CN106932601A - A kind of Biochemical Analyzer and its detection method - Google Patents
A kind of Biochemical Analyzer and its detection method Download PDFInfo
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract
The application is related to a kind of Biochemical Analyzer and its detection method, including base（12）, in the base（12）Upper fixed sampling module（4）, incubating device（3）And detection means（6）, the incubating device（3）Including line slideway 305, incubation slot 310, the incubation slot 310 can be moved along the line slideway 305；Also include mobile device, detection components, the mobile device makes the chip cartridges in the incubation slot 310（11）Moved along the vertical direction of line slideway 305, can be by the detection components to chip cartridges（11）Detected.By carrying out the double detections of colorimetric and scattering turbidimetry, multiple projects of multiple projects that can quickly to same target or multiple object are detected the application.The application have single part, many targets, multichannel, full-automatic, flux it is higher, it is easy to use the features such as.
Description
Technical field
The application is related to a kind of Biochemical Analyzer and its detection method, and more particularly to one kind can simplify structure, quick inspection
A kind of Biochemical Analyzer and its detection method surveyed.
Background technology
Current existing many automatic clinical chemistry analyzers, mostly using disc type reaction tray, disc type sample disc and reagent
Dish structure, such as patent application of Publication No. CN104833812, are all using single using disc type reaction dish structure, kit
The many person-portion encapsulation of project；Analysis sample is typically all batch mode, i.e., the multiple samples that will be analyzed all are carried in sample
On disk, after setting corresponding program, sample of the analyzer automatically to being loaded carries out batch quantity analysis.Such Biochemical Analyzer
Structure, reagent encapsulation and sample analysis mode be especially suitable for the big of medium-and-large-sized hospital laboratory or third party testing agency
The analysis of sample size, for basic medical unit（Society's health, health clinics in towns and townships）, clinical department and big-and-middle-sized hospital Emergency call
It is just very improper.
Basic medical unit is few due to daily specimen amount, but detection project and many, such as liver function for common disease
Energy 8, renal function 5, blood fat 5 or 7,2, blood sugar.Due to being required for calibrating after biochemical reagents corkage and having certain
The reagent term of validity, also has many situations for not being finished just failure, so that basic hospital is difficult after often there is reagent
The detection of biochemical analysis is carried out.
Be not suitable for the situation that basic medical unit is used for current automatic clinical chemistry analyzer, develop based on micro-fluidic
The automatic clinical chemistry analyzer of chip and its supporting integrated chip, such as CN104833812, CN102580797 patent, reagent
Encapsulation and detection mode using many targets of single part, can necessarily meet the demand of basic hospital biochemistry detection, but the system and
Detection method has following defect：1st, the chip uses freeze-dried reagent, and reagent 1 (R1) and reagent 2 (R2) are put together, during reaction
Sample and R1 and R2 simultaneous reactions, because the detection for having many projects needs sample and R1 first to react, after reaction a period of time again
Plus R2 is reacted（Such as detection, the inspection of the glycosylated hemoglobin based on enzyme process of the homocysteine based on Enzymatic cycling
Survey）, so limit application of the instrument to detection project；2nd, instrument can only once measure a chip, each chip
Detection time 10 minutes or so, such detection flux very little, is only suitable for the basic medical unit of detection limit very little；3rd, chip knot
Structure is complicated, reagent needs to freeze, and causes the cost of reagent chip higher；4th, operator's quantitative addition sample and dilute by hand is needed
Liquid is released, the operation level of operator directly affects the accuracy of measurement result.
Existing automatic clinical chemistry analyzer, its Cleaning Principle can be divided into colorimetric and immunoturbidimetry two ways, colorimetric
Cleaning Principle is that, based on molecule absorption, the Cleaning Principle of immunoturbidimetry is the folding based on the compound after antigen-antibody reaction to light
Penetrate and scatter.Immunoturbidimetry can be divided into that transmittance is turbid and scattering turbidimetry again：Transmittance is turbid easy to operate, but sensitivity and precision
Degree is not ideal enough, and required antiserum amount is big, and the cycle of detection is more long；Scattering turbidimetry sensitivity, precision are higher, inspection
Survey quick.
For filling sample, reagent, four troublesome operations of washing and interpretation chromogenic reaction result in detection, however, each
Stage has cumbersome step in itself, meanwhile, operate the structure of each stage etch also very complicated, cause whole Biochemical Analyzer
Troublesome poeration, high cost, when testing result is judged, typically carries out result judgement by colorimetric or than turbid mode, its
It is middle more turbid using transmittance than turbid mode, it is few to accomplish in an equipment while colorimetric and scattering turbidimetry inspection can be carried out
Survey, reduce the adaptability of equipment, meanwhile, existing equipment must all carry out large batch of sample judgement, it is impossible to small lot and
It is large batch of all to be detected, it is impossible to realize " immediate delivery ", cause existing detecting instrument to meet the effect of quick detection
Really.
To solve the problems, such as our the difficulty of getting medical service and the high cost of getting medical treatment, country just actively pushes forward to be classified diagnosis and treatment policy, common disease now
Tried one's best with chronic disease medical in basic medical unit.In order to solve variety of problems present in prior art, therefore the application is proposed,
Meet the basic medical unit need higher, easy to use to the single part of biochemical analysis, many targets, multichannel, full-automatic, flux
Ask, detection can be made to realize " immediate delivery ".
The content of the invention
To solve above-mentioned technical problem：A kind of Biochemical Analyzer, including base（12）, in the base（12）Upper fixation takes
Original mold group（4）, incubating device（3）And detection means（6）, the incubating device（3）Including line slideway 305, incubation slot 310,
The incubation slot 310 can be moved along the line slideway 305；Also include mobile device, detection components, the mobile device makes institute
State the chip cartridges in incubation slot 310（11）Moved along the vertical direction of line slideway 305, by the detection components to chip cartridges
（11）Detected.
Described Biochemical Analyzer, wherein, one or at least two parallel grooves are provided with the incubation slot 310.
Described Biochemical Analyzer, wherein, the mobile device includes the driving lever 609 being arranged in detection components or shakes up
Module（5）On at least one eccentric driving lever 509.
