CN106596989B - A kind of automatic lmunoassays analyzer and detection method - Google Patents
A kind of automatic lmunoassays analyzer and detection method Download PDFInfo
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- CN106596989B CN106596989B CN201710064722.7A CN201710064722A CN106596989B CN 106596989 B CN106596989 B CN 106596989B CN 201710064722 A CN201710064722 A CN 201710064722A CN 106596989 B CN106596989 B CN 106596989B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00524—Mixing by agitating sample carrier
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Abstract
This application involves a kind of automatic lmunoassays analyzer and detection methods, including sampling device (1), reagent card conveying device (2), feeding mechanism (3), incubating device (4), it punctures sampling assemble (5), cleaning assembly (6), device for discharging (7), detection device (8), assembly of the plunger pump (9), bellows pumping element (10), above-mentioned module coupled system control module combines, each device cooperates, the automatic purpose for carrying out immune quantitative analysis is realized jointly, quantitative analysis can be carried out to a variety of samples, improve detection efficiency, and requirement is reduced to the professional standards of tester.
Description
Technical field
The present invention relates to a kind of automatic lmunoassays analyzer and detection methods, belong to the inspection of the immunoassays such as fluorescence and colloidal gold
Survey head of a bed diagnostic field.
Background technique
Full-automatic quantitative immunity analysis instrument especially mostly uses the full-automatic fluorescence immunity analyzer of rotating disk mechanism, just like
Lower deficiency:
1) sample different in size for incubation time, analyzer can only uniformly be analyzed by same incubation time, be drawn
Play inconvenient for operation and inefficiency；
2) reagent that rotating disk mechanism is placed, interruption is transported to incubation mechanism, waiting for a long time inefficient, such as patent application
CN201410836485.8 discloses a kind of full-automatic fluorescence coulometric analysis device and implementation method, and reaction disk module 4 is to turn
Disk mode, not only volume is big, but also reacts waiting for a long time；Patent application CN201510289808.0 discloses a kind of three-dimensional fixed
Test card, is equally placed in test card carrier by position rotating disc type entry dry type fluorescence detector, using turntable into
Row test, there are the spacing between reagent card is big, reaction efficiency inadequate problem when the carousel mode is arranged, is between card slot
It is larger to occupy volume for radial setting.
3) the general usual volume of fluorescent quantitative detector is larger in the prior art, and it is inconvenient to carry, and is not easy to examine immediately
It tests, limits it and having inconvenient traffic, the development of under-developed area.
4) when carrying out quantitative fluorescence analysis in the prior art, need to add reagent manually, operating process is complicated, for operation
The level requirement of person is higher, meanwhile, condition is harsh, and it is easy to operate improper, cause result incorrect, meanwhile, exist in the prior art
When to reagent card detection, mobile reagent card itself is needed, the accuracy decline of testing result is be easy to cause.
Due to the combination and marker material higher cost of antigen-antibody, it is aobvious that large area cannot be equally made into chemical reagent
Color, and background has the impurity such as water, blood, marker material that infiltration is caused unevenly to increase the difficulty and precision of detection, how
It keeps the volume of POCT product small, the stability detected and sensitivity are improved while easy to carry and improves efficiency, be this
Technical field urgent problem to be solved.
Summary of the invention
To achieve the above object, in the present invention, when can be according to being incubated in existing Full-automatic quantitative immunity analysis instrument structure
Between length intelligence is successively full-automatic realizes detection, due to being incubated for when overcoming existing Full-automatic quantitative immunity analysis instrument comprehensive detection
Time difference such as needs to wait at the inefficiency the drawbacks of.
10 kinds of at least three kinds of pattern detections or more project can be once loaded, the reaction time can be accurately controlled.Since sample-adding
Terminate to detection, the reaction time is consistent, and sample-adding precision is high, and sample-adding progress can be according to setting item by system prompt.In addition, sample and
Detection project can be freely combined, and can carry out the independent assortment of disparity items and different samples according to sample needs, improve
Detection efficiency.
It is an object of the present invention to provide in a kind of quickly accurate detection patient blood (whole blood or composition blood) and other samples
Cause of disease marker, for the diagnosis of various diseases especially emergency treatment common acute disease and severe, easy to operate efficiently realization is complete
Automate immune quantitative detection device.
To solve above-mentioned technical problem: the application proposes a kind of automatic lmunoassays analyzer, including sampling assemble 5, clear
Component 6, incubating device 4 and detection device 8 are washed, the detection device 8 is located at 4 top of incubating device, institute
It states incubating device 4 to include the 4th linear guide 407, be incubated for monitor station 409, be provided at least on the incubation monitor station 409
Two parallel reagent card slots, the incubation monitor station 409 can move linearly along the 4th linear guide 407 or so；It is described
Detection device 8 includes the 8th linear guide 806, detector 804, and the detector 804 of the detection device 8 is along the described 8th
806 tandem of linear guide is mobile；4th linear guide 407 is mutually perpendicular to the 8th linear guide 806；It is described
8 pairs of detection device are incubated for the reagent card completed and detect.
The reagent card in the incubating device 4 can be kept fixed to detect to it, the cleaning assembly 6
Agitating device the liquid mixed in cup is mixed well, and be able to use cleaning device to taking in sampling assemble 5
Sample needle is cleaned.
The automatic lmunoassays analyzer, wherein the sampling assemble 5 can according to the automatic direct sample of program setting,
Or it is sampled again after automatic puncturing.
The automatic lmunoassays analyzer, wherein the detection device 8 is located at the 4th with the sampling device 1
Two sides of linear guide 407 or positioned at the same side of the 4th linear guide 407.
