CN105548132B - Automate rotating disc type fluorescence detector - Google Patents

Automate rotating disc type fluorescence detector Download PDF

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Publication number
CN105548132B
CN105548132B CN201610133831.5A CN201610133831A CN105548132B CN 105548132 B CN105548132 B CN 105548132B CN 201610133831 A CN201610133831 A CN 201610133831A CN 105548132 B CN105548132 B CN 105548132B
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card
reagent card
reagent
automatic
fixing piece
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CN105548132A (en
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王治才
张平
李军民
王平美
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00356Holding samples at elevated temperature (incubation)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00455Controlling humidity in analyser
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0439Rotary sample carriers, i.e. carousels
    • G01N2035/0443Rotary sample carriers, i.e. carousels for reagents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The present invention relates to automation rotating disc type fluorescence detector, including reagent card transmission device, Card Reader detection device, automatic card falling device and the automatic card feeding device adjacent to reagent card transmission device.The surface of the reagent card transmission device is equipped with reagent card fixing piece, receives the reagent card of automatic card feeding device input;The Card Reader detection device includes the optical system for testing box of the fluorescence intensity of detection reagent card and the barcode recognizer of identification bar code information;The automatic card feeding device includes pushing structure, and the pushing structure promotes reagent card to enter reagent card fixing piece.The present invention is by setting automatic card falling device and automatic card feeding device, realize the purpose of high-volume test agent card automatic measurement, it is put into reagent card to be measured one by one without testing staff, so as to save substantial amounts of manpower and materials, improves the accuracy of detection efficiency and measurement result.

Description

Automate rotating disc type fluorescence detector
Technical field
The present invention relates to medical detecting Instrument field, and in particular to be automation rotating disc type fluorescence detector.
Background technology
Dry type detection technique of fluorescence is a kind of using dry type fluorometric reagent card as carrier, passes through optical path, screen bar code recognizer The quick medical detection technique being applied in combination with test platform, its principle are that measured object is acted on detection reagent, during by one section Between reaction, form conjugate, which launches the transmitting fluorescence of special spectrum under specific wavelength excitation, should Transmitting light is related to measured object grade ratio, and by the test to launching photocathode, measured matter is qualitatively or quantitatively divided Analysis.Existing dry type fluorescence detector is mainly made of the test platform of optical path and placement dry type fluorometric reagent card, is detected Personnel need test agent card being put into test platform one by one.But if if having large batch of test agent card, it is put into one by one This mode of reagent card needs to expend substantial amounts of manpower and materials, and detection efficiency is low, and speed is slow, be easy to cause measurement result Error.
The content of the invention
In view of the above-mentioned problems, the object of the present invention is to provide one kind to automate rotating disc type fluorescence detector, solve related glimmering Optical detector needs to be put into the waste of the manpower and materials caused by reagent card one by one, and detection efficiency reduces, and measurement result is easily made Into the technical problem of error.
In order to solve the above technical problems, the technical solution adopted by the present invention is automation rotating disc type fluorescence detector, including Reagent card transmission device, Card Reader detection device, automatic card falling device and the automatic card feeding device adjacent to reagent card transmission device. The surface of the reagent card transmission device is equipped with reagent card fixing piece, receives the reagent card of automatic card feeding device input.The reading Card detection apparatus includes the optical system for testing box of the fluorescence intensity of detection reagent card and the barcode recognizer of identification bar code information. The automatic card feeding device includes pushing structure, and the pushing structure promotes reagent card to enter reagent card fixing piece.
The reagent card transmission device is reagent card carrier or transmission track.
The reagent card fixing piece is arranged at intervals in the surface of the reagent card transmission device, and the reagent card fixing piece Radially extend to the outer edge of reagent card transmission device, the reagent card fixing piece and be equipped with the opening for being used for placing reagent card Upward groove, receives the reagent card of automatic card feeding device transmission, and drives reagent card with the rotation of reagent card carrier and turn It is dynamic.
Preferably, the automatic card falling device include falling card slide plate, baffle plate, the load block tongue for loaded reagent card and For the moving guide rail with dynamic load block tongue, the optical system for testing box is arranged on same straight line with the baffle plate and load block tongue, institute State load block tongue and the optical system for testing box and baffle plate are passed sequentially through under the drive of moving guide rail, the side of the baffle plate is equipped with Fall card slide plate, reagent card is separated with load block tongue after being intercepted by baffle plate and slid with card slide plate is fallen.