Described Biochemical Analyzer, wherein, the mobile device includes being arranged on incubating device（3）On pushing meanss.
Described Biochemical Analyzer, wherein, also including shaking up module（5）, it is described to shake up module（5）With the detection means
（6）Positioned at the same side of the line slideway 305.
Described Biochemical Analyzer, wherein, also including shaking up module（5）, it is described to shake up module（5）Including eccentric driving lever
509th, shake up groove 511, shake up motor 508, the eccentric driving lever 509 makes the chip cartridges in the incubation slot 310（11）Along straight line
The vertical direction movement of guide rail 305, move to it is described shake up groove 511, carried out to chip cartridges by the motor 508 that shakes up
（11）Shaken up.
Described Biochemical Analyzer, wherein, it is described to shake up module（5）Also include moving horizontally motor 501, screw mandrel 502, near
End sensor 503, guide rail 504, slide block assembly 505, distal sensor 506, sensing chip 507, eccentric driving lever position sensor
510th, support 512；Positioned at one end of the screw mandrel 502, the distal end passes motor 501, the proximal sensor 503 of moving horizontally
Sensor 506, sensing chip 507 be located at the screw mandrel 502 the other end, the guide rail 504 on the screw mandrel 502, the cunning
Block assembly 505 is located on the guide rail 504；The eccentric driving lever position sensor 510 is used to detect the position of eccentric driving lever 509
Information, the proximal sensor 503, distal sensor 506 are used to sense sensing chip 507 to determine chip cartridges（11）Whether dial in
Groove 511 is shaken up to described, the support 512 is used to shake up module by described（5）It is fixed on the base（12）On.
Described Biochemical Analyzer, wherein, the detection means（6）It is double detection modules, including colorimetric detection component 610
With scattering turbidimetry detection components 611.
Described Biochemical Analyzer, wherein, the colorimetric detection component 610 and scattering turbidimetry detection components 611 are integrated in
In one module, colorimetric, scattering turbidimetry detection can be simultaneously carried out.
Described Biochemical Analyzer, wherein, the detection means（6）Also include motor 601, screw mandrel 602, nut sleeve, near
End sensor 604, guide rail 605, slide body 606, detect tank 607, distal sensor 608, support 612；It is the motor 601, near
End sensor 604 is located at one end of the screw mandrel 602, and the distal sensor 608 is located at the other end of the screw mandrel 602；Institute
Guide rail 605 is stated positioned at the downside of the screw mandrel 602, the slide body 606 is embedded among the screw mandrel 602 and the guide rail 605,
Moved by the rotational band movable slider body 606 of screw mandrel 602, chip cartridges are stirred by the driving lever 609（11）To the detect tank
In 607；The nut sleeve is enclosed within the screw mandrel 602, and the support 612 is used for the detection means（5）It is fixed on described
Base（12）On.
Described Biochemical Analyzer, wherein, the bottom of the incubation slot 310 down-set temperature transducer 309, electronics successively
Module 308, thermal insulation board 307, radiator 306, the temperature transducer 309 are used for the reaction temperature of detection chip, the electronics
Module 308 is used to carry out temperature control, and the thermal insulation board 307, radiator 306 are used for heat-insulated, radiating, can accurately control described incubating
Educate the temperature of groove 310.
Described Biochemical Analyzer, wherein, the incubating device（3）Be movable incubating device, also including insulation cover 301,
Motor 302, synchronous belt 303, sliding block, support 311, position sensor 312；The insulation cover 301 is used to cover in the incubation
On groove 310, it is incubated；The motor 302 is located at the side of one end of line slideway 305, and is fixed on the support 311
On, the sliding block on the synchronous belt 303 and line slideway 305 is driven, so that incubation slot 310 is moved along the straight line of line slideway 305
Dynamic, the position sensor 312 is arranged on the other end of the line slideway 305, the position for sensing the incubation slot 310
Information.
Described Biochemical Analyzer, wherein, also including sampling device（1）, the sampling device（1）Including rack for test tube 101,
Bearing 103, initial level sensor 104, motor 105, terminal inductor 107, service sink 108 and it is positioned over the rack for test tube
Multiple samples 102 in 101, the bearing 103 places the linear platform of plane of the rack for test tube 101, in linear platform
Entry position sets initial sensor 104, sets baffle plate in the end of linear platform, and set terminal sensing in the lower end of baffle plate
Device 107, the motor 105 is arranged at the side of the linear platform, and its connection is simultaneously acted, the gear 106 with moving gear 106
The bottom of the linear platform is arranged at, gear 106 is intermeshed with the tooth bar of rack for test tube bottom.
Described Biochemical Analyzer, wherein, also including chip cartridges conveying device（2）, the chip cartridges conveying device（2）Bag
Include support 201, motor 202, screw mandrel 203, screw mandrel mother set, proximal sensor 205, feeding detection sensor 206, code reader 207,
Sensing chip 208, distal sensor 209, charging sliding block 210；The motor 202, the proximal sensor 205 are arranged at the silk
One end of bar 203, the proximal sensor 205 is located at the side of screw mandrel 203；The distal sensor 209, the code reader
The side of 207 other ends for being located at the screw mandrel 203, the code reader 207 is used for the information of the chip cartridges for reading conveying；It is described
Feeding detection sensor 206 is located at the upper end of the screw mandrel 203, and near the motor 202.
Described Biochemical Analyzer, wherein, also including sampling assemble（4）, the sampling assemble（4）Including portal frame 412,
Sampling probe 411, lifting action part, horizontal balance part, the horizontal balance part are moved before and after driving the sampling probe 411
Dynamic, the lifting action part drives the lifting moving of sampling probe 411 to be sampled, and the horizontal balance part is located at described
On the cross bar of portal frame 412.