The automatic lmunoassays analyzer, wherein the incubating device 4 is movable incubating device, further includes temperature control
Electronic module 410, the temperature control electronic module 410 are located at the bottom surface for being incubated for monitor station 409, can be with the incubation monitor station
409 is mobile, for controlling the temperature for being incubated for monitor station 409.
The automatic lmunoassays analyzer, wherein the incubating device 4 further includes that the 4th motor the 401, the 4th is synchronous
Belt 402, the 4th proximal end inductor 403, the 4th sensing chip 404, support 405, the 4th distal end inductor 406, Four-slider, institute
State the 4th proximal end inductor 403, the 4th distal end inductor 406 is set at the both ends of the 4th linear guide 407, described
The side that four synchronous belts 402 are located at the 4th linear guide 407 is arranged in parallel, and the incubation monitor station 409 is fixedly installed
It is snapped onto the 4th linear guide 407 in the top of the Four-slider, and by the Four-slider, the 4th electricity
Machine 401 drives the 4th synchronous belt 402 to act.
The automatic lmunoassays analyzer, wherein the sampling device 1 include rack for test tube 101, the first support 104,
Initial level sensor 105, first motor 107, terminal inductor 108 and the multiple samples being placed in the rack for test tube 101
102, sample or buffer 103, first support 104 place the linear platform of plane of the rack for test tube 101, flat in straight line
Initial sensor 105 is arranged in the entry position of platform, baffle is arranged in the end of linear platform, and terminal is arranged in the lower end of baffle
Inductor 108, the first motor 107 are set to the side of the linear platform, connect and act with moving gear 106, institute
State the bottom that gear 106 is set to the linear platform, the tooth-like part intermeshing of gear 106 and rack for test tube bottom.
The automatic lmunoassays analyzer, wherein the detection device 8 includes replaceable detector, the inspection
Gauge head includes at least one fluorescence detection head, colloidal gold detector.
The detection device 8 further includes the 8th motor 801, the 8th screw rod 802, the 8th screw rod mother set 803, the 8th sliding block
805, the 8th sensing chip 807, the 8th inductor 808, motor mounting plate 809, the 8th support 810, the 8th screw rod 802 is
It under the driving of eight motors 801, controls the detector 804 and is moved along 806 tandem of the 8th linear guide, with to being incubated for
Reagent card is detected, and the 8th inductor 808 is used to sense the location information of detector, and the detector 804 is higher than institute
It states and is incubated for monitor station 409.
The automatic lmunoassays analyzer, wherein the cleaning assembly 6 includes mixing cup 602, Washing cup 610, institute
State and mix that cup 602, Washing cup 610 are placed side by side, it is described mix various samples that 602 pairs of the cup sampling assembles 5 take out into
Row mixes, and the Washing cup 610 all cleans the every sub-sampling of the sampling assemble 5 later.
The automatic lmunoassays analyzer, wherein the cleaning assembly 6 further includes the 6th cleaning solution import 601, branch
Hold piece 603, the 6th waste liquid outlet 604, magnetic couplings mixing component 605, the 6th motor 606, the 6th bracket 607, the 7th waste liquid
The 608, the 7th cleaning solution import 609 is exported, the supporting slice 603 is for fixing the cleaning solution import 601, the 6th waste liquid
Outlet 604 is located at the lower part for mixing cup 602, and the 7th cleaning solution import 609 is set to the side of Washing cup 610, institute
The bottom that the 7th waste liquid outlet 608 is set to the Washing cup 610 is stated, 605 pairs of mixing cups 602 of magnetic couplings mixing component carry out
It stirs and evenly mixs.
The automatic lmunoassays analyzer, wherein the sampling assemble 5 includes portal frame 518, punctures sampling probe
513, component, horizontal balance component are moved up and down, the horizontal balance component, which drives, punctures the back-and-forth motion of sampling probe 513, described
Up and down action component drives puncture sampling probe 513 to move up and down and is sampled, and the horizontal balance component is located at the portal frame
On 518 cross bar.
The automatic lmunoassays analyzer, wherein the up and down action component includes moving up and down motor the 501, the 5th
Screw rod 510, the 5th sliding block 511, the 5th sensing chip 512；The horizontal balance component includes moving horizontally motor the 502, the 5th together
Step belt 503, the 5th linear guide 504,6th sense answer device 505, bevel gear set 506, splined shaft 507, the 11st sensing chip
508, the 12nd inductor 509；In lower end setting the cleaning chamber 514, the 5th rinse liquid outlet for moving up and down component
515, the 5th cleaning solution import 516 cleans the puncture sampling probe 513, in the vertical bar lower end of the portal frame 518
Code reader 517 is set.
The automatic lmunoassays analyzer, wherein it further include reagent card conveying device 2 and feeding structure 3, it is described
Multiple reagent cards are moved in parallel the feeding structure 3 by reagent card conveying device 2, and the feeding structure 3 successively will
Each of the multiple reagent card is pushed to the corresponding position for being incubated for monitor station 409.
The automatic lmunoassays analyzer, wherein the reagent card conveying device 2 includes the second motor 201, second
Synchronous belt 202, drive pulley wheel assembly 203, the second belt 204, cover board 205, base 206, the second code reader 207, it is described
The width of belt 204 and the length of reagent card match, and the cover board 205 keeps the covering of certain intervals with the belt 204
On 204 top of belt, the certain intervals are greater than or equal to the thickness of reagent card, less than the width of reagent card, described the
Two code readers 207 are located at the side of the inlet of the cover board 205, and are higher than the cover board 205, the letter for reading reagent card
Breath.
The automatic lmunoassays analyzer, wherein the feeding structure 3 includes third motor 301, the synchronous skin of third
Band 302, third sliding block 303, third guide rail 304, pusher strut 305, third sensing chip 306, third inductor 307, it is described to push away
Material strut 305 is moved along third guide rail 304, snaps into the corresponding position for being incubated for monitor station 409 for pushing reagent, described
Third sensing chip 306 is consistent with 305 position of pusher strut, and the position of third sensing chip 306 is detected by third inductor 307
Set the position to judge pusher strut 305.