Preferably, the upper horizontal of the reagent card carrier is equipped with installing plate, the Card Reader detection device and automatic Fall card device to be individually fixed on the installing plate, the Card Reader detection device is moved along the reagent card fastener length direction The fluorescence intensity of detection reagent card, the automatic card falling device is along reagent card fixing piece direction by reagent card from reagent card fixing piece Interior submitting.
Preferably, the both sides and one end of the reagent card fixing piece are equipped with locating piece, the center of the locating piece is set Be useful for location hole reagent card fixing piece being installed on the reagent card carrier.
Preferably, the reagent card fixing piece further includes shrapnel, the shrapnel is respectively arranged on the two sides of the groove, Fixating reagent card.
Preferably, the two sides of the groove are respectively bent inward to form baffle, prevent reagent card from moving up.
Preferably, the automatic card feeding device further includes fan-shaped installing plate and reagent card case, the fan-shaped installation Plate is connected with the outer edge of reagent card carrier, and is provided with the fan-shaped installing plate and multiple is used for fixating reagent card case Card slot, place multiple reagent cards vertically in the reagent card case;The pushing structure is arranged at the fan-shaped installing plate Bottom.
Preferably, the pushing structure includes pushing block, motor and the transmission belt for connecting motor, the side of pushing block passes through Spring is fixed, and the opposite opposite side of pushing block connects the transmission belt, and under the action of transmission belt, the pushing block drives reagent to stick into Enter the reagent card fixing piece, and set back under the pulling of spring.
Preferably, the top installation having heaters of the reagent card case, between two neighboring reagent card case It is provided with drier.
Preferably, the automatic card feeding device further includes shell, the surface of the shell is equipped with display test agent card The indicator light or display screen of quantity.
Beneficial effects of the present invention:
1st, it is automatic to realize high-volume test agent card by setting automatic card falling device and automatic card feeding device by the present invention Change the purpose of measurement, be put into reagent card to be measured one by one without testing staff, so as to save substantial amounts of manpower and materials, improve detection The accuracy of efficiency and measurement result.
The 2nd, automatic card falling device and the integration of Card Reader detection device can be reduced to the volume of fluorescence detector, two separate The step of merge into a step, accelerate detection speed, while reagent card is exited from reagent card and enters back into load block tongue, again The position of reagent card is secured, avoids reagent card that slight offset occurs when being rotated on reagent card carrier, causes Card Reader to be examined The information of reagent card can not be read exactly by surveying device, further improve the accuracy of detection.
3rd, the fixed structure that the present invention replaces the dry type fluorescence detector of routine using reeded reagent card fixing piece is set, So that reagent card is not easy to come off from reagent card carrier, so that reagent card carrier velocity of rotation can be further speeded up, carry High detection efficiency.
Brief description of the drawings
Invention is described further using attached drawing, but the embodiment in attached drawing does not form any limitation of the invention, For those of ordinary skill in the art, without creative efforts, it can also be obtained according to the following drawings Its attached drawing.
Fig. 1 is the structure diagram of the embodiment of the present invention one.
Fig. 2 is the decomposition texture schematic diagram of the embodiment of the present invention one.
Fig. 3 is the structure diagram of the reagent card fixing piece of the present invention
Fig. 4 is the structure diagram after the reagent card fixing piece loaded reagent card of the present invention.
Fig. 5 is the structure diagram of the automatic card falling device of the embodiment of the present invention three.
Fig. 6 is the structure diagram of four conveyor track of the embodiment of the present invention
Fig. 7 is the work flow diagram of the embodiment of the present invention four
Reference numeral:1st, reagent card carrier, 2, reagent card fixing piece, 3, automatic card feeding device, 4, reagent card case, 5th, fan-shaped installing plate, 6, motor, 7, transmission belt, 8, card slot, 9, automatic card falling device, 10, Card Reader detection device, 11, installing plate, 31st, reagent card, 32, shrapnel, 33, baffle, 34, groove, 41, locating piece, 42, positioning plate, 52, rail brackets, 53, optical system for testing Box, 55, fall card slide plate, 56, baffle plate, 57, carry block tongue, 58, moving guide rail, 59, notch, 61, conveyor track.