Described Biochemical Analyzer, wherein, the lifting action part includes lifting motor 405, lifting synchronous belt
406th, elevation sensor 407, lifting slider 408；The horizontal balance part includes level sensor 401, moves horizontally motor
402nd, horizontal synchronization belt 403, horizontal guide rail 404, cross sliding clock 410；The level sensor 401, move horizontally motor 402
The side of the one end of the horizontal guide rail 404 is arranged on, the horizontal synchronization belt 403 is arranged under the horizontal guide rail 404
End；The cross sliding clock 410 drives the lifting action component level to move, and it is dynamic that the lifting motor 405 is located at the lifting
Make the bottom side of part, the lifting synchronous belt 406 is driven, to drive the lifting slider 408 to carry out lifting action, institute
Elevation sensor 407 is stated positioned at the side of the lifting synchronous belt 406 of the lifting action section upper；In the portal frame
412 montant bottom sets code reader 517.
Described Biochemical Analyzer, wherein, also including device for discharging（7）, the device for discharging（7）Including bearing 701, electricity
Machine 702, ball screw 703, ball nut set, discharge arm 705, near-end inductor 706, sensing chip 707, distal end inductor 708,
Guide plate 709, the ball screw 703 is driven the discharge arm 705, and the discharge arm 705 promotes spent reagent to the guiding
In plate 709, the position of the discharge arm 705 is sensed by the near-end inductor 706, sensing chip 707, distal end inductor 708
Information, the sensing chip 707 is arranged on the discharge arm 705, and both holding positions are consistent.
Described Biochemical Analyzer, wherein, also including assembly of the plunger pump（9）；The assembly of the plunger pump（9）Including bearing
901st, motor 902, plunger displacement pump 903, pump inlet 904, pump discharge 905, magnetic valve SV2906；The bearing 901 includes mutually hanging down
Straight bottom plate and vertical plate, the bottom plate are used for the assembly of the plunger pump（9）It is fixed on the base（12）On, it is described perpendicular
Straight panel is used to fix the motor 902, plunger displacement pump 903, pump inlet 904, pump discharge 905, magnetic valve successively from bottom to up
SV2906。
Described Biochemical Analyzer, wherein, also including bellows pumping element（10）；The bellows pumping element（10）Including bearing
1001st, barrier film waste drains pump 1002, barrier film liquid feeding pump 1003, magnetic valve 1004, magnetic valve SV11005, the barrier film waste drains pump
1002nd, barrier film liquid feeding pump 1003 is set from bottom to top, and the magnetic valve 1004, magnetic valve SV11005 be arranged in parallel, positioned at described
On barrier film liquid feeding pump 1003.
A kind of detection method of Biochemical Analyzer, comprises the following steps：
（1）By chip cartridges（11）It is fixed on incubating device（3）In be incubated；
（2）Incubating device（3）Edge is moved straightly to sampling module（4）Downside, addition sample to chip cartridges（11）In；
（3）Mobile device makes the incubating device（3）In chip cartridges（11）Moved to along the vertical direction of line slideway and shaken up
Module（5）In, carry out shaking up operation；
（4）After the completion of shaking up, the incubating device is moved to（3）In, and the movement incubating device（3）Incubation slot 311 arrive
Detecting position；
（5）Detection means（6）The movement incubating device（3）In completed to shake up the chip cartridges of operation（11）Detected.
Described detection method, wherein, the step（1）Including by chip cartridges conveying device（2）By chip cartridges（11）
It is transported to the incubating device（3）It is fixed, or manually directly by chip cartridges（11）It is placed into the incubating device
（3）It is fixed.
Described detection method, wherein, the step（2）Including incubating device（3）Moved linearly along line slideway or so
To sampling module（4）Downside, samples module（4）Detect accordingly to chip cartridges（11）Afterwards, sampling probe to sampling device is moved（1）
In sample in be sampled, samples taken is then added to chip cartridges（11）In.
Described detection method, wherein, the step（3）Module is shaken up including described（5）The chip of sample will have been added
Box（11）From the incubating device（3）In dialled along the vertical direction with line slideway or so rectilinear movement by eccentric driving lever 509
Go out, the movement chip cartridges（11）To shaking up module（5）In shake up groove 511, when detecting the chip cartridges（11）Into
To after described shaking up in groove 511, startup shakes up motor 508 and is shaken up.
Described detection method, wherein, the number of times for shaking up operation matches with the total quantity of required reaction reagent.
Described detection method, wherein, the step（4）Comprise the following steps including shaking up completion：
1）, when only a kind of reagent and example reaction, then once shaken up operation；
2）, when need two kinds of reagents and example reaction when, then shaken up operation twice, specifically include following steps：
2-1）, first sample is added in the first reagent, carry out shaking up operation for the first time, temperature is then controlled in incubation slot
Reacted；2-2）, second reagent be added to step 2-1）In reagent after the completion of reaction, then will be shaken for the second time
Even operation, controls temperature to be reacted after the completion of shaking up；
Described detection method, wherein, the step（4）After the completion of shaking up, by eccentric driving lever 509 by chip cartridges（11）
Pull back to the incubating device（3）Incubation slot 311 in, the electronic module 308 for starting the downside of incubation slot 311 enters trip temperature control
System, and be thermally shielded by thermal insulation board 307, radiator 306, radiated with accurate regulating and controlling temperature, and along the incubating device（3）On
Line slideway move the incubation slot 311 and arrive detection means（6）Side；
Described detection method, wherein, the step（5）Including detection means（6）The incubating device is transferred to by driving lever 609
（3）Incubation slot 311 in completed to shake up the chip cartridges of operation（11）, the movement chip cartridges（11）To detection components, carry out
Colorimetric or scattering turbidimetry are detected, and detection information is fed back, and are transferred to signal transacting and display device.
Described detection method, wherein, after being additionally included in completion detection, the chip cartridges that will be detected（11）Carry out discharging.
The application have single part, many targets, multichannel, full-automatic, flux it is higher, it is easy to use the features such as.The application
Incubating device is designed as linear structure, relative to the disc structure of prior art, the volume of whole equipment is substantially reduced；Can
Chip cartridges are automatically added to either manually or by sample-adding component, with two kinds of detection modes of colorimetric and scattering turbidimetry, quick and inspection
High precision is surveyed, the use adaptedness of equipment is improve；Chip cartridges are taken out and are individually shaken up and is detected, reduce shake up and
Light detects the influence to other chips, improves sensitivity and the precision of testing result；The Biochemical Analyzer of the application is significantly
Overall structure is reduced, cost has been saved, the detection range of whole equipment is improve, contributes to all kinds of hospitals, scientific research personnel etc.