The automatic lmunoassays analyzer, wherein further include device for discharging 7, the device for discharging 7 includes the 7th
Support 701, the 7th motor 702, the 7th screw rod 703, nut set 704, discharge arm 705, the sense of the 7th proximal end inductor the 706, the 7th
Piece 707, the 7th distal end inductor 708, spent reagent collection box 709 are answered, the 7th screw rod 703 is driven the discharge arm 705, institute
Stating discharge arm 705 pushes spent reagent into the spent reagent collection box 709, is felt by the 7th proximal end inductor the 706, the 7th
Piece 707, the 7th distal end inductor 708 is answered to sense the location information of the discharge arm 705, the 7th sensing chip 707 setting exists
On the discharge arm 705, the two holding position is consistent.
The automatic lmunoassays analyzer, wherein further include assembly of the plunger pump 9, bellows pumping element 10, the column
Filling in pump assembly 9 includes support 901, motor 902, plunger pump 903, pump inlet 904, pump discharge 905, the 9th solenoid valve 906；Institute
Stating bellows pumping element 10 includes support 1001, diaphragm waste drains pump 1002, diaphragm liquid feeding pump 1003, the first solenoid valve 1004, the
Two solenoid valves 1005, according to setting program, system control assembly of the plunger pump 9, bellows pumping element 10 and respective line, puncture are taken
Sample needle quantitatively can draw or inject sample, buffer, cleaning solution between each position, go out in needle again after can also sucking air
Residual liquid, and waste liquid is made to inject waste liquid recovery apparatus.
A kind of detection method of automatic lmunoassays analyzer, includes the following steps:
(1) detection information is set, the reagent card that need to be detected is fixed in incubating device 4, an examination is fixed in every addition
Agent card, incubating device 4 move right a distance along straight line；
(2) sample information is added, sample is sampled by sampling assemble 5, the buffer of extraction is mixed well into place
It is added in the reagent card of the incubating device 4 after reason or directly by sampling assemble 5；
(3) it is incubated for control, according to the temperature requirements of each reagent card, passes through the temperature control electronic module in incubating device 4
Temperature control is carried out, and is incubated for according to the different reaction time；
(4) testing result information is fed back, and keeps reagent card motionless, and 8 motion detection head 804 of detection device is advised to reaching
The reagent card of fixed incubation time is detected, and result is fed back to system control device；
(5) discharging after the completion of detection, carries out discharging by device for discharging 7.
The detection method of the automatic lmunoassays analyzer, wherein specifically included in the step 1: from reagent card
Reagent card is placed in 2 inlet of conveying device, and the second code reader 207 reads the information for the reagent card placed, and judges that information is
It is no correct, if incorrect, alert, if correctly, conveying multiple reagents by reagent card conveying device 2
It snaps into feeding structure 3, the feeding structure 3 successively pushes each of the multiple reagent card and fills to the incubation
Set 4 fixation position；Or the reagent card that detects will directly be needed to be manually inserted into the fixation position of the incubating device 4
In.
The detection method of the automatic lmunoassays analyzer, wherein specifically included in the step 2: the sampling
Component 5 can sample again after direct sample automatic in sampling device 1 or automatic puncturing according to program setting, by the sample of sampling
Originally be placed in mix cup 602 in, after every sub-sampling, by the puncture sampling probe 513 of sampling assemble 5 be placed in Washing cup 610 into
Row cleaning mixes the sample mixed in cup 602, until all sample extraction completions then by puncturing sampling probe
The sample of mixing is added in the reagent card of the incubating device 4 and is incubated for by 513.
The detection method of the automatic lmunoassays analyzer, wherein specifically included in the step 3: the temperature control
Electronic module 410 the bottom of the incubation monitor station 409 of incubating device 4 with adjust reagent snap into demand at a temperature of, it is described
Detection device 8 receives system control device for the incubation time information of each reagent card, realizes that intelligences combination is successively efficient
Ground detection.
A kind of Full-automatic quantitative immunity analysis instrument of the invention has the advantages that
1 under the control of system control module, sampling device, incubating device, sampler, data acquisition device, reagent
Card device and system control module combine, and each device cooperates, and realize to carry out being immunized automatically jointly and determine
Measure the purpose of analysis.
2 instruments puncture sampling assemble can be according to sampling again after the automatic direct sample of program setting or automatic puncturing.
3 only need to set project to be measured in system, and instrument is sequentially placed required reagent by sample prompt, is not required to shake
It is even, uncap, the operation such as pre-dilution, automatic detection analysis can be started and export result.
4, by using cleaning device, eliminate the use of medical disposable material, operating cost reduces, environmentally protective；Pass through
The motor for mixing the setting of cup lower part drives the agitating device in mixing cup the liquid mixed in cup such as to mix well.Each portion
Part mutual cooperation, co-ordination under control system control, realizes instrument intelligent prompt and false alarm, further improves this
The degree of automation and performance of analyzer.
5 reagent cards are fixed, and core detector can be detected along guide rail linear movement in detection device, compared with it
He can reach higher detection accuracy by mobile reagent card, by mobile detector, keep the stabilization of reagent card, reduces reagent card and moves
It is dynamic to cause the variations such as reaction environment, temperature that reaction result is caused error occur.
6 a kind of quantitative immunological detection methods of the invention, using above-mentioned automatic lmunoassays analyzer, to a variety of samples
Existing automatic intelligent instrumental quantitative analysis is realized, detection range is expanded, improves detection efficiency, and to the special of tester
Industry level reduces requirement.
