CN116859070B - Sampling detection device and detection method for medicine production - Google Patents
Sampling detection device and detection method for medicine production Download PDFInfo
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- CN116859070B CN116859070B CN202311122513.5A CN202311122513A CN116859070B CN 116859070 B CN116859070 B CN 116859070B CN 202311122513 A CN202311122513 A CN 202311122513A CN 116859070 B CN116859070 B CN 116859070B
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000005070 sampling Methods 0.000 title claims abstract description 36
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 17
- 238000001514 detection method Methods 0.000 title abstract description 26
- 238000012360 testing method Methods 0.000 claims abstract description 173
- 239000002184 metal Substances 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 15
- 238000001125 extrusion Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 238000004891 communication Methods 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 4
- 238000010998 test method Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229940127557 pharmaceutical product Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 description 18
- 238000001179 sorption measurement Methods 0.000 description 10
- 238000007664 blowing Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000009778 extrusion testing Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0491—Position sensing, encoding; closed-loop control
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- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Hydrology & Water Resources (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention relates to the technical field of sample detection, in particular to a sampling detection device for medicine production and a detection method thereof, comprising a base, a conveying frame body arranged on one side of the base, a fixing frame, a rotating piece, a fixing frame, a sliding groove, a cylinder piece, a positioning groove, a sliding groove and a locking groove, wherein the test tube to be sampled is placed on one side of the conveying frame body; and the moving part is movably connected to the sliding groove, and one side of the moving part is fixedly connected with the lap joint part through the connecting frame. Through the rotation piece that sets up to place the test paper and realize solitary sampling at rotation piece downside, the medicine of every turn sampling can correspond different test papers, effectually avoided the confusion between the medicine sample between the different test tubes, guaranteed the accuracy of sampling.
Description
Technical Field
The invention relates to the technical field of sample detection, in particular to a sampling detection device and a detection method for medicine production.
Background
Drug testing is an important process in drug research and manufacturing, and is directly related to the quality of drugs and the safety of users. The quality detection of medicines is enhanced in the country, so that the medicines are required to be detected by using the medicine detection device in the aspects of scientific research, development and production of the medicines so as to ensure the quality qualification of the medicines.
The existing sampling detection device samples medicines by adopting the acquisition end, but detects different medicines for multiple times by adopting the same acquisition end, and samples in different test tubes are easy to be confused, so that the sampling detection result is inaccurate.
Disclosure of Invention
The invention provides a sampling detection device and a detection method thereof for medicine production, which can effectively solve the problems that the sampling detection device adopts a collection end to sample medicines, but adopts the same collection end to detect different medicines for a plurality of times, so that samples in different test tubes are easy to be confused, and the sampling detection result is inaccurate.
In order to achieve the above purpose, the invention is realized by the following technical scheme:
the invention provides a sampling detection device for medicine production, which comprises a base, a conveying frame body arranged on one side of the base, a fixing frame, a barrel part, a rotating part, a first piston rod, a driven tooth, a lap joint ring, a through groove, a connecting pipe and an air pump, wherein the test tube to be sampled is arranged on one side of the conveying frame body; and the moving part is movably connected to the sliding groove, and one side of the moving part is fixedly connected with the lap joint part through the connecting frame.
Further, the size of the lap ring is the same as that of the test paper; when the outside air pump is inhaled through the connecting pipe, the test paper can be stabilized and adsorbed in the downside position of lap joint ring, and when the outside air pump is blown through the connecting pipe, the test paper no longer is adsorbed to when the motor rotates, the test paper can correspond with the test tube position on the carriage body.
Further, the device also comprises a second piston tube fixedly arranged on the fixed frame, a cavity is formed in one side of the second piston tube, a hose is further communicated with one side of the cavity, a second piston rod is movably connected to the cavity, and the second piston rod is fixedly connected with the outer wall of the moving part; the second piston rod is fixedly connected with the outer wall of the moving part through a spring.
