CN110724626B - Integrated detection device of biochip - Google Patents
Integrated detection device of biochip Download PDFInfo
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- CN110724626B CN110724626B CN201911109104.5A CN201911109104A CN110724626B CN 110724626 B CN110724626 B CN 110724626B CN 201911109104 A CN201911109104 A CN 201911109104A CN 110724626 B CN110724626 B CN 110724626B
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Abstract
The invention discloses an integrated detection device of a biochip, which comprises supporting legs, a bearing platform, a recovery sample slot plate, a sample slot plate to be detected, a standard card, a scanner, a transmission mechanism, detection equipment, a loading mechanism, temperature control equipment and an unloading mechanism. The invention has reasonable design, can finish the detection of dozens of standard cards in a sample slot plate to be detected in a short time, keeps light-tight in the sample detection process, and carries out detection data acquisition and transmission through the precision probe and the data acquisition and transmission module, thereby ensuring the detection speed and precision of the sample.
Description
Technical Field
The invention relates to an integrated detection device, in particular to an integrated detection device of a biochip, belonging to the field of automatic detection and analysis instruments of biological samples.
Background
Biochips, also known as DNA chips or gene chips, are crystals of DNA hybridization probe technology combined with semiconductor industry technology, in which a large number of probe molecules are immobilized on a support and then hybridized with DNA sample molecules with fluorescent labels, and the number and sequence information of the sample molecules is obtained by detecting the hybridization signal intensity of each probe molecule.
In the testing work, people often need carry out short-term test and analysis to the composition of some unknown samples, to the quick and accurate its composition of detection of a large amount of samples, traditional detection mode check-out time is long, work efficiency is low, work load is great, need many people cooperation to utilize professional instrument to accomplish usually, personnel have carelessness will influence the accuracy that detects a little simultaneously, need shift to next detecting instrument on, complex operation, lack the continuity of detection. Therefore, an integrated detection device of biochip is proposed to solve the above problems.
Disclosure of Invention
The present invention has been made to solve the above problems, and an object of the present invention is to provide an integrated biochip measuring apparatus.
The invention realizes the aim through the following technical scheme, and the integrated detection device for the biochip comprises detection equipment and a transmission mechanism, wherein the detection equipment is arranged in the middle position of the top surface of a bearing table, the surfaces of the bearing tables at the two sides of the detection equipment are respectively and vertically provided with a recovery sample slot plate and a sample slot plate to be detected, the surface of the bearing table at the front end of the bottom of the sample slot plate to be detected is provided with a scanner, and a plurality of standard cards are stacked in the sample slot plate to be detected;
the transmission mechanism is arranged on one side of the bearing platform and is arranged between the loading mechanism and the unloading mechanism, the loading mechanism is positioned at the bottom of the sample slot plate to be tested, and the unloading mechanism is positioned at the bottom of the recovered sample slot plate.
Preferably, the bar recess has been seted up on plummer top surface, and bar recess notch and the sample frid bottom port that awaits measuring, retrieve sample frid bottom port, scanner scanning port and check out test set bottom parallel and level in proper order, the landing leg is all installed to plummer bottom four corners department.
Preferably, temperature control equipment is installed to plummer bottom intermediate position, and temperature control equipment passes through the conductor wire and cushion heating equipment electric connection, cushion heating equipment's heating structure is located around the middle part in the bar recess.
Preferably, the loading structure of the loading mechanism and the unloading structure of the unloading mechanism are respectively located at two ends of the strip-shaped groove, and the loading mechanism and the unloading mechanism are both connected with the corresponding output structures of the transmission mechanism through the connecting structures.
Preferably, the detection equipment comprises a precision probe and a data acquisition and transmission module, and the precision probe is positioned at the top of the middle position in the strip-shaped groove.
Preferably, the sample slot plate to be tested is provided with a card ejection mechanism, and the standard card is placed on the corresponding structure of the loading mechanism through the card ejection mechanism.
The invention has the beneficial effects that:
1. this kind of biochip's integrated detection device reasonable in design can accomplish the detection of dozens of standard cards in the sample frid that awaits measuring in the short time, keeps the light-resistant among the sample testing process to detect data acquisition transmission through accurate probe and data acquisition transmission module, guaranteed the detection speed and the precision of sample.
2. The integrated detection device for the biological chips is reasonable in design, and chips to be detected can be stacked together through the card ejection mechanism, the loading mechanism, the transmission mechanism and the unloading mechanism and can be sequentially and continuously detected through the corresponding detection structures, so that the chips to be detected can be continuously loaded and conveyed, the detection continuity is ensured, and the working efficiency is improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.
FIG. 1 is a perspective view of the overall structure of the present invention;
FIG. 2 is a front view of the overall structure of the present invention;
FIG. 3 is a schematic structural diagram of a sample well plate to be tested according to the present invention;
FIG. 4 is a schematic diagram of a standard card structure according to the present invention
Fig. 5 is a schematic structural diagram of the transmission mechanism of the present invention.
In the figure: 1. landing leg, 2, plummer, 3, retrieve the sample frid, 4, the sample frid that awaits measuring, 5, standard card, 6, scanner, 7, drive mechanism, 8, check out test set, 9, loading mechanism, 10, temperature control equipment, 11, uninstallation mechanism.
Detailed Description
In order to make the objects, features and advantages of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the embodiments described below are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.