Incubation reaction platform is set in 7 present invention mode of linear movement, the disk of structure compared with the existing technology
Mode is simpler, meanwhile, it is arranged between card slot by closely parallel mode, middle disk is at radial setting compared with the prior art
The obvious volume of the mode of card slot is much smaller, keeps analyzer of the invention easy to carry, and the application is skilful by the design of multiple structures
It is wonderful, keep detection accuracy higher, using effect is prominent.
8 due to detection accuracy raising, using the reduction of volume, the cost of equipment is greatly reduced.
Detailed description of the invention
Fig. 1 is automatic lmunoassays analyzer schematic diagram of internal structure；
Fig. 2 is sampling device structural schematic diagram；
Fig. 3 is reagent card conveying device structural schematic diagram；
Fig. 4 is feeding mechanism schematic diagram；
Fig. 5 is movable incubating device structural schematic diagram；
Fig. 6 is to puncture sampling assemble structural schematic diagram；
Fig. 7 is to mix cleaning component structural schematic diagram；
Fig. 8 is device for discharging structural schematic diagram；
Fig. 9 is structure of the detecting device schematic diagram；
Figure 10 is assembly of the plunger pump structural schematic diagram；
Figure 11 is bellows pumping element structural schematic diagram.
Specific embodiment
The application is described in further detail with reference to the accompanying drawing, it is necessary to it is indicated herein to be, implement in detail below
Mode is served only for that the application is further detailed, and should not be understood as the limitation to the application protection scope, the field
Technical staff can make some nonessential modifications and adaptations to the application according to above-mentioned application content.
Embodiment one:
As shown in Figure 1, proposing a kind of automatic lmunoassays analyzer, including the conveying of sampling device 1, reagent card for the application
Device 2, incubating device 4, punctures sampling assemble 5, cleaning assembly 6, device for discharging 7, detection at feeding mechanism 3
Device 8, assembly of the plunger pump 9, bellows pumping element 10.
It is illustrated in figure 2 sampling device structural schematic diagram, the sampling device 1 includes rack for test tube 101, support 104, just
Beginning level sensor 105, motor 107, terminal inductor 108 and the multiple samples 102 being placed in the rack for test tube 101, examination
Sample or buffer 103, the support 104 places the linear platform of plane of the rack for test tube 101, in the entrance position of linear platform
Initial sensor 105 is installed, baffle is set in the end of linear platform, and terminal inductor 108 is set in the lower end of baffle,
The motor 107 is set to the side of the linear platform, connects and acts with moving gear 106, the gear 106 is set to
The tooth-like part of the bottom of the linear platform, gear 106 and rack for test tube bottom is intermeshed.
It is illustrated in figure 3 reagent card conveying device structural schematic diagram, is illustrated in figure 4 feeding structure schematic diagram, wherein also
Including reagent card conveying device 2 and feeding structure 3, the reagent card conveying device 2 moves in parallel multiple reagent cards
To the feeding structure 3, successively each by the multiple reagent card is pushed to the incubation inspection to the feeding structure 3
The corresponding position of scaffold tower 409.
Wherein, the reagent card conveying device 2 include motor 201, synchronous belt 202, drive pulley wheel assembly 203,
Belt 204, cover board 205, base 206, code reader 207；The code reader 207 is set to the side of reagent card conveying device 2,
And it is higher than the cover board 205.The feeding structure 3 includes motor 301, synchronous belt 302, sliding block 303, guide rail 304, pusher
Strut 305, sensing chip 306, inductor 307, the pusher strut 305 are moved along guide rail 304, for pushing reagent to centainly
Position, the sensing chip 306 is consistent with 305 position of pusher strut, passes through the position that inductor 307 detects sensing chip 306
Set the position to judge pusher strut 305.
The side of guide rail 304 is arranged in the motor 301, and guide rail 304 may be selected to be cylindrical column, and motor 301 rotates
Synchronous belt 302 is driven, the synchronous belt 302 drives the pusher strut 305 to move along cylindrical column, inductor
307 settings are arranged in 304 end of guide rail, the sliding block 303 in 305 lower end of pusher strut.
The width of the belt 204 and the length of reagent card match, and the cover board 205 keeps one with the belt 204
Surely what is be spaced is covered on 204 top of belt, and the certain intervals are greater than or equal to the thickness of reagent card, less than reagent card
Width, the code reader 207 is located at the side of the inlet of the cover board 205, and is higher than the cover board 205, for reading examination
The information of agent card, the cover board 205 use transparent material, and can be used to observe makes reagent card move and prevent as requested
Dirt waterproof.
As shown in figure 5, being movable incubating device structural schematic diagram, the incubating device 4 includes linear guide 407, incubates
Monitor station 409 is educated, the incubation monitor station 409 can move linearly along the linear guide 407 or so, the detection device 8
Detector 804 by being moved along 806 tandem of linear guide, the reagent card in the incubating device 4 can be kept
It is fixed to be detected to it.
The incubating device 4 further includes motor 401, synchronous belt 402, proximal end inductor 403, sensing chip 404, support
405, distal end inductor 406, sliding block (not identifying in figure), temperature control electronic module 410, the proximal end inductor 403, distal end are felt
Device 406 is answered to be set at the both ends of the linear guide 407, the synchronous belt 402 is located at the side of the linear guide 407
It is arranged in parallel, the monitor station 409 that is incubated for is fixed at the top of the sliding block, while described in being snapped by the sliding block
In linear guide 407, the motor 401 drives the synchronous belt 402 to act, and incubation monitor station 409 is enable to lead along straight line
Rail or so linear motion.The proximal end inductor 403, sensing chip 404, the sensing of distal end inductor 406 are incubated for the position of monitor station 409
Confidence breath, the sensing chip 404 are used to identify the position in the linear guide 407 for being incubated for monitor station.
