CN112557678A - Full-automatic chromatographic analyzer - Google Patents
Full-automatic chromatographic analyzer Download PDFInfo
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- CN112557678A CN112557678A CN202011564890.0A CN202011564890A CN112557678A CN 112557678 A CN112557678 A CN 112557678A CN 202011564890 A CN202011564890 A CN 202011564890A CN 112557678 A CN112557678 A CN 112557678A
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 6
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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Abstract
The invention discloses a full-automatic chromatographic analyzer in the field of immunoassay equipment, which comprises a color developing solution loading mechanism, a blood collection tube spiral cover code scanning mechanism, a TIP head dismounting mechanism, a sample adding mechanism, a diluent adding mechanism, a mixing mechanism and a kit conveying mechanism, wherein the color developing solution loading mechanism is connected with the sample adding mechanism through a TIP head; the color development liquid loading mechanism, the blood collection tube rotary cover code scanning mechanism, the TIP head dismounting mechanism, the sample adding mechanism, the diluent adding mechanism, the mixing mechanism and the kit conveying mechanism are electrically connected with a central control computer, the color development liquid loading mechanism, the camera, the blood collection tube rotary cover code scanning mechanism, the TIP head dismounting mechanism and the sample adding mechanism are all located on the right side of the kit conveying mechanism, the central control computer and the diluent adding mechanism are all located on the left side of the kit conveying mechanism, and the mixing mechanism is located on the feeding conveying front side of the kit conveying mechanism. The invention can solve the problems that the prior immunochromatography analyzer can not realize full automation, and has more factors influencing the inspection efficiency and the accuracy of the inspection analysis result.
Description
Technical Field
The invention relates to the field of immunoassay equipment, in particular to a full-automatic chromatographic analyzer.
Background
In the field of biological medical treatment, immunoassay examination is often required, and the state of the immune system of a human body is examined and judged by sampling and analyzing various target proteins, blood sugar, cells and electrolytes in a blood sample to assist in determining a medical treatment scheme. The immunoassay usually includes fluorescence immunoassay, nano enzyme immunochromatography assay and the like, and the main analytical instrument is a chromatography analyzer. When the existing chromatographic analyzer is used, blood samples, developing solution, diluent and the like need to be prepared in advance, and the chromatographic analyzer does not have related functions. And the collection of blood sample mainly realizes through the vacuum test tube at present, when carrying out the inspection analysis after the sampling, need demolish the safety lid of vacuum test tube and just can acquire the blood sample alone, or adopt the acupuncture to extract blood sample to the temporary storage mechanism in, the analysis appearance is provided to rethread pipeline during the inspection, needs more preparation work before the inspection analysis, influences inspection analysis efficiency to need wash the pipeline at every turn and avoid causing sample cross contamination. The developing solution is usually prepared in an existing preparation mode to ensure the effectiveness of the developing solution, the solution A and the solution B are usually mixed, and the developing solution is also required to be prepared in advance and then infused into an analyzer for use, or is also required to be prepared in the analyzer and then infused through a pipeline for use, but either the complex operation of temporary preparation is required, or the process that the pipeline needs to be cleaned exists, and the using amount of the developing solution is not easy to control, so that the accuracy of the inspection and analysis result is influenced. Similarly, the use of diluent is also the conventional way to use a large amount of diluent in a container by infusion through a pipeline, and the problems of dosage control and pipeline cleaning exist. These problems all make the existing chromatographic analyzer actually only a semi-automatic conclusion analysis device, and cannot realize the full-automatic proceeding of the immune layer series analysis, still more manual preparation operations are needed, and there are more factors affecting the inspection efficiency and factors affecting the accuracy of the inspection analysis result.
Disclosure of Invention
The invention aims to provide a full-automatic chromatographic analyzer to solve the problems that the existing immunochromatographic analyzer cannot realize full automation, still needs more manual preparation operations, and has more factors influencing the inspection efficiency and the inspection analysis result accuracy.
In order to achieve the purpose, the basic technical scheme of the invention is as follows: a full-automatic chromatographic analyzer comprises a shell, wherein a display is arranged on the shell, a central control computer and a camera are arranged on a base in the shell, and a developing solution loading mechanism for triggering uniform mixing and loading of developing solution on a kit is also arranged on the base; the blood collection tube rotary cover code scanning mechanism is used for removing the safety cap of the vacuum blood collection tube and scanning the code of the bar code of the vacuum blood collection tube; the TIP head dismounting mechanism is used for dismounting and replacing the blood sample sucking TIP head; a sample adding mechanism for connecting the TIP head to add a blood sample into the kit; a diluent addition mechanism for adding a diluent to the kit; the blending mechanism is used for uniformly mixing the blood sample and the diluent in the kit; the kit conveying mechanism is used for conveying the kit to a corresponding position for adding blood samples, diluent and developing solution and taking pictures; the color development liquid loading mechanism, the blood collection tube rotary cover code scanning mechanism, the TIP head dismounting mechanism, the sample adding mechanism, the diluent adding mechanism, the mixing mechanism and the kit conveying mechanism are electrically connected with a central control computer, the color development liquid loading mechanism, the camera, the blood collection tube rotary cover code scanning mechanism, the TIP head dismounting mechanism and the sample adding mechanism are all located on the right side of the kit conveying mechanism, the central control computer and the diluent adding mechanism are all located on the left side of the kit conveying mechanism, and the mixing mechanism is located on the feeding conveying front side of the kit conveying mechanism.
The principle and the advantages of the scheme are as follows: during practical application, the shell provides protection for the internal structure and supports partial structures, the display is used for displaying action control interfaces and analysis and detection operation interfaces of all internal mechanisms, the camera is used for carrying out image acquisition on the conditions after reaction of samples in the kit, and the central control computer is used for controlling starting and stopping actions of all internal mechanisms and analyzing images acquired by the camera to obtain an inspection result. The developing solution loading mechanism is used for triggering the developing solution storage mechanism on the kit to release the developing solution stored on the kit, so that the sample can be dyed in the kit to facilitate observation and analysis. Heparin tube spiral cover sweeps a yard mechanism and can carry out the safety cover automatically to the vacuum heparin tube and get rid of to accomplish the bar code scanning simultaneously, need not carry out heparin tube preparation work alone. The TIP head disassembly and assembly mechanism can automatically and conveniently replace and clamp the TIP head for blood sampling, and avoids cross contamination caused by repeated use. The sample adding mechanism can automatically use the TIP head to quantitatively extract blood samples in the vacuum blood collection tube and move the blood samples to be injected into the kit, and the sampling is accurate and reliable. The diluent adding mechanism can automatically add quantitative diluent into the kit, so that the blood sample can be quickly reacted conveniently. The mixing mechanism can automatically mix the blood sample and the diluent in the kit and infuse the blood sample and the diluent into the reagent strip so as to be convenient for the camera to shoot and observe. The reagent kit conveying mechanism automatically moves the reagent kit loaded with the test paper strips and the color development liquid storage piece to a preset position, and the reagent kit conveying mechanism is positioned and matched with the diluent adding mechanism, the sample adding mechanism, the color development liquid loading mechanism, the blending mechanism and the camera, so that the reaction, the color development and the image shooting of the blood sample on the reagent kit can be conveniently completed by the actions of all the mechanisms. The functions of automatic operation of each mechanism, blood sample extraction, TIP head replacement and the like are realized by the control of the central control computer, only the kit needs to be inserted, the nano enzyme immunochromatographic analysis of the blood sample can be automatically completed by providing the vacuum blood collection tube, the TIP head and the diluent, the inside does not need independent color development liquid and a blood sample conveying pipeline, the pipeline cleaning time does not need to be waited in the process of checking and analyzing at every time, and the detection is more convenient and efficient. The full-automatic operation of the immunochromatographic analyzer is realized, manual preparation operation is greatly reduced, factors such as blood sample preparation and color developing solution configuration which affect the efficiency of inspection and analysis are greatly reduced, the efficiency is effectively improved, factors such as cross contamination and pipeline residual reagents which affect the accuracy of analysis results are avoided, the high efficiency and accuracy of immunochromatographic analysis are effectively guaranteed, and the problems that the existing immunochromatographic analyzer cannot realize full automation, still needs more manual preparation operation, and has more factors which affect the inspection efficiency and factors which affect the accuracy of the inspection and analysis results are solved.