Further, the device also comprises a first piston tube fixedly arranged on the base; the first piston tube is communicated with the second piston tube; when the rotating piece moves downwards, the first piston rod slides in the first piston tube, and gas in the first piston tube is pressed into the second piston tube to drive the second piston rod and the moving piece fixedly connected with the second piston rod to slide in the sliding groove.
Further, the device also comprises a scraping plate fixedly arranged at one side of the upper end of the moving piece, and the outer wall of the upper end of the scraping plate is in friction contact with the outer wall of the test paper adsorbed at the lower side of the lap joint ring; the roller is fixedly arranged on the other side of the upper end of the moving piece, and the outer wall of the roller is contacted with the outer wall of the test paper on the lower side of the lap joint ring; when the moving piece moves reciprocally, the scraper can flatten the liquid medicine adhered to the test paper, and the roller can squeeze the test paper to enable the test paper to be adhered to the outer wall of the lower side of the lap joint ring better; a cavity is formed in the roller and is communicated with a cavity formed in the second piston tube.
Further, still include the extrusion piece, set up on the carriage body, when the lap joint ring moves down to the downside position, the test paper of being adsorbed at the lap joint ring downside seals the test tube, extrusion piece extrusion test tube makes fine submergence of liquid medicine on the test paper.
Further, the device also comprises a triggering unit for controlling the magnetic adsorption relation between the magnetic adsorption layer arranged on the inner wall of the upper end of the barrel and the magnetic adsorption ring movably connected to the middle part of the barrel; the sliding chute comprises a first metal piece fixedly arranged on the outer wall of the lower end of the moving piece and a second metal piece arranged on the sliding chute; when the first metal piece is in contact with the second metal piece, the magnetic attraction layer and the magnetic attraction ring repel each other, the magnetic attraction ring moves downwards along the placing groove, and when the first metal piece is not in contact with the second metal piece, the magnetic attraction layer and the magnetic attraction ring attract each other, and the magnetic attraction ring resets to keep the contact relation with the magnetic attraction layer.
Further, the caliber of the magnetic attraction ring is matched with the size of the test paper; the inner wall of the magnetic attraction ring is provided with a friction layer.
Further, the device also comprises a bag fixedly arranged on the outer wall of the barrel; when the moving piece moves reciprocally in the chute, the outer wall of the lap joint piece is contacted with the outer wall of the bag body and extrudes the bag body; the inner wall of the placing groove is also provided with an inclined groove which is communicated with the inner wall of the bag body.
A sampling detection method for medicines is applied to a sampling detection device for medicine production, and comprises the following steps:
s1: arranging test tubes on a conveying frame body, and adsorbing the test tubes on the lower side of a lap joint ring by combining an external air pump;
s2: the height of the rotating piece in the vertical direction is adjusted through an external air cylinder, and the rotating piece is driven to rotate through a motor in the process, so that a lap joint ring on the rotating piece is aligned with a test tube to be sampled;
s3: the extrusion part extrudes the test tube, so that the liquid medicine is immersed on the test paper, and the extrusion part is reset;
s4: then, an external motor is utilized to drive the arranged rotating piece to rotate ninety degrees, so that the lap joint ring is adjusted in position, the other lap joint ring is positioned at the upper side of the test tube, in the process, the moving piece slides in the chute, the scraper can flatten the test paper, the liquid medicine can be fully coated with the test paper, and meanwhile, the roller can squeeze the test paper to enable the test paper to be adhered to the outer wall of the lower side of the lap joint ring;
s5: when the rotating piece rotates ninety degrees again, the test paper can be positioned on the upper side of the barrel, at the moment, the external air pump does not adsorb the test paper any more, and blows air to enable the test paper to fall into the barrel, and blows out from the inclined groove to enable the test paper to stably fall into the lower side of the barrel, and drives the test paper to fall into the lower side of the barrel through the magnetic attraction belt.
