CN207457261U - A kind of full-automatic fluorescence immune chromatography analytical equipment - Google Patents
A kind of full-automatic fluorescence immune chromatography analytical equipment Download PDFInfo
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- CN207457261U CN207457261U CN201721523532.9U CN201721523532U CN207457261U CN 207457261 U CN207457261 U CN 207457261U CN 201721523532 U CN201721523532 U CN 201721523532U CN 207457261 U CN207457261 U CN 207457261U
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Abstract
The utility model discloses a kind of full-automatic fluorescence immune chromatography analytical equipments, belong to detection technique field.The equipment includes reagent card box loading assembly, reagent card transmission component, robot assemblies, incubate component, detection components, sample loading assembly, consumptive material loading assembly, support baseboard and control system, the reagent card box loading assembly provides reagent card for reagent card transmission component, sample to be detected in sample loading assembly is added in the mixing plate in consumptive material loading assembly by robot assemblies, mixing is carried out with dilution, and the sample after mixing is added in reagent card, reagent card after sample-adding is pushed to by reagent card transmission component incubates component progress constant temperature chromatography reaction, it completes the reagent card after reaction and enters detection components completion detection.A kind of full-automatic fluorescence immune chromatography analytical equipment provided by the utility model avoids manually-operated interference, ensure that the reaction environment of constant temperature, improve detection efficiency and measuring accuracy, it can be achieved that the in-vitro diagnosis of full-automation in detection.
Description
Technical field
The utility model is related to the detection technique field of in-vitro diagnosis more particularly to a kind of full-automatic fluorescence immune chromatographies point
Desorption device.
Background technology
POCT, real-time test (point-of-care testing) are a branches of in-vitro diagnosis industry, existing in sampling
Field is analyzed at once, saves complex process program of the sample in laboratory inspection, and the one kind for quickly obtaining inspection result is new
Method.Most of diagnostic devices are all semi-automated analysis instrument currently on the market, and sample-adding and chromatography process are all manually outside equipment
Face is completed, and manually sample-adding makes detection efficiency very low first, next increases test error caused by artificial interference, in addition also very
It is difficult to guarantee the reaction environment of constant temperature.
Utility model content
The purpose of this utility model is that a kind of full-automatic fluorescence immune chromatography analytical equipment is proposed, to solve the prior art
Present in detection efficiency it is low, artificial interference generate test error, it is difficult to ensure that the technical issues of isothermal reaction environment.
To achieve the above object, the utility model takes following technical scheme：
A kind of full-automatic fluorescence immune chromatography analytical equipment, including reagent card box loading assembly, reagent card transmission component, machine
Tool arm component incubates component, detection components, sample loading assembly, consumptive material loading assembly, support baseboard and control system, described
Reagent card box loading assembly, reagent card transmission component, robot assemblies, incubation component, detection components, sample loading assembly and consumption
Material loading assembly is sequentially arranged on support baseboard, and reagent card box loading assembly provides reagent card, machine for reagent card transmission component
Tool arm component by the sample to be detected in sample loading assembly be added in the mixing plate in consumptive material loading assembly and dilution into
Row mixing, and the sample after mixing is added in reagent card, the reagent card after sample-adding is pushed to temperature by reagent card transmission component
It educates component and carries out constant temperature chromatography reaction, the reagent card after completion reaction enters detection components and completes detection.
Further, the reagent card box loading assembly includes reagent cartridge, reagent cartridge fixed frame and automatic card-loading machine
Structure, reagent cartridge fixed frame include cartridge door frame and the first fixed plate, and cartridge door frame and the first fixed plate are realized pair respectively
The left and right of reagent cartridge and front and rear /V, automatic card-loading mechanism include the first electric rotating machine, the first synchronizing wheel, the first synchronous belt and
Elastic pushing block, control system control the operating of the first electric rotating machine, drive the first synchronizing wheel, the first synchronous belt and elastic pushing block fortune
Dynamic, elastic pushing block from reagent cartridge is pushed into reagent card the position corresponding to reagent card transmission component；
The cartridge door frame is equipped with horn opening and protrusion；
The magnetic element to attract each other is equipped at first fixed plate and the corresponding position of reagent cartridge.
Further, the reagent card transmission component includes chute, the second electric rotating machine, the second synchronizing wheel, second together
Band, the first lead screw motor, sample-adding pushing block, channel slot and the first strainer are walked, control system controls the operating of the second electric rotating machine,
The second synchronizing wheel, the second synchronous belt and chute movement are driven, reagent card is transported to sample-adding position one end, sample-adding pushing block is first
Reagent card is shifted onto sample-adding position under the drive of lead screw motor to be loaded, the reagent card after sample-adding is pushed into incubation group by sample-adding pushing block
Position corresponding to part；
The chute both sides are equipped with left compression shrapnel and right compression shrapnel, and left compression shrapnel is equipped with flange, right compression bullet
Piece and left compression shrapnel are arranged symmetrically；
First strainer includes band wheel seat, adjusting block, the first screw rod and the first spiro rod support, is fixed on band wheel seat
There is the first spiro rod support, the first screw rod connects the first spiro rod support and adjusting block, pulley shaft is connected on adjusting block, on wheel seat
Equipped with the first open slot and the second open slot, pulley shaft is passed through in the first open slot and is fixed on adjusting block, the second opening
Slot passes through for screw and locks the relative position with wheel seat and adjusting block.