Carry out biochemical analysis.
Brief description of the drawings
Fig. 1 is the application Biochemical Analyzer general structure schematic diagram.
Fig. 2 is the application sampling device structural representation.
Fig. 3 is the application chip cartridges transport conveyor constructions schematic diagram.
Fig. 4 is the movable incubating device structural representation of the application.
Fig. 5 is that the application samples module structural representation.
Fig. 6 shakes up modular structure schematic diagram for the application.
Fig. 7 is the double detection modular structure schematic diagrames of the application.
Fig. 8 is the application device for discharging structural representation.
Fig. 9 is the application assembly of the plunger pump structural representation.
Figure 10 is the application bellows pumping element structural representation.
Specific embodiment
The application is described in further detail below in conjunction with the accompanying drawings, it is necessary to it is pointed out here that, implement in detail below
Mode is served only for being further detailed the application, it is impossible to be interpreted as the limitation to the application protection domain, the field
Technical staff can make some nonessential modifications and adaptations to the application according to above-mentioned application content.
Embodiment one：
It is as shown in Figure 1 the application Biochemical Analyzer general structure schematic diagram.Shown Biochemical Analyzer includes sampling device（1）、
Chip cartridges conveying device（2）, movable incubating device（3）, sampling module（4）, shake up module（5）, double detection modules（6）, discharging
Device（7）, waste material box（8）, assembly of the plunger pump（9）, bellows pumping element（10）, chip cartridges（11）, base（12）.Including base
（12）, in the base（12）Upper fixed sampling module（4）, incubating device（3）And detection means（6）, the incubating device（3）
Including line slideway 305, incubation slot 310, the incubation slot 310 can be moved along the line slideway 305；Also include mobile dress
Put, detection components, the mobile device makes the chip cartridges in the incubation slot 310（11）Along the vertical direction of line slideway 305
It is mobile, by the detection components to chip cartridges（11）Detected.One or at least two are provided with the incubation slot 310
Parallel groove.
The mobile device includes the driving lever 609 being arranged in detection components or shakes up module（5）On eccentric driving lever 509
At least one, chip cartridges are made by the driving lever 609 in detection components（11）Can be from the incubation slot 310 and detection components, such as
Moved linearly repeatedly between double detection modules.
The oscillating uniform device can be using such as detection module identical mobile device, by chip cartridges（11）Along line slideway
Vertical direction is moved back and forth.
It is described to shake up module（5）With the detection means（6）Positioned at the side of the line slideway 305.
It is illustrated in figure 2 the application sampling device structural representation.The sampling device（1）Including rack for test tube 101, bearing
103rd, initial level sensor 104, motor 105, terminal inductor 107, service sink 108 and it is positioned in the rack for test tube 101
Multiple samples 102, the bearing 103 places the linear platform of plane of the rack for test tube 101, in the entrance position of linear platform
Initial sensor 104 is installed, baffle plate is set in the end of linear platform, and terminal inductor 107 is set in the lower end of baffle plate,
The motor 105 is arranged at the side of the linear platform, and its connection is simultaneously acted with moving gear 106, and the gear 106 is arranged at
The bottom of the linear platform, gear 106 is intermeshed with the tooth bar of rack for test tube bottom.
It is illustrated in figure 3 the application chip cartridges transport conveyor constructions schematic diagram.The chip cartridges conveying device（2）Including branch
Frame 201, motor 202, screw mandrel 203, screw mandrel mother set (not identified in figure), proximal sensor 205, feeding detection sensor 206, reading
Code device 207, sensing chip 208, distal sensor 209, charging sliding block 210；The motor 202, the proximal sensor 205 are set
In one end of the screw mandrel 203, the proximal sensor 205 is located at the side of screw mandrel 203；It is the distal sensor 209, described
Code reader 207 is located at the side of the other end of the screw mandrel 203, and the code reader 207 is used for the letter of the chip cartridges for reading conveying
Breath；The feeding detection sensor 206 is located at the upper end of the screw mandrel 203, and near the motor 202.
It is illustrated in figure 4 the movable incubating device structural representation of the application.The bottom of the incubation slot 310 is down-set successively
Temperature transducer 309, electronic module 308, thermal insulation board 307, radiator 306, the temperature transducer 309 are used for detection chip
Reaction temperature, the electronic module 308 is used to carry out temperature control, and the thermal insulation board 307, radiator 306 are used for heat-insulated, scattered
Heat, can accurately control the temperature of the incubation slot 310.
Described Biochemical Analyzer, wherein, the incubating device（3）Be movable incubating device, also including insulation cover 301,
Motor 302, synchronous belt 303, sliding block（Do not identified in figure）, support 311, position sensor 312；The insulation cover 301 is used for
Cover on the incubation slot 310, be incubated；The motor 302 is located at the side of one end of line slideway 305, and fixed
On the support 311, the sliding block on the synchronous belt 303 and line slideway 305 is driven, so that incubation slot 310 is along straight line
Guide rail 305 moves linearly, and the position sensor 312 is arranged on the other end of the line slideway 305, for sensing described incubating
Educate the positional information of groove 310.
It is illustrated in figure 5 the application sampling module structural representation, the sampling assemble（4）Including portal frame 412, sampling
Pin 411, lifting action part, horizontal balance part, the horizontal balance part drive the sampling probe 411 to move forward and backward, institute
Stating lifting action part drives the lifting moving of sampling probe 411 to be sampled, and the horizontal balance part is located at described gantry
On the cross bar of frame 412.