Advantageous effects
Compared with the known public technology, the technical scheme provided by the invention has the following beneficial effects:
according to the invention, through the arranged rotating piece, and the test paper is placed on the lower side of the rotating piece to realize independent sampling, medicines sampled each time can correspond to different test papers, thereby effectively avoiding confusion among medicine samples among different test tubes and ensuring the sampling accuracy.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It is evident that the drawings in the following description are only some embodiments of the present invention and that other drawings may be obtained from these drawings without inventive effort for a person of ordinary skill in the art.
FIG. 1 is a schematic diagram of the overall structure of a sampling detection apparatus according to the present invention;
FIG. 2 is a schematic diagram of the overall explosive structure of the sampling detection device of the present invention;
FIG. 3 is a schematic view of the structure of the rotary member of the present invention;
FIG. 4 is a schematic view of an exploded view of a moving part according to the present invention;
FIG. 5 is a schematic diagram of an exploded construction of a second piston tube according to the present invention;
FIG. 6 is a schematic cross-sectional view of a cartridge of the present invention;
fig. 7 is a flow chart of a sample detection method according to the present invention.
Reference numerals
100. A base; 110. a conveying frame body; 120. a fixing frame; 121. a chute; 122. a second metal piece; 130. a first piston tube;
200. a rotating member; 210. a first piston rod; 220. a lap ring; 221. a through groove; 230. a connecting pipe;
300. a second piston tube; 301. a cavity; 310. a hose; 320. a second piston rod; 330. a spring;
400. a moving member; 410. a scraper; 420. a roller; 430. a connecting frame; 431. a bridge;
500. a barrel; 501. a placement groove; 502. a magnetic attraction layer; 503. an inclined groove; 510. a bladder; 520. a magnetic ring;
600. an extrusion.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. It will be apparent that the described embodiments are some, but not all, embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention is further described below with reference to examples.
Embodiment one:
referring to fig. 1-6, a sampling detection device for pharmaceutical production, including a base 100, a fixing frame 120 is further installed on the base 100, a chute 121 is formed on the fixing frame 120, and a conveying frame 110 is disposed on one side of the base 100, the conveying frame 110 can realize intermittent conveying of test tubes, specifically, a conveying belt can be disposed on the bottom surface of the conveying frame 110, and an external servo motor is used to control a rotating motor, so that intermittent conveying of the conveying belt is realized, each time of stopping conveying, test tubes on the conveying frame 110 are all located at a sampling station, so that subsequent better sampling can be performed, and test tubes to be sampled are placed on one side of the conveying frame 110;
the rotating member 200 is fixedly connected with the output end of the air cylinder and drives the rotating member 200 to reciprocate in the vertical direction, under the action of the external air cylinder, the rotating member 200 can be driven to reciprocate in the vertical direction, when the air cylinder drives the rotating member 200 to move to the lowest side position, one of the plurality of lap rings 220 arranged on the circumferential outer wall of the rotating member 200 can be aligned with a test tube, the lower side of the lap ring 220 in the state is adsorbed with test paper, the test paper can be well contacted with the end part of the test tube and effectively sealed, driven teeth are fixedly arranged at the upper end of the rotating member 200 and are meshed with active teeth arranged on a motor, when the rotating member 200 is at the uppermost position, the plurality of lap rings 220 arranged on the circumferential outer wall of the rotating member 200 need to be adjusted in position, so that the test paper adsorbed at the lower side position of the lap ring 220 can be rotated to a sampling station from other positions, the test paper can be sampled, then the lower side of the lap ring 220 is driven by the air cylinder to move down to carry out test paper, the test paper can be well contacted with the end part of the test tube, the test paper can be effectively sealed with the end part of the test tube, the test paper can be meshed with the active teeth, the active teeth are meshed with the active teeth of the test tube, the active teeth of the test tube are not arranged in the rotating member 200, and the active teeth are meshed with the active teeth, and the active teeth are not meshed with the active teeth, and the active teeth are meshed with the active teeth of the active teeth 200, and the active teeth are arranged on the active teeth, and the active teeth are meshed with the active teeth 200.