Further, the robot assemblies include X-axis, Y-axis and Z axis, and X-axis is along consumptive material loading assembly, sample loading group
Part and detection components are horizontally disposed, and Y-axis is located at consumptive material loading assembly and sample loading assembly top, and X-axis vertical connection, in X
It is moved on axis, Z axis and Y-axis vertical connection can move in Y-axis and vertical direction, and Z axis bottom is connected with suction nozzle pick-up, leads to
It crosses pneumatic device and provides power for sampling.
Further, the incubation component includes incubating slot, temperature control component, incubates pushing block mechanism, the 3rd electric rotating machine, the
Three synchronizing wheels, the 3rd synchronous belt and the second strainer, temperature control component, which is located at, to be incubated immediately below slot, ensures that reagent card is incubating slot
Upper progress thermostat layer analysis reaction, control system control the operating of the 3rd electric rotating machine, drive the 3rd synchronizing wheel, the 3rd synchronous belt and temperature
Pushing block mechanism kinematic is educated, pushing block mechanism is incubated and reagent card is pushed to exit progress constant temperature chromatography reaction from slot entrance is incubated
And it waits to be detected；
There are the first pressing plate and the second pressing plate in the incubation slot both sides, prevent reagent card from overturning during the motion, the first pressure
Plate is additionally operable to support winding displacement；
The temperature control component includes heating film, temperature control pinboard and temperature sensor, and heating film, which is close to, to be incubated below slot
It is heated, for heating film equipped with thermistor for overheating protection, temperature sensor embedment, which incubates, carries out temperature data in slot
Acquisition, temperature control pinboard connection heating film and control system；
The incubation pushing block mechanism includes pushing block, push plate, guide rod, linear bearing and compression spring, and linear bearing is mounted on pushing block
The inside, guide rod run through linear bearing, and for compression spring sleeve on guide rod, push plate is fixed on one end of guide rod；
Second strainer and the first strainer structure are similar, and size is different.
Further, the detection components include fluorescent scanning element, micro-adjusting mechanism, detection pushing block, detection upper plate, detection
Lower plate, the second lead screw motor and reagent card recovering mechanism, control system control the operating of the second lead screw motor, drive detection pushing block handle
Reagent card is moved to below fluorescent scanning element and is detected, and the reagent card for completing to detect falls into reagent card recovering mechanism and returned
It receives；
The micro-adjusting mechanism includes the 3rd screw rod, the 3rd spiro rod support, fluorescent scanning element fixed frame and latch segment, fluorescence
Scanning element is fixed on fluorescent scanning element fixed frame, and the 3rd spiro rod support is fixed on detection upper plate, the rotation of the 3rd screw rod
Turn to drive moving left and right for fluorescent scanning element fixed frame, latch segment is used to lock fluorescent scanning element fixed frame；
Detection shrapnel is fixed in the detection lower plate, detection shrapnel is equipped with flange；
The reagent card recovering mechanism includes convex block, circle wheel, swing component, elastic element, L shifting parts, driving lever, recycling push plate
And accumulator tank, the second lead screw motor drive convex block and detection pushing block to be synchronized with the movement, circle wheel is fixed on swing component, L shifting parts one
End is equipped with the first circular hole and diagonal cut joint, and for coaxially connected with swing component, the other end is equipped with the 3rd open slot, exists for driving lever
It is slided in it, middle part is equipped with the second circular hole, is used for and detects the flexible connection of lower plate, swing component is compared with L shifting parts
Initial bit can be returned to after being swung every time under the action of elastic element, L shifting parts are in mechanical position limitation to same side oscillation
Under the action of may only can return to initial bit, L shifting parts after being swung every time under the action of elastic element to same side oscillation
One end equipped with the 3rd open slot drives driving lever and recycling push plate movement；
The working face of the convex block is made of semi circular surface, arc surface and planarea.
Further, the sample loading assembly includes rack for test tube, limit guide rail, sample bottom plate, the second fixed plate, sample
Marking plate and information reading element, rack for test tube slide back and forth under the restriction of limit guide rail and sample bottom plate, the second fixed plate pair
Rack for test tube, which is stablized, to be fixed, and sample identification plate shows the position of rack for test tube, and information reading element reads sample information and is transferred to control
System processed；
The magnetic element to attract each other is equipped at the corresponding position of second fixed plate and rack for test tube front end；
The limit guide rail wherein one end is that have arc transition between tip and two straight lines；
The sample bottom plate is equipped with indicator light.
Further, the consumptive material loading assembly includes mixing plate, dilution bottle, suction nozzle frame, suction nozzle recycling box and desorption
Head hook, mixing plate, dilution bottle, suction nozzle frame and suction nozzle recycling box are located in consumptive material fixed plate, are equipped with and slide below consumptive material fixed plate
Rail can slide back and forth；
The mixing plate is equipped with arc gap.
Further, housing is further included, the housing is equipped with function window.
