvenient, is not easy to inspection immediately
Test, limit it and having inconvenient traffic, the development of under-developed area.
4）When carrying out quantitative fluorescence analysis in prior art, addition reagent manually is needed, operating process is complicated, for operation
The level requirement of person is higher, meanwhile, condition is harsh, and easy misoperation causes result incorrect, meanwhile, in prior art
When detecting to reagent card, mobile reagent card itself is needed, easily cause the precise decreasing of testing result.
Due to antigen-antibody combination and marker material it is relatively costly, it is impossible to chemical reagent equally make large area show
How color, and background has the impurity such as water, blood, marker material to cause to permeate the uneven difficulty and precision that increased detection, exist
Keep the volume of POCT products small, the stability and susceptiveness of detection is improved while easy to carry and efficiency is improved, be this
Technical field problem demanding prompt solution.
The content of the invention
For achieving the above object, in the present invention, can be according to during incubation in existing Full-automatic quantitative immunity analysis instrument structure
Between length intelligence is full-automatic successively realizes detection, due to incubation when overcoming existing Full-automatic quantitative immunity analysis instrument comprehensive detection
The drawbacks of time difference such as needs to wait at the inefficiency.
At least 3 kinds 10 kinds of pattern detection can once be loaded to begin a project, being capable of the precise control response time.From the beginning of sample-adding
Terminate to detection, the response time is consistent, be loaded high precision, sample-adding progress can be according to setting item by system prompt.In addition, sample and
Detection project with independent assortment, according to sample needs, can carry out the independent assortment of disparity items and different samples, improve
Detection efficiency.
It is an object of the present invention to provide a kind of quick accurate detection patient blood（Whole blood or composition blood）And in other samples
Cause of disease mark, for the diagnosis of the various diseases especially common emergency case of emergency treatment and serious symptom, easy to operate efficiently realization is complete
Automatization's immune quantitative detection means.
To solve above-mentioned technical problem：The application proposes a kind of automatic lmunoassays analyzer, including sampling assemble（5）, it is clear
Wash component（6）, incubating device（4）And detection means（8）, the detection means（8）Positioned at the incubating device（4）Top, institute
State incubating device（4）Including line slideway 407, incubation monitor station 409, on the incubation monitor station 409 at least two are provided with
Parallel reagent draw-in groove, the incubation monitor station 409 can move linearly along the line slideway 407 or so；The detection means
（8）Including line slideway 806, detection head 804, the detection means（8）Detection head 804 before and after the line slideway 806
Rectilinear movement；The line slideway 407 is mutually perpendicular to the line slideway 806；The detection means（8）Incubation is completed
Reagent card is detected.
The incubating device can be kept（4）In reagent card maintain static to detect to it, the cleaning assembly（6）
Agitating device to mix cup in liquid fully mixed, and can using cleaning device to sampling assemble（5）In take
Sample pin is cleaned.
Described automatic lmunoassays analyzer, wherein, the sampling assemble（5）Can according to the automatic direct sample of program setting or from
Resampling after dynamic puncture.
Described automatic lmunoassays analyzer, wherein, the detection means（8）With the sampling device（1）Positioned at straight line
The both sides of guide rail 407 or the same side positioned at line slideway 407.
Described automatic lmunoassays analyzer, wherein, the incubating device（4）For movable incubating device, also including temperature control
Electronic module 410, the temperature control electronic module 410 is located at the bottom surface of the incubation monitor station 409, can be with the incubation monitor station
409 movements, for controlling the temperature of the incubation monitor station 409.
Described automatic lmunoassays analyzer, wherein, the incubating device（4）Also include motor 401, synchronous belt 402,
Near-end induction apparatuss 403, sensing chip 404, bearing 405, distal end induction apparatuss 406, slide block 408, the near-end induction apparatuss 403, distal end
Induction apparatuss 406 are arranged at the two ends of the line slideway 407, and the synchronous belt 402 is located at the side of the line slideway 407
While be arrangeding in parallel, the incubation monitor station 409 is fixedly installed on the top of the slide block 408, and by the snapping of the slide block 408
On the line slideway 407, the motor 401 drives the action of the synchronous belt 402.
Described automatic lmunoassays analyzer, wherein, the sampling device（1）Including test tube rack 101, bearing 104, initial
Level sensor 105, motor 107, terminal induction apparatuss 108 and the multiple samples 102, sample being positioned in the test tube rack 101
Or buffer 103, the bearing 104 places the linear platform of plane of the test tube rack 101, in the entry position of linear platform
Initial sensor 105 is set, baffle plate is set in the end of linear platform, and terminal induction apparatuss 108, institute are set in the lower end of baffle plate
The side that motor 107 is arranged at the linear platform is stated, its connection simultaneously band action of moving gear 106, the gear 106 is arranged at institute
The bottom of linear platform is stated, gear 106 is intermeshed with the tooth-like part of test tube rack bottom.
Described automatic lmunoassays analyzer, wherein, the detection means（8）Including removable detection head, the inspection
Gauge head includes at least one fluoroscopic examination head, gold colloidal detection head.
The detection means（8）Also include motor 801, screw mandrel 802, screw mandrel mother set 803, slide block 805, sensing chip 807, sense
Device 808, motor mounting plate 809, bearing 810 are answered, the screw mandrel 802 controls the detection head 804 under the driving of motor 801
Move along the tandem of line slideway 806, to detect to the reagent card being incubated, the induction apparatuss 808 are used to sense inspection
The positional information of gauge head, the detection head 804 is higher than the incubation monitor station 409.
Described automatic lmunoassays analyzer, wherein, the cleaning assembly（6）Including mixing cup 602, Washing cup 610, institute
State mixing cup 602, Washing cup 610 placed side by side, described mixing 602 pairs of sampling assembles of cup（5）The several samples of taking-up are entered
Row is mixed, 610 pairs of sampling assembles of the Washing cup（5）All cleaned after per sub-sampling.
Described automatic lmunoassays analyzer, wherein, the cleaning assembly（6）Also include cleanout fluid import 601, supporting slice
603rd, waste liquid outlet 604, magnetic couplings mixing component 605, motor 606, support 607, waste liquid outlet 608, cleanout fluid import
609, the supporting slice 603 is used to fix the cleanout fluid import 601, and the waste liquid outlet 604 is located at the mixing cup 602
Bottom, the cleanout fluid import 609 is arranged at the side of Washing cup 610, and the waste liquid outlet 608 is arranged at the Washing cup
610 bottom, magnetic couplings mixing component 605 pairs mixes cup 602 and is stirred mixing.
Described automatic lmunoassays analyzer, wherein, the sampling assemble（5）Including portal frame 518, puncture sampling probe
513rd, part, horizontal balance part are moved up and down, the horizontal balance part drives puncture sampling probe 513 to move forward and backward, described
Up and down action part drives puncture sampling probe 513 to move up and down and is sampled, and the horizontal balance part is located at the portal frame
On 518 cross bar.
Described automatic lmunoassays analyzer, wherein, the up and down action part includes moving up and down motor 501, ball
Screw mandrel 510, slide block 511, sensing chip 512；The horizontal balance part includes moving horizontally motor 502, synchronous belt 503, straight
Line guide rail 504, induction apparatuss 505, bevel gear set 506, splined shaft 507, sensing chip 508, induction apparatuss 509；In the up and down action
The bottom of part arranges cleaning chamber 514, rinse liquid outlet 515, cleanout fluid import 516, and the sampling probe 513 is carried out clearly
Wash, code reader 517 is set in the montant bottom of the portal frame 518.