Further, kit conveying mechanism includes parallel arrangement's step-by-step belt and slide bar, and sliding connection has the loading seat on the slide bar, and the loading seat is connected with step-by-step belt bolted connection, loads the seat upper end and offers the loading groove parallel with the slide bar, and it is protruding to be equipped with elastic joint on the inslot lateral wall of loading. The step-by-step belt can be adopted as preferred to move the loading seat fixed distance of loading the kit, guarantee that the kit moves the location accuracy, the slide bar provides the slip support to the loading seat, and the loading groove is as the direct loading structure of kit, extrudes the joint to the kit from the side through the joint arch on the inner wall, guarantees that the kit loads the removal process and stabilizes.
Further, the blood collection tube cap screwing and code scanning mechanism comprises a conveying belt, clamping plates are arranged on the left side and the right side of the conveying belt, racks are arranged on the lower portions, facing the side wall of the conveying belt, of the clamping plates, stepping stepped gears are arranged between the two racks, the racks are intermittently meshed with the stepping stepped gears, vertical positioning rollers are arranged above the clamping plates, levers are connected between the positioning rollers and the clamping plates, and springs connected with the shell are arranged on one sides, away from the conveying belt, of the positioning rollers; a sweeping head is arranged on the outer side of each lever and faces to the position between the two levers. Be used for carrying the vacuum test tube as preferred conveyer belt, splint are used for carrying on spacingly from the side to the vacuum test tube, avoid the vacuum test tube to empty, the registration roller is as the setting element of vacuum test tube and the trigger piece of splint action, the vacuum test tube removes and pushes away to carry out the centre gripping to the vacuum test tube through lever linkage splint to the registration roller department, step-by-step gear moves the rubbing vacuum test tube rotation as power input drive splint, the cooperation is swept the pier and is scanned discerned to the bar code of vacuum test tube surface paste, the spring is as the elastic support of registration roller, like this at the automatic triggering rotation of vacuum test tube transportation in-process, accomplish simultaneously and sweep the sign indicating number discernment, the action is high-efficient, and.
Further, step-by-step gear meshing has single tooth wheel, and single tooth wheel coaxial coupling has the actuating lever, is equipped with the chute of circumference on the actuating lever, and the conveyer belt top is equipped with the cutting ferrule, and the cutting ferrule is connected with branch, and the branch tip is equipped with bellied rubber snap ring on the inner wall of cutting ferrule lower part in inserting the chute, and the branch cover is established on vertical guide bar, and the guide bar is connected on the shell, and the cutting ferrule top is connected with the collection hose. The power of as preferred one-way gear as power transmission spare with step-by-step gear turns into the rotation of actuating lever, the chute turns into the lift of branch as the rotation of power conversion structure with the rotation of actuating lever, the guide bar carries out spacing direction to branch, guarantee stable vertical movement, the cutting ferrule is as the executive component who gets the lid, take off the safety cover cartridge clip of vacuum test tube through vertical lift process rubber snap ring, the collection hose is collected the safety cover that takes off, sweep the sign indicating number and carry out the operation of getting rid of safety cover in step when vacuum test tube like this, adopt same power input energy-conservation high-efficient, and adopt the body rotation, the mode of safety cover vertical movement, the body that the in-process splendid attire had the blood sample remains stable, effectively avoid the pouring of blood sample.
Further, the sample adds the mechanism and includes the slide rail, the slide rail is striden and is established and sweep the terminal top of sign indicating number mechanism conveyer belt at heparin tube spiral cover, sliding connection has the slide on the slide rail, the slide bottom mounting has the telescopic link, the telescopic link bottom mounting has the pipettor, the pipettor includes rotation post and fixed lid, integrated into one piece has the outer gear on the lateral wall of rotation post, the rotation toe portion is fixed with two vertical pipettes that run through the rotation post, two pipettes are with the axis symmetric distribution of rotation post, fixed lid rotates to be connected in the rotation post upper end, the intercommunication has the negative pressure pipe on the fixed lid, the negative pressure pipe intercommunication has the piston cylinder that is located the slide upper end, fixed. The pipette on the preferable rotating column is connected with the negative pressure pipe and the TIP head, negative pressure generated by the piston cylinder is transmitted to the TIP head through the negative pressure pipe and the pipette, the telescopic rod drives the vertical movement to complete the insertion or separation of the TIP head into or from the blood sampling pipe, the work can be alternately switched through the design of the two pipettes, the efficiency is improved, and the external gear serves as one of driving structures for switching the pipettes and can be matched with the assembly and disassembly actions of the TIP head.
Further, the first dismouting mechanism of TIP includes the chute feeder, the lift driving piece, flexible driving piece, step gear and spiral break away from the piece, chute feeder and the horizontal perpendicular distribution of flexible driving piece, flexible driving piece is fixed on lift driving piece top, there is the flitch with pay-off spring coupling in the chute feeder, flexible driving piece's end fixing has the material loading pole, C type groove has been seted up on the lateral wall of material loading pole orientation chute feeder, step gear adds the outer gear intermittent type meshing in the mechanism with the sample, the spiral breaks away from the piece and is located the terminal outside of the horizontal translation orbit of pipette in the mechanism. As the clean TIP head of preferred chute feeder splendid attire, the pay-off spring provides thrust and gives the flitch with TIP head propelling movement for the feed rod, single TIP head is changed in C type groove holding, the telescopic driving piece transversely moves the TIP head on the feed rod to the pipette below of switching use, the vertical removal of lift driving piece drive feed rod pushes up the TIP head on the pipette, step gear and the position of two pipettes of external gear cooperation drive rotation column rotation regulation, make the used TIP head follow the pipette and rotate the one side that deviates from the feed rod, the spiral breaks away from the piece and scrapes the TIP head from the pipette in the rotation process, and another pipette rotates the installation that can carry out clean TIP head above the feed rod simultaneously, can accomplish the installation and the dismantlement of TIP head by automatic high efficiency like this.