In above-mentioned technical proposal, full automatic fluorescence immune chromatography analysis is realized.Specifically, starting up, to be detected
Sample is put into sample loading assembly, by display screen to sample information editor to be detected after start to detect, mechanical arm group
Part X-axis, Y-axis, Z axis movement under complete to the pickup of disposable tip, draw sample and dilution to be detected and (wrap in the process
Include desorption head and take suction nozzle), mixing, reagent card box loading assembly passes to reagent card transmission component delivery of therapeutic agents card by reagent card
Reagent card is transmitted to by dynamic component is loaded position, and the sample after robot assemblies absorption mixing is moved to sample-adding position and drops in reagent card
On, disposable tip is returned in suction nozzle recycling box afterwards, the reagent card after sample-adding is pushed to temperature by reagent card transmission component
It educates component and carries out constant temperature chromatography reaction, the reagent card after completion reaction enters detection components and completes detection, and will detect what is obtained
Information parameter is conveyed to control system, so as to complete once full automatic fluorescence immune chromatography analysis.Therefore the full-automatic fluorescence
Immunochromatographiassays assays equipment can realize full-automatic in-vitro diagnosis, and manually-operated interference is avoided in detection, ensure that perseverance
The reaction environment of temperature, improves detection efficiency and measuring accuracy.
Description of the drawings
Fig. 1 is the structure diagram of the complete machine of the utility model；
Fig. 2 is the forward sight structure diagram of the reagent card box loading assembly of the utility model；
Fig. 3 is the structure schematic diagram of the reagent card box loading assembly of the utility model；
Fig. 4 is the structure diagram of the reagent card transmission component of the utility model；
Fig. 5 is the configuration schematic diagram of first strainer of the utility model；
Fig. 6 is the structure diagram of the robot assemblies of the utility model；
Fig. 7 is the structure diagram of the incubation component of the utility model；
Fig. 8 is the configuration schematic diagram for incubating pushing block mechanism of the utility model；
Fig. 9 is the structure diagram of the detection components of the utility model；
Figure 10 is the forward sight structure diagram of the reagent card recovering mechanism of the utility model；
Figure 11 is the present invention looks up structural representation of the reagent card recovering mechanism of the utility model；
Figure 12 is the structure diagram of the sample loading assembly of the utility model；
Figure 13 is the structure diagram of the consumptive material loading assembly of the utility model；
Figure 14 is the front structure schematic diagram of the housing of the utility model；
Figure 15 is the structure schematic diagram of the housing of the utility model；
Figure 16 is the workflow block diagram of the utility model.
In figure：1st, reagent card box loading assembly；2nd, reagent card transmission component；3rd, robot assemblies；4th, component is incubated；5th, examine
Survey component；6th, sample loading assembly；7th, consumptive material loading assembly；8th, support baseboard；9th, housing；11st, reagent cartridge；111st, reagent
Card；12nd, reagent cartridge fixed frame；121st, cartridge door frame；1211st, horn opening；1212nd, it is raised；122nd, the first fixed plate；
13rd, automatic card-loading mechanism；131st, the first electric rotating machine；132nd, the first synchronizing wheel；133rd, the first synchronous belt；134th, elastic pushing block；
21st, chute；211st, left compression shrapnel；212nd, right compression shrapnel；22nd, the second electric rotating machine；23rd, the second synchronizing wheel；24th, second
Synchronous belt；25th, the first strainer；251st, band wheel seat；2511st, the first open slot；2512nd, the second open slot；252nd, adjusting block；
253rd, the first spiro rod support；254th, the first screw rod；26th, channel slot；27th, it is loaded pushing block；28th, the first lead screw motor；31st, X-axis；
32nd, Z axis；321st, suction nozzle pick-up；33rd, Y-axis；41st, slot is incubated；411st, the first pressing plate；412nd, the second pressing plate；42nd, the second tensioning
Mechanism；43rd, temperature control component；44th, the 3rd electric rotating machine；45th, pushing block mechanism is incubated；451st, guide rod；452nd, pushing block；453rd, linear axis
It holds；454th, compression spring；455th, push plate；51st, fluorescent scanning element；52nd, the second lead screw motor；53rd, micro-adjusting mechanism；531st, the 3rd spiral shell
Bar；532nd, the 3rd spiro rod support；533rd, fluorescent scanning element fixed frame；54th, reagent card recovering mechanism；541st, push plate is recycled；
542nd, accumulator tank；543rd, driving lever；544th, convex block；545th, circle wheel；546th, swing component；547th, L shifting parts；5471st, the first circular hole；
5472nd, the second circular hole；5473rd, the 3rd open slot；55th, pushing block is detected；56th, lower plate is detected；57th, upper plate is detected；61st, rack for test tube；
62nd, the second fixed plate；621st, magnet；63rd, sample bottom plate；631st, indicator light；64th, limit guide rail；65th, sample identification plate；66th, believe
Cease reading element；71st, mixing plate；711st, arc gap；72nd, dilution bottle；73rd, suction nozzle recycling box；74th, suction nozzle frame；75th, desorption
Head hook；76th, slide；77th, consumptive material fixed plate；91st, printer installing port；92nd, display screen installation window；93rd, reagent card recovery port；
94th, power switch installation window；95th, consumptive material loads window；96th, the box-packed load window of reagent card；97th, serial ports installation window；98th, dissipate
Hot mouth.