Described automatic lmunoassays analyzer, wherein, also including reagent card conveyer device（2）And feeding structure（3）, it is described
Reagent card conveyer device（2）Multiple reagent cards are moved in parallel into the feeding structure（3）, the feeding structure（3）Successively will
Each of the plurality of reagent card is pushed to the correspondence position of the incubation monitor station 409.
Described automatic lmunoassays analyzer, wherein, the reagent card conveyer device（2）Including motor 201, synchronous belt
202nd, drive pulley wheel assembly 203, belt 204, cover plate 205, support 206, code reader 207, width and the examination of the belt 204
The length of agent card matches, and the cover plate 205 is covered in the top of the belt 204 with the holding certain intervals of the belt 204,
The certain intervals, less than the width of reagent card, read to state yard device 207 positioned at the cover plate more than or equal to the thickness of reagent card
The side of 205 porch, and higher than the cover plate 205, for the information of reading reagent card.
Described automatic lmunoassays analyzer, wherein, the feeding structure（3）Including motor 301, synchronous belt 302, slide
Block 303, guide rail 304, pusher pole 305, sensing chip 306, induction apparatuss 307, the pusher pole 305 is moved along guide rail 304,
For pushing the correspondence position that reagent snaps into the incubation monitor station 409, the sensing chip 306 is protected with the position of pusher pole 305
Hold consistent, detect the position of sensing chip 306 by induction apparatuss 307 to judge the position of pusher pole 305.
Described automatic lmunoassays analyzer, wherein, also including device for discharging（7）, the device for discharging（7）Including bearing
701st, motor 702, screw mandrel 703, nut sleeve 704, discharge arm 705, near-end induction apparatuss 706, sensing chip 707, distal end induction apparatuss
708th, spent reagent disposable box 709, the screw mandrel 703 is driven the discharge arm 705, and the discharge arm 705 promotes spent reagent to institute
In stating spent reagent disposable box 709, by the near-end induction apparatuss 706, sensing chip 707, distal end induction apparatuss 708 discharging is sensed
The positional information of bar 705, the sensing chip 707 is arranged on the discharge arm 705, and both holding positions are consistent.
Described automatic lmunoassays analyzer, wherein, also including assembly of the plunger pump（9）, bellows pumping element（10）, the post
Plug pump group part（9）Including bearing 901, motor 902, plunger displacement pump 903, pump inlet 904, pump discharge 905, electromagnetic valve 906；It is described every
Membrane pump component（10）Including bearing 101, barrier film waste drains pump 102, barrier film liquid feeding pump 103, electromagnetic valve 104, electromagnetic valve 105, according to setting
Determine program, system control assembly of the plunger pump（9）, bellows pumping element（10）And respective line, puncturing sampling probe can be between each position
Sample, buffer, cleanout fluid are quantitatively drawn or inject, can also suck go out again after air residual liquid in pin, and make to give up
Liquid injects waste liquid recovery apparatus.
A kind of detection method of automatic lmunoassays analyzer, comprises the steps：
（1）Setting detection information, by the reagent card that need to be detected incubating device is fixed on（4）In, a reagent card is fixed in often addition,
Incubating device（4）Move right a segment distance along straight line；
（2）Addition sample information, by sampling assemble（5）Sample is sampled, the buffer fully mixing extracted is processed
Pass through sampling assemble afterwards or directly（5）It is added to the incubating device（4）Reagent card in；
（3）Incubation control, according to the temperature requirements of each reagent card, by incubating device（4）In temperature control electronic module carry out
Temperature control, and be incubated according to the different response time；
（4）Testing result feedback of the information, keeps reagent card motionless, detection means（8）Motion detection 804, to reaching regulation
The reagent card of incubation time is detected, and result is fed back to into system control device；
（5）Discharging, after the completion of detection, by device for discharging（7）Carry out discharging.
The detection method of described automatic lmunoassays analyzer, wherein, the step（1）In specifically include：From reagent card
Conveyer device（2）Reagent card is placed in porch, and just whether code reader 207 reads the information of the reagent card placed, and judge information
Really, if incorrect, alert, if correctly, by reagent card conveyer device（2）Convey multiple reagents to snap into
Feeding structure（3）In, the feeding structure（3）Each pushed successively in the plurality of reagent card arrives the incubating device
（4）Fixed position；Or the direct reagent card by needs detection is manually inserted into the incubating device（4）Fixed position in.
The detection method of described automatic lmunoassays analyzer, wherein, the step（2）In specifically include：The sampling
Component（5）Can be according to program setting from sampling device（1）In automatic resampling after direct sample or automatic puncturing, will sampling sample
Originally in being positioned over mixing cup 602, after every sub-sampling, by sampling assemble（5）Puncture sampling probe 513 be placed in Washing cup 610
Row cleaning, until all of sample extraction is completed, will mix the sample in cup 602 and is mixed, then by puncturing sampling probe
The sample of mixing is added to the incubating device by 513（4）Reagent card in be incubated.
The detection method of described automatic lmunoassays analyzer, wherein, the step（3）In specifically include：The temperature control
Electronic module 410 is in incubating device（4）Incubation monitor station 409 bottom snapped at a temperature of demand with adjusting reagent, it is described
Detection means（8）Reception system control device realizes that intelligences combination is efficient successively for the incubation time information of each reagent card
Ground detection.
A kind of Full-automatic quantitative immunity analysis instrument of the present invention has the advantage that：
1）Under the control of system control module, sampling device, incubating device, sampler, data acquisition unit, reagent clamp
Put and combined with system control module, each device cooperates, realize jointly and carry out automatically immune quantitative point
The purpose of analysis.
2）This instrument punctures sampling assemble can be according to resampling after the automatic direct sample of program setting or automatic puncturing.
3）Only project to be measured need to be set in system, instrument is sequentially placed required reagent, is not required to shake by sample prompting
It is even, uncap, the operation such as pre-dilution, you can start automatic detection analysis and output result.
4）By using cleaning device, the use of medical disposable material is eliminated, operating cost is reduced, environmental protection；Pass through
The agitating device mixed in the motor drive mixing cup that cup bottom is arranged carries out fully mixing etc. to mixing the liquid in cup.Each portion
Part cooperates under control system control, co-ordination, realizes instrument intelligent prompt and false alarm, further increases this
The automaticity and performance of analyser.
5）Reagent card is maintained static, and core detection head can be detected along guide rail rectilinear movement in detection means, compared with it
He can reach higher accuracy of detection by mobile reagent card, by mobile detection head, keep stablizing for reagent card, reduces reagent card and moves
It is dynamic to cause the change such as reaction environment, temperature to cause reaction result error occur.
6）A kind of quantitative immunological detection method of the present invention, using above-mentioned automatic lmunoassays analyzer, to various samples
Existing automatic intelligent instrumental quantitative analysis are realized, detection range is expanded, detection efficiency is improve, and to the special of tester
Industry level reduces requirement.
7）Incubation reaction platform is set to the mode of rectilinear movement, structure is relative to the disk of prior art in the present invention
Mode is simpler, meanwhile, being arranged by adjacent parallel mode between draw-in groove, disk is into radial setting in hinge structure
The obvious volume of mode of draw-in groove is much smaller, and the analyser for making the present invention is easy to carry, and the application is skilful by the design of multiple structures
It is wonderful, make accuracy of detection higher, using effect is projected.
8）Due to the raising of accuracy of detection, using the reduction of volume, the cost of equipment is greatly reduced.