In this case, regarding how to keep stable adsorption between the test paper and the lap ring 220, adsorption and separation between the test paper and the lap ring 220 are achieved by controlling suction or blowing of an external air pump, specifically, a through groove 221 is formed in the middle of the lap ring 220, the through groove 221 is kept in communication with a connecting pipe 230 fixedly installed on the lap ring 220, the connecting pipe 230 is kept in communication with an output end of the external air pump, when suction is performed by the external air pump, the air is sucked from the lower side of the through groove 221 by combining the communication relationship between the connecting pipe 230 and the through groove 221, and at this time, by placing the test paper on the lower side of the lap ring 220, effective adsorption of the test paper can be achieved by the relationship of positive and negative pressure, and the adsorption relationship is kept until sampling is completed, and when required, the external air pump is changed from suction to blowing, thereby achieving separation between the lap ring 220 and the test paper. The size of the landing ring 220 is the same as the test strip size, so that it can be ensured that the test strip can be stably adsorbed at the lower side of the landing ring 220.
In order to better understand the scheme, the test paper is first installed in a test paper installation link, which is the test paper installation station along the direction opposite to the rotation direction of the rotation piece 200 and ninety degrees along the rotation direction, firstly, the test paper is placed under the lap joint ring 220, and the test paper is effectively adsorbed by using an external air pump, so that the test paper is completely installed;
then, the lapping ring 220 adsorbed with the test paper is rotated by ninety degrees by utilizing an external motor, so that the test paper can be aligned with the test paper on the conveying frame body 110, and the diameter of the test paper in the case is larger than the caliber of the test paper, after the test paper is aligned with the test paper, the rotating piece 200 is driven by an external cylinder to adjust the position from top to bottom, at the moment, the test paper positioned at the lower side of the lapping ring 220 can seal the upper end opening of the test paper, and the test paper is worth noting that the test paper is made of plastic material and used for loading liquid medicine, and the test paper also comprises an extrusion piece 600 which is arranged on the conveying frame body 110, when the lapping ring 220 moves to the lowest side, the test paper adsorbed at the lower side of the lapping ring 220 seals the test paper, the extrusion piece 600 extrudes the test paper so that the liquid medicine is well immersed on the test paper, and the test paper is extruded by the extrusion piece 600 so that the test paper positioned in the test paper can be well immersed on the lower side of the lapping ring 220, and sampling is completed in the way;
when the sampling is completed, the external cylinder is used for driving the rotating member 200 to move to the uppermost position again, then the motor is used for driving the rotating member 200 to rotate ninety degrees, and the conveying frame 110 can also adjust the position of the test tube positioned on the rotating member 200 at the moment, the sampled test tube is conveyed continuously, a new test tube is positioned at the sampling station again, after the position adjustment of the rotating member 200 is completed, the cylinder is used for driving the rotating member 200 to move downwards to the lowermost position again, and it is worth to say that the middle part of the bottom surface of the rotating member 200 is fixedly provided with a first piston rod 210, and the novel test tube conveying frame also comprises a first piston tube 130 fixedly arranged on the base 100; the first piston tube 130 is in communication with the second piston tube 300; when the rotary member 200 moves downward, the first piston rod 210 slides in the first piston tube 130, and presses the gas in the first piston tube 130 into the second piston tube 300, so as to drive the second piston rod 320 and the moving member 400 fixedly connected with the second piston rod to slide in the sliding groove 121; the device further