Further, mixing mechanism is equipped with the piston including sucking a section of thick bamboo and agitator in the suction section of thick bamboo, and the piston is connected with the suction driving piece, and a suction section of thick bamboo is equipped with the suction tube, and the suction tube sets up towards the removal orbit end of loading seat in the kit conveying mechanism, and the agitator includes the agitator disk, and the agitator disk upper end inlays and is equipped with magnet, and the agitator disk bottom is connected with agitator motor, and the agitator disk is located loading seat below. A suction section of thick bamboo forms the negative pressure through suction driving piece drive piston and aspirates diluent and blood sample to the mixing chamber of kit as preferred, drives magnet through agitator motor and rotates, draws the magnetic bead activity in the mixing chamber and pegs graft diluent and blood sample with the assay automatically in the back in the assay appearance is removed to the kit, and then can be convenient automatic completion sample mixing, guarantee that the inspection analysis result is accurate reliable.
Furthermore, the color developing solution adding mechanism comprises a vertical pressing driving piece, a pressing rod extending out of the upper portion of the loading seat is fixed to the top of the pressing driving piece, and a pressing head is arranged at the end of the pressing rod. As the kit with the developing solution storage part is preferably used in a matched manner, after the kit enters the analyzer, the pressing rod and the pressing head are driven by the pressing driving part to extrude the developing solution in the developing solution storage part, the developing solution is configured by arranging a pipeline in the analyzer without using the developing solution, the pipeline cleaning requirement does not exist after the detection and analysis, the detection and analysis efficiency is higher, and the accurate quantitative use of the developing solution is facilitated.
Further, the diluent adds the mechanism and includes the conveying pipe, and the conveying pipe is connected with the hopper, and a plurality of diluent packages are adorned to the splendid attire in the hopper, and the conveying pipe end is equipped with step-by-step board that turns over, and step-by-step board bottom integrated into one piece that turns over has the clamp plate. Can load the diluent package in batches like this through the hopper as preferring, the conveying pipe carries the diluent package to the kit diluent cistern top after the location, turns over the board single through step-by-step and provides a diluent package to can crush the broken discharge diluent of diluent package automatically through the clamp plate at the action in-process, the structure is succinct, uses automatic high-efficient.
Further, the diluent bag is a spherical plastic bag with diluent sealed inside. As the preferred mode that such diluent adopts the independent packing of ration, do not need traditional pipeline to carry the diluent that flows, it is more accurate to the quantity control of diluent, more is favorable to guaranteeing the accuracy of inspection analysis result.
Drawings
FIG. 1 is a top view of a base in an embodiment of the invention;
FIG. 2 is a schematic structural diagram of a color developing solution loading mechanism in an embodiment of the present invention;
FIG. 3 is a schematic diagram of the arrangement of the transport mechanism and the camera of the reagent kit according to the embodiment of the present invention;
FIG. 4 is a top view of the sample addition mechanism in cooperation with a TIP head disassembly and assembly mechanism in an embodiment of the present invention;
FIG. 5 is a front view of FIG. 4 without the drive belt and feed chute;
fig. 6 is a longitudinal sectional view of a pipette in an embodiment of the present invention;
FIG. 7 is a schematic structural view of a cover-rotating code-scanning mechanism of a blood collection tube according to an embodiment of the present invention;
FIG. 8 is a schematic view of the cap-rotating code-scanning mechanism of the blood collection tube according to the embodiment of the present invention;
FIG. 9 is a cross-sectional view of a withdrawal barrel of the homogenizing mechanism in an embodiment of the present invention;
FIG. 10 is a schematic structural view of a mixer of the kneading mechanism in the embodiment of the present invention;
FIG. 11 is a schematic structural diagram of a diluent adding mechanism according to an embodiment of the present invention;
FIG. 12 is a schematic view of a reagent cartridge in an embodiment of the present invention;
FIG. 13 is a cross-sectional view A-A of FIG. 12;
FIG. 14 is a cross-sectional view taken along line B-B of FIG. 12;
FIG. 15 is an enlarged partial view taken at A in FIG. 13;
fig. 16 is a partial enlarged view at B in fig. 13.
Detailed Description
The following is further detailed by way of specific embodiments:
reference numerals in the drawings of the specification include: base 1, developing solution loading mechanism 2, camera 3, sample adding mechanism 4, sampling tube cap screwing and code scanning mechanism 5, TIP head disassembling and assembling mechanism 6, mixing mechanism 7, diluent adding mechanism 8, central control computer 9, kit conveying mechanism 10, reagent cartridge 11, vacuum blood sampling tube 22, safety cap 33, stepping belt 101, slide bar 102, loading seat 103, loading groove 104, pressing driving piece 201, pressing bar 202, pressing head 203, slide rail 401, slide seat 402, piston cylinder 403, negative pressure tube 404, driving telescopic piece 405, fixing cap 406, external gear 407, pipette 408, driving belt 409, spacing ring 410, buckling edge 411, stepping stepped gear 501, one-way gear 502, rack 503, push bar 504, rubber layer 505, driving rod 506, conveying plate 507, chute 508, support rod 509, guide rod 510, collecting hose 511, rubber clamping ring 512, clamping sleeve 513, spring 514, positioning roller 515, positioning roller, Mounting frame 516, lever 517, clamping plate 518, sliding groove 519, sliding block 520, pushing block 521, conveying belt 522, lifting driving piece 601, telescopic driving piece 602, feeding rod 603, C-shaped groove 604, baffle 605, stepping gear 606, collision switch 607, spiral separation sheet 608, feeding groove 609, feeding plate 610, feeding spring 611, suction barrel 701, suction pipe 702, suction driving piece 703, stirring disc 704, magnet 705, stirring motor 706, hopper 801, feeding pipe 802, stepping turning plate 803, pressing plate 804, dilution liquid tank 1101, sample tank 1102, fixing groove 1103, puncture sleeve 1104, storage bottle 1105, puncture rod 1106, pneumatic pipe 1107, mixing cavity 1108, mixing bag 1109, magnetic bead 1110, boss 1111, first aluminum film 1112, second aluminum film 1113, spike 1114, first pipeline 1115, waste liquid tank 1116 and second pipeline 1117.