Description of the drawings
Fig. 1 is automatic lmunoassays analyzer internal structure schematic diagram；
Fig. 2 is sampling device structural representation；
Fig. 3 is reagent card transport conveyor constructions schematic diagram；
Fig. 4 is feeding mechanism schematic diagram；
Fig. 5 is movable incubating device structural representation；
Fig. 6 is puncture sampling assemble structural representation；
Fig. 7 cleans part structural representation to mix；
Fig. 8 is device for discharging structural representation；
Fig. 9 is structure of the detecting device schematic diagram；
Figure 10 is assembly of the plunger pump structural representation；
Figure 11 is bellows pumping element structural representation.
Specific embodiment
The application is described in further detail below in conjunction with the accompanying drawings, it is necessary to it is pointed out here that, implement in detail below
Mode is served only for being further detailed the application, it is impossible to be interpreted as the restriction to the application protection domain, the field
Technical staff can make some nonessential modifications and adaptations to the application according to above-mentioned application content.
Embodiment one：
As shown in figure 1, proposing a kind of automatic lmunoassays analyzer, including sampling device for the application（1）, reagent card conveyer device
（2）, feed mechanism（3）, incubating device（4）, puncture sampling assemble（5）, cleaning assembly（6）, device for discharging（7）, detection means
（8）, assembly of the plunger pump（9）, bellows pumping element（10）.
It is illustrated in figure 2 sampling device structural representation, the sampling device（1）Including test tube rack 101, bearing 104, just
Beginning level sensor 105, motor 107, terminal induction apparatuss 108 and the multiple samples 102 being positioned in the test tube rack 101, examination
Sample or buffer 103, the bearing 104 places the linear platform of plane of the test tube rack 101, in the entrance position of linear platform
Initial sensor 105 is installed, baffle plate is set in the end of linear platform, and terminal induction apparatuss 108 are set in the lower end of baffle plate,
The motor 107 is arranged at the side of the linear platform, and its connection simultaneously band action of moving gear 106, the gear 106 is arranged at
The bottom of the linear platform, gear 106 is intermeshed with the tooth-like part of test tube rack bottom.
Reagent card transport conveyor constructions schematic diagram is illustrated in figure 3, feeding structure schematic diagram is illustrated in figure 4, wherein, also
Including reagent card conveyer device（2）And feeding structure（3）, the reagent card conveyer device（2）Multiple reagent cards are moved in parallel
To the feeding structure（3）, the feeding structure（3）Successively each by the plurality of reagent card is pushed to the incubation inspection
The correspondence position of scaffold tower 409.
Wherein, the reagent card conveyer device（2）Including motor 201, synchronous belt 202, drive pulley wheel assembly 203,
Belt 204, cover plate 205, support 206, code reader 207；The code reader 207 is arranged at reagent card conveyer device（2）Side,
And higher than the cover plate 205.The feeding structure（3）Including motor 301, synchronous belt 302, slide block 303, guide rail 304, pusher
Pole 305, sensing chip 306, induction apparatuss 307, the pusher pole 305 is moved along guide rail 304, for pushing reagent to necessarily
Position, the sensing chip 306 is consistent with the position of pusher pole 305, and by induction apparatuss 307 position of sensing chip 306 is detected
Put to judge the position of pusher pole 305.
The motor 301 is arranged on the side of guide rail 304, and guide rail 304 may be selected to be cylindrical column, and motor 301 rotates
Synchronous belt 302, the synchronous belt 302 is driven to drive the pusher pole 305 to move along cylindrical column, induction apparatuss
307 are arranged on the end of guide rail 304, and the slide block 303 is arranged on the lower end of pusher pole 305.
The width of the belt 204 matches with the length of reagent card, and the cover plate 205 keeps one with the belt 204
What is be spaced calmly is covered in the top of the belt 204, and the certain intervals are more than or equal to the thickness of reagent card, less than reagent card
Width, reads to state side of yard device 207 positioned at the porch of the cover plate 205, and higher than the cover plate 205, for reading examination
The information of agent card, the cover plate 205 adopts transparent material, and can be used for observation makes reagent card move as requested, can prevent again
Dirt waterproof.
As shown in figure 5, be movable incubating device structural representation, the incubating device（4）Including line slideway 407, incubate
Monitor station 409 is educated, the incubation monitor station 409 can move linearly along the line slideway 407 or so, the detection means（8）
Detection head 804 by along the tandem of the line slideway 806 movement, the incubating device can be kept（4）In reagent card
Maintain static to detect it.
The incubating device（4）Also include motor 401, synchronous belt 402, near-end induction apparatuss 403, sensing chip 404, bearing
405th, distal end induction apparatuss 406, slide block 408 (not identifying in figure), temperature control electronic module 410, the near-end induction apparatuss 403, distal end
Induction apparatuss 406 are arranged at the two ends of the line slideway 407, and the synchronous belt 402 is located at the side of the line slideway 407
While be arrangeding in parallel, the incubation monitor station 409 is fixedly installed on the top of the slide block 408, while being detained by the slide block 408
It is connected on the line slideway 407, the motor 401 drives the action of the synchronous belt 402, enables incubation monitor station 409
Along line slideway or so linear motion.The near-end induction apparatuss 403, sensing chip 404, the sensing incubation detection of distal end induction apparatuss 406
The positional information of platform 409, the sensing chip 404 is used for the position on the line slideway 407 of mark incubation monitor station.
Puncture sampling assemble schematic diagram is illustrated in figure 6, wherein, the sampling assemble（5）Including portal frame 518, puncture
Sampling probe 513, up and down action part, horizontal balance part, the horizontal balance part drives to puncture and move before and after sampling probe 513
Dynamic, the up and down action part drives puncture sampling probe 513 to move up and down and is sampled, and the horizontal balance part is located at described
On the cross bar of portal frame 518.
The up and down action part includes moving up and down motor 501, screw mandrel 510, slide block 511, sensing chip 512；The water
Flat action component include move horizontally motor 502, synchronous belt 503, line slideway 504, induction apparatuss 505, bevel gear set 506,
Splined shaft 507, sensing chip 508, induction apparatuss 509；It is described to move up and down the cross bar that motor 501 is arranged on the portal frame 518
One end, it is described to move horizontally the position that motor 502 arranges the wherein one vertical top and cross bar handing-over of the portal frame 518
Put, the line slideway 504 be arranged in parallel with cross bar, the induction apparatuss 505 arrange the downside of line slideway 504 near wherein one
Montant position, the induction apparatuss 509 are arranged on the left side of the splined shaft 507 near upper position, for sensing the sensing
Piece 512.In the bottom of the up and down action part, cleaning chamber 514, rinse liquid outlet 515, cleanout fluid import 516 are set, it is right
The sampling probe 513 is cleaned, and in the montant bottom of the portal frame 518 code reader 517 is arranged.
Puncture sampling probe 513 end is installed on the slide block 511, and can be in the presence of the slide block 511 up and down
Movement is punctured, and the slide block 511 is installed on the ball screw 510, and can be in the screw mandrel 510 and synchronous belt
Make the puncture sampling probe 513 in sampling position, buffer storehouse in the presence of 503, mix switching between cup and loading position, it is described to wear
Thorn sampling probe 513 passes through the cleaning chamber 514；The code reader 517 is arranged at the lower end of the vertical bar of the portal frame 518
Portion.The sampling assemble（5）Can be according to resampling after the automatic direct sample of program setting or automatic puncturing.
Mixing cleaning assembly schematic diagram is illustrated in figure 7, wherein, the cleaning assembly（6）Including mixing cup 602, cleaning
Cup 610, the mixing cup 602, Washing cup 610 are placed side by side, described mixing 602 pairs of sampling assembles of cup（5）That what is taken out is more
Plant sample to be mixed, 610 pairs of sampling assembles of the Washing cup（5）All cleaned after per sub-sampling.