comprises a second piston tube 300 fixedly arranged on the fixed frame 120, a cavity 301 is formed in one side of the second piston tube 300, a hose 310 is further communicated with one side of the cavity 301, a second piston rod 320 is movably connected to the cavity 301, and the second piston rod 320 is fixedly connected with the outer wall of the moving piece 400; the movable member 400 is movably connected to the sliding chute 121, one side of the movable member 400 is fixedly connected to the lap joint 431 through the connecting frame 430, the second piston rod 320 is fixedly connected to the outer wall of the movable member 400 through the spring 330, when the set rotatable member 200 moves downwards, the first piston rod 210 fixedly installed at the lower end of the rotatable member 200 slides in the first piston tube 130, when the rotatable member 200 moves to the lowest position, the gas originally in the first piston tube 130 enters the second piston tube 300 in combination with the communication relation between the set first piston tube 130 and the second piston tube 300, and then the second piston rod 320 movably connected in the second piston tube 300 performs position adjustment, and when the rotatable member 200 moves to the lowest position, the gas enters the second piston tube 300 from the first piston tube 130 in combination with the fixed connection relation between the second piston rod 320 and the movable member 400, so that the movable member 400 can slide in position on the sliding chute 121, and it is worth to say that a control valve is arranged on the communication pipe fitting between the first piston tube 130 and the second piston tube 300;
when gas enters the second piston tube 300, a second piston rod 320 movably connected in the second piston tube 300 can adjust the position, so as to drive the moving member 400 to slide in the sliding groove 121, and the device further comprises a scraper 410 fixedly arranged on one side of the upper end of the moving member 400, wherein the outer wall of the upper end of the scraper 410 is in friction contact with the outer wall of test paper adsorbed on the lower side of the lap joint ring 220; and a drum 420 fixedly installed at the other side of the upper end of the moving member 400, the outer wall of the drum 420 being in contact with the outer wall of the test paper at the lower side of the landing ring 220; when the moving member 400 reciprocates, the scraper 410 will flatten the liquid medicine adhered to the test paper, and the roller 420 will squeeze the test paper to make it adhere better to the lower outer wall of the lap ring 220; the cylinder 420 has a cavity formed therein which is in communication with the cavity 301 formed in the second piston tube 300. When the moving member 400 is moved in the chute 121, the scraper 410 is first disposed to smear the outer wall of the lower side of the test paper immersed with the medicine, and some liquid medicines may be sticky due to different characteristics of the medicines and accumulate on the lower side of the test paper to prevent subsequent content detection, so that the medicine on the test paper can be flattened by the disposed scraper 410, and the other side of the moving member 400 is further rotatably connected with the roller 420, and as the moving member 400 moves, the roller 420 rotatably connected to the moving member 400 rolls on the lower side of the lap ring 220 mounted with the test paper to flatten the test paper adsorbed on the lower side of the lap ring 220, thereby ensuring that the test paper cannot be wrinkled due to adsorption.
It should be noted that, one side of the second piston tube 300 is also communicated with the cavity formed in the roller 420 through the hose 310, when the gas enters the second piston tube 300, the gas drives the second piston rod 320 to adjust the position, and in the adjusting process, when the second piston rod 320 moves to one side of the hose 310, the gas enters the cavity through the hose 310, so that the roller 420 expands, the elastic contact relation with the test paper is increased, the effect of processing the test paper is improved, and it should be noted that, in the process, the position of the second piston rod 320 is kept fixed, and at the moment, the position of the moving member 400 also keeps the fixed gas continuously entering the cavity from the hose 310.