The embodiment is basically as shown in the attached figure 1: a full-automatic chromatographic analyzer comprises a shell, a display is arranged on the shell, and a central control computer 9 and a camera 3 are arranged on a base 1 in the shell. The base 1 is also provided with a reagent box conveying mechanism 10 which is used for conveying the reagent box to a corresponding position for adding blood samples, diluent and developing solution and taking pictures, and the reagent box conveying mechanism 10 is positioned in the middle of the base 1. Referring to fig. 3, the reagent cartridge conveying mechanism 10 includes a stepping belt 101 and a sliding rod 102 which are arranged in parallel, the sliding rod 102 is connected with a loading seat 103 in a sliding manner, the loading seat 103 is connected with the stepping belt 101 through a bolt, a loading groove 104 which is parallel to the sliding rod 102 is formed in the loading seat 103, and an elastic clamping protrusion is arranged on the inner side wall of the loading groove 104. The right side of the kit conveying mechanism 10 is sequentially provided with a color development liquid loading mechanism 2, a camera 3, a sample adding mechanism 4, a blood collection tube spiral cover code scanning mechanism 5 and a TIPTIP head disassembling and assembling mechanism 6, the left side of the kit conveying mechanism 10 is sequentially provided with a central control computer 9 and a diluent adding mechanism 8, and the feeding conveying front side of the kit conveying mechanism 10 is provided with a uniformly mixing mechanism 7.
As shown in fig. 2, the developing solution loading mechanism 2 is configured to uniformly load the developing solution stored in the kit; the color developing solution adding mechanism comprises a vertical pressing driving piece 201, a pressing rod 202 extending out of the loading seat 103 is fixed at the top of the pressing driving piece 201, and a pressing head 203 is arranged at the end of the pressing rod 202.
Referring to fig. 4 and 5, the sample adding mechanism 4 is used to connect a TIP head to add a blood sample to the kit. Mechanism 4 includes slide rail 401, and slide rail 401 strides and establishes in the terminal top of 5 conveyer belts 522 of heparin tube spiral cover code scanning mechanism, and slide rail 401 outside parallel is equipped with step motor driven drive belt 409, and sliding connection has slide 402 on the slide rail 401, slide 402 and drive belt 409 bolted connection, and slide 402 bottom bolted fixation has drive extensible member 405, and drive extensible member 405 bottom mounting has the pipettor. As shown in fig. 6, the pipettor includes a rotating column and a fixed cover 406, an external gear 407 is integrally formed on an outer side wall of the rotating column, two pipettes 408 vertically penetrating through the rotating column are integrally formed at a bottom of the rotating column, and the two pipettes 408 are symmetrically distributed along an axis of the rotating column. The fixed cover 406 is rotatably connected to the upper end of the rotating column, the lower end of the fixed cover 406 is folded inwards to form a limiting ring 410, the top end of the rotating column is folded outwards to form a buckling edge 411, the buckling edge 411 is buckled on the limiting ring 410, the fixed cover 406 is communicated with a negative pressure pipe 404, the negative pressure pipe 404 is single, and the opening at the bottom end of the negative pressure pipe 404 is flush with the bottom end of the fixed cover 406. The negative pressure pipe 404 is connected to a piston cylinder 403 at the upper end of the slide 402, and a fixed cap 406 is welded to the driving telescopic member 405.
The blood collection tube cap-rotating code-scanning mechanism 5 is used for removing the safety cap of the vacuum blood collection tube 22 and scanning the code of the bar code pasted on the surface of the vacuum blood collection tube 22. Referring to fig. 7 and 8, the blood collection tube cap-rotating code-scanning mechanism 5 includes a conveying belt 522, the conveying belt 522 is perpendicular to the slide rail 401 of the sample adding mechanism 4, the conveying belt 522 is driven by a stepping motor, a plurality of side-by-side conveying plates 507 are provided on a belt surface of the conveying belt 522, and the evacuated blood collection tube 22 is pushed and advanced between adjacent conveying plates 507. Clamping plates 518 are arranged on the left side and the right side of the conveying belt 522, a rubber layer 505 is bonded on the upper portion of the side wall of the clamping plates 518 facing the conveying belt 522, racks 503 are integrally formed on the lower portion of the side wall of the clamping plates 518, a stepping stepped gear 501 is arranged between the racks 503 on the two clamping plates 518, and the racks 503 are in intermittent meshing with upper side teeth of the stepping stepped gear 501. A vertical positioning roller 515 is arranged above the clamping plate 518, the positioning roller 515 is mounted on a mounting frame 516 through a rotating shaft, and a spring 514 connected with the shell is arranged on one side of the mounting frame 516, which is far away from the conveying belt 522. Be connected with lever 517 between mounting bracket 516 and the splint 518, TC type groove 604 has been seted up along direction of delivery to one side that splint 518 deviates from conveyer belt 522, has slided ejector pad 521 in the TC type groove 604, and ejector pad 521 is connected with push rod 504, and the both ends of lever 517 have all been processed spout 519, have slided block 520 in the spout 519, and mounting bracket 516 and push rod 504 are articulated with the slider 520 at lever 517 both ends respectively. The outside of lever 517 is equipped with sweeps the pier, sweeps the pier and sets up towards between two levers 517. The lower side teeth of the step gear 501 are engaged with a one-way gear 502, the transmission ratio is 1, and the one-way gear 502 is a gear connected to the rotating shaft through a one-way bearing. The one-way gear 502 is coaxially connected with a driving rod 506, and a circumferential inclined groove 508 is formed on the upper surface of the driving rod 506. A clamping sleeve 513 is arranged above the conveying belt 522, a supporting rod 509 is welded at the side end of the clamping sleeve 513, the end of the supporting rod 509 is connected with a bearing inserted into the chute 508, a raised rubber snap ring 512 is arranged on the inner wall of the lower portion of the clamping sleeve 513, and the rubber snap ring 512 forms a necking structure. The middle part of the supporting rod 509 is sleeved on a vertical guide rod 510, the guide rod 510 is vertically connected to the shell, and the top of the clamping sleeve 513 is sleeved with a collecting hose 511.
The TIPTIP head assembling and disassembling mechanism 6 is used for assembling and disassembling the TIP head used for replacing blood sample suction. Referring to fig. 4 and 5, the TIPTIP head dismounting mechanism 6 includes a feeding chute 609, a lifting driving member 601, a telescopic driving member 602, a stepping gear 606 and a spiral releasing piece 608, the feeding chute 609 and the telescopic driving member 602 are transversely and vertically distributed, a feeding plate 610 is connected in the feeding chute 609 by a feeding spring 611, and the clean TIP heads are all placed in the feeding chute 609 and are pushed to the feeding rod 603 by the feeding plate 610 under the action of the feeding spring 611. The telescopic driving piece 602 is fixed at the top end of the lifting driving piece 601, a feeding rod 603 is welded at the end of the telescopic driving piece 602, the feeding rod 603 is a rectangular rod, a C-shaped groove 604 is formed in the side wall, facing the feeding groove 609, of the feeding rod 603, and a baffle 605 is integrally formed at the bottom of the feeding rod 603, on one side, close to the telescopic driving piece 602, of the C-shaped groove 604. The step gear 606 is intermittently engaged with the external gear 407 in the sample addition mechanism 4, an impact switch 607 is connected in series in a power supply circuit of the step gear 606, the impact switch 607 is positioned above the step gear 606 and is provided at the end of the translation track of the fixed cover 406 in the sample addition mechanism 4, and the spiral disengaging piece 608 is positioned outside the end of the transverse translation track of the pipette 408 in the sample addition mechanism 4.