Embodiment
The invention will be further described with the following Examples.
Embodiment one
Automate rotating disc type fluorescence detector, including reagent card transmission device, Card Reader detection device 10, automatic card falling device 9 and the automatic card feeding device 3 adjacent to reagent card transmission device.
In the present embodiment, the reagent card transmission device is reagent card carrier.
As depicted in figs. 1 and 2, the surface of the reagent card carrier 1 is circumferentially spaced is equipped with the fixing of multiple reagents Determine part 2, the reagent card fixing piece 2 is radially extended to the excircle of reagent card carrier 1, facilitates reagent card fixing piece 2 Opening outwardly is docked with automatic card feeding device 3, avoids colliding when receiving reagent card 31 to be measured.
The Card Reader detection device 10 includes the optical system for testing box and identification bar code of the fluorescence intensity of detection reagent card 31 The barcode recognizer of information.In the present embodiment, the upper horizontal of the reagent card carrier 1 is equipped with installing plate 11, described Card Reader detection device 10 and automatic card falling device 9 are individually fixed on the installing plate 11, and the Card Reader detection device 10 is along institute State 2 length direction of reagent card fixing piece to move back and forth, the fluorescence intensity of detection reagent card 31, the automatic card falling device 9 is along examination The direction of agent card fixing piece 2 is sent out by reagent card 31 out of reagent card fixing piece 2.
As shown in Figure 3 and Figure 4, the reagent card fixing piece 2 is equipped with the recessed of the opening upwards for placing reagent card 31 Groove 34.Since reagent card 31 needs to rotate with reagent card carrier 1, reagent card 31 slides from groove 34 in order to prevent, recessed The width of groove 34 should match with reagent card 31.But in practical application, in order to pick and place 31 convenience of reagent card, reagent card 31 Width can be slightly less than the width of groove 34, therefore there are certain gap between groove 34 and reagent card 31 so that reagent card The 31 left and right offsets during rotation, cause the letter that fixed Card Reader detection device 10 can not accurately on reading reagent card 31 Breath, so as to cause error.In the present embodiment, as shown in figure 3, the reagent card fixing piece 2 further includes shrapnel 32, the shrapnel 32 are embedded in the two sides of the groove 34 and to 34 internal stretch of groove respectively, clamp reagent card 31, prevent reagent card 31 from Accurate fixating reagent card 31 while landing on reagent card fixing piece 2 so that Card Reader detection device 10 can accurate detection reagent card Information on 31.
In addition in the present embodiment, the two sides of the groove 34 are respectively bent inward to form baffle 33, the baffle 33 The top of reagent card 31 is covered in, is avoided due to vibrating or rotating and so that reagent card 31 comes off from top.The reagent card The both sides and one end of fixing piece 2 are equipped with locating piece 41, and the center of the locating piece 41, which is equipped with, to be used to pacify reagent card fixing piece 2 The location hole 42 being attached on the reagent card carrier 1, is installed with bolt in the location hole 42, reagent card fixing piece 2 is fixed In on reagent card carrier 1, so that reagent card fixing piece is integrated with reagent card carrier, both rotate at the same time.
In the present embodiment, the automatic card falling device 9 includes being moved radially by belt pulley drives edge reagent card fixing piece 2 Fall card device, it is described fall card device be provided with hook baffle, when falling card device and being located at initial position, the hook baffle is provided at reagent Card 31 lean on inner one end, when belt wheel drive falls the movement of card device, the hook baffle along the promotion reagent card 31 of reagent card fixing piece 2 to Depart from reagent card carrier 1.