The above-mentioned medicines are pretreated by the scraper 410, so that the medicines can be stably immersed in the test paper, then the test paper needs to be unloaded, at this time, the rotating member 200 is driven to move to the uppermost position by using the external air cylinder, then the rotating member 200 is driven to rotate ninety degrees by using the external motor, then the rotating member 200 is driven to move downwards by using the air cylinder, at this time, the test paper immersed with the liquid medicines can be subjected to position adjustment again, specifically, the base 100 is fixedly provided with the barrel 500, the middle part of the barrel 500 is provided with the placing groove 501, and the test paper comprises a triggering unit for controlling the magnetic adsorption relation between the magnetic attraction layer 502 arranged on the inner wall of the upper end of the barrel 500 and the magnetic attraction ring 520 movably connected to the middle part of the barrel 500; comprises a first metal piece fixedly arranged on the outer wall of the lower end of the moving piece 400 and a second metal piece 122 arranged on the chute 121; when the first metal piece is in contact with the second metal piece 122, the magnetic attraction layer 502 and the magnetic attraction ring 520 repel each other, the magnetic attraction ring 520 moves downwards along the placing groove 501, and when the first metal piece is not in contact with the second metal piece 122, the magnetic attraction layer 502 and the magnetic attraction ring 520 attract each other, and the magnetic attraction ring 520 is reset to maintain the contact relation with the magnetic attraction layer 502. Specifically, after the set rotating member 200 moves down, the test paper immersed with the medicine will be in a position corresponding to the barrel 500, it should be noted that, when the set moving member 400 slides in the chute 121, the first metal member fixedly installed on the lower side of the moving member 400 contacts with the second metal member 122 disposed on the chute 121, the magnetic attraction ring 520 slidingly connected to the inner side of the upper end of the placement groove 501 will be in a repulsive state with the magnetic attraction layer 502 from an adsorption relationship, and at this time, the magnetic attraction ring 520 will move from top to bottom, and the caliber of the magnetic attraction ring 520 is adapted to the size of the test paper; the friction layer is arranged on the inner wall of the magnetic attraction ring 520, the arranged friction layer can be contacted with the circumferential outer wall of the test paper, and the arranged test paper is driven to fall to the bottom of the barrel 500; and when the first metal part is not contacted with the second metal part 122, the magnetic attraction ring 520 is attracted again to the magnetic attraction layer 502, so that the magnetic attraction ring 520 is reset.
Also included is a bladder 510 fixedly mounted on the outer wall of the cartridge 500; when the moving member 400 reciprocates in the sliding groove 121, the outer wall of the lap member 431 contacts with the outer wall of the capsule 510 and presses the capsule 510; the inclined groove 503 is further formed in the inner wall of the placing groove 501, the inclined groove 503 is communicated with the inner wall of the bag body 510, when the arranged moving part 400 moves in the chute 121, the lap 431 fixedly installed on the moving part 400 can squeeze the arranged bag body 510, gas in the bag body 510 can be discharged through the arranged inclined groove 503 and blown to the test paper falling into the placing groove 501, the test paper can also fall to the bottom of the placing groove 501 and is stably arranged, the bag body 510 is extruded firstly, the gas can be blown to the test paper firstly, the test paper is worth to be interpreted, a certain weight is achieved after the test paper is immersed in the test paper, when an external air pump is changed into blowing from sucking, the blown gas can drive the arranged test paper to fall into the placing groove 501 and is located at the lower side of the inclined groove 503, then when the moving part 400 moves to the tail end of a stroke, the first metal piece can be contacted with the second metal piece 122, the magnetic suction ring 520 can move downwards in the placing groove 501, the test paper can be adjusted again by the magnetic suction ring 520, the test paper is conveniently arranged in the placing groove 501.