The cleaning assembly（6）Also include cleanout fluid import 601, supporting slice 603, the stirring of waste liquid outlet 604, magnetic couplings
Component 605, motor 606, support 607, waste liquid outlet 608, cleanout fluid import 609, the supporting slice 603 is used to fix described clear
Washing liquid import 601, the waste liquid outlet 604 is located at the bottom of the mixing cup 602, and the cleanout fluid import 609 is arranged at clearly
The side of cup 610 is washed, the waste liquid outlet 608 is arranged at the bottom of the Washing cup 610, magnetic couplings mixing component 605 pairs
Mix cup 605 and be stirred mixing.
The cleaning assembly（6）Agitating device to mix cup in liquid fully mixed, and can using cleaning
Device is cleaned to mixing cup, the puncture sampling assemble（5）After can be according to the automatic direct sample of program setting or automatic puncturing
Resampling.
Device for discharging schematic diagram is illustrated in figure 8, wherein, also including device for discharging（7）, the device for discharging（7）Including
Bearing 701, motor 702, ball screw 703, ball nut set 704, discharge arm 705, near-end induction apparatuss 706, sensing chip 707,
Distal end induction apparatuss 708, spent reagent disposable box 709.The ball screw 703 is driven the discharge arm 705, the discharge arm 705
Spent reagent is promoted in the spent reagent disposable box 709, by the near-end induction apparatuss 706, sensing chip 707, distal end induction apparatuss
The positional information of the 708 sensings discharge arm 705, the sensing chip 707 is arranged on the discharge arm 705, both holding positions
Put consistent.The detection means（8）With the sampling device（1）Positioned at the both sides of line slideway 407 or positioned at line slideway 407
The same side.
Structure of the detecting device schematic diagram is illustrated in figure 9, wherein, the detection means（8）Also include motor 801, screw mandrel
802nd, screw mandrel mother set 803, slide block 805, sensing chip 807, induction apparatuss 808, motor mounting plate 809, bearing 810, the screw mandrel 802
Under the driving of motor 801, control the detection head 804 and move along the tandem of line slideway 806, with to the reagent being incubated
Card is detected that the induction apparatuss 08, induction apparatuss 808 are used to sense the positional information of detection head, and the detection head 804 is higher than institute
State incubation monitor station 409.
The detection head is quantitative fluorescence analysis detection head, for carrying out fluoroscopic examination to reagent card.
It is as shown in Figure 10 assembly of the plunger pump schematic diagram, is as shown in figure 11 bellows pumping element schematic diagram, wherein, also include
Assembly of the plunger pump（9）, bellows pumping element（10）, the assembly of the plunger pump（9）Overall is in upper and lower arrangement, from bottom to top successively
For bearing 901, motor 902, plunger displacement pump 903, pump inlet 904, pump discharge 905, electromagnetic valve 906, wherein, the bearing 901, electricity
Machine 902, plunger displacement pump 903 are fixed by elongated plates, and the electromagnetic valve 906 is arranged at the side position of elongated plates upper end
Put；The bellows pumping element（10）Including bearing 101, barrier film waste drains pump 102, barrier film liquid feeding pump 103, electromagnetic valve 104, electromagnetic valve
105, the barrier film waste drains pump 102, barrier film liquid feeding pump 103 are parallel side by side, and the electromagnetic valve 104, electromagnetic valve 105 are parallel side by side,
It is arranged on barrier film waste drains pump 102, the top of the parallel juxtaposed positions of barrier film liquid feeding pump 103.The assembly of the plunger pump（9）It is a kind of fixed
Amount pump, by corresponding electromagnetic valve open and close on component, achievable puncture sampling probe calibrated shot goes out liquid also can quantitatively suck liquid
Body, can also suck go out again after air residual liquid in pin, the bellows pumping element（10）It is a kind of micropump, group can be passed through
Corresponding electromagnetic valve open and close on part so as to flow out after intraluminal liquid pressing.According to setting program, system control assembly of the plunger pump
（9）, bellows pumping element（10）And respective line, puncturing sampling probe can quantitatively draw or inject sample, buffering between each position
Liquid, cleanout fluid, can also suck go out again after air residual liquid in pin, and make waste liquid inject waste liquid recovery apparatus
A kind of detection method of automatic lmunoassays analyzer, comprises the steps：
（1）Setting detection information, by the reagent card that need to be detected incubating device is fixed on（4）In, a reagent card is fixed in often addition,
Incubating device（4）Move right a segment distance along straight line；
（2）Addition sample information, by sampling assemble（5）Sample is sampled, by Extraction buffer etc. and fully at mixing
After reason or directly by sampling assemble（5）It is added to the incubating device（4）Reagent card in；
（3）Incubation control, according to the temperature requirements of each reagent card, by incubating device（4）In temperature control electronic module carry out
Temperature control, and be incubated according to the different response time；
（4）Testing result feedback of the information, keeps reagent card motionless, detection means（8）Motion detection 804, to reaching regulation
The reagent card of incubation time is detected, and result is fed back to into system control device；
（5）Discharging, after the completion of detection, by device for discharging（7）Carry out discharging.
The detection method of described automatic lmunoassays analyzer, wherein, the step（1）In specifically include：From reagent card
Conveyer device（2）Reagent card is placed in porch, and just whether code reader 207 reads the information of the reagent card placed, and judge information
Really, if incorrect, alert, if correctly, by reagent card conveyer device（2）Convey multiple reagents to snap into
Feeding structure（3）In, the feeding structure（3）Each pushed successively in the plurality of reagent card arrives the incubating device
（4）Fixed position；Or the direct reagent card by needs detection is manually inserted into the incubating device（4）Fixed position in.
The detection method of described automatic lmunoassays analyzer, wherein, the step（2）In specifically include：The sampling
Component（5）Can be according to program setting from sampling device（1）In automatic resampling after direct sample or automatic puncturing, will sampling sample
Originally in being positioned over mixing cup 602, after every sub-sampling, by sampling assemble（5）Puncture sampling probe 513 be placed in Washing cup 610
Row cleaning, until all of sample extraction is completed, will mix the sample in cup 602 and is mixed, then by puncturing sampling probe
The sample of mixing is added to the incubating device by 513（4）Reagent card in be incubated.
The detection method of described automatic lmunoassays analyzer, wherein, the step（3）In specifically include：The temperature control
Electronic module 410 is in incubating device（4）Incubation monitor station 409 bottom snapped at a temperature of demand with adjusting reagent, it is described
Detection means（8）Reception system control device is for the incubation time information of each reagent card.When incubation reaches the stipulated time, move
Make detection head forward movement, detect reacted information and feed back to system control device, after having detected, detection head is moved rearwards by
Reset.
Embodiment two：
Detection means（8）Including detection head, the detection head can be changed manually, and the detection head can select gold colloidal detection head,
For carrying out gold colloidal detection, other structures or part are identical with fluorescence detection device.
A kind of automatic lmunoassays analyzer of the present invention has the advantage that：1）Under the control of system control module, enter
Sampling device, incubating device, sampler, data acquisition unit, reagent card device and system control module are organically combined one
Rise, each device cooperates, and realize jointly carries out the purpose of immune quantitative analysis automatically.
2）This instrument punctures sampling assemble can be according to resampling after the automatic direct sample of program setting or automatic puncturing.
3）Only project to be measured need to be set in system, instrument is sequentially placed required reagent, is not required to shake by sample prompting
It is even, uncap, the operation such as pre-dilution, you can start automatic detection analysis and output result.