Referring to fig. 1-5, an integrated detection device for biochips comprises a detection device 8 and a transmission mechanism 7, wherein the detection device 8 is installed at the middle position of the top surface of a bearing table 2, the surfaces of the bearing table 2 at the two sides of the detection device 8 are respectively and vertically provided with a recovered sample slot plate 3 and a sample slot plate 4 to be detected, the surface of the bearing table 2 at the front end of the bottom of the sample slot plate 4 to be detected is provided with a scanner 6, and a plurality of standard cards 5 are stacked in the sample slot plate 4 to be detected;
The top surface of the bearing table 2 is provided with a strip-shaped groove, the notch of the strip-shaped groove is flush with the bottom port of the sample groove plate 4 to be detected, the bottom port of the recovered sample groove plate 3, the scanning port of the scanner 6 and the bottom of the detection device 8 in sequence, the four corners of the bottom of the bearing table 2 are provided with the supporting legs 1, and the strip-shaped groove is formed in the bearing table 2, so that the loaded standard card 5 can be conveniently unloaded from the mechanism 11; the middle position of the bottom of the bearing table 2 is provided with a temperature control device 10, the temperature control device 10 is electrically connected with a buffer heating device through a conducting wire, and a heating structure of the buffer heating device is positioned around the middle part in the strip-shaped groove, so that the temperature control heating detection of the corresponding standard card 5 is facilitated; the loading structure of the loading mechanism 9 and the unloading structure of the unloading mechanism 11 are respectively positioned at two ends in the strip-shaped groove, and the loading mechanism 9 and the unloading mechanism 11 are both connected with the corresponding output structure of the transmission mechanism 7 through the connecting structure, so that the functional effect of loading and unloading the corresponding standard card 5 is achieved; the detection equipment 8 comprises a precision probe and a data acquisition and transmission module, and the precision probe is positioned at the top of the middle position in the strip-shaped groove and is convenient for detecting the standard card 5 through the precision probe; the sample trough plate 4 to be tested is provided with a card ejection mechanism, the standard cards 5 are placed on the corresponding structure of the loading mechanism 9 through the card ejection mechanism, and the standard cards 5 stacked on the sample trough plate 4 to be tested can be sequentially placed on the corresponding structure of the loading mechanism one by one.
When the device is used, a plurality of samples are made into standard cards 5, the standard cards 5 can be stacked and placed in a sample slot plate 4 to be detected, the cards in the sample slot plate 4 to be detected can be sent to a specified position one by one through a loading mechanism 9, a transmission mechanism 7 and an ejection mechanism, the cards sequentially pass through a scanner 6 to be scanned, a buffer heating device, a detection device 8 and the like, the standard cards 5 are finally sent to a sample recovery slot plate 3 through the transmission mechanism 7 and an unloading mechanism 11, the detection time of the standard cards 5 can be finished within dozens of seconds, through flow operation, the detection of dozens of standard cards 5 in the sample slot plate 4 to be detected can be finished within a short time, the light shielding is kept in the sample detection process, and the detection device 8 comprises a precision probe and a data acquisition and transmission module, so that the detection speed and the precision of the samples are ensured.
It is well within the skill of those in the art to implement and protect the present invention without undue experimentation and without undue experimentation that the present invention is directed to software and process improvements.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (4)
1. An integrated detection device of biochip is characterized in that: the detection device comprises detection equipment (8) and a transmission mechanism (7), wherein the detection equipment (8) is installed in the middle position of the top surface of a bearing table (2), a recovery sample groove plate (3) and a sample groove plate (4) to be detected are respectively and vertically installed on the surfaces of the bearing table (2) on the two sides of the detection equipment (8), a scanner (6) is installed on the surface of the bearing table (2) at the front end of the bottom of the sample groove plate (4) to be detected, and a plurality of standard cards (5) are stacked in the sample groove plate (4) to be detected;
the transmission mechanism (7) is arranged on one side of the bearing table (2), the transmission mechanism (7) is arranged between the loading mechanism (9) and the unloading mechanism (11), the loading mechanism (9) is positioned at the bottom of the sample slot plate (4) to be tested, and the unloading mechanism (11) is positioned at the bottom of the sample recovery slot plate (3);
the top surface of the bearing table (2) is provided with a strip-shaped groove, the notch of the strip-shaped groove is flush with the bottom port of the sample groove plate (4) to be detected, the bottom port of the sample recovery groove plate (3), the scanning port of the scanner (6) and the bottom of the detection equipment (8) in sequence, and four corners of the bottom of the bearing table (2) are provided with supporting legs (1);
temperature control equipment (10) is installed to plummer (2) bottom intermediate position, and temperature control equipment (10) pass through conductor wire and buffer heating equipment electric connection, buffer heating equipment's heating structure is located around the middle part in the bar recess.
2. The integrated detecting device of biochip according to claim 1, wherein: the loading structure of the loading mechanism (9) and the unloading structure of the unloading mechanism (11) are respectively positioned at two ends in the strip-shaped groove, and the loading mechanism (9) and the unloading mechanism (11) are connected with the corresponding output structures of the transmission mechanism (7) through connecting structures.
3. The integrated detecting device of biochip according to claim 1, wherein: the detection device (8) comprises a precision probe and a data acquisition and transmission module, and the precision probe is positioned at the top of the middle position in the strip-shaped groove.
4. The integrated detecting device for biochip according to claim 1, wherein: the sample trough plate (4) to be tested is provided with a card ejection mechanism, and the standard card (5) is placed on the corresponding structure of the loading mechanism (9) through the card ejection mechanism.
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| CN201911109104.5A CN110724626B (en) | 2019-11-13 | 2019-11-13 | Integrated detection device of biochip |
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| CN201911109104.5A CN110724626B (en) | 2019-11-13 | 2019-11-13 | Integrated detection device of biochip |
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| CN110724626B true CN110724626B (en) | 2022-05-10 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112940920B (en) * | 2021-01-31 | 2023-04-07 | 新羿制造科技（北京）有限公司 | Biochip analyzer |
| CN113755647B (en) * | 2021-10-15 | 2023-08-22 | 无锡市人民医院 | Novel coronavirus rapid detection system |
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