Embodiment two:
referring to fig. 7, a sampling test method for medicine, to which a sampling test device for medicine production is applied, comprises the steps of:
s1: arranging test tubes on the conveying frame body 110, and adsorbing the test tubes on the lower side of the lap joint ring 220 by combining an external air pump;
s2: the height of the rotating member 200 in the vertical direction is adjusted by an external cylinder, and the rotating member 200 is driven to rotate by a motor in the process, so that the lap ring 220 on the rotating member 200 is aligned with the test tube to be sampled;
s3: the squeeze 600 squeezes the test tube such that the liquid drug is immersed on the test paper and such that the squeeze 600 resets;
s4: then, the rotating member 200 is driven by an external motor to rotate ninety degrees, so that the lap ring 220 is adjusted in position, the other lap ring 220 is positioned at the upper side of the test tube, in the process, the moving member 400 slides in the sliding groove 121, the scraper 410 can flatten the test paper, the liquid medicine can be fully coated with the test paper, and meanwhile, the roller 420 can squeeze the test paper to be adhered to the outer wall of the lower side of the lap ring 220;
s5: when the rotating member 200 rotates ninety degrees again, the test paper is positioned on the upper side of the barrel 500, at this time, the external air pump does not adsorb the test paper any more, and blows air to make the test paper drop into the barrel 500, and blows out from the inclined groove 503 to make the test paper drop on the lower side of the barrel 500 stably, and drives the test paper to drop on the lower side of the barrel 500 through the magnetic attraction ring 520.
The above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; these modifications or substitutions do not depart from the essence of the corresponding technical solutions from the protection scope of the technical solutions of the embodiments of the present invention.
Claims (6)
1. A sampling test device for pharmaceutical production comprising:
the test tube sampling device comprises a base (100) and a conveying frame body (110) arranged on one side of the base (100), wherein a test tube to be sampled is placed on one side of the conveying frame body (110), a fixing frame (120) is further installed on the base (100), a sliding groove (121) is formed in the fixing frame (120), a barrel (500) is fixedly installed on the base (100), and a placing groove (501) is formed in the middle of the barrel (500);
the rotary part (200) is fixedly connected with the output end of the air cylinder and drives the rotary part (200) to reciprocate in the vertical direction, a first piston rod (210) is fixedly arranged in the middle of the bottom surface of the rotary part (200), driven teeth are fixedly arranged at the upper end of the rotary part (200) and are in meshed connection with driving teeth arranged on a motor, a lap joint ring (220) is arranged on the circumferential outer wall of the rotary part (200), a through groove (221) is formed in the middle of the lap joint ring (220), the through groove (221) is communicated with a connecting pipe (230) fixedly arranged on the lap joint ring (220), and the connecting pipe (230) is communicated with the output end of an external air pump;
the movable piece (400) is movably connected to the chute (121), and one side of the movable piece (400) is fixedly connected with the lap joint piece (431) through the connecting frame (430);
the first piston tube (130) is fixedly arranged on the base (100); the first piston tube (130) is in communication with the second piston tube (300); when the rotating piece (200) moves downwards, the first piston rod (210) slides in the first piston tube (130), and gas in the first piston tube (130) is pressed into the second piston tube (300) to drive the second piston rod (320) and the moving piece (400) fixedly connected with the second piston rod to slide in the sliding groove (121);
the device also comprises a scraper (410) fixedly arranged at one side of the upper end of the moving piece (400), wherein the outer wall of the upper end of the scraper (410) is in friction contact with the outer wall of the test paper adsorbed at the lower side of the lap joint ring (220); the roller (420) is fixedly arranged on the other side of the upper end of the moving piece (400), and the outer wall of the roller (420) is contacted with the outer wall of the test paper on the lower side of the lap joint ring (220); when the moving member (400) moves reciprocally, the scraper (410) will flatten the liquid medicine adhered to the test paper, and the roller (420) will squeeze the test paper to make it adhere better to the lower outer wall of the lap ring (220); a cavity is formed in the roller (420), and the cavity is communicated with a cavity (301) formed in the second piston tube (300);
the test tube is sealed by test paper adsorbed on the lower side of the lap ring (220) when the lap ring (220) moves downwards to the lowest side position, and the test tube is extruded by the extrusion piece (600) so that the liquid medicine is well immersed on the test paper;
the device also comprises a triggering unit, a magnetic absorption unit and a control unit, wherein the triggering unit is used for controlling the magnetic absorption relationship between a magnetic absorption layer (502) arranged on the inner wall of the upper end of the barrel (500) and a magnetic absorption ring (520) movably connected to the middle part of the barrel (500); comprises a first metal piece fixedly arranged on the outer wall of the lower end of a moving piece (400) and a second metal piece (122) arranged on a chute (121); when the first metal piece is contacted with the second metal piece (122), the magnetic attraction layer (502) and the magnetic attraction ring (520) repel each other, the magnetic attraction ring (520) moves downwards along the placing groove (501), and when the first metal piece is not contacted with the second metal piece (122), the magnetic attraction layer (502) and the magnetic attraction ring (520) attract each other, and the magnetic attraction ring (520) is reset to keep the contact relation with the magnetic attraction layer (502).