Specific embodiment
Below in conjunction with the accompanying drawings, the utility model is described further：
As shown in Figure 1, a kind of full-automatic fluorescence immune chromatography analytical equipment, including reagent card box loading assembly 1, reagent card
Transmission component 2, robot assemblies 3 incubate component 4, detection components 5, sample loading assembly 6, consumptive material loading assembly 7, support bottom
Plate 8 and control system, the reagent card box loading assembly 1, reagent card transmission component 2, robot assemblies 3, incubation component 4, inspection
It surveys component 5, sample loading assembly 6 and consumptive material loading assembly 7 to be sequentially arranged on support baseboard 8, reagent card box loading assembly 1 is
Reagent card transmission component 2 provides reagent card, and the sample to be detected in sample loading assembly 6 is added to consumptive material by robot assemblies 3
In mixing plate in loading assembly 7 and dilution carries out mixing, and the sample after mixing is added in reagent card, reagent card
Reagent card after sample-adding is pushed to incubation component 4 and carries out constant temperature chromatography reaction by transmission component 2, is completed the reagent after reaction and is sticked into
Enter detection components 5 and complete detection.
As in Figure 2-4, the reagent card box loading assembly 1 include reagent cartridge 11, reagent cartridge fixed frame 12 and from
Dynamic chucking mechanism 13, reagent cartridge fixed frame 12 include cartridge door frame 121 and the first fixed plate 122,121 He of cartridge door frame
First fixed plate 122 realizes the left and right and front and rear /V to reagent cartridge 11 respectively, and automatic card-loading mechanism 13 includes the first rotation
Motor 131, the first synchronizing wheel 132, the first synchronous belt 133 and elastic pushing block 134, control system control the first electric rotating machine 131
Operating drives the first synchronizing wheel 132, the first synchronous belt 133 and elastic pushing block 134 to move, and elastic pushing block 134 is reagent card 111
The position corresponding to reagent card transmission component 2 is pushed into from reagent cartridge 11；
The cartridge door frame 121 is equipped with horn opening 1211 and protrusion 1212；
The magnetic element to attract each other is equipped at 11 corresponding position of first fixed plate 122 and reagent cartridge；
In the present embodiment, the horn opening 1211 on cartridge door frame 121 is convenient for the plug of reagent cartridge 11, and inclined-plane exists
Reagent cartridge 11 play the guiding role when being inserted into, and protrusion 1212 is used cooperatively with the shaft in reagent cartridge 11, can prevent reagent
Cartridge 11 is erroneously inserted, and has the function of mistake proofing；First fixed plate 122 and reagent cartridge are respectively equipped with magnet at 11 corresponding position
And iron block, when reagent cartridge 11 is horizontally inserted into, stabilization is rested in reagent cartridge fixed frame 12 under the action of suction, reagent card
111 promote from 11 bottom level of reagent cartridge in chute 21 under the thrust of elastic pushing block 134, and elastic 134 return of pushing block is simultaneously
Etc. it is pending next time push away card command.
As illustrated in figures 4-5, the reagent card transmission component 2 includes chute 21, the second electric rotating machine 22, the second synchronizing wheel
23rd, the second synchronous belt 24, the first lead screw motor 28, sample-adding pushing block 27,26 and first strainer 25 of channel slot, control system control
It makes the second electric rotating machine 22 to operate, the second synchronizing wheel 23, the second synchronous belt 24 and chute 21 is driven to move, reagent card 111
Sample-adding position one end is transported to, reagent card 111 is shifted onto sample-adding position under the drive of the first lead screw motor 28 and carried out by sample-adding pushing block 27
It is loaded, the reagent card 111 after sample-adding is pushed into the position incubated corresponding to component 4 by sample-adding pushing block 27；
21 both sides of chute are equipped with left compression shrapnel 211 and right compression shrapnel 212, and left compression shrapnel 211, which is equipped with, to be turned over
Side, right compression shrapnel 212 and left compression shrapnel 211 are arranged symmetrically, and are played the role of clamping and anti-canting to reagent card 111, are protected
The reliable sample-adding to reagent card 111 is demonstrate,proved；
First strainer 25 includes band wheel seat 251, adjusting block 252, the first screw rod 254 and the first spiro rod support
253, with the first spiro rod support 253 is fixed on wheel seat 251, the first screw rod 254 connects the first spiro rod support 253 and adjusting block
252, pulley shaft is connected on adjusting block 252, band wheel seat 251 is equipped with the first open slot 2511 and the second open slot 2512, band
Wheel shaft is passed through in the first open slot 2511 and is fixed on adjusting block 252, and the second open slot 2512 is passed through and locked for screw
The relative position of dead band wheel seat 251 and adjusting block 252 realizes band by the screw thread auxiliary driving of the first screw rod 254 and adjusting block 252
The variation of shaft position is taken turns, so as to fulfill the elastic of synchronous belt is adjusted.
As shown in fig. 6, the robot assemblies 3 include X-axis 31, Y-axis 33 and Z axis 32, X-axis is along consumptive material loading assembly 7, sample
This loading assembly 6 and detection components 5 are horizontally disposed, and Y-axis is located at 6 top of consumptive material loading assembly 7 and sample loading assembly, with X-axis
Vertical connection moves in X-axis, and Z axis and Y-axis vertical connection can move, Z axis bottom is connected with suction in Y-axis and vertical direction
Head pick-up 321 provides power by pneumatic device for sampling.