In the present embodiment, the automatic card feeding device 3 includes pushing structure, fan-shaped installing plate 5 and reagent card case 4.The sector installing plate 5 is connected with the outer edge of reagent card carrier 1, and is provided with multiple use on the fan-shaped installing plate 5 In multiple reagent cards 31 are placed in the card slot 8 of fixating reagent card case 4, the reagent card case 4 vertically.It is described to promote knot Structure is arranged at the bottom of the fan-shaped installing plate 5, promotes the reagent card 31 of 4 bottommost of reagent card case to reagent card fixing piece 2 movements.In the present embodiment, the pushing structure include pushing block, motor 6 and connect motor 6 transmission belt 7, the one of pushing block The one end of card slot 8 away from reagent card carrier 1 is fixed in side by spring, and the opposite opposite side of pushing block connects the transmission belt 7. Transmission belt 7 operates under the action of motor 6, pulls the pushing block that reagent card 31 is pushed into the reagent card fixing piece 2, then Set back under the pulling of spring, prepare to promote next reagent card 31.
In the present embodiment, the top installation having heaters of the reagent card case 4, two neighboring reagent card case Drier is provided between 4, the humidity and temperature of reagent card case 4 is kept, avoids reagent card 31 to be measured due to humidity Excessive or temperature is excessive and changes, and influences the accuracy of test result.
Since the shell of general fluorescence detector is opaque, tester can not understand test agent card in time Quantity, so as to reduce testing efficiency.Therefore, in the present embodiment, the automatic card feeding device 3 further includes shell, described outer The surface of shell is equipped with the indicator light or display screen for showing 31 quantity of reagent card to be measured so that tester is fully understood by be measured Reagent card 31 quantity, reagent card 31 to be measured is replenished in time.
Embodiment two
In the present embodiment, it is wide with reagent card for circumferentially uniform intervals to be provided with multiple width for the reagent card fixing piece The adaptable separate slot of degree dials chuck, and the separate slot is radially extended to excircle, separate slot shape on reagent card carrier Into the card slot for placing reagent card.Described group of chuck is superimposed on the reagent card carrier, and the reagent card carrier Fixed, described group of chuck is rotated relative to reagent card carrier.
Embodiment three
In order to avoid causing test result error occur due to the gap between reagent card 31 and groove 34, will can read Card detection apparatus 10 and the integration of automatic card falling device 9, are detected again after reagent card 31 is taken out from groove 34.
In the present embodiment, as shown in figure 5, the automatic card falling device 9 is arranged at the side of reagent card carrier 1.Institute State automatic card falling device 9 include falling card slide plate 55, baffle plate 56, the load block tongue 57 for loaded reagent card and for band dynamic load card The moving guide rail 58 of tongue 57.The optical system for testing box 53 is arranged on same straight line with the baffle plate 56 and load block tongue 57.Reagent After reagent card in card fixing piece enters the load block tongue 57, the load block tongue 57 passes sequentially through under the drive of moving guide rail 58 The optical system for testing box 53 and baffle plate 56.The baffle plate 56 can be square or other shapes, and the baffle plate 56 surface is equipped with notch 59, and the area of the notch 59 is more than the cross-sectional area of described load 57 a side of block tongue, is mounted with When the baffle plate 56 of reagent card is by baffle plate 56, a side of block tongue 57 is carried by the notch 59, and is carried in block tongue 57 Reagent card is then intercepted by the baffle plate 56.The side of the baffle plate 56 is equipped with card slide plate 55, the reagent card after interception with Fall card slide plate 55 to slide.
Remaining is the same as embodiment one.
Example IV
In the present embodiment, as shown in fig. 6, the reagent card transmission device is transmission track 61.
The automatic card feeding device includes pushing structure, and the pushing structure is arranged on the side of transmission track 61 and docks examination Agent card fixing piece.
In use, the present embodiment workflow is:(1) sample (vacuum blood collection tube for being mounted with blood sample) and it is emitted on test tube After on frame, rack for test tube is shifted onto setting position automatically, mechanical arm takes first sample (vacuum blood collection tube) to be placed on first and specifies Position (test tube is put into position), carries out puncture sampling;(2) revolving cup (turntable) starts to act in, and middle revolving cup enters transfer with queue-type Cup placing groove;(3) needle aspirate buffer solution, buffer solution are put into middle revolving cup;(4) blood sample is put into middle revolving cup, revolving cup in mixing In liquid;(5) automatic card feeding device action, reagent card is placed on transmission track, and be transported to the second designated position and (add Sample position) sample-adding;(6) liquid in revolving cup, is added on the reagent card of sample-adding position in drawing, and carries the reagent card of sample, movement To the 3rd designated position (position to be tested), the action of optical system for testing box starts to test, and after test, reagent card moves to the 4th finger Positioning puts and (abandons screens), carries out falling card automatically.