Described Biochemical Analyzer, wherein, the lifting action part includes lifting motor 405, lifting synchronous belt
406th, elevation sensor 407, lifting slider 408；The horizontal balance part includes level sensor 401, moves horizontally motor
402nd, horizontal synchronization belt 403, horizontal guide rail 404, cross sliding clock 410；The level sensor 401, move horizontally motor 402
The side of the one end of the horizontal guide rail 404 is arranged on, the horizontal synchronization belt 403 is arranged under the horizontal guide rail 404
End；The cross sliding clock 410 drives the lifting action component level to move, and it is dynamic that the lifting motor 405 is located at the lifting
Make the bottom side of part, the lifting synchronous belt 406 is driven, to drive the lifting slider 408 to carry out lifting action, institute
Elevation sensor 407 is stated positioned at the side of the lifting synchronous belt 406 of the lifting action section upper；In the portal frame
412 montant bottom sets code reader 517, and the code reader 517 is used to read sampling device（1）It is many in rack for test tube 101
The information of individual sample 102.
It is illustrated in figure 6 the application and shakes up modular structure schematic diagram, it is described to shake up module（5）Including eccentric driving lever 509, shake
Even groove 511, motor 508 is shaken up, the eccentric driving lever 509 makes the chip cartridges in the incubation slot 310（11）Along line slideway 305
Vertical direction movement, move to it is described shake up groove 511, carried out to chip cartridges by the motor 508 that shakes up（11）Carry out
Shake up.
Described Biochemical Analyzer, wherein, it is described to shake up module（5）Also include moving horizontally motor 501, screw mandrel 502, near
End sensor 503, guide rail 504, slide block assembly 505, distal sensor 506, sensing chip 507, eccentric driving lever position sensor
510th, support 512；Positioned at one end of the screw mandrel 502, the distal end passes motor 501, the proximal sensor 503 of moving horizontally
Sensor 506, sensing chip 507 be located at the screw mandrel 502 the other end, the guide rail 504 on the screw mandrel 502, the cunning
Block assembly 505 is located on the guide rail 504；The eccentric driving lever position sensor 510 is used to detect the position of eccentric driving lever 509
Information, the proximal sensor 503, distal sensor 506 are used to sense sensing chip 507 to determine chip cartridges（11）Whether dial in
Groove 511 is shaken up to described, the support 512 is used to shake up module by described（5）It is fixed on the base（12）On.
It is illustrated in figure 7 the double detection modular structure schematic diagrames of the application, the detection means（6）It is double detection modules, bag
Include colorimetric detection component 610 and scattering turbidimetry detection components 611.
Described Biochemical Analyzer, wherein, the colorimetric detection component 610 and scattering turbidimetry detection components 611 are integrated in
In one module, colorimetric, scattering turbidimetry detection can be simultaneously carried out.
Described Biochemical Analyzer, wherein, the detection means（6）Also include motor 601, screw mandrel 602, nut sleeve（Figure
In do not identify）, proximal sensor 604, guide rail 605, slide body 606, detect tank 607, distal sensor 608, support 612；Institute
Motor 601, proximal sensor 604 are stated positioned at one end of the screw mandrel 602, the distal sensor 608 is located at the screw mandrel 602
The other end；The guide rail 605 is located at the downside of the screw mandrel 602, and the slide body 606 is embedded in the screw mandrel 602 and described
Among guide rail 605, moved by the rotational band movable slider body 606 of screw mandrel 602, chip cartridges are stirred by the driving lever 609（11）
To in the detect tank 607；The nut sleeve（Do not identified in figure）It is enclosed within the screw mandrel 602, the support 612 is used for institute
State detection means（5）It is fixed on the base（12）On.
It is illustrated in figure 8 the application device for discharging structural representation.The device for discharging（7）Including bearing 701, motor
702nd, ball screw 703, ball nut set（Do not identified in figure）, discharge arm 705, near-end inductor 706, sensing chip 707, distal end
Inductor 708, guide plate 709, the ball screw 703 are driven the discharge arm 705, and the discharge arm 705 promotes spent reagent
To in the guide plate 709, the discharge arm is sensed by the near-end inductor 706, sensing chip 707, distal end inductor 708
705 positional information, the sensing chip 707 is arranged on the discharge arm 705, and both holding positions are consistent.
It is illustrated in figure 9 the application assembly of the plunger pump structural representation, the assembly of the plunger pump（9）Including bearing 901, electricity
Machine 902, plunger displacement pump 903, pump inlet 904, pump discharge 905, magnetic valve SV2906；The bearing 901 includes being mutually perpendicular to bottom
Plate and vertical plate, the bottom plate are used for the assembly of the plunger pump（9）It is fixed on the base（12）On, the vertical plate is used
In from bottom to up successively fix the motor 902, plunger displacement pump 903, pump inlet 904, pump discharge 905, magnetic valve SV2906.
It is as shown in Figure 10 the application bellows pumping element structural representation, the bellows pumping element（10）Including bearing
1001st, barrier film waste drains pump 1002, barrier film liquid feeding pump 1003, magnetic valve 1004, magnetic valve SV11005, the barrier film waste drains pump
1002nd, barrier film liquid feeding pump 1003 is set from bottom to top, and the magnetic valve 1004, magnetic valve SV11005 be arranged in parallel, positioned at described
On barrier film liquid feeding pump 1003.
The detection method of the Biochemical Analyzer of the application, comprises the following steps：
（1）By chip cartridges（11）It is fixed on incubating device（3）In be incubated；
（2）Incubating device（3）Edge is moved straightly to sampling module（4）Downside, addition sample to chip cartridges（11）In；
（3）Mobile device makes the incubating device（3）In chip cartridges（11）Moved to along the vertical direction of line slideway and shaken up
Module（5）In, carry out shaking up operation；
（4）After the completion of shaking up, the incubating device is moved to（3）In, and the movement incubating device（3）Incubation slot 311 arrive
Detecting position；
（5）Detection means（6）The movement incubating device（3）In completed to shake up, be incubated the chip cartridges of operation（11）Examined
Survey.
Described detection method, wherein, the step（1）Including by chip cartridges conveying device（2）By chip cartridges（11）
It is transported to the incubating device（3）It is fixed, or manually directly by chip cartridges（11）It is placed into the incubating device
（3）It is fixed.