As Figure 7-8, the incubation component 4 includes incubating slot 41, temperature control component 43, incubates pushing block mechanism the 45, the 3rd
Electric rotating machine 44, the 3rd synchronizing wheel (not indicated in figure), the 3rd synchronous belt (not indicated in figure) and the second strainer 42, temperature control
Component 43, which is located at, to be incubated immediately below slot 41, ensures that reagent card 111 carries out thermostat layer analysis reaction, control system control on slot 41 is incubated
It makes the 3rd electric rotating machine 44 to operate, the 3rd synchronizing wheel, the 3rd synchronous belt and incubation pushing block mechanism 45 is driven to move, incubates block-pushing machine
Reagent card 111 is pushed to exit progress constant temperature chromatography reaction from incubation 41 entrance of slot and waited to be detected by structure 45；
There are the first pressing plate 411 and the second pressing plate 412 in 41 both sides of the incubation slot, prevent reagent card 111 during the motion
Overturning, the first pressing plate 411 are additionally operable to support winding displacement；
The temperature control component 43 includes heating film (not indicated in figure), temperature control pinboard (not indicated in figure) and temperature sensing
Device (does not indicate) in figure, and heating film is close to incubate to be heated below slot 41, and heating film is protected equipped with thermistor for overheating
Shield, temperature sensor embedment incubate the acquisition that temperature data is carried out in slot 41, temperature control pinboard connection heating film and control system；
The incubation pushing block mechanism 45 includes pushing block 452, push plate 455, guide rod 451, linear bearing 453 and compression spring 454, directly
Spool holds 453 and is mounted on 452 the inside of pushing block, and guide rod 451 runs through linear bearing 453, and compression spring 454 is sleeved on guide rod 451, push plate
455 are fixed on one end of guide rod 451；
Second strainer 42 is similar with 25 structure of the first strainer, and size is different；
In the present embodiment, heating film uses Resistant heating film, and totally three pieces, single-sided back-adhesive is pasted in the case where incubating slot 41
Side, the temperature sensor that three surfaces scribble heat-conducting silicone grease are embedded in distance and incubate at 41 upper surface 1-2mm of slot, are located at incubate respectively
Both ends and centre of slot 41, and spacing is consistent, temperature control pinboard are located at below heating film, connect heating film and control system and right
Heating film is fixed.
As shown in figure 9, the detection components 5 include fluorescent scanning element 51, micro-adjusting mechanism 53, detection pushing block 55, detection
Upper plate 57, detection lower plate 56, the second lead screw motor 52 and reagent card recovering mechanism 54, control system control the second lead screw motor 52
Operating drives detection pushing block 55 that reagent card 111 is moved to 51 lower section of fluorescent scanning element and is detected, completes the reagent of detection
Card 111 falls into reagent card recovering mechanism 54 and is recycled；
The micro-adjusting mechanism 53 includes the 3rd screw rod 531, the 3rd spiro rod support 532,533 and of fluorescent scanning element fixed frame
Latch segment (does not indicate) in figure, and fluorescent scanning element 51 is fixed on fluorescent scanning element fixed frame 533, the 3rd spiro rod support
532 are fixed on detection upper plate 57, and the rotation of the 3rd screw rod 531 drives moving left and right for fluorescent scanning element fixed frame 533, locks
Tight block is used to lock fluorescent scanning element fixed frame 533；
Detection shrapnel (not indicated in figure) is fixed in the detection lower plate 56, detection shrapnel is equipped with flange；
As shown in figs. 10-11, the reagent card recovering mechanism 54 includes convex block 544, circle wheel 545, swing component 546, elasticity
Element (not indicated in figure), L shifting parts 547, driving lever 543, recycling push plate 541 and accumulator tank 542, the second lead screw motor 52 drive
Convex block 544 and detection pushing block 55 are synchronized with the movement, and circle wheel 545 is fixed on swing component 546, and 547 one end of L shifting parts is equipped with the first circle
Hole 5471 and diagonal cut joint (not indicated in figure), for coaxially connected with swing component 546, the other end is equipped with the 3rd open slot
5473, it is slided for driving lever 543 in it, middle part is equipped with the second circular hole 5472, is used for and detects the activity of lower plate 56 even
It connects, swing component 546 may only be to same side oscillation, after being swung every time under the action of elastic element all compared with L shifting parts 547
Initial bit can be returned to, L shifting parts 547 may only be to same side oscillation, in the effect of elastic element under the action of mechanical position limitation
Initial bit can be returned to after lower swing every time, one end that L shifting parts 547 are equipped with the 3rd open slot 5473 drives driving lever 543 and returns
Push plate 541 is received to move；
The convex block 544 wherein end face is made of semi circular surface, arc surface and planarea；
In the present embodiment, convex block 544 is made of POM plastic, and wear-resisting and alleviation impact, circle wheel 545 is kept away using standard rolling bearing