The blending mechanism 7 is used for uniformly mixing the blood sample in the kit with the diluent; as shown in fig. 9, the blending mechanism 7 includes a suction tube 701 and a stirrer, a piston is disposed in the suction tube 701, the piston is connected to a suction driving member 703, a suction tube 702 is integrally formed at an end of the suction tube 701, the suction tube 702 is disposed toward an end of a moving track of the loading seat 103 in the reagent cartridge conveying mechanism 10, as shown in fig. 10, the stirrer includes a stirring plate 704, a magnet 705 is embedded at an upper end of the stirring plate 704, a stirring motor 706 is connected to a bottom of the stirring plate 704, and the stirring plate 704 is located below the loading seat 103.
A diluent adding mechanism 8 for adding a diluent to the reagent cartridge; referring to fig. 11, the diluent adding mechanism 8 includes a feeding pipe 802, the feeding pipe 802 is connected to a feeding hopper 801, a plurality of diluent bags are contained in the feeding hopper 801, a stepping turning plate 803 is provided at the end of the feeding pipe 802, and a pressing plate 804 is integrally formed at the bottom of the stepping turning plate 803. The step turning plate 803 is a turning plate hinged on the upper edge of the tail end of the feeding pipe 802, the hinged shaft is connected with a step motor, the pressing plate 804 is integrally formed at the bottom end of the turning plate, and the pressing plate 804 is arranged in a downward inclination mode. The diluent bag is a spherical plastic bag with diluent sealed inside.
The color development liquid loading mechanism 2, the blood collection tube cap-screwing code-scanning mechanism 5, the TIPTIP head dismounting mechanism 6, the sample adding mechanism 4, the diluent adding mechanism 8, the blending mechanism 7 and the kit conveying mechanism 10 are all electrically connected with a central control computer 9.
In this embodiment, a nanoenzyme chromatography reagent cartridge 11 is used in combination with fig. 12 and 13, and includes a cartridge body and a fixing groove 1103 formed in the cartridge body near the top, wherein a chromatography test paper for nanoenzyme chromatography detection is clamped in the fixing groove 1103; meanwhile, a dilution liquid tank 1101, a sample tank 1102 and a mixing cavity 1108 are arranged on the cartridge body close to the left side, an elastic mixing bag 1109 is arranged in the mixing cavity 1108, and communication pipelines are arranged between the mixing bag 1109 and the dilution liquid tank 1101, between the sample tank 1102 and the fixing groove 1103. The cartridge body is internally provided with a driving mechanism for driving the directional flow between the mixing chamber 1108 and the dilution liquid tank 1101, the sample tank 1102 and the fixing groove 1103. With reference to fig. 13 and 15, the driving mechanism includes an air pressure tube 1107, a first one-way valve, a second one-way valve, and a third one-way valve, a left port of the air pressure tube 1107 is disposed on a left side wall of the cartridge body, and a right port of the air pressure tube 1107 is disposed on a right side wall of the mixing chamber 1108. The first one-way valve is arranged on a communication pipeline between the dilution liquid tank 1101 and the mixing cavity 1108, so that the liquid in the dilution liquid tank 1101 can only flow to the mixing bag 1109 from the dilution liquid tank 1101; the second one-way valve is arranged on a communication pipeline between the mixing capsule 1109 and the sample tank 1102, so that the liquid in the sample tank 1102 can only flow to the mixing capsule 1109 from the sample tank 1102; the third check valve is disposed on a communication pipe between the mixing capsule 1109 and the fixing groove 1103, so that the liquid in the mixing capsule 1109 can flow only from the mixing capsule 1109 to the fixing groove 1103.
With reference to fig. 12 and 14, a waste liquid tank 1116 is formed in the cartridge body near the bottom of the left side, a first overflow hole is formed in the side wall of the dilution liquid tank 1101, and a first pipeline 1115 is communicated between the first overflow hole and the waste liquid tank 1116; a second overflow hole is formed in the side wall of the sample tank 1102, and a second pipeline 1117 is communicated between the second overflow hole and the waste liquid tank 1116. As shown in fig. 15, a mixing mechanism is disposed in the mixing capsule 1109, the mixing mechanism includes magnetic beads 1110 moving in the mixing chamber 1108, and under the action of an external magnetic field that constantly changes direction, the magnetic beads 1110 can move back and forth in the mixing capsule 1109 to mix the liquid in the mixing capsule 1109. A puncture rod 1106 for puncturing a diluent bag is arranged in the diluent tank 1101, the top of the puncture rod 1106 is in a pointed cone shape, and the top of the puncture rod 1106 is in contact with the diluent bag.
As shown in fig. 12, the cartridge body is detachably connected with a storage mechanism for storing the liquid a and the liquid B and preparing the color developing solution, and the cartridge body is provided with a drainage mechanism for draining the color developing solution in the storage mechanism into the color developing window. Referring to fig. 13 and 16, the drainage mechanism includes a circular boss 1111 integrally formed at the top of the cartridge body near the right end, and a communicating cavity for communicating the inner hole of the boss 1111 with the fixing groove 1103 is formed in the cartridge body. As shown in fig. 16, the storage mechanism includes a storage bottle 1105 and a puncturing sleeve 1104 screwed to the top of the storage bottle 1105, the bottom end of the storage bottle 1105 is inserted into the cartridge body, four insertion plates are integrally formed at the bottom of the storage bottle 1105 and annularly distributed, four rib plates are integrally formed in the inner hole of the boss 1111, and the top ends of the rib plates are provided with spikes 1114. A liquid A storage cavity and a liquid B storage cavity which are used for separately storing liquid A and liquid B are arranged in the storage bottle 1105, the liquid B storage cavity and the liquid A storage cavity are coaxially arranged, the liquid B storage cavity is positioned in the liquid A storage cavity, a communication hole communicated with the liquid A storage cavity is formed in the bottom of the liquid B storage cavity, a first sealing element is arranged on the communication hole, and the first sealing element comprises a first aluminum film 1112 bonded on the communication hole; the puncture sleeve 1104 is integrally formed with a first spike 1114 for puncturing the first aluminum film 1112, the bottom end of the storage bottle 1105 is provided with a drainage hole communicated with the liquid A storage cavity, and the bottom end of the drainage hole is bonded with a second aluminum film 1113.