Described detection method, wherein, the step（2）Including incubating device（3）Moved linearly along line slideway or so
To sampling module（4）Downside, samples module（4）Detect accordingly to chip cartridges（11）Afterwards, sampling probe to sampling device is moved（1）
In sample in be sampled, samples taken is then added to chip cartridges（11）In.
Described detection method, wherein, the step（3）Module is shaken up including described（5）The chip of sample will have been added
Box（11）From the incubating device（3）In dialled along the vertical direction with line slideway or so rectilinear movement by eccentric driving lever 509
Go out, the movement chip cartridges（11）To shaking up module（5）In shake up groove 511, when detecting the chip cartridges（11）Into
To after described shaking up in groove 511, startup shakes up motor 508 and is shaken up.
Described detection method, wherein, the number of times for shaking up operation matches with the total quantity of required reaction reagent.
Described detection method, wherein, the step（4）Comprise the following steps including shaking up completion：
1）, when only a kind of reagent and example reaction, then once shaken up operation；
2）, when need two kinds of reagents and example reaction when, then shaken up operation twice, specifically include following steps：
2-1）, first sample is added in the first reagent, carry out shaking up operation for the first time, temperature is then controlled in incubation slot
Reacted；2-2）, second reagent be added to step 2-1）In reagent after the completion of reaction, then will be shaken for the second time
Even operation, controls temperature to be reacted after the completion of shaking up；
Described detection method, wherein, the step（4）After the completion of shaking up, by eccentric driving lever 509 by chip cartridges（11）
Pull back to the incubating device（3）Incubation slot 311 in, the electronic module 308 for starting the downside of incubation slot 311 enters trip temperature control
System, and be thermally shielded by thermal insulation board 307, radiator 306, radiated with accurate regulating and controlling temperature, and along the incubating device（3）On
Line slideway move the incubation slot 311 and arrive detection means（6）Side；
Described detection method, wherein, the step（5）Including detection means（6）The incubating device is transferred to by driving lever 609
（3）Incubation slot 311 in completed to shake up the chip cartridges of operation（11）, the movement chip cartridges（11）To detection components, carry out
Colorimetric or scattering turbidimetry are detected, and detection information is fed back, and are transferred to control device.
Described detection method, wherein, after being additionally included in completion detection, the chip cartridges that will be detected（11）Carry out discharging.
Embodiment two：
The Biochemical Analyzer includes sampling device（1）, chip cartridges conveying device（2）, movable incubating device（3）, sampling module
（4）, shake up module（5）, double detection modules（6）, device for discharging（7）, waste material box（8）, assembly of the plunger pump（9）, bellows pumping element
（10）, chip cartridges（11）, base（12）.Including base（12）, in the base（12）Upper fixed sampling module（4）, be incubated dress
Put（3）And detection means（6）, the incubating device（3）Including line slideway 305, incubation slot 310, the incubation slot 310 can edge
The line slideway 305 is moved；Also include mobile device, detection components, the mobile device makes the core in the incubation slot 310
Film magazine（11）Moved along the vertical direction of line slideway 305, by the detection components to chip cartridges（11）Detected.It is described
One or at least two parallel grooves are provided with incubation slot 310.
The mobile device includes being arranged on incubating device（3）On pushing meanss, make chip cartridges by pushing meanss
（11）Can repeatedly be moved linearly between such as double detection modules from the incubation slot 310 and detection components.Other can also be used
Moving structure, as long as can realize that chip cartridges move linearly in incubation slot 310 and detection components.
The module that shakes up can be using such as detection module identical mobile device, by chip cartridges（11）Along line slideway
Vertical direction is moved back and forth.
Other structures and operation are identical with embodiment one.
The application have single part, many targets, multichannel, full-automatic, flux it is higher, it is easy to use the features such as.The application
Incubating device is designed as linear structure, relative to the disc structure of prior art, the volume of whole equipment is substantially reduced；Can
Chip cartridges are automatically added to either manually or by sample-adding component, with two kinds of detection modes of colorimetric and scattering turbidimetry, quick and inspection
High precision is surveyed, the use adaptedness of equipment is improve；Chip cartridges are taken out and are individually shaken up and is detected, reduce shake up and
Light detects the influence to other chips, improves sensitivity and the precision of testing result；The Biochemical Analyzer of the application is significantly
Overall structure is reduced, cost has been saved, the detection range of whole equipment is improve, contributes to all kinds of hospitals, scientific research personnel etc.
Carry out biochemical analysis.
Claims (28)
1. a kind of Biochemical Analyzer, including base（12）, it is characterised in that：In the base（12）Upper fixed sampling module（4）、
Incubating device（3）And detection means（6）, the incubating device（3）Including line slideway 305, incubation slot 310, the incubation slot
310 can move along the line slideway 305；Also include mobile device, detection components, the mobile device makes the incubation slot
Chip cartridges in 310（11）Moved along the vertical direction of line slideway 305, can be by the detection components to the chip cartridges
（11）Detected.
2. Biochemical Analyzer as claimed in claim 1, it is characterised in that：One or at least is provided with the incubation slot 310
Two parallel grooves.
3. Biochemical Analyzer as claimed in claim 1, it is characterised in that：The mobile device includes being arranged on the detection group
Driving lever 609 on part shakes up module（5）On at least one eccentric driving lever 509.
4. Biochemical Analyzer as claimed in claim 1, it is characterised in that：The mobile device includes that being arranged on described incubation fills
Put（3）On pushing meanss.
5. Biochemical Analyzer as claimed in claim 1, it is characterised in that：Also include shaking up module（5）, it is described to shake up module
（5）With the detection means（6）Positioned at the side of the line slideway 305.
6. Biochemical Analyzer as claimed in claim 1, it is characterised in that：Also include shaking up module（5）, it is described to shake up module
（5）Including eccentric driving lever 509, shake up groove 511, shake up motor 508, the eccentric driving lever 509 will make in the incubation slot 310
Chip cartridges（11）Moved along the vertical direction of line slideway 305, move to it is described shake up groove 511, shake up motor by described
508 are carried out to chip cartridges（11）Shaken up.