4）By using cleaning device, the use of medical disposable material is eliminated, operating cost is reduced, environmental protection；Pass through
The agitating device mixed in the motor drive mixing cup that cup bottom is arranged carries out fully mixing etc. to mixing the liquid in cup.Each portion
Part cooperates under control system control, co-ordination, realizes instrument intelligent prompt and false alarm, further increases this
The automaticity and performance of analyser.
5）Reagent card is maintained static, and core detection head can be detected along guide rail rectilinear movement in detection means, compared with it
He can reach higher accuracy of detection by mobile reagent card, by mobile detection head, keep stablizing for reagent card, reduces reagent card and moves
It is dynamic to cause the change such as reaction environment, temperature to cause reaction result error occur.
6）A kind of quantitative immunological detection method of the present invention, using above-mentioned automatic lmunoassays analyzer, to various samples
Automatic intelligent instrumental quantitative analysis are realized, detection range is expanded, detection efficiency is improve, and to the specialty of tester
Level reduces requirement.
7）Incubation reaction platform is set to the mode of rectilinear movement, structure is relative to the disk of prior art in the present invention
Mode is simpler, meanwhile, being arranged by adjacent parallel mode between draw-in groove, disk is into radial setting in hinge structure
The obvious volume of mode of draw-in groove is much smaller, and the analyser for making the present invention is easy to carry, and the application is skilful by the design of multiple structures
It is wonderful, make accuracy of detection higher, using effect is projected.
8）Due to the raising of accuracy of detection, using the reduction of volume, the cost of equipment is greatly reduced.
The application includes but is not limited to concrete actuator described in accompanying drawing, transmission and controlling organization, inductive switch,
As transmission can use chain, rack-and-pinion, or can be all to be made within the spirit and principles in the present invention using other drivings etc.
Any modification, equivalent and improvement etc., should be included within the scope of the present invention.
Claims (21)
1. a kind of automatic lmunoassays analyzer, it is characterised in that：Including sampling assemble（5）, cleaning assembly（6）, incubating device（4）
And detection means（8）, the detection means（8）Positioned at the incubating device（4）Top, the incubating device（4）Including straight line
Guide rail 407, incubation monitor station 409, on the incubation monitor station 409 at least two parallel reagent draw-in grooves are provided with, described to incubate
Educating monitor station 409 can move linearly along the line slideway 407 or so；The detection means（8）Including line slideway 806, inspection
Gauge head 804, the detection means（8）Detection head 804 along the tandem of the line slideway 806 move；The line slideway
407 are mutually perpendicular to the line slideway 806；The detection means（8）The reagent card that incubation is completed is detected.
2. automatic lmunoassays analyzer as claimed in claim 1, it is characterised in that：The sampling assemble（5）Can set according to program
Resampling after fixed automatic direct sample or automatic puncturing.
3. automatic lmunoassays analyzer as claimed in claim 2, it is characterised in that：The detection means（8）With the sample introduction
Device（1）Positioned at the both sides of the line slideway 407 or the same side positioned at line slideway 407.
4. automatic lmunoassays analyzer as claimed in claim 1, it is characterised in that：The incubating device（4）For movable incubation
Device, also including temperature control electronic module 410, the temperature control electronic module 410 is located at the bottom surface of the incubation monitor station 409, uses
In the temperature for controlling the incubation monitor station 409.
5. automatic lmunoassays analyzer as claimed in claim 4, it is characterised in that：The incubating device（4）Also include motor
401st, synchronous belt 402, near-end induction apparatuss 403, sensing chip 404, bearing 405, distal end induction apparatuss 406, slide block 408, it is described near
End induction apparatuss 403, distal end induction apparatuss 406 are arranged at the two ends of the line slideway 407, and the synchronous belt 402 is located at institute
The side for stating line slideway 407 be arranged in parallel, and the incubation monitor station 409 is fixedly installed on the top of the slide block 408, and leads to
Cross the slide block 408 to snap onto on the line slideway 407, the motor 401 drives the action of the synchronous belt 402.
6. automatic lmunoassays analyzer as claimed in claim 1, it is characterised in that：Also include sampling device（1）, the sample introduction
Device（1）Including test tube rack 101, bearing 104, initial level sensor 105, motor 107, terminal induction apparatuss 108 and it is positioned over
Multiple samples 102, sample or buffer 103 in the test tube rack 101, the bearing 104 places the flat of the test tube rack 101
The linear platform in face, in the entry position of linear platform initial sensor 105 is arranged, and in the end of linear platform baffle plate is arranged,
And terminal induction apparatuss 108 are set in the lower end of baffle plate, the motor 107 is arranged at the side of the linear platform, and its connection is simultaneously
The band action of moving gear 106, the gear 106 is arranged at the dentation of the bottom of the linear platform, gear 106 and test tube rack bottom
Portion is intermeshed.
7. automatic lmunoassays analyzer as claimed in claim 1, it is characterised in that：The detection means（8）Including replaceable
Detection head, the detection head includes at least one fluoroscopic examination head, gold colloidal detection head.
8. automatic lmunoassays analyzer as claimed in claim 7, it is characterised in that：The detection means（8）Also include motor
801st, screw mandrel 802, screw mandrel mother set 803, slide block 805, sensing chip 807, induction apparatuss 808, motor mounting plate 809, bearing 810, institute
Screw mandrel 802 is stated under the driving of motor 801, the detection head 804 is controlled and is moved along the tandem of line slideway 806, with to incubating
The reagent card educated is detected that the induction apparatuss 808 are used to sense the positional information of detection head, and the detection head 804 is higher than
The incubation monitor station 409.
9. automatic lmunoassays analyzer as claimed in claim 1, it is characterised in that：The cleaning assembly（6）Including mixing cup
602nd, Washing cup 610, the mixing cup 602, Washing cup 610 are placed side by side, described mixing 602 pairs of sampling assembles of cup（5）
The several samples of taking-up are mixed, 610 pairs of sampling assembles of the Washing cup（5）All cleaned after per sub-sampling.
10. automatic lmunoassays analyzer as claimed in claim 9, it is characterised in that：The cleaning assembly（6）Also include cleaning
Liquid import 601, supporting slice 603, waste liquid outlet 604, magnetic couplings mixing component 605, motor 606, support 607, waste liquid outlet
608th, cleanout fluid import 609, the supporting slice 603 is used to fix the cleanout fluid import 601, and the waste liquid outlet 604 is located at
The bottom for mixing cup 602, the cleanout fluid import 609 is arranged at the side of Washing cup 610, and the waste liquid outlet 608 sets
The bottom of the Washing cup 610 is placed in, magnetic couplings mixing component 605 pairs mixes cup 602 and is stirred mixing.
11. automatic lmunoassays analyzers as claimed in claim 1, it is characterised in that：The sampling assemble（5）Including portal frame
518th, puncture sampling probe 513, move up and down part, horizontal balance part, the horizontal balance part drives and punctures sampling probe 513
Movable, the up and down action part drives puncture sampling probe 513 to move up and down and is sampled, the horizontal balance part position
On the cross bar of the portal frame 518.
12. automatic lmunoassays analyzers as claimed in claim 11, it is characterised in that：The up and down action part includes upper and lower
Mobile motor 501, screw mandrel 510, slide block 511, sensing chip 512；The horizontal balance part includes moving horizontally motor 502, same
Step belt 503, line slideway 504, induction apparatuss 505, bevel gear set 506, splined shaft 507, sensing chip 508, induction apparatuss 509；
The bottom for moving up and down part arranges cleaning chamber 514, rinse liquid outlet 515, cleanout fluid import 516, to the sampling
Pin 513 is cleaned, and in the montant bottom of the portal frame 518 code reader 517 is arranged.