The specific using and implementing process is as follows: taking a brand-new unused nano enzyme chromatography reagent card box 11 (hereinafter referred to as a reagent card box 11 for short), firstly rotating a puncture sleeve 1104 on a storage bottle 1105 to ensure that a first sharp spike 1114 punctures a first aluminum film 1112, mixing a liquid A and a liquid B into a color developing solution, placing the storage bottle 1105 in a boss 1111 on the reagent card box 11, aligning an insertion plate at the bottom of the storage bottle 1105 with a gap between rib plates, and supporting the storage bottle 1105 by the rib plates and the sharp spikes 1114 on the rib plates. The reagent cartridge 11 is inserted into the loading slot 104 of the reagent cartridge transporting mechanism 10 through the insertion port of the casing, the reagent cartridge 11 is positioned and held by the catching protrusion, and the stepping belt 101 is actuated to pull the loading base 103 to move the reagent cartridge 11 along the slide bar 102 to the analysis station and stop.
Simultaneously with or before inserting the reagent cartridge 11, the evacuated blood collection tube 22 for collecting the blood sample to be tested is put into the conveying belt 522 of the blood collection tube cap-rotating code-scanning mechanism 5 from another opening on the housing, and is moved to the positioning roller 515 under the pushing of the conveying plate 507, the conveying belt 522 is stepped by a distance that the evacuated blood collection tube 22 pushes the positioning roller 515 outwards but not through the positioning roller 515, so that the mounting clip moves outwards against the spring 514, the push rod 504 and the push block 521 are pushed inwards by the action of the lever 517, so that the clamping plate 518 moves inwards, and the rubber layer 505 on the upper part of the clamping plate 518 is in contact with the side wall of the evacuated blood collection tube 22 to form a clamping which is a slight clamping with weak strength. While the rack 503 of the lower portion of the clamp plate 518 is engaged with the upper side teeth of the step gear 501. Step gear 501 is started, so that two clamping plates 518 move relatively to rub vacuum blood collection tube 22, vacuum blood collection tube 22 rotates in place, and positioning rollers 515 support the upper portion of vacuum blood collection tube 22 in a rolling manner, so that stability of vacuum blood collection tube 22 is guaranteed. The bar code on the surface is exposed in the rotating process of the vacuum blood collection tube 22, so that the bar code can be accurately scanned and read by the scanning head, and the blood sample identity information can be accurately acquired by the central control computer 9.
The lower side teeth and the one-way gear 502 are in meshed transmission when the stepping stepped gear 501 operates, the one-way bearing inside the one-way gear 502 is locked to enable the driving rod 506 connected with the rotating shaft to rotate, the driving rod 506 rotates to enable the chute 508 on the driving rod to rotate, the chute 508 rotates to enable the supporting rod 509 connected with the chute 508 through the bearing to be pulled by the chute 508 to vertically lift along the guide rod 510, the specific lifting process is that the driving rod 506 rotates to enable the supporting rod 509 to descend in the first half cycle, and the driving rod 506 rotates to enable the supporting rod 509 to ascend in the. The cutting sleeve 513 moves downwards in the process that the supporting rod 509 descends to clamp the rubber clamping ring 512 on the safety cover 33 of the vacuum blood collection tube 22, clamping of the safety cover 33 is completed, the rubber clamping ring 512 extracts the safety cover 33 from the tube body of the vacuum blood collection tube 22 in the process that the supporting rod 509 ascends again, the vacuum blood collection tube 22 is twisted by the clamping plate 518 in the lifting process, resistance received in the extracting process is smaller, removal of the safety cover 33 and bar code scanning of the vacuum blood collection tube 22 can be completed simultaneously, and the automatic and efficient vacuum blood collection tube is more automatic. After the safety cover 33 is removed and the code scanning is completed, the stepping stepped gear 501 reversely rotates, the one-way bearing freely rotates at the moment, the rotation of the one-way gear 502 does not drive the driving rod 506, the clamp plate 518 is reset, and the conveyer belt 522 again rotates step by step to convey the cover-removed code-scanned evacuated blood collection tube 22 to the front side of the sample adding mechanism 4.
In the process of adding the sample, the TIP head is clamped firstly, the TIP head in the feeding groove 609 in the TIP head dismounting mechanism 6 is clamped into the C-shaped groove 604 of the feeding rod 603 one by one under the pushing of the feeding spring 611 and the feeding plate 610, and the C-shaped groove 604 of the feeding rod 603 is opposite to the opening at the end of the feeding groove 609 in the preset initial state. The slide carriage 402 of the sample adding mechanism 4 moves to the TIPTIP head dismounting mechanism 6 under the traction of the driving belt 409, the fixed cover 406 impacts the collision switch 607, the step gear 606 is meshed with the external gear 407, the step gear 606 drives the external gear 407 to rotate, so that the rotating column rotates 180 degrees, a pipette 408 moves to the obliquely upper part of the feeding rod 603, then the telescopic driving piece 602 is started to extend the feeding rod 603 forwards, and the TIP head in the C-shaped groove 604 is opposite to the pipette 408 when the preset end point is formed. And starting the lifting driving member 601 to lift the feeding rod 603 upwards, so that the feeding rod 603 pushes and clamps the TIP head in the C-shaped groove 604 on the pipette 408, and thus, the TIP clamping of one pipette 408 is initially completed. Preferably, the C-shaped groove 604 is tapered vertically, and in the process, the baffle 605 blocks the end opening of the feeding groove 609 to prevent the TIP head in the feeding groove 609 from falling off under the pushing of the feeding plate 610. The feeding rod 603 is lowered by the lifting driving member 601, the telescopic driving member 602 retracts the feeding rod 603 to complete the reset, and the next TIP enters the C-shaped groove 604 for standby.
After the TIP head is clamped, the sliding seat 402 moves to the upper part of the vacuum blood collection tube 22 which is finished with cover taking and code scanning by the driving belt 409 again, the pipettor is lowered by starting the driving telescopic piece 405, so that the TIP head is inserted into a blood sample in the vacuum blood collection tube 22, negative pressure in the TIP head is transmitted to the TIP head by starting the piston cylinder 403 through the negative pressure tube 404 and the pipette 408, the blood sample is quantitatively extracted, and the quantification is finished by the stroke of the piston cylinder 403 and the generated negative pressure. After the blood sample is extracted, the telescopic member 405 is driven to lift the pipettor to separate from the vacuum blood collection tube 22, the pipettor after the blood sample is extracted drives the TIP head to move above the reagent cartridge 11 under the traction of the driving belt 409, the TIP head directly faces the sample groove 1102 of the reagent cartridge 11, and the piston cylinder 403 is reset again to drop the extracted blood sample into the sample groove 1102. Then moving to the end of the slide rail 401 again, triggering the collision switch 607 again, the stepping motor drives the external gear 407 again, at this time, the used TIP head rotates 180 degrees along with the pipette 408, the upper end of the TIP head slides and contacts the inner bottom wall of the spiral releasing piece 608 during the rotation, the TIP head is pushed from top to bottom by the spiral releasing piece 608 during the continuous rotation, the used TIP head is scraped off the pipette 408 by the spiral releasing piece 608, and a collecting groove is preferably arranged below to collect the used TIP head in a centralized way. In the process, another pipette 408 moves to the position obliquely above the feeding rod 603, so that the next clean TIP head can be clamped for standby.