7. Biochemical Analyzer as claimed in claim 6, it is characterised in that：It is described to shake up module（5）Also include moving horizontally electricity
Machine 501, screw mandrel 502, proximal sensor 503, guide rail 504, slide block assembly 505, distal sensor 506, sensing chip 507, bias
Driving lever position sensor 510, support 512；Motor 501, the proximal sensor 503 of moving horizontally is positioned at the screw mandrel 502
One end, the distal sensor 506, sensing chip 507 are located at the other end of the screw mandrel 502, and the guide rail 504 is in the screw mandrel
On 502, the slide block assembly 505 is located on the guide rail 504；The eccentric driving lever position sensor 510 is used to detect partially
The positional information of heart driving lever 509, the proximal sensor 503, distal sensor 506 are used to sense sensing chip 507 to determine core
Film magazine（11）Whether dial in it is described shake up groove 511, the support 512 is used to shake up module by described（5）It is fixed on described
Base（12）On.
8. Biochemical Analyzer as claimed in claim 3, it is characterised in that：The detection means（6）It is double detection modules, including
Colorimetric detection component 610 and scattering turbidimetry detection components 611.
9. Biochemical Analyzer as claimed in claim 8, it is characterised in that：The colorimetric detection component 610 and scattering turbidimetry are examined
Survey component 611 to be integrated in a module, can simultaneously carry out colorimetric, scattering turbidimetry detection.
10. Biochemical Analyzer as claimed in claim 8, it is characterised in that：The detection means（6）Also include motor 601, silk
Bar 602, nut sleeve, proximal sensor 604, guide rail 605, slide body 606, detect tank 607, distal sensor 608, support 612；
The motor 601, proximal sensor 604 are located at one end of the screw mandrel 602, and the distal sensor 608 is located at the screw mandrel
602 other end；The guide rail 605 is located at the downside of the screw mandrel 602, and the slide body 606 is embedded in the screw mandrel 602 and institute
State among guide rail 605, moved by the rotational band movable slider body 606 of screw mandrel 602, chip cartridges are stirred by the driving lever 609
（11）To in the detect tank 607；The nut sleeve is enclosed within the screw mandrel 602, and the support 612 is used to fill the detection
Put（5）It is fixed on the base（12）On.
11. Biochemical Analyzers as claimed in claim 1, it is characterised in that：The down-set survey successively of the bottom of the incubation slot 310
Temperature sensor 309, electronic module 308, thermal insulation board 307, radiator 306, the temperature transducer 309 are used for the anti-of detection chip
Temperature is answered, the electronic module 308 is used to carry out temperature control, and the thermal insulation board 307, radiator 306 are used for heat-insulated, radiating,
The temperature of the incubation slot 310 can accurately be controlled.
12. Biochemical Analyzers as claimed in claim 11, it is characterised in that：The incubating device（3）It is movable incubating device,
Also include insulation cover 301, motor 302, synchronous belt 303, sliding block, support 311, position sensor 312；The insulation cover 301
For covering on the incubation slot 310, it is incubated；The motor 302 is located at the side of one end of line slideway 305, and
It is fixed on the support 311, the sliding block on the synchronous belt 303 and line slideway 305 is driven, so that the edge of incubation slot 310
Line slideway 305 moves linearly, and the position sensor 312 is arranged on the other end of the line slideway 305, for sensing
State the positional information of incubation slot 310.
13. Biochemical Analyzers as claimed in claim 1, it is characterised in that：Also include sampling device（1）, the sampling device
（1）Including rack for test tube 101, bearing 103, initial level sensor 104, motor 105, terminal inductor 107, service sink 108 and
The multiple samples 102 in the rack for test tube 101 are positioned over, the plane that the bearing 103 places the rack for test tube 101 is linearly put down
Platform, initial sensor 104 is set in the entry position of linear platform, and baffle plate is set in the end of linear platform, and in baffle plate
Lower end sets terminal inductor 107, and the motor 105 is arranged at the side of the linear platform, and its connection is simultaneously with moving gear 106
Action, the gear 106 is arranged at the bottom of the linear platform, and gear 106 is intermeshed with the tooth bar of rack for test tube bottom.
14. Biochemical Analyzers as claimed in claim 1, it is characterised in that：Also include chip cartridges conveying device（2）, the core
Film magazine conveying device（2）Passed including support 201, motor 202, screw mandrel 203, screw mandrel mother set, the detection of proximal sensor 205, feeding
Sensor 206, code reader 207, sensing chip 208, distal sensor 209, charging sliding block 210；The motor 202, the near-end are passed
Sensor 205 is arranged at one end of the screw mandrel 203, and the proximal sensor 205 is located at the side of screw mandrel 203；The distal end passes
Sensor 209, the code reader 207 are located at the side of the other end of the screw mandrel 203, and the code reader 207 is used to read conveying
Chip cartridges information；The feeding detection sensor 206 is located at the upper end of the screw mandrel 203, and near the motor 202.
15. Biochemical Analyzers as claimed in claim 1, it is characterised in that：Also include sampling assemble（4）, the sampling assemble
（4）Including portal frame 412, sampling probe 411, lifting action part, horizontal balance part, the horizontal balance part drives described
Sampling probe 411 is moved forward and backward, and the lifting action part drives the lifting moving of sampling probe 411 to be sampled, the level
Action component is located on the cross bar of the portal frame 412.
16. Biochemical Analyzers as claimed in claim 15, it is characterised in that：The lifting action part includes lifting motor
405th, lifting synchronous belt 406, elevation sensor 407, lifting slider 408；The horizontal balance part includes level sensor
401st, motor 402, horizontal synchronization belt 403, horizontal guide rail 404, cross sliding clock 410 are moved horizontally；The level sensor
401st, the side that motor 402 is arranged on the one end of the horizontal guide rail 404 is moved horizontally, the horizontal synchronization belt 403 is arranged on
The lower end of the horizontal guide rail 404；The cross sliding clock 410 drives the lifting action component level to move, the lifting electricity
Machine 405 is located at the bottom side of the lifting action part, drives the lifting synchronous belt 406, to drive the lifting to slide
Block 408 carries out lifting action, and the elevation sensor 407 is located at the lifting synchronous belt 406 of the lifting action section upper
Side；Code reader 517 is set in the montant bottom of the portal frame 412, for reading sampling device（1）Rack for test tube 101
In multiple samples 102 information.