13. automatic lmunoassays analyzers as claimed in claim 1, it is characterised in that：Also include reagent card conveyer device（2）With
Feeding structure（3）, the reagent card conveyer device（2）Multiple reagent cards are moved in parallel into the feeding structure（3）, it is described enter
Material structure（3）Successively each by the plurality of reagent card is pushed to the correspondence position of the incubation monitor station 409.
14. automatic lmunoassays analyzers as claimed in claim 13, it is characterised in that：The reagent card conveyer device（2）Bag
Include motor 201, synchronous belt 202, drive pulley wheel assembly 203, belt 204, cover plate 205, support 206, code reader 207, institute
The length of the width and reagent card of stating belt 204 matches, and the cover plate 205 keeps covering for certain intervals with the belt 204
Cover on the top of the belt 204, the certain intervals, less than the width of reagent card, are read more than or equal to the thickness of reagent card
Side of yard device 207 positioned at the porch of the cover plate 205 is stated, and higher than the cover plate 205, for the letter of reading reagent card
Breath.
15. automatic lmunoassays analyzers as claimed in claim 13, it is characterised in that：The feeding structure（3）Including motor
301st, synchronous belt 302, slide block 303, guide rail 304, pusher pole 305, sensing chip 306, induction apparatuss 307, the pusher pole
305 move along guide rail 304, for pushing the correspondence position that reagent snaps into the incubation monitor station 409, the sensing chip 306
It is consistent with the position of pusher pole 305, detects the position of sensing chip 306 to judge pusher pole 305 by induction apparatuss 307
Position.
16. automatic lmunoassays analyzers as claimed in claim 1, it is characterised in that：Also include device for discharging（7）, it is described to unload
Material device（7）Including bearing 701, motor 702, screw mandrel 703, nut sleeve 704, discharge arm 705, near-end induction apparatuss 706, sensing chip
707th, distal end induction apparatuss 708, spent reagent disposable box 709, the ball screw 703 is driven the discharge arm 705, the discharge arm
705 promote spent reagent in the spent reagent disposable box 709, are sensed by the near-end induction apparatuss 706, sensing chip 707, distal end
Device 708 senses the positional information of the discharge arm 705, and the sensing chip 707 is arranged on the discharge arm 705, and both keep
Position consistency.
17. automatic lmunoassays analyzers as claimed in claim 1, it is characterised in that：Also include assembly of the plunger pump（9）, barrier film
Pump group part（10）, the assembly of the plunger pump（9）Including bearing 901, motor 902, plunger displacement pump 903, pump inlet 904, pump discharge
905th, electromagnetic valve 906；The bellows pumping element（10）Including bearing 101, barrier film waste drains pump 102, barrier film liquid feeding pump 103, electromagnetism
Valve 104, electromagnetic valve 105, according to setting program, system control assembly of the plunger pump（9）, bellows pumping element（10）And respective line, wear
Thorn sampling probe can quantitatively be drawn between each position or inject sample, buffer, cleanout fluid, can also suck after air and go out again
Residual liquid in pin, and make waste liquid inject waste liquid recovery apparatus.
A kind of 18. detection methods of automatic lmunoassays analyzer, it is characterised in that：
（1）Setting detection information, by the reagent card that need to be detected incubating device is fixed on（4）In, a reagent card is fixed in often addition,
Incubating device（4）Move right a segment distance along straight line；
（2）Addition sample information, by sampling assemble（5）Sample is sampled, the buffer fully mixing extracted is processed
Pass through sampling assemble afterwards or directly（5）It is added to the incubating device（4）Reagent card in；
（3）Incubation control, according to each reagent card temperature requirements, by incubating device（4）In temperature control electronic module carry out temperature
Degree control, and be incubated according to the different response time；
（4）Testing result feedback of the information, keeps reagent card motionless, detection means（8）Motion detection 804, to reaching regulation
The reagent card of incubation time is detected, and result is fed back to into system control device；
（5）Discharging, after the completion of detection, by device for discharging（7）Carry out discharging.
The detection method of 19. automatic lmunoassays analyzers as claimed in claim 18, it is characterised in that：The step（1）In
Specifically include：From reagent card conveyer device（2）Reagent card is placed in porch, and code reader 207 reads the information of the reagent card placed,
And judge whether information is correct, and if incorrect, alert, if correctly, by reagent card conveyer device（2）
Convey multiple reagents and snap into feeding structure（3）In, the feeding structure（3）Each in the plurality of reagent card is pushed successively
To the incubating device（4）Fixed position；Or the direct reagent card by needs detection is manually inserted into the incubating device（4）
Fixed position in.
The detection method of 20. automatic lmunoassays analyzers as claimed in claim 18, it is characterised in that：The step（2）In
Specifically include：The sampling assemble（5）Can be according to program setting from sampling device（1）In automatically after direct sample or automatic puncturing
Resampling, the sample of sampling is positioned in mixing cup 602, after every sub-sampling, by sampling assemble（5）Puncture sampling probe 513
It is placed in Washing cup 610 and is cleaned, until all of sample extraction is completed, the sample in cup 602 will be mixed and mixed, so
Afterwards the sample of mixing is added to into the incubating device by puncturing sampling probe 513（4）Reagent card in be incubated.