It is illustrated in figure 6 and punctures sampling assemble schematic diagram, wherein the sampling assemble 5 includes portal frame 518, punctures
Sampling probe 513 moves up and down component, horizontal balance component, and the horizontal balance component moves before and after driving puncture sampling probe 513
Dynamic, the up and down action component drives puncture sampling probe 513 to move up and down and is sampled, and the horizontal balance component is located at described
On the cross bar of portal frame 518.
The up and down action component includes moving up and down motor 501, screw rod 510, sliding block 511, sensing chip 512；The water
Flat action component include move horizontally motor 502, synchronous belt 503, linear guide 504, inductor 505, bevel gear set 506,
Splined shaft 507, sensing chip 508, inductor 509；The cross bar for moving up and down motor 501 and the portal frame 518 being set
One end, the position for moving horizontally motor 502 and the wherein vertical top and cross bar handover of the portal frame 518 being set
It sets, the linear guide 504 is arranged in parallel with cross bar, and 504 downside of linear guide is arranged close to wherein one in the inductor 505
The left side of the splined shaft 507 is arranged in close to upper position, for incuding the induction in vertical bar position, the inductor 509
Piece 512.It is right in lower end setting the cleaning chamber 514, rinse liquid outlet 515, cleaning solution import 516 for moving up and down component
The sampling probe 513 is cleaned, and code reader 517 is arranged in the vertical bar lower end of the portal frame 518.
513 end of puncture sampling probe is installed on the sliding block 511, and can be under the action of sliding block 511 up and down
Movement is punctured, and the sliding block 511 is installed on the ball screw 510, and can be in the screw rod 510 and synchronous belt
Switch the puncture sampling probe 513 between sampling position, buffer storehouse, mixing cup and loading position, it is described to wear
It pierces sampling probe 513 and passes through the cleaning chamber 514；The code reader 517 is set to the lower end of the vertical bar of the portal frame 518
Portion.The sampling assemble 5 can be according to sampling again after the automatic direct sample of program setting or automatic puncturing.
It is illustrated in figure 7 and mixes cleaning assembly schematic diagram, wherein the cleaning assembly (6) includes mixing cup 602, cleaning
Cup 610, the mixing cup 602, Washing cup 610 are placed side by side, described to mix the more of 602 pairs of the cup taking-ups of sampling assembles 5
Kind sample is mixed, and the Washing cup 610 all cleans the every sub-sampling of the sampling assemble 5 later.
The cleaning assembly 6 further includes the 6th cleaning solution import 601, supporting slice 603, the 6th waste liquid outlet 604, magnetism
Coupled stir component 605, motor 606, bracket 607, the 7th waste liquid outlet 608, the 7th cleaning solution import 609, the supporting slice
603 for fixing the 601 cleaning solution import 601 of the 6th cleaning solution import, and the 6th waste liquid outlet 604 is located at the mixing
The lower part of cup 602, the 609 cleaning solution import 609 of the 7th cleaning solution import are set to the side of Washing cup 610, and the described 7th
Waste liquid outlet 608 is set to the bottom of the Washing cup 610, and 605 pairs of mixing cups 602 of magnetic couplings mixing component are stirred mixed
It is even.
The agitating device of the cleaning assembly 6 mixes well the liquid mixed in cup, and is able to use cleaning
Device is cleaned to cup is mixed, after the puncture sampling assemble 5 can be according to the automatic direct sample of program setting or automatic puncturing
It samples again.
It is illustrated in figure 8 device for discharging schematic diagram, wherein further include device for discharging 7, the device for discharging 7 includes
Support 701, motor 702, ball screw 703, ball nut set 704, discharge arm 705, proximal end inductor 706, sensing chip 707,
Distal end inductor 708, spent reagent collection box 709.The ball screw 703 is driven the discharge arm 705, the discharge arm 705
It pushes spent reagent into the spent reagent collection box 709, passes through the proximal end inductor 706, sensing chip 707, distal end inductor
The location information of the 708 sensing discharge arms 705, the sensing chip 707 are arranged on the discharge arm 705, the two holding position
It sets consistent.The detection device 8 is located at the two sides of linear guide 407 with the sampling device 1 or is located at linear guide 407
The same side.
It is illustrated in figure 9 structure of the detecting device schematic diagram, wherein the detection device 8 further includes motor 801, screw rod
802, screw rod mother set 803, sliding block 805, sensing chip 807, inductor 808, motor mounting plate 809, support 810, the screw rod 802
Under the driving of motor 801, controls the detector 804 and moved along 806 tandem of linear guide, to the reagent being incubated for
Card is detected, and the inductor 808 is used to sense the location information of detector, and the detector 804 is examined higher than the incubation
Scaffold tower 409.
The detector is quantitative fluorescence analysis detector, for carrying out fluorescence detection to reagent card.