The addition of the diluent may be performed before, after, or simultaneously with the completion of the aforementioned sample addition step. After the reagent cartridge 11 is moved to a fixed position and stopped, the end of the feeding pipe 802 of the diluent adding mechanism 8 is over against the diluent tank 1101 on the reagent cartridge 11, the stepping turning plate 803 is controlled to open a diluent bag upwards to fall out into the diluent tank 1101, then the resetting closing is carried out to avoid the redundant diluent bag from falling out, the pressure plate 804 at the lower end of the stepping turning plate 803 extrudes the diluent bag on the diluent tank 1101 downwards in the resetting process, so that the diluent bag is punctured by the puncturing rod 1106 in the diluent tank 1101 from bottom to top, and the diluent in the diluent bag flows out to enter the diluent tank 1101.
The mixing of the blood sample and the diluent is realized through the mixing mechanism 7, after the reagent card box 11 moves to the right position, the stirrer is positioned below the mixing cavity 1108 of the reagent card box 11, and the suction pipe 702 of the suction cylinder 701 of the mixing mechanism 7 is inserted into the left port of the pneumatic pipe 1107 on the left side wall of the card box body. After the sample and diluent are added, the suction driving unit 703 is activated to generate a negative pressure in the suction cylinder 701, and the negative pressure is transmitted to the mixing chamber 1108 in the cassette body through the suction tube 702, so that the mixing bag 1109 in the mixing chamber 1108 is sucked and expanded, and a negative pressure is generated inside the mixing bag 1109, thereby sucking the diluent in the diluent tank 1101 and the blood sample in the sample tank 1102 into the mixing bag 1109. And then the stirring motor 706 is started, so that the stirring disc 704 drives the magnet 705 to rotate, the magnet 705 rotates to pull the magnetic beads 1110 in the mixing bag 1109 to move, so that the diluent and the blood sample are uniformly mixed in the mixing bag 1109, the stirring motor 706 is stopped after mixing, the suction driving piece 703 is controlled to reset, so that the mixing bag 1109 is pushed and compressed by gas, and under the setting of the first one-way valve, the second one-way valve and the third one-way valve, the mixed sample in the mixing bag 1109 is injected into the fixed groove 1103, so that the test paper in the fixed groove 1103 is impregnated.
After the uniform mixing sample is injected into the fixing groove 1103, it is determined that the nanoenzyme immunochromatography is completed after a certain preset time, and the color developing solution can be loaded. The color developing liquid is loaded by the color developing liquid loading mechanism 2. Before the reagent card box 11 enters the casing, the mixing of the color developing solution is primarily completed through the operation of the storage bottle 1105 and the puncturing sleeve 1104, the loading of the color developing solution in the test analysis process is performed, the pressing rod 202 is driven to descend by controlling the action of the pressing driving member 201 of the color developing solution loading mechanism 2, the pressing head 203 on the pressing rod 202 presses the storage bottle 1105 downwards, the storage bottle 1105 is supported by the contact of the second aluminum film 1113 and the sharp pricks 1114 on the rib plates in the boss 1111 at the moment, the second aluminum film 1113 is punctured after being pressed, the storage bottle 1105 moves downwards under the guidance of the gap between the insert plate and the rib plates, the color developing solution enters the inner hole of the boss 1111 and enters the fixing grooves 1103 through the communicating cavity, and enters the fixing grooves 1103 from the two ends respectively with the. The pressing driving member 201, the lifting driving member 601, the telescopic driving member 602, the suction driving member 703 and the driving telescopic member 405 are all in a screw pair structure driven by a motor.
The sample and the color developing solution are adsorbed on the test strip in the fixed groove 1103 and develop color after a certain time of reaction, the test strip in the fixed groove 1103 is photographed by the camera 3 to obtain a pattern of the nano enzyme chromatography reaction, preferably, the camera 3 is matched with an LED lighting and single chip microcomputer, the single chip microcomputer performs noise elimination processing on the pattern to provide the influence of noise on an original signal as much as possible, the processed pattern data is transmitted to the central control computer 9, after the central control computer 9 obtains related data, the concentration of a measured substance on the nano enzyme immunochromatography test strip is obtained by utilizing built-in data characteristics for calculation, and the concentration is displayed in real time by a display.
The foregoing is merely an example of the present invention and common general knowledge in the art of designing and/or characterizing particular aspects and/or features is not described in any greater detail herein. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several variations and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (10)
1. The utility model provides a full-automatic chromatography analyzer, includes the shell, installs the display on the shell, is equipped with well control computer and camera on the base in the shell, its characterized in that: the base is also provided with a developing solution loading mechanism for triggering the uniform mixing and loading of the developing solution on the kit; the blood collection tube rotary cover code scanning mechanism is used for removing the safety cap of the vacuum blood collection tube and scanning the code of the bar code of the vacuum blood collection tube; the TIP head dismounting mechanism is used for dismounting and replacing the blood sample sucking TIP head; a sample adding mechanism for connecting the TIP head to add a blood sample into the kit; a diluent addition mechanism for adding a diluent to the kit; the blending mechanism is used for uniformly mixing the blood sample and the diluent in the kit; the kit conveying mechanism is used for conveying the kit to a corresponding position for adding blood samples, diluent and developing solution and taking pictures; the color development liquid loading mechanism, the blood collection tube rotary cover code scanning mechanism, the TIP head dismounting mechanism, the sample adding mechanism, the diluent adding mechanism, the mixing mechanism and the kit conveying mechanism are all electrically connected with a central control computer, the color development liquid loading mechanism, the camera, the blood collection tube rotary cover code scanning mechanism, the TIP head dismounting mechanism and the sample adding mechanism are all located on the right side of the kit conveying mechanism, the central control computer and the diluent adding mechanism are all located on the left side of the kit conveying mechanism, and the mixing mechanism is located on the feeding conveying front side of the kit conveying mechanism.
2. The fully automatic chromatographic analyzer according to claim 1, characterized in that: the reagent box conveying mechanism comprises a stepping belt and a sliding rod which are arranged in parallel, a loading seat is connected to the sliding rod in a sliding mode and is connected with the stepping belt through bolts, a loading groove parallel to the sliding rod is formed in the upper end of the loading seat, and an elastic clamping protrusion is arranged on the inner side wall of the loading groove.
3. The fully automatic chromatographic analyzer according to claim 2, characterized in that: the blood collection tube cap-screwing code-scanning mechanism comprises a conveying belt, clamping plates are arranged on the left side and the right side of the conveying belt, racks are arranged on the lower portions, facing the side wall of the conveying belt, of the clamping plates, stepping stepped gears are arranged between the two racks, the racks are intermittently meshed with the stepping stepped gears, vertical positioning rollers are arranged above the clamping plates, levers are connected between the positioning rollers and the clamping plates, and springs connected with a shell are arranged on one sides, away from the conveying belt, of the positioning rollers; a sweeping head is arranged on the outer side of each lever and faces to the position between the two levers.