To exempt from the simple sliding contact between convex block 544, extend the working life of part, elastic element uses torque spring, through
It on first wheel shaft and is stuck in diagonal cut joint, places angular contact ball bearing in the second circular hole 5472 of L shifting parts 547, pass through second
Wheel shaft is fixed in detection lower plate 56, the width dimensions of the 3rd open slot 5473 of 547 other end of L shifting parts than driving lever 543 outside
The big 1mm in footpath, length dimension be subject to meet recycling push plate 541 release stroke, detect lower plate 56 on detection shrapnel and detection
Pushing block 55 is positioned opposite, plays the role of clamping and anti-canting to reagent card 111 jointly, ensures that reagent card 111 smoothly passes inspection
Area is surveyed, the operating of the second lead screw motor 52 is driven in 111 detection process of reagent card, and the semi circular surface on convex block 544 connects with circle wheel 545
It touches, circle wheel 545 and swing component 546 rotate by a certain angle together around the first circular hole 5471, under the action of elastic element, wait convex
Block 544 is by rear, and swing component 546 and circle wheel 545 are returned to initial bit, and the reagent card 111 for completing detection drops in accumulator tank 542
In, during 52 antiport of the second lead screw motor returns initial bit, the planarea on convex block 544 is contacted with circle wheel 545, circle wheel
The 545 and drive L of swing component 546 shifting parts 547 rotate together around the second circular hole 5472, and the rotation of L shifting parts 547 drives the 3rd
Driving lever 543 in open slot 5473 moves along a straight line, and so as to which the recycling being connected on driving lever 543 push plate 541 be driven to move, will fall off
Reagent card 111 in accumulator tank 542 is released, while under the action of elastic element, waits convex blocks 544 by rear, and reagent card returns
It receives mechanism 54 and is returned to original state, wait recycling next time.
As shown in figs. 1 and 12, the sample loading assembly 6 include rack for test tube 61, limit guide rail 64, sample bottom plate 63,
Second fixed plate 62, sample identification plate 65 and information reading element 66, rack for test tube 61 is in limit guide rail 64 and sample bottom plate 63
It being slid back and forth under restriction, the second fixed plate 62, which stablizes rack for test tube 61, fixes, and sample identification plate 65 shows the position of rack for test tube 61,
Information reading element 66 reads sample information and is transferred to control system；
The magnetic element to attract each other is equipped at second fixed plate 62 position corresponding with 61 front end of rack for test tube；
The limit guide rail 64 wherein one end is that have arc transition between tip and two straight lines；
The sample bottom plate 63 is equipped with indicator light 631；
In the present embodiment, the second fixed plate 62 position corresponding with 61 front end of rack for test tube is separately installed with magnet 621 and iron
Block (does not indicate) in figure, and when rack for test tube 61 is horizontally inserted into, what can be stablized under the action of suction rests on sample bottom plate 63,
The wherein one end of limit guide rail 64 is that have arc transition between tip and two straight lines, can make 61 smooth insertion of rack for test tube, sample bottom
Indicator light 631 on plate 63 is used to indicate whether rack for test tube 61 is inserted in place, and 65 person of being conveniently operated of sample identification plate has a clear understanding of
The location of rack for test tube 61.
As shown in Fig. 1 and Figure 13, the consumptive material loading assembly 7 includes mixing plate 71, dilution bottle 72, suction nozzle frame 74, suction
Head recycling box 73 and desorption head hook 75, mixing plate 71, dilution bottle 72, suction nozzle frame 74 and suction nozzle recycling box 73 are fixed positioned at consumptive material
On plate 77,77 lower section of consumptive material fixed plate is equipped with slide 76, can slide back and forth；
The mixing plate 71 is equipped with arc gap 711；
In the present embodiment, the mixing plate 71 of two kinds of different sizes can be stored simultaneously, convenient for different detection projects dilution and
Mixing, the circular arc male cooperation on arc gap 711 and consumptive material fixed plate 77 on mixing plate 71 uses, to ensure two kinds of mixings
The correct placement of plate 71, desorption head hook 75 is located at the surface of suction nozzle recycling box 73, for removing the suction on suction nozzle pick-up 321
Head is simultaneously deposited into suction nozzle recycling box 73, and slide 76 can be drawn completely using three section slides convenient for consumptive material loading assembly 7
Go out, facilitate the replacement of consumptive material.
As shown in figs. 14-15, housing 9 is further included, the housing is equipped with function window；
In the present embodiment, housing 9 is fixed on support baseboard 8, and corresponding window is provided on housing 9, including
Printer installing port 91, for installing thermal printing, reagent card is box-packed to carry window 96, for the replacement of reagent cartridge 11, consumptive material
Window 95 is loaded, for replacement and the supplement of mixing plate 71, dilution bottle 72, suction nozzle frame 74 and suction nozzle recycling box 73, display screen
Window 92,111 recovery port 93 of reagent card, power switch installation window 94, power supply and various serial ports installation window 97, heat dissipation are installed
Mouth 98.