17. Biochemical Analyzers as claimed in claim 1, it is characterised in that：Also include device for discharging（7）, the device for discharging
（7）Including bearing 701, motor 702, ball screw 703, ball nut set, discharge arm 705, near-end inductor 706, sensing chip
707th, distal end inductor 708, guide plate 709, the ball screw 703 are driven the discharge arm 705, and the discharge arm 705 is pushed away
Dynamic spent reagent senses institute in the guide plate 709 by the near-end inductor 706, sensing chip 707, distal end inductor 708
The positional information of discharge arm 705 is stated, the sensing chip 707 is arranged on the discharge arm 705, and both holding positions are consistent.
18. Biochemical Analyzers as claimed in claim 1, it is characterised in that：Also include assembly of the plunger pump（9）；The plunger displacement pump
Component（9）Including bearing 901, motor 902, plunger displacement pump 903, pump inlet 904, pump discharge 905, magnetic valve SV2906；The branch
Seat 901 includes being mutually perpendicular to bottom plate and vertical plate, and the bottom plate is used for the assembly of the plunger pump（9）It is fixed on the bottom
Seat（12）On, the vertical plate is used to fix the motor 902, plunger displacement pump 903, pump inlet 904, pump discharge successively from bottom to up
905th, magnetic valve SV2906.
19. Biochemical Analyzers as claimed in claim 1, it is characterised in that：Also include bellows pumping element（10）；The membrane pump
Component（10）Including bearing 1001, barrier film waste drains pump 1002, barrier film liquid feeding pump 1003, magnetic valve 1004, magnetic valve SV11005,
The barrier film waste drains pump 1002, barrier film liquid feeding pump 1003 are set from bottom to top, and the magnetic valve 1004, magnetic valve SV11005 put down
Row is set, on the barrier film liquid feeding pump 1003.
20. a kind of detection methods of Biochemical Analyzer, it is characterised in that comprise the following steps：
（1）By chip cartridges（11）It is fixed on incubating device（3）In be incubated；
（2）Incubating device（3）Edge is moved straightly to sampling module（4）Downside, addition sample to chip cartridges（11）In；
（3）Mobile device makes the incubating device（3）In chip cartridges（11）Moved to along the vertical direction of line slideway and shaken up
Module（5）In, carry out shaking up operation；
（4）After the completion of shaking up, the incubating device is moved to（3）Middle incubation, and the movement incubating device（3）Incubation slot
311 arrive detecting position；
（5）Detection means（6）To the incubating device（3）In completed to shake up, be incubated the chip cartridges of operation（11）Detected.
21. detection methods as claimed in claim 20, it is characterised in that：The step（1）Filled including being conveyed by chip cartridges
Put（2）By chip cartridges（11）It is transported to the incubating device（3）It is fixed, or manually directly by chip cartridges（11）Put
Put the incubating device（3）It is fixed.
22. detection methods as claimed in claim 20, it is characterised in that：The step（2）Including incubating device（3）Along straight line
Guide rail or so is moved straightly to sampling module（4）Downside, samples module（4）Detect accordingly to chip cartridges（11）Afterwards, movement takes
Sample pin is to sampling device（1）In sample in be sampled, samples taken is then added to chip cartridges（11）In.
23. detection methods as claimed in claim 20, it is characterised in that：The step（3）Module is shaken up including described（5）Will
The chip cartridges of sample are added（11）From the incubating device（3）In by eccentric driving lever 509 along with line slideway or so straight line
Mobile vertical direction is transferred to, the movement chip cartridges（11）To shaking up module（5）In shake up groove 511, when detecting
State chip cartridges（11）After entering into described shaking up in groove 511, startup shakes up motor 508 and is shaken up.
24. detection methods as claimed in claim 20, it is characterised in that：The number of times for shaking up operation and required reaction reagent
Total quantity match.
25. detection methods as claimed in claim 20, it is characterised in that：The step（4）Completed including as follows including shaking up
Step：
1）, when only a kind of reagent and example reaction, then once shaken up operation；
2）, when need two kinds of reagents and example reaction when, then shaken up operation twice, specifically include following steps：
2-1）, first sample is added in the first reagent, carry out shaking up operation for the first time, temperature is then controlled in incubation slot
Reacted；
2-2）, second reagent be added to step 2-1）In reagent after the completion of reaction, behaviour then will be for the second time shaken up
Make, control temperature to be reacted after the completion of shaking up.
26. detection methods as claimed in claim 20, it is characterised in that：The step（4）After the completion of shaking up, by inclined
Heart driving lever 509 is by chip cartridges（11）Pull back to the incubating device（3）Incubation slot 311 in, start the electricity of the downside of incubation slot 311
Submodule 308 carries out temperature control, and is thermally shielded by thermal insulation board 307, radiator 306, radiated with accurate regulating and controlling temperature, and
Along the incubating device（3）On line slideway move the incubation slot 311 and arrive detection means（6）Side.
27. detection methods as claimed in claim 20, it is characterised in that：The step（5）Including detection means（6）By dialling
Bar 609 transfers to the incubating device（3）Incubation slot 311 in completed to shake up the chip cartridges of operation（11）, the movement chip
Box（11）To detection components, colorimetric or scattering turbidimetry detection are carried out, and detection information is fed back, be transferred to control device.
28. detection methods as claimed in claim 20, it is characterised in that：After being additionally included in completion detection, the chip that will be detected
Box（11）Carry out discharging.
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| CN201710300410.1A CN106932601B (en) | 2017-05-02 | 2017-05-02 | A kind of Biochemical Analyzer and its detection method |
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| CN201710300410.1A CN106932601B (en) | 2017-05-02 | 2017-05-02 | A kind of Biochemical Analyzer and its detection method |
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| CN111443193A (en) * | 2020-03-25 | 2020-07-24 | 北京海格莱生物科技有限公司 | Synthesize control by temperature change incubator |
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