Remaining is the same as embodiment one.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than the present invention is protected The limitation of scope is protected, although being explained with reference to preferred embodiment to the present invention, those of ordinary skill in the art should Work as understanding, can be to technical scheme technical scheme is modified or replaced equivalently, without departing from the reality of technical solution of the present invention Matter and scope.

Claims (9)

1. automate rotating disc type fluorescence detector, it is characterised in that including reagent card transmission device, Card Reader detection device, automatic Fall card device and the automatic card feeding device adjacent to reagent card transmission device;The surface of the reagent card transmission device is equipped with reagent Card fixing piece, receives the reagent card of automatic card feeding device input;The fluorescence that the Card Reader detection device includes detection reagent card is strong The optical system for testing box of degree and the barcode recognizer of identification bar code information;The automatic card feeding device includes pushing structure, institute Stating pushing structure promotes reagent card to enter reagent card fixing piece;The automatic card falling device includes falling card slide plate, baffle plate, is used for Loaded reagent card carries block tongue and for the moving guide rail with dynamic load block tongue, the optical system for testing box and the baffle plate and load card Tongue is arranged on same straight line, and the load block tongue passes sequentially through the optical system for testing box and baffle plate under the drive of moving guide rail, The side of the baffle plate is equipped with card slide plate, and reagent card is separated with load block tongue after being intercepted by baffle plate and slided with card slide plate is fallen Fall.
2. automation rotating disc type fluorescence detector according to claim 1, it is characterised in that the reagent card transmission device For reagent card carrier or transmission track.
3. it is according to claim 2 automation rotating disc type fluorescence detector, it is characterised in that the reagent card fixing piece in The surface of the reagent card transmission device is arranged at intervals, and the reagent card fixing piece is radially extended to reagent card transmission device Outer edge, the reagent card fixing piece be equipped be used for place reagent card opening upwards groove, receive automatically into clamping The reagent card of transmission is put, and drives reagent card to be rotated with the rotation of reagent card carrier.
4. the automation rotating disc type fluorescence detector according to Claims 2 or 3, it is characterised in that the reagent card carrying The upper horizontal of disk is equipped with installing plate, and the Card Reader detection device and automatic card falling device are individually fixed on the installing plate, The Card Reader detection device is moved with the fluorescence intensity of detection reagent card along the reagent card fastener length direction, described automatic Fall card device to send out out of reagent card fixing piece reagent card along reagent card fastener length direction.
5. automation rotating disc type fluorescence detector according to claim 3, it is characterised in that the reagent card fixing piece is also Including shrapnel, the shrapnel is respectively arranged on the two sides of the groove, fixating reagent card.
6. automation rotating disc type fluorescence detector according to claim 1, it is characterised in that the automatic card feeding device is also Including fan-shaped installing plate and reagent card case, the sector installing plate is connected with the outer edge of reagent card carrier, and described Multiple card slots for fixating reagent card case are provided with fan-shaped installing plate, vertical placement is more in the reagent card case A reagent card;The pushing structure is arranged at the bottom of the fan-shaped installing plate.
7. automation rotating disc type fluorescence detector according to claim 6, it is characterised in that the pushing structure includes pushing away Block, motor and the transmission belt for connecting motor, the side of pushing block are fixed by spring, and the opposite opposite side of pushing block connects the biography Dynamic band, under the action of transmission belt, the pushing block drives reagent card to enter the reagent card fixing piece, and under the pulling of spring Set back.
8. the automation rotating disc type fluorescence detector according to claim 6 or 7, it is characterised in that the reagent card storage Having heaters is installed on the top of box, and drier is provided between two neighboring reagent card case.
9. the automation rotating disc type fluorescence detector according to claim 6 or 7, it is characterised in that described automatically into clamping Put and further include shell, the surface of the shell is equipped with the indicator light or display screen of display test agent card quantity.
CN201610133831.5A 2015-11-23 2016-03-09 Automate rotating disc type fluorescence detector Active CN105548132B (en)

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CN2015108238309 2015-11-23
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