With reference to each figure, the workflow of the full-automatic fluorescence immune chromatography analytical equipment of the present embodiment is done further
Explanation：
Starting up, sample to be detected are put into sample loading assembly 6, by display screen to sample information editor to be detected
After start to detect, robot assemblies 3 X-axis, Y-axis, Z axis movement under complete to the pickup of disposable tip, draw and treat
Detection sample and dilution (in the process including desorption head and take suction nozzle) and mixing, reagent card box loading assembly 1 are passed to reagent card
Reagent card 111 is transmitted to sample-adding position by 2 delivery of therapeutic agents card 111 of dynamic component by reagent card transmission component 2, and robot assemblies 3 are drawn
Sample after mixing is moved to sample-adding position and drops on reagent card 111, and disposable tip is returned in suction nozzle recycling box 73 afterwards
In, the reagent card 111 after sample-adding is pushed to incubation component 4 and carries out constant temperature chromatography reaction by reagent card transmission component 2, completes reaction
Reagent card 111 afterwards completes detection into detection components 5, and the information parameter that detection is obtained is conveyed to control system, so as to
Complete once full automatic fluorescence immune chromatography analysis.Therefore the full-automatic fluorescence immune chromatography analytical equipment can be realized automatically
The in-vitro diagnosis of change avoids manually-operated interference in detection, ensure that the reaction environment of constant temperature, improve detection efficiency and
Measuring accuracy.
The foregoing is merely the preferable one embodiment of the utility model, structure is not limited to the above-mentioned shape enumerated
Shape, all any modification, equivalent and improvement made within the spirit and principle of the utility model etc. should be included in this
Within the protection domain of utility model.
Claims (9)
1. a kind of full-automatic fluorescence immune chromatography analytical equipment, including reagent card box loading assembly, reagent card transmission component, machinery
Arm component incubates component, detection components, sample loading assembly, consumptive material loading assembly, support baseboard and control system, feature
It is：The reagent card box loading assembly, reagent card transmission component, robot assemblies, incubation component, detection components, sample dress
It carries component and consumptive material loading assembly is sequentially arranged on support baseboard, reagent card box loading assembly provides for reagent card transmission component
Sample to be detected in sample loading assembly is added in the mixing plate in consumptive material loading assembly by reagent card, robot assemblies,
Mixing is carried out with dilution, and the sample after mixing is added in reagent card, reagent card transmission component is by the reagent after sample-adding
Card, which is pushed to, incubates component progress constant temperature chromatography reaction, completes the reagent card after reaction and enters detection components completion detection.
2. full-automatic fluorescence immune chromatography analytical equipment according to claim 1, it is characterised in that：The reagent card is box-packed
Carrying component includes reagent cartridge, reagent cartridge fixed frame and automatic card-loading mechanism, and reagent cartridge fixed frame includes cartridge door frame
With the first fixed plate, cartridge door frame and the first fixed plate realize left and right and the front and rear /V to reagent cartridge respectively, automatic to fill
Mechanism for card includes the first electric rotating machine, the first synchronizing wheel, the first synchronous belt and elastic pushing block, control system and controls the first electric rotating
Machine operates, and drives the first synchronizing wheel, the first synchronous belt and elastic pushing block movement, elastic pushing block that reagent card is pushed away from reagent cartridge
Enter to the position corresponding to reagent card transmission component；
The cartridge door frame is equipped with horn opening and protrusion；
The magnetic element to attract each other is equipped at first fixed plate and the corresponding position of reagent cartridge.
3. full-automatic fluorescence immune chromatography analytical equipment according to claim 1, it is characterised in that：The reagent card transmission
Component includes chute, the second electric rotating machine, the second synchronizing wheel, the second synchronous belt, the first lead screw motor, sample-adding pushing block, passage
Slot and the first strainer, control system control the operating of the second electric rotating machine, drive the second synchronizing wheel, the second synchronous belt and transport
Slot moves, and reagent card is transported to sample-adding position one end, sample-adding pushing block, which shifts reagent card onto under the drive of the first lead screw motor, to be added
Sample position is loaded, and the reagent card after sample-adding is pushed into the position incubated corresponding to component by sample-adding pushing block；
The chute both sides are equipped with left compression shrapnel and right compression shrapnel, and left compression shrapnel is equipped with flange, right compression shrapnel and
Left compression shrapnel is arranged symmetrically；
First strainer includes band wheel seat, adjusting block, the first screw rod and the first spiro rod support, and the is fixed on band wheel seat
One spiro rod support, the first screw rod connect the first spiro rod support and adjusting block, and pulley shaft is connected on adjusting block, and band wheel seat is equipped with
First open slot and the second open slot, pulley shaft are passed through in the first open slot and are fixed on adjusting block, and the second open slot is used
It is passed through in screw and locks the relative position with wheel seat and adjusting block.
4. full-automatic fluorescence immune chromatography analytical equipment according to claim 1, it is characterised in that：The robot assemblies
Including X-axis, Y-axis and Z axis, X-axis is horizontally disposed along consumptive material loading assembly, sample loading assembly and detection components, and Y-axis is located at consumptive material
Loading assembly and sample loading assembly top, with X-axis vertical connection, are moved in X-axis, Z axis and Y-axis vertical connection, can be in Y-axis
It is moved on vertical direction, Z axis bottom is connected with suction nozzle pick-up, and power is provided for sampling by pneumatic device.