The detection method of 21. automatic lmunoassays analyzers as claimed in claim 18, it is characterised in that：The step（3）In
Specifically include：The temperature control electronic module 410 is in incubating device（4）Incubation monitor station 409 bottom snapped into adjusting reagent
At a temperature of demand, the detection means（8）Reception system control device is realized for the incubation time information of each reagent card
Intelligences combination is efficiently detected successively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710064722.7A CN106596989B (en) | 2017-02-05 | 2017-02-05 | A kind of automatic lmunoassays analyzer and detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710064722.7A CN106596989B (en) | 2017-02-05 | 2017-02-05 | A kind of automatic lmunoassays analyzer and detection method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106596989A true CN106596989A (en) | 2017-04-26 |
| CN106596989B CN106596989B (en) | 2019-03-01 |
Family
ID=58586586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710064722.7A Active CN106596989B (en) | 2017-02-05 | 2017-02-05 | A kind of automatic lmunoassays analyzer and detection method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106596989B (en) |
Cited By (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106932601A (en) * | 2017-05-02 | 2017-07-07 | 深圳市活水床旁诊断仪器有限公司 | A kind of Biochemical Analyzer and its detection method |
| CN106970026A (en) * | 2017-05-02 | 2017-07-21 | 深圳市活水床旁诊断仪器有限公司 | A kind of biochip cartridge and its operating method |
| CN107490703A (en) * | 2017-08-02 | 2017-12-19 | 南京岚煜生物科技有限公司 | A kind of multichannel Immunofluorescence test device |
| CN107525922A (en) * | 2017-09-21 | 2017-12-29 | 苏州新波生物技术有限公司 | A kind of updraft type magnetic bead transfer device and its magnetic bead transfer method |
| CN107807249A (en) * | 2017-10-26 | 2018-03-16 | 迈克医疗电子有限公司 | Solve lock set, sample transfer device and its control method |
| CN108333381A (en) * | 2018-02-28 | 2018-07-27 | 深圳市锐拓仪器设备有限公司 | A kind of digestion instrument automatic sampling device |
| CN108333178A (en) * | 2018-02-07 | 2018-07-27 | 爱威科技股份有限公司 | Clinical samples analysis method and clinical samples analyzer |
| CN108362901A (en) * | 2018-02-09 | 2018-08-03 | 深圳市活水床旁诊断仪器有限公司 | A kind of chemiluminescence immune assay device and its analysis method |
| CN108490205A (en) * | 2018-04-10 | 2018-09-04 | 深圳市博辰智控有限公司 | A kind of microwell plate sample adding system and method |
| CN108717113A (en) * | 2018-05-29 | 2018-10-30 | 陈金凤 | A kind of bio-chemical detector |
| CN108732363A (en) * | 2018-07-13 | 2018-11-02 | 深圳市活水床旁诊断仪器有限公司 | A kind of fluoroimmunoassay device and its control method |
| CN108970660A (en) * | 2018-07-16 | 2018-12-11 | 云旗（南京）生物技术有限公司 | A kind of experiment reagent extraction and its mixing arrangement |
| CN109061212A (en) * | 2018-08-14 | 2018-12-21 | 三诺生物传感股份有限公司 | A kind of Biochemical Analyzer |
| CN109061213A (en) * | 2018-09-07 | 2018-12-21 | 四川沃文特生物技术有限公司 | A kind of device for liquid feeding |
| CN109116011A (en) * | 2018-09-26 | 2019-01-01 | 安徽贝驰生物科技有限公司 | A kind of quantitative liquid detection device |
| CN109364804A (en) * | 2018-09-25 | 2019-02-22 | 珠海丽珠试剂股份有限公司 | A kind of incubation oscillation device |
| CN109490299A (en) * | 2018-09-04 | 2019-03-19 | 广东朗源生物科技有限公司 | A kind of portable mycotoxin colloidal gold detector and application method |
| CN109628441A (en) * | 2018-12-07 | 2019-04-16 | 山东森芃生物科技有限公司 | A kind of full-automatic nucleic acid purifier |
| CN110053057A (en) * | 2019-04-28 | 2019-07-26 | 深圳市万臣科技有限公司 | Liquid relief component |
| CN110297101A (en) * | 2019-07-30 | 2019-10-01 | 南京岚煜生物科技有限公司 | The method of the automatic sample machine and automatic sample of sample adding device and pipeline system detection |
| CN110488002A (en) * | 2019-08-30 | 2019-11-22 | 重庆康巨全弘生物科技有限公司 | A kind of device for immunochromatography convenient for adding liquid |
| CN110967496A (en) * | 2018-09-29 | 2020-04-07 | 深圳市帝迈生物技术有限公司 | Sample analyzer |
| CN111257556A (en) * | 2018-11-30 | 2020-06-09 | 深圳市帝迈生物技术有限公司 | Immunoassay analyzer and sample analysis method |
| CN111474360A (en) * | 2020-05-18 | 2020-07-31 | 四川新健康成生物股份有限公司 | Dry-type fluorescence immunoassay appearance |
| CN112345746A (en) * | 2021-01-08 | 2021-02-09 | 南京澳林生物科技有限公司 | Modularized full-automatic biochemical analyzer and use method thereof |
| CN112793879A (en) * | 2021-04-13 | 2021-05-14 | 苏州长光华医生物医学工程有限公司 | Device for automatically puncturing cover |
| CN113203602A (en) * | 2021-05-24 | 2021-08-03 | 重庆医科大学附属第一医院 | Sampling device for medical examination |
| CN113341129A (en) * | 2021-06-10 | 2021-09-03 | 禾柏(南京)医学科技有限公司 | Fluorescence immunoassay device and control method |
| CN113376393A (en) * | 2021-07-09 | 2021-09-10 | 广州蓝勃生物科技有限公司 | Full-automatic immunoassay analyzer and detection method |
| WO2022068523A1 (en) * | 2020-09-29 | 2022-04-07 | 江苏百英吉生命科学技术有限公司 | Detection system for detecting biological fluid sample |
| WO2022166051A1 (en) * | 2021-02-04 | 2022-08-11 | 南京宝沃生物科技有限公司 | Fully automatic wb incubation system |
| CN116413460A (en) * | 2021-12-31 | 2023-07-11 | 力合科技（湖南）股份有限公司 | Automatic solution analysis device |
| CN117434280A (en) * | 2023-12-21 | 2024-01-23 | 广州誉康医药有限公司 | Reagent card selecting and puncturing system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009085616A (en) * | 2007-09-27 | 2009-04-23 | Olympus Corp | Automatic analyzer, and dispensation control method of liquid sample in automatic analyzer |
| CN203310842U (en) * | 2013-06-06 | 2013-11-27 | 江苏克莱斯克生物技术有限公司 | Full-automatic blood bank system |
| CN204302296U (en) * | 2014-12-10 | 2015-04-29 | 深圳市汇研科创生物科技有限公司 | Cuvette transport mechanism |
| WO2015183800A1 (en) * | 2014-05-29 | 2015-12-03 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for reducing carryover of reagents and samples in analytical testing |
| CN105572407A (en) * | 2016-01-27 | 2016-05-11 | 广州万孚生物技术股份有限公司 | Full-automatic fluorescent quantitative immunity analyzer and detection method |
-
2017
- 2017-02-05 CN CN201710064722.7A patent/CN106596989B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009085616A (en) * | 2007-09-27 | 2009-04-23 | Olympus Corp | Automatic analyzer, and dispensation control method of liquid sample in automatic analyzer |
| CN203310842U (en) * | 2013-06-06 | 2013-11-27 | 江苏克莱斯克生物技术有限公司 | Full-automatic blood bank system |
| WO2015183800A1 (en) * | 2014-05-29 | 2015-12-03 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for reducing carryover of reagents and samples in analytical testing |
| CN204302296U (en) * | 2014-12-10 | 2015-04-29 | 深圳市汇研科创生物科技有限公司 | Cuvette transport mechanism |
| CN105572407A (en) * | 2016-01-27 | 2016-05-11 | 广州万孚生物技术股份有限公司 | Full-automatic fluorescent quantitative immunity analyzer and detection method |
Cited By (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106970026A (en) * | 2017-05-02 | 2017-07-21 | 深圳市活水床旁诊断仪器有限公司 | A kind of biochip cartridge and its operating method |
| CN106932601A (en) * | 2017-05-02 | 2017-07-07 | 深圳市活水床旁诊断仪器有限公司 | A kind of Biochemical Analyzer and its detection method |