As shown in Figure 10 it is assembly of the plunger pump schematic diagram, is as shown in figure 11 bellows pumping element schematic diagram, wherein further include
Assembly of the plunger pump 9, bellows pumping element 10, the whole assembly of the plunger pump 9 is in upper and lower arrangement, from bottom to top successively
For support 901, motor 902, plunger pump 903, pump inlet 904, pump discharge 905, the 9th solenoid valve 906, wherein the support
901, motor 902, plunger pump 903 are fixed by elongated plates, and the solenoid valve 906 is set to the side of elongated plates upper end
Face position；The bellows pumping element 10 includes support 1001, diaphragm waste drains pump 1002, diaphragm liquid feeding pump 1003, the first electromagnetism
Valve 1004, second solenoid valve 1005, the diaphragm waste drains pump 1002, diaphragm liquid feeding pump 1003 are parallel side by side, the solenoid valve
1004, solenoid valve 1005 is parallel side by side, be arranged in diaphragm waste drains pump 1002, the parallel juxtaposed positions of diaphragm liquid feeding pump 1003 it is upper
Portion.The assembly of the plunger pump 9 is a kind of constant displacement pump, is determined by solenoid valve open and close corresponding on component, it can be achieved that puncturing sampling probe
Amount, which injects liquid, can also quantitatively suck liquid, can also suck and go out residual liquid in needle after air again, the diaphragm pump group
Part 10 is a kind of micropump, can be flowed out after making its intraluminal liquid pressing by solenoid valve open and close corresponding on component.According to
Setting program, system control assembly of the plunger pump 9, bellows pumping element 10 and respective line, and puncturing sampling probe can be in each position
Between quantitatively draw or inject sample, buffer, cleaning solution, can also suck and go out residual liquid in needle after air again, and make
Waste liquid injects waste liquid recovery apparatus
A kind of detection method of automatic lmunoassays analyzer, includes the following steps:
1 setting detection information, the reagent card that need to be detected is fixed in incubating device 4, a reagent is fixed in every addition
Card, incubating device 4 move right a distance along straight line；
2 addition sample informations, are sampled sample by sampling assemble 5, by Extraction buffer etc. and mix well
It is added in the reagent card of the incubating device 4 after processing or directly by sampling assemble 5；
3 are incubated for control, according to the temperature requirements of each reagent card, by the temperature control electronic module in incubating device 4 into
Trip temperature control, and be incubated for according to the different reaction time；
4 testing result information feedback, keeps reagent card motionless, and 8 motion detection head 804 of detection device is provided to reaching
The reagent card of incubation time detected, and result is fed back into system control device；
5 dischargings after the completion of detection, carry out discharging by device for discharging 7.
The detection method of the automatic lmunoassays analyzer, wherein specifically included in the step 1: from reagent card
Reagent card is placed in 2 inlet of conveying device, and just whether code reader 207 reads the information for the reagent card placed, and judge information
Really, if it is incorrect, alert, if correctly, conveying multiple reagents by reagent card conveying device 2 and snapping into
In feeding structure 3, the feeding structure 3 successively pushes each of the multiple reagent card to the incubating device 4
Fixation position；Or directly the reagent card detected will be needed to be manually inserted into the fixation position of the incubating device 4.
The detection method of the automatic lmunoassays analyzer, wherein specifically included in the step 2: the sampling
Component 5 can sample again after direct sample automatic in sampling device 1 or automatic puncturing according to program setting, by the sample of sampling
Originally be placed in mix cup 602 in, after every sub-sampling, by the puncture sampling probe 513 of sampling assemble 5 be placed in Washing cup 610 into
Row cleaning mixes the sample mixed in cup 602, until all sample extraction completions then by puncturing sampling probe
The sample of mixing is added in the reagent card of the incubating device 4 and is incubated for by 513.
The detection method of the automatic lmunoassays analyzer, wherein specifically included in the step 3: the temperature control
Electronic module 410 the bottom of the incubation monitor station 409 of incubating device 4 with adjust reagent snap into demand at a temperature of, it is described
Detection device 8 receives system control device for the incubation time information of each reagent card.When incubation reaches the stipulated time, move
Make detector forward movement, the information after detection reaction simultaneously feeds back to system control device, and after having detected, detector is moved backward
It resets.
Embodiment two:
Detection device 8 includes detector, and the detector can be replaced manually, and colloidal gold detection can be selected in the detector
Head, for carrying out colloidal gold detection, other structures or component are identical as fluorescence detection device.
A kind of automatic lmunoassays analyzer of the invention has the advantages that 1) under the control of system control module, into
Sampling device, incubating device, sampler, data acquisition device, reagent card device and system control module are organically combined one
It rises, each device cooperates, and realizes the automatic purpose for carrying out immune quantitative analysis jointly.
2) this instrument puncture sampling assemble can be according to being sampled again after the automatic direct sample of program setting or automatic puncturing.
3) only project to be measured need to be set in system, instrument is sequentially placed required reagent by sample prompt, is not required to shake
It is even, uncap, the operation such as pre-dilution, automatic detection analysis can be started and export result.
4) by using cleaning device, the use of medical disposable material is eliminated, operating cost reduces, environmentally protective；Pass through
The motor for mixing the setting of cup lower part drives the agitating device in mixing cup the liquid mixed in cup such as to mix well.Each portion
Part mutual cooperation, co-ordination under control system control, realizes instrument intelligent prompt and false alarm, further improves this
The degree of automation and performance of analyzer.
5) reagent card is fixed, and core detector can be detected along guide rail linear movement in detection device, compared with it
He can reach higher detection accuracy by mobile reagent card, by mobile detector, keep the stabilization of reagent card, reduces reagent card and moves
It is dynamic to cause the variations such as reaction environment, temperature that reaction result is caused error occur.
6) a kind of quantitative immunological detection method of the invention, using above-mentioned automatic lmunoassays analyzer, to a variety of samples
Automatic intelligent instrumental quantitative analysis is realized, detection range is expanded, improves detection efficiency, and to the profession of tester
Level reduces requirement.
7) incubation reaction platform is set in the present invention mode of linear movement, the disk of structure compared with the existing technology
Mode is simpler, meanwhile, it is arranged between card slot by closely parallel mode, middle disk is at radial setting compared with the prior art
The obvious volume of the mode of card slot is much smaller, keeps analyzer of the invention easy to carry, and the application is skilful by the design of multiple structures
It is wonderful, keep detection accuracy higher, using effect is prominent.
8) due to the raising of detection accuracy, using the reduction of volume, the cost of equipment is greatly reduced.
The application includes but is not limited to specific executing agency, transmission and control mechanism, inductive switch described in attached drawing,
Such as be driven usable chain, rack-and-pinion, or other drivings can be used etc., it is done within the spirit and principles of the present invention
Any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention.
