CN114675045A - Food safety detection analytical equipment - Google Patents
Food safety detection analytical equipment Download PDFInfo
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- CN114675045A CN114675045A CN202210316965.6A CN202210316965A CN114675045A CN 114675045 A CN114675045 A CN 114675045A CN 202210316965 A CN202210316965 A CN 202210316965A CN 114675045 A CN114675045 A CN 114675045A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4022—Concentrating samples by thermal techniques; Phase changes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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Abstract
The invention discloses a food safety detection and analysis device, which comprises: the loading module comprises a gun head box, a magnetic bead extraction box and a detection test tube; the liquid transfer module comprises a first support, a first driving device, a first mounting frame, a second driving device, a first transverse plate and a liquid transfer device; the magnetic rod module comprises a second bracket, a third driving device, a second mounting block, a fifth driving device, a second mounting frame, a fourth driving device, a second transverse plate, a magnetic rod sleeve and a magnetic rod; the nitrogen blow molding block comprises a third bracket, a sixth driving device, a third mounting frame and a nitrogen blow pipe; control module blows the module, feeds the module electricity with liquid-transfering module, bar magnet module, nitrogen and is connected for the control pipettor is arranged in rifle head box, magnetic bead and draws box, detection test tube optional position, makes the pipettor reciprocate, and the control bar magnet cover is arranged in the magnetic bead and draws box position, makes bar magnet cover up-and-down reciprocating motion, makes the bar magnet stretch out and draw in the bar magnet cover from top to bottom or outside, and the control nitrogen blowpipe is arranged in the magnetic bead and draws box position, makes the nitrogen blowpipe reciprocate.
Description
Technical Field
The invention relates to the technical field of biological detection, in particular to food safety detection and analysis equipment.
Background
Pesticide, veterinary drug and biotoxin residue in food seriously threaten the health of consumers, and in recent years, public attention is paid to the problems. The colloidal gold immunochromatography is widely applied due to the advantages of simplicity, convenience, rapidness, no need of large-scale instruments and equipment and the like. The sample pretreatment is a key operation step for detecting pesticide, veterinary drug and biotoxin residues in food, and the pretreatment key link is directly related to the accuracy of the detection of the drug residues. Through sample pretreatment, the accuracy of detection of pesticide residues in food is ensured, detection technicians need to pay attention to food sample pretreatment procedures, and when various samples are pretreated, the samples are continuously sampled and lofted, so that the samples can be subjected to multi-sample detection, detection errors need to be avoided, and the food detection samples are processed in a correct mode. The immunomagnetic beads are nanoscale magnetic microspheres with chemical functional groups such as amino, carboxyl, hydroxyl or sulfydryl on the surfaces, and the functional groups can be combined with different immune ligands such as active protein, antibodies, antigens, biotin and the like to form the immunomagnetic beads. Immunomagnetic beads have been widely used for extraction and processing of biological samples, such as extraction of nucleic acids and proteins. In food analysis, the acting force of the immunomagnetic bead purification system is an external magnetic field, and magnetic field nanoparticles can move directionally in the magnetic field, so that the rapid separation of a reaction system and an unreacted system can be realized by using a magnet after the reaction is finished, and the pretreatment time can be greatly shortened.
However, the above structure has disadvantages that the sample detection result is easily affected by conditions such as omission, wrong addition and excessive addition due to large number of samples and complicated processing steps in the pretreatment process of the samples, and the detection and analysis work of the experimental result cannot be automatically performed after the experiment is completed.
Therefore, in order to solve the above problems, it is necessary to provide a new food safety detection and analysis device.
Disclosure of Invention
The purpose of the invention is as follows: the utility model provides a food safety inspection analytical equipment for solve current food safety inspection analytical equipment and carry out the influence to sample testing result because of factors such as sample quantity is big, the processing step is loaded down with trivial details in the sample pretreatment process, can't satisfy the problem of carrying out the testing analysis demand to the experimental result automatically.
The technical scheme is as follows: the invention provides a food safety detection and analysis device, which is provided with a working bottom plate and comprises: the loading module comprises a gun head box, a magnetic bead extraction box and a detection test tube which are arranged on a working bottom plate; the liquid transfer module comprises a first support extending upwards from the working bottom plate, a first mounting frame connected with the upper end of the first support through a first driving device, a first transverse plate connected with the first mounting frame through a second driving device, and a plurality of vertical pipettors arranged at the bottom of the first mounting frame; the magnetic rod module comprises a second support extending upwards from the working bottom plate, a second mounting block connected with the upper end of the second support through a third driving device, a second mounting frame connected with the second mounting block through a fifth driving device, a second transverse plate connected with the second mounting block through a fourth driving device and positioned above the second mounting frame, a plurality of vertical magnetic rod sleeves arranged at the bottom of the second mounting frame, and a plurality of vertical magnetic rods arranged at the bottom of the second transverse plate; the nitrogen blowing module comprises a third support extending upwards from the working bottom plate, a third mounting frame connected with the upper end of the third support through a sixth driving device, a plurality of vertical nitrogen blowing pipes arranged at the bottom of the third mounting frame, and a nitrogen conveying pipe arranged on the third mounting frame and used for providing hot nitrogen for the nitrogen blowing pipes; the control module is electrically connected with the liquid transferring module, the magnetic bar module, the nitrogen blowing module and the charging module; the control module is used for controlling the pipettor to be positioned at any position of the gun head box, the magnetic bead extraction box and the detection test tube and controlling the first driving device to drive the pipettor to move up and down; the control module is used for controlling the magnetic rod sleeve to be positioned at the position of the magnetic bead extraction box, controlling the third driving device to drive the second mounting block to move up and down, controlling the fourth driving device to drive the magnetic rod sleeve to move up and down in a reciprocating manner, and controlling the fifth driving device to drive the magnetic rod to stretch into and out of the magnetic rod sleeve up and down; the control module is used for controlling the nitrogen blowing pipe to be located at the position of the magnetic bead extraction box and controlling the sixth driving device to drive the nitrogen blowing pipe to move up and down.