5. full-automatic fluorescence immune chromatography analytical equipment according to claim 1, it is characterised in that：The incubation component bag
It includes and incubates slot, temperature control component, incubates pushing block mechanism, the 3rd electric rotating machine, the 3rd synchronizing wheel, the 3rd synchronous belt and the second tensioning device
Structure, temperature control component, which is located at, to be incubated immediately below slot, ensures that reagent card carries out thermostat layer analysis reaction, control system control on slot is incubated
3rd electric rotating machine operates, and drives the 3rd synchronizing wheel, the 3rd synchronous belt and incubates pushing block mechanism kinematic, incubates pushing block mechanism examination
Agent card is pushed to exit progress constant temperature chromatography reaction from incubation slot entrance and waits to be detected；
There are the first pressing plate and the second pressing plate in the incubation slot both sides, prevent reagent card from overturning during the motion, the first pressing plate is also
It is used to support winding displacement；
The temperature control component includes heating film, temperature control pinboard and temperature sensor, and heating film is close to incubate to be carried out below slot
Heating, for heating film equipped with thermistor for overheating protection, temperature sensor embedment incubates the acquisition that temperature data is carried out in slot,
Temperature control pinboard connects heating film and control system；
The incubation pushing block mechanism includes pushing block, push plate, guide rod, linear bearing and compression spring, and linear bearing is mounted on inside pushing block,
Guide rod runs through linear bearing, and for compression spring sleeve on guide rod, push plate is fixed on one end of guide rod；
Second strainer and the first strainer structure are similar, and size is different.
6. full-automatic fluorescence immune chromatography analytical equipment according to claim 1, it is characterised in that：The detection components bag
Include fluorescent scanning element, micro-adjusting mechanism, detection pushing block, detection upper plate, detection lower plate, the second lead screw motor and reagent card recycling machine
Structure, control system control the operating of the second lead screw motor, drive detection pushing block reagent card be moved to below fluorescent scanning element into
Row detection, the reagent card for completing to detect fall into reagent card recovering mechanism and are recycled；
The micro-adjusting mechanism includes the 3rd screw rod, the 3rd spiro rod support, fluorescent scanning element fixed frame and latch segment, fluorescent scanning
Element is fixed on fluorescent scanning element fixed frame, and the 3rd spiro rod support is fixed on detection upper plate, the rotation band of the 3rd screw rod
Dynamic fluorescent scanning element fixed frame moves left and right, and latch segment is used to lock fluorescent scanning element fixed frame；
Detection shrapnel is fixed in the detection lower plate, detection shrapnel is equipped with flange；
The reagent card recovering mechanism includes convex block, circle wheel, swing component, elastic element, L shifting parts, driving lever, recycling push plate and returns
Slot is received, the second lead screw motor drives convex block and detection pushing block to be synchronized with the movement, and circle wheel is fixed on swing component, and L shifting parts one end is set
There are the first circular hole and diagonal cut joint, for coaxially connected with swing component, the other end is equipped with the 3rd open slot, for driving lever in it
It slides, middle part is equipped with the second circular hole, is used for and detects the flexible connection of lower plate, swing component may only compared with L shifting parts
To same side oscillation, initial bit can be returned to after being swung every time under the action of elastic element, L shifting parts are in the work of mechanical position limitation
Initial bit may only can be returned to after being swung every time under the action of elastic element, L shifting parts are equipped with to same side oscillation under
One end of 3rd open slot drives driving lever and recycling push plate movement；
The working face of the convex block is made of semi circular surface, arc surface and planarea.
7. full-automatic fluorescence immune chromatography analytical equipment according to claim 1, it is characterised in that：The sample loading group
Part includes rack for test tube, limit guide rail, sample bottom plate, the second fixed plate, sample identification plate and information reading element, and rack for test tube is limiting
It is slid back and forth under the restriction of position guide rail and sample bottom plate, the second fixed plate, which stablizes rack for test tube, fixes, the display examination of sample identification plate
The position of pipe support, information reading element read sample information and are transferred to control system；
The magnetic element to attract each other is equipped at the corresponding position of second fixed plate and rack for test tube front end；
The limit guide rail wherein one end is that have arc transition between tip and two straight lines；
The sample bottom plate is equipped with indicator light.
8. full-automatic fluorescence immune chromatography analytical equipment according to claim 1, it is characterised in that：The consumptive material loading group
Part includes mixing plate, dilution bottle, suction nozzle frame, suction nozzle recycling box and desorption head hook, mixing plate, dilution bottle, suction nozzle frame and suction
Head recycling box is located in consumptive material fixed plate, and slide is equipped with below consumptive material fixed plate, can be slid back and forth；
The mixing plate is equipped with arc gap.
9. full-automatic fluorescence immune chromatography analytical equipment according to claim 1, it is characterised in that：Housing is further included, institute
Housing is stated equipped with function window.
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| CN201721523532.9U CN207457261U (en) | 2017-11-15 | 2017-11-15 | A kind of full-automatic fluorescence immune chromatography analytical equipment |
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| CN201721523532.9U CN207457261U (en) | 2017-11-15 | 2017-11-15 | A kind of full-automatic fluorescence immune chromatography analytical equipment |
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Address after: 102200 Beijing, Changping District super Road, building No. 37, No. 7 Patentee after: Beijing Lepu Diagnostic Technology Co., Ltd Address before: 102200 Beijing, Changping District super Road, building No. 37, No. 7 Patentee before: BEIJING LEPU MEDICAL TECHNOLOGY Co.,Ltd. |