Claims (21)
1. a kind of automatic lmunoassays analyzer, it is characterised in that: including sampling assemble (5), cleaning assembly (6), incubating device (4)
With detection device (8), the detection device (8) is located above the incubating device (4), and the incubating device (4) includes the 4th
Linear guide (407) is incubated for monitor station (409), is provided at least two parallel reagent cards on the incubation monitor station (409)
Slot, the incubation monitor station (409) can move linearly along the 4th linear guide (407) left and right；Detection device (8) packet
The 8th linear guide (806), detector (804) are included, the detector (804) of the detection device (8) is led along the 8th straight line
Rail (806) tandem is mobile, when being detected, keeps reagent card fixed, by mobile detector, keeps reagent card
Stablize, reaches higher detection accuracy；4th linear guide (407) is mutually perpendicular to the 8th linear guide (806)；
The detection device (8) is detected to the reagent card completed is incubated for.
2. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: the sampling assemble (5) can set according to program
It is sampled again after fixed automatic direct sample or automatic puncturing.
3. automatic lmunoassays analyzer as claimed in claim 2, it is characterised in that: the detection device (8) and sampling device
(1) positioned at the two sides of the 4th linear guide (407) or positioned at the same side of the 4th linear guide (407).
4. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: the incubating device (4) is movable is incubated for
Device further includes temperature control electronic module (410), and the temperature control electronic module (410) is located at the bottom for being incubated for monitor station (409)
Face, for controlling the temperature for being incubated for monitor station (409).
5. automatic lmunoassays analyzer as claimed in claim 4, it is characterised in that: the incubating device (4) further includes the 4th
Motor (401), the 4th synchronous belt (402), the 4th proximal end inductor (403), the 4th sensing chip (404), the 4th support
(405), the 4th distal end inductor (406) and Four-slider, the 4th proximal end inductor (403), the 4th distal end inductor
(406) it is set at the both ends of the 4th linear guide (407), it is straight that the 4th synchronous belt (402) is located at the described 4th
The side of line guide rail (407) is arranged in parallel, the top for being incubated for monitor station (409) and being fixed at the Four-slider, and
It is snapped on the 4th linear guide (407) by the Four-slider, the 4th motor (401) drive the described 4th is same
Walk belt (402) movement.
6. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: further include sampling device (1), the sample introduction
Device (1) includes rack for test tube (101), the first support (104), initial level sensor (105), first motor (107), terminal induction
Device (108) and the multiple samples (102) being placed in the rack for test tube (101), sample or buffer (103), described first
Support (104) places the linear platform of plane of the rack for test tube (101), the initial sensing of setting in the entry position of linear platform
Device (105) is arranged baffle in the end of linear platform, and terminal inductor (108) is arranged in the lower end of baffle, first electricity
Machine (107) is set to the side of the linear platform, connects and acts with moving gear (106), the gear (106) is set to
The tooth-like part of the bottom of the linear platform, gear (106) and rack for test tube bottom is intermeshed.
7. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: the detection device (8) includes replaceable
Detector, the detector includes at least one fluorescence detection head, colloidal gold detector.
8. automatic lmunoassays analyzer as claimed in claim 7, it is characterised in that: the detection device (8) further includes the 8th
Motor (801), the 8th screw rod (802), the 8th screw rod mother set (803), the 8th sliding block (805), the 8th sensing chip (807), the 8th
Inductor (808), motor mounting plate (809), the 8th support (810), the 8th screw rod (802) is in the 8th motor (801)
Under driving, controls the detector (804) and moved along the 8th linear guide (806) tandem, to the reagent card being incubated for
It is detected, the 8th inductor (808) is used to sense the location information of detector, and the detector (804) is higher than described
It is incubated for monitor station (409).
9. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: the cleaning assembly (6) includes mixing cup
(602), Washing cup (610), the mixing cup (602), Washing cup (610) are placed side by side, and the mixing cup (602) takes to described
The various samples that sample component (5) takes out are mixed, after the Washing cup (610) is to the sampling assemble (5) every sub-sampling
All cleaned.
10. automatic lmunoassays analyzer as claimed in claim 9, it is characterised in that: the cleaning assembly (6) further includes the 6th
Cleaning solution import (601), supporting slice (603), the 6th waste liquid outlet (604), magnetic couplings mixing component (605), the 6th motor
(606), the 6th bracket (607), the 7th waste liquid outlet (608), the 7th cleaning solution import (609), the supporting slice (603) are used for
The fixed cleaning solution import (601), the waste liquid outlet (604) are located at the lower part for mixing cup (602), the cleaning solution
Import (609) is set to the side of Washing cup (610), and the waste liquid outlet (608) is set to the bottom of the Washing cup (610)
Portion, magnetic couplings mixing component (605) are stirred mixing to cup (602) are mixed.
11. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: the sampling assemble (5) includes portal frame
(518), sampling probe (513) are punctured, move up and down component, horizontal balance component, the horizontal balance component, which drives, punctures sampling
Needle (513) is moved forward and backward, and the up and down action component drives puncture sampling probe (513) to move up and down and is sampled, the level
Action component is located on the cross bar of the portal frame (518).
12. automatic lmunoassays analyzer as claimed in claim 11, it is characterised in that: the up and down action component includes up and down
Mobile motor (501), the 5th screw rod (510), the 5th sliding block (511), the 5th sensing chip (512)；The horizontal balance component packet
Include move horizontally motor (502), the 5th synchronous belt (503), the 5th linear guide (504), 6th sense answer device (505), cone tooth
Wheel group (506), splined shaft (507), the 11st sensing chip (508), the 12nd inductor (509)；In the up and down action component
Lower end setting cleaning chamber (514), the 5th rinse liquid outlet (515), the 5th cleaning solution import (516), to it is described puncture take
Sample needle (513) is cleaned, and code reader (517) are arranged in the vertical bar lower end of the portal frame (518).
13. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: further include reagent card conveying device (2) and
Feeding structure (3), the reagent card conveying device (2) move in parallel multiple reagent cards the feeding structure (3), it is described into
Successively each by the multiple reagent card is pushed to the corresponding position for being incubated for monitor station (409) to material structure (3).
14. automatic lmunoassays analyzer as claimed in claim 13, it is characterised in that: reagent card conveying device (2) packet
Include the second motor (201), the second synchronous belt (202), drive pulley wheel assembly (203), the second belt (204), cover board
(205), base (206), the second code reader (207), the width of second belt (204) and the length of reagent card match,
What the cover board (205) and second belt (204) kept certain intervals is covered on the belt (204) top, and described one
Fixed interval is greater than or equal to the thickness of reagent card, and less than the width of reagent card, second code reader (207) is located at the cover board
(205) side of inlet, and it is higher than the cover board (205), the information for reading reagent card.
15. automatic lmunoassays analyzer as claimed in claim 13, it is characterised in that: the feeding structure (3) includes third
Motor (301), third synchronous belt (302), third sliding block (303), third guide rail (304), pusher strut (305), third sense
Piece (306), third inductor (307) are answered, the pusher strut (305) is mobile along third guide rail (304), for pushing reagent
The corresponding position for being incubated for monitor station (409) is snapped into, the third sensing chip (306) and pusher strut (305) position are kept
Unanimously, the position of pusher strut (305) is judged by the position of third inductor (307) detection third sensing chip (306).
16. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: it further include device for discharging (7), it is described to unload
Expect that device (7) include the 7th support (701), the 7th motor (702), the 7th screw rod (703), the 7th nut set (704), discharge arm
(705), the 7th proximal end inductor (706), the 7th sensing chip (707), the 7th distal end inductor (708), spent reagent collection box
(709), the 7th screw rod (703) is driven the discharge arm (705), and the discharge arm (705) pushes spent reagent to give up to described
In reagent collection box (709), pass through the 7th proximal end inductor (706), the 7th sensing chip (707), the 7th distal end inductor
(708) location information of the discharge arm (705) is sensed, the 7th sensing chip (707) is arranged in the discharge arm (705)
On, the two holding position is consistent.
17. automatic lmunoassays analyzer as described in claim 1, it is characterised in that: further include assembly of the plunger pump (9), diaphragm
Pump assembly (10), the assembly of the plunger pump (9) include the 9th support (901), the 9th motor (902), plunger pump (903), pump into
Mouth (904), pump discharge (905), the 9th solenoid valve (906)；The bellows pumping element (10) includes the first support, diaphragm waste liquid
Pump, diaphragm liquid feeding pump, the first solenoid valve, second solenoid valve, according to setting program, system controls assembly of the plunger pump (9), diaphragm pump group
Part (10) and respective line, puncturing sampling probe quantitatively can draw or inject sample, buffer, cleaning solution between each position, also
It can suck and go out residual liquid in needle after air again, and waste liquid is made to inject waste liquid recovery apparatus.
18. a kind of detection method of the automatic lmunoassays analyzer as described in claim 1-17 any one, it is characterised in that:
(1) detection information is set, the reagent card that need to be detected is fixed in incubating device (4), a reagent card is fixed in every addition,
Incubating device (4) moves right a distance along straight line；
(2) sample information is added, sample is sampled by sampling assemble (5), the buffer of extraction is mixed well into processing
It is added in the reagent card of the incubating device (4) by sampling assemble (5) afterwards or directly；
(3) it is incubated for control, according to each reagent card temperature requirements, temperature is carried out by the temperature control electronic module in incubating device (4)
Degree control, and be incubated for according to the different reaction time；
(4) testing result information is fed back, and keeps reagent card motionless, and detection device (8) motion detection head (804) keeps reagent card
Stabilization, reach higher detection accuracy, the reagent card of incubation time as defined in reaching detected, and result is fed back to
System control device；
(5) discharging after the completion of detection, carries out discharging by device for discharging (7).
19. the detection method of automatic lmunoassays analyzer as claimed in claim 18, it is characterised in that: in the step (1)
It specifically includes: placing reagent card from reagent card conveying device (2) inlet, the second code reader (207) reads the reagent card placed
Information, and judge whether information correct, if incorrect, alert, if correctly, passing through reagent card and conveying
Device (2) conveys multiple reagents and snaps into feeding structure (3), and the feeding structure (3) successively pushes in the multiple reagent card
Each arrive the incubating device (4) fixation position；Or directly the reagent card detected will be needed to be manually inserted into described incubate
In the fixation position for educating device (4).
20. the detection method of automatic lmunoassays analyzer as claimed in claim 18, it is characterised in that: in the step (2)
Specifically include: the sampling assemble (5) can be according to program setting after direct sample automatic in sampling device (1) or automatic puncturing
It samples again, the sample of sampling is placed in and is mixed in cup (602), after every sub-sampling, by the puncture sampling probe of sampling assemble (5)
(513) be placed in Washing cup (610) and cleaned, until all sample extraction is completed, will mix the sample in cup (602) into
Row mixes, and then the sample of mixing is added in the reagent card of the incubating device (4) by puncture sampling probe (513) and is carried out
It is incubated for.
21. the detection method of automatic lmunoassays analyzer as claimed in claim 18, it is characterised in that: in the step (3)
Specifically include: the temperature control electronic module (410) is in the bottom of the incubation monitor station (409) of incubating device (4) to adjust reagent
It snapping at a temperature of demand, the detection device (8) receives system control device for the incubation time information of each reagent card,
Realize that intelligences combination successively efficiently detects.
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