2. A sampling test device for pharmaceutical production according to claim 1, wherein,
the size of the lap ring (220) is the same as the test paper size;
when the external air pump inhales through the connecting pipe (230), the test paper can be stably adsorbed at the lower side position of the lap joint ring (220), when the external air pump blows through the connecting pipe (230), the test paper is not adsorbed any more, and when the motor rotates, the test paper can correspond to the test tube position on the conveying frame body (110).
3. A sampling test device for pharmaceutical production according to claim 2, further comprising:
the second piston tube (300) is fixedly arranged on the fixing frame (120), a cavity (301) is formed in one side of the second piston tube (300), a hose (310) is further communicated with one side of the cavity (301), a second piston rod (320) is movably connected to the cavity (301), and the second piston rod (320) is fixedly connected with the outer wall of the moving part (400);
the second piston rod (320) is fixedly connected with the outer wall of the moving part (400) through a spring (330).
4. A sampling test device for pharmaceutical production according to claim 3, wherein,
the caliber of the magnetic ring (520) is matched with the size of the test paper;
the inner wall of the magnetic attraction ring (520) is provided with a friction layer.
5. The sample testing device for pharmaceutical production of claim 4, further comprising:
a capsule (510) fixedly mounted on the outer wall of the cartridge (500);
when the moving piece (400) moves reciprocally in the sliding groove (121), the outer wall of the lap piece (431) is contacted with the outer wall of the bag body (510) and extrudes the bag body (510);
the inner wall of the placing groove (501) is also provided with an inclined groove (503), and the inclined groove (503) is communicated with the inner wall of the capsule body (510).
6. A sampling test method for a pharmaceutical product, applied to a sampling test device for pharmaceutical product production as claimed in claim 5, comprising the steps of:
s1: arranging test tubes on a conveying frame body (110), and combining an external air pump to adsorb the test tubes on the lower side of a lap joint ring (220);
s2: the height of the rotating piece (200) in the vertical direction is adjusted through an external air cylinder, and the rotating piece (200) is driven to rotate through a motor in the process, so that a lap joint ring (220) on the rotating piece (200) is aligned with a test tube to be sampled;
s3: the extrusion (600) extrudes the test tube so that the liquid medicine is immersed on the test paper and the extrusion (600) is reset;
s4: then, an external motor is utilized to drive the arranged rotating piece (200) to rotate ninety degrees, so that the lap joint ring (220) is adjusted in position, the other lap joint ring (220) is positioned at the upper side of the test tube, in the process, the moving piece (400) slides in the chute (121), the scraper (410) can flatten the test paper, the test paper can be fully coated with the liquid medicine, and meanwhile, the roller (420) can squeeze the test paper to enable the test paper to be adhered to the outer wall of the lower side of the lap joint ring (220);
s5: when the rotating part (200) rotates ninety degrees again, the test paper can be positioned on the upper side of the barrel part (500), at the moment, the external air pump does not adsorb the test paper any more, and blows air to enable the test paper to fall into the barrel part (500), and blows out from the inclined groove (503) to enable the test paper to stably fall into the lower side of the barrel part (500), and drives the test paper to fall into the lower side of the barrel part (500) through the magnetic attraction ring (520).
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| KR20050030828A (en) * | 2003-09-26 | 2005-03-31 | 주식회사 포스코 | Device for loading test piece |
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