Further, each pipettor is including setting firmly pipette, the piston assembly pull pole in the pipette on first mounting bracket, and the pull pole upwards runs through first mounting bracket and extends to first diaphragm below, and pull pole surface cover is equipped with the first spring of stretching out and drawing back between first mounting bracket and pull pole upper end tip.
Further, the first mounting frame comprises a first bottom plate extending transversely and a first top plate arranged above the first bottom plate and extending transversely; the lower end of each pipette penetrates through the first bottom plate from top to bottom, and the upper end of each pipette extends to the bottom surface of the first top plate; the upper end of each first spring is connected with a first plug fastened at the upper end part of the pull rod, and the lower end of each first spring is connected with a second plug fixedly arranged at the bottom of the first top plate and adapted to the upper end of the pipette; the upper end of each drawing rod penetrates through the second plug and extends to the lower part of the first transverse plate, and the lower end of each drawing rod penetrates through the second plug and is in piston type sliding fit in the pipette.
The liquid transfer module further comprises a liquid transfer module, the liquid transfer module comprises a liquid transfer module and a liquid transfer module, the liquid transfer module further comprises a liquid transfer module and a liquid transfer module, the liquid transfer module further comprises a liquid transfer module and a liquid transfer module, the liquid transfer module further comprises a liquid transfer module head baffle, the liquid transfer module head baffle comprises a first baffle transversely extending to the bottom of the first bottom plate and guide columns respectively formed by upwards bending and extending from two ends of the first baffle, and the first baffle is provided with a plurality of limiting sleeves vertically penetrating through the first baffle; each guide post penetrates through the first bottom plate and the first top plate from bottom to top and extends out of the first top plate, a stop block is arranged on the outer surface of each guide post in a protruding mode along the radial direction and located between the first bottom plate and the first top plate, and a second spring is sleeved on the outer surface of each guide post and located between the bottom of each stop block and the first bottom plate; the lower end of each pipette penetrates through the first bottom plate and is matched in the limiting sleeve; the first transverse plate is used for pressing down the upper end of the guide column to push the first baffle plate to be separated from the bottom end of the pipette.
Further, the pipette tip box is used for placing a plurality of vertical pipette tips, and the magnetic bead extraction box is used for accommodating different solutions including extraction magnetic beads and eluent; a cavity with an opening at the bottom end of the pipette is formed between the lower end of the pull rod and the pipette, and the second driving device drives the first transverse plate to press down the pull rod so as to enable the pipette to be provided with a pipette head; the second driving device drives the first transverse plate to press down the drawing rod, and the second driving device reversely drives the first transverse plate to move upwards so that the pipette sucks the solution in the magnetic bead extraction box; when the second driving device drives the first transverse plate to press down the drawing rod, the lower end of the drawing rod presses the solution in the cavity so as to enable the pipette to perform liquid releasing operation.
Further, when the magnetic bar module is positioned above the extraction magnetic beads, the fourth driving device drives the magnetic bar sleeve to reciprocate up and down, the lower end of the magnetic bar sleeve is used for stirring the extraction magnetic beads, the fifth driving device drives the magnetic bars to fall into the magnetic bar sleeve from top to bottom and extend to the lower part of the magnetic bar sleeve, the lower end of the magnetic bars is used for performing magnetic attraction operation on the magnetic beads in the magnetic bead extraction box, and the bottom end of the magnetic bar sleeve is used for preventing the magnetic beads from entering the magnetic bar sleeve; when the magnetic rod module is positioned above the eluent, the third driving device drives the magnetic rod and the magnetic rod sleeve to enter the eluent from top to bottom, the fifth driving device drives the magnetic rod to be pulled out of the magnetic rod sleeve from bottom to top so that the magnetic attraction of the magnetic beads on the lower end of the magnetic rod sleeve is released, and the magnetic beads and the target objects attached to the surfaces of the magnetic beads enter the eluent, and the fourth driving device drives the magnetic rod sleeve to reciprocate from top to bottom so that the target objects attached to the surfaces of the magnetic beads are eluted into the eluent.
Further, when the nitrogen blowing module is located above the eluent in the magnetic bead extraction box, the control module is used for controlling the sixth driving device to drive the nitrogen blowing pipe to descend into the eluent so as to perform nitrogen blowing concentration operation on the eluent mixed with the target object.
Furthermore, the mixture of the eluent after the nitrogen blowing treatment and the target object is used as a sample to be tested, the test tube is used for accommodating a test strip, the control module is also used for controlling the liquid transfer device to absorb the sample to be tested at the position of the eluent and release the sample to the test solution after the nitrogen blowing module treatment, so that the sample to be tested reacts with the test strip, and the food safety detection analysis equipment further comprises a camera for acquiring an image after the reaction so as to analyze an experimental result.
Further, the method also comprises the following steps: the first driving rod, the second driving rod, the third driving rod, the first guide rod and the second guide rod are respectively and transversely arranged on the working bottom plate in an extending mode; the first driving rod penetrates through the lower end of the first support in front and at the back, and the lower end of the first support is arranged on the first driving rod and the first guide rod in a sliding manner; the lower end of the second bracket is slidably arranged on the second driving rod and the second guide rod; the third driving rod penetrates through the lower end of the third support in front and back, and the lower end of the third support is arranged on the third driving rod, the first guide rod and the second guide rod in a sliding mode.
Furthermore, the first baffle, the guide post, the limiting sleeve and the stop block are connected in an integrated manner; the first bottom plate is fixedly connected with the first top plate; the pipette is respectively fixedly connected with the first bottom plate and the first top plate; the top of the magnetic rod sleeve is fixedly connected with the bottom of the second mounting frame, and the top of the magnetic rod is fixedly connected with the bottom of the second transverse plate; the nitrogen blowing pipe is fixedly connected with the bottom of the third mounting rack; the nitrogen feeding pipe is fixedly connected with the top of the third mounting frame.
Has the advantages that: the invention relates to food safety detection and analysis equipment, which controls a liquid transfer device to clamp a liquid transfer gun head, suck a solution or release the solution by positioning the liquid transfer device at any position of a gun head box, a magnetic bead extraction box and a detection test tube; the pipettor is positioned above the magnetic bead extraction box, so that the magnetic rod sleeve moves up and down in a reciprocating manner to perform up and down oscillation operation, and the magnetic rod stretches into and out of the magnetic rod sleeve up and down to perform magnetic attraction or release magnetic attraction; performing nitrogen blowing operation when the nitrogen blowing pipe is positioned at the position of the magnetic bead extraction box; therefore, the device can automatically control the biological operations such as magnetic bead extraction and separation, sample transfer, solution detection and the like, solve the problem of complex procedures when the existing food safety detection and analysis equipment carries out the biological operations such as magnetic bead extraction and separation, sample transfer, solution detection and the like, meet the requirement of carrying out high-flux extraction and purification on a sample, greatly reduce the sample pollution in the experimental operation process, liberate researchers from an experiment table and greatly improve the repeatability of experimental results.
Drawings
FIG. 1 is a schematic perspective view of a food safety inspection and analysis device according to the present invention;
FIG. 2a is a front view of the food safety inspection analysis device of FIG. 1;
FIG. 2b is a top view of the food safety inspection analysis device of FIG. 1;
FIG. 3 is a schematic structural diagram of a loading module of the food safety inspection and analysis device;
FIG. 4 is a schematic diagram of a pipetting module of the food safety inspection and analysis apparatus;
FIG. 5 is a front view of the pipetting module of FIG. 4;
fig. 6 is a schematic structural diagram of a pipette;
FIG. 7 is a schematic view of the assembly of the tip ejection baffle of the pipetting module of FIG. 5;
FIG. 8 is a schematic structural view of the cover for the lance head of FIG. 7;
FIG. 9 is a schematic structural diagram of a magnetic rod module of the food safety detection and analysis device;
FIG. 10 is a front view of the magnetic rod module of FIG. 9;
FIG. 11 is a schematic structural diagram of a nitrogen blowing module of the food safety detection and analysis device;
FIG. 12 is a schematic structural diagram of a mobile module of the food safety detection and analysis device;
FIG. 13 is a schematic view of the operation process of magnetic bead stirring, magnetic bead suction, magnetic bead release and elution.
Detailed Description
The technical scheme provided by the invention is explained in detail in the following with the accompanying drawings.
As shown in fig. 1 to 13, in the present embodiment, the food safety detection and analysis device has a work base plate 1, including: the device comprises a loading module 10, a pipetting module 20, a magnetic bar module 30, a nitrogen blowing module 40 and a control module 60.
On work bottom plate 1 was located to the module of feeding 10, including from fixed setting up a rifle head box 11, a waste material box 14, a magnetic bead on work bottom plate 1 forward backward and draw box 12 and a detection test tube 13, rifle head box 11 is used for vertically placing a plurality of liquid-transfering gun heads 111, and magnetic bead draws box 12 and is used for acceping different solutions respectively and includes sample solution, extraction magnetic bead, neutralization solution, extract, washing liquid, eluant, and detection test tube 13 is used for acceping the detection test paper strip.
The pipetting module 20 comprises a first bracket 21, a first mounting frame 22, a first driving device 23, a first transverse plate 24, a second driving device 25, a plurality of pipettes 26 which are transversely arranged on the first mounting frame 22 and vertically extend, and a pipette tip removing baffle 27, wherein the first bracket 21, the first mounting frame 22, the first driving device 23, the first transverse plate 24 and the second driving device are longitudinally extended; first mounting bracket 22 is located between first support 21 upper end and the work bottom plate 1, and first diaphragm 24 transversely extends between first support 21 and first mounting bracket 22, and first drive arrangement 23 sets up and is used for driving first mounting bracket 22 and reciprocates relatively work bottom plate 1 between first support 21 and first mounting bracket 22, and second drive arrangement 25 sets up and is used for driving first diaphragm 24 and reciprocates relatively first mounting bracket 22 between first mounting bracket 22 and first diaphragm 24.
The first driving device 23 comprises a first motor 231 fixedly mounted at the upper end of the first bracket 21, and a first lead screw 232 connected with an output shaft of the first motor 231, wherein the lower end of the first lead screw 233 is connected with the top of the first mounting frame 22; the second driving device 25 comprises a second motor 251 installed on the first mounting frame 22 and a second lead screw 252 connected with an output shaft of the second motor 251, and the lower end of the second lead screw 252 is connected with the first transverse plate 24; moreover, the first mounting frame 22 includes a first bottom plate 221 extending in the transverse direction, and a first top plate 222 located above the first bottom plate 221 and extending in the transverse direction, the first bottom plate 221 is provided with a first through hole 2210 penetrating through the first bottom plate 221 in the vertical direction, the first top plate 222 is provided with a second through hole 2220 penetrating through the first top plate 222 in the vertical direction and corresponding to the first through hole 2210 in a one-to-one manner, and the first bottom plate 221 and the first top plate 222 are fixed relatively.
Each pipettor 26 comprises a pipette 261, a drawing rod 262 adapted in the pipette 261, a first spring 263 arranged outside the drawing rod 262, a first plug 264 connected to the upper end of each first spring 263 and fastened to the upper end of each drawing rod 262 and located above the first top plate 222, and a second plug 265 connected to the lower end of each first spring 263 and fixed to the bottom of the first top plate 222 and through which the drawing rod 262 passes, wherein the first spring 263 is limited between the first plug 264 and the second plug 265 along the outer wall of the pipette 262; the bottom end of each pipette 261 extends through the first through hole 2210 of the first bottom plate 221, and the top end of each pipette 261 extends to the bottom surface of the first top plate 222 and is correspondingly connected to a second plug 265; the lower end of each pulling rod 262 extends through the second plug 265 and fits into the pipette 261, a cavity 266 with an opening at the bottom end of the pipette 261 is formed between the lower end of the pulling rod 262 and the pipette 261, and the upper end of each pulling rod 262 extends through the second through hole 2220 of the first top plate 222 and extends to a position below the first horizontal plate 24.
The cover 27 comprises a first cover 271 extending transversely, and guide posts 272 formed by bending and extending upwards from two ends of the first cover 271; a plurality of position-limiting sleeves 2710 are arranged on the first baffle 271, and each position-limiting sleeve 2710 is provided with a third through hole 2711 which vertically penetrates through the first baffle 271.
The first baffle 271 of the decapping head baffle 27 is arranged at the bottom of the first base plate 221 of the first installation rack 22 in parallel, the third through holes 2711 of the first baffle 271 and the first through holes 2210 of the first base plate 221 are arranged in one-to-one correspondence, that is, the third through holes 2711 are opposite to the pipettes 261; moreover, the guiding column 272 penetrates through the first bottom plate 221 and the first top plate 222 from bottom to top and extends to the upper side of the first top plate 222, a stop 274 is radially and convexly arranged on the outer peripheral surface of the guiding column 272, a second spring 275 is sleeved on the outer side surface of the guiding column 272, and the second spring 275 is located between the bottom of the stop 274 and the first bottom plate 221.
The first baffle 271, the two guide posts 272, the limiting sleeve 2710 and the stop 274 are connected integrally; the guide posts 272 are light posts; the second spring 275 extends and retracts between the stopper 274 and the first bottom plate 221 along the guide post 272; the first stopper 274 is located between the first top plate 222 and the first spring 275; the upper end of the guiding column 272 is movably fitted on the first top plate 222 all the time.
When the bottom end of each pipette 261 extends through the first through hole 2210 and then fits into the third through hole 2711 of the corresponding position-limiting sleeve 2710, the bottom end of each pipette 261 is used for installing the pipette tip 111, and each position-limiting sleeve 2710 is embedded between one pipette tip 111 and one pipette 261. When the first horizontal plate 24 is pressed down to the upper end of the guide column 272 of the pipette tip removing baffle 27, the first baffle 271 is pushed to remove the pipette tip 111 from the pipette 261, so as to achieve the purpose of automatic discharging.
The food safety detection and analysis equipment further comprises a first driving rod 2, a second driving rod 3, a third driving rod 4, a first guide rod 5 and a second guide rod 6 which are transversely extended and arranged on the top surface of the working bottom plate 1 respectively, and a seventh motor 100, an eighth motor 200 and a ninth motor 300 which are arranged on the working bottom plate 1 respectively; the seventh motor 100 is used for driving the first driving rod 2 to rotate, the eighth motor 200 is used for driving the second driving rod 3 to rotate, and the ninth motor 300 is used for driving the third driving rod 4 to rotate. First support 21 lower extreme is slided and is located first actuating lever 2, a guide bar 5 on, specifically for first support 21 lower extreme is equipped with the screw hole that runs through first support 21 around, and first actuating lever 2 runs through screw hole and the 2 front ends of first actuating lever and connects seventh motor 100 output shafts.
The control module 60 is electrically connected to the pipetting module 20, and the control module 60 is configured to control the seventh motor 100 to drive the first support 21 to move back and forth along the first driving rod 2, so that the pipettor 26 of the pipetting module 20 moves between the tip box 11, the magnetic bead extraction box 12, the detection test tube 13, and the waste box 14.
When liquid transfer operation needs to be performed on a sample solution, the control module 60 is configured to control the seventh motor 100 to drive the first bracket 21 to move along the first driving rod 2 until the pipettor 26 moves to a position above the leftmost pipette head 111 placed in the pipette head box 11, the control module 60 controls the first motor 231 to start to drive the first mounting frame 22 to drive the pipette 261 of the pipettor 26 to descend, then starts the second motor 251 to drive the first horizontal plate 24 to press down the drawing rod 262 so as to mount the pipette head 111 at the lower end of the pipette 261, the pipettor 26 is configured to clamp the pipette head 111 and form a liquid suction pipeline with the pipette head 111, and then reversely operate the first motor 231 to drive the first mounting frame 22 to drive the pipette 261 to move up;
the control module 60 controls the seventh motor 100 to drive the first bracket 21 to drive the pipetter 26 to move along the first driving rod 2 until the pipetter 26 is located at a position above the sample solution in the magnetic bead extraction box 12, starts the first motor 231 to drive the pipette 261 of the pipetter 26 to move downward relative to the sample solution by the first mounting bracket 22, controls the second motor 251 to drive the first horizontal plate 24 to press down the pull rod 262 of the pipetter 26, the pull rod 262 moves downward relative to the pipette 261, the air pressure in the cavity 266 formed between the lower end of the pull rod 262 and the pipette 261 increases, drives the first horizontal plate 24 to move upward by the reverse rotation of the second motor 251, reduces the air pressure in the cavity 266 to enable the pipette to complete the suction of the sample solution, the sample solution is kept in the liquid suction pipeline, and after liquid suction is finished, the first motor 231 is operated reversely, so that the first mounting frame 22 drives the pipette 261 to move upwards; the control module 60 controls the seventh motor 100 to drive the first support 21 to drive the pipettor 26 and the pipetting gun head 111 clamped by the pipettor 26 to move to the position above the extracted magnetic beads in the magnetic bead extraction box 12 along the first driving rod 2, and then controls the second motor 251 to drive the first horizontal plate 24 to press down the drawing rod 262 of the pipettor 26, wherein the drawing rod 262 moves downwards relative to the pipettor 261, the lower end of the drawing rod 262 squeezes the sample solution in the cavity 266, so that the pipettor 26 injects the sample solution into the extracted magnetic beads in the magnetic bead extraction box 12 to complete the pipetting work of the sample solution.
When the first horizontal plate 24 is pressed down to the upper end of the guide column 272 of the pipette tip removing baffle 27, the first horizontal plate 24 pushes the first baffle 271 of the pipette tip removing baffle 27 to remove the pipette tip 111 from the pipette 261 and place the pipette tip 111 in the waste material box 14, so as to achieve the purpose of automatic discharging.
The magnetic rod module 30 comprises a second support 31 extending upwards from the work bottom plate 1, a second mounting block 32 connected to the upper end of the second support 31 through a third driving device 33, a second mounting frame 38 connected to the second mounting block 32 through a fifth driving device 39, a second transverse plate 34 connected to the second mounting block 32 through a fourth driving device 35 and located above the second mounting frame 38, a plurality of vertical magnetic rod sleeves 36 arranged at the bottom of the second mounting frame 38, and a plurality of vertical magnetic rods 37 arranged at the bottom of the second transverse plate 34.
The third driving device 33 comprises a third motor 331 mounted on the second bracket 31, and a third screw 332 connected with an output shaft of the third motor 331, wherein the lower end of the third screw 332 is connected with the top of the second mounting block 32; the fifth driving device 39 comprises a fifth motor 391 mounted on the second mounting block 32, and a fifth lead screw 392 connected with an output shaft of the fifth motor 391, wherein the lower end of the fifth lead screw 392 is connected with the top of the second mounting frame 38; a first mounting part 381 extending transversely is arranged at the top of the second mounting frame 38, the top surface of the second mounting part 381 is connected to the lower end of the fifth screw 392, a second mounting part 382 extending transversely is arranged at the bottom of the second mounting frame 38, a plurality of magnetic rod sleeves 36 extending longitudinally are arranged at the bottom surface of the second mounting part 382, and each magnetic rod sleeve 36 is of a sleeve structure penetrating from top to bottom; the fourth driving device 35 includes a fourth motor 351 installed on the second mounting block 32, and a fourth lead screw 352 connected to an output shaft of the fourth motor 351, a second horizontal plate 34 extending transversely is disposed between the first mounting portion 381 and the second mounting block 322 of the second mounting frame 38, a lower end of the fourth lead screw 352 penetrates the first mounting portion 381 from top to bottom, is connected to a top surface of the second horizontal plate 34, penetrates the second horizontal plate 34 from top to bottom, and extends to a position above the second mounting portion 382, and a plurality of magnetic rods 37 extending longitudinally are arranged on a bottom surface of the second horizontal plate 34.
The lower end of the second bracket 31 is slidably arranged on the second driving rod 3 and the second guide rod 6; the lower end of the second bracket 31 is provided with a threaded hole which penetrates through the second bracket 31 from front to back, and the second driving rod 3 penetrates through the threaded hole and the front end of the second driving rod 3 and is connected with the output shaft of the eighth motor 200.
The control module 60 is electrically connected to the magnetic rod module 30, and the control module 60 is configured to control the eighth motor 200 to drive the second support 31 to move back and forth along the second driving rod 3, so that the magnetic rod sleeve 36 of the magnetic rod module 30 moves between different solution positions in the magnetic bead extraction cartridge 12.
When the magnetic rod module 30 is required to perform magnetic bead extraction, separation and elution operations on different solutions in the magnetic bead extraction cartridge 12, the control module 60 is configured to control the eighth motor 200 to drive the second driving rod 3 to rotate so as to move the magnetic rod sleeve 36 to a position above an extracted magnetic bead of the magnetic bead extraction cartridge 12, and is configured to control the third motor 331 to drive the second mounting block 32 to drive the magnetic rod sleeve 36 to move downward relative to the extracted magnetic bead; the control module 60 is configured to control the fifth motor 391 to reciprocate and rotate forward and backward to drive the second mounting portion 382 to drive the magnetic rod sleeve 36 to perform a short-process up-and-down reciprocating motion in the extracted magnetic beads, so as to stir the extracted magnetic beads, where target objects are adsorbed on the surfaces of the magnetic beads; the control module 60 is configured to control the fourth motor 351 to drive the second transverse plate 34 to drive the magnetic rod 37 to move downward relative to the magnetic rod sleeve 36, the magnetic rod 37 penetrates through the magnetic rod sleeve 36 from top to bottom and extends out of the lower portion of the bottom end of the magnetic rod sleeve 36, the lower end of the magnetic rod sleeve 36 blocks magnetic beads from entering the magnetic rod sleeve 36, and the magnetic rod 37 enters the extracted magnetic beads to adsorb the magnetic beads by magnetic force; after the magnetic attraction operation is completed, the control module 60 is configured to control the eighth motor 200 to drive the second driving rod 3 to drive the magnetic rod sleeve 36 to move to a position above the eluent in the magnetic bead extraction box 12, and to control the third motor 331 to drive the second mounting block 32 to drive the magnetic rod sleeve 36 to move downward relative to the eluent, after the magnetic rod 37 and the magnetic rod sleeve 36 enter the eluent from top to bottom, the control module 60 further controls the fourth motor 351 to drive the second transverse plate 34 to drive the magnetic rod 37 to be extracted from the magnetic rod sleeve 36 from bottom to top, during this period, the magnetic rod 37 drives the adsorbed magnetic beads to move upward, until the magnetic rod 37 contracts into the magnetic rod sleeve 36, the magnetic beads are blocked by the bottom end of the magnetic rod sleeve 36 and separated from the magnetic rod 37, so as to lose magnetism and then fall down, so as to release the magnetic beads and the target objects adsorbed on the surfaces of the magnetic beads into the eluent, and the control module 60 further controls the fifth motor 391 to reciprocate and rotate forward and backward, so as to drive the second mounting portion 382 to drive the magnetic rod sleeve 36 to reciprocate in the eluent up and down in order to adsorb the magnetic beads and reciprocate in the magnetic beads and down in the eluent, so as to adsorb the magnetic rod sleeve 36 Mixing the target with the eluent, thereby eluting the target into the eluent; after the elution is completed, the control module 60 is configured to control the fourth motor 351 to drive the magnetic rod 37 to descend so as to absorb the magnetic beads in the eluent again, so that the magnetic beads used as waste at this time are removed out of the eluent, and the eluent containing the target object and no magnetic beads can be obtained, thereby completing the magnetic bead extraction and separation process.
The nitrogen blowing module 40 comprises a third support 41 extending longitudinally, a third mounting rack 42, a sixth driving device 43 arranged on the third support 41 and used for driving the third mounting rack 42 to move up and down, a plurality of vertically extending nitrogen blowing pipes 44 arranged at the bottom of the third mounting rack 42, and a nitrogen feeding pipe 45 arranged on the third mounting rack 42 and used for providing hot nitrogen for the nitrogen blowing pipes 44, wherein the lower end of the nitrogen feeding pipe 45 extends downwards from the upper surface of the third mounting rack 42 to be communicated with each nitrogen blowing pipe 44, and the upper end of the nitrogen feeding pipe 45 extends upwards from the upper surface of the third mounting rack 42 and is connected with an external compressor used for providing hot nitrogen.
The sixth driving device 43 includes a sixth motor 431 mounted on the third bracket 41, and a sixth lead screw 432 connected to an output shaft of the sixth motor 431, a threaded hole penetrating the third mounting bracket 42 up and down is formed in the third mounting bracket 42, a lower end of the sixth lead screw 432 penetrates the third mounting bracket 42 from top to bottom, and an outer peripheral surface of a lower end of the sixth lead screw 432 is in threaded fit with the threaded hole of the third mounting bracket 42. The sixth motor 431 is fixedly connected with the third bracket 41, the lower end of an output shaft of the sixth motor 431 is fixedly connected with the upper end of a sixth lead screw 432, and the nitrogen blowing pipe 44 and the nitrogen feeding pipe 45 are fixedly connected with the third mounting frame 42. The lower end of the third bracket 41 is slidably fitted on the third driving rod 4, the first guide rod 5 and the second guide rod 6. The lower end of the third bracket 41 is provided with threaded holes which penetrate through the third bracket 41 in the front and back directions, and the third driving rod 4 penetrates through the threaded holes and the rear end of the third driving rod 4 is connected with the output shaft of the ninth motor 300.
The nitrogen blowing module 40 is electrically connected to the control module 60, and the control module 60 is configured to control the ninth motor 300 to drive the third driving rod 4 to drive the third bracket 41 to move back and forth along the first guide rod 5 and the second guide rod 6, so that the nitrogen blowing pipe 44 of the nitrogen blowing module 40 moves to the eluent position.
When the nitrogen blowing concentration treatment of the mixture of the target object and the eluent needs to be performed, the control module 60 is configured to control the ninth motor 300 to enable the third bracket 41 to move along the third driving rod 4 until the nitrogen blowing tube 44 moves to the position above the eluent placed in the magnetic bead extraction box 12, control the sixth motor 431 to drive the third mounting frame 42 to drive the nitrogen blowing tube 44 to descend relative to the eluent, so that the lower end of the nitrogen blowing tube 44 descends into the eluent, start the external compressor and introduce hot nitrogen gas into the nitrogen blowing tube 44 through the nitrogen feeding tube 45, enable the nitrogen blowing tube 44 to perform the nitrogen blowing operation on the mixture of the eluent and the target object contained in the eluent, complete the nitrogen blowing operation when the set time is up, at this time, stop introducing the hot nitrogen gas, and reversely drive the ninth motor 300 to enable the nitrogen blowing tube 44 to ascend to the preset zero position.
Through move liquid module 20, bar magnet module 30 and nitrogen blow module 40 and handle the back, the mixture of target object and eluant is as the sample that awaits measuring, control module 60 is used for blowing module 40 at nitrogen and handles back control pipettor 26 and absorb the sample that awaits measuring of sample eluant position department and release liquid to the detection solution in, so that the sample that awaits measuring carries out abundant reaction with the detection test paper strip in the detection solution, treat that the detection time of setting is then, utilize the camera 70 of locating on the work bottom plate 1 specifically to accomplish the image acquisition work after the reaction for the CCD camera, and the liquid crystal display who connects in the cooperation, reach imaging data and handle, then realize the analysis experiment result of the quantitative determination of the sample that awaits measuring.
The food safety detection analysis equipment provided by the application is characterized in that the pipettor 26 is positioned at any one of the gun head box 11, the magnetic bead extraction box 12 and the detection test tube 13, the pipettor 26 is used for clamping the pipette head 111 when being positioned at the position above the gun head box 11, the pipettor 26 is used for sucking a sample solution when being positioned at the position above the sample solution of the magnetic bead extraction box 12, the magnetic rod sleeve 36 is used for stirring and mixing the magnetic beads and sucking the magnetic beads when being positioned at the position above the extracted magnetic beads of the magnetic bead extraction box 12, the pipettor 26 is used for releasing the magnetic beads and eluting the target objects adsorbed on the surfaces of the magnetic beads into the eluent when being positioned at the position above the eluent of the magnetic bead extraction box 12, the nitrogen blowing pipe 44 is used for blowing nitrogen to a mixture of the eluent and the target objects mixed with the target objects, and the mixture of the target objects and the eluent after the nitrogen blowing treatment are used as a sample to be detected, when the pipettor 26 is positioned above the detection test tube 13, the sample to be detected is sucked and transferred to the detection test strip in the detection solution for detection, so that the problem of complex procedures when the existing food safety detection and analysis equipment performs biological operations such as magnetic bead extraction and separation, sample transfer, solution detection and the like can be solved, the requirement of high-throughput extraction and purification of the sample is met, the sample pollution in the experimental operation process is greatly reduced, researchers are liberated from an experiment table, and the repeatability of the experimental result is greatly improved.
Claims (10)
1. A food safety inspection analytical equipment, has a work bottom plate (1), characterized by, includes:
the loading module (10) comprises a gun head box (11), a magnetic bead extraction box (12) and a detection test tube (13) which are arranged on the working bottom plate (1);
the liquid transfer module (20) comprises a first support (21) extending upwards from the working bottom plate, a first mounting frame (22) connected with the upper end of the first support through a first driving device (23), a first transverse plate (24) connected with the first mounting frame through a second driving device (25), and a plurality of vertical pipettors (26) arranged at the bottom of the first mounting frame;
the magnetic rod module (30) comprises a second support (31) extending upwards from the working bottom plate, a second mounting block (32) connected with the upper end of the second support through a third driving device (33), a second mounting frame (38) connected with the second mounting block through a fifth driving device (39), a second transverse plate (34) connected with the second mounting block through a fourth driving device (35) and positioned above the second mounting frame, a plurality of vertical magnetic rod sleeves (36) arranged at the bottom of the second mounting frame, and a plurality of vertical magnetic rods (37) arranged at the bottom of the second transverse plate;
the nitrogen blowing module (40) comprises a third support (41) extending upwards from the working bottom plate, a third mounting frame (42) connected with the upper end of the third support through a sixth driving device (43), a plurality of vertical nitrogen blowing pipes (44) arranged at the bottom of the third mounting frame, and a nitrogen feeding pipe (45) arranged on the third mounting frame and used for providing hot nitrogen for the nitrogen blowing pipes;
the control module (60) is electrically connected with the liquid transferring module, the magnetic bar module, the nitrogen blowing module and the charging module; the control module is used for controlling the pipettor to be positioned at any position of the gun head box, the magnetic bead extraction box and the detection test tube and controlling the first driving device to drive the pipettor to move up and down; the control module is used for controlling the magnetic rod sleeve to be located at the position of the magnetic bead extraction box, controlling the third driving device to drive the second mounting block to move up and down, controlling the fourth driving device to drive the magnetic rod sleeve to move up and down in a reciprocating mode, and controlling the fifth driving device to drive the magnetic rod to stretch out and draw back in and out of the magnetic rod sleeve up and down; the control module is used for controlling the nitrogen blowing pipe to be located at the position of the magnetic bead extraction box and controlling the sixth driving device to drive the nitrogen blowing pipe to move up and down.
2. The food safety detection and analysis device according to claim 1, wherein each pipette comprises a pipette (261) fixedly arranged on the first mounting frame, and a drawing rod (262) piston-mounted in the pipette, the drawing rod extends upwards through the first mounting frame and extends below the first transverse plate, and a first spring (263) extending between the first mounting frame and the upper end of the drawing rod is sleeved on the outer surface of the drawing rod.
3. The food safety detection and analysis device of claim 2, wherein the first mounting bracket comprises a first bottom plate (221) extending laterally, a first top plate (222) disposed above the first bottom plate and extending laterally; the lower end of each pipette penetrates through the first bottom plate from top to bottom, and the upper end of each pipette extends to the bottom surface of the first top plate; the upper end of each first spring is connected with a first plug (264) fastened at the upper end of the pull rod, and the lower end of each first spring is connected with a second plug (265) fixedly arranged at the bottom of the first top plate and adapted to the upper end of the pipette; the upper end of each drawing rod penetrates through the second plug and extends to the lower part of the first transverse plate, and the lower end of each drawing rod penetrates through the second plug and is in piston type sliding fit in the pipette.
4. The food safety detection and analysis equipment according to claim 3, wherein the pipetting module further comprises a pipette head baffle (27), the pipette head baffle comprises a first baffle (271) transversely extending to the bottom of the first bottom plate and guide columns (272) respectively bent upwards from two ends of the first baffle and formed in an extending manner, and the first baffle is provided with a plurality of limiting sleeves (2710) vertically penetrating through the first baffle; each guide post penetrates through the first bottom plate and the first top plate from bottom to top and extends to the outside of the first top plate, a stop block (274) is arranged on the outer surface of each guide post in a protruding mode along the radial direction and located between the first bottom plate and the first top plate, and a second spring (275) is sleeved on the outer surface of each guide post and located between the bottom of each stop block and the first bottom plate; the lower end of each pipette penetrates through the first bottom plate and is matched in the limiting sleeve; the first transverse plate is used for pressing down the upper end of the guide column to push the first baffle plate to be separated from the bottom end of the pipette.
5. The food safety detection and analysis equipment according to claim 4, wherein the tip box is used for placing a plurality of vertical pipette tips (111), and the magnetic bead extraction box is used for accommodating different solutions including extraction magnetic beads and eluent; a cavity (266) with an opening at the bottom end of the pipette is formed between the lower end of the pull rod and the pipette, and the second driving device drives the first transverse plate to press down the pull rod so as to enable the pipette to be provided with a pipette head; the second driving device drives the first transverse plate to press down the drawing rod, and the second driving device reverses the first transverse plate to move upwards so that the pipette sucks the solution in the magnetic bead extraction box; when the second driving device drives the first transverse plate to press down the drawing rod, the lower end of the drawing rod presses the solution in the cavity so as to enable the pipette to perform liquid releasing operation.
6. The food safety detection and analysis device according to claim 5, wherein when the magnetic rod module is located above the extracted magnetic beads, the fourth driving device drives the magnetic rod sleeve to reciprocate up and down, the lower end of the magnetic rod sleeve is used for stirring the extracted magnetic beads, the fifth driving device drives the magnetic rod to fall into the magnetic rod sleeve from top to bottom and extend to the lower part of the magnetic rod sleeve, the lower end of the magnetic rod is used for magnetically attracting the magnetic beads in the magnetic bead extraction box, and the bottom end of the magnetic rod sleeve is used for preventing the magnetic beads from entering the magnetic rod sleeve; when the magnetic rod module is positioned above the eluent, the third driving device drives the magnetic rod and the magnetic rod sleeve to enter the eluent from top to bottom, the fifth driving device drives the magnetic rod to be pulled out of the magnetic rod sleeve from bottom to top so that the magnetic attraction of the magnetic beads on the lower end of the magnetic rod sleeve is released, and the magnetic beads and the target objects attached to the surfaces of the magnetic beads enter the eluent, and the fourth driving device drives the magnetic rod sleeve to reciprocate from top to bottom so that the target objects attached to the surfaces of the magnetic beads are eluted into the eluent.
7. The food safety detection and analysis device according to claim 6, wherein when the nitrogen blowing module is located at a position above the eluent in the magnetic bead extraction box, the control module is configured to control the sixth driving device to drive the nitrogen blowing pipe to descend into the eluent so as to perform nitrogen blowing concentration operation on the eluent mixed with the target.
8. The food safety detection and analysis device according to claim 7, wherein the mixture of the eluate after the nitrogen blowing process and the target is used as a sample to be tested, the test tube is used for accommodating a test strip, the control module is further used for controlling the liquid shifter to suck the sample to be tested at the position of the eluate and release the sample to be tested into the test solution after the nitrogen blowing module process, so that the sample to be tested and the test strip react, and the food safety detection and analysis device further comprises a camera (70) for acquiring an image after the reaction to analyze an experimental result.
9. The food safety detection and analysis device of claim 1, further comprising: a first driving rod (2), a second driving rod (3), a third driving rod (4), a first guide rod (5) and a second guide rod (6) which are respectively arranged on the working bottom plate in a transversely extending manner; the first driving rod penetrates through the lower end of the first support in front and at the back, and the lower end of the first support is arranged on the first driving rod and the first guide rod in a sliding manner; the lower end of the second bracket is slidably arranged on the second driving rod and the second guide rod; the third driving rod penetrates through the lower end of the third support in the front and at the back, and the lower end of the third support is slidably arranged on the third driving rod, the first guide rod and the second guide rod.
10. The food safety detection and analysis device according to claim 4, wherein the first baffle, the guide column, the limiting sleeve and the stop block are integrally connected; the first bottom plate is fixedly connected with the first top plate; the pipette is respectively fixedly connected with the first bottom plate and the first top plate; the top of the magnetic rod sleeve is fixedly connected with the bottom of the second mounting frame, and the top of the magnetic rod is fixedly connected with the bottom of the second transverse plate; the nitrogen blowing pipe is fixedly connected with the bottom of the third mounting rack; the nitrogen feeding pipe is fixedly connected with the top of the third mounting frame.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210316965.6A CN114675045A (en) | 2022-03-29 | 2022-03-29 | Food safety detection analytical equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210316965.6A CN114675045A (en) | 2022-03-29 | 2022-03-29 | Food safety detection analytical equipment |
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| Publication Number | Publication Date |
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| CN114675045A true CN114675045A (en) | 2022-06-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210316965.6A Pending CN114675045A (en) | 2022-03-29 | 2022-03-29 | Food safety detection analytical equipment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116859070A (en) * | 2023-09-01 | 2023-10-10 | 广东南国药业有限公司 | Sampling detection device and detection method for medicine production |
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- 2022-03-29 CN CN202210316965.6A patent/CN114675045A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116859070A (en) * | 2023-09-01 | 2023-10-10 | 广东南国药业有限公司 | Sampling detection device and detection method for medicine production |
| CN116859070B (en) * | 2023-09-01 | 2023-11-07 | 广东南国药业有限公司 | Sampling detection device and detection method for medicine production |
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