4. The fully automatic chromatographic analyzer according to claim 3, characterized in that: step-by-step gear meshing has single gear, and single gear coaxial coupling has the actuating lever, is equipped with the chute of circumference on the actuating lever, and the conveyer belt top is equipped with the cutting ferrule, and the cutting ferrule is connected with branch, and the branch tip inserts in the chute, is equipped with bellied rubber snap ring on the inner wall of cutting ferrule lower part, and the branch cover is established on vertical guide bar, and the guide bar is connected on the shell, and the cutting ferrule top is connected with the collection hose.
5. The fully automatic chromatographic analyzer according to claim 4, characterized in that: the sample adds the mechanism and includes the slide rail, and the slide rail strides and establishes the terminal top of sweeping a yard mechanism conveyer belt at heparin tube spiral cover, and sliding connection has the slide on the slide rail, and the slide bottom mounting has the telescopic link, and the telescopic link bottom mounting has the pipettor, and the pipettor is including rotating post and fixed lid, integrated into one piece has the outer gear on the lateral wall of rotation post, and the rotation bottom of the post portion is fixed with two vertical pipettes that run through the rotation post, and two pipettes are in order to rotate the axis symmetric distribution of post, fixed lid rotates to be connected in the rotation post upper end, and the intercommunication has the negative pressure pipe on the fixed lid, and the negative pressure pipe intercommunication has a piston section.
6. The fully automatic chromatographic analyzer according to claim 5, characterized in that: TIP head dismouting mechanism includes the chute feeder, the lift driving piece, flexible driving piece, step gear and spiral break away from the piece, the chute feeder distributes with flexible driving piece horizontal perpendicular, flexible driving piece is fixed on lift driving piece top, there is the flitch with pay-off spring coupling in the chute feeder, the end fixing of flexible driving piece has the material loading pole, C type groove has been seted up on the lateral wall of material loading pole orientation chute feeder, step gear adds the external gear intermittent type meshing in the mechanism with the sample, the spiral breaks away from the piece and is located the sample and adds the terminal outside of the horizontal translation orbit of pipette in the mechanism.
7. The fully automatic chromatographic analyzer according to claim 6, characterized in that: mixing mechanism is equipped with the piston including sucking a section of thick bamboo and agitator in the suction section of thick bamboo, and the piston is connected with the suction driving piece, and a suction tube is equipped with the suction tube, and the suction tube sets up towards the removal orbit end of loading seat in the kit conveying mechanism, and the agitator includes the agitator disk, and the agitator disk upper end is inlayed and is equipped with magnet, and the agitator disk bottom is connected with agitator motor, and the agitator disk is located loading seat below.
8. The fully automatic chromatographic analyzer according to claim 7, characterized in that: the color developing liquid adding mechanism comprises a vertical pressing driving piece, a pressing rod extending to the upper side of the loading seat is fixed to the top of the pressing driving piece, and a pressing head is arranged at the end of the pressing rod.
9. The fully automatic chromatographic analyzer according to claim 8, characterized in that: the diluent adds mechanism includes the conveying pipe, and the conveying pipe is connected with the hopper, and a plurality of diluent package are adorned to the splendid attire in the hopper, and the conveying pipe end is equipped with step-by-step board that turns over, and step-by-step board bottom integrated into one piece that turns over has the clamp plate.
10. The fully automatic chromatographic analyzer according to claim 9, characterized in that: the diluent bag is a spherical plastic bag with diluent packaged inside.
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| CN202011564890.0A CN112557678B (en) | 2020-12-25 | 2020-12-25 | Full-automatic chromatographic analyzer |
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| CN202011564890.0A CN112557678B (en) | 2020-12-25 | 2020-12-25 | Full-automatic chromatographic analyzer |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114018943A (en) * | 2021-11-03 | 2022-02-08 | 美东汇成生命科技(昆山)有限公司 | Detection device for liquid transfer suction head |
| CN114397168A (en) * | 2022-03-28 | 2022-04-26 | 深圳市开颜医疗器械有限公司 | Internet-based body fluid balance intelligent health detection equipment and detection method |
| CN115684140A (en) * | 2023-01-05 | 2023-02-03 | 江苏协鲲生物技术有限责任公司 | Reagent card, homogeneous phase chemiluminescence detection system and homogeneous phase chemiluminescence detection method |
| CN116754758A (en) * | 2023-08-24 | 2023-09-15 | 遂宁市中心医院 | Sepsis immune function monitoring facilities |
| CN116859070A (en) * | 2023-09-01 | 2023-10-10 | 广东南国药业有限公司 | Sampling detection device and detection method for medicine production |
| CN117871853A (en) * | 2024-03-13 | 2024-04-12 | 南通戴尔诺斯生物科技有限公司 | Colloidal gold immunochromatography equipment for detecting biotoxin and application method thereof |
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| CN114018943A (en) * | 2021-11-03 | 2022-02-08 | 美东汇成生命科技(昆山)有限公司 | Detection device for liquid transfer suction head |
| CN114397168A (en) * | 2022-03-28 | 2022-04-26 | 深圳市开颜医疗器械有限公司 | Internet-based body fluid balance intelligent health detection equipment and detection method |
| CN115684140A (en) * | 2023-01-05 | 2023-02-03 | 江苏协鲲生物技术有限责任公司 | Reagent card, homogeneous phase chemiluminescence detection system and homogeneous phase chemiluminescence detection method |
| CN115684140B (en) * | 2023-01-05 | 2023-08-15 | 江苏协鲲生物技术有限责任公司 | Reagent card, homogeneous chemiluminescence detection system and homogeneous chemiluminescence detection method |
| CN116754758A (en) * | 2023-08-24 | 2023-09-15 | 遂宁市中心医院 | Sepsis immune function monitoring facilities |
| CN116754758B (en) * | 2023-08-24 | 2023-10-20 | 遂宁市中心医院 | Sepsis immune function monitoring facilities |
| CN116859070A (en) * | 2023-09-01 | 2023-10-10 | 广东南国药业有限公司 | Sampling detection device and detection method for medicine production |
| CN116859070B (en) * | 2023-09-01 | 2023-11-07 | 广东南国药业有限公司 | Sampling detection device and detection method for medicine production |
| CN117871853A (en) * | 2024-03-13 | 2024-04-12 | 南通戴尔诺斯生物科技有限公司 | Colloidal gold immunochromatography equipment for detecting biotoxin and application method thereof |
| CN117871853B (en) * | 2024-03-13 | 2024-05-24 | 南通戴尔诺斯生物科技有限公司 | Colloidal gold immunochromatography equipment for detecting biotoxin and application method thereof |
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