| CN107490703A (en) * | 2017-08-02 | 2017-12-19 | 南京岚煜生物科技有限公司 | A kind of multichannel Immunofluorescence test device |
| CN107525922A (en) * | 2017-09-21 | 2017-12-29 | 苏州新波生物技术有限公司 | A kind of updraft type magnetic bead transfer device and its magnetic bead transfer method |
| CN107807249B (en) * | 2017-10-26 | 2024-05-24 | 迈克医疗电子有限公司 | Unlocking assembly, sample transferring device and control method thereof |
| CN107807249A (en) * | 2017-10-26 | 2018-03-16 | 迈克医疗电子有限公司 | Solve lock set, sample transfer device and its control method |
| CN108333178A (en) * | 2018-02-07 | 2018-07-27 | 爱威科技股份有限公司 | Clinical samples analysis method and clinical samples analyzer |
| CN108362901A (en) * | 2018-02-09 | 2018-08-03 | 深圳市活水床旁诊断仪器有限公司 | A kind of chemiluminescence immune assay device and its analysis method |
| CN108362901B (en) * | 2018-02-09 | 2024-02-27 | 深圳市活水床旁诊断仪器有限公司 | Chemiluminescence immunoassay device and method |
| CN108333381A (en) * | 2018-02-28 | 2018-07-27 | 深圳市锐拓仪器设备有限公司 | A kind of digestion instrument automatic sampling device |
| CN108490205A (en) * | 2018-04-10 | 2018-09-04 | 深圳市博辰智控有限公司 | A kind of microwell plate sample adding system and method |
| CN108717113A (en) * | 2018-05-29 | 2018-10-30 | 陈金凤 | A kind of bio-chemical detector |
| CN108732363A (en) * | 2018-07-13 | 2018-11-02 | 深圳市活水床旁诊断仪器有限公司 | A kind of fluoroimmunoassay device and its control method |
| CN108732363B (en) * | 2018-07-13 | 2023-10-24 | 深圳市活水床旁诊断仪器有限公司 | Fluorescence immunoassay device |
| CN108970660A (en) * | 2018-07-16 | 2018-12-11 | 云旗（南京）生物技术有限公司 | A kind of experiment reagent extraction and its mixing arrangement |
| CN109061212A (en) * | 2018-08-14 | 2018-12-21 | 三诺生物传感股份有限公司 | A kind of Biochemical Analyzer |
| WO2020034613A1 (en) * | 2018-08-14 | 2020-02-20 | 三诺生物传感股份有限公司 | Biochemical analyzer |
| CN109490299A (en) * | 2018-09-04 | 2019-03-19 | 广东朗源生物科技有限公司 | A kind of portable mycotoxin colloidal gold detector and application method |
| CN109061213A (en) * | 2018-09-07 | 2018-12-21 | 四川沃文特生物技术有限公司 | A kind of device for liquid feeding |
| CN109364804A (en) * | 2018-09-25 | 2019-02-22 | 珠海丽珠试剂股份有限公司 | A kind of incubation oscillation device |
| CN109116011A (en) * | 2018-09-26 | 2019-01-01 | 安徽贝驰生物科技有限公司 | A kind of quantitative liquid detection device |
| CN109116011B (en) * | 2018-09-26 | 2024-03-19 | 安徽贝驰生物科技有限公司 | Quantitative liquid detection device |
| CN110967496A (en) * | 2018-09-29 | 2020-04-07 | 深圳市帝迈生物技术有限公司 | Sample analyzer |
| CN110967496B (en) * | 2018-09-29 | 2023-11-10 | 深圳市帝迈生物技术有限公司 | sample analyzer |
| CN111257556A (en) * | 2018-11-30 | 2020-06-09 | 深圳市帝迈生物技术有限公司 | Immunoassay analyzer and sample analysis method |
| CN109628441A (en) * | 2018-12-07 | 2019-04-16 | 山东森芃生物科技有限公司 | A kind of full-automatic nucleic acid purifier |
| CN110053057A (en) * | 2019-04-28 | 2019-07-26 | 深圳市万臣科技有限公司 | Liquid relief component |
| CN110053057B (en) * | 2019-04-28 | 2023-08-18 | 深圳市万臣科技有限公司 | Pipetting assembly |
| CN110297101A (en) * | 2019-07-30 | 2019-10-01 | 南京岚煜生物科技有限公司 | The method of the automatic sample machine and automatic sample of sample adding device and pipeline system detection |
| CN110488002A (en) * | 2019-08-30 | 2019-11-22 | 重庆康巨全弘生物科技有限公司 | A kind of device for immunochromatography convenient for adding liquid |
| CN110488002B (en) * | 2019-08-30 | 2022-06-21 | 重庆康巨全弘生物科技有限公司 | Immunochromatography device convenient to add liquid |
| CN111474360B (en) * | 2020-05-18 | 2023-10-10 | 四川新健康成生物股份有限公司 | Dry-type fluorescence immunoassay appearance |
| CN111474360A (en) * | 2020-05-18 | 2020-07-31 | 四川新健康成生物股份有限公司 | Dry-type fluorescence immunoassay appearance |
| WO2022068523A1 (en) * | 2020-09-29 | 2022-04-07 | 江苏百英吉生命科学技术有限公司 | Detection system for detecting biological fluid sample |
| CN112345746A (en) * | 2021-01-08 | 2021-02-09 | 南京澳林生物科技有限公司 | Modularized full-automatic biochemical analyzer and use method thereof |
| WO2022166051A1 (en) * | 2021-02-04 | 2022-08-11 | 南京宝沃生物科技有限公司 | Fully automatic wb incubation system |
| CN112793879A (en) * | 2021-04-13 | 2021-05-14 | 苏州长光华医生物医学工程有限公司 | Device for automatically puncturing cover |
| CN113203602A (en) * | 2021-05-24 | 2021-08-03 | 重庆医科大学附属第一医院 | Sampling device for medical examination |
| CN113341129B (en) * | 2021-06-10 | 2023-11-24 | 禾柏(南京)医学科技有限公司 | Fluorescence immunoassay device and control method |
| CN113341129A (en) * | 2021-06-10 | 2021-09-03 | 禾柏(南京)医学科技有限公司 | Fluorescence immunoassay device and control method |
| CN113376393A (en) * | 2021-07-09 | 2021-09-10 | 广州蓝勃生物科技有限公司 | Full-automatic immunoassay analyzer and detection method |
| CN116413460A (en) * | 2021-12-31 | 2023-07-11 | 力合科技（湖南）股份有限公司 | Automatic solution analysis device |
| CN117434280A (en) * | 2023-12-21 | 2024-01-23 | 广州誉康医药有限公司 | Reagent card selecting and puncturing system |
| CN117434280B (en) * | 2023-12-21 | 2024-02-23 | 广州誉康医药有限公司 | Reagent card selecting and puncturing system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106596989B (en) | 2019-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106596989A (en) | Full-automatic immunization analyzer and detection method | |
| US10338064B2 (en) | Fully-automatic immunofluorescence quantitative analysis apparatus and detection method | |
| CN105745546B (en) | With below can injection system automated diagnostic analyzer and correlation technique | |
| US5178834A (en) | Automatic immunoassay analyzer | |
| CN107656085B (en) | Blood detector | |
| CN106932601B (en) | A kind of Biochemical Analyzer and its detection method | |
| CN111751558A (en) | Full-automatic fluorescence immunoassay analyzer and sample detection method | |
| CN109633186A (en) | Full-automatic fluorescence immunity analyzer | |
| KR20160134542A (en) | Station for test device with integrated reaction and detection means | |
| CA1143261A (en) | Discrete type automated chemical analytic apparatus | |
| CN108663530A (en) | A kind of control method of immunoassay apparatus | |
| CN110045134A (en) | A kind of full automatic chemiluminescence immunoassay instrument and its application method | |
| CN105628947A (en) | Whole blood autoluminescence immunoassay point-of-care test instrument | |
| CN201434869Y (en) | Body-fluid leucorrhea dry-chemistry auto-analyzer | |
| CN106443034B (en) | Full-automatic immune quantitative analyzer | |
| KR102568429B1 (en) | Automatic In-vitro diagnostic apparatus | |
| CN211061566U (en) | Sample introduction and output device | |
| CN207114557U (en) | A kind of automatic lmunoassays analyzer | |
| CN113804906A (en) | Full-automatic fluorescent quantitative analyzer | |
| CN108414522A (en) | The device of all-in-one machine is detected for micro-fluidic chip and the more flux of NC films | |
| JP6549983B2 (en) | Sample rack transport device and automatic analysis system | |
| CN104730264B (en) | Detection liquid integrated information detecting device and method thereof based on detection card | |
| CN109283351B (en) | Full-automatic blood coagulation analyzer | |
| CN110220890A (en) | Vaginal fluid detector | |
| CN104714004B (en) | Biological detection card integrated information acquisition method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |